keyword
MENU ▼
Read by QxMD icon Read
search

Vascular ring

keyword
https://www.readbyqxmd.com/read/29333385/kaempferol-inhibits-angiogenesis-by-suppressing-hif-1%C3%AE-and-vegfr2-activation-via-erk-p38-mapk-and-pi3k-akt-mtor-signaling-pathways-in-endothelial-cells
#1
Gi Dae Kim
Kaempferol has been shown to inhibit vascular formation in endothelial cells. However, the underlying mechanisms are not fully understood. In the present study, we evaluated whether kaempferol exerts antiangiogenic effects by targeting extracellular signal-regulated kinase (ERK)/p38 mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathways in endothelial cells. Endothelial cells were treated with various concentrations of kaempferol for 24 h...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29331788/curcumin-inhibits-cardiac-hypertrophy-and-improves-cardiovascular-function-via-enhanced-na-ca2-exchanger-expression-after-transverse-abdominal-aortic-constriction-in-rats
#2
Xiao-Jie Bai, Jun-Tao Hao, Jin Wang, Wei-Fang Zhang, Cai-Ping Yan, Jia-Hui Zhao, Zhi-Qing Zhao
BACKGROUND: This study tested the hypothesis that inhibition of cardiac hypertrophy and preservation of cardiac/endothelial function by the natural yellow pigment curcumin are associated with upregulated expression of Na+/Ca2+ exchanger (NCX) after transverse aortic constriction (TAC). METHODS: Male Wistar rats were subjected to TAC for 10 weeks and curcumin (50 mg/kg/day) was fed by gastric gavage during TAC. Expression of NCX and endothelial nitric oxide synthase (eNOS) was analyzed by Western blot and immunohistochemistry...
July 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29326427/severe-steatosis-induces-portal-hypertension-by-systemic-arterial-hyporeactivity-and-hepatic-vasoconstrictor-hyperreactivity-in-rats
#3
Denise Van der Graaff, Wilhelmus J Kwanten, Filip J Couturier, Jesse S Govaerts, Wim Verlinden, Isabel Brosius, Michiel D'Hondt, Ann Driessen, Benedicte Y De Winter, Joris G De Man, Peter P Michielsen, Sven M Francque
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease. The presence of portal hypertension has been demonstrated in NAFLD prior to development of inflammation or fibrosis, and is a result of extrahepatic and intrahepatic factors, principally driven by vascular dysfunction. An increased intrahepatic vascular resistance potentially contributes to progression of NAFLD via intralobular hypoxia. However, the exact mechanisms underlying vascular dysfunction in NAFLD remain unknown...
January 11, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29325034/ghrelin-preserves-ischemia-induced-vasodilation-of-male-rat-coronary-vessels-following-beta-adrenergic-receptor-blockade
#4
James T Pearson, Nicola Collie, Regis R Lamberts, Tadakatsu Inagaki, Misa Yoshimoto, Keiji Umetani, Philip Davis, Gerard Wilkins, Pete P Jones, Mikiyasu Shirai, Daryl O Schwenke
Acute myocardial infarction (MI) triggers an adverse increase in cardiac sympathetic nerve activity (SNA). While β-adrenergic receptor (β-AR)-blockers are routinely used for the management of MI, they may also counter β-AR-mediated vasodilation of coronary vessels. We have reported that ghrelin prevents sympathetic activation following MI. Whether ghrelin modulates coronary vascular tone following MI, either through the modulation of SNA, or directly as a vasoactive mediator, has never been addressed.We utilized synchrotron microangiography to image coronary perfusion and vessel internal diameter (ID) in anesthetized Sprague Dawley rats before, and then again 30 mins after induction of an MI (left coronary artery ligation)...
January 9, 2018: Endocrinology
https://www.readbyqxmd.com/read/29317256/nandrolone-combined-with-strenuous-resistance-training-reduces-vascular-nitric-oxide-bioavailability-and-impairs-endothelium-dependent-vasodilation
#5
Vinicius Guzzoni, Tatiana Sousa Cunha, Vander José das Neves, Larissa Briet, Rafaela Costa, Maria José Costa Sampaio Moura, Vanessa Oliveira, Maria do Carmo Pinho Franco, Pedro Duarte Novaes, Fernanda Klein Marcondes
Anabolic Androgenic Steroids (AASs) misuse has increased among adolescents and recreational athletes due to their potential effects on muscle hypertrophy. On the other hand, AAS might induce alterations on cardiovascular system, although some controversies regarding AAS on vascular properties remain unknown. To address this question, we aimed to investigate the effects of high doses of nandrolone combined with strenuous resistance training (RT) on function and structure of thoracic aorta. Rats were randomized into four groups: non-trained vehicle (NTV), trained vehicle (TV), non-trained nandrolone (NTN), and trained nandrolone (TN), and submitted to 6 weeks of treatment with nandrolone (5mg/kg, twice a week) and/or resistance training...
January 6, 2018: Steroids
https://www.readbyqxmd.com/read/29314252/concomitant-repair-of-vascular-ring-with-kommerell-s-diverticulum-and-ventricular-septal-defect
#6
Min Namkoong, Do Yeon Kim, Cheul Lee
No abstract text is available yet for this article.
January 4, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29311752/computational-design-and-synthesis-of-novel-fluoro-analogs-of-combretastatins-a-4-and-a-1
#7
Yao Zong, Christie Shea, Katherine Maffucci, Iwao Ojima
Combretastatin A-1 (CA-1) and combretastatin A-4 (CA-4) isolated from the African bush willow Combretum caffrum are highly potent tubulin polymerization inhibitors, possessing strong antitumor activities because of their vascular disrupting properties. Extensive SAR studies have been done for CA-4 analogs. Because of poor solubility, water-soluble prodrugs of CA-4 and CA-1 have been developed, which are currently in human clinical trials. Fluorine plays an important role in the current drug discovery and development due to its unique properties...
November 2017: Journal of Fluorine Chemistry
https://www.readbyqxmd.com/read/29307026/correlation-of-symptoms-with-bronchoscopic-findings-in-children-with-a-prenatal-diagnosis-of-a-right-aortic-arch-and-left-arterial-duct
#8
Trisha V Vigneswaran, Eva Kapravelou, Aaron J Bell, Andrew Nyman, Kuberan Pushparajah, John M Simpson, Andrew Durward, Vita Zidere
A right aortic arch (RAA) with a left arterial duct (LAD) together encircle the trachea and have the potential to cause tracheobronchial compression and published guidelines recommend bronchoscopy in symptomatic patients. The aim of the study was to describe the incidence of tracheal compression in a cohort of prenatally diagnosed RAA and LAD. Retrospective review of clinical course and imaging of prenatal cases of RAA and LAD assessed with flexible bronchoscopy over an 11-year period. 34 cases of prenatally diagnosed RAA with LAD underwent bronchoscopy at median age of 9 months (range 0...
January 6, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29296067/an-incomplete-vascular-ring-causing-respiratory-distress
#9
Syeda Samar Sohail, Muhammad Tariq, Muneer Amanullah
Kommerell's diverticulum is a rare saccular aneurysmal dilation of the descending aorta. We report a case of a 3.5-year-old boy with the extremely rare combination of Kommerell's diverticulum with a right descending aorta and proximal patent ductus arteriosus aneurysm forming an incomplete vascular ring. To our knowledge, this rare case has not been reported to date.
January 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29295590/proposal-of-a-novel-natural-biomaterial-the-scleral-ossicle-for-the-development-of-vascularized-bone-tissue-in-vitro
#10
Marta Checchi, Jessika Bertacchini, Giulia Grisendi, Alberto Smargiassi, Antonella Sola, Massimo Messori, Carla Palumbo
Recovering of significant skeletal defects could be partially abortive due to the perturbations that affect the regenerative process when defects reach a critical size, thus resulting in a non-healed bone. The current standard treatments include allografting, autografting, and other bone implant techniques. However, although they are commonly used in orthopedic surgery, these treatments have some limitations concerning their costs and their side effects such as potential infections or malunions. On this account, the need for suitable constructs to fill the gap in wide fractures is still urgent...
December 25, 2017: Biomedicines
https://www.readbyqxmd.com/read/29291445/design-synthesis-and-biological-evaluation-of-novel-ring-opened-cromakalim-analogues-with-relaxant-effects-on-vascular-and-respiratory-smooth-muscles-and-as-stimulators-of-elastin-synthesis
#11
Mourad Bouhedja, Basile Peres, Wassim Fhayli, Zeinab Ghandour, Ahcène Boumendjel, Gilles Faury, Smail Khelili
Two new series of ring-opened analogues of cromakalim bearing sulfonylurea moieties (series A: with N-unmethylated sulfonylureas, series B: with N-methylated sulfonylureas) were synthesized and tested as relaxants of vascular and respiratory smooth muscles (rat aorta and trachea, respectively). Ex vivo biological evaluations indicated that the most active compounds, belonging to series B, displayed a marked vasorelaxant activity on endothelium-intact aortic rings and the trachea. A majority of series B compounds exhibited a higher vasorelaxant activity (EC50 < 22 μM) than that of the reference compound diazoxide (EC50 = 24 μM)...
December 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29290815/desacetylvinblastine-monohydrazide-disrupts-tumor-vessels-by-promoting-ve-cadherin-internalization
#12
Xueping Lei, Minfeng Chen, Maohua Huang, Xiaobo Li, Changzheng Shi, Dong Zhang, Liangping Luo, Youwei Zhang, Nan Ma, Heru Chen, Huafeng Liang, Wencai Ye, Dongmei Zhang
Vinca alkaloids, the well-known tubulin-binding agents, are widely used for the clinical treatment of malignant tumors. However, little attention has been paid to their vascular disrupting effects, and the underlying mechanisms remain largely unknown. This study aims to investigate the vascular disrupting effect and the underlying mechanisms of vinca alkaloids. Methods: The capillary disruption assay and aortic ring assay were performed to evaluate the in vitro vascular disrupting effect of desacetylvinblastine monohydrazide (DAVLBH), a derivate of vinblastine, and the in vivo vascular disrupting effect was assessed on HepG2 xenograft model using magnetic resonance imaging, hematoxylin and eosin staining and immunohistochemistry...
2018: Theranostics
https://www.readbyqxmd.com/read/29284268/an-injectable-hydrogel-with-slow-degradability-composed-of-gelatin-and-hyaluronic-acid-crosslinked-by-schiff-s-base-formation
#13
Takuro Hozumi, Tatsuto Kageyama, Seiichi Ohta, Junji Fukuda, Taichi Ito
We developed an injectable gelatin/hyaluronic acid hydrogel with slow degradability, which consisted of carbohydrazide-modified gelatin (Gel-CDH) and hyaluronic acid mono-aldehyde (HA-mCHO). Gel-CDH/HA-mCHO hydrogels were degraded much more slowly in phosphate-buffered saline than other Schiff's base crosslinked gelatin/hyaluronic acid hydrogels that were comprised of native gelatin, adipic acid dihydrazide-modified gelatin, or hyaluronic acid di-aldehyde because of stable Schiff's base formation between aldehyde and carbohydrazide groups, and suppression of ring-opening oxidation by mono-aldehyde modification...
December 29, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29279024/ultrafine-particulate-matter-exposure-impairs-vasorelaxant-response-in-superoxide-dismutase-2-deficient-murine-aortic-rings
#14
Jacqueline D Carter, Nageswara R Madamanchi, George A Stouffer, Marschall S Runge, Wayne E Cascio, Haiyan Tong
Studies have linked exposure to ultrafine particulate matter (PM) and adverse cardiovascular events. PM-induced oxidative stress is believed to be a key mechanism underlying observed adverse vascular effects. Advanced age is one factor known to decrease antioxidant defenses and confer susceptibility to the detrimental vascular effects seen following PM exposure. The present study was designed to investigate the vasomotor responses following ultrafine PM exposure in wild type (WT) and superoxide dismutase 2-deficient (SOD2+/-) mice that possess decreased antioxidant defense...
December 26, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29278444/%C3%AE-adrenergic-receptor-blocker-ici-118-551-selectively-increases-intermediate-conductance-calcium-activated-potassium-channel-ikca-mediated-relaxations-in-rat-main-mesenteric-artery
#15
Melike Hacer Ozkan, Serdar Uma
Endothelial IKCa and/or SKCa channels play an important role in the control of vascular tone by participating in endothelium-dependent relaxation. Whether β-AR antagonists, mainly used in hypertension, affect endothelial KCa channel function is unknown. In this study, we examined the effect of the β2-AR antagonist and inverse agonist ICI 118,551 on the IKCa /SKCa channel activity by assessing functional relaxation responses to several agonists that stimulate these channels. Mesenteric arterial rings isolated from male Spraque-Dawley mounted to organ baths...
December 26, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29251642/l-arginine-and-arginase-products-potentiate-dexmedetomidine-induced-contractions-in-the-rat-aorta
#16
Emily S W Wong, Ricky Y K Man, Kwok F J Ng, Susan W S Leung, Paul M Vanhoutte
BACKGROUND: The α2-adrenergic sedative/anesthetic agent dexmedetomidine exerts biphasic effects on isolated arteries, causing endothelium-dependent relaxations at concentrations at or below 30 nM, followed by contractions at higher concentrations. L-arginine is a common substrate of endothelial nitric oxide synthase and arginases. This study was designed to investigate the role of L-arginine in modulating the overall vascular response to dexmedetomidine. METHODS: Isometric tension was measured in isolated aortic rings of Sprague Dawley rats...
December 15, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29248696/vasodilator-and-hypotensive-effects-of-the-spider-peptide-lycosin-i-in-vitro-and-in-vivo
#17
Binbin Ma, Zhouhuan Xi, Jiahui Li, Tianqi Gao, Runzhi Liao, Shuhang Wang, Xianyao Li, Yaqin Tang, Zheng Wang, Shengjie Hou, Jinying Jiang, Meichun Deng, Zhigui Duan, Xing Tang, Liping Jiang
Lycosin-I, a spider peptide isolated from the venom of the spider Lycosa singoriensis, has anti-bacteria and anti-cancer properties in organisms. However, cardiovascular effects of Lycosin-I have not been studied. In this study, we investigated for the first time the vasodilator and hypotensive effects of Lycosin-I and the possible mechanisms, in order to develop a promising treatment for hypertension-related diseases. For in vitro experiments, thoracic aortas were isolated, and divided into two groups, endothelium-intact and endothelium-denuded aortic rings...
December 14, 2017: Peptides
https://www.readbyqxmd.com/read/29248031/double-aortic-arch-presenting-as-neonatal-respiratory-failure-in-the-delivery-room
#18
Marc Lee, T K Susheel Kumar, Govinda Paudel
Respiratory symptoms are prevalent in vascular ring anomalies, including double aortic arch, which is considered the most common type of vascular ring. However, respiratory failure owing to critical airway obstruction in the neonatal period is rare with few reported cases in the literature. We report a case of a newborn patient who required emergent intubation within the first few hours of life and was later discovered to have a double aortic arch.
December 17, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29242099/downregulation-of-circulating-mots-c-levels-in-patients-with-coronary-endothelial-dysfunction
#19
Qing Qin, Silvia Delrio, Junxiang Wan, R Jay Widmer, Pinchas Cohen, Lilach O Lerman, Amir Lerman
BACKGROUND: MOTS-c is one of the newly identified mitochondrial-derived peptides which play a role in regulating metabolic homeostasis. The current study aimed to investigate whether circulating MOTS-c levels are also associated with endothelial dysfunction(ED) in patients without significant structural coronary lesions. METHODS: Forty patients undergoing coronary angiography and endothelial function testing for clinical indications of recurrent angina with no structural coronary lesions were included in the study...
December 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29229756/decoding-the-molecular-switches-of-natriuretic-peptides-which-differentiate-its-vascular-and-renal-functions
#20
Sindhuja Sridharan, R Manjunatha Kini
Heart failure (HF) is associated with high morbidity and mortality. Dysfunction of blood pressure and/or volume homeostatic processes result in lower perfusion and/or congestion. Treatment strategies exerting differential effects on pressure and volume mechanisms are critical in handling patients with HF. Atrial natriuretic peptides (ANP) is a key hormone in maintaining circulation. It binds to NP receptor-A (NPR-A) on vasculature, kidneys and nervous system to lowers blood pressure and volume. It exerts a concentration-dependent pharmacological activity; only increased renal excretion of water and sodium at low doses and vasodilation along with renal effects at slightly higher doses...
December 11, 2017: Biochemical Journal
keyword
keyword
14121
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"