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https://www.readbyqxmd.com/read/29679299/impact-of-computer-aided-ct-and-pet-analysis-on-non-invasive-t-staging-in-patients-with-lung-cancer-and-atelectasis
#1
Paul Flechsig, Ramin Rastgoo, Clemens Kratochwil, Ole Martin, Tim Holland-Letz, Alexander Harms, Hans-Ulrich Kauczor, Uwe Haberkorn, Frederik L Giesel
PURPOSE: Tumor delineation within an atelectasis in lung cancer patients is not always accurate. When T staging is done by integrated 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG)-positron emission tomography (PET)/X-ray computer tomography (CT), tumors of neuroendocrine differentiation and slowly growing tumors can present with reduced FDG uptake, thus aggravating an exact T staging. In order to further exhaust information derived from [18 F]FDG-PET/CT, we evaluated the impact of CT density and maximum standardized uptake value (SUVmax) for the classification of different tumor subtypes within a surrounding atelectasis, as well as possible cutoff values for the differentiation between the primary tumor and atelectatic lung tissue...
April 20, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29679113/increased-evidence-for-the-prognostic-value-of-fdg-uptake-on-late-treatment-pet-in-non-tumour-affected-oesophagus-in-irradiated-patients-with-oesophageal-carcinoma
#2
Yimin Li, Frank Hofheinz, Christian Furth, Chen Lili, Wu Hua, Pirus Ghadjar, Sebastian Zschaeck
PURPOSE: 18 F-FDG uptake in irradiated non-tumour-affected oesophagus (NTO) on restaging PET is a potential surrogate for the measurement of radiation-induced inflammation. Radiation-induced inflammation itself has been shown to be of high prognostic relevance in patients undergoing preoperative radiochemotherapy (RCT) for locally advanced oesophageal cancer. We assessed the prognostic relevance of FDG uptake in the NTO in an independent cohort of patients treated with definitive RCT...
April 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29679112/post-treatment-positron-emission-tomography-computed-tomography-is-highly-predictive-of-outcome-in-plasmablastic-lymphoma
#3
Yassine Al Tabaa, Emmanuelle Tchernonog, Pierre Faurie, Anne Ségolène Cottereau, Hélène Monjanel, Antoine Bonnet, Steven Le Gouill, Emmanuel Gyan, Hervé Ghesquieres, Denis Mariano-Goulart, Guillaume Cartron
PURPOSE: Plasmablastic lymphoma (PBL) is a rare variant of diffuse large B cell lymphomas (DLBCL) clinically characterized by a poorer prognostic. Few clinical and imaging data are available and derived from pooled case reports and small series. The aim of the study was to evaluate the FDG avidity at baseline and the utility of 18-Fluorodeoxyglucose (FDG) positron-emission-tomography/computed-tomography (PET/CT) for staging and response assessment. METHODS: Patients with newly diagnosed PBL seen at Lymphoma Study Association centers during the period 2005-2015 were included if they underwent a PET/CT at staging and at the end of treatment (eotPET) and had received an anthracycline-based first line therapy...
April 20, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29679108/fluorodeoxyglucose-positron-emission-tomography-imaging-for-diagnosing-periprosthetic-hip-infection-the-importance-of-diagnostic-criteria
#4
Steven J Verberne, Olivier P P Temmerman, Ben Hai Vuong, Pieter G Raijmakers
BACKGROUND: Fluorodeoxyglucose positron emission tomography (FDG-PET) is a novel method of assessing suspected periprosthetic hip infection. However, a heterogeneity of sensitivity and specificity using different diagnostic criteria across clinical studies has been published. The objective of this study is to evaluate the various diagnostic criteria using FDG-PET in diagnosing periprosthetic hip infection. METHODS: FDG-PET scans of patients suffering from painful hip prostheses between 2008 and 2015 were retrospectively reviewed...
April 20, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29678145/evaluation-of-pet-and-laparoscopy-in-staging-advanced-gastric-cancer-a-multicenter-prospective-study-plastic-study
#5
H J F Brenkman, E C Gertsen, E Vegt, R van Hillegersberg, M I van Berge Henegouwen, S S Gisbertz, M D P Luyer, G A P Nieuwenhuijzen, J J B van Lanschot, S M Lagarde, W O de Steur, H H Hartgrink, J H M B Stoot, K W E Hulsewe, E J Spillenaar Bilgen, M J van Det, E A Kouwenhoven, D L van der Peet, F Daams, J W van Sandick, N C T van Grieken, J Heisterkamp, B van Etten, J W Haveman, J P Pierie, F Jonker, A Y Thijssen, E J T Belt, P van Duijvendijk, E Wassenaar, H W M van Laarhoven, F J Wessels, N Haj Mohammad, H F van Stel, G W J Frederix, P D Siersema, J P Ruurda
BACKGROUND: Initial staging of gastric cancer consists of computed tomography (CT) and gastroscopy. In locally advanced (cT3-4) gastric cancer, fluorodeoxyglucose positron emission tomography with CT (FDG-PET/CT or PET) and staging laparoscopy (SL) may have a role in staging, but evidence is scarce. The aim of this study is to evaluate the impact and cost-effectiveness of PET and SL in addition to initial staging in patients with locally advanced gastric cancer. METHODS: This prospective observational cohort study will include all patients with a surgically resectable, advanced gastric adenocarcinoma (cT3-4b, N0-3, M0), that are scheduled for treatment with curative intent after initial staging with gastroscopy and CT...
April 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29677642/diagnostic-value-of-18-f-fluordesoxyglucose-positron-emission-tomography-for-patients-with-brain-metastasis-from-unknown-primary-site
#6
Fabian Wolpert, Michael Weller, Anna Sophie Berghoff, Elisabeth Rushing, Lisa Michaela Füreder, Gregory Petyt, Henning Leske, Nicolaus Andratschke, Luca Regli, Marian Christoph Neidert, Roger Stupp, Rolf Stahel, Reinhard Dummer, Thomas Frauenfelder, Patrick Roth, Nicolas Reyns, Philipp Antonio Kaufmann, Matthias Preusser, Emilie Le Rhun
BACKGROUND: In 30% of patients with brain metastasis (BM), neurological symptoms are the first clinical manifestation of systemic malignancy, referred to as BM from cancer of unknown primary site (BM-CUPS). Here, we define the diagnostic value of 18 F-fluordesoxyglucose positron emission tomography (FDG-PET/CT) in the workup of BM-CUPS. METHODS: We screened 565 patients operated for BM at the University Hospital Zurich and identified 64 patients with BM-CUPS with data on both FDG-PET/CT and contrast-enhanced chest/abdomen computed tomography (CT) available at BM diagnosis...
April 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29675104/prognostic-value-of-bone-marrow-fdg-uptake-pattern-of-pet-ct-in-newly-diagnosed-diffuse-large-b-cell-lymphoma
#7
Yumei Chen, Mingge Zhou, Jianjun Liu, Gang Huang
Purpose: The value of 18 F-fluorodeoxyglucose positron emission tomography /computed tomography (18 F-FDG PET/CT) in assessing bone marrow involvement (BMI) of lymphoma remains controversial. The present study aims to evaluate the prognostic meaning of bone marrow FDG uptake pattern in PET/CT of newly diagnosed diffuse large B-cell lymphoma (DLBCL) patients. Materials and Methods: 193 newly diagnosed DLBCL patients were retrospectively analyzed. All patients received 6-8 cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29674423/now-is-the-time-to-use-fdg-pet-ct-to-optimize-neoadjuvant-treatment-in-triple-negative-breast-cancer
#8
David Groheux
No abstract text is available yet for this article.
April 19, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29673674/association-between-18f-fluorodeoxyglucose-pet-ct-and-histological-grade-of-uterine-endometrial-carcinoma
#9
Hiroaki Takagi, Toshiyuki Sasagawa, Takeo Shibata, Hiroshi Minato, Tomoko Takahashi
OBJECTIVE: The incidence of endometrial adenocarcinoma of the uterine corpus has increased in Japan. This study aimed to clarify the relationships between this type of cancer and various data provided by 18F-fluorodeoxyglucose (FDG) accumulation in positron emission tomography/computed tomography (PET/CT). MATERIALS AND METHODS: The study cohort thus comprised 27 patients with endometrial adenocarcinoma who had undergone PET/CT examinations from April 2008 to March 2015...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673292/relationship-between-inflammation-and-progression-of-an-abdominal-aortic-aneurysm-in-a-rabbit-model-based-on-18f-fdg-pet-ct-imaging
#10
Mao-Xiao Nie, Xue-Hui Zhang, Yun-Feng Yan, Quan-Ming Zhao
Objective To explore the relationship between abdominal aortic aneurysm development and inflammation in the rabbit through the establishment of a rabbit infrarenal abdominal aortic aneurysm model and the use of 18F-FDG PET/CT imaging. Methods Twenty male New Zealand rabbits were administered an elastase intracavity perfusion to induce an infrarenal abdominal aortic aneurysm model. Prior to surgery, the rabbits underwent abdominal aorta ultrasonic testing and blood collection from the ear veins. Of the original 20 rabbits, 10 rabbits were euthanized two weeks after the operation following ultrasonic testing, PET/CT scanning and blood collection, and their arterial tissue samples were prepared for pathological and immunohistochemical staining...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29672466/a-comparative-study-of-quantitative-assessment-with-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-and-endoscopic-ultrasound-in-oesophageal-cancer
#11
Aditya Borakati, Abdul Razack, Chris Cawthorne, Rajarshi Roy, Sharjeel Usmani, Najeeb Ahmed
OBJECTIVES: This study aims to assess the correlation between PET/CT and endoscopic ultrasound (EUS) parameters in patients with oesophageal cancer. PATIENTS AND METHODS: All patients who had complete PET/CT and EUS staging performed for oesophageal cancer at our centre between 2010 and 2016 were included. Images were retrieved and analysed for a range of parameters including tumour length, volume and position relative to the aortic arch. RESULTS: Seventy patients were included in the main analysis...
April 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29672465/lactate-dehydrogenase-levels-and-18f-fdg-pet-ct-metrics-differentiate-between-mediastinal-hodgkin-s-lymphoma-and-primary-mediastinal-b-cell-lymphoma
#12
Rayan H M Alkhawtani, Walter Noordzij, Andor W J M Glaudemans, Rozemarijn S van Rijn, Hilde T van der Galiën, Hans Balink, Marcel Nijland, Hugo J A Adams, Gerwin Huls, Tom van Meerten, Thomas C Kwee
PURPOSE: This study aims to investigate whether clinical, laboratory, and fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT findings can discriminate between mediastinal Hodgkin's lymphoma and primary mediastinal B-cell lymphoma (PMBCL). PATIENTS AND METHODS: This retrospective study included 56 patients (42 with mediastinal Hodgkin's lymphoma and 14 with PBMCL). Differences in clinical, laboratory, and F-FDG PET/CT metrics were assessed between Hodgkin's lymphoma and PMBCL...
April 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29672464/effects-of-breathing-motion-on-pet-acquisitions-step-and-shoot-versus-continuous-bed-motion
#13
Yoshiki Owaki, Tadaki Nakahara, Takeshi Shimizu, Anne M Smith, Wing K Luk, Kazumasa Inoue, Masahiro Fukushi, Kiyotaka Nakajima
OBJECTIVES: Continuous bed motion (CBM) acquisition recently became available in whole-body PET/CT scanners in addition to the conventional step and shoot (S&S) acquisition. In this work, we compared the image quality between these acquisition methods using a phantom simulating periodic motion to mimic motion from patient breathing in a controlled manner. METHODS: PET image quality was assessed using the National Electrical Manufacturers Association IQ torso phantom filled with an F-FDG solution using a 4 : 1 target-to-background ratio...
April 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29672463/limited-additional-value-of-cervical-ultrasonography-over-a-negative-18f-fdg-pet-ct-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-esophageal-cancer-a-systematic-review-and-meta-analysis
#14
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Gert J Meijer, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVE: To assess the additional value of cervical ultrasonography as supplement to a negative fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) for detecting cervical lymph node metastases during the initial staging of patients with esophageal cancer. METHODS: PubMed/Medline, Embase, and the Cochrane library were systematically searched. The analysis included diagnostic studies describing the accuracy of cervical ultrasonography and integrated F-FDG PET/CT or standalone F-FDG PET and CT for detecting cervical lymph node metastases in patients with esophageal cancer...
April 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29672310/significance-of-fdg-pet-hypermetabolism-in-children-with-intractable-focal-epilepsy
#15
Solon Schur, Victoria Allen, Andrew White, David Mirsky, Nicholas Stence, Brent O'Neill, Michael Handler, Roy Dudley, Pramote Laoprasert
BACKGROUND: Interictal 18F-fluorodeoxyglucose-positron emission topography (FDG-PET) hypometabolism is routinely used in the presurgical workup of children with medically intractable epilepsy (MIE). FDG-PET hypermetabolism, however, is rarely seen, and the significance of this finding in the epilepsy workup is not well established. METHODS: We performed a retrospective study of patients who underwent FDG-PET during the presurgical workup of MIE over a 4-year period, between 1 January 2010 and 31 December 2013, at the Children's Hospital Colorado, CO, USA...
April 19, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29671193/diagnostic-performance-of-18-f-fdg-pet-ct-and-whole-body-mri-before-and-early-after-treatment-of-multiple-myeloma-a-prospective-comparative-study
#16
Mohammad Abd Alkhalik Basha, Maged Abdel Gelil Hamed, Rania Refaat, Mohamad Zakarya AlAzzazy, Manar A Bessar, Elshaimaa Mohamed Mohamed, Ayman F Ahmed, Heba Fathy Tantawy, Khaled Mohamed Altaher, Ahmed Ali Obaya, Amira Hamed Mohamed Afifi
OBJECTIVE: To determine the diagnostic accuracy of WB-MRI and 18 F-FDG PET/CT in detecting infiltration pattern, disease activity, and response to treatment in patients with multiple myeloma (MM). MATERIALS AND METHODS: Fifty-six patients with confirmed MM were included in the present study for pre-treatment evaluation. Among these individuals, 22 patients were available for the post-treatment evaluation of response to therapy. All patients were imaged with both WB-MRI and 18 F-FDG PET/CT...
April 18, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29671039/three-days-of-high-dose-glucocorticoid-treatment-attenuates-large-vessel-18f-fdg-uptake-in-large-vessel-giant-cell-arteritis-but-with-a-limited-impact-on-diagnostic-accuracy
#17
Berit Dalsgaard Nielsen, Lars Christian Gormsen, Ib Tønder Hansen, Kresten Krarup Keller, Philip Therkildsen, Ellen-Margrethe Hauge
PURPOSE: To evaluate the in-treatment diagnostic accuracy of FDG PET/CT in large-vessel giant cell arteritis (LV-GCA) by serial scans before and after a short course of high-dose glucocorticoid treatment. METHODS: Twenty-four glucocorticoid-naïve patients with new-onset PET/CT verified LV-GCA (pre-treatment baseline PET) were prospectively included. Excluded were patients with a previous history of GCA or polymyalgia rheumatica, LV-GCA-mimicking conditions and patients on immunosuppressive therapy...
April 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29671038/-18-f-fdg-pet-and-high-resolution-mri-co-registration-for-pre-surgical-evaluation-of-patients-with-conventional-mri-negative-refractory-extra-temporal-lobe-epilepsy
#18
Yao Ding, Yuankai Zhu, Biao Jiang, Yongji Zhou, Bo Jin, Haifeng Hou, Shuang Wu, Junming Zhu, Zhong Irene Wang, Chong H Wong, Meiping Ding, Hong Zhang, Shuang Wang, Mei Tian
PURPOSE: Epilepsy that originates outside of the temporal lobe can present some of the most challenging problems for surgical therapy, especially for patients with conventional magnetic resonance imaging (MRI)-negative refractory extra-temporal lobe epilepsy (ETLE). This study aimed to evaluate the clinical value of pre-surgical 18 F-fluoro-deoxy-glucose positron emission tomography (18 F-FDG PET) and high-resolution MRI (HR-MRI) co-registration in patients with conventional MRI-negative refractory ETLE, and compare their surgical outcomes...
April 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29670497/comparing-the-differential-diagnostic-values-of-18-f-alfatide-ii-pet-ct-between-tuberculosis-and-lung-cancer-patients
#19
Xiaoqing Du, Yu Zhang, Liping Chen, Baoming Mi, Qingjun You, Yuping Xu, Donghui Pan, Weixing Wan, Min Yang, Chunjing Yu
Purpose: To compare the differential diagnostic values of 18 F-Alfatide II PET/CT between tuberculosis and lung cancer patients and in patients with sarcoidosis and common inflammation. Methods: Nine inflammation patients (4 tuberculosis, 3 sarcoidosis, and 2 common inflammation) and 11 lung cancer patients were included in this study. All patients underwent 18 F-FDG and 18 F-Alfatide II PET/CT within 2 weeks, followed by biopsy and surgery. The maximized standard uptake value (SUVmax) and the mean standard uptake value (SUVmean) were evaluated...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29669944/neutrophil-subsets-and-their-gene-signature-associate-with-vascular-inflammation-and-coronary-atherosclerosis-in-lupus
#20
Philip M Carlucci, Monica M Purmalek, Amit K Dey, Yenealem Temesgen-Oyelakin, Simantini Sakhardande, Aditya A Joshi, Joseph B Lerman, Alice Fike, Michael Davis, Jonathan H Chung, Martin P Playford, Mohammad Naqi, Pragnesh Mistry, Gustavo Gutierrez-Cruz, Stefania Dell'Orso, Faiza Naz, Taufiq Salahuddin, Balaji Natarajan, Zerai Manna, Wanxia L Tsai, Sarthak Gupta, Peter Grayson, Heather Teague, Marcus Y Chen, Hong-Wei Sun, Sarfaraz Hasni, Nehal N Mehta, Mariana J Kaplan
BACKGROUND: Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham risk score (FRS). Immune dysregulation associated to a distinct subset of lupus proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in conferring enhanced CV risk. This study assessed if lupus LDGs are associated with in vivo vascular dysfunction and inflammation and coronary plaque. METHODS: SLE subjects and healthy controls underwent multimodal phenotyping of vascular disease by quantifying vascular inflammation (18F-fluorodeoxyglucose-PET/CT [18F-FDG-PET/CT]), arterial dysfunction (EndoPAT and cardio-ankle vascular index), and coronary plaque burden (coronary CT angiography)...
April 19, 2018: JCI Insight
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