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https://www.readbyqxmd.com/read/28930623/multipartner-fertility-in-nicaragua-complex-family-formation-in-a-low-income-setting
#1
Kammi K Schmeer, Jake Hays
CONTEXT: Multipartner fertility (having children with more than one partner) is an important topic in demographic research, but little is known about its incidence and correlates in low-income settings, where rates may be high because of poverty, union instability and early childbearing. METHODS: Data from the 2011-2012 Encuesta Nicaragüense de Demografía y Salud were used to calculate the prevalence of multipartner fertility among 8,320 mothers and 2,141 fathers with two or more children...
March 3, 2017: International Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/28928210/analysis-of-individuals-from-a-dengue-endemic-region-helps-define-the-footprint-and-repertoire-of-antibodies-targeting-dengue-virus-3-type-specific-epitopes
#2
Daniela V Andrade, Leah C Katzelnick, Doug G Widman, Angel Balmaseda, Aravinda M de Silva, Ralph S Baric, Eva Harris
The four dengue virus serotypes (DENV1 to 4) cause dengue, a major public health problem worldwide. Individuals exposed to primary DENV infections develop serotype-specific neutralizing antibodies, including strongly neutralizing antibodies targeting quaternary epitopes. To date, no studies have measured the levels and kinetics of serum antibodies directed to such epitopes among populations in regions where dengue is endemic. Here, we use a recombinant DENV4 (rDENV4/3-M14) displaying a major DENV3 type-specific quaternary epitope recognized by human monoclonal antibody 5J7 to measure the proportion, magnitude, and kinetics of DENV3 type-specific neutralizing antibody responses targeting this epitope...
September 19, 2017: MBio
https://www.readbyqxmd.com/read/28926845/leptospirosis-renal-disease-emerging-culprit-of-chronic-kidney-disease-unknown-etiology
#3
Chih-Wei Yang
Leptospirosis is the most prevalent zoonosis affecting more than 1 million populations worldwide. Interestingly, leptospirosis endemic regions coincide with chronic kidney disease (CKD) hotspots largely due to flooding and agricultural overlaps. Acute leptospirosis induces multiple organ dysfunction including acute kidney injury and may predispose to CKD and end-stage renal disease, if not treated timely. Asymptomatic infection may carry the bacteria in the kidney and CKD progresses insidiously. Histologic finding of leptospirosis renal disease includes tubulointerstitial nephritis, interstitial fibrosis, and tubular atrophy...
September 20, 2017: Nephron
https://www.readbyqxmd.com/read/28923090/mapping-occurrence-of-taenia-solium-taeniosis-cysticercosis-and-areas-at-risk-of-porcine-cysticercosis-in-central-america-and-the-caribbean-basin
#4
Uffe Christian Braae, Brecht Devleesschauwer, Fortune Sithole, Ziqi Wang, Arve Lee Willingham
BACKGROUND: This study aimed to map the occurrence of Taenia solium taeniosis/cysticercosis at national level within Central America and the Caribbean basin, and to map the distribution of porcine cysticercosis at first-level administrative subdivision level (department level) and the porcine population at risk. This zoonotic parasite is believed to be widely endemic across most of Latin America. However, there is little information readily available for Central America and the Caribbean basin...
September 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28919118/global-regional-and-national-disability-adjusted-life-years-dalys-for-333-diseases-and-injuries-and-healthy-life-expectancy-hale-for-195-countries-and-territories-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#5
(no author information available yet)
BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE)...
September 16, 2017: Lancet
https://www.readbyqxmd.com/read/28905388/alcohol-and-road-traffic-injuries-in-latin-america-and-the-caribbean-a-case-crossover-study
#6
Guilherme Borges, Maristela Monteiro, Cheryl J Cherpitel, Ricardo Orozco, Yu Ye, Vladimir Poznyak, Margie Peden, Flavio Pechansky, Mariana Cremonte, Sandra D Reid, Jesus Mendez
BACKGROUND: This study reports dose-response estimates for the odds ratio (OR) and population attributable risk of acute alcohol use and road traffic injury (RTI). METHODS: Data were analyzed on 1,119 RTI patients arriving at 16 emergency departments (EDs) in Argentina, Brazil, Costa Rica, Dominican Republic, Guatemala, Guyana, Mexico, Nicaragua, Panama, and Trinidad and Tobago. Case-crossover analysis, pair-matching the number of standard drinks consumed within the 6 hours prior to the RTI with 2 control periods (prior d/wk), was performed using fractional polynomial analysis for dose-response...
September 13, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28902272/-chikungunya-seroprevalence-and-clinical-case-rate-in-nicaragua-2014-2015
#7
(no author information available yet)
Objective: Estimate seroprevalence, clinical case rate, and proportion of subclinical infections from chikungunya. Methods: A cross-sectional study was conducted in October 2015 at 39 sites distributed across Nicaragua. Demographic and clinical information was compiled through a personal survey. Blood samples were collected to detect chikungunya antibodies using the ELISA inhibition method developed by Nicaragua's National Diagnostic and Reference Center. Results were analyzed using generalized linear models and multilevel Poisson models...
August 21, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28902269/development-of-in-house-serological-methods-for-diagnosis-and-surveillance-of-chikungunya
#8
Saira Saborío Galo, Karla González, Yolanda Téllez, Nadezna García, Leonel Pérez, Lionel Gresh, Eva Harris, Ángel Balmaseda
Objective: To develop and evaluate serological methods for chikungunya diagnosis and research in Nicaragua. Methods: Two IgM ELISA capture systems (MAC-ELISA) for diagnosis of acute chikungunya virus (CHIKV) infections, and two Inhibition ELISA Methods (IEM) to measure total antibodies against CHIKV were developed using monoclonal antibodies (mAbs) and hyperimmune serum at the National Virology Laboratory of Nicaragua in 2014-2015. The sensitivity, specificity, predictive values, and agreement of the MAC-ELISAs were obtained by comparing the results of 198 samples (116 positive; 82 negative) with the Centers for Disease Control and Prevention's IgM ELISA (Atlanta, Georgia, United States; CDC-MAC-ELISA)...
August 21, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28871842/retraction-of-complaints-among-female-victims-of-intimate-partner-violence-living-in-poverty-in-nicaragua
#9
José Juan Vázquez, Esther Rivas, Alexia C Suarez, Sonia Panadero
Retraction among female victims of intimate partner violence (IPV) who report their abuser is a major problem in all societies. This article describes a study of 136 female victims of physical IPV living in poverty in Nicaragua, one of the countries with the lowest levels of development in Central America. This article analyses the aspects that differentiate women living in poverty who retracted after reporting IPV from those who did not. The results show that retraction is widespread among female victims of IPV living in poverty in León (Nicaragua)...
September 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28863466/characterization-of-dengue-virus-infections-among-febrile-children-clinically-diagnosed-with-a-non-dengue-illness-managua-nicaragua
#10
Jesse J Waggoner, Lionel Gresh, Alisha Mohamed-Hadley, Angel Balmaseda, K James Soda, Janaki Abeynayake, Malaya K Sahoo, Yuanyuan Liu, Guillermina Kuan, Eva Harris, Benjamin A Pinsky
Background: We sought to characterize dengue virus (DENV) infections among febrile children enrolled in a pediatric cohort study who were clinically diagnosed with a non-dengue illness ("C cases"). Methods: DENV infections were detected and viral load quantitated by real-time reverse transcription-polymerase chain reaction in C cases presenting between January 2007 and January 2013. Results: One hundred forty-one of 2892 C cases (4.88%) tested positive for DENV...
June 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28860243/complete-genome-sequence-of-frog-virus-3-isolated-from-a-strawberry-poison-frog-oophaga-pumilio-imported-from-nicaragua-into-the-netherlands
#11
Bernardo Saucedo, Joseph Hughes, Steven J van Beurden, Nicolás M Suárez, Olga L M Haenen, Michal Voorbergen-Laarman, Andrea Gröne, Marja J L Kik
Frog virus 3 was isolated from a strawberry poison frog (Oophaga pumilio) imported from Nicaragua via Germany to the Netherlands, and its complete genome sequence was determined. Frog virus 3 isolate Op/2015/Netherlands/UU3150324001 is 107,183 bp long and has a nucleotide similarity of 98.26% to the reference Frog virus 3 isolate.
August 31, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28813518/changes-in-the-incidence-of-pneumonia-bacterial-meningitis-and-infant-mortality-5-years-following-introduction-of-the-13-valent-pneumococcal-conjugate-vaccine-in-a-3-0-schedule
#12
Sylvia Becker-Dreps, Bryan Blette, Rafaela Briceño, Jorge Alemán, Michael G Hudgens, Gilberto Moreno, Ana Ordoñez, Julio Rocha, David J Weber, Erick Amaya
BACKGROUND: Streptococcus pneumoniae causes about 826,000 deaths of children in the world each year and many health facility visits. To reduce the burden of pneumococcal disease, many nations have added pneumococcal conjugate vaccines to their national immunization schedules. Nicaragua was the first country eligible for GAVI Alliance funding to introduce the 13-valent pneumococcal conjugate vaccine (PCV13) in 2010, provided to infants at 2, 4, and 6 months of age. The goal of this study was to evaluate the population impact of the first five years of the program...
2017: PloS One
https://www.readbyqxmd.com/read/28800094/socioeconomic-inequalities-in-visits-to-the-dentist-to-receive-professionally-applied-topical-fluoride-in-a-developing-country
#13
Miriam Del Socorro Herrera, Carlo Eduardo Medina-Solís, América Patricia Pontigo-Loyola, Rubén de la Rosa-Santillana, Leticia Ávila-Burgos, Rogelio José Scougall-Vilchis, Sonia Márquez-Rodríguez, Mirna Minaya-Sánchez, Alejandro José Casanova-Rosado
OBJECTIVE: To determine the frequency and associated factors of visits to the dentist in the last year by Nicaraguan schoolchildren to receive professionally applied topical fluoride (PATF). MATERIAL AND METHODS: A cross-sectional study was designed in children from public schools in the city of León, Nicaragua, were included. A series of socioeconomic, sociodemographic, and behavioural variables were collected through a questionnaire. The dependent variable was the visit to the dentist to receive professionally applied topical fluoride in the last year, which was dichotomised as (0) Did not receive PATF and (1) Yes received PATF...
August 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28792657/rapid-adaptation-to-a-novel-light-environment-the-importance-of-ontogeny-and-phenotypic-plasticity-in-shaping-the-visual-system-of-nicaraguan-midas-cichlid-fish-amphilophus-citrinellus-spp
#14
Andreas Härer, Julián Torres-Dowdall, Axel Meyer
Colonization of novel habitats is typically challenging to organisms. In the initial stage after colonization, approximation to fitness optima in the new environment can occur by selection acting on standing genetic variation, modification of developmental patterns or phenotypic plasticity. Midas cichlids have recently colonized crater Lake Apoyo from great Lake Nicaragua. The photic environment of crater Lake Apoyo is shifted towards shorter wavelengths compared to great Lake Nicaragua and Midas cichlids from both lakes differ in visual sensitivity...
August 9, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28769893/imported-zika-virus-in-a-european-city-how-to-prevent-local-transmission
#15
Joan-Pau Millet, Tomàs Montalvo, Ruben Bueno-Marí, Arancha Romero-Tamarit, Albert Prats-Uribe, Lidia Fernández, Esteve Camprubí, Lucía Del Baño, Victor Peracho, Jordi Figuerola, Elena Sulleiro, Miguel J Martínez, Joan A Caylà
Background: On February 1st 2016 the WHO declared the Zika Virus (ZIKV) infection a worldwide public health emergency because of its rapid expansion and severe complications, such as Guillain-Barré Syndrome or microcephaly in newborn. The huge amount of people traveling to endemic areas and the presence of Aedes albopictus in Barcelona increase the risk of autochtonous transmission. The objective of this study was to describe the first ZIKV cases diagnosed in our city and to analyze the surveillance, prevention, and control measures implemented to avoid autochthonous transmission...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28767103/aflp-diversity-and-spatial-structure-of-calycophyllum-candidissimum-rubiaceae-a-dominant-tree-species-of-nicaragua-s-critically-endangered-seasonally-dry-forest
#16
A Dávila-Lara, M Affenzeller, A Tribsch, V Díaz, H P Comes
The Central American seasonally dry tropical (SDT) forest biome is one of the worlds' most endangered ecosystems, yet little is known about the genetic consequences of its recent fragmentation. A prominent constituent of this biome is Calycophyllum candidissimum, an insect-pollinated and wind-dispersed canopy tree of high socio-economic importance, particularly in Nicaragua. Here, we surveyed amplified fragment length polymorphisms across 13 populations of this species in Nicaragua to elucidate the relative roles of contemporary vs historical factors in shaping its genetic variation...
October 2017: Heredity
https://www.readbyqxmd.com/read/28735597/correlates-and-family-aggregation-of-vitamin-d-concentrations-in-school-aged-children-and-their-parents-in-nine-mesoamerican-countries
#17
Sonia L Robinson, Manuel Ramirez-Zea, Ana Victoria Roman, Eduardo Villamor
OBJECTIVE: To determine the associations of sociodemographic characteristics, diet and outdoor activity as an indicator of sun exposure with serum 25-hydroxyvitamin D (25(OH)D) concentrations in children and their parents from Mesoamerica. We also quantified family aggregation of serum 25(OH)D. DESIGN: Cross-sectional study. Serum 25(OH)D concentrations were quantified using immunoassay. We compared the distribution of 25(OH)D concentrations in adults and children by levels of each correlate with the use of linear regression...
October 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28722618/clinical-evidence-of-acute-mesoamerican-nephropathy
#18
Rebecca S B Fischer, Sreedhar Mandayam, Denis Chavarria, Chandan Vangala, Melissa N Garcia, Linda L Garcia, Lesbia Palma, Felix Garcia, Ramón García-Trabanino, Kristy O Murray
Mesoamerican nephropathy (MeN), an epidemic of unexplained kidney disease in Central America, affects mostly young, healthy individuals. Its etiology is a mystery that requires urgent investigation. Largely described as a chronic kidney disease (CKD), no acute clinical scenario has been characterized. An understanding of the early disease process could elucidate an etiology and guide treatment and prevention efforts. We sought to document the earliest clinical signs in patients with suspected MeN in a high-risk population in Nicaragua...
July 17, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722577/risk-factors-for-norovirus-gastroenteritis-among-nicaraguan-children
#19
Joann F Gruber, Natalie M Bowman, Sylvia Becker-Dreps, Yaoska Reyes, Connor Belson, Kenan C Michaels, Filemon Bucardo
Norovirus is a leading cause of pediatric gastroenteritis. Understanding norovirus epidemiology is essential for reducing disease burden. We conducted a case-control study to describe the distribution, clinical features, and risk factors of norovirus gastroenteritis among children < 5 years of age in León, Nicaragua. Cases were children testing positive for norovirus and controls were children living in the cases' communities. Study staff interviewed mothers of enrolled cases and controls to obtain detailed exposure information including food, water, and sanitation sources; recent exposures; household characteristics; and handwashing practices...
July 10, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28716913/antibody-based-assay-discriminates-zika-virus-infection-from-other-flaviviruses
#20
Angel Balmaseda, Karin Stettler, Raquel Medialdea-Carrera, Damaris Collado, Xia Jin, José Victor Zambrana, Stefano Jaconi, Elisabetta Cameroni, Saira Saborio, Francesca Rovida, Elena Percivalle, Samreen Ijaz, Steve Dicks, Ines Ushiro-Lumb, Luisa Barzon, Patricia Siqueira, David W G Brown, Fausto Baldanti, Richard Tedder, Maria Zambon, A M Bispo de Filippis, Eva Harris, Davide Corti
Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged recently as a global health threat, causing a pandemic in the Americas. ZIKV infection mostly causes mild disease, but is linked to devastating congenital birth defects and Guillain-Barré syndrome in adults. The high level of cross-reactivity among flaviviruses and their cocirculation has complicated serological approaches to differentially detect ZIKV and dengue virus (DENV) infections, accentuating the urgent need for a specific and sensitive serological test...
August 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
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