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Vascular ring

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https://www.readbyqxmd.com/read/28316928/double-aortic-arch-diagnosed-in-a-44-year-old-woman-with-recurring-respiratory-infections
#1
Ana Fenández-Tena, Cristina Martínez-González
Complete vascular rings are originated because of the persistence of the fourth aortic arches, which surround the trachea and esophagus partially or completely, compressing them. The most common type of complete vascular ring is the double aortic arch. Symptoms usually appear in the first months of life, and are provoked by esophageal and tracheal compression. The diagnosis is usually made through the chest X-ray and the esophagogram in patients with dysphagia. We present a case in which the diagnosis of a double aortic arch was made in adulthood, suspected through a spirometry test and a chest X-ray...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28306357/asthma-causes-inflammation-of-human-pulmonary-arteries-and-decreases-vasodilatation-induced-by-prostaglandin-i2-analogs
#2
Nabil Foudi, Aouatef Badi, Mounira Amrane, Wassim Hodroj
OBJECTIVE: Asthma is a chronic inflammatory disease associated with increased cardiovascular events. This study assesses the presence of inflammation and the vascular reactivity of pulmonary arteries in patients with acute asthma. METHODS: Rings of human pulmonary arteries obtained from non-asthmatic and asthmatic patients were set up in organ bath for vascular tone monitoring. Reactivity was induced by vasoconstrictor and vasodilator agents. Protein expression of inflammatory markers was detected by western blot...
February 21, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28301412/large-silicone-droplets-after-intravitreal-bevacizumab-avastin
#3
Robert L Avery, Alessandro A Castellarin, Dilsher S Dhoot, Dante J Pieramici, Maʼan A Nasir, Nathan C Steinle, Logan P Avery, Gabriel M Gordon
PURPOSE: Despite its off-label status, intravitreal bevacizumab is the most commonly used intraocular anti-vascular endothelial growth factor agent. Regulation of compounding pharmacies has recently increased to make compounded pharmaceuticals safer. Despite these changes, a marked increase in symptomatic, large silicone oil droplets following intravitreal bevacizumab injections was noticed. METHODS: Retrospective chart review was performed. Within a single private practice, patients who were noted to have large or symptomatic silicone oil bubbles after an intravitreal injection were reviewed...
March 15, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28286334/mechanical-strain-induced-expression-of-matrix-metalloproteinase-9-via-stretch-activated-channels-in-rat-abdominal-aortic-dissection
#4
ZhiHuang Qiu, LiangWan Chen, Hua Cao, Qiang Chen, Hua Peng
BACKGROUND The aim of the study was to investigate the expression of matrix metalloproteinase-9 (MMP-9) in rat abdominal aortic dissection (AD) induced by mechanical strain, so as to offer a better understanding of the possible mechanisms of AD. MATERIAL AND METHODS Experimental AD in rats was achieved by the injection of porcine pancreatic elastase. At days 0, 1, 3, 5, 7, 14, 21, and 30 after the establishment of AD model, serum MMP-9 levels were measured by enzyme-linked immunosorbent assay (ELISA). Four groups of vascular rings were stretched in vitro with a mechanical strength of 0 g, 1 g, 3 g, or 5 g for 30 min...
March 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28286123/the-enhancement-of-txa2-receptors-mediated-contractile-response-in-intrarenal-artery-dysfunction-in-type-2-diabetic-mice
#5
Su-Juan Kuang, Jie-Sheng Qian, Hui Yang, Fang Rao, Xiao-Yan Chen, Meng-Zhen Zhang, Zhi-Xin Shan, Qiu-Xiong Lin, Yu-Mei Xue, Shu-Lin Wu, Li Jiang, Chun-Bo Chen, Chun-Yu Deng
Thromboxane A2 (TXA2) has been implicated in the pathogenesis of diabetic vascular complications, although the underlying mechanism remains unclear. The present study investigated the alterations in TXA2 receptor signal transduction in type 2 diabetic renal arteries. The contraction of renal arterial rings in control (db/m+) mice and type 2 diabetic (db/db) mice was measured by a Multi Myograph System. Intracellular calcium concentration ([Ca(2+)]i) in vascular smooth muscle cells was measured by Fluo-4/AM dye and confocal laser scanning microscopy...
March 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28285997/ccm-3-promotes-c-%C3%A2-elegans-germline-development-by-regulating-vesicle-trafficking-cytokinesis-and-polarity
#6
Swati Pal, Benjamin Lant, Bin Yu, Ruilin Tian, Jiefei Tong, Jonathan R Krieger, Michael F Moran, Anne-Claude Gingras, W Brent Derry
Cerebral cavernous malformations (CCMs) are vascular defects of the CNS that arise from loss of integrity of the endothelial cells lining blood capillaries, causing leakage of blood into the brain [1]. This results in headaches, seizures, and/or hemorrhagic stroke, depending on the location of the lesion. CCM affects 0.5% of the population and follows an autosomal dominant inheritance pattern caused by mutations in one of the three genes: CCM1 (gene name KRIT1), CCM2 (also known as malcavernin or OSM), and CCM3 (gene name PDCD10) [2, 3], with the earliest onset and most severe prognosis occurring in CCM3 patients [4]...
March 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28285190/nitrate-decreases-xanthine-oxidoreductase-mediated-nitrite-reductase-activity-and-attenuates-vascular-and-blood-pressure-responses-to-nitrite
#7
Célio Damacena-Angelis, Gustavo H Oliveira-Paula, Lucas C Pinheiro, Eduardo J Crevelin, Rafael L Portella, Luiz Alberto B Moraes, Jose E Tanus-Santos
Nitrite and nitrate restore deficient endogenous nitric oxide (NO) production as they are converted back to NO, and therefore complement the classic enzymatic NO synthesis. Circulating nitrate and nitrite must cross membrane barriers to produce their effects and increased nitrate concentrations may attenuate the nitrite influx into cells, decreasing NO generation from nitrite. Moreover, xanthine oxidoreductase (XOR) mediates NO formation from nitrite and nitrate. However, no study has examined whether nitrate attenuates XOR-mediated NO generation from nitrite...
March 6, 2017: Redox Biology
https://www.readbyqxmd.com/read/28283728/survey-of-gadolinium-based-contrast-agent-utilization-among-the-members-of-the-society-for-pediatric-radiology-a-quality-and-safety-committee-report
#8
Einat Blumfield, Michael M Moore, Mary K Drake, Thomas R Goodman, Kristopher N Lewis, Laura T Meyer, Thang D Ngo, Christina Sammet, Arta Luana Stanescu, David W Swenson, Thomas L Slovis, Ramesh S Iyer
BACKGROUND: Gadolinium-based contrast agents (GBCAs) have been used for magnetic resonance (MR) imaging over the last three decades. Recent reports demonstrated gadolinium retention in patients' brains following intravenous administration. Since gadolinium is a highly toxic heavy metal, there is a potential for adverse effects from prolonged retention or deposition, particularly in children. For this reason, the Society (SPR) for Pediatric Radiology Quality and Safety committee conducted a survey to evaluate the current status of GBCAs usage among pediatric radiologists...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28272435/enhancing-adsorption-of-u-vi-onto-edta-modified-l-cylindrica-using-epichlorohydrin-and-ethylenediamine-as-a-bridge
#9
Shouzheng Su, Qi Liu, Jingyuan Liu, Hongsen Zhang, Rumin Li, Xiaoyan Jing, Jun Wang
Benefiting from strong coordination ability and unique vascular structure, EDTA modified L. cylindrica opens up an alternative way for uranium recovery from seawater. However, limitations, such as poor adsorption capacity and slow adsorption rate due to low graft ratio of EDTA via one-step esterification block its practical application. Here, a strategy for increasing the graft ratio is proposed in order to improve the adsorption performance. The strategy initially involves immobilization of epichlorohydrin (EPI) onto L...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28271088/axillary-artery-injury-associated-with-proximal-humerus-fracture-a-report-of-6-cases
#10
Rinne M Peters, Mariano E Menendez, Jos J Mellema, David Ring, R Malcolm Smith
Proximal humerus fractures are common, but associated injury of the axillary artery is uncommon. The majority of published blunt traumatic axillary artery injuries are associated with anterior glenohumeral dislocation; a few are associated with isolated proximal humerus fractures or fracture-dislocation. Experience within our institution demonstrates that axillary artery injury is often unrecognized on initial presentation owing to palpable peripheral pulses and the absence of ischemia and places the hand at risk of necrosis and amputation if there is prolonged ischemia and the forearm at risk of compartment syndrome after revascularization...
January 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28265405/22q11-2-microduplication-syndrome-with-associated-esophageal-atresia-tracheo-esophageal-fistula-and-vascular-ring
#11
Linda T Nguyen, Rachel Fleishman, Emilee Flynn, Rajeev Prasad, Achintya Moulick, Cesar Igor Mesia, Sue Moyer, Reena Jethva
This case report describes a patient with a 22q11.2 duplication. His features, which include VACTERL association with an esophageal atresia/tracheo-esophageal fistula and a vascular ring, expand the previously described phenotype for this duplication.
March 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28264657/-non-alcoholic-fatty-liver-disease-and-enos-dysfunction-in-humans
#12
Marcello Persico, Mario Masarone, Antonio Damato, Mariateresa Ambrosio, Alessandro Federico, Valerio Rosato, Tommaso Bucci, Albino Carrizzo, Carmine Vecchione
BACKGROUND: NAFLD is associated to Insulin Resistance (IR). IR is responsible for Endothelial Dysfunction (ED) through the impairment of eNOS function. Although eNOS derangement has been demonstrated in experimental models, no studies have directly shown that eNOS dysfunction is associated with NAFLD in humans. The aim of this study is to investigate eNOS function in NAFLD patients. METHODS: Fifty-four NAFLD patients were consecutively enrolled. All patients underwent clinical and laboratory evaluation and liver biopsy...
March 7, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28258494/three-rings-for-the-evolution-of-plastid-shape-a-tale-of-land-plant-ftsz
#13
Christopher Grosche, Stefan A Rensing
Nuclear-encoded plant FtsZ genes are derived from endosymbiotic gene transfer of cyanobacteria-like genes. The green lineage (Chloroplastida) and red lineage (Rhodophyta) feature FtsZ1 and FtsZ2 or FtsZB and FtsZA, respectively, which are involved in plastid division. These two proteins show slight differences and seem to heteropolymerize to build the essential inner plastid division ring. A third gene, encoding FtsZ3, is present in glaucophyte and charophyte algae, as well as in land plants except ferns and angiosperms...
March 3, 2017: Protoplasma
https://www.readbyqxmd.com/read/28253265/structurally-simplified-biphenyl-combretastatin-a4-derivatives-retain-in-vitro-anti-cancer-activity-dependent-on-mitotic-arrest
#14
Daniel Tarade, Dennis Ma, Christopher Pignanelli, Fadi Mansour, Daniel Simard, Sean van den Berg, James Gauld, James McNulty, Siyaram Pandey
The cis-stilbene, combretastatin A4 (CA4), is a potent microtubule targeting and vascular damaging agent. Despite promising results at the pre-clinical level and extensive clinical evaluation, CA4 has yet to be approved for therapeutic use. One impediment to the development of CA4 is an inherent conformational instability about the ethylene linker, which joins two aromatic rings. We have previously published preliminary data regarding structurally simplified biphenyl derivatives of CA4, lacking an ethylene linker, which retain anti-proliferative and pro-apoptotic activity, albeit at higher doses...
2017: PloS One
https://www.readbyqxmd.com/read/28243494/arborizing-vessels-in-a-targetoid-hemosiderotic-hemangioma-mistaken-dermoscopic-diagnosis-of-basal-cell-carcinoma
#15
María L Enei, Francisco M Paschoal, Rodrigo Valdes
Targetoid hemosiderotic hemangioma (THH) or hobnail hemangioma (HH) is a benign vascular lesion that presents with the classical clinical presentation of a ring-shaped tumor having a targetoid appearance, with a central purple-brown papule surrounded by a thin pale area and an ecchymotic ring on the outside. Dermoscopic features and patterns of HH have been documented and have proven to be sufficient to establish a clinical diagnosis in many cases. We present a facial lesion in which both the clinical presentation and dermoscopy were atypical...
January 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28243109/prognostic-value-of-increased-expression-of-raco-1-in-patients-with-hepatitis-b-related-hepatocellular-carcinoma
#16
Jian-Yao Chen, Li-Ping Liu, Jiang-Feng Xu
RING domain AP-1 coactivator-1 (RACO-1) is a coactivator that links c-Jun to growth factor signaling and is essential for AP-1 function. This study aimed to investigate the expression and clinical significance of RACO-1 protein in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in China. A total of 136 tissue samples of HBV-related HCC were detected by immunohistochemistry (including 76 patients in training cohort and 60 patients in validation cohort). Correlation between RACO-1 expression and clinicopathologic features of HBV-related HCC was analyzed in both the cohorts...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28237267/trpc5-channel-modulates-endothelial-cells-senescence
#17
Zhengtao Li, Gang Guo, Hongrui Wang, Xiaoqin Si, Guoli Zhou, Yong Xiong, Sujuan Li, Rong Dai, Cui Yang
As a Ca(2+)-permeable cationic channel, canonical transient receptor potential 5 channel (TRPC5) has been known to be involved in various functions of cells. Although TRPC5 is abundantly expressed in vascular endothelium, it remains unknown whether TRPC5 plays a role in regulating endothelial senescence. In the present study, we investigated the involvement of TRPC5 in the senescence of mouse aortic endothelial cells (MAECs). Meanwhile, the regulatory role of TRPC5 in the endothelial dysfunction in aged mice was also studied...
February 22, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28236073/complications-after-percutaneous-internal-fixator-for-anterior-pelvic-ring-injuries
#18
Christian Fang, Hatem Alabdulrahman, Hans-Christophe Pape
OBJECTIVES: The aim of the study is to report on the observed incidence of complications following pedicle screw and rod internal fixator (INFIX) stabilization of pelvic ring fractures. METHODS: In a retrospective review of consecutive patient series conducted in a University level 1 trauma hospital, 43 patients (21 female and eight male), mean age 64.2 (range 16-87) with OTA/AO type B or C pelvic ring fractures received percutaneous pedicle screw and rod internal fixator (INFIX) anterior stabilization of pelvic ring fractures; 29 fulfilled inclusion criteria with three months' minimal follow-up or known complication...
February 24, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28217802/-comparison-of-agonists-induced-contraction-between-main-and-the-third-order-branches-of-pulmonary-arteries-in-rats
#19
Qiu-Hong Huang, Yun-Ping Mu, Fu-Rong Yan, Jie-Ling Zhu, Xiao-Ru Liu, Mo-Jun Lin
This study was designed to observe the differences between main pulmonary arteries and the third-order branches of pulmonary arteries in the contractile response to phenylephrine (Phen), endothelin-1 (ET-1) and potassium chloride (KCl). The vascular tension changes of main and the third-order branches of pulmonary arteries induced by KCl, ET-1 and Phen were recorded by traditional vascular tone detection methods and microvascular ring technique, respectively. The results showed that Phen could cause a significant contraction in main pulmonary arteries, but did not induce apparent contraction in the third-order branches of pulmonary arteries...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28217276/synthesis-and-biological-evaluation-of-benzocyclooctene-based-and-indene-based-anticancer-agents-that-function-as-inhibitors-of-tubulin-polymerization
#20
Christine A Herdman, Tracy E Strecker, Rajendra P Tanpure, Zhi Chen, Alex Winters, Jeni Gerberich, Li Liu, Ernest Hamel, Ralph P Mason, David J Chaplin, Mary Lynn Trawick, Kevin G Pinney
The natural products colchicine and combretastatin A-4 (CA4) have been inspirational for the design and synthesis of structurally related analogues and spin-off compounds as inhibitors of tubulin polymerization. The discovery that a water-soluble phosphate prodrug salt of CA4 (referred to as CA4P) is capable of imparting profound and selective damage to tumor-associated blood vessels paved the way for the development of a new therapeutic approach for cancer treatment utilizing small-molecule inhibitors of tubulin polymerization that also act as vascular disrupting agents (VDAs)...
December 1, 2016: MedChemComm
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