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Positron emission tomography

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https://www.readbyqxmd.com/read/29244904/pharmacokinetics-of-the-cannabinoid-receptor-ligand-18-f-mk-9470-in-the-rat-brain-evaluation-of-models-using-micropet
#1
Isabelle Miederer, Hans-Georg Buchholz, Andrea Kronfeld, Stephan Maus, Veronika Weyer-Elberich, Philipp Mildenberger, Beat Lutz, Mathias Schreckenberger
PURPOSE: The positron emission tomography ligand [18 F]MK-9470 is an inverse agonist that binds reversibly and with high affinity to the cannabinoid type 1 receptor. Due to its slow brain kinetics, care is required in the definition of its dissociation rates from the receptor. The goal of this study was to investigate pharmacokinetic analysis methods using an arterial input function. METHODS: Five Sprague-Dawley rats received injections of 13 to 25 MBq of [18 F]MK-9470 and were scanned over a period of 90 min...
December 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/29244780/a-practical-method-for-the-preparation-of-18f-labeled-aromatic-amino-acids-from-nucleophilic-18f-fluoride-and-stannyl-precursors-for-electrophilic-radiohalogenation
#2
Fadi Zarrad, Boris D Zlatopolskiy, Philipp Krapf, Johannes Zischler, Bernd Neumaier
In a recent contribution of Scott et al., the substrate scope of Cu-mediated nucleophilic radiofluorination with [18F]KF for the preparation of 18F-labeled arenes was extended to aryl- and vinylstannanes. Based on these findings, the potential of this reaction for the production of clinically relevant positron emission tomography (PET) tracers was investigated. To this end, Cu-mediated radiofluorodestannylation using trimethyl(phenyl)tin as a model substrate was re-evaluated with respect to different reaction parameters...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29244720/functional-imaging-with-18f-fdg-pet-ct-and-diffusion-weighted-imaging-dwi-in-early-response-evaluation-of-combination-therapy-of-elotuzumab-lenalidomide-and-dexamethasone-in-a-relapsed-multiple-myeloma-patient
#3
Christos Sachpekidis, Antonia Dimitrakopoulou-Strauss, Stefan Delorme, Hartmut Goldschmidt
Elotuzumab is the first monoclonal antibody approved for the treatment of relapsed-refractory multiple myeloma (MM) in combination with lenalidomide, an immunodulatory drug, and dexamethasone. We report on a multiply pre-treated MM patient with disease progression due to appearance of new focal lesions on imaging modalities, who was started on a combination treatment of elotuzumab, lenalidomide, and dexamethasone. After completion of three cycles of the new therapy the patient responded very well with a major decline of serological myeloma activity parameters serum monoclonal protein, kappa light chains, free light chains (FLC) ratio...
December 15, 2017: Diagnostics
https://www.readbyqxmd.com/read/29244101/18f-fdg-positron-emission-tomography-computed-tomography-for-diagnosis-of-pump-housing-infections-in-patients-on-left-ventricular-assist-devices-should-we-contain-our-initial-enthusiasm
#4
Angelo Maria Dell'Aquila, Jürgen R Sindermann
No abstract text is available yet for this article.
December 12, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29243665/anthropomorphic-thorax-phantom-for-cardio-respiratory-motion-simulation-in-tomographic-imaging
#5
Konstantin Bolwin, Björn Czekalla, Lynn Johann Frohwein, Florian Buther, Klaus P Schäfers
Patient motion during medical imaging using techniques such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), or single emission computed tomography (SPECT) is well known to degrade images leading to blurring effects or severe artifacts. Motion correction methods try to overcome this degrading effects. However, they need to be validated under realistic conditions. In the present work, a sophisticated anthropomorphic thorax phantom is presented that combines several aspects of a simulator for cardio-respiratory motion...
December 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29242734/images-from-18f-dopa-scan-in-congenital-hyperinsulinism-not-always-a-clue-for-diagnosis
#6
Evelina Maines, Luca Giacomello, Mirko D'Onofrio, Matteo Salgarello, Rossella Gaudino, Laura Baggio, Andrea Bordugo
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in childhood (Horm Res 70:65-72, 2008; J Clin Endocr Metab 93:869-875, 2008). 18-Fluoro-L-dihydroxy-phenylalanine (18F-DOPA) positron emission tomography (PET) can detect areas of increased activity in the pancreas and may differentiate focal from diffuse CHI (J Clin Endocr Metab 93:869-875, 2008; Radiology 253:216-222, 2009). We here report the case of a girl who complained of recurrent episodes of severe hypoglycaemia despite previous partial pancreatectomy...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29242731/recurrent-follicular-dendritic-cell-sarcoma-of-the-parotid-gland-imaged-with-18f-fdg-pet-ct
#7
William Makis, E W Hudson, Brian Chiu
Follicular dendritic cell sarcoma (FDCS) is an extremely rare tumor with only 67 cases of head and neck FDCS reported in the literature. A 65-year-old female had a 6-cm follicular dendritic cell sarcoma resected from the left parotid gland with close margins. It recurred 1 year later as a 5-cm mass that was intensely [18F] fluoro-2-deoxy-D-glucose (18F-FDG) avid on positron emission tomography/computed tomography (PET/CT) and was re-excised. A follow-up PET/CT did not show any metastatic disease. The use of 18F-FDG PET/CT in the management of FDCS warrants further research...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29242730/unusual-contralateral-axillary-lymph-node-metastasis-in-a-second-primary-breast-cancer-detected-by-fdg-pet-ct-and-lymphoscintigraphy
#8
Ji-Young Kim, Hyunjong Lee, Tae Sung Kim, Han-Sung Kang, Seok-Ki Kim
Contralateral metastatic axillary lymph nodes in a patient with breast cancer is a rare condition. Here, we present a 55-year-old woman with a second primary breast cancer. The patient underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) for staging work-up. Additionally, preoperative lymphoscintigraphy was performed to detect sentinel lymph nodes. FDG PET/CT demonstrated increased FDG uptake in the left nipple and right axillary lymph nodes. Lymphoscintigraphy identified the right axillary lymph nodes which was consistent with the FDG PET/CT findings...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29242726/relationship-between-dual-time-point-fdg-pet-ct-and-clinical-prognostic-indexes-in-patients-with-high-grade-lymphoma-a-pilot-study
#9
Do Hyoung Lim, Jai Hyuen Lee
Purpose: This study investigated the correlative relationship between metabolic parameters estimated from dual time point 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG) positron emission tomography/computerized tomography (PET/CT) and the clinical tools predicting the outcome of a lymphoma. We also measured metabolic and volumetric alterations between early and delayed 18F-FDG PET/CT in patients with high grade lymphoma (HGL). Methods: The samples were 122 lymph nodes and extralymphatic lesions from 26 patients diagnosed with HGL...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29242725/68ga-psma-pet-ct-imaging-predicting-intraprostatic-tumor-extent-extracapsular-extension-and-seminal-vesicle-invasion-prior-to-radical-prostatectomy-in-patients-with-prostate-cancer
#10
Christoph-Alexander J von Klot, Axel S Merseburger, Alena Böker, Sebastian Schmuck, Tobias L Ross, Frank M Bengel, Markus A Kuczyk, Christoph Henkenberens, Hans Christiansen, Hans-Jürgen Wester, Wiebke Solass, Marcel Lafos, Thorsten Derlin
Purpose: 68Ga-labeled prostate-specific membrane antigen (PSMA) ligand positron emission tomography/computed tomography (PET/CT) has shown promising results in patients with biochemical recurrence after primary therapy for prostate cancer. In this study, we evaluated the usefulness of PSMA I&T (imaging and therapy) PET/CT prior to radical prostatectomy. Methods: The study population consisted of 21 patients with prostate cancer who underwent 68Ga-PSMA I&T PET/CT before either open or laparoscopic radical prostatectomy...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29242606/murine-stroma-adopts-a-human-like-metabolic-phenotype-in-the-pdx-model-of-colorectal-cancer-and-liver-metastases
#11
Arnaud Blomme, Gaetan Van Simaeys, Gilles Doumont, Brunella Costanza, Justine Bellier, Yukihiro Otaka, Félicie Sherer, Pierre Lovinfosse, Sébastien Boutry, Ana Perez Palacios, Edwin De Pauw, Touko Hirano, Takehiko Yokobori, Roland Hustinx, Akeila Bellahcène, Philippe Delvenne, Olivier Detry, Serge Goldman, Masahiko Nishiyama, Vincent Castronovo, Andrei Turtoi
Cancer research is increasingly dependent of patient-derived xenograft model (PDX). However, a major point of concern regarding the PDX model remains the replacement of the human stroma with murine counterpart. In the present work we aimed at clarifying the significance of the human-to-murine stromal replacement for the fidelity of colorectal cancer (CRC) and liver metastasis (CRC-LM) PDX model. We have conducted a comparative metabolic analysis between 6 patient tumors and corresponding PDX across 4 generations...
December 15, 2017: Oncogene
https://www.readbyqxmd.com/read/29242404/head-to-head-comparison-of-68ga-psma-11-pet-ct-and-18f-fluciclovine-pet-ct-in-a-case-series-of-10-patients-with-prostate-cancer-recurrence
#12
Jeremie Calais, Wolfgang P Fendler, Ken Herrmann, Matthias Eiber, Francesco Ceci
Purpose: This is a head-to-head comparison between Gallium-68 Prostate Specific Membrane Antigen (68Ga-PSMA-11) and 18F-Fluciclovine Positron Emission Tomography/Computed Tomography (PET/CT) in a series of 10 patients with prostate cancer (PCa) recurrence. Methods: 288 patients with PCa recurrence were enrolled in a prospective study of 68Ga-PSMA-11 PET/CT imaging for recurrent disease localization (NCT02940262). We retrospectively identified 10 patients who underwent clinical indicated 18F-Fluciclovine PET/CT prior enrollment...
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29242403/does-pet-reconstruction-method-affect-deauville-scoring-in-lymphoma-patients
#13
Blandine Enilorac, Charline Lasnon, Cathy Nganoa, Christophe Fruchart, Anne Claire Gac, Gandhi Damaj, Nicolas Aide
Background: When scoring 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) with the Deauville scale (DS), the quantification of tumor and reference organs limits the problem of optical misinterpretation. Compared to conventional reconstruction algorithms, point spread function (PSF) modeling significantly increases standardized uptake values (SUVs) in tumors but only moderately in the liver, which could affect the DS. We investigated whether the choice of the reconstruction algorithm affects the DS and whether discordances affect the capability of FDG PET to stratify lymphoma patients...
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29242399/novel-functional-renal-imaging-with-18f-fds-pet-in-rat-models-of-kidney-diseases
#14
Rudolf Werner, Hiroshi Wakabayashi, Xinyu Chen, Mitsuru Hirano, Tetsuya Shinaji, Constantin Lapa, Steven P Rowe, Mehrbod S Javadi, Takahiro Higuchi
Background: Precise regional quantitative assessment of renal function is limited with conventional 99mTc-labeled renal radiotracers. A recent study reported that the positron emission tomography (PET) radiotracer 2-deoxy-2-18F-fluorosorbitol (18F-FDS) has ideal pharmacokinetics for functional renal imaging. Furthermore, 18F-FDS is available via simple reduction from routinely used 2-deoxy-2-18F-fluoro-D-glucose (18F-FDG). We aimed to further investigate the potential of 18F-FDS PET as a functional renal imaging agent using rat models of kidney diseases...
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29242398/actual-impact-of-68ga-psma-11-pet-ct-on-the-management-of-prostate-cancer-patients-with-biochemical-recurrence
#15
Jérémie Calais, Wolfgang P Fendler, Matthias Eiber, Jeannine Gartmann, Fang-I Chu, Nicholas G Nickols, Robert R Reiter, Matthew B Rettig, Leonard S Marks, Thomas E Ahlering, Lynda Huynh, Roger Slavik, Pawan Gupta, Andrew Quon, Martin S Allen-Auerbach, Johannes Czernin, Ken Herrmann
Purpose: In this prospective survey of referring physicians, we investigated whether and how Gallium-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (PSMA-11 PET/CT) affects the actually implemented management of prostate cancer patients wih biochemical recurrence (BCR). Methods: We conducted a prospective survey of physicians (NCT02940262) who referred 161 patients with prostate cancer BCR (median Prostate Specific Antigen (PSA) value 1.7 ng/ml (range 0.05-202)). Referring physicians completed one questionnaire prior to the scan to indicate the treatment plan without PSMA-11 PET/CT information (Q1; n = 101); one immediately after the scan to denote intended management changes (Q2; n = 101); and one 3 to 6 months later to document the final implemented management (Q3; n = 56)...
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29242276/oral-sodium-butyrate-impacts-brain-metabolism-and-hippocampal-neurogenesis-with-limited-effects-on-gut-anatomy-and-function-in-pigs
#16
David Val-Laillet, Sylvie Guérin, Nicolas Coquery, Isabelle Nogret, Michèle Formal, Véronique Romé, Laurence Le Normand, Paul Meurice, Gwénaëlle Randuineau, Paul Guilloteau, Charles-Henri Malbert, Patricia Parnet, Jean-Paul Lallès, Jean-Pierre Segain
Butyrate can improve gut functions, whereas histone deacetylase inhibitors might alleviate neurocognitive alterations. Our aim was to assess whether oral butyrate could modulate brain metabolism and plasticity and if this would relate to gut function. Sixteen pigs were subjected to sodium butyrate (SB) supplementation via beverage water or water only [control (C)]. All pigs had blood sampled after 2 and 3 wk of treatment, and were subjected to a brain positron emission tomography after 3 wk. Animals were euthanized after 4 wk to sample pancreas, intestine, and brain for gut physiology and anatomy measurements, as well as hippocampal histology, Ki67, and doublecortin (DCX) immunohistochemistry...
December 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29240541/surveillance-or-metastasis-directed-therapy-for-oligometastatic-prostate-cancer-recurrence-a-prospective-randomized-multicenter-phase-ii-trial
#17
Piet Ost, Dries Reynders, Karel Decaestecker, Valérie Fonteyne, Nicolaas Lumen, Aurélie De Bruycker, Bieke Lambert, Louke Delrue, Renée Bultijnck, Tom Claeys, Els Goetghebeur, Geert Villeirs, Kathia De Man, Filip Ameye, Ignace Billiet, Steven Joniau, Friedl Vanhaverbeke, Gert De Meerleer
Purpose Retrospective studies suggest that metastasis-directed therapy (MDT) for oligorecurrent prostate cancer (PCa) improves progression-free survival. We aimed to assess the benefit of MDT in a randomized phase II trial. Patients and Methods In this multicenter, randomized, phase II study, patients with asymptomatic PCa were eligible if they had had a biochemical recurrence after primary PCa treatment with curative intent, three or fewer extracranial metastatic lesions on choline positron emission tomography-computed tomography, and serum testosterone levels > 50 ng/mL...
December 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29239196/clinical-experience-of-positron-emission-tomography-in-infective-aortic-disease
#18
Julian S Tsang, Yiu Che Chan, Yuk Law, Stephen W Cheng
Background Fluorine-18-fluorodeoxyglucose positron-emission tomography with computed tomography has revolutionized medical diagnosis by adding functional activity to anatomic imaging. We report our experience with this technique in patients with mycotic aortic pathology and aortic vascular graft infection. Methods We conducted a retrospective review of a prospective database of patients who underwent 18F-fluorodeoxyglucose positron-emission tomography with computed tomography for suspected infective aortic disease...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29238205/predictive-value-of-interim-pet-ct-visual-interpretation-in-the-prognosis-of-patients-with-aggressive-non-hodgkin-s-lymphoma
#19
Cheng-Cheng Liao, Yun-Ying Qin, Xiao-Hong Tan, Jia-Jie Hu, Qi Tang, Yan Rong, Hong Cen, Le-Qun Li
Objective: The objective of the study was to evaluate the prognostic value of positron emission tomography (PET)/computed tomography (CT) visual interpretation in patients with aggressive non-Hodgkin's lymphoma (NHL) using a meta-analysis and systematic review. Methods: Using the PubMed, Embase, and Web of Science databases, we performed a systematic review of the use of visual evaluation mid-chemotherapy to evaluate the prognosis of aggressive NHL in studies published up to May 2017...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29238109/present-and-future-roles-of-fdg-pet-ct-imaging-in-the-management-of-gastrointestinal-cancer-an-update
#20
REVIEW
Kazuhiro Kitajima, Masatoyo Nakajo, Hayato Kaida, Ryogo Minamimoto, Kenji Hirata, Masakatsu Tsurusaki, Hiroshi Doi, Yoshiko Ueno, Keitaro Sofue, Yukihisa Tamaki, Koichiro Yamakado
Positron emission tomography/computed tomography (PET/CT) integrated with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) is a useful tool for acquisition of both glucose metabolism and anatomic imaging data, as only a single device and one diagnostic session is required, thus opening a new field in clinical oncologic imaging. FDG-PET/CT has been successfully used for initial staging, restaging, assessment of early treatment response, evaluation of metastatic disease response, and prognostication of intestinal cancer as well as various malignant tumors...
November 2017: Nagoya Journal of Medical Science
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