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Efrat Fleissig, Mor Pavlovksy, Anat Loewenstein, Dinah Zur, Hadas Newman, Shay Keren, Dafna Goldenberg, Efrat Bar-Ilan, Michaella Goldstein
PURPOSE: To investigate ocular manifestations in patients with vitiligo by multimodal imaging, including optical coherence tomography (OCT), color fundus photography, and fundus autofluorescence (FAF). METHODS: In this prospective, observational clinical study, vitiligo patients underwent ophthalmologic and dermatologic clinical assessment and imaging by spectral-domain OCT, FAF, and color fundus imaging. Ocular echography was performed as indicated. Statistical analysis was performed using paired T test and Pearson correlation...
March 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Luyan Tang, Wenyu Wu, Wenwen Fu, Yao Hu
Phototherapy is widely used in the treatment of vitiligo. Previous studies have focused on the effects of ultraviolet (UV) radiation on melanocytes; however, the biological effects of phototherapy and melanocytes on keratinocytes remain to be elucidated. To investigate and assess the effects of clinically doses of broad band (BB)-UVA, narrow band (NB)-UVB and melanocytes on human keratinocytes in vitro , clinical doses of BB-UVA or NB-UVB radiation and human melanoma cell A375 co-culture were performed as stress divisors to HaCaT cells...
April 2018: Experimental and Therapeutic Medicine
B Raone, A Patrizi, C Gurioli, A Gazzola, G M Ravaioli
BACKGROUND: Narrowband-ultraviolet B (NB-UVB) is widely used for the treatment of several dermatological diseases. A cutaneous carcinogenic effect has been hypothesized, but not proved. METHODS: We retrospectively reviewed the data of patients treated with NB-UVB between January 1998 and December 2013 at the Dermatology Unit of our University Hospital, to evaluate the cutaneous carcinogenic risk of NB-UVB. RESULTS: 375 patients were included, each receiving a mean follow-up of 6...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
Mary Mina, Lamia Elgarhy, Hanan Al-Saeid, Zeinab Ibrahim
BACKGROUND: Several treatment modalities had been used for the treatment of vitiligo, but the optimal treatment has not yet been identified. OBJECTIVES: To study the efficacy of microneedling with 5-flurouracil vs its efficacy with tacrolimus in the treatment of vitiligo. PATIENTS AND METHODS: Twenty-five patients with vitiligo were subjected to microneedling of 2 patches of vitiligo with dermapen, then application of 5-fluorouracil to 1 patch and tacrolimus on the other patch...
March 12, 2018: Journal of Cosmetic Dermatology
Hassan Ibrahim, Moustafa El Taieb, Zeinab El Gamel, Abdel Rahman El Saied
BACKGROUND: Narrow-band ultraviolet B (NB-UVB) is the gold standard in the treatment of vitiligo. 25-hydroxyvitamin D (25-OH- vitamin D) might play a physiological role in photo-induced melanogenesis in human skin so the association between vitamin D levels and vitiligo still needs to be investigated more thoroughly. OBJECTIVE: we aim to investigate the influence of cumulative doses of NB-UVB phototherapy on vitamin D in patients with vitiligo and their correlation with NB-UVB-induced pigmentation...
March 10, 2018: Journal of Cosmetic Dermatology
Louyse D Correia, Caio C Silva de Castro
No abstract text is available yet for this article.
March 8, 2018: International Journal of Dermatology
Berna Solak, Bahar Sevimli Dikicier, Nur Cihan Cosansu, Teoman Erdem
Introduction: There are a few studies showing an increased risk of insulin resistance, metabolic syndrome, and oxidative stress in patients with vitiligo. Aim: To investigate whether systemic inflammation is increased in vitiligo patients in a case-control study design. Material and methods: Nonsegmental vitiligo patients who had been followed at the outpatient dermatology clinic of a university-affiliated teaching hospital, and healthy controls were enrolled in the study...
October 2017: Postȩpy Dermatologii i Alergologii
W Lu, Y Zhao, Y Kong, W Zhang, W Ma, W Li, K Wang
BACKGROUND: Oxidative stress is one possible pathogenic event in vitiligo that induces melanocyte destruction. Geniposide exerts certain antioxidant effects on various cells by activating the phosphoinositol 3-kinase (PI3K)-Akt signalling pathway. However, researchers have not clearly determined whether geniposide protects human melanocytes from oxidative stress or identified the underlying mechanism of such protection. AIM: To determine whether geniposide protects melanocytes from H2 O2 -induced oxidative damage and to explore the role of the PI3K-Akt signalling pathway in this protective effect...
March 7, 2018: Clinical and Experimental Dermatology
Li Yin, Guangxian Pang, Chao Niu, Maidina Habasi, Jun Dou, Haji Akber Aisa
As an active compound, psoralen is present in various Chinese herbal medicines and has exhibited significant activity in skin disease treatment. Its derivative 8-methoxypsoralan (8-MOP) is the most commonly used drug to induce repigmentation of vitiligo. In our previous screening assays, 4-methyl-6-phenyl-2H-furo[3,2-g]chromen-2-one (MPFC), a psoralen derivative, was identified as more effective tyrosinase and melanin activator than the positive control 8-MOP in consideration of low doses, as well as low toxicity...
March 2, 2018: International Journal of Molecular Medicine
Jung Min Bae, Yu Seok Jung, Han Mi Jung, Ji Hun Park, Seung-Kyung Hann
Vitiligo has a substantial negative impact on quality of life in affected patients, especially those with involvement of the face. However, the current system can barely distinguish between specific patterns of facial involvement except for the segmental type when focusing only on facial lesions. We classified facial vitiligo into three distinct subtypes using cluster analysis based on facial topography (n = 473): centrofacial vitiligo (72.9%), panfacial vitiligo (18.0%), and hairline vitiligo (9.1%). Centrofacial vitiligo was the most common type and is thought to comprise the typical facial involvement of generalized vitiligo...
March 6, 2018: Pigment Cell & Melanoma Research
Somya Abubucker, Bernard Cohen
A mother brought her 8-year-old daughter to our office for evaluation of vitiligo "down there". The skin eruption first appeared on her vulva a year earlier and was intermittently pruritic. The lesions were initially smaller and red, but had since lightened in color, coalesced, and had begun to spread to the perianal area. The patient's mother had received a call from her daughter's teacher who observed that her daughter was scratching the area and might be masturbating in class. WHAT IS YOUR DIAGNOSIS? HOW WOULD YOU TREAT THIS PATIENT?...
March 2018: Journal of Family Practice
Chao Niu, Li Yin, Haji Akber Aisa
The extracts of Ficuscarica L. and Psoralen corylifolia L. are traditional Uygur medicines for the treatment of vitiligo, and its active ingredients furocoumarins, were are found to be the most effective agents against this skin disorder nowadays. Therefore, a series of novel easter derivatives ( 8a - 8p ) of furocoumarin were designed and synthesized based on our previous research to improve this activity in the present study. The synthesized derivatives were biologically evaluated for melanin synthesis in murine B16 cells and the SAR (structure-activity relationship) was summarized...
March 6, 2018: International Journal of Molecular Sciences
Songtao Ben, Ying Jin, Stephanie A Santorico, Richard A Spritz
No abstract text is available yet for this article.
March 2, 2018: Journal of Investigative Dermatology
Sushama Sushama, Niharika Dixit, Ram Krishna Gautam, Pooja Arora, Ananta Khurana, Anubhuti Anubhuti
BACKGROUND: Vitiligo is an autoimmune disease associated with alteration in levels of various cytokines. However, there are very few studies in this regard. OBJECTIVES: To assess the serum levels of cytokines secreted by Th1 (IL-2, TNF-α), Th2 (IL-6), and Th17 cells (IL-17, IL-22) in patients with localized vitiligo and generalized vitiligo and to correlate their levels with the extent, duration, and activity of disease. MATERIAL AND METHODS: Sixty patients of vitiligo (30 each of localized and generalized) and 30 controls were recruited in the study...
March 4, 2018: Journal of Cosmetic Dermatology
Liya Jiang, Zhen Guo, Yulong Kong, Jianhua Liang, Yi Wang, Keyu Wang
Background: Vitiligo is a disorder caused by the loss of the melanocyte activity on melanin pigment generation. Studies show that oxidative-stress induced apoptosis in melanocytes is closely related to the pathogenesis of vitiligo. Glutamine is a well known antioxidant with anti-apoptotic effects, and is used in a variety of diseases. However, it is unclear whether glutamine has an antioxidant or anti-apoptotic effect on melanocytes. Aims: The aim of this study was to investigate the protective effects of glutamine on a human melanocyte oxidative stress model...
March 1, 2018: Indian Journal of Dermatology, Venereology and Leprology
Serena Gianfaldoni, Georgi Tchernev, Uwe Wollina, Jacopo Lotti, Miriam Rovesti, Francesca Satolli, Katlein França, Torello Lotti
Vitiligo is an acquired chronic hypopigmentary disorder, which usually stars in childhood. The Authors discuss a short review of the more innovative therapies for childhood vitiligo.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
Serena Gianfaldoni, Uwe Wollina, Georgi Tchernev, Jacopo Lotti, Katlein França, Torello Lotti
Vitiligo is an important skin disease of childhood, which may lead to deep psychological trauma, resulting in a poor quality of life and low self-esteem. The Authors discuss a short review of the more conventional therapies available for the treatment of vitiligo in children.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
Serena Gianfaldoni, Uwe Wollina, Michael Tirant, Georgi Tchernev, Jacopo Lotti, Francesca Satolli, Miriam Rovesti, Katlein França, Torello Lotti
An overview of unconventional therapies for vitiligo is presented. Some herbal compounds may be considered as valid therapeutic tools for the treatment of vitiligo.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
Serena Gianfaldoni, Georgi Tchernev, Uwe Wollina, Jacopo Lotti, Francesca Satolli, Katlein França, Miriam Rovesti, Torello Lotti
Vitiligo is an important skin disease of childhood. The authors briefly discuss the etiopathobiology, clinics and comorbidities of the disease.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
Serena Gianfaldoni, Georgi Tchernev, Jacopo Lotti, Uwe Wollina, Francesca Satolli, Miriam Rovesti, Katlein França, Torello Lotti
The authors show a brief overview of the vitiligo's unconventional therapies. A part for well-documented effectiveness of L-phenylalanine, PGE2 and antioxidant agents in the treatment of vitiligo, for the other therapeutical approaches more investigations are needed.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
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