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"Tendinopathy"

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https://www.readbyqxmd.com/read/29037195/comparison-between-xcelligence-biosensor-technology-and-conventional-cell-culture-system-for-real-time-monitoring-human-tenocytes-proliferation-and-drugs-cytotoxicity-screening
#1
Chih-Hao Chiu, Kin Fong Lei, Wen-Ling Yeh, Poyu Chen, Yi-Sheng Chan, Kuo-Yao Hsu, Alvin Chao-Yu Chen
BACKGROUND: Local injections of anesthetics, NSAIDs, and corticosteroids for tendinopathies are empirically used. They are believed to have some cytotoxicity toward tenocytes. The maximal efficacy dosages of local injections should be determined. A commercial 2D microfluidic xCELLigence system had been developed to detect real-time cellular proliferation and their responses to different stimuli and had been used in several biomedical applications. The purpose of this study is to determine if human tenocytes can successfully proliferate inside xCELLigence system and the result has high correlation with conventional cell culture methods in the same condition...
October 16, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29035982/comparison-of-the-effect-of-5-different-treatment-options-for-managing-patellar-tendinopathy-a-secondary-analysis
#2
Dafne van Rijn, Inge van den Akker-Scheek, Mirjam Steunebrink, Ron L Diercks, Johannes Zwerver, Henk van der Worp
OBJECTIVE: Currently, no treatments exist for patellar tendinopathy (PT) that guarantee quick and full recovery. Our objective was to assess which treatment option provides the best chance of clinical improvement and to assess the influence of patient and injury characteristics on the clinical effect of these treatments. DESIGN: A secondary analysis was performed on the combined databases of 3 previously performed double-blind randomized controlled trials. PATIENTS: In total, 138 patients with PT were included in the analysis...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29024514/therapeutic-potential-of-haecs-for-early-achilles-tendon-defect-repair-through-regeneration
#3
Barbara Barboni, Valentina Russo, Valentina Gatta, Nicola Bernabò, Paolo Berardinelli, Annunziata Mauro, Alessandra Martelli, Luca Valbonetti, Aurelio Muttini, Oriana Di Giacinto, Maura Turriani, Antonietta Silini, Giuseppe Calabrese, Michele Abate, Ornella Parolini, Liborio Stuppia, Mauro Mattioli
Cell-based therapy hold great promise for tendon disorders, a widespread debilitating musculoskeletal condition. Even if the cell line remains to be defined, preliminary evidences have proven that amniotic-derived cells possess in vitro and in vivo a great tenogenic potential. The present study investigated the efficacy of transplanted human amniotic epithelial cells (hAECs) by testing their early regenerative properties and mechanisms involved on a validated ovine Achilles tendon partial defect performed on 29 animals...
October 11, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29023489/spatiotemporal-variations-in-gene-expression-histology-and-biomechanics-in-an-ovine-model-of-tendinopathy
#4
Sara Biasutti, Andrew Dart, Margaret Smith, Carina Blaker, Elizabeth Clarke, Leo Jeffcott, Christopher Little
Flexor tendinopathy is a common problem affecting humans and animals. Tendon healing is poorly understood and the outcomes of conservative and surgical management are often suboptimal. While often considered a localized injury, recent evidence indicates that in the short term, tendinopathic changes are distributed widely throughout the tendon, remote from the lesion itself. Whether these changes persist throughout healing is unknown. The aim of this study was to document gene expression, histopathological and biomechanical changes that occur throughout the superficial digital flexor tendon (SDFT) up to 16 weeks post-injury, using an ovine surgical model of tendinopathy...
2017: PloS One
https://www.readbyqxmd.com/read/29023220/photobiomodulation-for-achilles-tendinopathy
#5
O Sahap Atik
No abstract text is available yet for this article.
October 12, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29021905/the-waterpolo-shoulder-paradigm-results-of-ultrasound-surveillance-at-poolside
#6
Felice Galluccio, Eleonora Bellucci, Francesco Porta, Lorenzo Tofani, Amato De Paulis, Diana Bianchedi, Tatiana Barskova, Marco Matucci-Cerinic
BACKGROUND: Waterpolo consists of a combination of swimming and throwing with close contact between players. The shoulder is the most frequently injured joint, with a combination of rotator cuff tear and tendinopathy, long head biceps tendinopathy, superior labral lesions and shoulder impingement. This unique combination is a challenge for the clinician who must determine which of these shoulder pathologies is responsible for the onset of pain and the best strategy to rehabilitate the joint and prevent recurrence...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28993403/cognitive-and-contextual-factors-to-optimise-clinical-outcomes-in-tendinopathy
#7
EDITORIAL
Adrian James Mallows, James Robert Debenham, Peter Malliaras, Richmond Stace, Chris Littlewood
No abstract text is available yet for this article.
October 9, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28992843/-extracorporeal-shock-wave-therapy-in-chronic-achilles-tendinopathy
#8
EDITORIAL
Lotte Hasselbalch, Per Hölmich
Extracorporeal shock wave therapy (ESWT) has shown promising results in treating epicondylitis lateralis humeri and fasciitis plantaris. This study investigates whether the evidence supports ESWT as part of the conservative treatment regime of chronic Achilles tendinopathy. The differences in diagnosing chronic Achilles tendinopathy, the use of different ESWT-machines and the difference in the evaluating methods for pain make it difficult to compare the studies. There is, however, a clear tendency toward ESWT having a positive treatment effect on chronic Achilles tendinopathy at both the insertion and the mid-portion...
October 2, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28990575/a-systematic-review-of-the-concept-and-clinical-applications-of-bone-marrow-aspirate-concentrate-in-tendon-pathology
#9
Mohamed A Imam, James Holton, Saman Horriat, Ahmed S Negida, Florian Grubhofer, Rohit Gupta, Ali Narvani, Martyn Snow
Tendon pathologies are a group of musculoskeletal conditions frequently seen in clinical practice. They can be broadly classified into traumatic, degenerative and overuse-related tendinopathies. Rotator cuff tears, Achilles tendinopathy and tennis elbow are common examples of these conditions. Conventional treatments have shown inconsistent outcomes and might fail to provide satisfactory clinical improvement. With the growing trend towards the use of mesenchymal stem cells (MSCs) in other branches of medicine, there is an increasing interest in treating tendon pathologies using the bone marrow MSC...
2017: SICOT-J
https://www.readbyqxmd.com/read/28990574/an-evidence-based-evaluation-on-the-use-of-platelet-rich-plasma-in-orthopedics-a-review-of-the-literature
#10
Nasir Hussain, Herman Johal, Mohit Bhandari
Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed...
2017: SICOT-J
https://www.readbyqxmd.com/read/28987658/magnetic-resonance-and-ultrasound-in-achilles-tendinopathy-predictive-role-and-response-assessment-to-platelet-rich-plasma-and-adipose-derived-stromal-vascular-fraction-injection
#11
Domenico Albano, Carmelo Messina, Federico Giuseppe Usuelli, Laura De Girolamo, Miriam Grassi, Camilla Maccario, Bianca Bignotti, Alberto Tagliafico, Luca Maria Sconfienza
OBJECTIVE: To assess the correlation between magnetic resonance and ultrasound findings and clinical outcome after intratendinous injection of leucocyte-rich platelet-rich plasma or adipose-derived stromal vascular fraction in patients with non-insertional Achilles tendinopathy. MATERIALS AND METHODS: Forty-three patients (age: 47.8±5.1, range 29-55) with unilateral or bilateral non-insertional Achilles tendinopathy (58 tendons overall) were randomly assigned to platelet-rich plasma (22 patients, 28 tendons) or adipose-derived stromal vascular fraction (21 patients, 30 tendons) injection group...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28985641/a-genetic-marker-associated-with-de-quervain-s-tenosynovitis
#12
Stuart K Kim, Marwa A Ahmed, Andy L Avins, John P A Ioannidis
De Quervain's tenosynovitis is a repetitive strain injury involving synovial inflammation of the tendons of the first extensor compartment of the wrist. It is relatively common in the general population, and is the most common radial-sided tendinopathy seen in athletes. Identifying a genetic marker associated with de Quervain's tenosynovitis could provide a useful tool to help identify those individuals with an increased risk for injury. A genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health (RPGEH) including 4,129 cases and 98,374 controls...
October 6, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28980027/-insertional-achilles-tendinopathy-differentiated-diagnostics-and-therapy
#13
REVIEW
S F Baumbach, M Braunstein, M G Mack, F Maßen, W Böcker, S Polzer, H Polzer
Achilles tendinopathy at the calcaneal insertion is classified into insertional tendinopathy, retrocalcaneal and superficial bursitis. The aim of this study was to present the current evidence on conservative and surgical treatment of insertional tendinopathy of the Achilles tendon. Conservative first-line therapy includes reduction of activity levels, administration of non-steroidal anti-inflammatory drugs (NSAID), adaptation of footwear, heel wedges and orthoses or immobilization. In addition, further conservative therapy options are also available...
October 4, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28979585/posterior-tibial-tendon-dysfunction-an-overview
#14
Samuel Ka-Kin Ling, Tun Hing Lui
BACKGROUND: Adult acquired flatfoot deformity is a commonly seen condition with a large clinical spectrum. It ranges from asymptomatic subjects to severely disabled arthritic patients. Posterior tibialis tendon dysfunction is a common cause of adult acquired flatfoot deformity. METHODS: This article systematically reviews the published literature from books and journals that were either originally written or later translated into the English language regarding the subject of posterior tibialis tendon dysfunction...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28972291/achilles-and-patellar-tendinopathy-display-opposite-changes-in-elastic-properties-a-shear-wave-elastography-study
#15
Brooke Kaye Coombes, Kylie Tucker, Bill Vicenzino, Viana Vuvan, Rebecca Mellor, Luke Heales, Antoine Nordez, François Hug
PURPOSE: To compare tendon elastic and structural properties of healthy individuals with those with Achilles or patellar tendinopathy. METHODS: Sixty-seven participants (22 Achilles tendinopathy, 17 patellar tendinopathy, 28 healthy controls) were recruited between March 2015-March 2016. Shear wave velocity (SWV), an index of tissue elastic modulus, and tendon thickness were measured bilaterally at mid-tendon and insertional regions of Achilles and patellar tendons by an examiner blinded to group...
October 3, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28966374/current-concepts-in-the-diagnosis-and-treatment-of-shoulder-impingement
#16
Bijayendra Singh, Nik Bakti, Abhinav Gulihar
Subacromial impingement syndrome (SIS) is a very common cause of shoulder pain in the young adults. It can cause debilitating pain, dysfunction, and affects the activities of daily living. It represents a spectrum of pathology ranging from bursitis to rotator cuff tendinopathy which can ultimately lead to degenerative tear of the rotator cuff. Various theories and concepts have been described and it is still a matter of debate. However, most published studies suggest that both extrinsic and intrinsic factors have a role in the development of SIS...
September 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28954794/the-effectiveness-of-extracorporeal-shockwave-therapy-in-common-lower-limb-conditions-a-systematic-review-including-quantification-of-patient-rated-pain-reduction
#17
REVIEW
Vasileios Korakakis, Rodney Whiteley, Alexander Tzavara, Nikolaos Malliaropoulos
OBJECTIVE: To evaluate extracorporeal shockwave therapy (ESWT) in treating Achilles tendinopathy (AT), greater trochanteric pain syndrome (GTPS), medial tibial stress syndrome (MTSS), patellar tendinopathy (PT) and proximal hamstring tendinopathy (PHT). DESIGN: Systematic review. ELIGIBILITY CRITERIA: Randomised and non-randomised studies assessing ESWT in patients with AT, GTPS, MTSS, PT and PHT were included. Risk of bias and quality of studies were evaluated...
September 27, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28952802/novel-tenascin-c-haplotype-modifies-the-risk-for-a-failure-to-heal-after-rotator-cuff-repair
#18
Rainer Kluger, Klaus R Huber, Philipp G Seely, Christian E Berger, Florian Frommlet
BACKGROUND: Several single-nucleotide polymorphisms (SNPs) in the TNC gene have recently been found to be associated with degenerative rotator cuff tears. HYPOTHESIS: Exonic SNPs in the TNC gene are related to the risk for a failure to heal after rotator cuff repair. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: A total of 302 patients from the Vienna area and European Caucasian ancestry underwent mini-open rotator cuff repair for a full-thickness superior or posterosuperior tear and were assessed for the integrity of the repair 1 year postoperatively with a real-time 7...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28948634/applying-physical-science-principles-to-mid-substance-achilles-tendinopathy-and-the-relationship-to-eccentric-lengthening-exercises
#19
Geoffrey M Verrall, Bronwyn K Dolman, Thomas Best
OBJECTIVES: Mid-substance Achilles tendinopathy is common in the active population. Eccentric (lengthening) exercises are known to be effective in alleviating the clinical condition. To better understand mid-substance Achilles tendinopathy and the response to lengthening exercises physical science principles of elasticity are applied. METHOD: We apply elastic motion laws to the spring-like tendon as well as the normal and pathological adaptation seen with this common injury...
September 26, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28947893/targeting-inflammation-in-rotator-cuff-tendon-degeneration-and-repair
#20
Adam C Abraham, Shivam A Shah, Stavros Thomopoulos
Rotator cuff degeneration is a common affliction that results in pain and disability. Tendinopathy was historically classified with or without the involvement of the immune system. However, technological advancements in screening have shown that the immune system is both present and active in all forms of tendinopathy. During injury and healing, the coordinated effort of numerous immune cell populations work with the resident stromal cells to break down damaged tissues and stimulate remodeling. These cells deploy a wide array of tools, including phagocytosis, enzyme secretion, and chemotactic gradients to direct these processes...
September 2017: Techniques in Shoulder & Elbow Surgery
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