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https://www.readbyqxmd.com/read/29353418/emerging-trends-in-hospitalisation-for-fragility-fractures-in-ireland
#1
M A Kelly, B McGowan, M J McKenna, K Bennett, J J Carey, B Whelan, C Silke
BACKGROUND: We analysed hospital admissions and bed occupancy for fragility fractures in Ireland over a 15-year period to assess fracture admission trends and to project admissions over the next three decades. METHODS: We used the Hospital In-Patient Enquiry (HIPE) scheme to extract data on fracture admissions to Irish hospitals between 2000 and 2014 inclusive. We calculated absolute numbers and age-standardised rates of hospitalisations for men and women ≥ 50 years for each osteoporotic-type fracture...
January 20, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29353407/role-of-the-petrous-ridge-and-angulation-of-the-trigeminal-nerve-in-the-pathogenesis-of-trigeminal-neuralgia-with-implications-for-microvascular-decompression
#2
Andrei Brinzeu, Chloé Dumot, Marc Sindou
INTRODUCTION: Vascular compression is the main pathogenetic factor in apparently primary trigeminal neuralgia; however some patients may present with clinically classical neuralgia but no vascular conflict on MRI or even at surgery. Several factors have been cited as alternative or supplementary factors that may cause neuralgia. This work focuses on the shape of the petrous ridge at the point of exit from the cavum trigeminus as well as the angulation of the nerve at this point. METHODS: Patients with trigeminal neuralgia that had performed a complete imagery workup according to our protocol and had microvascular decompression were included as well as ten controls...
January 20, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29353323/does-methylphenidate-improve-academic-performance-a-systematic-review-and-meta-analysis
#3
REVIEW
Anne Fleur Kortekaas-Rijlaarsdam, Marjolein Luman, Edmund Sonuga-Barke, Jaap Oosterlaan
Academic improvement is amongst the most common treatment targets when prescribing stimulants to children with ADHD. Previous reviews on stimulant-related academic improvements are inconclusive and focus on task engagement. Recent literature suggests outcome-domain-specific medication effects that are larger for productivity than for accuracy. The aims of this study are quantifying methylphenidate effects on academic productivity and accuracy for math, reading, spelling; exploring the mediating or moderating effects of symptom improvements, demographic-, design- and disorder-related variables...
January 20, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29353289/the-new-agreement-of-the-international-riga-consensus-conference-on-nasal-airway-function-tests
#4
K Vogt, G Bachmann-Harildstad, A Lintermann, A Nechyporenko, F Peters, K D Wernecke
The report reflects an agreement based on the consensus conference of the International Standardization Committee on the Objective Assessment of the Nasal Airway in Riga, 2nd Nov. 2016. The aim of the conference was to address the existing nasal airway function tests and to take into account physical, mathematical and technical correctness as a base of international standardization as well as the requirements of the Council Directive 93/42/EEC of 14 June 1993 concerning medical devices. Rhinomanometry, acoustic rhinometry, peak nasal inspiratory flow, Odiosoft-Rhino, optical rhinometry, 24-h measurements, computational fluid dynamics, nasometry and the mirrow test were evaluated for important diagnostic criteria, which are the precision of the equipment including calibration and the software applied; validity with sensitivity, specificity, positive and negative predictive values, reliability with intra-individual and inter-individual reproducibility and responsiveness in clinical studies...
January 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29353243/impact-of-order-set-design-on-urine-culturing-practices-at-an-academic-medical-centre-emergency-department
#5
Satish Munigala, Ronald R Jackups, Robert F Poirier, Stephen Y Liang, Helen Wood, S Reza Jafarzadeh, David K Warren
BACKGROUND: Urinalysis and urine culture are commonly ordered tests in the emergency department (ED). We evaluated the impact of removal of order sets from the 'frequently ordered test' in the computerised physician order entry system (CPOE) on urine testing practices. METHODS: We conducted a before (1 September to 20 October 2015) and after (21 October to 30 November 2015) study of ED patients. The intervention consisted of retaining 'urinalysis with reflex to microscopy' as the only urine test in a highly accessible list of frequently ordered tests in the CPOE system...
January 20, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29353129/keeping-it-together-and-falling-apart-women-s-dynamic-experience-of-birth
#6
Priscilla J Hall, Jennifer Whitman Foster, Kathryn M Yount, Bonnie Mowinski Jennings
OBJECTIVE: To explore the complexity of women's birth experiences in the context in which they occur and to describe how these influence women's well-being in labor. DESIGN: Qualitative method with a phenomenological approach, following the analysis principles of van Manen. PARTICIPANTS AND SETTING: Eight women from different ethnic and socioeconomic backgrounds in Atlanta, Georgia, United States with a recent, healthy birth were interviewed twice about their experience of the labor journey...
December 14, 2017: Midwifery
https://www.readbyqxmd.com/read/29353127/physical-comorbidities-increase-the-risk-of-psychiatric-comorbidity-in-immune-mediated-inflammatory-disease
#7
Ruth Ann Marrie, Randy Walld, James M Bolton, Jitender Sareen, John R Walker, Scott B Patten, Alexander Singer, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein
OBJECTIVE: We tested the association between physical comorbidity and incident depression, anxiety disorder and bipolar disorder in three immune-mediated inflammatory diseases (IMID): inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA) versus age-, sex- and geographically-matched controls. METHODS: Using population-based administrative data we identified 6119 persons with IBD, 3514 persons with MS, 10,206 persons with RA and 97,727 matched controls...
January 11, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29353125/relationship-between-serum-trimethylamine-n-oxide-and-exposure-to-dioxin-like-pollutants
#8
Michael C Petriello, Richard Charnigo, Manjula Sunkara, Sony Soman, Marian Pavuk, Linda Birnbaum, Andrew J Morris, Bernhard Hennig
Trimethylamine N-oxide (TMAO) is a diet and gut microbiota-derived metabolite that has been linked to cardiovascular disease risk in human studies and animal models. TMAO levels show wide inter and intra individual variability in humans that can likely be accounted for by multiple factors including diet, the gut microbiota, levels of the TMAO generating liver enzyme Flavin-containing monooxygenase 3 (FMO3) and kidney function. We recently found that dioxin-like (DL) environmental pollutants increased FMO3 expression to elevate circulating diet-derived TMAO in mice, suggesting that exposure to this class of pollutants might also contribute to inter-individual variability in circulating TMAO levels in humans...
January 16, 2018: Environmental Research
https://www.readbyqxmd.com/read/29353116/scale-inhibition-and-flocculation-dual-functionality-of-poly-acrylic-acid-grafted-starch
#9
Qing Du, Yawen Wang, Aimin Li, Hu Yang
Natural-polymer based water treatment agents have recently received much more attention due to their environmental friendliness, widespread availability, and prominent structural features. Starch-graft-poly(acrylic acid) (St-g-PAA) is a simple natural-polymer based material that can be obtained easily by a one-step graft copolymerization. When used as a water treatment agent, St-g-PAA exhibits both effective scale-inhibition performance and high turbidity removal efficiency. The scale-inhibition efficiency of St-g-PAA against calcium carbonate (CaCO3) is approximately 94% at the optimal dose in a static test of approximately 40 mg/L...
January 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29353103/taking-the-heat-or-taking-the-temperature-a-qualitative-study-of-a-large-scale-exercise-in-seeking-to-measure-for-improvement-not-blame
#10
Natalie Armstrong, Liz Brewster, Carolyn Tarrant, Ruth Dixon, Janet Willars, Maxine Power, Mary Dixon-Woods
Measurement of quality and safety has an important role in improving healthcare, but is susceptible to unintended consequences. One frequently made argument is that optimising the benefits from measurement requires controlling the risks of blame, but whether it is possible to do this remains unclear. We examined responses to a programme known as the NHS Safety Thermometer (NHS-ST). Measuring four common patient harms in diverse care settings with the goal of supporting local improvement, the programme explicitly eschews a role for blame...
January 2, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29353055/pituitary-adenylate-cyclase-activating-polypeptide-pacap-signaling-in-the-prefrontal-cortex-modulates-cued-fear-learning-but-not-spatial-working-memory-in-female-rats
#11
Adam J Kirry, Matthew R Herbst, Sarah E Poirier, Michelle M Maskeri, Amy C Rothwell, Robert C Twining, Marieke R Gilmartin
A genetic polymorphism within the gene encoding the pituitary adenylate-cyclase activating polypeptide (PACAP) receptor type I (PAC1R) has recently been associated with hyper-reactivity to threat-related cues in women, but not men, with post-traumatic stress disorder (PTSD). PACAP is a highly conserved peptide, whose role in mediating adaptive physiological stress responses is well established. Far less is understood about the contribution of PACAP signaling in emotional learning and memory, particularly the encoding of fear to discrete cues...
January 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29353022/using-medical-examiner-case-narratives-to-improve-opioid-overdose-surveillance
#12
Emily Hurstak, Christopher Rowe, Caitlin Turner, Emily Behar, Rachel Cabugao, Nikolas P Lemos, Phillip Coffin
BACKGROUND: Current opioid overdose mortality surveillance methods do not capture the complexity of the overdose epidemic. Most rely on death certificates, which may underestimate both opioid analgesic and heroin deaths. Categorizing deaths using other characteristics from the death record including route of drug administration may provide useful information to design and evaluate overdose prevention interventions. METHODS: We reviewed California Electronic Death Reporting System records and San Francisco Office of the Chief Medical Examiner (OCME) toxicology reports and investigative case narratives for all unintentional opioid overdose deaths in San Francisco County from 2006 to 2012...
January 17, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29352849/impact-of-vasculitis-on-employment-and-income
#13
Lillian Barra, Renée L Borchin, Cristina Burroughs, George C Casey, Carol A McAlear, Antoine G Sreih, Kalen Young, Peter A Merkel, Christian Pagnoux
OBJECTIVES: Work disability associated with rheumatic diseases accounts for a substantial financial burden. However, few studies have investigated disability among patients with vasculitis. The purpose of this study was to examine the impact of vasculitis on patient employment and income. METHODS: Patients enrolled in the Vasculitis Clinical Research Consortium (VCRC) Patient Contact Registry, living in the USA or Canada, and followed for >1 year post-diagnosis, participated in an online survey-based study...
January 10, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352829/the-who-recommendation-of-home-fortification-of-foods-with-multiple-micronutrient-powders-in-children-under-2-years-of-age-and-its-effectiveness-on-anaemia-and-weight-a-pragmatic-cluster-randomized-controlled-trial
#14
Yassinmè Elysée Somassè, Michèle Dramaix, Boncana Traoré, Ildephonse Ngabonziza, Ousmane Touré, Mamadou Konaté, Mamadou Diallo, Philippe Donnen
OBJECTIVE: To assess under real community settings the effectiveness of the WHO strategy of home fortification of foods (HFF) with multiple-micronutrient powders on Hb change, anaemia and weight in children. DESIGN: A pragmatic cluster-randomized controlled trial. SETTING: Forty villages in the Nioro Circle in Mali and 722 children aged 6-23 months were randomized to the intervention or control group. The intervention consisted of a daily dose of multiple-micronutrient powder for 3 months; in the control group, no supplement was given...
January 21, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29352787/communication-exact-analytical-derivatives-for-the-domain-based-local-pair-natural-orbital-mp2-method-dlpno-mp2
#15
Peter Pinski, Frank Neese
Electron correlation methods based on pair natural orbitals (PNOs) have gained an increasing degree of interest in recent years, as they permit energy calculations to be performed on systems containing up to many hundred atoms, while maintaining chemical accuracy for reaction energies. We present an approach for taking exact analytical first derivatives of the energy contributions in the simplest method of the family of Domain-based Local Pair Natural Orbital (DLPNO) methods, closed-shell DLPNO-MP2. The Lagrangian function contains constraints to account for the relaxation of PNOs...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352773/ultra-fast-relaxation-decoherence-and-localization-of-photoexcited-states-in-%C3%AF-conjugated-polymers
#16
Jonathan R Mannouch, William Barford, Sarah Al-Assam
The exciton relaxation dynamics of photoexcited electronic states in poly(p-phenylenevinylene) are theoretically investigated within a coarse-grained model, in which both the exciton and nuclear degrees of freedom are treated quantum mechanically. The Frenkel-Holstein Hamiltonian is used to describe the strong exciton-phonon coupling present in the system, while external damping of the internal nuclear degrees of freedom is accounted for by a Lindblad master equation. Numerically, the dynamics are computed using the time evolving block decimation and quantum jump trajectory techniques...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352771/severe-cutaneous-adverse-reactions-due-to-inappropriate-medication-use
#17
G Chaby, L Valeyrie-Allanore, T A Duong, B Lebrun-Vignes, B Milpied, B Sassolas, F Tetart, P Wolkenstein, O Chosidow, L Fardet
BACKGROUD: The proportion of severe cutaneous adverse reactions (SCARs) that could be avoided if medication use was consistent with good medical practice is unknown. OBJECTIVES: To estimate the proportion of SCARs related to inappropriate medication use. METHODS: Retrospective study of all validated SCARs collected in a French registry between 2003 and 2016. For each case, all plausible drugs suspected to induce SCARs (i.e., not just the drug regarded as "the most probable") were considered regarding three causes of preventability: (1) prescription for an inappropriate indication, (2) unintentional rechallenge despite a previous allergy to the drug, or (3) self-medication with prescription medicines...
January 20, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29352626/differences-between-sexes-in-the-standard-and-advanced-dimensioning-of-lateral-meniscal-allografts
#18
Patrycja Mickiewicz, Michał Walczak, Michał Łaszczyca, Damian Kusz, Zygmunt Wróbel
BACKGROUND: There are many different methods of meniscal allograft measurements, which depend on individual tissue bank procedures. Due to the lack of a standardised method of dimensioning, measurement results may vary between individual cases. Consequently, allograft may be mismatched to the patient's knee anatomy. The purpose of this study was to measure four meniscal dimensions - two standard and two specific - and then compare them between sexes. METHODS: Fourteen cadaveric lateral menisci (seven male and seven female) were scanned using a microtomography scanner...
January 15, 2018: Knee
https://www.readbyqxmd.com/read/29352616/assessing-advanced-airway-management-performance-in-a-national-cohort-of-emergency-medical-services-agencies
#19
Henry E Wang, John P Donnelly, Dustin Barton, Jeffrey L Jarvis
STUDY OBJECTIVE: Although often the focus of quality improvement efforts, emergency medical services (EMS) advanced airway management performance has few national comparisons, nor are there many assessments with benchmarks accounting for differences in agency volume or patient mix. We seek to assess variations in advanced airway management and conventional intubation performance in a national cohort of EMS agencies. METHODS: We used EMS data from ESO Solutions, a national EMS electronic health record system...
January 15, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29352607/integrated-lung-tissue-mechanics-one-piece-at-a-time-computational-modeling-across-the-scales-of-biology
#20
REVIEW
Kelly S Burrowes, Amin Iravani, Wendy Kang
The lung is a delicately balanced and highly integrated mechanical system. Lung tissue is continuously exposed to the environment via the air we breathe, making it susceptible to damage. As a consequence, respiratory diseases present a huge burden on society and their prevalence continues to rise. Emergent function is produced not only by the sum of the function of its individual components but also by the complex feedback and interactions occurring across the biological scales - from genes to proteins, cells, tissue and whole organ - and back again...
January 12, 2018: Clinical Biomechanics
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