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Vitiligo

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https://www.readbyqxmd.com/read/29344020/a-case-of-immune-thrombocytopenia-as-a-rare-side-effect-of-an-immunotherapy-with-pd1-blocking-agents-for-metastatic-melanoma
#1
Claudia Pföhler, Hermann Eichler, Barbara Burgard, Nathalie Krecké, Cornelia S L Müller, Thomas Vogt
Background: Checkpoint blocking agents such as pembrolizumab or nivolumab may induce a diversity of mostly autoimmune-mediated side effects. These autoimmune phenomena mainly affect ductless glands such as the pituitary gland (hypophysitis), the thyroid gland (thyreoiditis), the skin (vitiligo and rash), the colon (colitis), and the lung (pneumonitis). Furthermore, many other organs or organ systems may be affected. Case Report: This work describes a case of an immune thrombocytopenia that developed or rather became clinically significant shortly after initiation of a systemic therapy with first nivolumab and later pembrolizumab given due to metastatic melanoma...
November 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29341310/critical-appraisal-of-the-oxidative-stress-pathway-in-vitiligo-a-systematic-review-and-meta-analysis
#2
REVIEW
R Speeckaert, J Dugardin, J Lambert, H Lapeere, E Verhaeghe, M M Speeckaert, N van Geel
BACKGROUND: The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of oxidative stress pathway in vitiligo is a popular although controversial research topic. OBJECTIVE: To clarify the role of the oxidative stress pathway in vitiligo compared to other inflammatory skin disorders and to assess the therapeutic role of antioxidants. METHODS: We conducted a systematic search of the existing literature on the aberrancies of the oxidative stress pathway in vitiligo...
January 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29331748/safety-and-efficacy-of-anti-programmed-death-1-antibodies-in-patients-with-cancer-and-pre-existing-autoimmune-or-inflammatory-disease
#3
François-Xavier Danlos, Anne-Laure Voisin, Valérie Dyevre, Jean-Marie Michot, Emilie Routier, Laurent Taillade, Stéphane Champiat, Sandrine Aspeslagh, Julien Haroche, Laurence Albiges, Christophe Massard, Nicolas Girard, Stéphane Dalle, Benjamin Besse, Salim Laghouati, Jean-Charles Soria, Christine Mateus, Caroline Robert, Emilie Lanoy, Aurélien Marabelle, Olivier Lambotte
OBJECTIVE: Patients with autoimmune or inflammatory disease (AID) are susceptible to immune-related adverse events (irAEs) when treated with immune check-point inhibitors (ICIs). We decided to analyse the safety and effectiveness of anti-PD-1 antibodies in AID patients and look for an association between the presence of pre-existing AID and the clinical outcome. METHODS: In a prospective study of the REISAMIC registry of grade ≥2 irAEs occurring in ICI-treated patients, we studied the associations between pre-existing AID on one hand and irAE-free survival, overall survival and best objective response rate on the other...
January 10, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29330174/views-and-experiences-of-seeking-information-and-help-for-vitiligo-a-qualitative-study-of-written-accounts
#4
Emma Teasdale, Ingrid Muller, Amirah Abdullah Sani, Kim S Thomas, Beth Stuart, Miriam Santer
OBJECTIVES: Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access information and help for vitiligo may influence how they manage such impact. We aimed to explore people's views and experiences of seeking health information and help for vitiligo. DESIGN: Qualitative analysis of free-text responses to four open-ended questions in an online survey...
January 11, 2018: BMJ Open
https://www.readbyqxmd.com/read/29328033/-elemental-status-of-patients-with-various-forms-of-vitiligo
#5
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, I Charischarishvili
Vitiligo is a multifactorial disease in which, in each specific case of its manifestation, different mechanisms of its pathogenesis and different levels of melanin formation in the skin can be involved. Skin is one of the most metabolically active organs. Carrying out a number of vital functions (barrier, protective, respiratory, excretory, metabolic, immune, etc.), it needs microelementss. Of the 92 naturally occurring chemical elements, 81 are found in the human body. Lack of the vital elements, leads to the emergence of diseases, which are based on deficiency, excess or imbalance of micro- and macroelements in the body...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29322633/preclinical-evaluation-of-melanocyte-transplantation-by-chitosan-based-melanocyte-spheroid-patch-to-skin-prepared-by-controlled-sunburn-blistering
#6
Sabrina Mai-Yi Fan, Po-Hua Chen, Yu-Ting Tseng, Jin-Bon Hong, Wannhsin Chen, Tsen-Fang Tsai, Sung-Jan Lin
Transplantation of autologous cultured melanocytes as cell suspension has been used for the treatment of vitiligo. The recipient site is often prepared by laser-mediated dermabrasion. Such procedures encounter disadvantages including prolonged transplantation duration, unsecured cell adherence to lesional skin and potential scarring. To improve this, here we propose a method by preparing recipient sites before transplantation by psoralen and ultraviolet A (PUVA)-induced sunburn followed by transplanting cells with a chitosan-based melanocyte spheroid patch...
January 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29318598/efficacy-and-safety-of-noncultured-melanocyte-keratinocyte-transplant-procedure-for-vitiligo-and-other-leukodermas-a-critical-analysis-of-the-evidence
#7
REVIEW
Paras P Vakharia, Dylan E Lee, Amor Khachemoune
Vitiligo is an acquired pigmentary skin of depigmentation occurring secondary to melanocyte destruction. Vitiligo and other leukodermas have a profound impact on quality of life. Current therapies include medical options, such as phototherapy, topical and systemic corticosteroids, topical calcineurin inhibitors, immunomodulators, and antioxidiants, and surgical options. Surgical options provide melanocytic cells to previously depigmented areas and use either tissue grafting or cellular grafting methods. Topical treatments are often insufficient, and many of the current surgical procedures have shown variable response rates...
January 10, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29318595/the-early-repigmentation-pattern-of-vitiligo-is-related-to-the-source-of-melanocytes-and-by-the-choice-of-therapy-a-retrospective-cohort-study
#8
Ke Yang, Xixi Xiong, Gorkhali Pallavi, Yuting Ling, Fei Ding, Weiwei Duan, Weiling Sun, Gaozhong Ding, Qingli Gong, Wenyuan Zhu, Yan Lu
BACKGROUND: Patients with vitiligo present with different repigmentation patterns in the early recovery stage. OBJECTIVES: To analyze the relationships between early repigmentation patterns in vitiliginous patches, their clinical characteristics, and therapeutic choices. METHODS: Patients with vitiligo seen in the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University from 2010 to 2015, were included, and their clinical records, especially photographs and medical treatments, were reviewed...
January 10, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29315592/identification-of-a-pyranocoumarin-photosensitizer-that-is-a-potent-inhibitor-of-keratinocyte-growth
#9
Jeffrey D Laskin, Yi-Hua Jan, Michele M Jetter, Christophe D Guillon, Thomas M Mariano, Diane E Heck, Ned D Heindel
Photosensitizers are used in the treatment of epidermal proliferation and differentiation disorders such as psoriasis and vitiligo. In the present studies, a ring-expanded carbon homologue of the linear psoralen (furo[3,2-g]benzopyran-7-one) class of photosensitizers, 4,10-dimethyl-2H,8H-benzo[1,2-b:5,4-b']dipyran-2-one (NDH2476), was synthesized and analyzed for biological activity. Following activation by ultraviolet light (UVA, 320-400 nm), NDH2476 was found to be a potent inhibitor of keratinocyte growth (IC50 = 9 nM)...
January 6, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29315555/autoimmunity-and-autoimmune-comorbidities-in-psoriasis
#10
REVIEW
Kazuhisa Furue, Takamichi Ito, Gaku Tsuji, Takafumi Kadono, Takeshi Nakahara, Masutaka Furue
Psoriasis is characterized by widespread scaly erythematous plaques that cause significant physical and psychological burdens for the affected individuals. Accelerated inflammation driven by the TNF-α/IL-23/IL-17 axis is now known to be the major mechanism of the development of psoriasis. In addition, psoriasis has an autoimmune nature that manifests as autoreactive T cells and is comorbid with other autoimmune diseases, such as autoimmune bullous diseases, vitiligo, alopecia and thyroiditis. In this article, we review the recent topics on autoimmunity and autoimmune comorbidities in psoriasis...
January 9, 2018: Immunology
https://www.readbyqxmd.com/read/29314207/vitiligoid-variant-of-lichen-sclerosus-in-young-girls-with-darker-skin-types
#11
Margaret H Dennin, Sarah L Stein, Adena E Rosenblatt
BACKGROUND/OBJECTIVES: Vitiligo and lichen sclerosus are autoimmune disorders characterized by white discoloration, and both frequently affect the anogenital region. Vitiligoid lichen sclerosus refers to a superficial variant of lichen sclerosus in which the lesion appears clinically to be vitiligo based on the predominant presentation of depigmentation and minimal inflammation and sclerosis but histologically is consistent with lichen sclerosus. A limited number of reports have described vitiligoid lichen sclerosus, and from these reports, it appears to primarily affect darker-skinned people...
January 4, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29314180/what-s-new-in-atopic-eczema-an-analysis-of-systematic-reviews-published-in-2015-part-1-epidemiology-and-methodology
#12
REVIEW
E Davies, N K Rogers, A Lloyd-Lavery, D J C Grindlay, K S Thomas
This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 15 systematic reviews that were published during 2015, and focuses on the epidemiology and methodology issues of AE. For systematic reviews on the prevention and treatment of AE, see Part 2 of this update. The worldwide prevalence of AE during childhood has been calculated to be 7.89% (95% CI 7.88-7.89), based on studies of 1 430 329 children from 102 countries...
January 4, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29313915/more-evidence-for-catalase-as-a-pathogenetic-cornerstone-in-vitiligo
#13
M Böhm
No abstract text is available yet for this article.
December 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29312598/interleukin-22-participates-in-the-inflammatory-process-of-vitiligo
#14
Jinjin Dong, Xiaohong An, Hui Zhong, Yichuan Wang, Jing Shang, Jia Zhou
Vitiligo is an acquired depigmentary skin inflammatory disorder. The pathogenesis of inflammatory skin disease involves the release of cytokines from keratinocytes, including interleukin (IL)-1β. IL-22 belongs to a family of cytokines structurally related to IL-10, including IL-19, IL-20, IL-24, and IL-26. In contrast to IL-10, IL-22 has proinflammatory activities. Among skin cell populations only keratinocytes are the major targets of IL-22. In the present study, we demonstrated that IL-22 promoting IL-1β secretion from keratinocytes via the Reactive oxygen species (ROS)-NOD-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1 pathway...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29307645/the-vitiligo-extent-score-ves-and-the-vesplus-are-responsive-instruments-to-assess-global-and-regional-treatment-response-in-patients-with-vitiligo
#15
Nanja van Geel, Marcel Bekkenk, Janny E Lommerts, Khaled Ezzedine, John Harris, Iltefat Hamzavi, Viktoria Eleftheriadou, Mauro Picardo, Alain Taieb, Cecilia Ac Prinsen, Albert Wolkerstorfer, Reinhart Speeckaert
No abstract text is available yet for this article.
January 4, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29300260/dry-eye-assessment-in-patients-with-vitiligo
#16
Sevil Karaman Erdur, Rukiye Aydin, Ali Balevi, Mustafa Ozsutcu, Mehmet Selim Kocabora
PURPOSE: To evaluate tear osmolarity and tear film parameters in patients with vitiligo. METHODS: A total of 25 eyes of 25 patients with vitiligo with periocular involvement (group 1), 30 eyes of 30 patients with vitiligo without periocular involvement (group 2), and 20 eyes of 20 controls (group 3) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film breakup time, scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity...
January 3, 2018: Cornea
https://www.readbyqxmd.com/read/29299628/-vitiligo-and-psoriasis-an-underdiagnosed-coincidence
#17
A-K Dumke, P Elsner, S Goetze
We report the case of a 59-year-old woman who simultaneously suffered from psoriasis and vitiligo. The depigmented areas were predominantly but not exclusively limited to current or former psoriatic plaques. These two diseases share many common features, e. g., both are T‑cell-mediated autoimmune diseases in which the Koebner phenomenon occurs. However, it is still not known whether the coincidence is random or significant. Prospective clinical and epidemiological research will hopefully reveal the association soon...
January 3, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29282672/successful-treatment-of-refractory-vitiligo-with-a-combination-of-khellin-and-308-nm-excimer-lamp-an-open-label-1-year-prospective-study
#18
Samy Fenniche, Anissa Zaouak, Azima Ben Tanfous, Meriem Jrad, Houda Hammami
INTRODUCTION: Phototherapy is the cornerstone of treatment of vitiligo. The 308-nm excimer lamp (EL) induces T cell apoptosis and the stimulation of melanocyte proliferation. Khellin is a furanochromone with a chemical structure close to psoralens. The objective of the study was to evaluate the safety and efficacy of 1-year treatment of recalcitrant vitiligo with a combination of 308-nm EL and khellin. METHODS: Twenty patients with resistant vitiligo were included...
December 27, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29277296/successful-treatment-of-giant-invasive-cutaneous-squamous-cell-carcinoma-by-plum-blossom-needle-assisted-photodynamic-therapy-sequential-with-imiquimod-case-experience
#19
Peiru Wang, Linglin Zhang, Guolong Zhang, Zhongxia Zhou, Haiyan Zhang, Zijun Zhao, Lei Shi Xiuli Wang
Giant cutaneous squamous cell carcinoma (cSCC) in elderly people is difficult to treat. Herein, we report a case of 96-year-old male who was diagnosed to have giant facial invasive SCC (4cm*4.5cm*2 cm). He was successfully treated with plum-blossom needle assisted photodynamic therapy (PDT) sequential with imiquimod. The patient achieved complete remission after 9 sessions of PDT and 3 months of imiquimod but developed residual vitiligo-like hypopigmentation. There was no recurrence at 18 months of follow-up...
December 19, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29249252/-what-s-new-in-dermatological-treatment
#20
M Viguier
On a therapeutic point of view, 2017 in dermatology could be summarized in one disease, one pathway and in one number : atopic dermatitis, JAK inhibitors and 23. 2017 will be the year of the first registration of a biologic treatment in atopic dermatitis, dupilumab, with numerous other drugs currently in development. JAK inhibitors show promising results in several difficult-to-treat conditions, such as alopecia areata, vitiligo or atopic dermatitis, but still warrant confirmation in upcoming controlled trials...
December 2017: Annales de Dermatologie et de Vénéréologie
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