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https://www.readbyqxmd.com/read/28816162/heart-dosimetry-is-correlated-with-risk-of-radiation-pneumonitis-after-lung-sparing-hemithoracic-pleural-intensity-modulated-radiation-therapy-for-malignant-pleural-mesothelioma
#1
Ellen D Yorke, Andrew Jackson, Li Cheng Kuo, Anthonia Ojo, Kelly Panchoo, Prasad Adusumilli, Marjorie G Zauderer, Valerie W Rusch, Annemarie Shepherd, Andreas Rimner
PURPOSE: To determine clinically helpful dose-volume and clinical metrics correlating with symptomatic radiation pneumonitis (RP) in malignant pleural mesothelioma (MPM) patients with 2 lungs treated with hemithoracic intensity modulated pleural radiation therapy (IMPRINT). METHODS AND MATERIALS: Treatment plans and resulting normal organ dose-volume histograms of 103 consecutive MPM patients treated with IMPRINT (February 2005 to January 2015) to the highest dose ≤50...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28814898/reducing-rectal-injury-in-men-receiving-prostate-cancer-radiation-therapy-current-perspectives
#2
REVIEW
Nicholas A Serrano, Noah S Kalman, Mitchell S Anscher
Dose escalation is now the standard of care for the treatment of prostate cancer with radiation therapy. However, the rectum tends to be the dose-limiting structure when treating prostate cancer, given its close proximity. Early and late toxicities can occur when the rectum receives large doses of radiation therapy. New technologies allow for prevention of these toxicities. In this review, we examine the evidence that supports various dose constraints employed to prevent these rectal injuries from occurring...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28811038/fast-and-robust-online-adaptive-planning-in-stereotactic-mr-guided-adaptive-radiation-therapy-smart-for-pancreatic-cancer
#3
O Bohoudi, A M E Bruynzeel, S Senan, J P Cuijpers, B J Slotman, F J Lagerwaard, M A Palacios
BACKGROUND AND PURPOSE: To implement a robust and fast stereotactic MR-guided adaptive radiation therapy (SMART) online strategy in locally advanced pancreatic cancer (LAPC). MATERIAL AND METHODS: SMART strategy for plan adaptation was implemented with the MRIdian system (ViewRay Inc.). At each fraction, OAR (re-)contouring is done within a distance of 3cm from the PTV surface. Online plan re-optimization is based on robust prediction of OAR dose and optimization objectives, obtained by building an artificial neural network (ANN)...
August 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28810879/quantification-of-mutant-spop-proteins-in-prostate-cancer-using-mass-spectrometry-based-targeted-proteomics
#4
Hui Wang, Christopher E Barbieri, Jintang He, Yuqian Gao, Tujin Shi, Chaochao Wu, Athena A Schepmoes, Thomas L Fillmore, Sung-Suk Chae, Dennis Huang, Juan Miguel Mosquera, Wei-Jun Qian, Richard D Smith, Sudhir Srivastava, Jacob Kagan, David G Camp, Karin D Rodland, Mark A Rubin, Tao Liu
BACKGROUND: Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it remains unclear if mutant SPOP proteins can be utilized as biomarkers for early detection, diagnosis, prognosis or targeted therapy of prostate cancer. Moreover, the SPOP mutation sites are distributed in a relatively short region with multiple lysine residues, posing significant challenges for bottom-up proteomics analysis of the SPOP mutations...
August 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28804851/thrombin-generation-assays-tgas
#5
Gian Luca Salvagno, Erik Berntorp
In recent years, there has been a revival of interest in a time-honored tool of the clotting trade: the thrombin generation curve or thrombin generation (TG) assay (TGA) as we now call it. Thrombin generation is a key coagulation process that determines the extent of a hemostatic plug or a thrombotic process. The recent development of newer tests based on the continuous registration of TG under in vitro conditions that mimic more closely what occurs in vivo prompted us to reinvestigate the balance between procoagulants and anticoagulants in patients...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28797299/prevalence-of-antimicrobial-drug-resistant-bacteria-carried-by-in-and-outpatients-attending-a-secondary-care-hospital-in-zambia
#6
Marjolijn M B Nagelkerke, Kapembwa Sikwewa, Dennis Makowa, Irene de Vries, Simon Chisi, J Wendelien Dorigo-Zetsma
OBJECTIVE: Antimicrobial resistance is an increasing global health problem. Very little data on resistance patterns of pathogenic bacteria in low-income countries exist. The aim of this study was to measure the prevalence of antimicrobial drug resistant bacteria carried by in- and outpatients in the resource constraint setting of a secondary care hospital in Zambia. Nasal and rectal samples from 50 in- and 50 outpatients were collected. Patients were randomly selected and informed consent was obtained...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28792165/acute-stylet-peritoneal-dialysis-in-acute-kidney-injury-the-soul-never-dies
#7
Amith Vijay Leon D'Souza, Nishad Raveendran, Rajendra Singh Tanwar, Piyush Kimmatkar, Pankaj Beniwal, Dhananjai Agarwal, Vinay Vinay
BACKGROUND: Acute Kidney Injury (AKI) has a significant mortality rate. In developing countries, mortality due to AKI is high due to lack of access to dialysis facilities and related cost. The main goal of International Society of Nephrology (ISN) 0 by 25 initiative is to eliminate deaths due to AKI. Peritoneal dialysis is an underutilized modality in such a scenario. The aim of this study was to look into effectiveness of starting Acute stylet Peritoneal Dialysis (PD) in a resource constraint settings...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28781797/effect-of-modern-high-quality-prostate-intensity-modulated-radiation-therapy-on-outcome-evidence-from-a-community-radiation-oncology-program
#8
Johnny Kao, Amanda Zucker, Jonathan Timmins, Shankar Taramangalam, Jeffrey Pettit, Aaron J Woodall, Edward Loizides, Andrew T Wong
Radiation technique for prostate cancer has continuously evolved over the past several decades. The aim of the present study was to describe the effects of implementing modern prostate intensity-modulated radiation therapy (M-IMRT) on dosimetry and outcome. Between January 2010 and April 2012, 48 consecutive patients were treated with conventional prostate IMRT (C-IMRT) to a dose of 81 Gy. Between May 2012 and April 2015, 50 consecutive patients were treated with M-IMRT to the entire prostate to a dose of 75...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28774489/-normal-tissue-tolerance-to-external-beam-radiation-therapy-bone-marrow-and-cortical-bone-structures
#9
A Schernberg, C Hennequin
In patients undergoing external radiation therapy, bone marrow and cortical bone structures are all often neglected as organs at risk. Still, from increased febrile neutropenia risk in patients undergoing chemoradiation for a pelvic tumour to increased risk of vertebral fracture when undergoing hypofractioned stereotactic radiotherapy of a spinal metastasis, adverse effects are frequent and sometimes serious. This literature review first defines the rules for contouring these structures, then the dose constraints currently recommended...
July 31, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28770597/can-differentiated-care-models-solve-the-crisis-in-hiv-treatment-financing-analysis-of-prospects-for-38-countries-in-sub-saharan-africa
#10
Catherine Barker, Arin Dutta, Kate Klein
INTRODUCTION: Rapid scale-up of antiretroviral therapy (ART) in the context of financial and health system constraints has resulted in calls to maximize efficiency in ART service delivery. Adopting differentiated care models (DCMs) for ART could potentially be more cost-efficient and improve outcomes. However, no study comprehensively projects the cost savings across countries. We model the potential reduction in facility-level costs and number of health workers needed when implementing two types of DCMs while attempting to reach 90-90-90 targets in 38 sub-Saharan African countries from 2016 to 2020...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28766281/nebulized-antibiotics-in-mechanically-ventilated-patients-a-challenge-for-translational-research-from-technology-to-clinical-care
#11
REVIEW
Stephan Ehrmann, Jean Chastre, Patrice Diot, Qin Lu
Nebulized antibiotic therapy directly targets airways and lung parenchyma resulting in high local concentrations and potentially lower systemic toxicities. Experimental and clinical studies have provided evidence for elevated lung concentrations and rapid bacterial killing following the administration of nebulized antibiotics during mechanical ventilation. Delivery of high concentrations of antibiotics to infected lung regions is the key to achieving efficient nebulized antibiotic therapy. However, current non-standardized clinical practice, the difficulties with implementing optimal nebulization techniques and the lack of robust clinical data have limited its widespread adoption...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28760560/hippocampal-dose-from-stereotactic-radiosurgery-for-4-to-10-brain-metastases-risk-factors-feasibility-of-dose-reduction-via-re-optimization-and-patient-outcomes
#12
Samuel R Birer, Adam C Olson, Justus Adamson, Rodney Hood, Matthew Susen, Grace Kim, Joseph K Salama, John P Kirkpatrick
This study aimed to report hippocampal dose from single-fraction stereotactic radiosurgery (SRS) for 4 to 10 brain metastases and determine feasibility of hippocampal-sparing SRS. Patients with 4 to 10 brain metastases receiving single-isocenter, multi-target single-fraction SRS were identified. Hippocampi were contoured using the Radiation Therapy Oncology Group (RTOG) 0933 atlas. RTOG 0933 dose constraints were converted to a biologically effective dose using an alpha/beta of 2 (D100 421 cGy, Dmax 665 cGy)...
July 28, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28755441/plan-quality-and-delivery-time-comparisons-between-volumetric-modulated-arc-therapy-and-intensity-modulated-radiation-therapy-for-scalp-angiosarcoma-a-planning-study
#13
Yudai Kai, Ryo Toya, Tetsuo Saito, Akiko Kuraoka, Yoshinobu Shimohigashi, Yuji Nakaguchi, Masato Maruyama, Ryuji Murakami, Yasuyuki Yamashita, Natsuo Oya
INTRODUCTION: Due to its spherical surface, scalp angiosarcoma requires careful consideration for radiation therapy planning and dose delivery. Herein, we investigated whether volumetric modulated arc therapy (VMAT) is superior to intensity modulated radiation therapy (IMRT) in terms of the plan quality and delivery time. METHODS: Three different coplanar treatment plans were created for four patients, comprising a two-arc VMAT plan as well as 5-field and 9-field IMRT plans with 6 MV beams...
July 29, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28749618/radiation-induced-second-cancer-risk-from-external-beam-photon-radiotherapy-for-head-and-neck-cancer-impact-on-in-field-and-out-of-field-organs
#14
Vasanthan Sakthivel, Ganesh Kadirampatti Mani, Sunil Mani, Raghavendiran Boopathy
The purpose of this paper is to provide data on development of second primary cancers within or adjacent to tissue irradiated in the treatment of primary head and neck cancers using different techniques and modalities. Materials and methods: We selected five patients with HandN tumors located in base of the tongue for risk assessment. In order to examine the impact of choices of various planning techniques, numbers of beams and beam energy used in treatment plans - 7 and 9 field Intensity modulated radiotherapy (IMRT) plans using 6MV and 10 MV beam energies and a 6MV Volumetric modulated arc therapy (VMAT) plans were planned...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749165/impact-of-robotic-ultrasound-image-guidance-on-plan-quality-in-sbrt-of-the-prostate
#15
Stefan Gerlach, Ivo Kuhlemann, Floris Ernst, Christoph Fürweger, Alexander Schlaefer
OBJECTIVES: Ultrasound provides good image quality, fast volumetric imaging, and is established for abdominal image guidance. Robotic transducer placement may facilitate intra-fractional motion compensation in radiation therapy. We consider integration with the CyberKnife and study whether the kinematic redundancy of a seven-degrees-of-freedom robot allows for acceptable plan quality for prostate treatments. METHODS: Reference treatment plans were generated for ten prostate cancer cases previously treated with the CyberKnife...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28749087/coaction-of-individual-and-environmental-factors-a-review-of-intensive-therapy-paradigms-for-children-with-unilateral-spastic-cerebral-palsy
#16
REVIEW
Claudio L Ferre, Andrew M Gordon
Evidence-based treatment approaches for children with unilateral spastic cerebral palsy are expanding and being modified to fit the constraints of families and the child receiving treatment. In this review, we first provide an overview of a theoretical framework that considers the intricate interactions between the individual child and the environment in which treatment is provided. Next, we describe intensive interventions that have strong support for their efficacy. We also highlight the heterogeneity with which children respond to these approaches...
July 27, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28742245/patients-expectations-on-spinal-cord-stimulation-for-failed-back-surgery-syndrome-a-qualitative-exploration
#17
Dylan J H A Henssen, Nicole Scheepers, Erkan Kurt, Inge Arnts, Monique Steegers, Kris Vissers, Robert van Dongen, Yvonne Engels
BACKGROUND: Spinal cord stimulation (SCS) is an effective therapy to reduce pain in patients that suffer from failed back surgery syndrome (FBSS). In order to inform patients optimally prior to this therapy, knowing their expectations is crucial. METHODS: Thirteen patients suffering from FBSS and scheduled for SCS were interviewed, using a semi-structured protocol. Patients were interviewed either at home or at their treating hospital. Data from these interviews were analyzed using directed content analysis...
July 25, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28741600/coverage-based-constraints-for-imrt-optimization
#18
Henning Mescher, Silke Ulrich, Mark Bangert
Radiation therapy treatment planning requires an incorporation of uncertainties in order to guarantee an adequate irradiation of the tumor volumes. In current clinical practice, uncertainties are accounted for implicitly with an expansion of the target volume according to generic margin recipes. Alternatively, it is possible to account for uncertainties by explicit minimization of objectives that describe worst case treatment scenarios, the expectation value of the treatment, or the coverage probability of the target volumes during treatment planning...
July 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28740908/preplanning-prediction-of-the-left-anterior-descending-artery-maximum-dose-based-on-patient-dosimetric-and-treatment-planning-parameters
#19
Benjamin T Cooper, Xiaochun Li, Samuel M Shin, Aram S Modrek, Howard C Hsu, J K DeWyngaert, Gabor Jozsef, Stella C Lymberis, Judith D Goldberg, Silvia C Formenti
PURPOSE: Maximum dose to the left anterior descending artery (LADmax) is an important physical constraint to reduce the risk of cardiovascular toxicity. We generated a simple algorithm to guide the positioning of the tangent fields to reliably maintain LADmax <10 Gy. METHODS AND MATERIALS: Dosimetric plans from 146 consecutive women treated prone to the left breast enrolled in prospective protocols of accelerated whole breast radiation therapy, with a concomitant daily boost to the tumor bed (40...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28737788/a-multiscale-agent-based-framework-integrated-with-a-constraint-based-metabolic-network-model-of-cancer-for-simulating-avascular-tumor-growth
#20
Mehrdad Ghadiri, Mahshid Heidari, Sayed-Amir Marashi, Seyed Hasan Mousavi
In recent years, many efforts have been made in the field of computational modeling of cancerous tumors, in order to obtain a better understanding and predictions of their growth patterns. Furthermore, constraint-based modeling of metabolic networks has become increasingly popular, which is appropriate for the systems-level reconstruction of cell physiology. The goal of the current study is to integrate a multiscale agent-based modeling framework with a constraint-based metabolic network model of cancer cells in order to simulate the three dimensional early growth of avascular tumors...
July 24, 2017: Molecular BioSystems
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