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https://www.readbyqxmd.com/read/29788974/eicosapentaenoic-acid-ethyl-ester-improves-endothelial-dysfunction-in-type-2-diabetic-mice
#1
Yasuhiro Takenouchi, Kazuo Ohtake, Koji Nobe, Keizo Kasono
BACKGROUND: Eicosapentaenoic acid (EPA) is thought to have many beneficial effects, such as anti-atherosclerogenic and anti-inflammatory properties. However, few studies have reported its effects of endothelial dysfunction in diabetes and its direct effects on the aorta. Here, we investigated the effects of EPA treatment on impaired endothelium-dependent relaxation of the aorta in KKAy mice, a model of type 2 diabetes. METHODS: Male KKAy mice were fed a high-fat (HF) diet for 8 weeks to induce diabetes, after which they were divided into two groups...
May 22, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29787262/discovery-of-novel-pazopanib-based-hdac-and-vegfr-dual-inhibitors-targeting-cancer-epigenetics-and-angiogenesis-simultaneously
#2
Jie Zang, Xuewu Liang, Yongxue Huang, Yuping Jia, Xiaoyang Li, Wenfang Xu, C James Chou, Yingjie Zhang
Herein a novel series of pazopanib hybrids as polypharmacological antitumor agents were developed based on the crosstalk between histone deacetylases (HDACs) and vascular endothelial growth factor (VEGF) pathway. Among them, one ortho-aminoanilide 6d and one hydroxamic acid 13f exhibited considerable total HDACs and VEGFR-2 inhibitory activities. The HDAC inhibitory activities endowed 6d and 13f with potent antiproliferative activities, which was not observed in the approved VEGFR inhibitor pazopanib. Compounds 6d and 13f possessed comparable HDAC isoform selectivity profiles to the clinical class I HDAC inhibitor MS-275 and the approved pan-HDAC inhibitor SAHA, respectively...
May 22, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29782517/importance-of-software-version-for-measurement-of-arterial-stiffness-arteriograph-as-an-example
#3
Margareta Ring, Maria J Eriksson, Gunnar Nyberg, Kenneth Caidahl
BACKGROUND: Current guidelines recommend the measurement of arterial stiffness in terms of aortic pulse wave velocity (PWV) as an important cardio-vascular risk marker. Both aortic PWV and the aortic augmentation index (AIxao) can be measured using different techniques, e.g., the Arteriograph and SphygmoCor. A new version of the software for the Arteriograph (v. 3.0.0.1, TensioMed, Budapest, Hungary; Arteriograph II) is now available. We wanted to determine whether this improved software differs from the previous version (Arteriograph v...
2018: PloS One
https://www.readbyqxmd.com/read/29765640/vascularization-of-the-trachea-in-the-bottlenose-dolphin-comparison-with-bovine-and-evidence-for-evolutionary-adaptations-to-diving
#4
Cristina Ballarin, Paola Bagnoli, Antonella Peruffo, Bruno Cozzi
The rigid structure of the mammalian trachea is functional to maintain constant patency and airflow during breathing, but no gas exchange takes place through its walls. The structure of the organ in dolphins shows increased rigidity of the tracheal cartilaginous rings and the presence of vascular lacunae in the submucosa. However, no actual comparison was ever made between the size and capacity of the vascular lacunae of the dolphin trachea and the potentially homologous structures of terrestrial mammals. In the present study, the extension of the lacunae has been compared between the bottlenose dolphin and the bovine, a closely related terrestrial Cetartiodactyla...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29754503/hesperidin-suppresses-renin-angiotensin-system-mediated-nox2-over-expression-and-sympathoexcitation-in-2k-1c-hypertensive-rats
#5
Chutamas Wunpathe, Prapassorn Potue, Putcharawipa Maneesai, Sarawoot Bunbupha, Parichat Prachaney, Upa Kukongviriyapan, Veerapol Kukongviriyapan, Poungrat Pakdeechote
Hesperidin, a flavonoid derived from citrus fruits, possesses several beneficial effects including anti-oxidation and anti-inflammation. The aim of this study was to investigate the effects of hesperidin on the renin-angiotensin system (RAS) cascade that mediated oxidative stress and sympathoexcitation in two-kidney, one-clipped (2K-1C) hypertensive rats. 2K-1C hypertension was induced in male Sprague-Dawley rats. Hypertensive rats were treated with hesperidin at 20[Formula: see text]mg/kg or 40[Formula: see text]mg/kg or losartan at 10[Formula: see text]mg/kg beginning at three weeks after surgery and then continued for four weeks ([Formula: see text]/group)...
May 13, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29753230/nebivolol-prevents-vascular-oxidative-stress-and-hypertension-in-rats-chronically-treated-with-ethanol
#6
Gabriel T do Vale, Janaina A Simplicio, Natália A Gonzaga, Rodrigo Yokota, Amanda A Ribeiro, Dulce E Casarini, Bruno S de Martinis, Carlos R Tirapelli
BACKGROUND AND AIMS: Chronic ethanol consumption is associated with hypertension and atherosclerosis. Vascular oxidative stress is described as an important mechanism whereby ethanol predisposes to atherosclerosis. We hypothesized that nebivolol would prevent ethanol-induced hypertension and vascular oxidative stress. METHODS: Male Wistar rats were treated with ethanol 20% (vol./vol.) or nebivolol (10 mg/kg/day, p. o., gavage), a selective β1 -adrenergic receptor antagonist...
April 30, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29752535/tissue-accumulation-patterns-and-concentrations-of-potassium-phosphorus-and-carboxyfluorescein-translocated-from-pine-seed-to-the-root
#7
Thomas C Pesacreta, Karl H Hasenstein
Potassium (K), phosphorous (P), and carboxyfluorescein (CF) accumulate in functionally distinct tissues within the pine seedling root cortex. Seedlings of Pinus pinea translocate exogenous CF and endogenous K and P from the female gametophyte/cotyledons to the growing radicle. Following unloading in the root tip, these materials accumulate in characteristic spatial patterns. Transverse sections of root tips show high levels of P in a circular ring of several layers of inner cortical cells. K and CF are minimal in the high P tissue...
May 11, 2018: Planta
https://www.readbyqxmd.com/read/29752070/rnf213-p-r4810k-polymorphism-and-the-risk-of-moyamoya-disease-intracranial-major-artery-stenosis-occlusion-and-quasi-moyamoya-disease-a-meta-analysis
#8
Yue Wang, Michael Mambiya, Qian Li, Luping Yang, He Jia, Yibo Han, Wanyang Liu
BACKGROUND: Accumulating studies have reported that there is an association between the Ring finger protein 213 (RNF213) p.R4810K (rs112735431, c.14576G>A) single nucleotide polymorphism and the predisposition of moyamoya disease (MMD), intracranial major artery stenosis/occlusion (ICASO), quasi-moyamoya disease (quasi-MMD), and other vascular diseases. However, to this day, analyses about this association have remained scarce in the literature. We attempted to conduct a meta-analysis to systematically summarize and clarify the issue...
May 8, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29741931/arginase-up-regulation-and-enos-uncoupling-contribute-to-impaired-endothelium-dependent-vasodilation-in-a-rat-model-of-intrauterine-growth-restriction
#9
Isabelle Grandvuillemin, Christophe Buffat, Farid Boubred, Edouard Lamy, Julien Fromonot, Philippe Charpiot, Stephanie Simoncini, Florence Sabatier, Françoise Dignat-George, Anne-Christine Peyter, Umberto Simeoni, Catherine Yzydorczyk
Individuals born after intrauterine growth restriction (IUGR) are at increased risk of developing cardiovascular diseases in adulthood, notably hypertension (HTN). Alterations in the vascular system, particularly impaired endothelium-dependent vasodilation, may play an important role in long-term effects of IUGR. Whether such vascular dysfunction precedes HTN has not been fully established in individuals born after IUGR. Moreover, the intimate mechanisms of altered endothelium-dependent vasodilation remain incompletely elucidated...
May 9, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29736923/reconstruction-of-complex-tissue-defect-of-forearm-with-a-chimeric-flap-composed-of-a-sural-neurocutaneous-flap-and-a-vascularized-fibular-graft-a-case-report
#10
Chunyang Wang, Jia Xu, Gen Wen, Yimin Chai
One-stage reconstruction of composite bone and soft-tissue defects in the forearm remains a tough challenge. Here, we present a case of reconstruction of complex tissue defect at forearm with a chimeric flap consisting of a sural neurocutaneous flap and a fibular graft. A 61-year-old man suffered from a machine crush injury in his left forearm, resulting in a complex tissue defect including extensive dorsomedial soft-tissue, digit extensor muscles of 2-4 fingers, the muscle flexor carpi ulnaris, the ulna bone with 5...
May 7, 2018: Microsurgery
https://www.readbyqxmd.com/read/29731445/synthesis-characterization-and-antihypertensive-activity-of-2-phenyl-substituted-benzimidazoles
#11
Muhammad Tariq Khan, Muhammad Tahir Razi, Syed Umer Jan, Muhammad Mukhtiar, Rahman Gul, - IzharUllah, Abid Hussain, Asif Mehmood Hashmi, Muhammad Taufiq Ahmad, Nisar Ahmed Shahwani, Imran Rabbani
Hypertension is one of cardiovascular disease that is not sufficiently prevented and controlled at both hospital and community levels. Hypertension resulted in significant morbidity and mortality. The benz-imidazole ring is very important pharmacophore in modern drug discovery. The substituted benzimidazoles are the important for medicinal research. Researchers have reported that substituted Benzimidazoles are the structural isosteres of nucleotides, and easily allow them to interact with the different biopolymers, possess pharmacological activity especially antihypertensive activity...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29725515/a-limb-threatening-long-arterial-dissection-caused-by-humerus-neck-fracture-a-case-report
#12
R Kurnaz, M Ikizler, M Ozbayburtlu, T Gunes
Proximal humerus fracture is a common arm trauma and rarely occurs with vascular injury which however is a serious complication. In this case report, we present a long segment dissection of the axillary and brachial arteries as a rare complication due to fragmented proximal humerus fracture and shoulder dislocation. An 80-year old female patient was seen at the emergency department. Radiograph examination has revealed a fragmented proximal humerus fracture besides dislocation of the head of humerus towards the axillary area...
March 2018: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29724157/assembly-of-tissue-engineered-blood-vessels-with-spatially-controlled-heterogeneities
#13
Hannah A Strobel, Tracy Hookway, Marco Piola, Gianfranco Beniamino Fiore, Monica Soncini, Eben Alsberg, Marsha Rolle
Tissue-engineered human blood vessels may enable in vitro disease modeling and drug screening to accelerate advances in vascular medicine. Existing methods for tissue engineered blood vessel (TEBV) fabrication create homogenous tubes not conducive to modeling the focal pathologies characteristic of vascular disease. We developed a system for generating self-assembled human smooth muscle cell ring-units, which were fused together into TEBVs. The goal of this study was to assess the feasibility of modular assembly and fusion of ring building units to fabricate spatially-controlled, heterogeneous tissue tubes...
May 4, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29723537/ring-finger-protein-10-prevents-neointimal-hyperplasia-by-promoting-apoptosis-in-vitro-and-in-vivo
#14
Guiquan Yu, Jing Chen, Siyu Li, Peng Pu, Wei Huang, Yongpeng Zhao, Xin Peng, Ruiyu Wang, Han Lei
AIMS: Vascular restenosis and neointimal hyperplasia are enhanced in metabolic syndrome (MetS). Vascular smooth muscle cell (VSMC) proliferation is a key step during restenosis and is suppressed by RING finger protein 10 (RNF10). However, the effect of RNF10 on neointimal hyperplasia is unknown. In the present study, we explored whether RNF10 over-expression prevents neointimal hyperplasia in a MetS rat model and in cultured VSMCs exposed to high glucose. MAIN METHODS: An adenovirus encoding RNF10 (Ad-RNF10) or control green fluorescent protein (Ad-GFP) was delivered to balloon-injured carotid arteries in MetS rats and cultured rat VSMCs exposed to high glucose...
April 30, 2018: Life Sciences
https://www.readbyqxmd.com/read/29712741/cystathionine-%C3%AE-lyase-produced-hydrogen-sulfide-controls-endothelial-no-bioavailability-and-blood-pressure
#15
István András Szijártó, Lajos Markó, Milos R Filipovic, Jan Lj Miljkovic, Christoph Tabeling, Dmitry Tsvetkov, Ning Wang, Luiza A Rabelo, Martin Witzenrath, André Diedrich, Jens Tank, Noriyuki Akahoshi, Shotaro Kamata, Isao Ishii, Maik Gollasch
Hydrogen sulfide (H2 S) and NO are important gasotransmitters, but how endogenous H2 S affects the circulatory system has remained incompletely understood. Here, we show that CTH or CSE (cystathionine γ-lyase)-produced H2 S scavenges vascular NO and controls its endogenous levels in peripheral arteries, which contribute to blood pressure regulation. Furthermore, eNOS (endothelial NO synthase) and phospho-eNOS protein levels were unaffected, but levels of nitroxyl were low in CTH-deficient arteries, demonstrating reduced direct chemical interaction between H2 S and NO...
April 30, 2018: Hypertension
https://www.readbyqxmd.com/read/29709439/vasodilator-effects-and-putative-guanylyl-cyclase-stimulation-by-2-nitro-1-phenylethanone-and-2-nitro-2-phenyl-propane-1-3-diol-on-rat-aorta
#16
Thiago Brasileiro de Vasconcelos, Helder Veras Ribeiro Filho, Saad Lahlou, José Geraldo de Carvalho Pereira, Paulo Sérgio Lopes de Oliveira, Pedro Jorge Caldas Magalhães
Compounds containing a nitro group may reveal vasodilator properties. Several nitro compounds have a NO2 group in a short aliphatic chain connected to an aromatic group. In this study, we evaluated in rat aorta the effects of two nitro compounds, with emphasis on a putative recruitment of a soluble guanylate cyclase (sGC) pathway to induce vasodilation. Isolated aortic rings were obtained from male Wistar rats to compare the effects induced by 2-nitro-1-phenylethanone (NPeth) or 2-nitro-2-phenyl-propane-1,3-diol (NPprop)...
April 27, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29707746/chronic-cadmium-exposure-accelerates-the-development-of-atherosclerosis-and-induces-vascular-dysfunction-in-the-aorta-of-apoe-mice
#17
T F Oliveira, P R Batista, M A Leal, B P Campagnaro, B V Nogueira, D V Vassallo, S S Meyrelles, Alessandra Simão Padilha
Cadmium exposure is related to cardiovascular diseases, including hypertension, atherosclerosis, increased oxidative stress, endothelial dysfunction, and specific biochemical changes induced by this metal. Thus, we aimed to investigate whether cadmium exposure induces endothelial dysfunction, accelerates atherosclerotic plaque formation in the aorta, and enhances oxidative stress in apolipoprotein E knockout (ApoE-/- ) mice. Experiments were performed in 14-week-old male wild-type and ApoE-/- mice. ApoE-/- mice received cadmium (CdCl2 100 mg/L in drinking water for 28 days) or vehicle (distilled water)...
April 29, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29701396/takayasus-s-aortitis-induced-ascending-aorta-dissection
#18
Bruno Fernandes, Joana Saraiva, Lina Carvalho
INTRODUCTION: Takayasu aortitis is a well known yet rare form of large vessel vasculitis. Also known as pulseless disease, occlusive thromboaortopathy, and Martorell syndrome, is a chronic inflammatory aortitis. Vessel inflammation leads to wall thickening, fibrosis, stenosis, and thrombus formation. METHODS: A 64-year-old woman was referred to emergency for lack of pulse in the upper and lower limbs and changes in heart rate. AngioRMN revealed dissection of the ascending aorta while in PET, intense uptake of FDG-F18 involving ascending, crossa, descending thoracic and abdominal segments of the aorta, was evident urgent surgical correction occurred...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29695773/stromal-interaction-molecule-1-modulates-blood-pressure-via-no-production-in-vascular-endothelial-cells
#19
Mitsuhiro Nishimoto, Risuke Mizuno, Toshiro Fujita, Masashi Isshiki
In vascular endothelial cells, store-operated calcium entry (SOCE) activates endothelial NO synthase (eNOS) and regulates nitric oxide (NO) production as well as flow-dependent mechanical stimuli. Stromal interaction molecule 1, or STIM1, was recently identified to be essential for SOCE, acting as a calcium sensor for intracellular calcium stores. However, how STIM1 affects endothelial function and blood pressure (BP) remains unclear. We generated STIM1 fl/fl mice and vascular endothelial cell-specific STIM1 knockout mice using the Cre-loxP system, and conducted experiments using these mice to clarify the physiological role of STIM1 in vascular endothelial function and BP as follows: (1) SOCE was analyzed in isolated aortic endothelial cells by calcium add-back with fluorescent Ca2+ indicators...
April 25, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29694949/overexpression-of-annexin-a2-receptor-inhibits-neovascularization-via-the-promotion-of-kr%C3%A3-ppel-like-transcription-factor-2
#20
Ting Guo, Hongyuan Song, Zichang Zhao, Zhongtian Qi, Shihong Zhao
BACKGROUND/AIMS: Annexin A2 receptor (AX2R) can mediate annexin A2 signalling and induce apoptosis in a variety of cells, but its role in neovascularization (NV) remains unclear. Krüppel-like transcription factor 2 (KLF2) is known to be expressed in a range of cell types and to participate in a number of processes during development and disease, such as endothelial homeostasis, vasoregulation and vascular growth/remodelling. The aim of our study was to investigate the role of AX2R in NV and the plausible molecular mechanism...
April 24, 2018: Cellular Physiology and Biochemistry
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