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https://www.readbyqxmd.com/read/28726262/double-aortic-arch-anomalies-in-children-a-systematic-20-year-single-center-study
#1
M Kaldararova, I Simkova, I Varga, P Tittel, M Kardos, M Ondriska, V Vrsanska, J Masura
INTRODUCTION: Aortic arch anomalies underlie numerous congenital disorders. Effectively diagnosing and treating them requires close understanding of cardiovascular embryology. As our Center serves the entire pediatric population of our country, we performed a comprehensive retrospective analysis of all aortic arch anomalies diagnosed at our Center over the past 20 years. MATERIALS AND METHODS: We analyzed 40 children with aortic arch anomalies, distinguishing two defect types: Group 1 displayed ring-forming anomalies, and Group 2 other types of aortic arch anomalies that did not form a vascular ring...
July 20, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28725933/-callus-distraction-and-bone-transport-in-the-treatment-of-bone-defects
#2
REVIEW
R Baumgart, B Schuster, T Baumgart
BACKGROUND: The method of "callus distraction" is the only technique which spontaneously produces vascularized bone within the surrounding soft tissues during lengthening reconstructive procedures. Remodeling of the regenerate bone to specific mechanical load can be influenced by the surgeon. In principle, there is no limit to the amount of new bone formation which can be created; this vascularized bone is both resistant to infection and can be created to replace resected infected bone...
July 19, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28725003/distribution-of-salicifoline-in-freeze-fixed-stems-of-magnolia-kobus-as-observed-by-cryo-tof-sims
#3
Wakaba Okumura, Dan Aoki, Yasuyuki Matsushita, Masato Yoshida, Kazuhiko Fukushima
Alkaloids are basic nitrogen-containing chemicals that have important physiological and pharmacological characteristics. Many vascular plant species contain alkaloids, and their roles in planta are of interest. However, the detailed distribution of alkaloids remains unclear because of their low water solubility and low concentrations in plants. In this study, we visualized the distribution of salicifoline, a water-soluble quaternary ammonium alkaloid, in the freeze-fixed stems of Magnolia kobus by cryo time-of-flight secondary ion mass spectrometry...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28721160/genetic-disruption-of-multidrug-resistance-associated-protein-1-improves-endothelial-function-and-attenuates-atherosclerosis-in-mrp1-ldlr-double-knockout-mice
#4
Julian Jehle, Cornelius F H Müller, Adem Aksoy, Sebastian Zimmer, Georg Nickenig, Vedat Tiyerili
INTRODUCTION: Multidrug resistance-associated protein 1 (MRP1) is an anion transporter which is implicated in the efflux of the intracellular antioxidant anion glutathione as well as leukotrienes. Pharmacological inhibition of MRP1 exhibits antioxidative and anti-atherosclerotic effects both in vitro and in vivo. However, pharmacological inhibitors of MRP1 lack selectivity, which prompted us to study the in vivo impact of a genetic disruption of MRP1 on endothelial dysfunction, reactive oxygen species formation and atherogenesis in an atherosclerotic mouse model...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28719636/the-non-diuretic-hypotensive-effects-of-thiazides-are-enhanced-during-volume-depletion-states
#5
Saeed Alshahrani, Robert M Rapoport, Kamyar Zahedi, Min Jiang, Michelle Nieman, Sharon Barone, Andrea L Meredith, John N Lorenz, Jack Rubinstein, Manoocher Soleimani
Thiazide derivatives including Hydrochlorothiazide (HCTZ) represent the most common treatment of mild to moderate hypertension. Thiazides initially enhance diuresis via inhibition of the kidney Na+-Cl- Cotransporter (NCC). However, chronic volume depletion and diuresis are minimal while lowered blood pressure (BP) is maintained on thiazides. Thus, a vasodilator action of thiazides is proposed, likely via Ca2+-activated K+ (BK) channels in vascular smooth muscles. This study ascertains the role of volume depletion induced by salt restriction or salt wasting in NCC KO mice on the non-diuretic hypotensive action of HCTZ...
2017: PloS One
https://www.readbyqxmd.com/read/28718964/antiangiogenic-effects-of-ziyuglycoside-ii-a-major-active-compound-of-sanguisorba-officinalis-l
#6
Sang-Hyeon Nam, Khaliunaa Lkhagvasuren, Hee Won Seo, Jin-Kyung Kim
Ziyuglycoside II, a major bioactive compound of Sanguisorba officinalis L., displays anticancer potential against several human cancer cells. However, little information concerning its antiangiogenic properties and possible mechanisms is available. The aim of this study was to investigate the inhibitory effects of ziyuglycoside II on angiogenesis. Ziyuglycoside II inhibited the proliferation, migration, and tubule formation of human umbilical vein endothelial cells, as well as the number of microvessels growing from the aortic rings...
July 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28715444/pyrrolidine-dithiocarbamate-ameliorates-endothelial-dysfunction-in-thoracic-aorta-of-diabetic-rats-by-preserving-vascular-ddah-activity
#7
Chang-Wu Lu, Yuan Lin, Yan-Ping Lei, Lan Wang, Zhi-Min He, Yan Xiong
OBJECTIVE: Endothelial dysfunction plays a pivotal role in the development of diabetic cardiovascular complications. Accumulation of endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) and inhibition of dimethylarginine dimethylaminohydrolase (DDAH) activity have been involved in diabetic endothelial dysfunction. This study was to investigate the effect of pyrrolidine dithiocarbamate (PDTC) on impairment of endothelium-dependent vasodilatation in diabetic rats and its potential mechanism...
2017: PloS One
https://www.readbyqxmd.com/read/28714905/effects-of-eicosapentaenoic-acid-epa-and-docosahexaenoic-acid-dha-on-fetal-pulmonary-circulation-an-experimental-study-in-fetal-lambs
#8
Dyuti Sharma, Estelle Aubry, Thavarak Ouk, Ali Houeijeh, Véronique Houfflin-Debarge, Rémi Besson, Philippe Deruelle, Laurent Storme
Background: Persistent pulmonary hypertension of the newborn (PPHN) causes significant morbidity and mortality in neonates. n-3 Poly-unsaturated fatty acids have vasodilatory properties in the perinatal lung. We studied the circulatory effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in fetal sheep and in fetal pulmonary arterial rings. Methods: At 128 days of gestation, catheters were placed surgically in fetal systemic and pulmonary circulation, and a Doppler probe around the left pulmonary artery (LPA)...
July 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28705794/targeted-disruption-of-jcad-junctional-protein-associated-with-coronary-artery-disease-kiaa1462-a-coronary-artery-disease-associated-gene-product-inhibits-angiogenic-processes-in-vitro-and-in-vivo
#9
Tetsuya Hara, Tomoko Monguchi, Noriko Iwamoto, Masaya Akashi, Kenta Mori, Toshihiko Oshita, Mitsumasa Okano, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Yui Yamashita, Go Shioi, Mikio Furuse, Tatsuro Ishida, Ken-Ichi Hirata
OBJECTIVE: Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease), is unknown. Because JCAD is expressed at cell-cell junctions in endothelial cells, we hypothesized and tested whether JCAD regulates angiogenic processes in vitro and in vivo. APPROACH AND RESULTS: Cell culture experiments revealed impaired angiogenic ability (proliferation, migration, and cord formation) by the knockdown of JCAD with siRNA (P<0...
July 13, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28700905/chronic-iron-overload-induces-functional-and-structural-vascular-changes-in-small-resistance-arteries-via-nadph-oxidase-dependent-o2-production
#10
Rogério Faustino Ribeiro, Vinicius Bermond Marques, Dieli Oliveira Nunes, Ivanita Stefanon, Leonardo Dos Santos
Iron overload leads to excessive free radical formation and induces cardiovascular dysfunction. Thus, our aim was to investigate the structural and endothelial modulation of vascular tone induced by chronic iron overload in mesenteric arteries. Rats were divided into two groups: the control (vehicle) group and the group treated with iron dextran for 28days (100mg/kg, 5days a week). Chronic iron overload altered the following morpho-physiological parameters of third-order mesenteric resistance arteries: decreased lumen and external diameters; increased wall/lumen ratio and wall thickness; decreased distensibility and increased stiffness; and increased pulse wave velocity...
July 9, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28696873/modified-aortic-uncrossing-procedure-a-novel-approach-for-norwood-palliation-of-complex-univentricular-congenital-heart-disease-with-a-circumflex-aorta
#11
Roosevelt Bryant, William Wallen, Raheel Rizwan, David L Morales
The circumflex aorta is a rare type of true vascular ring anomaly. It consists of a retroesophageal right aortic arch, a left-sided descending thoracic aorta, and a left-sided ligamentum arteriosum. The "aortic uncrossing procedure" described by Planché and Lacour-Gayet is the procedure of choice for managing this aortic anomaly in patients with a biventricular heart. The presence of a circumflex aorta in a patient with heterotaxy syndrome and univentricular congenital heart disease requiring Norwood palliation is highly unusual...
July 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28689502/intrauterine-growth-restriction-induced-deleterious-adaptations-in-endothelial-progenitor-cells-possible-mechanism-to-impair-endothelial-function
#12
V Oliveira, L V de Souza, T Fernandes, S D S Junior, M H C de Carvalho, E H Akamine, L C Michelini, E M de Oliveira, M D C Franco
Intrauterine growth restriction (IUGR) can induce deleterious changes in the modulatory ability of the vascular endothelium, contributing to an increased risk of developing cardiovascular diseases in the long term. However, the mechanisms involved are not fully understood. Emerging evidence has suggested the potential role of endothelial progenitor cells (EPCs) in vascular health and repair. Therefore, we aimed to evaluate the effects of IUGR on vascular reactivity and EPCs derived from the peripheral blood (PB) and bone marrow (BM) in vitro...
July 10, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28682018/vascular-displacement-in-idiopathic-macular-hole-after-single-layered-inverted-internal-limiting-membrane-flap-surgery
#13
Jae Jung Lee, In Ho Lee, Keun Heung Park, Kang Yeun Pak, Sung Who Park, Ik Soo Byon, Ji Eun Lee
PURPOSE: To compare vascular displacement in the macula after surgical closure of idiopathic macular hole (MH) after single-layered inverted internal limiting membrane (ILM) flap technique and conventional ILM removal. METHODS: This retrospective study included patients who underwent either vitrectomy and ILM removal only or vitrectomy with single-layered inverted ILM flap for idiopathic MH larger than 400 μm from 2012 to 2015. A customized program compared the positions of the retinal vessels in the macula between preoperative and postoperative photographs...
June 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28681466/a-case-of-complete-double-aortic-arch-visualized-by-transthoracic-echocardiography
#14
Naka Saito, Shingo Kato, Noritaka Saito, Tatsuya Nakachi, Kazuki Fukui, Tae Iwasawa, Masami Kosuge, Kazuo Kimura
A case of double aortic arch that was well visualized using transthoracic echocardiography is reported. A 38-year-old man underwent transthoracic echocardiography for the evaluation of dyspnea. A suprasternal view of transthoracic echocardiography showed the ascending aorta bifurcate to left and right aortic arches, with blood flow from the ascending aorta to bilateral aortic arches. The diagnosis of right side-dominant double aortic arch was made, and the patient's symptom was conceivably related to compression of the trachea due to a vascular ring...
July 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/28678930/ruthenium-complex-improves-the-endothelial-function-in-aortic-rings-from-hypertensive-rats
#15
Izabela Pereira Vatanabe, Carla Nascimento Dos Santos Rodrigues, Tereza Cristina Buzinari, Thiago Francisco de Moraes, Roberto Santana da Silva, Gerson Jhonatan Rodrigues
Background: The endothelium is a monolayer of cells that extends on the vascular inner surface, responsible for the modulation of vascular tone. By means of the release of nitric oxide (NO), the endothelium has an important protective function against cardiovascular diseases. Objective: Verify if cis- [Ru(bpy)2(NO2)(NO)](PF6)2 (BPY) improves endothelial function and the sensibility of conductance (aorta) and resistance (coronary) to vascular relaxation induced by BPY...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28678928/the-diterpene-sclareol-vascular-effect-in-normotensive-and-hypertensive-rats
#16
Debora Ribeiro Campos, Andrea Carla Celotto, Agnes Afrodite S Albuquerque, Luciana Garros Ferreira, Ariadne Santana E Neves Monteiro, Eduardo Barbosa Coelho, Paulo Roberto Barbosa Evora
Background: The diterpene Sclareol has antimicrobial action, cytotoxic and cytostatic effects and anti-tumor activities. However, researches on the cardiovascular system are scarce. Objective: This study was designed to investigate the mechanisms involved in the Sclareol cardiovascular effect in normotensive and hypertensive rats. Methods: The arterial hypertension was promoted using 2-kidneys 1-clip model in rats. The effect of sclareol on blood pressure was performed by using three dose (10, 20 and 40 mg/kg)...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28667263/effect-of-boron-deficiency-on-anatomical-structure-and-chemical-composition-of-petioles-and-photosynthesis-of-leaves-in-cotton-gossypium-hirsutum-l
#17
Mingfeng Li, Zhuqing Zhao, Zhihua Zhang, Wei Zhang, Jun Zhou, Fangsen Xu, Xinwei Liu
The main symptom of boron (B) deficiency in cotton is the formation of brown rings on leaf petioles. The objective of the present study was to determine the changes in the anatomical structure and chemical composition of petioles and photosynthesis of leaves in cotton under B deficiency. Compared to the control, B deficiency treatment resulted in large increases in the number of petioles with brown rings per plant (160.0%) and the number of rings on the petiole per functional leaf (711.1%) in cotton seedlings...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28666888/antofine-a-natural-phenanthroindolizidine-alkaloid-suppresses-angiogenesis-via-regulation-of-akt-mtor-and-ampk-pathway-in-endothelial-cells-and-endothelial-progenitor-cells-derived-from-mouse-embryonic-stem-cells
#18
Jedo Oh, Gi Dae Kim, Sanghee Kim, Sang Kook Lee
Although antofine, a natural phenanthroindolizidine alkaloid, exerts potential biological activities, including anticancer effect and anti-angiogenic activity, the underlying mechanisms have not yet been investigated. In the present study, the inhibitory effect of antofine on angiogenesis was determined in cultured mouse embryonic stem (mES)/embryoid body (EB)-derived endothelial cells and vascular endothelial growth factor (VEGF)-induced human umbilical vein endothelial cells (HUVECs). Antofine effectively inhibited VEGF-induced cell migration and tube formation of HUVECs...
June 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28655904/danhong-injection-reduces-vascular-remodeling-and-up-regulates-the-kallikrein-kinin-system-in-spontaneously-hypertensive-rats
#19
Xiaohu Yang, John Orgah, Dandan Wang, Guanwei Fan, Hu Jingyang, Jihong Han, Gangjian Qin, Xiumei Gao, Yan Zhu
Although Danhong injection (DHI) is one of the most prescribed cardiovascular medicines in China, its therapeutic indications and mechanisms remain partially defined. We now identify molecular targets of DHI in resistance vasculatures and demonstrate its role in vascular function and blood pressure (BP) regulation. BP was determined in DHI, Losartan, and placebo- treated Spontaneously Hypertensive Rats (SHR) by both noninvasive and invasive measurements. Vasorelaxation was examined both in conduit and resistance vasculature by ex vivo aortic rings...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28653846/in-vivo-and-mechanistic-studies-on-antitumor-lead-7-methoxy-4-2-methylquinazolin-4-yl-3-4-dihydroquinoxalin-2-1h-one-and-its-modification-as-a-novel-class-of-tubulin-binding-tumor-vascular-disrupting-agents
#20
Mu-Tian Cui, Li Jiang, Masuo Goto, Pei-Ling Hsu, Linna Li, Qi Zhang, Lei Wei, Shou-Jun Yuan, Ernest Hamel, Susan L Morris-Natschke, Kuo-Hsiung Lee, Lan Xie
7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one (2), a promising anticancer lead previously identified by us, inhibited tumor growth by 62% in mice at 1.0 mg/kg without obvious signs of toxicity. Moreover, compound 2 exhibited extremely high antiproliferative activity in the NIH-NCI 60 human tumor cell line panel, with low to sub-nanomolar GI50 values (10(-10) M level). It also showed a suitable balance between aqueous solubility and lipophilicity, as well as moderate metabolic stability in vivo...
June 27, 2017: Journal of Medicinal Chemistry
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