keyword
https://read.qxmd.com/read/38403816/2-desaza-annomontine-c81-impedes-angiogenesis-through-reduced-vegfr2-expression-derived-from-inhibition-of-cdc2-like-kinases
#21
JOURNAL ARTICLE
T J Zech, A Wolf, M Hector, I Bischoff-Kont, G M Krishnathas, S Kuntschar, T Schmid, F Bracher, T Langmann, R Fürst
Angiogenesis is a crucial process in the progression of various pathologies, like solid tumors, wet age-related macular degeneration, and chronic inflammation. Current anti-angiogenic treatments still have major drawbacks like limited efficacy in diseases that also rely on inflammation. Therefore, new anti-angiogenic approaches are sorely needed, and simultaneous inhibition of angiogenesis and inflammation is desirable. Here, we show that 2-desaza-annomontine (C81), a derivative of the plant alkaloid annomontine previously shown to inhibit endothelial inflammation, impedes angiogenesis by inhibiting CDC2-like kinases (CLKs) and WNT/β-catenin signaling...
February 26, 2024: Angiogenesis
https://read.qxmd.com/read/38400739/extended-autologous-tracheal-replacement-by-a-novel-pedicled-thoraco-chondro-costal-flap-a-cadaveric-proof-of-concept
#22
JOURNAL ARTICLE
Kim de Frémicourt, Alain Wurtz, Dragos Georgescu, Matthieu Sarsam
OBJECTIVES: Our aim was to report an anatomic model of an autologous flap based on the internal thoracic blood supply: the pedicled thoraco-chondro-costal flap; and establish the feasibility of various types of extended tracheal replacement with this novel flap, according to a newly-proposed topographic classification. METHODS: In cadaveric model, a cervicotomy combined with median sternotomy was performed. The incision was extended laterally to expose the chest wall...
February 23, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38393179/effects-of-the-heterodimeric-neurotoxic-phospholipase-a-2-from-the-venom-of-vipera-nikolskii-on-the-contractility-of-rat-papillary-muscles-and-thoracic-aortas
#23
JOURNAL ARTICLE
Alexey Averin, Vladislav Starkov, Victor Tsetlin, Yuri Utkin
Phospholipases A2 (PLA2 s) are a large family of snake toxins manifesting diverse biological effects, which are not always related to phospholipolytic activity. Snake venom PLA2 s (svPLA2 s) are extracellular proteins with a molecular mass of 13-14 kDa. They are present in venoms in the form of monomers, dimers, and larger oligomers. The cardiovascular system is one of the multiple svPLA2 targets in prey organisms. The results obtained previously on the cardiovascular effects of monomeric svPLA2 s were inconsistent, while the data on the dimeric svPLA2 crotoxin from the rattlesnake Crotalus durissus terrificus showed that it significantly reduced the contractile force of guinea pig hearts...
February 10, 2024: Toxins
https://read.qxmd.com/read/38386180/functional-and-perfusion-changes-associated-with-silicone-oil-tamponade-after-macula-off-rhegmatogenous-retinal-detachment-surgery-an-optical-coherence-tomography-angiography-microperimetry-study
#24
JOURNAL ARTICLE
Ghada A Nassar, Hebatalla Samir Makled, Maha Mohamed Youssef, Lameece Moustafa Hassan
PURPOSE: The current study utilizes microperimetry and optical coherence tomography angiography (OCTA) to assess the optic nerve head vasculature, retinal microvasculature, and retinal sensitivity before and after silicone oil (SO) removal. METHODS: This prospective observational case series study involved 30 eyes subjected to silicone oil endotamponade. Microperimetry and OCTA were utilized to assess the vascular density (VD) of the macula and optic nerve head, as well as the retinal sensitivity (RS), of the participants preoperatively and 1 month following SO removal...
February 22, 2024: International Ophthalmology
https://read.qxmd.com/read/38379198/perioperative-and-anesthetic-considerations-in-vascular-rings-and-slings
#25
REVIEW
Michael Wadle, Denise Joffe, Carl Backer, Faith Ross
Vascular rings represent an increasingly prevalent and diverse set of congenital malformations in which the aortic arch and its primary branches encircle and constrict the esophagus and trachea. Perioperative management varies significantly based on the type of lesion, its associated comorbidities, and the compromise of adjacent structures. Multiple review articles have been published describing the scope of vascular rings and relevant concerns from a surgical perspective. This review seeks to discuss the perioperative implications and recommendations of such pathology from the perspective of an anesthesia provider...
February 20, 2024: Seminars in Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38378189/contralateral-thoracotomy-with-extracorporeal-circulation-for-reoperative-resection-of-a-kommerell-diverticulum
#26
JOURNAL ARTICLE
Carlo R Bartoli, Clement J Rajakumar, James R Elmore, Gerhard Ziemer
Reoperative vascular ring surgery is uncommon. Standard redo ipsilateral thoracotomy may present technical challenges and risks. We describe a patient with right aortic arch, aberrant left subclavian artery, and a Kommerell diverticulum in whom previous vascular ring division via left thoracotomy did not relieve dysphagia. Three years after the unsuccessful operation, left subclavian-carotid transposition via supraclavicular incision followed by resection of the Kommerell diverticulum via right thoracotomy with extracorporeal circulation relieved symptoms...
February 20, 2024: World Journal for Pediatric & Congenital Heart Surgery
https://read.qxmd.com/read/38375349/explantation-of-an-alto-abdominal-stent-graft
#27
Carl T Schoephoerster, Mohammad H Rajaei, Peter J Rossi
Explantation of traditional infrarenal aortic endografts has been previously described, and explanation of aortic endografts with standard suprarenal fixation at our center has been well defined. However, to the best of our knowledge, no cases have been reported on explantation of endografts with polymer rings present to facilitate the proximal seal. By obtaining full thoracoabdominal exposure with supraceliac clamping and opening the entire aorta along the graft, we were able to successfully explant the ALTO stent graft with polymer rings...
April 2024: Journal of Vascular Surgery Cases and Innovative Techniques
https://read.qxmd.com/read/38374995/overexpression-of-vegf%C3%AE-as-a-biomarker-of-endothelial-dysfunction-in-aortic-tissue-of-%C3%AE-gal-tg-ko-mice-and-its-upregulation-in-the-serum-of-patients-with-fabry-s-disease
#28
JOURNAL ARTICLE
N Lund, H Wieboldt, L Fischer, N Muschol, F Braun, T Huber, D Sorriento, G Iaccarino, K Müllerleile, E Tahir, G Adam, P Kirchhof, L Fabritz, M Patten
INTRODUCTION: Fabry's disease is an X-linked lysosomal storage disorder caused by reduced activity of α-galactosidase A (GAL), leading to premature death on account of renal, cardiac, and vascular organ failure. Accumulation of the GAL substrate globotriaosylceramide (Gb3) in endothelial and smooth muscle cells is associated with early vascular cell damage, suggesting endothelial dysfunction as a driver of cardiorenal organ failure. Here, we studied the vascular expression of the key angiogenic factors, VEGFα and its antagonist angiostatin, in Fabry α-GAL-Tg/KO mice and determined circulating VEGFα and angiostatin serum levels in patients with Fabry's disease and healthy controls...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38373901/efficacy-and-safety-of-intravitreal-injections-of-conbercept-for-the-treatment-of-idiopathic-choroidal-neovascularization
#29
JOURNAL ARTICLE
Gaixia Zhai, Yuanzhen Su, Shaopeng Wang, Hui Lu, Na Liu
BACKGROUND: To determine the efficacy and safety of intravitreally injected conbercept, a vascular endothelial growth factor receptor fusion protein, for the treatment of idiopathic choroidal neovascularization (ICNV). METHODS: This retrospective study analyzed outcomes in 40 patients (40 eyes) with ICNV who received intravitreal injections of conbercept 0.5 mg (0.05 ml) and were followed up for at least 12 months. All patients underwent full ophthalmic examinations, including best-corrected vision acuity (BCVA), intraocular pressure (IOP), slit-lamp examination, color fundus photography, optical coherence tomography angiography, multifocal electroretinogram, and fundus fluorescence angiography, if necessary, at baseline and after 1, 3, 6, and 12 months...
February 19, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38358640/chemical-characterization-of-phoenix-dactylifera-l-seeds-and-their-beneficial-effects-on-the-vascular-response-in-hypertensive-rats
#30
JOURNAL ARTICLE
Fredi Cifuentes, Javier Palacios, Daniel Asunción-Alvarez, Ricardo D G de Albuquerque, Mario J Simirgiotis, Adrián Paredes, Chukwuemeka R Nwokocha, Raha Orfali, Shagufta Perveen
Although Phoenix dactylifera dates are traditionally consumed for their health benefits, no research has been done on the vascular response in hypertensive animals. This study evaluated the vascular relaxation of hydroalcoholic extracts from seeds of three varieties of P. dactylifera; Sukkari seed (SS), Ajwa seed (AS), and Mabroom seed (MS) on L-NAME-induced hypertension and spontaneously hypertensive rats (SHR). Results showed that all extracts (10 µg/mL) caused relaxations higher than 60% in the aortic rings precontracted with 10- 6 M phenylephrine in normotensive rats, the SS extract was the most potent...
February 15, 2024: Plant Foods for Human Nutrition
https://read.qxmd.com/read/38351286/amphetamine-increases-vascular-permeability-by-modulating-endothelial-actin-cytoskeleton-and-no-synthase-via-par-1-and-vegf-r
#31
JOURNAL ARTICLE
Julia Böttner, Tina Fischer-Schaepmann, Sarah Werner, Sarah Knauth, Heinz-Georg Jahnke, Holger Thiele, Petra Büttner
Abuse of amphetamine-type stimulants is linked to cardiovascular adverse effects like arrhythmias, accelerated atherosclerosis, acute coronary syndromes and sudden cardiac death. Excessive catecholamine release following amphetamine use causes vasoconstriction and vasospasms, over time leading to hypertension, endothelial dysfunction or even cardiotoxicity. However, immediate vascular pathomechanisms related to amphetamine exposure, especially endothelial function, remain incompletely understood and were analyzed in this study...
February 13, 2024: Scientific Reports
https://read.qxmd.com/read/38349343/microvascular-abnormalities-induced-by-hand-transmitted-vibration-reflects-in-finger-systolic-blood-pressure-a-cross-sectional-study-in-china
#32
JOURNAL ARTICLE
Maosheng Yan, Hanjun Zheng, Qian Liu, Bin Xiao, Chengmin Wang, Yanxia Jia, Siyu Pan
OBJECTIVE: Local vibration can cause microcirculatory abnormalities such as blood stasis and symmetrical intermittent digital artery vasospasm. Finger SBP (FSBP) measurement is a potential way of assessing vascular components. This study aims to comprehensively investigate the relationship between the occurrence of the vibration-induced white finger (VWF) and changes in FSBP and then set the application value of FSBP measurements in the early diagnosis of VWF. METHODS: All samples were judgmental sampling from one factory...
February 13, 2024: Blood Pressure Monitoring
https://read.qxmd.com/read/38346904/brief-insight-into-the-in-silico-properties-structure-activity-relationships-and-biotransformation-of-fruquintinib-an-anticancer-drug-of-a-new-generation-containing-a-privileged-benzofuran-scaffold
#33
JOURNAL ARTICLE
Dominika Nádaská, Lucia Hudecova, Gustáv Kováč, Ivan Malík
Current trends in drug design notably consider so-called privileged scaffolds as the core structural fragments with decisive impact on affinity to properly chosen biological targets, potency, selectivity and toxicological characteristics of drugs and prospective drug candidates. Fruquintinib (1) is a novel synthetic selective inhibitor of vascular endothelial growth factor receptor (VEGFR) isoforms, i.e., VEGFR-1, VEGFR-2 and VEGFR-3. The therapeutic agent (1) consists of a flat bicyclic heteroaromatic ring, in which two nitrogens are suitablyincorporated, a core bicyclic heteroaromatic ring - privileged (substituted) benzofuran scaffold, and a pair of hydrogen bond (H-bond) donor and acceptor group, i...
2024: Ceská a Slovenská Farmacie
https://read.qxmd.com/read/38344328/effects-of-gold-nanoparticles-phytoreduced-with-cornus-mas-l-extract-on-the-aorta-wall-function-in-rats-with-hyperlipid-diet-a-study-on-isolated-aortic-rings
#34
JOURNAL ARTICLE
Remus Moldovan, Daniela-Rodica Mitrea, Irina Chiş, Luminiţa David, Simona Clichici
BACKGROUND: Vascular reactivity may be influenced by the dysfunction of the perivascular adipose tissue (PVAT) that occurs after a prolonged high fat diet (HFD). AIM: The aim of this study was to investigate the vascular responses in rats with prolonged HFD after the administration of Cornus mas L. extract as a simple solution or as a reducing agent for gold nanoparticles (AuNPs). METHODS: Sprague-Dawley adult female rats (21 animals) were randomly allocated into three groups (n=7) and received for 9 months hyperlipid diet, the last month with treatment administered through oral gavage, 0...
January 2024: Medicine and pharmacy reports
https://read.qxmd.com/read/38337754/associated-anomalies-and-outcome-in-patients-with-prenatal-diagnosis-of-aortic-arch-anomalies-as-aberrant-right-subclavian-artery-right-aortic-arch-and-double-aortic-arch
#35
JOURNAL ARTICLE
Roland Axt-Fliedner, Asia Nazar, Ivonne Bedei, Johanna Schenk, Maleen Reitz, Stefan Rupp, Christian Jux, Aline Wolter
We aimed to evaluate retrospectively associated anomalies and outcome in prenatal aortic arch anomalies (AAAs). We included ninety patients with aberrant right subclavian artery (ARSA), right aortic arch (RAA) with mirror image branching (RAA-mirror) or aberrant left subclavian artery (RAA-ALSA) and double aortic arch (DAA) between 2011 and 2020. In total, 19/90 (21.1%) had chromosomal anomalies, the highest rate being within the ARSA subgroup (17/46, 37%). All (13/13) of the RAA-mirror subgroup, 10/27 (37...
January 23, 2024: Diagnostics
https://read.qxmd.com/read/38335755/identification-of-new-multi-substituted-1h-pyrazolo-3-4-c-pyridin-7-6h-ones-as-soluble-guanylyl-cyclase-sgc-stimulators-with-vasoprotective-and-anti-inflammatory-activities
#36
JOURNAL ARTICLE
Dionysios-Panagiotis Kintos, Konstantinos Salagiannis, Antonis Sgouros, Sotiris S Nikolaropoulos, Stavros Topouzis, Manolis A Fousteris
Herein, we describe the rational design, synthesis and in vitro functional characterization of new heme-dependent, direct soluble guanylyl cyclase (sGC) agonists. These new compounds bear a 1H-pyrazolo[3,4-c]pyridin-7(6H)-one skeleton, modified to enable efficient sGC binding and stimulation. To gain insights into structure-activity relationships, the N6-alkylation of the skeleton was explored, while a pyrimidine ring, substituted with various C5'-polar groups, was installed at position C3. Among the newly synthesized 1H-pyrazolo[3,4-c]pyridin-7(6H)-ones, derivatives 14b, 15b and 16a display characteristic features of sGC "stimulators" in A7r5 vascular smooth muscle cells in vitro...
February 2, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38331336/3-3-o-dimethylquercetin-a-bi-functional-vasodilator-isolated-from-green-propolis-of-the-caatinga-mimosa-tenuiflora
#37
JOURNAL ARTICLE
Ninh The Son, Beatrice Gianibbi, Alice Panti, Ottavia Spiga, Jairo Kenupp Bastos, Fabio Fusi
In the search for novel, bi-functional compounds acting as CaV 1.2 channel blockers and K+ channel stimulators, which represent an effective therapy for hypertension, 3,3'-O-dimethylquercetin was isolated for the first time from Brazilian green propolis. Its effects were investigated through electrophysiological, functional, and computational approaches. In rat tail artery myocytes, 3,3'-O-dimethylquercetin blocked Ba2+ currents through CaV 1.2 channels (IBa1.2 ) in a concentration-dependent manner, with the inhibition being reversed upon washout...
February 6, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38328445/enhanced-hemocompatibility-and-rapid-magnetic-anastomosis-of-electrospun-small-diameter-artificial-vascular-grafts
#38
JOURNAL ARTICLE
Peng Liu, Xin Liu, Lifei Yang, Yerong Qian, Qiang Lu, Aihua Shi, Shasha Wei, Xufeng Zhang, Yi Lv, Junxi Xiang
Background: Small-diameter (<6 mm) artificial vascular grafts (AVGs) are urgently required in vessel reconstructive surgery but constrained by suboptimal hemocompatibility and the complexity of anastomotic procedures. This study introduces coaxial electrospinning and magnetic anastomosis techniques to improve graft performance. Methods: Bilayer poly(lactide-co-caprolactone) (PLCL) grafts were fabricated by coaxial electrospinning to encapsulate heparin in the inner layer for anticoagulation. Magnetic rings were embedded at both ends of the nanofiber conduit to construct a magnetic anastomosis small-diameter AVG...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38328241/p66shc-mediates-sumo2-induced-endothelial-dysfunction
#39
Jitendra Kumar, Shravan K Uppulapu, Sujata Kumari, Kanika Sharma, William Paradee, Ravi Prakash Yadav, Vikas Kumar, Santosh Kumar
UNLABELLED: Sumoylation is a post-translational modification that can regulate different physiological functions. Increased sumoylation, specifically conjugation of SUMO2/3 (small ubiquitin like modifier 2/3), is detrimental to vascular health. However, the molecular mechanism mediating this effect is poorly understood. Here, we demonstrate that SUMO2 modifies p66Shc, which impairs endothelial function. In endothelial cells, knockdown of p66Shc blunted SUMO2-induced increases in reactive oxygen species and inflammation...
January 26, 2024: bioRxiv
https://read.qxmd.com/read/38324799/flap-of-the-sternocephalicus-muscle-in-the-repair-of-a-partial-defect-in-the-trachea-of-a-rabbit-oryctolagus-cuniculus
#40
JOURNAL ARTICLE
Gustavo Fernandes, Ariadne Rein, Gabriel Luiz Montanhim, Marcelo Carrijo da Costa, Marcella Dall'Agnol Leite, Nicolle Pereira Soares, Paola Castro Moraes
PURPOSE: The current study aimed at evaluating the repair of a partial defect of the trachea with a muscle flap, an advanced technique that employs combined suture patterns. METHODS: Sixteen healthy male New Zealand white rabbits were used as an experimental model. A partial defect in the trachea within the ventral region of the fourth to eighth tracheal ring was created. Subsequently, repair was initiated with a flap of the sternocephalicus muscle. The animals were divided into four groups for postoperative evaluation using clinical, tracheoscopic, and histopathological analyses...
2024: Acta Cirúrgica Brasileira
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