Jianing Fu, Weiwei Liu, Siyu Liu, Ruxiao Zhao, Toshihiko Hayashi, Haina Zhao, Yinlanqi Xiang, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima
Breast cancer is one of the most common cancers threatening women's health. Our previous study found that silibinin induced the death of MCF-7 and MDA-MB-231 human breast cancer cells. We noticed that silibinin-induced cell damage was accompanied by morphological changes, including the increased cell aspect ratio (cell length/width) and decreased cell area. Besides, the cytoskeleton is also destroyed in cells treated with silibinin. YAP/TAZ, a mechanical signal sensor interacted with extracellular pressure, cell adhesion area and cytoskeleton, is also closely associated with cell survival, proliferation and migration...
April 19, 2024: Cellular Signalling