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https://www.readbyqxmd.com/read/28231582/radiomics-in-head-and-neck-cancer-extracting-valuable-information-from-data-beyond-recognition
#1
Kathrin Scheckenbach, Lena Colter, Martin Wagenmann
In oncology, biomarkers that describe the characteristics of a malignancy on different levels (clinical, histological, molecular) and the patient's outcome and treatment response are increasingly integrated into the clinical routine. Extensive screening tools, "omics," offer incredible opportunities and vast amounts of data. During the last years, the field of "omics" gained a new promising partner, the "radiomics." Based on radiological imaging, multiple features can be extracted and linked to clinical, genomic, and histopathological data from other sources...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28231575/individual-biomarkers-using-molecular-personalized-medicine-approaches
#2
Hans P Zenner
Molecular personalized medicine tries to generate individual predictive biomarkers to assist doctors in their decision making. These are thought to improve the efficacy and lower the toxicity of a treatment. The molecular basis of the desired high-precision prediction is modern "omex" technologies providing high-throughput bioanalytical methods. These include genomics and epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, imaging, and functional analyses. In most cases, producing big data also requires a complex biomathematical analysis...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28231282/mindboggling-morphometry-of-human-brains
#3
Arno Klein, Satrajit S Ghosh, Forrest S Bao, Joachim Giard, Yrjö Häme, Eliezer Stavsky, Noah Lee, Brian Rossa, Martin Reuter, Elias Chaibub Neto, Anisha Keshavan
Mindboggle (http://mindboggle.info) is an open source brain morphometry platform that takes in preprocessed T1-weighted MRI data and outputs volume, surface, and tabular data containing label, feature, and shape information for further analysis. In this article, we document the software and demonstrate its use in studies of shape variation in healthy and diseased humans. The number of different shape measures and the size of the populations make this the largest and most detailed shape analysis of human brains ever conducted...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28230967/live-cell-pyrophosphate-imaging-by-in-situ-hot-spot-generation
#4
Mingmin Li, Jin Li, Huixia Di, Huiqiao Liu, Dingbin Liu
Controlling the electromagnetic hot-spot generation is essential for surface-enhanced Raman scattering (SERS) assays. Current hot spot-based SERS assays have been extensively studied in solutions or on substrates. However, probing biospecies by controlling the hot-spot assembly in living systems has not been demonstrated thus far. Herein, we report a background-free SERS probe for imag-ing pyrophosphate (PPi), a biochemically significant anion, in living cells. Intracellular PPi is able to induce the nanoparticle dimeri-zation, thus creating an intense electromagnetic hot spot and dramatically enhancing the signal of the Raman reporters residing in the hot spot...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230716/experimental-texture-analysis-in-glioblastoma-a-methodological-study
#5
Nicolin Hainc, Christoph Stippich, Bram Stieltjes, Severina Leu, Andrea Bink
OBJECTIVES: Analysis of a single slice of a tumor to extract biomarkers for texture analysis may result in loss of information. We investigated correlation of fractional volumes to entire tumor volumes and introduced expanded regions of interest (ROIs) outside the visual tumor borders in glioblastoma. MATERIALS AND METHODS: Retrospective slice-by-slice volumetric texture analysis on 46 brain magnetic resonance imaging subjects with histologically confirmed glioblastoma was performed...
February 22, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28229894/mobile-stroke-units-for-prehospital-thrombolysis-triage-and-beyond-benefits-and-challenges
#6
REVIEW
Klaus Fassbender, James C Grotta, Silke Walter, Iris Q Grunwald, Andreas Ragoschke-Schumm, Jeffrey L Saver
In acute stroke management, time is brain. Bringing swift treatment to the patient, instead of the conventional approach of awaiting the patient's arrival at the hospital for treatment, is a potential strategy to improve clinical outcomes after stroke. This strategy is based on the use of an ambulance (mobile stroke unit) equipped with an imaging system, a point-of-care laboratory, a telemedicine connection to the hospital, and appropriate medication. Studies of prehospital stroke treatment consistently report a reduction in delays before thrombolysis and cause-based triage in regard to the appropriate target hospital (eg, primary vs comprehensive stroke centre)...
March 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28229841/-neuroimaging-and-blood-biomarkers-in-functional-prognosis-after-stroke
#7
REVIEW
João Paulo Branco, Joana Santos Costa, João Sargento-Freitas, Sandra Oliveira, Bruno Mendes, Jorge Laíns, João Pinheiro
INTRODUCTION: Stroke remains one of the leading causes of morbidity and mortality around the world and it is associated with an important long-term functional disability. Some neuroimaging resources and certain peripheral blood or cerebrospinal fluid proteins can give important information about etiology, therapeutic approach, follow-up and functional prognosis in acute ischemic stroke patients. However, among the scientific community, there is currently more interest in the stroke vital prognosis over the functional prognosis...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28227678/illumination-and-device-independence-for-colorimetric-detection-of-urinary-biomarkers-with-smartphone
#8
Haakon Karisen, Tao Dong, Haakon Karisen, Tao Dong, Tao Dong
Diaper wearing elderly with functional impairments and/or incontinence is at high risk of contracting urinary tract infections. Nurses struggle with collection of urine samples for analysis. Therefore, a smartphone application is under development as a rapid screening device to work in conjunction with a colorimetric diaper assay that collects and tests urine within a diaper. The focus of this work is to make a practical and useful tool that medical personnel (the user) can use for rapid screening on patients in the field, only with a smartphone and assay available...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227410/localized-mri-and-histological-image-correlation-in-a-canine-model-of-duchenne-muscular-dystrophy
#9
A Eresen, S McConnell, S M Birch, J F Griffin, J N Kornegay, J X Ji, A Eresen, S McConnell, S M Birch, J F Griffin, J N Kornegay, J X Ji, J X Ji, J F Griffin, S McConnell, S M Birch, A Eresen, J N Kornegay
Duchenne Muscular Dystrophy (DMD) is a fatal X-linked disorder. Therapeutic assessments currently require muscle biopsy to ascertain information about the status of disease progression. MRI shows potential to be used in place of muscle biopsy for therapeutic assessments. In this work, localized histological data and various MRI parameters were correlated in a canine model of DMD. The results indicate several MRI parameters may be useful as biomarkers of disease progression.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227407/recursive-feature-elimination-for-biomarker-discovery-in-resting-state-functional-connectivity
#10
Hariharan Ravishankar, Radhika Madhavan, Rakesh Mullick, Teena Shetty, Luca Marinelli, Suresh E Joel, Hariharan Ravishankar, Radhika Madhavan, Rakesh Mullick, Teena Shetty, Luca Marinelli, Suresh E Joel, Suresh E Joel, Teena Shetty, Luca Marinelli, Rakesh Mullick, Hariharan Ravishankar, Radhika Madhavan
Biomarker discovery involves finding correlations between features and clinical symptoms to aid clinical decision. This task is especially difficult in resting state functional magnetic resonance imaging (rs-fMRI) data due to low SNR, high-dimensionality of images, inter-subject and intra-subject variability and small numbers of subjects compared to the number of derived features. Traditional univariate analysis suffers from the problem of multiple comparisons. Here, we adopt an alternative data-driven method for identifying population differences in functional connectivity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227392/structural-and-functional-changes-during-epileptogenesis-in-the-mouse-model-of-medial-temporal-lobe-epilepsy
#11
Yvan Dietrich, Pierre-Antoine Eliat, Gabriel Dieuset, Herve Saint-Jalmes, Charles Pineau, Fabrice Wendling, Benoit Martin, Yvan Dietrich, Pierre-Antoine Eliat, Gabriel Dieuset, Herve Saint-Jalmes, Charles Pineau, Fabrice Wendling, Benoit Martin, Pierre-Antoine Eliat, Charles Pineau, Benoit Martin, Gabriel Dieuset, Yvan Dietrich, Herve Saint-Jalmes, Fabrice Wendling
An important issue in epilepsy research is to understand the structural and functional modifications leading to chronic epilepsy, characterized by spontaneous recurrent seizures, after initial brain insult. To address this issue, we recorded and analyzed electroencephalography (EEG) and quantitative magnetic resonance imaging (MRI) data during epileptogenesis in the in vivo mouse model of Medial Temporal Lobe Epilepsy (MTLE, kainate). Besides, this model of epilepsy is a particular form of drug-resistant epilepsy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227225/integration-of-snps-fmri-methylation-data-with-sparse-multi-cca-for-schizophrenia-study
#12
Wenxing Hu, Dongdong Lin, Vince D Calhoun, Yu-Ping Wang, Wenxing Hu, Dongdong Lin, Vince D Calhoun, Yu-Ping Wang, Vince D Calhoun, Yu-Ping Wang, Wenxing Hu, Dongdong Lin
Schizophrenia (SZ) is a complex mental disorder associated with genetic variations, brain development and activities, and environmental factors. There is an increasing interest in combining genetic, epigenetic and neuroimaging datasets to explore different level of biomarkers for the correlation and interaction between these diverse factors. Sparse Multi-Canonical Correlation Analysis (sMCCA) is a powerful tool that can analyze the correlation of three or more datasets. In this paper, we propose the sMCCA model for imaging genomics study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227209/high-speed-in-vivo-imaging-of-retinal-hemodynamics-in-a-rodent-model-of-hypertension
#13
Mahdieh Rezaeian, Dana Georgevsky, S Mojtaba Golzan, Stuart L Graham, Mahdieh Rezaeian, Dana Georgevsky, S Mojtaba Golzan, Stuart L Graham, Dana Georgevsky, Mahdieh Rezaeian, S Mojtaba Golzan, Stuart L Graham
The eye is the only organ through which microcirculation can be visualized non-invasively. This unique feature makes the eye and specifically retinal vasculature an excellent target area to monitor and study micro-vascular damage in systemic diseases. Dynamic (real-time) changes of retinal vessels have been shown to be more specific to the disease in comparison with static measurements. In this study we utilize high speed imaging (i.e. 125 fps) to study and derive dynamic changes of retinal vessels in a rat model of hypertension...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226698/differences-in-connectivity-patterns-between-child-and-adolescent-attention-deficit-hyperactivity-disorder-patients
#14
Bo-Yong Park, Jonghoon Kim, Hyunjin Park, Bo-Yong Park, Jonghoon Kim, Hyunjin Park, Hyunjin Park, Bo-Yong Park, Jonghoon Kim
Attention deficit hyperactivity disorder (ADHD) is a common psychological disorder for a broad range of ages. Child and adolescent ADHD patients show different behavior patterns. The differences between child and adolescent ADHD patients have not been fully explored in terms of brain connectivity. In this study, we explored the differences of connectivity patterns between child and adolescent ADHD patients using resting-state functional magnetic resonance imaging (rs-fMRI) of 52 ADHD patients (26 children and 26 adolescents)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224398/development-of-imaging-biomarkers-and-generation-of-big-data
#15
Ángel Alberich-Bayarri, Rafael Hernández-Navarro, Enrique Ruiz-Martínez, Fabio García-Castro, David García-Juan, Luis Martí-Bonmatí
Several image processing algorithms have emerged to cover unmet clinical needs but their application to radiological routine with a clear clinical impact is still not straightforward. Moving from local to big infrastructures, such as Medical Imaging Biobanks (millions of studies), or even more, Federations of Medical Imaging Biobanks (in some cases totaling to hundreds of millions of studies) require the integration of automated pipelines for fast analysis of pooled data to extract clinically relevant conclusions, not uniquely linked to medical imaging, but in combination to other information such as genetic profiling...
February 21, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28224285/abnormal-effective-connectivity-in-the-brain-is-involved-in-auditory-verbal-hallucinations-in-schizophrenia
#16
Baojuan Li, Long-Biao Cui, Yi-Bin Xi, Karl J Friston, Fan Guo, Hua-Ning Wang, Lin-Chuan Zhang, Yuan-Han Bai, Qing-Rong Tan, Hong Yin, Hongbing Lu
Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations (AVHs) in schizophrenia (SZ) remains unclear. In this study, we used stochastic dynamic causal modeling (sDCM) to quantify connections among the left dorsolateral prefrontal cortex (inner speech monitoring), auditory cortex (auditory processing), hippocampus (memory retrieval), thalamus (information filtering), and Broca's area (language production) in 17 first-episode drug-naïve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging...
February 21, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28223932/cerebrospinal-fluid-levels-of-amyloid-beta-1-43-mirror-1-42-in-relation-to-imaging-biomarkers-of-alzheimer-s-disease
#17
Ina S Almdahl, Camilla Lauridsen, Per Selnes, Lisa F Kalheim, Christopher Coello, Beata Gajdzik, Ina Møller, Marianne Wettergreen, Ramune Grambaite, Atle Bjørnerud, Geir Bråthen, Sigrid B Sando, Linda R White, Tormod Fladby
Introduction: Amyloid beta 1-43 (Aβ43), with its additional C-terminal threonine residue, is hypothesized to play a role in early Alzheimer's disease pathology possibly different from that of amyloid beta 1-42 (Aβ42). Cerebrospinal fluid (CSF) Aβ43 has been suggested as a potential novel biomarker for predicting conversion from mild cognitive impairment (MCI) to dementia in Alzheimer's disease. However, the relationship between CSF Aβ43 and established imaging biomarkers of Alzheimer's disease has never been assessed...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28223713/reduced-white-matter-integrity-in-antisocial-personality-disorder-a-diffusion-tensor-imaging-study
#18
Weixiong Jiang, Feng Shi, Huasheng Liu, Gang Li, Zhongxiang Ding, Hui Shen, Celina Shen, Seong-Whan Lee, Dewen Hu, Wei Wang, Dinggang Shen
Emerging neuroimaging research suggests that antisocial personality disorder (ASPD) may be linked to abnormal brain anatomy, but little is known about possible impairments of white matter microstructure in ASPD, as well as their relationship with impulsivity or risky behaviors. In this study, we systematically investigated white matter abnormalities of ASPD using diffusion tensor imaging (DTI) measures: fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD). Then, we further investigated their correlations with the scores of impulsivity or risky behaviors...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28222921/relationships-between-left-ventricular-structure-and-function-according-to-cardiac-mri-and-cardiac-biomarkers-in-end-stage-renal-disease
#19
Bryan A Ross, Ron Wald, Marc B Goldstein, Darren A Yuen, Jonathon Leipsic, Mercedeh Kiaii, Andrea Rathe, Djeven P Deva, Anish Kirpalani, Olugbenga O Bello, John J Graham, Howard Leong-Poi, Kim A Connelly, Andrew T Yan
BACKGROUND: We sought to assess the relationships between left ventricular (LV) remodelling and the mechanical and uremic stressors in hemodialysis patients. METHODS: In this prospective 2-centre cohort study, 67 prevalent hemodialysis patients were followed for 1 year. Data on routine bloodwork and predialysis blood pressure (BP) measurements were collected over a 12-week period. LV end-diastolic volume (LVEDV) and LV mass (LVM) were measured using cardiac magnetic resonance imaging and indexed...
December 3, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28222503/selenium-levels-in-serum-red-blood-cells-and-cerebrospinal-fluid-of-alzheimer-s-disease-patients-a-report-from-the-australian-imaging-biomarker-lifestyle-flagship-study-of-ageing-aibl
#20
Bárbara R Cardoso, Dominic J Hare, Ashley I Bush, Qiao-Xin Li, Christopher J Fowler, Colin L Masters, Ralph N Martins, Katherine Ganio, Amber Lothian, Soumya Mukherjee, Eugene A Kapp, Blaine R Roberts
Selenium (Se) protects cells against oxidative stress damage through a range of bioactive selenoproteins. Increased oxidative stress is a prominent feature of Alzheimer's disease (AD), and previous studies have shown that Se deficiency is associated with age-related cognitive decline. In this study, we assessed Se status in different biofluids from a subgroup of participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. As Se in humans can either be an active component of selenoproteins or inactive via non-specific incorporation into other proteins, we used both size exclusion chromatography-inductively coupled plasma-mass spectrometry (SEC-ICP-MS) and tandem mass spectrometry to characterize selenoproteins in serum...
February 10, 2017: Journal of Alzheimer's Disease: JAD
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