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https://www.readbyqxmd.com/read/29356183/whole-brain-white-matter-histogram-analysis-of-diffusion-tensor-imaging-data-detects-microstructural-damage-in-mild-cognitive-impairment-and-alzheimer-s-disease-patients
#1
Giovanni Giulietti, Mario Torso, Laura Serra, Barbara Spanò, Camillo Marra, Carlo Caltagirone, Mara Cercignani, Marco Bozzali
BACKGROUND: Amnestic mild cognitive impairment (MCI) is a transitional stage between normal aging and Alzheimer's disease (AD). However, the clinical conversion from MCI to AD is unpredictable. Hence, identification of noninvasive biomarkers able to detect early changes induced by dementia is a pressing need. PURPOSE: To explore the added value of histogram analysis applied to measures derived from diffusion tensor imaging (DTI) for detecting brain tissue differences between AD, MCI, and healthy subjects (HS)...
January 21, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29356032/non-invasive-quantitative-assessment-of-liver-fat-by-mri-pdff-as-an-endpoint-in-nash-trials
#2
REVIEW
Cyrielle Caussy, Scott B Reeder, Claude B Sirlin, Rohit Loomba
Nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease worldwide, and the progressive form of this condition, nonalcoholic steatohepatitis (NASH), has become one of the leading indications for liver transplant. Despite intensive investigations, there are currently no FDA approved therapies for treating NASH. A major barrier for drug development in NASH is that treatment response assessment continues to require liver biopsy, which is invasive and interpreted subjectively...
January 21, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29355981/examination-of-the-skin-barrier-repair-wound-healing-process-using-a-living-skin-equivalent-lse-model-and-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging-maldi-msi
#3
E E L Lewis, M R T Barrett, L Freeman-Parry, R A Bojar, M R Clench
OBJECTIVE: Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to identify lipids directly involved as potential biomarkers. These biomarkers may be used to determine whether an in vivo wound is going to heal for example if infected. METHODS: An in vitro LSE model was wounded with a scalpel blade and assessed at day 4 post wounding by histology and MALDI-MSI...
January 21, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29354484/shortness-of-breath-in-clinical-practice-a-case-for-left-atrial-function-and-exercise-stress-testing-for-a-comprehensive-diastolic-heart-failure-workup
#4
REVIEW
Pupalan Iyngkaran, Nagesh S Anavekar, Christopher Neil, Liza Thomas, David L Hare
The symptom cluster of shortness of breath (SOB) contributes significantly to the outpatient workload of cardiology services. The workup of these patients includes blood chemistry and biomarkers, imaging and functional testing of the heart and lungs. A diagnosis of diastolic heart failure is inferred through the exclusion of systolic abnormalities, a normal pulmonary function test and normal hemoglobin, coupled with diastolic abnormalities on echocardiography. Differentiating confounders such as obesity or deconditioning in a patient with diastolic abnormalities is difficult...
December 26, 2017: World Journal of Methodology
https://www.readbyqxmd.com/read/29354214/a-panel-of-clinical-and-neuropathological-features-of-cerebrovascular-disease-through-the-novel-neuroimaging-methods
#5
Gilberto Sousa Alves, Luiza de Amorim de Carvalho, Felipe Kenji Sudo, Lucas Briand, Jerson Laks, Eliasz Engelhardt
The last decade has witnessed substantial progress in acquiring diagnostic biomarkers for the diagnostic workup of cerebrovascular disease (CVD). Advanced neuroimaging methods not only provide a strategic contribution for the differential diagnosis of vascular dementia (VaD) and vascular cognitive impairment (VCI), but also help elucidate the pathophysiological mechanisms ultimately leading to small vessel disease (SVD) throughout its course. Objective: In this review, the novel imaging methods, both structural and metabolic, were summarized and their impact on the diagnostic workup of age-related CVD was analysed...
October 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29354004/magnetic-resonance-image-texture-analysis-of-the-periaqueductal-gray-matter-in-episodic-migraine-patients-without-t2-visible-lesions
#6
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Shengyuan Yu, Lin Ma
Objective: The periaqueductal gray matter (PAG), a small midbrain structure, presents dysfunction in migraine. However, the precise neurological mechanism is still not well understood. Herein, the aim of this study was to investigate the texture characteristics of altered PAG in episodic migraine (EM) patients based on high resolution brain structural magnetic resonance (MR) images. Materials and Methods: The brain structural MR images were obtained from 18 normal controls (NC), 18 EM patients and 16 chronic migraine (CM) patients using a 3T MR system...
January 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29353652/modeling-of-normal-tissue-complications-using-imaging-and-biomarkers-after-radiation-therapy-for-hepatocellular-carcinoma
#7
Issam El Naqa, Adam Johansson, Dawn Owen, Kyle Cuneo, Yue Cao, Martha Matuszak, Latifa Bazzi, Theodore S Lawrence, Randall K Ten Haken
PURPOSE: To develop normal tissue complications (NTCP) models for hepatocellular cancer (HCC) patients who undergo liver radiation therapy (RT) and to evaluate the potential role of functional imaging and measurement of blood-based circulating biological markers before and during RT to improve the performance of these models. METHODS AND MATERIALS: The data from 192 HCC patients who had undergone RT from 2005 to 2014 were evaluated. Of the 192 patients, 146 had received stereotactic body RT (SBRT) and 46 had received conventional RT to a median physical tumor dose of 49...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29351281/automatic-labeling-of-molecular-biomarkers-of-immunohistochemistry-images-using-fully-convolutional-networks
#8
Fahime Sheikhzadeh, Rabab K Ward, Dirk van Niekerk, Martial Guillaud
This paper addresses the problem of quantifying biomarkers in multi-stained tissues based on the color and spatial information of microscopy images of the tissue. A deep learning-based method that can automatically localize and quantify the regions expressing biomarker(s) in any selected area on a whole slide image is proposed. The deep learning network, which we refer to as Whole Image (WI)-Net, is a fully convolutional network whose input is the true RGB color image of a tissue and output is a map showing the locations of each biomarker...
2018: PloS One
https://www.readbyqxmd.com/read/29351001/precision-medicine-in-asthma-integrating-imaging-and-inflammatory-biomarkers
#9
Francis Thien, Bruce R Thompson
No abstract text is available yet for this article.
January 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29350536/diagnostic-accuracy-of-functional-imaging-and-biochemical-tests-for-patients-presenting-with-chest-pain-to-the-emergency-department-a-systematic-review-and-meta-analysis
#10
Mario Iannaccone, Sebastiano Gili, Ovidio De Filippo, Salvatore D'Amico, Marco Gagliardi, Maurizio Bertaina, Silvia Mazzilli, Sara Rettegno, Federica Bongiovanni, Paolo Gatti, Fabrizio Ugo, Giacomo G Boccuzzi, Salvatore Colangelo, Silvia Prato, Claudio Moretti, Maurizio D'Amico, Patrizia Noussan, Roberto Garbo, David Hildick-Smith, Fiorenzo Gaita, Fabrizio D'Ascenzo
BACKGROUND: Non-invasive ischaemia tests and biomarkers are widely adopted to rule out acute coronary syndrome in the emergency department. Their diagnostic accuracy has yet to be precisely defined. METHODS: Medline, Cochrane Library CENTRAL, EMBASE and Biomed Central were systematically screened (start date 1 September 2016, end date 1 December 2016). Prospective studies (observational or randomised controlled trial) comparing functional/imaging or biochemical tests for patients presenting with chest pain to the emergency department were included...
January 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29348593/temporal-diabetes-induced-biochemical-changes-in-distinctive-layers-of-mouse-retina
#11
Ebrahim Aboualizadeh, Christine M Sorenson, Alex J Schofield, Miriam Unger, Nader Sheibani, Carol J Hirschmugl
To discover the mechanisms underlying the progression of diabetic retinopathy (DR), a more comprehensive understanding of the biomolecular processes in individual retinal cells subjected to hyperglycemia is required. Despite extensive studies, the changes in the biochemistry of retinal layers during the development of DR are not well known. In this study, we aimed to determine a more detailed understanding of the natural history of DR in Akita/+ (type 1 diabetes model) male mice with different duration of diabetes...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348317/head-to-head-comparison-of-11c-pbr28-and-18f-ge180-for-the-quantification-of-tspo-in-the-human-brain
#12
Paolo Zanotti-Fregonara, Belen Pascual, Gaia Rizzo, Meixiang Yu, Neha Pal, David Beers, Randall Carter, Stanley Appel, Nazem Atassi, Joseph Masdeu
Introduction:18F-GE180 is a third-generation positron emission tomography (PET) tracer to quantify the translocator protein TSPO, a biomarker for inflammation. The aim of this study was to compare head-to-head 18F-GE180 to the well-established translocator protein (TSPO) tracer 11C-PBR28, by scanning with either tracer during the same day in the same subjects. Materials and Methods: Five subjects underwent a 90-minute PET scan with 11C-PBR28 in the morning and 18F-GE180 in the afternoon. A metabolite-corrected arterial input function was obtained in each subject for both tracers, and the brain uptake was quantified with a two-tissue compartmental model...
January 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29348041/executive-dysfunction-in-autism-spectrum-disorder-is-associated-with-a-failure-to-modulate-frontoparietal-insular-hub-architecture
#13
Charles J Lynch, Andrew L Breeden, Xiaozhen You, Ruth Ludlum, William D Gaillard, Lauren Kenworthy, Chandan J Vaidya
BACKGROUND: Comorbid executive dysfunction in autism spectrum disorder (ASD) is a barrier to adaptive functioning, despite remittance of core social-communication symptoms. Network models of ASD address core symptoms but not comorbid executive dysfunction. Following recent demonstrations in healthy adults that, with increasing executive demands, hubs embedded within frontoparietal-insular control networks interact with a more diverse set of networks, we hypothesized that the capability of hubs to do so is perturbed in ASD and predicts executive behavior...
September 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29346507/activity-and-safety-of-afatinib-in-a-window-pre-operative-eortc-study-in-patients-with-squamous-cell-carcinoma-of-the-head-and-neck-scchn
#14
J P Machiels, P Bossi, J Menis, M Lia, C Fortpied, Y Liu, R Lhommel, M Lemort, S Schmitz, S Canevari, L De Cecco, M Guzzo, R Bianchi, P Quattrone, F Crippa, T Duprez, Y Lalami, M Quiriny, N de Saint Aubain, P M Clement, R Coropciuc, E Hauben, L F Licitra
Background: To investigate the activity and safety of afatinib in the pre-operative treatment of squamous cell carcinoma of the head and neck (SCCHN). Patients and methods: This study was an open-label, randomized, multicenter, phase II window of opportunity trial. Treatment-naïve SCCHN patients selected for primary curative surgery were randomized (5:1 ratio) to receive afatinib during 14 days (day -15 until day -1) before surgery (day 0) or no treatment. Tumor biopsies, 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET), and magnetic resonance imaging (MRI) were performed at diagnosis and just before surgery...
January 15, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29346214/validation-of-biomarkers-for-early-detection-of-pancreatic-cancer-summary-of-the-alliance-of-pancreatic-cancer-consortia-for-biomarkers-for-early-detection-workshop
#15
Matthew R Young, Paul D Wagner, Sharmistha Ghosh, Jo Ann Rinaudo, Stuart G Baker, Kenneth S Zaret, Michael Goggins, Sudhir Srivastava
Pancreatic cancer is the third leading cause of cancer death in the United States, and the 5-year relative survival for patients diagnosed with pancreatic cancer is less than 10%. Early intervention is the key to a better survival outcome. Currently, there are no biomarkers that can reliably detect pancreatic cancer at an early stage or identify precursors that are destined to progress to malignancy. The National Cancer Institute in partnership with the Kenner Family Research Fund and the Pancreatic Cancer Action Network convened a Data Jamboree on Biomarkers workshop on December 5, 2016, to discuss and evaluate existing or newly developed biomarkers and imaging methods for early detection of pancreatic cancer...
February 2018: Pancreas
https://www.readbyqxmd.com/read/29344009/evaluation-of-nipple-aspirate-fluid-as-a-diagnostic-tool-for-early-detection-of-breast-cancer
#16
REVIEW
Sadr-Ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Richard Linforth, Mohamed Salhab, Chris Sutton
There has been tremendous progress in detection of breast cancer in postmenopausal women, resulting in two-thirds of women surviving more than 20 years after treatment. However, breast cancer remains the leading cause of cancer-related deaths in premenopausal women. Breast cancer is increasing in younger women due to changes in life-style as well as those at high risk as carriers of mutations in high-penetrance genes. Premenopausal women with breast cancer are more likely to be diagnosed with aggressive tumours and therefore have a lower survival rate...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29343982/increased-theta-band-eeg-power-in-sickle-cell-disease-patients
#17
Michelle Case, Sina Shirinpour, Huishi Zhang, Yvonne H Datta, Stephen C Nelson, Karim T Sadak, Kalpna Gupta, Bin He
Objective: Pain is a major issue in the care of patients with sickle cell disease (SCD). The mechanisms behind pain and the best way to treat it are not well understood. We studied how electroencephalography (EEG) is altered in SCD patients. Methods: We recruited 20 SCD patients and compared their resting state EEG to that of 14 healthy controls. EEG power was found across frequency bands using Welch's method. Electrophysiological source imaging was assessed for each frequency band using the eLORETA algorithm...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29343955/lysyl-oxidase-activates-cancer-stromal-cells-and-promotes-gastric-cancer-progression-quantum-dot-based-identification-of-biomarkers-in-cancer-stromal-cells
#18
Chunwei Peng, Jiuyang Liu, Guifang Yang, Yan Li
Purpose: Semiconductor quantum dots (QDs) are a promising alternative to organic fluorescent dyes for multiplexed molecular imaging of cancer stroma, which have great advantages in holistically analyzing the complex interactions among cancer stromal components in situ. Patients and methods: A QD probe-based multiplexed spectral molecular imaging method was established for simultaneous imaging. Three tissue microarrays (TMAs) including 184 gastric cancer (GC) tissues were constructed for the study...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29343816/sclerotic-bone-lesions-as-a-potential-imaging-biomarker-for-the-diagnosis-of-tuberous-sclerosis-complex
#19
Susanne Brakemeier, Lars Vogt, Lisa C Adams, Bianca Zukunft, Gerd Diederichs, Bernd Hamm, Klemens Budde, Kai-Uwe Eckardt, Marcus R Makowski
Tuberous-sclerosis-complex (TSC) is associated with a high lifetime risk of severe complications. Clinical manifestations are largely variable and diagnosis is often missed. Sclerotic-bone-lesions (SBL) could represent a potential imaging biomarker for the diagnosis of TSC. In this study, computed tomography (CT) data sets of 49 TSC patients (31 females) were included and compared to an age/sex matched control group. Imaging features of SBLs included frequency, size and location pattern. Sensitivities, specificities and cutoff values for the diagnosis of TSC were established for the skull, thorax, and abdomen/pelvis...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342213/circulating-neutrophil-transcriptome-may-reveal-intracranial-aneurysm-signature
#20
Vincent M Tutino, Kerry E Poppenberg, Kaiyu Jiang, James N Jarvis, Yijun Sun, Ashish Sonig, Adnan H Siddiqui, Kenneth V Snyder, Elad I Levy, John Kolega, Hui Meng
BACKGROUND: Unruptured intracranial aneurysms (IAs) are typically asymptomatic and undetected except for incidental discovery on imaging. Blood-based diagnostic biomarkers could lead to improvements in IA management. This exploratory study examined circulating neutrophils to determine whether they carry RNA expression signatures of IAs. METHODS: Blood samples were collected from patients receiving cerebral angiography. Eleven samples were collected from patients with IAs and 11 from patients without IAs as controls...
2018: PloS One
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