keyword
https://read.qxmd.com/read/38496138/arthroscopic-transphyseal-acl-reconstruction-with-lateral-extraarticular-tenodesis-with-unusual-arthroscopic-meniscal-findings-in-a-case-of-an-adolescent-girl-previously-diagnosed-with-amniotic-band-syndrome
#1
Dhruva Angachekar, Abhay Narvekar, Shivam Patel, Shaswat Shetty
Amniotic band syndrome (ABS) constriction rings in the lower limb are common. Despite this, there is insufficient literature on anatomical abnormalities in the knee joints of children with ABS. There is an increasing incidence of paediatric anterior cruciate ligament (ACL) injuries recently. ACL reconstruction in this population has an extra dilemma of sparing the physis to prevent growth disturbances. Treating both these conditions simultaneously is a challenge that is rarely encountered. In our literature review, we found no case such as this...
February 2024: Curēus
https://read.qxmd.com/read/38474378/the-combination-of-vascular-endothelial-growth-factor-a-vegf-a-and-fibroblast-growth-factor-1-fgf1-modified-mrna-improves-wound-healing-in-diabetic-mice-an-ex-vivo-and-in-vivo-investigation
#2
JOURNAL ARTICLE
Sandra Tejedor, Maria Wågberg, Cláudia Correia, Karin Åvall, Mikko Hölttä, Leif Hultin, Michael Lerche, Nigel Davies, Nils Bergenhem, Arjan Snijder, Tom Marlow, Pierre Dönnes, Regina Fritsche-Danielson, Jane Synnergren, Karin Jennbacken, Kenny Hansson
BACKGROUND: Diabetic foot ulcers (DFU) pose a significant health risk in diabetic patients, with insufficient revascularization during wound healing being the primary cause. This study aimed to assess microvessel sprouting and wound healing capabilities using vascular endothelial growth factor (VEGF-A) and a modified fibroblast growth factor (FGF1). METHODS: An ex vivo aortic ring rodent model and an in vivo wound healing model in diabetic mice were employed to evaluate the microvessel sprouting and wound healing capabilities of VEGF-A and a modified FGF1 both as monotherapies and in combination...
February 27, 2024: Cells
https://read.qxmd.com/read/38467893/variations-in-the-evaluation-and-management-of-vascular-rings-a-survey-of-american-clinicians
#3
JOURNAL ARTICLE
Daniel M Pasternack, Achiau Ludomirsky, Reina B Tan, Cynthia Amirtharaj
Vascular rings are arterial malformations that lead to the compression of the trachea and/or esophagus. While "tight" rings often produce symptoms and require surgery, "loose" rings rarely produce symptoms. Given advances in fetal echocardiography, this diagnosis is now more often made prenatally. This poses a new conundrum in the management of asymptomatic patients, leading to practice variation and creating a target for clinical system improvement. Hence, we conducted this survey aiming to demonstrate the practice variation existing in current evaluation and management of these patients...
March 11, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38467357/zeaxanthin-impairs-angiogenesis-and-tumor-growth-of-glioblastoma-an-in-vitro-and-in-vivo-study
#4
JOURNAL ARTICLE
Feifei Lu, Qing Wu, Jiaming Lei, Yanhong Zhou, Yifei Liu, Ni Zhu, You Yu, Li Lin, Meichun Hu
OBJECTIVES: To investigate the therapeutic effects of Zeaxanthin (Zea), one of the oxidized xanthophyll carotenoids belonging to the isoprenoids, on inhibiting the angiogenesis and tumor growth of glioblastoma (GBM) via an in vitro and in vivo study. METHODS: The effects of Zea on the proliferation, adhesion, migration and invasion of human GBM cell lines were detected by cell proliferation assay, cell adhesion assay and Transwell assay. The effect of Zea on angiogenesis was detected by rat aortic ring assay and human umbilical vein endothelial cells (HUVEC) in vitro tube formation assay...
March 9, 2024: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/38467271/boundary-cap-neural-crest-stem-cells-promote-angiogenesis-after-transplantation-to-avulsed-dorsal-roots-in-mice-and-induce-migration-of-endothelial-cells-in-3d-printed-scaffolds
#5
JOURNAL ARTICLE
Carl Trolle, Yilin Han, Shivaprakash Jagalur Mutt, Gustaf Christoffersson, Elena N Kozlova
Dorsal root avulsion injuries lead to loss of sensation and to reorganization of blood vessels (BVs) in the injured area. The inability of injured sensory axons to re-enter the spinal cord results in permanent loss of sensation, and often also leads to the development of neuropathic pain. Approaches that restore connection between peripheral sensory axons and their CNS targets are thus urgently need. Previous research has shown that sensory axons from peripherally grafted human sensory neurons are able to enter the spinal cord by growing along BVs which penetrate the CNS from the spinal cord surface...
March 9, 2024: Neuroscience Letters
https://read.qxmd.com/read/38462836/proof-of-concept-development-of-a-mitral-annuloplasty-ring-with-crosshatch-net
#6
JOURNAL ARTICLE
Benjamin D Seadler, David L Joyce, James Zelten, Kevin Sweeney, Taylor Wisgerhof, Zoey Slettehaugh, Y William Yuan, Brandon Tefft, Paul J Pearson
OBJECTIVE: Here we report our preclinical, proof-of-concept testing to assess the ability of a novel device to correct mitral regurgitation. The Milwaukee Heart device aims to enable any cardiac surgeon to perform high-quality mitral valve repair using a standard annuloplasty ring with a crosshatch of microporous, monofilament suture. METHODS: Hemodynamic, echocardiographic, and videographic data were collected at baseline, following induction of mitral regurgitation, and after repair using porcine hearts in an ex vivo biosimulator model...
March 10, 2024: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://read.qxmd.com/read/38462372/-clinical-observation-of-the-intraocular-distribution-characteristics-of-indocyanine-green-after-epiretinal-membrane-peeling-using-a-fluorescence-detection-system-developed-in-python
#7
JOURNAL ARTICLE
Y Zhang, K R Zhang, S Gao, M X Zhang
Objective: To utilize a Python-based fluorescence area detection system to observe and quantitatively analyze the intraocular distribution characteristics and metabolic patterns of Indocyanine Green (ICG) following epiretinal membrane peeling. Methods: A prospective case series study was conducted on patients with idiopathic epiretinal membrane undergoing vitrectomy at West China Hospital of Sichuan University from March 2019 to March 2021. ICG staining was applied during surgery for peeling the epiretinal membrane and internal limiting membrane...
March 11, 2024: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://read.qxmd.com/read/38460450/antiangiogenic-properties-of-bthmp-a-p-i-metalloproteinase-from-bothrops-moojeni-snake-venom-by-vegf-pathway-in-endothelial-cells
#8
JOURNAL ARTICLE
Vinícius Queiroz Oliveira, Luísa Carregosa Santos, Samuel Cota Teixeira, Thiago Macedo Lopes Correia, Leonardo Oliveira Silva Bastos Andrade, Sarah Natalie Cirilo Gimenes, Mônica Colombini, Lucas Miranda Marques, Eliécer Jiménez-Charris, Luciana Aparecida Freitas-de-Sousa, Marcelo José Barbosa Silva, Amélia Cristina Mendes de Magalhães Gusmão, Eloisa Amália Vieira Ferro, Patricia Bianca Clissa, Veridiana de Melo Rodrigues, Daiana Silva Lopes
Angiogenesis is a process that is controlled by a delicate combination of proangiogenic and antiangiogenic molecules and can be disrupted in various illnesses, including cancer. Non-cancerous diseases can also have an abnormal or insufficient vascular growth, inflammation and hypoxia, which exacerbate angiogenesis. These conditions include atherosclerosis, psoriasis, endometriosis, asthma, obesity and AIDS. Based on that, the present work assessed the in vitro and ex vivo antiangiogenic properties stemming from BthMP, a P-I metalloproteinase from Bothrops moojeni snake venom, via the VEGF pathway...
March 5, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38459848/-right-middle-lung-cancer-with-double-aortic-arch-report-of-a-case
#9
JOURNAL ARTICLE
Daisuke Ito, Shin Shomura, Hitoshi Suzuki
Double aortic arch is an embryological abnormality of the aortic arch forming a vascular ring. It has been noted that the right recurrent nerve travels differently in patients with a duplicated aortic arch and may be in close proximity to the area of superior mediastinal lymph node dissection in lung cancer. We report a surgical case of a patient with right middle lung cancer associated with a duplicated aortic arch. A 64-year-old man was referred to our hospital because of a nodular shadow in the right lung field noted on chest X-ray during a medical checkup...
January 2024: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://read.qxmd.com/read/38459633/neonatal-nasal-necrosis-case-series-and-brief-review
#10
Jamie L Karch, David Grand, Ariana G Diaz, Leah Belazarian, Julianne A Mann
There is limited information available on pressure-related neonatal nasal injuries. We present three neonates born with erythema and purpura of the nasal tip that subsequently ulcerated, then evolved into a thick eschar. Each healed well with conservative management but left behind significant scarring. The sharp demarcation and location of the lesions were suggestive of hypoxic tissue damage akin to halo scalp ring alopecia. Further investigation is necessary to elucidate the etiology and optimal management of this condition...
March 8, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38449376/structural-characterization-and-rat-aortic-vascular-reactivity-of-bradykinin-potentiating-peptides-bpps-from-the-snake-venom-of-bothrops-moojeni-from-delta-do-parna%C3%A3-ba-region-brazil
#11
JOURNAL ARTICLE
Samuel R Costa, Andreanne G Vasconcelos, José Otávio C S Almeida, Daniel D R Arcanjo, Anderson Dematei, Eder A Barbosa, Pedro Costa Silva, Thiago Nascimento, Lucianna H Santos, Peter Eaton, José Roberto S de A Leite, Guilherme D Brand
Snake venoms contain various bradykinin-potentiating peptides (BPPs). First studied for their vasorelaxant properties due to angiotensin converting enzyme (ACE) inhibition, these molecules present a range of binding partners, among them the argininosuccinate synthase (AsS) enzyme. This has renewed interest in their characterization from biological sources and the evaluation of their pharmacological activities. In the present work, the low molecular weight fraction of Bothrops moojeni venom was obtained and BPPs were characterized by mass spectrometry...
March 6, 2024: Journal of Natural Products
https://read.qxmd.com/read/38447883/epac-inhibitor-suppresses-angiogenesis-and-tumor-growth-of-triple-negative-breast-cancer
#12
JOURNAL ARTICLE
Zishuo Li, Qiao Liu, Yuhao Cai, Na Ye, Zinan He, Yuying Yao, Yi Ding, Pingyuan Wang, Cuiling Qi, Lingyun Zheng, Lijing Wang, Jia Zhou, Qian-Qian Zhang
AIMS: Exchange protein directly activated by cAMP 1 (EPAC1), a major isoform of guanine nucleotide exchange factors, is highly expressed in vascular endothelia cells and regulates angiogenesis in the retina. High intratumor microvascular densities (MVD) resulting from angiogenesis is responsible for breast cancer development. Downregulation of EPAC1 in tumor cell reduces triple-negative breast cancer (TNBC)-induced angiogenesis. However, whether Epac1 expressed in vascular endothelial cells contributes to angiogenesis and tumor development of TNBC remains elusive...
March 4, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38437796/shwachman-diamond-syndrome-associated-with-rod-cone-dystrophy
#13
JOURNAL ARTICLE
Jingwen Zhang, Thales A C de Guimaraes, Dorothy Thompson, Michel Michaelides
PURPOSE: To report a patient with Shwachman-Diamond syndrome and concomitant rod-cone dystrophy who underwent bone marrow transplantation. METHODS: Retrospective single case report. RESULTS: A female patient with Shwachman-Diamond syndrome was referred to a tertiary hospital to investigate possible pigmentary retinopathy at the age of 16. She described poor night vision and was found to have reduced visual acuity (6/20 right, 6/38 left). Over the ten-year follow-up period, her visual acuity remained relatively stable with no new visual symptoms...
March 4, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38428573/vascular-dysfunction-programmed-in-male-rats-by-topiramate-during-peripubertal-period
#14
JOURNAL ARTICLE
Kawane F Moura, Deborah Gomes da Silva, Camila Borecki Vidigal, Gabriel Smolak Sobieski E Silva, Ingrid Caroline Pinto, Andréa Name Colado Simão, Bruno V D Marques, Fábio Goulart de Andrade, Rúbia Casagrande, Daniela C C Gerardin, Eliana H Akamine, Maria do Carmo P Franco, Graziela S Ceravolo
AIM: The present study evaluated whether topiramate (TPM) treatment during the peripubertal period affects vascular parameters of male rats and whether oxidative stress plays a role in these changes. MAIN METHODS: Rats were treated with TPM (41 mg/kg/day, gavage) or vehicle (CTR group) from the postnatal day (PND) 28 to 50. At PND 51 and 120 the rats were evaluated for: thoracic aorta reactivity to phenylephrine, in the presence (Endo+) or absence of endothelium (Endo-), acetylcholine and sodium nitroprusside (SNP), aortic thickness and endothelial nitric oxide synthase (eNOS) expression...
February 28, 2024: Life Sciences
https://read.qxmd.com/read/38422276/morphometry-topography-and-arterial-supply-of-the-thyroid-gland-in-rhesus-monkeys-macaca-mulatta-zimmermann-1780
#15
JOURNAL ARTICLE
A V Stocco, R Medeiros-do-Nascimento, C T Messias, C A Santos-Sousa, P Souza-Junior, A Pissinatti, M Abidu-Figueiredo
The purpose of this research was to investigate the measures, topography, and vascularization of the thyroid gland in Macaca mulatta, a non-human primate. The study involved the dissection of ten male adult cadavers of Macaca mulatta. The length, width, and thickness of the right lobe of the thyroid were 2.552 ± 0.341, 1.019 ± 0.137, and 0.729 ± 0.137 cm. These measures in the left thyroid lobe were 2.406 ± 0.299, 1.013. ± 0.087, and 0.769 ± 0.083 cm. The study found no significant differences in the measures of the left and right lobes of the thyroid gland in rhesus monkeys...
2024: Brazilian Journal of Biology
https://read.qxmd.com/read/38418756/functional-deterioration-of-vascular-mitochondrial-and-glycolytic-capacity-in-the-aortic-rings-of-aged-mice
#16
JOURNAL ARTICLE
Agnieszka Karaś, Anna Bar, Kanchana Pandian, Agnieszka Jasztal, Zuzanna Kuryłowicz, Barbara Kutryb-Zając, Elżbieta Buczek, Stefano Rocchetti, Tasnim Mohaissen, Agata Jędrzejewska, Amy C Harms, Patrycja Kaczara, Stefan Chłopicki
Vascular ageing is associated with increased arterial stiffness and cardiovascular mortality that might be linked to altered vascular energy metabolism. The aim of this study was to establish a Seahorse XFe96 Analyzer-based methodology for the reliable, functional assessment of mitochondrial respiration and glycolysis in single murine aortic rings and to validate this functional assay by characterising alterations in vascular energy metabolism in aged mice. Healthy young and old C57BL/6 mice were used for the analyses...
February 28, 2024: GeroScience
https://read.qxmd.com/read/38417578/paraspeckle-protein-nono-attenuates-vascular-calcification-by-inhibiting-bone-morphogenetic-protein-2-transcription
#17
JOURNAL ARTICLE
Yue Lu, Linlin Meng, Ruiqing Ren, Xinlu Wang, Wenhai Sui, Fei Xue, Lin Xie, Ang Chen, Yuxia Zhao, Jianmin Yang, Wencheng Zhang, Xiao Yu, Bo Xi, Feng Xu, Meng Zhang, Yun Zhang, Cheng Zhang
Vascular calcification is a pathological process commonly associated with atherosclerosis, chronic kidney disease, and diabetes. Paraspeckle protein NONO is a multifunctional RNA/DNA binding protein involved in many nuclear biological processes but its role in vascular calcification remains unclear. Here, we observed that NONO expression was decreased in calcified arteries of mice and patients with CKD. We generated smooth muscle-specific NONO-knockout mice and established three different mouse models of vascular calcification by means of 5/6 nephrectomy, adenine diet to induce chronic kidney failure, or vitamin D injection...
February 26, 2024: Kidney International
https://read.qxmd.com/read/38414070/comparison-of-a-coupling-system-and-the-suture-method-in-end-to-side-microvascular-anastomosis-in-head-and-neck-reconstruction
#18
Seong Ae Kim, Junnyeon Kim, Chae Rim Lee, Deuk Young Oh, Young-Joon Jun, Suk-Ho Moon
BACKGROUND: Use of coupling devices in microvascular anastomosis continues to increase, but it is not yet actively used in end-to-side (ETS) anastomosis because there is no standard method. Therefore, we propose an easy and time-saving ETS micro-anastomosis method using coupling devices in head and neck reconstruction and compare it with the conventional suture method. MATERIALS AND METHODS: We retrospectively reviewed 30 consecutive cases (43 anastomoses) of ETS anastomosis in head and neck reconstruction from 2018 to 2022...
March 2024: Microsurgery
https://read.qxmd.com/read/38412078/an-implantable-magnetic-drive-mechanism-for-non-invasive-arteriovenous-conduit-blood-flow-control
#19
JOURNAL ARTICLE
Nicholas A White, Sander L van der Kroft, Koen E A van der Bogt, Timo J C Oude Vrielink, Christian Camenzuli, Jean Calleja-Agius, Juan A Sanchez-Margallo, Francisco M Sanchez-Margallo, Huybert J F van de Stadt, Jenny Dankelman, Joris I Rotmans, Tim Horeman
OBJECTIVE: Hemodialysis patients usually receive an arteriovenous fistula (AVF) in the arm as vascular access conduit to allow dialysis 2-3 times a week. This AVF introduces the high flow necessary for dialysis, but over time the ever-present supraphysiological flow is the leading cause of complications. This study aims to develop an implantable device able to non-invasively remove the high flow outside dialysis sessions. METHODS: The developed prototype features a magnetic ring allowing external coupling and torque transmission to non-invasively control an AVF valve...
February 27, 2024: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/38407000/extra-anatomic-bypass-procedures-for-severe-aortoiliac-occlusive-disease-a-cohort-study
#20
JOURNAL ARTICLE
George Galyfos, Georgios Charalampopoulos, Alexandros Chamzin, Alexandra Triantafillou, Victoria Michalopoulou, Nikolaos Intzes, Despina Kimpizi, Konstantinos Zarmakoupis, Frangiska Sigala, Konstantinos Filis
OBJECTIVES: Extra-anatomic bypass (ExAB) grafting has been questioned due its inferior durability compared to anatomic bypass for aortoiliac occlusive disease (AIOD). This study aims to present early and late outcomes of patients treated with ExAB as well as to evaluate potential prognostic factors. METHODS: This is a retrospective cohort study presenting a series of patients treated with ExAB for AIOD. All patients were treated between 2005 and 2022 within the Vascular Surgery Unit of a University Surgery Clinic...
February 26, 2024: Vascular
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