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Positron emission tomography

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https://www.readbyqxmd.com/read/29058224/influence-of-region-of-interest-determination-on-measurement-of-signal-to-noise-ratio-in-liver-on-pet-images
#1
Shinji Amakusa, Koki Matsuoka, Masayuki Kawano, Kiyotaka Hasegawa, Mio Ouchida, Ayaka Date, Tsuyoshi Yoshida, Masayuki Sasaki
OBJECTIVE: On (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography (PET), signal-to-noise ratio in the liver (SNRliver) is used as a metric to assess image quality. However, some regions-of-interest (ROIs) are used when measuring the SNRliver. The purpose of this study is to examine the different ROIs and volumes of interest (VOIs) to obtain a reproducible SNRliver. METHODS: This study included 108 patients who underwent (18)F-FDG-PET/CT scans for the purpose of cancer screening...
October 20, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29058157/potential-of-asphericity-as-a-novel-diagnostic-parameter-in-the-evaluation-of-patients-with-68-ga-psma-hbed-cc-pet-positive-prostate-cancer-lesions
#2
Sebastian Meißner, Jan-Carlo Janssen, Vikas Prasad, Winfried Brenner, Gerd Diederichs, Bernd Hamm, Frank Hofheinz, Marcus R Makowski
BACKGROUND: The aim of this study was to evaluate the diagnostic value of the asphericity (ASP) as a novel quantitative parameter, reflecting the spatial heterogeneity of tracer uptake, in the staging process of patients with (68)Ga-PSMA-HBED-CC positron emission tomography (PET)-positive prostate cancer (PC). In this study, 37 patients (median age 72 years, range 52-82 years) with newly diagnosed PC, who received a (68)Ga-PSMA-HBED-CC PET fused with computed tomography ((68)Ga-PSMA-PET/CT), a magnetic resonance imaging (MRI) of the prostate, and a core needle biopsy (within 74...
October 23, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29057029/transthyretin-cardiac-amyloidosis-in-older-adults-optimizing-cardiac-imaging-to-the-corresponding-diagnostic-and-management-goal
#3
Adam Castaño, Daniel K Manson, Mathew S Maurer, Sabahat Bokhari
PURPOSE OF REVIEW: Transthyretin cardiac amyloidosis is increasingly recognized as an important cause of heart failure in older adults. Many cardiac imaging modalities have evolved to evaluate transthyretin cardiac amyloidosis and include 2D echocardiography with tissue Doppler and speckle-strain imaging, nuclear scintigraphy, cardiac magnetic resonance imaging, and positron emission tomography. The purpose of this review is to highlight the optimal selection of advanced cardiac imaging techniques with corresponding diagnostic goals including raising suspicion, making an early diagnosis, and subtyping transthyretin cardiac amyloid, as well as management goals including assessment of ventricular impairment, prognosticating, and monitoring disease progression...
June 2017: Current Cardiovascular Risk Reports
https://www.readbyqxmd.com/read/29056243/prognostic-significance-of-standardized-uptake-value-on-f18-fdg-pet-ct-in-patients-with-extranodal-nasal-type-nk-t-cell-lymphoma-a-multicenter-retrospective-analysis
#4
Kyoungjune Pak, Bum Soo Kim, Keunyoung Kim, In Joo Kim, Sungmin Jun, Young Jin Jeong, Hye Kyung Shim, Sung-Dong Kim, Kyu-Sup Cho
OBJECTIVES: The purpose of this study was to evaluate the value of parameters assessed with F18-flurodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in predicting relapse free survival and overall survival in patients with extranodal nasal type NK/T cell lymphoma. METHODS: Thirty-six patients with extranodal nasal type NK/T cell lymphoma, and who underwent PET/CT prior to curative treatment, were enrolled at five institutions. Volumes of interest covering the entire tumor volume were delineated on PET/CT images, and the maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured using thresholds of 40% of SUVmax...
October 12, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29056190/positron-emission-tomography-ct-to-localize-radioactivity-in-a-radioembolization-delivery-system
#5
Robert Drescher, Philipp Seifert, René Aschenbach, Martin Freesmeyer
No abstract text is available yet for this article.
November 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29055956/enhancement-of-neural-salty-preference-in-obesity
#6
Qiang Li, Rongbing Jin, Hao Yu, Hongmei Lang, Yuanting Cui, Shiqiang Xiong, Fang Sun, Chengkang He, Daoyan Liu, Hongbo Jia, Xiaowei Chen, Sijiao Chen, Zhiming Zhu
BACKGROUND/AIMS: Obesity and high salt intake are major risk factors for hypertension and cardiometabolic diseases. Obese individuals often consume more dietary salt. We aim to examine the neurophysiologic effects underlying obesity-related high salt intake. METHODS: A multi-center, random-order, double-blind taste study, SATIETY-1, was conducted in the communities of four cities in China; and an interventional study was also performed in the local community of Chongqing, using brain positron emission tomography/computed tomography (PET/CT) scanning...
October 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29055836/assessment-of-psma-targeting-ligands-bearing-novel-chelates-with-application-to-theranostics-stability-and-complexation-kinetics-of-68-ga-3-111-in-3-177-lu-3-and-225-ac-3
#7
James M Kelly, Alejandro Amor-Coarasa, Anastasia Nikolopoulou, Dohyun Kim, Clarence Williams, Shankar Vallabhajosula, John W Babich
INTRODUCTION: Recent successes in the treatment of metastatic castration-resistant prostate cancer (mCRPCa) by systemic endoradiotherapy has sparked renewed interest in developing small molecule ligands targeting prostate-specific membrane antigen (PSMA) and chelators capable of stable complexation of metal radionuclides for imaging and therapy. As the size and coordination number of metals for imaging, such as (68)Ga(3+), and for targeted therapy, such as (177)Lu(3+) and (225)Ac(3+), are substantially different, they may show a preference for macrocycles of different denticity...
October 3, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29055799/altered-mglur5-binding-potential-and-glutamine-concentration-in-the-6-ohda-rat-model-of-acute-parkinson-s-disease-and-levodopa-induced-dyskinesia
#8
Melissa Crabbé, Anke Van der Perren, Akila Weerasekera, Uwe Himmelreich, Veerle Baekelandt, Koen Van Laere, Cindy Casteels
Several lines of evidence point to alterations in glutamatergic signaling in Parkinson's disease (PD) and levodopa-induced dyskinesia (LID), involving the metabotropic glutamate receptor type 5 (mGluR5). Using small-animal positron emission tomography (PET) with [(18)F]FPEB and proton magnetic resonance spectroscopy, we investigated cerebral changes in the mGluR5 and glutamate/glutamine availability in vivo in PD rats and following onset of LIDs. In parallel, behavioral tests were performed. Comparing PD to control rats, mGluR5 binding potential was decreased in a cluster comprising the bilateral caudate-putamen (CP), ipsilateral motor cortex and somatosensory cortex, and the contralateral somatosensory cortex and parietal association cortex, with the most pronounced reduction in the ipsilateral CP...
September 21, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29055634/additional-diagnostic-value-of-combined-angio-computed-tomography-and-fluorodeoxyglucose-f-18-positron-emission-tomography-in-infectious-aortitis
#9
Nidaa Mikail, Khadija Benali, Antoine Dossier, Claire Bouleti, Fabien Hyafil, Dominique Le Guludec, François Rouzet, Phalla Ou
No abstract text is available yet for this article.
October 14, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29055628/visceral-adiposity-in-psoriasis-is-associated-with-vascular-inflammation-by-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-beyond-cardiometabolic-disease-risk-factors-in-an-observational-cohort-study
#10
Joshua P Rivers, Tiffany M Powell-Wiley, Amit K Dey, Justin A Rodante, Jonathan H Chung, Aditya A Joshi, Balaji Natarajan, Aparna P Sajja, Abhishek Chaturvedi, Anshuma Rana, Charlotte L Harrington, Heather L Teague, Benjamin N Lockshin, Mark A Ahlman, Jianhua Yao, Martin P Playford, Joel M Gelfand, Nehal N Mehta
OBJECTIVES: We sought to examine the relationship between visceral adipose tissue (VAT) and vascular inflammation (VI) by (18)fluorodeoxyglucose ((18)FDG) positron-emission tomography (PET)/computed tomography (CT) in psoriasis (PSO). Furthermore, we evaluated whether treatment of PSO modulated VAT and VI. BACKGROUND: PSO, a chronic inflammatory skin disease, is associated with VI by (18)FDG PET/CT and increased cardiometabolic risk including adipose tissue dysregulation...
October 14, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29055019/-18-f-fluorothymidine-positron-emission-tomography-informs-the-synergistic-efficacy-of-capecitabine-and-trifluridine-tipiracil-in-colon-cancer
#11
Seog-Young Kim, Jin Hwa Jung, Haeng Jung Lee, Hyunsu Soh, Sang Ju Lee, Seung Jun Oh, Sun Young Chae, Jai Hyuen Lee, Seung Jin Lee, Yong Sang Hong, Tae Won Kim, Dae Hyuk Moon
In cancer therapy, enhanced thymidine uptake by the salvage pathway can bypass dTMP depletion, thereby conferring resistance to thymidylate synthase inhibition. We investigated whether sequential combination therapy of capecitabine and trifluridine/tipiracil (TAS-102) could synergistically enhance antitumor efficacy in colon cancer xenograft models. We also examined 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) positron emission tomography (PET) as a means to predict therapeutic response to a sequential combination of capecitabine and trifluridine/tipiracil...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29054675/evidence-of-fatigue-disordered-sleep-and-peripheral-inflammation-but-not-increased-brain-tspo-expression-in-seasonal-allergy-a-11-c-pbr28-pet-study
#12
Sandra Tamm, Simon Cervenka, Anton Forsberg, Johanna Estelius, Johan Grunewald, Pär Gyllfors, Bianka Karshikoff, Eva Kosek, Jon Lampa, Catarina Lensmar, Victoria Strand, Torbjörn Åkerstedt, Christer Halldin, Martin Ingvar, Caroline Olgart Höglund, Mats Lekander
Allergy is associated with non-specific symptoms such as fatigue, sleep problems and impaired cognition. One explanation could be that the allergic inflammatory state includes activation of immune cells in the brain, but this hypothesis has not been tested in humans. The aim of the present study was therefore to investigate seasonal changes in the glial cell marker translocator protein (TSPO), and to relate this to peripheral inflammation, fatigue and sleep, in allergy. We examined 18 patients with severe seasonal allergy, and 13 healthy subjects in and out-of pollen season using positron emission tomography (n = 15/13) and the TSPO radioligand [(11)C]PBR28...
October 17, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29053874/tau-pathology-and-neurodegeneration-contribute-to-cognitive-impairment-in-alzheimer-s-disease
#13
Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovici
Neuropathological and in vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer's disease spectrum. However, tau pathology is also intimately associated with neurodegeneration and amyloid pathology. The aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with 18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer's disease. We included 40 amyloid-positive patients meeting criteria for mild cognitive impairment due to Alzheimer's disease (n = 5) or probable Alzheimer's disease dementia (n = 35)...
October 7, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053782/seizure-onset-zone-localization-using-postictal-hypoperfusion-detected-by-arterial-spin-labelling-mri
#14
Ismael Gaxiola-Valdez, Shaily Singh, Tefani Perera, Sherry Sandy, Emmy Li, Paolo Federico
Neurological dysfunction following epileptic seizures is a well-recognized phenomenon. Several potential mechanisms have been suggested to explain postictal dysfunction, with alteration in cerebral blood flow being one possibility. These vascular disturbances may be long lasting and localized to brain areas involved in seizure generation and propagation, as supported by both animal and human studies. Therefore, measuring perfusion changes in the postictal period may help localize the seizure onset zone. Arterial spin labelling is a non-invasive, rapid and reproducible magnetic resonance imaging technique that measures cerebral perfusion...
September 28, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053775/neuroinflammation-and-its-relationship-to-changes-in-brain-volume-and-white-matter-lesions-in-multiple-sclerosis
#15
Gourab Datta, Alessandro Colasanti, Eugenii A Rabiner, Roger N Gunn, Omar Malik, Olga Ciccarelli, Richard Nicholas, Eline Van Vlierberghe, Wim Van Hecke, Graham Searle, Andre Santos-Ribeiro, Paul M Matthews
Brain magnetic resonance imaging is an important tool in the diagnosis and monitoring of multiple sclerosis patients. However, magnetic resonance imaging alone provides limited information for predicting an individual patient's disability progression. In part, this is because magnetic resonance imaging lacks sensitivity and specificity for detecting chronic diffuse and multi-focal inflammation mediated by activated microglia/macrophages. The aim of this study was to test for an association between 18 kDa translocator protein brain positron emission tomography signal, which arises largely from microglial activation, and measures of subsequent disease progression in multiple sclerosis patients...
September 23, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053416/imaging-of-integrin-%C3%AE-v%C3%AE-3-expression-in-lung-cancers-and-brain-tumors-using-single-photon-emission-computed-tomography-with-a-novel-radiotracer-99m-tc-ida-d-c-rgdfk-2
#16
Yoo Sung Song, Hyun Soo Park, Byung Chul Lee, Jae Ho Jung, Ho-Young Lee, Sang Eun Kim
Integrin αvβ3 is a molecular marker for the estimation of tumor angiogenesis and is an imaging target for radiolabeled Arg-Gly-Asp (RGD) peptides. In this study, the authors investigated the clinical efficacy and safety of a novel radiolabeled RGD peptide, (99m)Tc-IDA-D-[c(RGDfK)]2, for the imaging of integrin αvβ3 expression, as a measure of tumor angiogenesis in lung cancers and brain tumors. Five patients with lung cancers and seven with brain tumors underwent (99m)Tc-IDA-D-[c(RGDfK)]2 single-photon emission computed tomography (SPECT) imaging...
October 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29052535/large-cell-neuroendocrine-carcinoma-of-the-kidney-with-cardiac-metastasis-a-case-report
#17
Moeka Shimbori, Kimito Osaka, Takashi Kawahara, Ryo Kasahara, Sayuki Kawabata, Kazuhide Makiyama, Keiichi Kondo, Noboru Nakaigawa, Shoji Yamanaka, Masahiro Yao
BACKGROUND: Primary large cell neuroendocrine carcinoma of the kidney is a rare and generally very aggressive disease. We present a case of a patient with primary large cell neuroendocrine carcinoma of the kidney with cardiac metastasis. CASE PRESENTATION: A 59-year-old Japanese man presented to his previous physician with hematuria. Computed tomography revealed masses in the heart and right kidney, and fluorodeoxyglucose-positron emission tomography showed abnormal uptake in the heart...
October 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29052526/cardiac-magnetic-resonance-imaging-indeterminate-negative-cardiac-sarcoidosis-revealed-by-18-f-fluorodeoxyglucose-positron-emission-tomography-two-case-reports-and-a-review-of-the-literature
#18
S C Sasson, R Russo, T Chung, G Chu, I Hunyor, J Williamson, A Murad, A Kane, S Riminton, S Limaye
BACKGROUND: Sarcoidosis is an inflammatory disorder of immune dysregulation characterized by non-caseating granulomas that can affect any organ. Cardiac sarcoidosis is an under-recognized entity that has a heterogeneous presentation and may occur independently or with any severity of systemic disease. Diagnosing cardiac sarcoidosis remains problematic with endomyocardial biopsies associated with a high risk of complications. Several diagnostic algorithms are currently available that rely on histopathology or clinical and radiological measures...
October 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29051991/radiation-induced-liver-injury-mimicking-liver-metastases-on-fdg-pet-ct-after-chemoradiotherapy-for-esophageal-cancer-a%C3%A2-retrospective-study-and-literature-review
#19
Francine E M Voncken, Berthe M P Aleman, Jolanda M van Dieren, Cecile Grootscholten, Ferry Lalezari, Johanna W van Sandick, Jeffrey D Steinberg, Erik Vegt
BACKGROUND: For esophageal cancer patients treated with neoadjuvant chemoradiotherapy (nCRT), restaging using F‑18-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET-CT) following nCRT can detect interval metastases, including liver metastases, in almost 10% of patients. However, in clinical practice, focal FDG liver uptake, unrelated to liver metastases, is observed after chemoradiotherapy. This radiation-induced liver injury (RILI) can potentially lead to overstaging...
October 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29051933/peptide-based-fibrin-targeting-probes-for-thrombus-imaging
#20
Bruno L Oliveira, Peter Caravan
The development of new methods to image the onset and progression of thrombosis is an unmet need. Non-invasive molecular imaging techniques targeting specific key structures involved in the formation of thrombosis have demonstrated the ability to detect thrombus in different disease state models and in patients. Due to its high concentration in the thrombus and its essential role in thrombus formation, the detection of fibrin is an attractive strategy for identification of thrombosis. Herein we provide an overview of recent and selected fibrin-targeted probes for molecular imaging of thrombosis by magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), and optical techniques...
October 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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