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https://www.readbyqxmd.com/read/29321569/xeno-free-pre-vascularized-spheroids-for-therapeutic-applications
#1
E Bauman, T Feijão, D T O Carvalho, P L Granja, C C Barrias
Spheroid culture has gained increasing popularity, arising as a promising tool for regenerative medicine applications. Importantly, spheroids may present advantages over single-cell suspensions in cell-based therapies (CT). Unfortunately, most growth media used for spheroid culture contain animal origin-components, such as fetal bovine serum (FBS). The presence of FBS compromises the safety of CT and presents economic and ethical constraints. SCC (supplement for cell culture) is a novel xeno-free (XF) industrial cell culture supplement, derived from well-controlled pooled human plasma and processed under good manufacturing practice rules...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316969/proton-and-helium-ion-radiotherapy-for-meningioma-tumors-a-monte-carlo-based-treatment-planning-comparison
#2
Thomas Tessonnier, Andrea Mairani, Wenjing Chen, Paola Sala, Francesco Cerutti, Alfredo Ferrari, Thomas Haberer, Jürgen Debus, Katia Parodi
BACKGROUND: Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative to proton beams for radiation therapy. Hence, this work aims at comparing in-silico the treatment of brain and ocular meningiomas with protons and helium ions, using for the first time a dedicated Monte Carlo (MC) based treatment planning engine (MCTP) thoroughly validated both in terms of physical and biological models. METHODS: Starting from clinical treatment plans of four patients undergoing proton therapy with a fixed relative biological effectiveness (RBE) of 1...
January 9, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29310903/proton-beam-therapy-for-skull-base-chordomas-in-106-patients-a-dose-adaptive-radiation-protocol
#3
Vivien Fung, Valentin Calugaru, Stéphanie Bolle, Hamid Mammar, Claire Alapetite, Philippe Maingon, Ludovic De Marzi, Sébastien Froelich, Jean-Louis Habrand, Rémi Dendale, Georges Noël, Loïc Feuvret
BACKGROUND AND PURPOSE: To evaluate clinical results and safety of a dose adaptive protocol based on tumor volume coverage and critical structure constraints, for the treatment of skull base chordomas. MATERIAL AND METHODS: Between May 2006 and October 2012, 106 patients with skull base chordoma were treated by combined photon and proton irradiation. Prescribed dose levels were 68.4, 70.2, 72 and 73.8 Gy(RBE) in once daily fractionation of 1.8 Gy(RBE). Dose level and dosimetric constraints to organs at risk depended on postoperative residual Gross Tumor Volume (GTV) coverage...
January 6, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29309346/relationship-between-untimed-plasma-lopinavir-concentrations-and-virological-outcome-on-second-line-antiretroviral-therapy
#4
Gwamaka E Mwasakifwa, Cecilia Moore, Dianne Carey, Janaki Amin, Paul Penteado, Marcelo Losso, Poh-Lian Lim, Lerato Mohapi, Jean-Michel Molina, Brian Gazzard, David A Cooper, Mark Boyd
BACKGROUND: Resource constraints in low and middle-income countries necessitate practical approaches to optimizing antiretroviral therapy outcomes. We hypothesised that an untimed plasma lopinavir concentration (UPLC) at week 12 would predict loss of virological response in those taking lopinavir as part of a second-line antiretroviral regimen. METHODS: We measured plasma lopinavir concentration at week 12 on stored samples from the SECOND-LINE study. We characterized UPLC as: detectable and optimal (≥1000 μg/l); detectable but suboptimal (≥25 to < 1000 μg/l); and undetectable (<25 μg/l)...
January 28, 2018: AIDS
https://www.readbyqxmd.com/read/29306538/comparison-of-calculated-dose-distributions-reported-as-dose-to-water-and-dose-to-medium-for-intensity-modulated-radiotherapy-of-nasopharyngeal-cancer-patients
#5
Ðeni Smilović Radojčić, Manda Švabić Kolacio, Milan Radojčić, David Rajlić, Božidar Casar, Dario Faj, Slaven Jurković
Advanced dose calculation algorithms for radiation therapy treatment planning can report external beam photon dose 2-sided, in terms of dose-to-medium (Dm) and dose-to-water (Dw). The purpose of our study was to determinate the effect of Dw and Dm reporting modes built in Elekta Monaco treatment planning system on intensity-modulated radiotherapy dose distributions for patients with nasopharyngeal cancer. For 13 patients involved in this retrospective study, 2 plans were created: 1 using Dw and another according to Dm reporting mode...
January 4, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29302704/a-randomized-phase%C3%A2-iii-study-between-sequential-versus-simultaneous-integrated-boost-intensity-modulated-radiation-therapy-in-nasopharyngeal-carcinoma
#6
Chawalit Lertbutsayanukul, Anussara Prayongrat, Danita Kannarunimit, Chakkapong Chakkabat, Buntipa Netsawang, Sarin Kitpanit
PURPOSE: This study was performed to compare the acute and late toxicities between sequential (SEQ) and simultaneous integrated boost (SIB) intensity-modulated radiotherapy (IMRT) in nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: Stage I-IVB NPC patients were randomized to receive SEQ-IMRT or SIB-IMRT. SEQ-IMRT consisted of two plans: 2 Gy × 25 fractions to low-risk planning target volume (PTV) followed by a sequential boost (2 Gy × 10 fractions) to high-risk PTV, while SIB-IMRT treated low- and high-risk PTVs with doses of 56 and 70 Gy in 33 fractions...
January 4, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29297102/endovascular-stroke-treatment-on-single-plane-vs-bi-plane-angiography-suites-technical-considerations-and-evaluation-of-treatment-success
#7
Benjamin Friedrich, Christian Maegerlein, Donald Lobsien, Sebastian Mönch, Maria Berndt, Dennis Hedderich, Silke Wunderlich, Dominik Michalski, Manuel Lehm, Tobias Boeckh-Behrens, Claus Zimmer, Kornelia Kreiser
INTRODUCTION: Endovascular stroke therapy is mostly available in comprehensive stroke centers with state of the art bi-plane angiography suites. The aim of the present study was to analyze if it is justifiable to treat patients with alternative x‑ray machines in the case of capacity constraints, or if it is mandatory to refer patients in such cases. Secondly, we wanted to draw conclusions for the feasibility of different logistic approaches in stroke treatment, such as a "helistroke" concept...
January 2, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29295735/photodynamic-therapy-interventions-in-facial-photodamage-a-systematic-review
#8
G Sanclemente, V Ruiz-Cañas, J M Miranda, A P Ferrín, P A Ramirez, G N Hernandez
INTRODUCTION: Photodynamic therapy (PDT) involves the combination of a light source and a photosensitizing agent to induce tissue damage via the generation of singlet oxygen. Although topical PDT has been approved for other indications, its use in facial photodamage is uncertain. AIMS: To assess the efficacy and safety of PDT in facial skin photoaging. METHODS: All randomized clinical trials (RCTs) evaluating the efficacy and safety of any form of topical PDT for the treatment of facial photodamage (dermatoheliosis) or photoaging in patients older than 18 years, were included...
December 30, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29289841/interhemispheric-motor-interactions-in-hemiparetic-children-with-perinatal-stroke-clinical-correlates-and-effects-of-neuromodulation-therapy
#9
Derek Eng, Ephrem Zewdie, Patrick Ciechanski, Omar Damji, Adam Kirton
OBJECTIVE: Brain stimulation and constraint therapy may enhance function after perinatal stroke but mechanisms are unknown. We characterized interhemispheric interactions (IHI) in hemiparetic children and explored their relationship to motor function and neuromodulation. METHODS: Forty-five hemiparetic perinatal stroke subjects aged 6-19 years completed a clinical trial of repetitive-transcranial magnetic stimulation (rTMS) and constraint therapy. Paired-pulse TMS measured IHI in cases and normal controls...
November 26, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29283026/restoring-motor-functions-after-stroke-multiple-approaches-and-opportunities
#10
Estelle Raffin, Friedhelm C Hummel
More than 1.5 million people suffer a stroke in Europe per year and more than 70% of stroke survivors experience limited functional recovery of their upper limb, resulting in diminished quality of life. Therefore, interventions to address upper-limb impairment are a priority for stroke survivors and clinicians. While a significant body of evidence supports the use of conventional treatments, such as intensive motor training or constraint-induced movement therapy, the limited and heterogeneous improvements they allow are, for most patients, usually not sufficient to return to full autonomy...
November 1, 2017: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29281478/assessment-of-treatment-patterns-for-metastatic-renal-cell-carcinoma-in-brazil
#11
Paulo G Bergerot, Cristiane D Bergerot, Nazli Dizman, Stenio Zequi, Andre Fay, Yash Dara, Manuel Caitano Maia, Brendan N Cotta, Edna Prado Gonçalves, Maria Nirvana Formiga, Milena Shizue Tariki, Diego Abreu Clavijo, Toni K Choueiri, Gilberto Lopes, Sumanta K Pal
Background Although multiple therapies have emerged for the treatment of metastatic renal cell carcinoma (mRCC), it is unclear whether application of these agents is consistent in developed and developing countries. We sought to determine patterns of care for mRCC in Brazil as a representative developing country. Material and Methods A commercial database was used to acquire information pertaining to patients with mRCC receiving treatment at private or public hospitals in Brazil between March 2013 and October 2016...
December 27, 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29277446/phase-i-trial-of-stereotactic-mr-guided-online-adaptive-radiation-therapy-smart-for-the-treatment-of-oligometastatic-or-unresectable-primary-malignancies-of-the-abdomen
#12
Lauren Henke, Rojano Kashani, Clifford Robinson, Austen Curcuru, Todd DeWees, Jeffrey Bradley, Olga Green, Jeff Michalski, Sasa Mutic, Parag Parikh, Jeffrey Olsen
PURPOSE/OBJECTIVES: SBRT is used to treat oligometastatic or unresectable primary abdominal malignancies, although ablative dose delivery is limited by proximity of organs-at-risk (OAR). Stereotactic, magnetic resonance (MR)-guided online-adaptive radiotherapy (SMART) may improve SBRT's therapeutic ratio. This prospective Phase I trial assessed feasibility and potential advantages of SMART to treat abdominal malignancies. MATERIALS/METHODS: Twenty patients with oligometastatic or unresectable primary liver (n = 10) and non-liver (n = 10) abdominal malignancies underwent SMART...
December 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29277249/fine-tuning-the-normal-tissue-objective-in-eclipse-for-lung-stereotactic-body-radiation-therapy
#13
James P Bell, Pretesh Patel, Kristin Higgins, Mark W McDonald, Justin Roper
The purpose of this study was to characterize the effects of the normal tissue objective (NTO) on lung stereotactic body radiation therapy (SBRT) dose distributions. The NTO is a spatially varying constraint used in Eclipse to limit dose to normal tissues by steepening the dose gradient. However, the multitude of potential NTO setting combinations challenges optimal NTO tuning. In the present study, a broad range of NTO settings are investigated for lung SBRT treatment planning with volumetric modulated arc therapy(VMAT)...
December 22, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29251083/effects-of-constraint-induced-movement-therapy-on-brain-glucose-metabolism-in-a-rat-model-of-cerebral-ischemia-a-micro-pet-ct-study
#14
Ying-Ying Li, Bei Zhang, Ke-Wei Yu, Ce Li, Hong-Yu Xie, Wei-Qi Bao, Yan-Yan Kong, Fang-Yang Jiao, Yi-Hui Guan, Yu-Long Bai
PURPOSE: Constraint-induced movement therapy (CIMT) can improve motor functions in stroke patients and ischemic rats. This study examined the effect of CIMT in ischemic rats using positron emission tomography (PET). METHODS: We used middle cerebral artery occlusion (MCAO) procedure to induce cerebral ischemia in rats. Male rats were divided into a negative control group (Normal, n = 4), a sham-operated group (Sham, n = 6), an ischemic group (Control, n = 6), and an ischemic CIMT-treated group (CIMT, n = 6)...
December 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29240293/transvenous-pacemaker-implantation-after-the-bidirectional-glenn-operation-for-patients-with-complex-congenital-disease
#15
Danielle E Harake, Kevin M Shannon, Jamil A Aboulhosn, Jeremy P Moore
INTRODUCTION: The bidirectional Glenn operation for congenital heart disease produces anatomical constraints to conventional transvenous pacemaker implantation. An iliac approach, although not previously described in this population, is potentially a preferable alternative to a thoracotomy for epicardial pacing. METHODS AND RESULTS: A single-center retrospective review was performed for all patients that underwent transvenous pacemaker implantation following the bidirectional Glenn operation with partial biventricular repair...
December 14, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29239731/practice-patterns-and-outcomes-for-pemetrexed-plus-platinum-doublet-as-neoadjuvant-chemotherapy-in-adenocarcinomas-of-lung-looking-beyond-the-usual-paradigm
#16
V Noronha, S Zanwar, A Joshi, V M Patil, A Mahajan, A Janu, J P Agarwal, P Bhargava, A Kapoor, K Prabhash
AIMS: Neoadjuvant chemotherapy (NACT) is the standard of care in non-small cell lung cancers (NSCLC) with locally advanced N2 disease. There is a scarcity of data for the pemetrexed-platinum regimen as NACT. Also, apart from N2 disease, the role of NACT in locally advanced NSCLCs for tumour downstaging is unclear. MATERIALS AND METHODS: Non-metastatic adenocarcinomas of lung treated with pemetrexed-platinum-based NACT were analysed. The patients with locoregionally advanced N2 disease and those who were borderline candidates for upfront definitive treatment were planned for NACT after discussion in a multidisciplinary clinic...
November 24, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29237970/a-dosimetric-comparison-between-three-dimensional-conformal-radiation-therapy-and-intensity-modulated-radiation-therapy-in-the-treatment-of-posterior-fossa-boost-in-medulloblastoma
#17
Meenu Gupta, Ravi Kant, Vipul Nautiyal, Jyoti Bisht, Shalindra Raghuvanshi, Manju Saini, B P Kalra, Mushtaq Ahmad
AIMS: To compare three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) in posterior fossa (PF) boost in children with medulloblastoma (MB); dosimetrically evaluating and comparing both techniques with regard to target coverage and doses to organs at risk. SETTINGS AND DESIGN: Structured. SUBJECTS AND METHODS: Seven previously irradiated patients of MB were retrieved and re-planned with both 3DCRT and IMRT techniques...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29237328/modeling-the-full-length-hiv-1-gag-polyprotein-reveals-the-role-of-its-p6-subunit-in-viral-maturation-and-the-effect-of-non-cleavage-site-mutations-in-protease-drug-resistance
#18
Chinh Tran-To Su, Chee-Keong Kwoh, Chandra Shekhar Verma, Samuel Ken-En Gan
HIV polyprotein Gag is increasingly found to contribute to protease inhibitor resistance. Despite its role in viral maturation and in developing drug resistance, there remain gaps in the knowledge of the role of certain Gag subunits (e.g. p6), and that of non-cleavage mutations in drug resistance. As p6 is flexible, it poses a problem for structural experiments, and is hence often omitted in experimental Gag structural studies. Nonetheless, as p6 is an indispensable component for viral assembly and maturation, we have modeled the full length Gag structure based on several experimentally determined constraints and studied its structural dynamics...
December 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29235903/brain-targeted-intranasal-zaleplon-solid-dispersion-in-hydrophilic-carrier-system-23-full-factorial-design-and-in-vivo-determination-of-gaba-neurotransmitter
#19
Eman Abd-Elrasheed, Sara Nageeb El-Helaly, Manal M El-Ashmoony, Salwa Salah
Intranasal Zaleplon solid dispersion was formulated to enhance the solubility, bioavailability and deliver an effective therapy. Zaleplon belongs to Class II drugs, and undergoes extensive first-pass metabolism after oral absorption exhibiting 30% bioavailability. A 23full factorial design was chosen for the investigation of solid dispersion formulations. The effects of different variables include drug to carrier ratio (1:1 and 1:2), carrier type (polyethylene glycol 4000 and poloxamer 407), and preparation method (solvent evaporation and freeze drying) on different dissolution parameters were studied...
December 13, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29228614/dual-effects-of-radiation-bystander-signaling-in-urothelial-cancer-purinergic-activation-of-apoptosis-attenuates-survival-of-urothelial-cancer-and-normal-urothelial-cells
#20
Malgorzata A Bill, Kirtiman Srivastava, Conor Breen, Karl T Butterworth, Stephen J McMahon, Kevin M Prise, Karen D McCloskey
Radiation therapy (RT) delivers tumour kill, directly and often via bystander mechanisms. Bladder toxicity is a dose limiting constraint in pelvic RT, manifested as radiation cystitis and urinary symptoms. We aimed to investigate the impact of radiation-induced bystander signaling on normal/cancer urothelial cells. Human urothelial cancer cells T24, HT1376 and normal urothelial cells HUC, SV-HUC were used. Cells were irradiated and studied directly, or conditioned medium from irradiated cells (CM) was transferred to naïve, cells...
November 14, 2017: Oncotarget
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