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https://www.readbyqxmd.com/read/29128791/acpa-and-jwh-133-modulate-the-vascular-tone-of-superior-mesenteric-arteries-through-cannabinoid-receptors-bkca-channels-and-nitric-oxide-dependent-mechanisms
#1
Evelyn López-Dyck, Felipa Andrade-Urzúa, Alejandro Elizalde, Tania Ferrer-Villada, Adan Dagnino-Acosta, Miguel Huerta, Zyanya Osuna-Calleros, Cinthia Rangel-Sandoval, Enrique Sánchez-Pastor
BACKGROUND: Some cannabinoids, a family of compounds derived from Cannabis sativa (marijuana), have previously shown vasodilator effects in several studies, a feature that makes them suitable for the generation of a potential treatment for hypertension. The mechanism underlying this vasodilator effect in arteries is still controversial. In this report, we explored how the synthetic cannabinoids ACPA (CB1-selective agonist) and JWH-133 (CB2-selective agonist) regulate the vascular tone of rat superior mesenteric arteries...
July 1, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29127234/ppar%C3%AE-agonists-acutely-inhibit-calcium-independent-pla2-to-reduce-h2o2-induced-contractions-in-aortae-of-spontaneously-hypertensive-rats
#2
Hui Chen, Ricky Y K Man, Susan W S Leung
Hypertension is associated with endothelial dysfunction, which favors the release of endothelium-derived contracting factors, including vasoconstrictor prostanoids and reactive oxygen species. Peroxisome proliferator-activated receptor α (PPARα) agonists, clinically used as lipid lowering drugs, possess antioxidant properties and exert beneficial effects in the vascular system. The present study aimed to identify the mechanism(s) underlying the acute effects of the PPARα agonists, Wy14643 and fenofibate, on endothelium-dependent contractions, in particular, those related to oxidative stress, in the aorta of the spontaneously hypertensive rat (SHR)...
November 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29127233/vascular-endothelial-function-masks-increased-sympathetic-vasopressor-activity-in-rats-with-metabolic-syndrome
#3
Sylvain Battault, Cindy Meziat, Alessandro R Nascimento, Laura Braud, Sandrine Gayrard, Christian Legros, Frederic De Nardi, Jocelyne Drai, Olivier Cazorla, Jérôme Thireau, Gregory Meyer, Cyril Reboul
OBJECTIVE: Sympathetic hyperactivation, a common feature of obesity and metabolic syndrome, is a key trigger of hypertension. However, some obese subjects with autonomic unbalance present a dissociation between sympathetic activity mediated vasoconstriction and increased blood pressure. Here, we aimed to determine in a rat model of metabolic syndrome, whether the endothelium eNOS-NO pathway contribute to counteract the vasopressor effect of the sympathetic system. METHODS: Rats were fed a high fat and high sucrose diet for 15 weeks (HFS)...
November 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29126066/formaldehyde-regulates-vascular-tensions-through-nitric-oxide-cgmp-signaling-pathway-and-ion-channels
#4
Quanxi Zhang, Peiru Tian, Miaomiao Zhai, Xiaodong Lei, Zhenhua Yang, Yan Liu, Mengting Liu, Hao Huang, Xiri Zhang, Xu Yang, Yun Zhao, Ziqiang Meng
Formaldehyde (FA) has been linked to the detrimental cardiovascular effects. Here, we explored the effects and mechanisms of FA on rat aortas both in vivo and in vitro. The results presented that FA evidently lowered the blood pressures of rats. The expression levels of BKCa subunits α and β1 and iNOS of the aortas were up-regulated by FA in vivo. However, FA markedly reduced the levels of Cav1.2 and Cav1.3, which are the subunits of L-Ca(2+) channel. Furthermore, the contents of NO, cGMP and iNOS in the aortas were augmented by FA...
November 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/29122658/endothelium-derived-contraction-in-a-model-of-rheumatoid-arthritis-is-mediated-via-angiotensin-ii-type-1-receptors
#5
Kayleigh Hamilton, Lynette Dunning, William R Ferrell, John C Lockhart, Andrew MacKenzie
A role for endothelium-derived constricting factors (EDCF), and the angiotensin II type 1 receptor (AT1R) pathway, in the vascular impairment found in the rat Freund's complete adjuvant (FCA)-model of rheumatoid arthritis (RA) was examined. FCA arthritis was induced in rats±losartan. Vehicle-treated rats served as controls. Knee-joint swelling and red blood cell (RBC) aggregation were measured as indicators of inflammation and endothelium reactivity assessed by response to acetylcholine (ACh) on aortic rings...
November 6, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/29115861/postnatal-overnutrition-affects-metabolic-and-vascular-function-reflected-by-physiological-and-histological-changes-in-the-aorta-of-adult-wistar-rats
#6
Gerardo Sánchez-García, Laura Del Bosque-Plata, Enrique Hong
Rigorous nutritional care during early life leads to healthy adulthood. Cardiovascular and metabolic disorders, the most prevalent clinical challenges worldwide, are epidemiologically linked to poor nutritional habits throughout life. We aimed to understand whether postnatal overnutrition (PO) initiated during lactation affects metabolic markers and vascular function later in life. To test this hypothetical effect, we studied a PO Wistar rat model based on adjusting litter size at the third day of age to three pups and eight for the control group (C)...
November 8, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29112589/androgens-mediate-%C3%AE-adrenergic-vasorelaxation-impairment-via-adenylyl-cyclase
#7
O A López-Canales, M C Castillo-Hernández, H Vargas-Robles, A Rios, J S López-Canales, B Escalante
Cardiovascular disease development has been associated with gender differences, suggesting that sex hormones are implicated in vascular function and development of hypertension. Vascular tone comparison at different stages of rat growth represents a good model to study testosterone-related vascular response. We explored the role of testosterone in modulation of age-dependent impaired β-adrenergic vasodilation.The 3 week-old male Sprague-Dawley rats were sorted in 3 week-old rats without any manipulation and 3 week-old rats treated with testosterone...
October 31, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29111778/multi-carotenoids-at-physiological-levels-inhibit-vegf-induced-tube-formation-of-endothelial-cells-and-the-possible-mechanisms-of-action-both-in-vitro-and-ex-vivo
#8
Chien-Hao Huang, Chin-Shiu Huang, Miao-Lin Hu, Cheng-Hung Chuang
Carotenoids have been shown to exhibit antiangiogenic activities. Several studies have indicated that carotenoids used in combination were more effective on antioxidation and anticancer actions than carotenoids used singly. However, it is unclear whether multi-carotenoids have antiangiogenic effects. We investigated the effects of multi-carotenoids at physiological plasma levels of Taiwanese (abbreviated as MCT, with a total of 1.4 μM) and Americans (abbreviated as MCA, with a total of 1.8 μM), and of post-supplemental plasma levels (abbreviated as HMC with a total of 3...
November 7, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29111468/the-therapeutic-value-of-protein-de-nitrosylation-in-experimental-septic-shock
#9
Patrícia O Benedet, Angela C O Menegatti, Muryel C Gonçalves, Hernán Terenzi, Jamil Assreuy
Cardiovascular dysfunction and organ damage are hallmarks of sepsis and septic shock. Protein S-nitrosylation by nitric oxide has been described as an important modifier of protein function. We studied whether protein nitrosylation/denitrosylation would impact positively in hemodynamic parameters of septic rats. Polymicrobial sepsis was induced by cecal ligation and puncture. Female Wistar rats were treated with increasing doses of DTNB [5,5'-dithio-bis-(2-nitrobenzoic acid)] 30min before or 4 or 12h after sepsis induction...
October 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29110838/cd13-as-target-for-tissue-factor-induced-tumor-vascular-infarction-in-small-cell-lung-cancer
#10
Lars Henning Schmidt, Janine Stucke-Ring, Caroline Brand, Christoph Schliemann, Saliha Harrach, Thomas Muley, Esther Herpel, Torsten Kessler, Michael Mohr, Dennis Görlich, Michael Kreuter, Georg Lenz, Eva Wardelmann, Michael Thomas, Wolfgang E Berdel, Christian Schwöppe, Wolfgang Hartmann
OBJECTIVES: Zinc-binding protease aminopeptidase N (CD13) is expressed on tumor vascular cells and tumor cells. It represents a potential candidate for molecular targeted therapy, e.g. employing truncated tissue factor (tTF)-NGR, which can bind CD13 and thereby induce tumor vascular infarction. We performed a comprehensive analysis of CD13 expression in a clinically well characterized cohort of patients with small cell lung cancer (SCLC) to evaluate its potential use for targeted therapies in this disease...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29110592/recent-developments-on-phenstatins-as-potent-antimitotic-agents
#11
Xing Chen, Shi-Meng Wang, Gajjela Bharath Kumar, Grant A L Bare, Jing Leng, Syed Nasir Abbas Bukhari, Hua-Li Qin
Phenstatin and their derivatives display remarkable antiproliferative activity toward a wide variety of preclinical tumor models. Phenstatins inhibit tubulin polymerization through their interaction at the colchicine binding site of microtubules and arrest the G2/M phase of the cell cycle. Moreover, the structural simplicity and excellent stability of phenstatins offer a stimulating premise for developing various derivatives with profound antimitotic activity and excellent cytotoxicity. In addition, phenstatin derivatives are undergoing clinical evaluation as vascular targeting/disrupting agents and also exhibit direct antiangiogenic properties...
November 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29107024/relaxant-effect-of-the-prostacyclin-analogue-iloprost-on-isolated-human-radial-artery-an-approach-for-the-reversal-of-graft-spasm
#12
Ersoy Engin, F İlkay Alp Yildirim, Deniz Kalelі Durman, Suat Nail Ömeroğlu, Deniz Göksedef, Önder Teskіn, Ozan Onur Balkanay, Gökhan İpek, B Sönmez Uydeş Doğan
Radial artery graft spasm in the perioperative or postoperative period of coronary bypass surgery necessitates urgent treatment due to risk of graft failure and mortality. Herein, we evaluated the effect of iloprost, a prostacyclin (PGI2) analogue, against the contractions produced by noradrenaline and potassium chloride on isolated human radial artery. Following the determination of endothelial and vascular relaxing capacities of the arteries, iloprost (10(-9)M-10(-6)M) was cumulatively applied on rings precontracted submaximally with the spasmogens...
October 26, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29104545/the-adenosine-hypothesis-revisited-modulation-of-coupling-between-myocardial-perfusion-and-arterial-compliance
#13
Geoffrey P Dobson, Aryadi Arsyad, Hayley L Letson
For over four decades the thoracic aortic ring model has become one of the most widely used methods to study vascular reactivity and electromechanical coupling. A question that is rarely asked, however, is what function does a drug-mediated relaxation (or contraction) in this model serve in the intact system? The physiological significance of adenosine relaxation in rings isolated from large elastic conduit arteries from a wide range of species remains largely unknown. We propose that adenosine relaxation increases aortic compliance in acute stress states and facilitates ventricular-arterial (VA) coupling, and thereby links compliance and coronary artery perfusion to myocardial energy metabolism...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29093568/experimental-preeclampsia-in-rats-affects-vascular-gene-expression-patterns
#14
Simone V Lip, Anne Marijn van der Graaf, Marjon J Wiegman, Sicco A Scherjon, Mark V Boekschoten, Torsten Plösch, Marijke M Faas
Normal pregnancy requires adaptations of the maternal vasculature. During preeclampsia these adaptations are not well established, which may be related to maternal hypertension and proteinuria. The effects of preeclampsia on the maternal vasculature are not yet fully understood. We aimed to evaluate gene expression in aortas of pregnant rats with experimental preeclampsia using a genome wide microarray. Aortas were isolated from pregnant Wistar outbred rats with low-dose LPS-induced preeclampsia (ExpPE), healthy pregnant (Pr), non-pregnant and low-dose LPS-infused non-pregnant rats...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29083019/pulmonary-function-tests-leading-to-the-diagnosis-of-vascular-malformations-in-school-aged-children
#15
Beata Kusak, Ewa Cichocka-Jarosz, Urszula Jedynak-Wąsowicz, Grzegorz Lis
Vascular rings are congenital defects of great vessels. They cause compression of the trachea or/and the esophagus and therefore result in symptoms like inspiratory stridor, cough, wheezing, recurrent respiratory tract infections or dysphagia. In some cases, the correct diagnosis can be delayed for many years, especially when vascular rings produce less severe symptoms or symptoms mimicking other diseases (most of all asthma). In this article, we would like to emphasis the usefulness of pulmonary function test (spirometry) in the initial diagnosis of vascular rings in school-aged children, as well as the importance of spirometry in evaluating patients with asthma presumption...
October 30, 2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29080353/h2-p-a-honokiol-derivative-exerts-anti-angiogenesis-effects-via-c-myc-signaling-pathway-in-glioblastoma
#16
Ting Wang, Wei Chen, Jialin Wu
H2-P, a derivative of honokiol , was first synthesized in our laboratory. Compared with honokiol, H2-P has even high anti-tumor activity. In the present study, we evaluated the ability of H2-P to inhibit the survival rate in 4 gliomas cell lines. The result showed that H2-P could significantly inhibit proliferation of gliomas cells in a dose-dependent manner (IC50U251 =9.03 nM, IC50SHG-44 =10.74 nM, IC50U78 =19.87 nM and IC50c6 =22.56 nM). Furthermore, to determine the mechanism underlying the anti-gliomas effects of H2-P, 6 kinase activities was detected by Z'-LYTE™ system...
October 28, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29078076/involvement-of-bilitranslocase-and-beta-glucuronidase-in-the-vascular-protection-by-hydroxytyrosol-and-its-glucuronide-metabolites-in-oxidative-stress-conditions
#17
Julien Peyrol, Grégory Meyer, Philippe Obert, Olivier Dangles, Laurent Pechère, Marie-Josèphe Amiot, Catherine Riva
Olive oil vascular benefits have been attributed to hydroxytyrosol (HT). However, HT biological actions are still debated because it is extensively metabolized into glucuronides (GCs). The aim of this study was to test HT and GC vasculoprotective effects and the underlying mechanisms using aorta rings from 8-week-old male Wistar rats. In the absence of oxidative stress, incubation with 100 μM HT or GC for 5 min did not exert any vasorelaxing effect and did not influence the vascular function. Conversely, in condition of oxidative stress [upon incubation with 500 μM tert-butylhydroperoxide (t-BHP) for 30 min], preincubation with HT or GC improved acetylcholine-induced vasorelaxation compared with untreated samples (no t-BHP)...
October 3, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29074305/scleral-lens-after-intracorneal-ring-segments-in-patients-with-keratoconus
#18
Varsha M Rathi, Preeji S Mandathara, Srikanth Dumpati, Virender S Sangwan
BACKGROUND: To report the use of scleral lens (ScCL) to improve vision in patients having keratoconus who had intracorneal ring segment (ICRS) surgery. METHODS: Two eyes of two keratoconus patients fitted with ScCL (PROSE - prosthetic replacement of the ocular surface ecosystem, USA) after having undergone ICRS surgery are reported as noncomparative interventional case series. The ICRS implanted were INTACs and kerarings. Indications, visual acuity with ScCL, complications and follow-up are reported...
October 24, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29072489/effects-of-losartan-on-vasomotor-function-and-canonical-transient-receptor-potential-channels-in-the-aortas-of-sinoaortic-denervation-rats
#19
Minlie Liang, Wenliang Zhong, Fei Miao, Hongchao Wu, Yingfeng Liu
Increased short-term blood pressure variability (BPV) is strongly correlated with target organ damage. However, the molecular mechanisms underlying abnormal BPV-induced organ damage and effective therapeutic targets are poorly understood. The purpose of this study was to investigate the effects of losartan on vasomotor function and canonical transient receptor potential (TRPC) channels in the aortas of rats with arterial pressure lability induced by sinoaortic denervation (SAD). SAD was performed in male Sprague-Dawley rats at the age of 10 weeks...
October 26, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29067117/spontaneously-hypertensive-rats-are-sensitive-to-thoracic-aorta-damage-induced-by-a-hot-and-humid-environment
#20
Tao Xu, Fadong Liu, Yan Luo, Lingqin Zhu, Jianguo Niu, Guanghua Li
The purpose of this study was to investigate the effect of a hot and humid environment on thoracic aorta damage in spontaneously hypertensive rats (SHRs). Wistar-Kyoto (WKY) rats were randomly divided into three groups (n=8 in each group): Control group (WKY-CN), heat exposure for 8 h group (WKY-8) and heat exposure for 24 h group (WKY-24). The CN group was exposed to room temperature (24°C); WKY-8 and WKY-24 group were exposed to heat (32°C) and 65% relative humidity for 8 and 24 h, respectively. Accordingly, SHRs were randomly divided into three groups (n=8 each group): SHR-CN, SHR-8 and SHR-24...
November 2017: Experimental and Therapeutic Medicine
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