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Verónica Vidal, Cristina Albiach, Josep Gradolí, José Leandro Pérez, Vicente Montagud, Joaquina Belchí, Salvador Morell, Lorenzo Fácila
Prosthetic valve endocarditis is a major diagnostic challenge in clinical practice, due to the lower sensitivity of the modified Duke criteria and a higher percentage of cases with negative or inconclusive echocardiography results. The delay in establishing medical and surgical treatment increases the morbidity/mortality rate. New imaging techniques and 18F-FDG PET/CT in particular have meant a significant advance in cases of high clinical suspicion and negative or inconclusive echocardiography, increasing the overall sensitivity of the modified Duke criteria...
June 19, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Kartikeya Rajdev, Abdul Hasan Siddiqui, Shivika Agarwal, Yusra Ansari, Rabih Maroun
Colorectal carcinoma is one of the most common and significant causes of cancer-related death. Metastasis to mediastinal lymph nodes and/or pleura without liver or lung involvement is an atypical pattern of colon cancer metastasis. A 70-year-old male underwent curative right side hemicolectomy and omentectomy for ascending colon cancer followed by adjuvant chemotherapy. Around nine months after surgery, the patient was noted to have bilateral large pleural effusions on the restaging computed tomography scan of the chest/abdomen/pelvis...
January 1, 2018: Journal of Oncology Pharmacy Practice
Valentina Di Liberto, R Maarten van Dijk, Matthias Brendel, Ann-Marie Waldron, Christina Möller, Ines Koska, Isabel Seiffert, Fabio Gualtieri, Franz Josef Gildehaus, Barbara von Ungern-Sternberg, Magdalena Lindner, Sibylle Ziegler, Rupert Palme, Rainer Hellweg, Peter Gass, Peter Bartenstein, Heidrun Potschka
Psychiatric comorbidities are prevalent in patients with epilepsy and greatly contribute to the overall burden of disease. The availability of reliable biomarkers to diagnose epilepsy-associated comorbidities would allow for effective treatment and improved disease management. Due to their non-invasive nature, molecular imaging techniques such as positron emission tomography (PET) are ideal tools to measure pathologic changes. In the current study we investigated the potential of [18 F]fluoro-2-deoxy-d-glucose ([18 F]FDG) and 2'-methoxyphenyl-(N-2'-pyridinyl)-p-18 F-fluoro-benzamidoethylpiperazine ([18 F]MPPF) as imaging correlates of neurobehavioral comorbidities in the pilocarpine rat model of epilepsy...
June 19, 2018: Neurobiology of Disease
Anderson V Catarina, Carolina Luft, Samuel Greggio, Gianina T Venturin, Fernanda Ferreira, Eduardo P Marques, Letícia Rodrigues, Krista Wartchow, Marina C Leite, Carlos A Gonçalves, Angela T S Wyse, Jaderson C Da Costa, Jarbas R De Oliveira, Gisele Branchini, Fernanda B Nunes
Sepsis is one of the main causes of hospitalization and mortality in Intensive Care Units. One of the first manifestations of sepsis is encephalopathy, reported in up to 70% of patients, being associated with higher mortality and morbidity. The factors that cause sepsis-associated encephalopathy (SAE) are still not well known, and may be multifactorial, as perfusion changes, neuroinflammation, oxidative stress and glycolytic metabolism alterations. Fructose-1,6-bisphosphate (FBP), a metabolite of the glycolytic route, has been reported as neuroprotective agent...
June 19, 2018: Brain Research
Flavio Nobili, Javier Arbizu, Femke Bouwman, Alexander Drzezga, Federica Agosta, Peter Nestor, Zuzana Walker, Marina Boccardi
BACKGROUND: Recommendations for using FDG-PET to support the diagnosis of dementing neurodegenerative disorders are sparse and poorly structured. METHODS: We defined 21 questions on diagnostic issues and on semi-automated analysis to assist visual reading. Literature was reviewed to assess study design, risk of bias, inconsistency, imprecision, indirectness and effect size. Critical outcomes were sensitivity, specificity, accuracy, positive/negative predictive value, area under the receiving operating characteristic curve, and positive/negative likelihood ratio of FDG-PET in detecting the target conditions...
June 22, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Valeria Isella, Stefano Giuseppe Grisanti, Francesca Ferri, Sabrina Morzenti, Cinzia Crivellaro, Monica Musarra, Carlo Ferrarese
BACKGROUND: Cognitively stimulating life experiences and activities are deemed to moderate the clinical impact of brain damage progressively building a neural and cognitive reserve (CR). CR has been studied extensively in various neurodegenerative disorders, but not in Corticobasal degeneration (CBD). METHODS: Using SPM8 we correlated years of education, as determinant of cognitive reserve, with tracer uptake on FDG-PET, as marker of neurodegeneration, in 35 patients with various phenotypes of CBD, including a cognitive-motor composite score or symptoms duration as covariates for controlling disease stage...
June 22, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Alexey Surov, Hans Jonas Meyer, Anne-Kathrin Höhn, Karsten Winter, Osama Sabri, Sandra Purz
PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is one of common cancers worldwide. Positron emission tomography (PET) with 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) is increasingly used for diagnosing and staging, as well as for monitoring of treatment of HNSCC. PET parameters like maximum and mean standard uptake values (SUVmax , SUVmean ) can predict the behavior of HNSCC. The purpose of this study was to analyze possible associations between these PET parameters and clinically relevant histopathological features in patients with HNSCC...
June 21, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Hongkai Wang, Ziyu Tan, Qiang Zheng, Jing Yu
This article was updated to correct the spelling of Hongkai Wang's name: it is correct as displayed here.
June 21, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Christopher J Burke, William R Walter, Sushma Gaddam, Hien Pham, James S Babb, Joseph Sanger, Fabio Ponzo
OBJECTIVES: To correlate patterns of 18 F-FDG uptake on whole-body PET-CT with MR findings and compare the degree of FDG activity between symptomatic and asymptomatic knees. MATERIALS AND METHODS: Retrospective database query was performed using codes for knee MRI as well as whole-body PET-CT. Patients with malignant disease involving the knee or hardware were excluded. Patients who had both studies performed within 1 year between 2012 and 2017 were included for analysis...
June 21, 2018: Skeletal Radiology
Malgorzata Wrzesien
The production of radiopharmaceuticals for the needs of positron emission tomography (PET), in particular 18F-FDG, is a multi-step process performed most often by physicists and chemists. The monitoring of occupational exposure of staff employed in radiopharmaceutical production centres includes the measurement of the Hp(10) and Hp(0.07) values. Occupational exposure to ionising radiation means that the thyroid may be, among others, affected by the radiation field. This work analyses the exposure of the thyroid gland of employees of centres that produce the isotopes for PET, in particular fluorine-18...
June 20, 2018: Radiation Protection Dosimetry
Lei Jiang, Yan Huang, Qiying Tang, Qingping Zhao, Yuan Li, Xiaodong Wu, Huoqiang Wang
The radiological features of pulmonary sclerosing hemangioma (PSH) and pulmonary hamartoma are poorly specified. Thus, the present study aimed to compare and analyze the characteristics of fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) in PSH versus pulmonary hamartoma. 18 F-FDG PET/CT characteristic findings of 12 patients with PSH and 14 patients with pulmonary hamartoma were retrospectively reviewed. A total of 12 lesions were detected from the 12 patients with PSH, of which 3 masses exhibited calcification...
July 2018: Oncology Letters
Nobuyuki Maruyama, Kazuhide Nishihara, Toshiyuki Nakasone, Masanao Saio, Tessho Maruyama, Iori Tedokon, Tetsuya Ohira, Fumikazu Nimura, Akira Matayoshi, Ken-Nosuke Karube, Naoki Yoshimi, Akira Arasaki
Second primary malignancy (SPM) is a severe issue for cancer survivors, particularly for osteosarcoma (OS) survivors. To date, the associations between subsequent SPM and OS have been well reported. Hematogenic and solid malignancies tend to occur following OS treatment. Reportedly, 2-[18 F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) is mainly used in OS patients for initial cancer staging, to evaluate the response of neoadjuvant chemotherapy, and when recurrence or metastasis is clinically suspected...
June 2018: Oncology Letters
Sriram Vaidyanathan, Arpita Chattopadhyay, Sarah L Mackie, Andrew Scarsbrook
OBJECTIVES: Large-vessel vasculitis (LVV) is a serious illness with potentially life-threatening consequences. 18 F-FDG PET-CT has emerged as a valuable diagnostic tool in suspected LVV, combining the strengths of functional and structural imaging. This study aimed to compare the accuracy of FDG PET-CT and contrast-enhanced CT (CECT) in the evaluation of patients with LVV. METHODS: A retrospective database review for LVV patients undergoing CECT and PET-CT between 2011 to 2016 yielded demographics, scan interval and vasculitis type...
June 21, 2018: British Journal of Radiology
Aatif Parvez, Noam Tau, Douglas Hussey, Manjula Maganti, Ur Metser
In the original publication of the article, the title was incorrectly.
June 20, 2018: Annals of Nuclear Medicine
Brendan W Lunn, Laurel A Littrell, Doris E Wenger, Stephen M Broski
OBJECTIVE: To examine the imaging characteristics of intramuscular myxomas (IM) and myxoid liposarcomas (MLS) on 18 F-FDG PET/CT and MRI. MATERIALS AND METHODS: With IRB approval, our institutional imaging database was searched for pathologically proven IM and MLS evaluated by 18 F-FDG PET/CT and MRI. PET/CT and MRI imaging characteristics were recorded and correlated with pathologic diagnosis. RESULTS: We found eight patients (2 M, 6 F) with IM (mean age 65...
June 20, 2018: Skeletal Radiology
Kazuhiro Kitajima, Shingo Yamamoto, Soichi Odawara, Kaoru Kobayashi, Masayuki Fujiwara, Norihiko Kamikonya, Kazuhito Fukushima, Yukako Nakanishi, Takahiko Hashimoto, Yusuke Yamada, Toru Suzuki, Akihiro Kanematsu, Michio Nojima, Koichiro Yamakado
We compared 11C-choline and FDG PET/CT scan findings for the staging and restaging of prostate cancer. Twenty Japanese prostate cancer patients underwent 11C-choline and FDG PET/CT before (n=5) or after (n=15) treatment. Using a five-point scale, we compared these scanning modalities regarding patient- and lesion-based diagnostic performance for local recurrence, untreated primary tumor, and lymph node and bony metastases. Of the 20 patients, documented local lesions, and node and bony metastases were present in 11 (55...
June 2018: Acta Medica Okayama
Ayaka Ushio, Komei Takauchi, Makoto Kobayashi, Nobukazu Abe, Hiroomi Sumida, Yasushi Nagata, Kazuo Awai
PURPOSE: We examined whether early delayed scanning is useful for differentiation of liver lesion and heterogenous physiological accumulation in positron emission tomography (PET) examination. METHODS: The subjects of the study were 33 patients with colorectal cancer who underwent PET examination and were added early delayed scanning to distinguish between liver lesions and heterogenous physiological accumulation to conventional early images. We placed same regions of interest (ROI) in the tumor and hepatic parenchyma for early delayed and conventional early images...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
Noriaki Miyaji, Kazuki Motegi, Shohei Fukai, Naoki Shimada, Kenta Miwa, Shuto Nakazawa, Takuro Umeda, Tomohiro Takiguchi, Takashi Terauchi, Mitsuru Koizumi
PURPOSE: The AI-300 automated infusion device (Sumitomo Heavy Industries, Ltd., Tokyo, Japan) is subject to administration error as a function of smaller volumes of 18 F-FDG dispensed via a three-way cock supplied with a disposable kit. The present study aimed to validate the administration accuracy of the AI-300 using an improved disposable kit for quantitative positron emission tomography (PET) assessment. METHODS: We determined administration accuracy between the improved and previous disposable kits by measuring variations in dispensed volumes and radioactive concentrations of 18 F-FDG according to the criteria of the Japanese Society of Nuclear Medicine...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
L Dai, H Fu, F Wang, R Guo, Y B Yang, Y Lin, K N Chen
Objective: To evaluate the value of (18)F-FDG PET/CT in predicting long-term survival of esophageal squamous cell carcinoma(ESCC) before initial treatment. Methods: A total of 167 ESCC patients were retrospectively analyzed who underwent surgery between January 2010 and December 2014 in prospective database of Peking University Cancer Hospital Thoracic Surgery Department One, all cases were included according to inclusion and exclusion criteria.The relationship between SUVmax of the primary tumor and patients' age, gender, tumor location, tumor differentiation, tumor regression grade as well as long term survival were compared...
June 5, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Sivanath Reddy Gajjala, Narendra Hulikal, Silpa Kadiyala, Radhika Kottu, Tekchand Kalawat
Background & objectives: Locally advanced breast cancer (LABC) is associated with substantial risk of occult metastases. The patients with LABC have high rate of systemic relapse, suggesting inadequacy of the current conventional staging in detecting the occult metastatic spread. 18 F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is a new modality in the staging of breast cancer patients. Hence, this study was conducted to evaluate the role of 18 F-FDG PET/CT in initial staging of LABC and to compare it with conventional methods...
March 2018: Indian Journal of Medical Research
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