keyword
MENU ▼
Read by QxMD icon Read
search

Vascular ring

keyword
https://www.readbyqxmd.com/read/28938516/naturally-occurring-anthocyanin-cyanidin-3-rutinoside-possesses-inherent-vasorelaxant-actions-and-prevents-methylglyoxal-induced-vascular-dysfunction-in-rat-aorta-and-mesenteric-arterial-bed
#1
Thavaree Thilavech, Mahinda Y Abeywardena, Michael Adams, Julie Dallimore, Sirichai Adisakwattana
Cyanidin-3-rutinoside (C3R) possesses anti-oxidant, anti-inflammatory and anti-glycation properties. Methylglyoxal (MG), a highly reactive dicarbonyl aldehyde by-product of glycolysis, is a precursor of advanced glycation end products and contributes to vascular dysfunction, particularly during hyperglycemia. We investigated the possible inherent vasoactivity of C3R, and its effectiveness against MG-induced vascular abnormalities in isolated blood vessel preparations from male Wistar Kyoto rat. C3R induced vasorelaxation concentration-dependently in aortic rings (92% maximum relaxation; EC50: 2...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28934878/surgical-preparation-for-articular-cartilage-regeneration-in-the-osteoarthritic-knee-joint
#2
Joerg Mika, Thomas O Clanton, Catherine G Ambrose, Raimund W Kinne
PURPOSE: Autologous chondrocyte implantation (ACI) is a treatment option even in early osteoarthritis (OA). Surgical preparation for ACI should avoid penetration of the subchondral bone plate to prevent hemorrhage, fibrin clot formation, and subsequent activation of the inflammatory response. HYPOTHESIS: Current surgical procedures with ring curettes preserve the integrity of the subchondral bone plate, even in patients with OA. METHODS: Subchondral femoral bone plates ( n = 40) of OA knees undergoing total knee arthroplasty were prepared in vivo using standard, non-brute-force debridement for ACI...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28933255/organizational-hierarchy-and-structural-diversity-of-microvascular-pericytes-in-adult-mouse-cortex
#3
Roger I Grant, David A Hartmann, Robert G Underly, Andrée-Anne Berthiaume, Narayan R Bhat, Andy Y Shih
Smooth muscle cells and pericytes, together called mural cells, coordinate many distinct vascular functions. Canonically, smooth muscle cells are ring-shaped and cover arterioles with circumferential processes, whereas pericytes extend thin processes that run longitudinally along capillaries. In between these canonical mural cell types are cells with features of both smooth muscle cells and pericytes. Recent studies suggest that these transitional cells are critical for controlling blood flow to the capillary bed during health and disease, but there remains confusion on how to identify them and where they are located in the brain microvasculature...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28928621/anomalous-origin-of-the-left-brachiocephalic-artery-in-the-right-aortic-arch-is-there-a-method-to-the-madness
#4
Mani Ram Krishna, Ganesh Kumar Gnanappa, Rachel Fitzpatrick, Julian Ayer, David Winlaw
The anomalous origin of the left brachiocephalic artery in a right sided aortic arch is a rare vascular ring which might lead to esophageal compression. The exact embryological origin of this anomaly is still widely debated. We present an infant who presented with esophageal compression symptoms and review the various hypotheses about the embryological origin of this anomaly.
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28927449/beyond-classic-dermoscopic-patterns-of-dermatofibromas-a-prospective-research-study
#5
Awatef Kelati, Nima Aqil, Hanane Baybay, Salim Gallouj, Fatima Zahra Mernissi
BACKGROUND: The usual stereotypical dermoscopic pattern associated with dermatofibromas is a pigment network and central white patch. However, this pattern may be difficult to diagnose in some variant cases. We aimed to describe dermoscopic patterns of dermatofibroma according to its histopathological subtypes, with special emphasis on new and rare dermoscopic features. METHODS: This prospective study, which was conducted between September 2015 and May 2016 in the Department of Dermatology, University Hospital Hassan II, Fez, Morocco, included 100 cases of dermatofibroma confirmed on clinical and histological grounds...
September 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28927252/microangiopathic-hemolytic-anemia-caused-by-a-signet-ring-cell-carcinoma-of-the-intrahepatic-bile-duct
#6
Ramy Younes, Paola Ponzo, Alfredo Marzano
Microangiopathic hemolytic anemia (MAHA) originates from a mechanical injury of red cells, caused by vascular thrombosis or stenosis. Cancer is a cause of MAHA as a consequence of both chemotherapy and disseminated disease itself. Here we describe the case of a 60-year-old man who developed a signet-ring cell carcinoma originated from the intrahepatic bile ducts, complicated by bone marrow metastasis and MAHA.
December 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28926106/oroxyloside-inhibits-angiogenesis-through-suppressing-internalization-of-vegfr2-flk-1-in-endothelial-cells
#7
Kai Zhao, Xiaorui Li, Binyan Lin, Dawei Yang, Yuxin Zhou, Zhiyu Li, Qinglong Guo, Na Lu
Increasing flavonoids have been reported to possess anti-angiogenic effects. Inhibition of angiogenesis plays a critical role in the treatment of cancer, especially in advanced metastatic cancer. In this study, we assessed the effect of Oroxylin A-7-glucuronide (Oroxyloside), a main metabolite of Oroxylin A, on angiogenesis in human endothelial cell-like EA.hy926 cells. Oroxyloside suppressed the migration and tube formation of EA.hy926 cells. Meanwhile, microvessels sprouting from aortic rings and new blood vessels on the chicken chorioallantoic membrane (CAM) were also inhibited...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28924208/chebulinic-acid-inhibits-smooth-muscle-cell-migration-by-suppressing-pdgf-r%C3%AE-phosphorylation-and-inhibiting-matrix-metalloproteinase-2-expression
#8
In-Sung Song, Yu Jeong Jeong, Jung-Hyun Park, Sungbo Shim, Sung-Wuk Jang
Excessive migration of vascular smooth muscle cells (VSMCs) after vascular injury contributes to the development of occlusive vascular disease. Inhibition of VSMC migration is a validated therapeutic modality for occlusive vascular diseases, such as atherosclerosis and restenosis. We investigated the inhibitory effect of chebulinic acid (CBA) on cell migration and matrix metalloproteinase (MMP)-2 activation in platelet-derived growth factor (PDGF)-BB-induced mouse and human VSMCs. CBA significantly inhibited PDGF-BB-induced migration in mouse and human VSMCs, without inducing cell death...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922745/big-brother-uncouples-cell-proliferation-from-elongation-in-the-arabidopsis-primary-root
#9
Pietro Cattaneo, Christian S Hardtke
Plant organ size is sensitive to environmental conditions, but is also limited by hardwired genetic constraints. In Arabidopsis, a few organ size regulators have been identified. Among them, the BIG BROTHER (BB) gene has a prominent role in the determination of flower organ and leaf size. BB loss-of-function mutations result in a prolonged proliferation phase during leaf(-like) organ formation, and consequently larger leaves, petals and sepals. Whether BB has a similar role in root growth is unknown. Here we describe a novel bb allele which carries a P235L point mutation in the BB RING finger domain...
September 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28918858/coronary-ct-angiography-features-of-ruptured-and-high-risk-atherosclerotic-plaques-correlation-with-intra-vascular-ultrasound
#10
Daniel R Obaid, Patrick A Calvert, Adam Brown, Deepa Gopalan, Nick E J West, James H F Rudd, Martin R Bennett
BACKGROUND: Features of ruptured and high-risk plaque have been described on coronary computed tomography angiography (coronary CTA), but not systematically assessed against intravascular ultrasound (IVUS). We examined the ability of coronary CTA to identify IVUS defined ruptured plaque and Virtual Histology Intravascular Ultrasound (VH-IVUS) defined thin-cap fibroatheroma (TCFA). METHODS: Sixty-three patients (32 with acute coronary syndrome and 31 with stable angina) underwent coronary CTA, IVUS and VH-IVUS...
September 5, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28914193/chalcone-derivatives-anti-inflammatory-potential-and-molecular-targets-perspectives
#11
Debarshi Kar Mahapatra, Sanjay Kumar Bharti, Vivek Asati
Chalcone or (E)-1,3-diphenyl-2-propene-1-one scaffold has gained considerable scientific interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety of derivatives and exhibiting a broad range of promising pharmacological activities by modulating several molecular targets. A number of natural and (semi-) synthetic chalcone derivatives have demonstrated admirable anti-inflammatory activity due to their inhibitory potential against various therapeutic targets like cyclooxygenase (COX), lipooxygenase (LOX), interleukins (IL), prostaglandins (PGs), nitric oxide synthase (NOS), leukotriene D4 (LTD4), nuclear factor-κB (NF-κB), intracellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and TLR4/MD-2, etc...
September 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28912106/vascular-activation-of-k-channels-and-na-k-atpase-activity-of-estrogen-deficient-female-rats
#12
Rogério Faustino Ribeiro, Jonaina Fiorim, Vinicius Bermond Marques, Karoline de Sousa Ronconi, Tatiani Botelho, Marcella D Grando, Lusiane M Bendhack, Dalton Valentim Vassallo, Ivanita Stefanon
The goal of the present study was to evaluate vascular potassium channels and Na(+)-K(+)-ATPase activity in estrogen deficient female rats. Female rats that underwent ovariectomy were assigned to receive daily treatment with placebo (OVX) or estrogen replacement (OVX+E2, 1mg/kg, once a week, i.m.). Aortic rings were used to examine the involvement of K(+) channels and Na(+)-K(+)-ATPase in vascular reactivity. Acetylcholine (ACh)-induced relaxation was analyzed in the presence of L-NAME (100μM) and K(+) channels blockers: tetraethylammonium (TEA, 5mM), 4-aminopyridine (4-AP, 5mM), iberiotoxin (IbTX, 30nM), apamin (0...
September 11, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28910435/repeatability-and-reproducibility-of-superficial-macular-retinal-vessel-density-measurements-using-optical-coherence-tomography-angiography-en-face-images
#13
Jianqin Lei, Mary K Durbin, Yue Shi, Akihito Uji, Siva Balasubramanian, Elmira Baghdasaryan, Mayss Al-Sheikh, Srinivas R Sadda
Importance: The repeatability and reproducibility of quantitative metrics from optical coherence tomographic angiography (OCTA) must be assessed before these data can be confidently interpreted in clinical research and practice. Objective: To evaluate the repeatability and reproducibility of OCTA-derived retinal vascular quantitative metrics. Design, Setting and Participants: In this cross-sectional study, 21 healthy volunteers (42 eyes) and 22 patients with retinal disease (22 eyes), including 14 with age-related macular degeneration, 3 with epiretinal membrane, 2 with diabetic retinopathy, 2 with myopic macular degeneration, and 1 with retinal vein occlusion, were enrolled...
September 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28905315/preliminary-studies-of-acute-cadmium-administration-effects-on-the-calcium-activated-potassium-skca-and-bkca-channels-and-na-k-atpase-activity-in-isolated-aortic-rings-of-rats
#14
Dalton V Vassallo, Camila C P Almenara, Gilson Brás Broseghini-Filho, Ariane Calazans Teixeira, David Chaves F da Silva, Jhuli K Angeli, Alessandra S Padilha
Cadmium is an environmental pollutant closely linked with cardiovascular diseases that seems to involve endothelium dysfunction and reduced nitric oxide (NO) bioavailability. Knowing that NO causes dilatation through the activation of potassium channels and Na(+)/K(+)-ATPase, we aimed to determine whether acute cadmium administration (10 μM) alters the participation of K(+) channels, voltage-activated calcium channel, and Na(+)/K(+)-ATPase activity in vascular function of isolated aortic rings of rats. Cadmium did not modify the acetylcholine-induced relaxation...
September 13, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28902610/transient-vasospastic-response-following-the-injection-of-corticosteroid-into-the-hand
#15
Jacob Tulipan, Kevin Lutsky, Pedro Beredjiklian
A sixty-year-old right hand dominant woman with longstanding left basal joint arthritis and right small trigger finger presented for corticosteroid injections to both areas. She had previously received injections with no adverse effects and good relief of symptoms. Following this most recent injection of corticosteroid, she experienced transient ischemia of the left hand and the right long and ring fingers. Corticosteroid injections can rarely cause local vasospasm, even when not inadvertently injected into the vascular system...
May 2017: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/28901725/alamandine-reverses-hyperhomocysteinemia-induced-vascular-dysfunction-via-pka-dependent-mechanisms
#16
Tawar Qaradakhi, Minos Timotheos Matsoukas, Alan Hayes, Emma Rybalka, Martin Caprnda, Kvetoslava Rimarova, Milan Sepsi, Dietrich Büsselberg, Peter Kruzliak, John Matsoukas, Vasso Apostolopoulos, Anthony Zulli
INTRODUCTION: Hyperhomocysteinemia (HHcy) impairs nitric oxide endothelium-dependent vasodilation, consequently leading to atherosclerosis, a risk factor for cardiovascular disease. Novel treatments for HHcy are necessary. AIM: We tested the hypothesis that alamandine, a vasoactive peptide of the renin-angiotensin system (RAS), could reverse HHcy-induced vascular dysfunction through the MrgD receptor, and that this is mediated by the protein kinase A (PKA) pathway...
September 13, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28900851/tributyltin-chloride-disrupts-aortic-vascular-reactivity-and-increases-reactive-oxygen-species-production-in-female-rats
#17
Carolina Falcão Ximenes, Samya Mere Lima Rodrigues, Priscila Lang Podratz, Eduardo Merlo, Julia Fernandez Puñal de Araújo, Lívia Carla Melo Rodrigues, Juliana Barbosa Coitinho, Dalton Valentim Vassallo, Jones Bernardes Graceli, Ivanita Stefanon
Organotin compounds, such as tributyltin (TBT), are environment contaminants that induce bioaccumulation and have potential toxic effects on marine species and mammals. TBT have been banned by the International Maritime Organization in 2003. However, the assessment of butyltin and metal contents in marine sediments has demonstrated high residual levels of TBT in some cases exceeding 7000 ng Sn g(-1). The acceptable daily intake (ADI) level for TBT established by the World Health Organization is 0.5 μg/kg bw/day is based on genotoxicity, reproduction, teratogenicity, immunotoxicity, and mainly neurotoxicity...
September 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28895039/wheezing-in-infancy-an-overview-of-recent-literature
#18
REVIEW
Christine Muglia, John Oppenheimer
PURPOSE OF REVIEW: Wheezing in infancy is a common presentation with many potential causes. In writing this review, we sought to summarize the newest recommendations and testing available for the more common etiologies of wheezing. RECENT FINDINGS: Regarding the diagnosis of asthma, the modified asthma predictive index has recently been established as a useful predictive tool. Non-breath held multidetector CT with 3D volume rendering airway images is also a newer helpful diagnostic tool for tracheomalacia due to ease of use and its 100% positive predictive value...
September 11, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28894642/contrast-based-circular-approximation-for-accurate-and-robust-optic-disc-segmentation-in-retinal-images
#19
Jose Sigut, Omar Nunez, Francisco Fumero, Marta Gonzalez, Rafael Arnay
A new method for automatic optic disc localization and segmentation is presented. The localization procedure combines vascular and brightness information to provide the best estimate of the optic disc center which is the starting point for the segmentation algorithm. A detection rate of 99.58% and 100% was achieved for the Messidor and ONHSD databases, respectively. A simple circular approximation to the optic disc boundary is proposed based on the maximum average contrast between the inner and outer ring of a circle centered on the estimated location...
2017: PeerJ
https://www.readbyqxmd.com/read/28894625/exploratory-studies-of-some-mexican-medicinal-plants-cardiovascular-effects-in-rats-with-and-without-hypertension
#20
Gil Alfonso Magos-Guerrero, Jacinto Santiago-Mejía, Omar F Carrasco
BACKGROUND: Papaveraceae Argemone mexicana L., Burseraceae Bursera simaruba (L.) Sarg., Acanthaceae Justicia spicigera Schltdl. and Selaginellaceae Selaginella lepidophylla (Hook. & Grev.) Spring., have been used in Mexican traditional medicine to treat hypertension. The objective of this study was to further characterize the cardiovascular effects of the methanol extracts of such plants. METHODS: The medicinal plants were collected and taxonomically identified; the methanol extract of each explored plant were administrated to conscious and unconscious male Wistar rats with and without glucose-induced hypertension...
July 2017: Journal of Intercultural Ethnopharmacology
keyword
keyword
14121
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"