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Vitiligo

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https://www.readbyqxmd.com/read/28631877/identification-of-chemical-components-in-baidianling-capsule-based-on-gc-ms-and-hplc-combined-with-fourier-transform-ion-cyclotron-resonance-mass-spectrometry
#1
Wenying Wu, Yu Chen, Binjie Wang, Xiaoyang Sun, Ping Guo, Xiaohui Chen
Baidianling Capsule, which is made from 16 Chinese herbs, has been widely used for treating vitiligo clinically. In this study, the sensitive and rapid method has been developed for the analysis of chemical components in Baidianling Capsule by gas chromatography with mass spectrometry in combination with retention indices and high-performance liquid chromatography combined with Fourier transform-ion cyclotron resonance mass spectrometry. Firstly, a total of 110 potential volatile compounds obtained from different extraction procedures including alkanes, alkenes, alkyne, ketones, ethers, aldehydes, alcohols, phenols, organic acids, esters, furan, pyrrole, acid amide, heterocycle and oxide were detected from Baidianling Capsule by gas chromatography with mass spectrometry, of which 75 were identified by mass spectrometry in combination with the retention index...
June 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28627461/8-methoxypsoralen-reduces-akt-phosphorylation-induces-intrinsic-and-extrinsic-apoptotic-pathways-and-suppresses-cell-growth-of-sk-n-as-neuroblastoma-and-sw620-metastatic-colon-cancer-cells
#2
Magdalena Bartnik, Adrianna Sławińska-Brych, Aleksandra Żurek, Martyna Kandefer-Szerszeń, Barbara Zdzisińska
ETHNOPHARMACOLOGICAL RELEVANCE: 8-methoxypsoralen (8-MOP) is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. 8-MOP together with UVA light is also used as an anticancer drug for the treatment of cutaneous T-cell lymphoma. However, furanocoumarins exert anticancer activity even without UV irradiation...
June 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28621124/duration-of-response-in-vitiligo-lesions-after-narrowband-uvb-phototherapy-combined-with-tacrolimus-ointment
#3
Dario Fai, Carlotta Fai, Nicoletta Cassano, Gino A Vena
No abstract text is available yet for this article.
August 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28621115/is-there-an-association-between-neurofibromatosis-type-i-and-vitiligo
#4
Emanuele Miraglia, Stefano Calvieri, Sandra Giustini
No abstract text is available yet for this article.
August 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28620923/home-phototherapy-in-vitiligo
#5
REVIEW
Tasneem F Mohammad, Narumol Silpa-Archa, James L Griffith, Henry W Lim, Iltefat H Hamzavi
Vitiligo is a disorder characterized by the development of depigmented macules and patches. Narrowband ultraviolet B phototherapy is a standard of care treatment and is used both as monotherapy and in combination with other treatment modalities to induce repigmentation. Although phototherapy is safe and effective, its use is limited due to the significant time commitment required and associated costs. Home phototherapy is a safe and effective alternative to make phototherapy more accessible to patients. However, it is often underutilized due to lack of physician experience and comfort as well as misconceptions regarding its safety and efficacy...
June 16, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28619557/current-and-emerging-treatments-for-vitiligo
#6
REVIEW
Michelle Rodrigues, Khaled Ezzedine, Iltefat Hamzavi, Amit G Pandya, John E Harris
Clinicians should be aware that vitiligo is not merely a cosmetic disease and that there are safe and effective treatments available for vitiligo. It is important to recognize common and uncommon presentations and those with active disease, as well as their implications for clinical management; these were discussed in the first article in this continuing medical education series. Existing treatments include topical and systemic immunosuppressants, phototherapy, and surgical techniques, which together may serve to halt disease progression, stabilize depigmented lesions, and encourage repigmentation...
July 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28619550/new-discoveries-in-the-pathogenesis-and-classification-of-vitiligo
#7
REVIEW
Michelle Rodrigues, Khaled Ezzedine, Iltefat Hamzavi, Amit G Pandya, John E Harris
Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Presentation patterns of vitiligo vary, and recognition of these patterns provides both diagnostic and prognostic clues...
July 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28604976/-progress-of-research-on-txndc5
#8
Jian Li, Xiaotian Chang
The protein encoded by TXNDC5 is a member the protein disulfide isomerase family, which has disulfide isomerase activity and can act as the molecular chaperone to reduce the synthesis of abnormal proteins. Its biological functions include anti-oxidation, promoting angiogenesis, taking part in cellular inflammation, and energy metabolism, etc. Studies have demonstrated that the expression of TXNDC5 is increased in many types of tumors including cervical carcinoma, gastric carcinoma and colorectal cancer. Moreover, TXNDC5 is also closely associated with rheumatoid arthritis, diabetes, hepatic steatosis and vitiligo...
June 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28598198/usefulness-of-ischemia-modified-albumin-in-predicting-oxidative-stress-in-patients-with-vitiligo
#9
Hatice Ataş, Murat Kocabıyık, Müzeyyen Gönül, Yasin Öztürk, Mustafa Kavutçu
AIM: To investigate the emphasis of oxidative stress in the pathogenesis of vitiligo through an evaluation of ischemia-modified albumin (IMA). Results/methodology: IMA was of higher statistical significance in patients than in the control group (IMA: 0.57 ± 0.2 vs 0.52 ± 0.2 ΔABSU; p < 0.0001). IMA (p < 0.0001; OR: 8.9; 95% CI = 3.1-26.1) was found as an independent predictor of oxidative stress. Increases in affected body surface area and age were found to be independent risk factors for IMA...
June 9, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28587417/a-comparative-study-for-the-short-term-effects-of-targeted-high-intensity-uvb-and-narrow-band-uvb-in-the-treatment-of-vitiligo
#10
Min Zhang, Wei-Yuan Ma
Vitiligo is a common acquired depigmentation disorder for which many treatments have previously been used with varying effects. The aim of the present study was to evaluate the efficacy and safety of targeted high-intensity (TH) and narrow band (NB) ultraviolet B light (UVB) for vitiligo treatment. A total of 33 patients with vitiligo were enrolled in the present study. Patients with a symmetrical or near-symmetrical distribution of lesions on their bodies were selected for the present study. For each patient, half of the body was treated with TH-UVB and the other with NB-UVB twice weekly over a period of 12 weeks (24 times total)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28584365/use-of-topical-corticosteroids-in-dermatology-an-evidence-based-approach
#11
REVIEW
Anupam Das, Saumya Panda
Topical corticosteroids (TCs) are the pillars of dermatotherapeutics. These drugs are the "magic molecules," provided they are used judiciously and appropriately, following a rational prescription. On exhaustive literature search in multiple databases, we found a significant evidence favoring the use of TCs in atopic eczema, localized vitiligo, psoriasis, chronic hand eczema, and localized bullous pemphigoid. However, contrary to conventional wisdom, we did not find any high-level scientific evidence in support of prescribing TCs in cutaneous lichen planus, sarcoidosis, and seborrhoeic dermatitis...
May 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28581823/importance-of-light-in-the-treatment-of-vitiligo-with-jak-inhibitors
#12
Deep Joshipura, Natalia Plotnikova, Ari Goldminz, Sandhya Deverapalli, Yana Turkowski, Alice Gottlieb, David Rosmarin
Vitiligo is an autoimmune pigmentary disorder characterized by depigmented patches of skin with a selective loss of melanocytes. Recent advances describe vitiligo as a T-helper (Th1) cell-mediated disease with elevated levels of IFN-γ and its associated chemokines CXCL9 and CXCL10 responsible for depigmentation. The Janus kinase (JAK) inhibitors have shown promise for the treatment of vitiligo with improved response in the sun-exposed areas. We propose viewing the treatment of vitiligo as a two-step process where the first part involves suppressing the immune system, followed by stimulation of the melanocytes to repigment the affected areas...
June 5, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28581234/oxidative-stress-and-high-mobility-group-box-1-hmgb1-protein-release-in-vitiligo
#13
M Becatti
No abstract text is available yet for this article.
June 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28579215/-vogt-koyanagi-harada-disease
#14
REVIEW
C Bonnet, J-B Daudin, D Monnet, A Brézin
Vogt-Koyanagi-Harada (VKH) disease is defined as a severe bilateral, chronic granulomatous panuveitis associated with serous retinal detachments, disk edema, and vitritis, with central nervous system, auditory, and integumentary manifestations. It is an autoimmune inflammatory condition mediated by T cells that target melanocytes in individuals genetically susceptible to the disease. Vogt-Koyanagi-Harada disease presents clinically in 4 different phases: prodromal, acute inflammatory, chronic, and recurrent, with extraocular manifestations including headache, meningitis, hearing loss, poliosis, and vitiligo...
May 31, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28577948/vitiligo-in-a-patient-with-lung-adenocarcinoma-treated-with-nivolumab-a-case-report
#15
Takeshi Uenami, Yuki Hosono, Mikako Ishijima, Masaki Kanazu, Yuki Akazawa, Yukihiro Yano, Masahide Mori, Toshihiko Yamaguchi, Soichiro Yokota
Nivolumab, an anti-programmed cell death-1 protein monoclonal antibody, is effective for treating patients with late-stage non-small-cell lung cancer. Immune checkpoint inhibitors such as nivolumab induce various kinds of immune-related adverse events, including vitiligo. Vitiligo has been reported in patients with melanoma but not lung cancer. We describe a 75-year-old man with lung adenocarcinoma, stage 4 with pleural and pericardial effusion, that progressed after first-line chemotherapy. Subsequently, he was treated with nivolumab as second-line therapy...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28577207/vitiligo-an-update-on-pathophysiology-and-treatment-options
#16
REVIEW
Reinhart Speeckaert, Nanja van Geel
The pathophysiology of vitiligo is becoming increasingly clarified. In non-segmental vitiligo, early factors include activation of innate immunity, inflammasome activation, oxidative stress, and loss of melanocyte adhesion. Nonetheless, the main mechanism leading to non-segmental vitiligo involves an immune-mediated destruction of melanocytes. Anti-melanocyte-specific cytotoxic T cells exert a central role in the final effector stage. Genetic research revealed a multi-genetic inheritance displaying an overlap with other autoimmune disorders...
June 2, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28575807/a-holistic-review-on-the-autoimmune-disease-vitiligo-with-emphasis-on-the-causal-factors
#17
REVIEW
Seema Patel, Abdur Rauf, Haroon Khan, Biswa Ranjan Meher, Syed Shams Ul Hassan
Vitiligo is an idiopathic systemic autoimmune disease affecting skin, hair and oral mucosa. This genetic yet acquired disease characterized by melanin loss is a cause of morbidity across all races. Though thyroid disturbance has been recognized as a key trigger of this pathology, an array of other factors plays critical role in its manifestation. Multiple hormones (corticotropin-releasing hormone, adrenocorticotropic hormone, α-melanocyte-stimulating hormone, melatonin, calcitriol, testosterone, estrogen), genes (Human leukocyte antigen (HLA), Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), Forkhead box D3 (FOXD3), Cluster of differentiation 117 (CD117), Estrogen receptor (ESR) 1, Cyclooxygenase-2 (COX2), Vitiligo-associated protein 1 (VIT1)), and lifestyle choices (stress, diet, cosmetic products, and medications) have been suspected as drivers of this disorder...
May 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28566906/multivariate-analysis-of-factors-associated-with-the-koebner-phenomenon-in-vitiligo-an-observational-study-of-381-patients
#18
Huma Khurrum, Khalid M AlGhamdi, Khalid M Bedaiwi, Naif Meshael AlBalahi
BACKGROUND: The Koebner phenomenon (KP) is a common entity observed in dermatological disorders. The reported incidence of KP in vitiligo varies widely. Although the KP is frequently observed in patients with viltiligo, the associated factors with KP has not been established yet. OBJECTIVE: The aim is to estimate the prevalence of KP in vitiligo patients and to investigate the associated factors with KP among vitiligo characteristics. METHODS: A cross-sectional observational study was conducted using 381 vitiligo patients...
June 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28566323/phototherapy-for-vitiligo
#19
(no author information available yet)
No abstract text is available yet for this article.
May 31, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28566321/effect-of-intensive-glucose-control-on-microvascular-events-in-people-with-type-2-diabetes
#20
(no author information available yet)
Effect of intensive glucose control on microvascular events in people with type 2 diabetes ● Febrile seizures in children: benefits and risks of prophylactic drug management More on gastric acid suppression and C difficile risk ● What next for the cardiovascular polypill? ● EMA recommends suspension of some generic drugs ● Phototherapy for vitiligo ● WHO targets medication-related errors.
May 31, 2017: Drug and Therapeutics Bulletin
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