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https://www.readbyqxmd.com/read/29334019/chemical-stabilization-of-polymers-implications-for-dermal-exposure-to-additives
#1
N Bartsch, M Girard, L Schneider, V Van De Weijgert, A Wilde, O Kappenstein, B Vieth, C Hutzler, A Luch
Technical benefits of additives in polymers stand in marked contrast to their associated health risks. Here, a multi-analyte method based on gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) was developed to quantify polymer additives in complex matrices such as low-density polyethylene (LDPE) and isolated human skin layers after dermal exposure ex vivo. That way both technical aspects and dermal exposure were investigated. The effects of polymer additivation on the material were studied using the example of LDPE...
January 15, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29328485/knockdown-of-hnrnp-a2-b1-inhibits-cell-proliferation-invasion-and-cell-cycle-triggering-apoptosis-in-cervical-cancer-via-pi3k-akt-signaling-pathway
#2
Xiang Shi, Li Ran, Yao Liu, Shu-Huai Zhong, Ping-Ping Zhou, Ming-Xin Liao, Wen Fang
Cervical cancer is currently one of the major threats to women's health. The overexpression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) as the biomarker has been investigated in various cancers. In our previous study, we found that lobaplatin induced apoptosis and cell cycle arrest via downregulation of proteins including hnRNP A2/B1 in cervical cancer cells. However, the underlying relationship between hnRNP A2/B1 and cervical cancer remained largely unknown. hnRNP A2/B1 knock‑down in HeLa and CaSki cells was performed by shRNA transfection...
January 5, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29327442/transplantation-or-rurality-migration-and-hiv-risk-among-chinese-men-who-have-sex-with-men-in-the-urban-areas
#3
Chuncheng Liu, Rong Fu, Weiming Tang, Bolin Cao, Stephen W Pan, Chongyi Wei, Joseph D Tucker, M Kumi Smith
INTRODUCTION: Migration of men who have sex with men (MSM) from rural to urban areas is common across low- and middle-income countries and is widely believed to contribute to elevated HIV risk among migrant MSM in urban areas. Little consensus exists on whether their risk is due to their transplantation or their being from resource-constrained rural areas. This study seeks to clarify the relationship between migration and HIV risks by comparing differences in HIV-related risky sexual behaviours and healthcare utilization across competing conceptualizations of migratory statuses...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29325569/the-relevance-of-clinical-ethnography-reflections-on-10%C3%A2-years-of-a-cultural-consultation-service
#4
Melissa Dominicé Dao, Sophie Inglin, Sarah Vilpert, Patricia Hudelson
BACKGROUND: Training health professionals in culturally sensitive medical interviewing has been widely promoted as a strategy for improving intercultural communication and for helping clinicians to consider patients' social and cultural contexts and improve patient outcomes. Clinical ethnography encourages clinicians to explore the patient's explanatory model of illness, recourse to traditional and alternative healing practices, healthcare expectations and social context, and to use this information to negotiate a mutually acceptable treatment plan...
January 11, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29325025/towards-an-understanding-of-resilience-responding-to-health-systems-shocks
#5
Johanna Hanefeld, Susannah Mayhew, Helena Legido-Quigley, Frederick Martineau, Marina Karanikolos, Karl Blanchet, Marco Liverani, Esther Yei Mokuwa, Gillian McKay, Dina Balabanova
The recent outbreak of Ebola Virus Disease (EVD) in West Africa has drawn attention to the role and responsiveness of health systems in the face of shock. It brought into sharp focus the idea that health systems need not only to be stronger but also more 'resilient'. In this article, we argue that responding to shocks is an important aspect of resilience, examining the health system behaviour in the face of four types of contemporary shocks: the financial crisis in Europe from 2008 onwards; climate change disasters; the EVD outbreak in West Africa 2013-16; and the recent refugee and migration crisis in Europe...
January 9, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29320740/plexina2-forward-signaling-through-rap1-gtpases-regulates-dentate-gyrus-development-and-schizophrenia-like-behaviors
#6
Xiao-Feng Zhao, Rafi Kohen, Rachel Parent, Yuntao Duan, Grace L Fisher, Matthew J Korn, Lingchao Ji, Guoqiang Wan, Jing Jin, Andreas W Püschel, David F Dolan, Jack M Parent, Gabriel Corfas, Geoffrey G Murphy, Roman J Giger
Dentate gyrus (DG) development requires specification of granule cell (GC) progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial DG. We identify the Plexin family members Plxna2 and Plxna4 as important regulators of DG development. Distribution of immature GCs is regulated by Sema5A signaling through PlxnA2 and requires a functional PlxnA2 GTPase-activating protein (GAP) domain and Rap1 small GTPases. In adult Plxna2-/- but not Plxna2-GAP-deficient mice, the dentate GC layer is severely malformed, neurogenesis is compromised, and mossy fibers form aberrant synaptic boutons within CA3...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29320640/syme-amputation-a-systematic-review
#7
Rudwina Braaksma, Pieter U Dijkstra, Jan H B Geertzen
BACKGROUND: In the decision-making process toward an amputation of the lower extremity, knowledge about patient-related outcomes after amputation and rehabilitation is important. We have not found a systematic review that provides this knowledge for Syme amputation. The aim of this study was to present an overview of outcomes after a Syme amputation grouped according to the International Classification of Functioning, Disability and Health (ICF) model, focusing on body structures and functions, activities, and participation...
January 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29319160/macrophage-plasticity-polarization-and-function-in-health-and-disease
#8
REVIEW
Abbas Shapouri Moghaddam, Saeed Mohammadian, Hossein Vazini, Mahdi Taghadosi, Seyed-Alireza Esmaeili, Fatemeh Mardani, Bita Seifi, Asadollah Mohammadi, Jalil Tavakol Afshari, Amirhossein Sahebkar
Macrophages are heterogeneous and their phenotype and functions are regulated by the surrounding micro-environment. Macrophages commonly exist in two distinct subsets: 1) Classically activated or M1 macrophages, which are pro-inflammatory and polarized by lipopolysaccharide (LPS) either alone or in association with Th1 cytokines such as IFN-γ, GM-CSF and produce pro-inflammatory cytokines such as interleukin-1β (IL-1β), IL-6, IL-12, IL-23 and TNF-α, and 2) Alternatively activated or M2 macrophages, which are anti-inflammatory and immunoregulatory and polarized by Th2 cytokines such as IL-4 and IL-13 and produce anti-inflammatory cytokines such as IL-10 and TGF-β...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29318884/inhibition-of-epithelial-mesenchymal-transition-and-tissue-regeneration-by-waterborne-titanium-dioxide-nanoparticles
#9
Xiaojiao Li, Lele Song, Xingjie Hu, Chang Liu, Jiye Shi, Hui Wang, Lixing Zhan, Haiyun Song
Titanium dioxide nanoparticles (TiO2NPs) are among the most widely manufactured nanomaterials with broad applications in food industry, cosmetics and medicine. Whereas the toxicity of TiO2NPs at high doses has been extensively explored, potential health risks of TiO2NPs exposure at non-toxic concentrations remain poorly understood. Epithelial-mesenchymal transition (EMT) plays pivotal roles in a diversity of physiological and pathological processes including tissue regeneration and cancer metastasis. In this study, we find that cellular uptake of TiO2NPs inhibits EMT-mediated cell remodeling and cell migration without exhibiting cytotoxicity...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29317533/the-social-genome-of-friends-and-schoolmates-in-the-national-longitudinal-study-of-adolescent-to-adult-health
#10
Benjamin W Domingue, Daniel W Belsky, Jason M Fletcher, Dalton Conley, Jason D Boardman, Kathleen Mullan Harris
Humans tend to form social relationships with others who resemble them. Whether this sorting of like with like arises from historical patterns of migration, meso-level social structures in modern society, or individual-level selection of similar peers remains unsettled. Recent research has evaluated the possibility that unobserved genotypes may play an important role in the creation of homophilous relationships. We extend this work by using data from 5,500 adolescents from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine genetic similarities among pairs of friends...
January 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29315980/probiotics-or-pro-healers-the-role-of-beneficial-bacteria-in-tissue-repair
#11
Jovanka Lukic, Vivien Chen, Ivana Strahinic, Jelena Begovic, Hadar Lev-Tov, Stephen C Davis, Marjana Tomic-Canic, Irena Pastar
Probiotics are beneficial microorganisms, known to exert numerous positive effects on human health, primarily in the battle against pathogens. Probiotics have been associated with improved healing of intestinal ulcers, and healing of infected cutaneous wounds. This manuscript reviews the latest findings on probiotics related to their pro-healing properties on gut epithelium and skin. Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts and epithelial cells' migration and function...
January 8, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29315860/nanoparticle-cell-interaction-a-cell-mechanics-perspective
#12
REVIEW
Dedy Septiadi, Federica Crippa, Thomas Lee Moore, Barbara Rothen-Rutishauser, Alke Petri-Fink
Progress in the field of nanoparticles has enabled the rapid development of multiple products and technologies; however, some nanoparticles can pose both a threat to the environment and human health. To enable their safe implementation, a comprehensive knowledge of nanoparticles and their biological interactions is needed. In vitro and in vivo toxicity tests have been considered the gold standard to evaluate nanoparticle safety, but it is becoming necessary to understand the impact of nanosystems on cell mechanics...
January 9, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29308532/violence-against-african-migrant-women-living-in-turin-clinical-and-forensic-evaluation
#13
Paola Castagna, Rossana Ricciardelli, Federica Piazza, Grazia Mattutino, Beatrice Pattarino, Antonella Canavese, Sarah Gino
The phenomenon of migration is often related to violence and exploitation. Data collection in conflict-affected countries is hard and complicated by the lack of literature, especially on the health of migrant female victims of violence. The aim of our study has been to realise a clinical and forensic evaluation on African female migrant's global health through their admissions to the Rape Centre "Soccorso Violenza Sessuale" at Sant'Anna Hospital in Turin. In our sample, we considered several aspects such as place where the violence occurred, number and the identity of the perpetrators, use of physical restraint instruments and/or substances, kidnapping, prostitution under duress, abuses, pregnancies and outcomes, injuries and complained symptoms, female genital mutilation, and sexually transmitted diseases...
January 8, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29307531/easy-to-use-procedure-to-optimise-a-chromatographic-method-application-in-the-determination-of-bisphenol-a-and-phenol-in-toys-by-means-of-liquid-chromatography-with-fluorescence-detection
#14
M M Arce, S Sanllorente, M C Ortiz, L A Sarabia
Legal limits for phenol and bisphenol-A (BPA) in toys are 15 and 0.1 mg L-1 respectively. The latest studies show that in Europe the content of BPA, which reaches our bodies through different contact routes, in no cases exceed legal limits. But it is true that the effects caused by continued intake of this analyte for a long time and other possible processes that could increase their migration, are still under consideration by the health agencies responsible. A multiresponse optimization using a D-optimal design for simultaneously optimising two experimental factors (temperature and flow) at three levels and one (mobile phase composition) at four levels, in the determination by means of HPLC-FLD is proposed in this work...
December 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29307383/prevalence-and-circumstances-of-forced-sex-and-post-migration-hiv-acquisition-in-sub-saharan-african-migrant-women-in-france-an-analysis-of-the-anrs-parcours-retrospective-population-based-study
#15
Julie Pannetier, Andrainolo Ravalihasy, Nathalie Lydié, France Lert, Annabel Desgrées du Loû
BACKGROUND: Sub-Saharan African migrant women are a key population at risk of HIV infection in Europe. Using data from the ANRS-PARCOURS study, we aimed to assess the prevalence of forced sex after migration and its association with post-migration acquisition of HIV as well as the circumstances of forced sex after migration, including housing and administrative insecurity, among sub-Saharan African migrant women living in the Paris Region, France. METHODS: The ANRS-PARCOURS study was a retrospective life-event survey done between February, 2012, and May, 2013, in health-care facilities in the Paris region of France...
January 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29307266/differences-in-participation-rates-between-urban-and-rural-areas-are-diminishing-in-finland
#16
Hanna Tolonen, Päivikki Koponen, Katja Borodulin, Satu Männistö, Markku Peltonen, Erkki Vartiainen
Increasing within-country migration from rural to urban areas is setting new challenges for survey organization. For example, the educational level of population in urban and rural areas differ, resulting in differences in health behaviours and health outcomes between areas. Data from the national cross-sectional surveys of the FINRISK Study conducted in Finland in 1997-2012 among the adult population were used. Women living in the capital region were more likely to be survey non-participants than women living in rural areas...
January 1, 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29307265/epigenetic-control-of-schwann-cells
#17
Ki H Ma, John Svaren
The journey of Schwann cells from their origin in the neural crest to their ensheathment and myelination of peripheral nerves is a remarkable one. Their apparent static function in enabling saltatory conduction of mature nerve is not only vital for long-term health of peripheral nerve but also belies an innate capacity of terminally differentiated Schwann cells to radically alter their differentiation status in the face of nerve injury. The transition from migrating neural crest cells to nerve ensheathment, and then myelination of large diameter axons has been characterized extensively and several of the transcriptional networks have been identified...
January 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29304180/the-effect-of-facility-characteristics-on-patient-safety-patient-experience-and-service-availability-for-procedures-in-non-hospital-affiliated-outpatient-settings-a-systematic-review
#18
Nancy F Berglas, Molly F Battistelli, Wanda K Nicholson, Mindy Sobota, Richard D Urman, Sarah C M Roberts
BACKGROUND: Over recent decades, numerous medical procedures have migrated out of hospitals and into freestanding ambulatory surgery centers (ASCs) and physician offices, with possible implications for patient outcomes. In response, states have passed regulations for office-based surgeries, private organizations have established standards for facility accreditation, and professional associations have developed clinical guidelines. While abortions have been performed in office setting for decades, states have also enacted laws requiring that facilities that perform abortions meet specific requirements...
2018: PloS One
https://www.readbyqxmd.com/read/29304164/influence-of-peer-support-on-hiv-sti-prevention-and-safety-amongst-international-migrant-sex-workers-a-qualitative-study-at-the-mexico-guatemala-border
#19
Belen Febres-Cordero, Kimberly C Brouwer, Teresita Rocha-Jimenez, Carmen Fernandez-Casanueva, Sonia Morales-Miranda, Shira M Goldenberg
BACKGROUND: Migrant women engaged in precarious employment, such as sex work, frequently face pronounced social isolation alongside other barriers to health and human rights. Although peer support has been identified as a critical HIV and violence prevention intervention for sex workers, little is known about access to peer support or its role in shaping health and social outcomes for migrant sex workers. This article analyses the role of peer support in shaping vulnerability and resilience related to HIV/STI prevention and violence among international migrant sex workers at the Mexico-Guatemala border...
2018: PloS One
https://www.readbyqxmd.com/read/29302163/inconvenient-human-rights-water-and-sanitation-in-sweden-s-informal-roma-settlements
#20
Martha F Davis, Natasha Ryan
Following an increase in Roma migration under the European "freedom of movement" laws, Swedish municipalities initiated more than 80 evictions of informal Roma settlements on the grounds of poor sanitation between 2013 and 2016. These evictions echo policies from earlier in the 20th century, when Roma living in Sweden were often marginalized through the denial of access to water and sanitation facilities. The recent Swedish evictions also follow similar government actions across Europe, where Roma settlements are controlled through the denial of access to water and sanitation...
December 2017: Health and Human Rights
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