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mild traumatic brain injury treatment

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https://www.readbyqxmd.com/read/28701496/the-spectrum-of-mild-traumatic-brain-injury-a-review
#1
REVIEW
Andrew R Mayer, Davin K Quinn, Christina L Master
OBJECTIVE: This review provides an in-depth overview of diagnostic schema and risk factors influencing recovery during the acute, subacute (operationally defined as up to 3 months postinjury), and chronic injury phases across the full spectrum of individuals (e.g., athletes to neurosurgery patients) with mild traumatic brain injury (mTBI). Particular emphasis is placed on the complex differential diagnoses for patients with prolonged postconcussive symptoms. METHODS: Select literature review and synthesis...
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28686082/providing-dementia-consultations-to-veterans-using-clinical-video-telehealth-results-from-a-clinical-demonstration-project
#2
Stuti Dang, Carlos A Gomez-Orozco, Maria H van Zuilen, Silvina Levis
PURPOSE: Veterans with dementia and their caregivers in remote areas may not have access to specialists to provide diagnosis, treatment, and education. The purpose of this clinical demonstration project was to examine the feasibility, acceptability, and impact of a video consultations clinic for veterans with dementia or memory complaints and their caregivers. METHODS: The dementia clinical video telehealth (CVT) consultation clinic was established to identify, diagnose, and treat dementia in veterans at sites distant from the main medical center...
July 7, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28685977/the-post-therapeutic-effect-of-rapamycin-in-mild-traumatic-brain-injured-rats-ensuing-in-the-upregulation-of-autophagy-and-mitophagy
#3
Changxing Wang, Zhiying Hu, Yang Zou, Mingjun Xiang, Yuting Jiang, Benson O A Botchway, Xue Huo, Xiaoxue Du, Marong Fang
Mild traumatic brain injury (mTBI), common in juveniles, has been reported to be caused by sports-related concussion. Many young children may suffer from post-concussion syndrome. mTBI, in early stages of life, could play a part in neuron apoptosis and degeneration, cognitive and motor coordination impairment, as well as dementia. Our study was aimed at further investigating the post therapeutic efficacy of rapamycin in the recuperation of mTBI whiles at the same time investigating the metamorphosis in both autophagy and mitophagy in mTBI...
July 7, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28685618/minocycline-plus-n-acteylcysteine-induces-remyelination-synergistically-protects-oligodendrocytes-and-modifies-neuroinflammation-in-a-rat-model-of-mild-traumatic-brain-injury
#4
Margalit Haber, Jessica James, Justine Kim, Michael Sangobawole, Rachel Irizarry, Johnson Ho, Elena Nikulina, Natalia M Grin'kina, Albana Ramadani, Isabella Hartman, Peter J Bergold
Mild traumatic brain injury afflicts over 2 million people annually and little can be done for the underlying injury. The Food and Drug Administration-approved drugs Minocycline plus N-acetylcysteine (MINO plus NAC) synergistically improved cognition and memory in a rat mild controlled cortical impact (mCCI) model of traumatic brain injury.(3) The underlying cellular and molecular mechanisms of the drug combination are unknown. This study addressed the effect of the drug combination on white matter damage and neuroinflammation after mCCI...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28682314/nasal-application-of-hsv-encoding-human-preproenkephalin-blocks-craniofacial-pain-in-a-rat-model-of-traumatic-brain-injury
#5
A C Meidahl, M Klukinov, A Z Tzabazis, J C Sorensen, D C Yeomans
According to Centers for Disease Control and Prevention, each year, an estimated 1.7 million Americans sustain a traumatic brain injury (TBI), which frequently leads to chronic craniofacial pain. In this study we examine a gene therapy approach to the treatment of post-TBI craniofacial neuropathic pain using nasal application of a Herpes Simplex Virus-based vector expressing human proenkephalin (SHPE) to target the trigeminal ganglia. Mild TBI was induced in rats by use of a modified Fluid Percussion Model...
July 6, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28649193/repeated-low-intensity-blast-exposure-is-associated-with-damaged-endothelial-glycocalyx-and-downstream-behavioral-deficits
#6
Aaron A Hall, Mirian I Mendoza, Hanbing Zhou, Michael Shaughness, Eric Maudlin-Jeronimo, Richard M McCarron, Stephen T Ahlers
Current clinical research into mild traumatic brain injury (mTBI) has focused on white matter changes as identified by advanced MRI based imaging techniques. However, perivascular tau accumulation in the brains of individuals diagnosed with mTBI suggests that the vasculature plays a key role in the pathology. This study used a rat model to examine whether the endothelial glycocalyx, a layer of the vasculature responsible for sensing luminal shear forces, is damaged by exposure to repeated low intensity blast, and whether this layer is associated with observed behavioral deficits...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28647552/clinical-utility-of-the-patient-health-questionnaire-9-in-the-assessment-of-major-depression-after-broad-spectrum-traumatic-brain-injury
#7
Jacobus Donders, Adriene Pendery
OBJECTIVE: To determine the predictive validity of the Patient Health Questionnaire-9 (PHQ-9) when screening for symptoms of depression following traumatic brain injury. DESIGN: Retrospective analysis of data collected as part of routine clinical outpatient care over a period of 30 months. PARTICIPANTS: Persons with mild to severe traumatic brain injury who were referred for neuropsychological evaluation within 1-12 months (N = 137). INTERVENTIONS: Not applicable...
June 21, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28623327/exendin-4-attenuates-blast-traumatic-brain-injury-induced-cognitive-impairments-losses-of-synaptophysin-and-in-vitro-tbi-induced-hippocampal-cellular-degeneration
#8
Lital Rachmany, David Tweedie, Vardit Rubovitch, Yazhou Li, Harold W Holloway, Dong Seok Kim, Whitney A Ratliff, Jessica N Saykally, Bruce A Citron, Barry J Hoffer, Nigel H Greig, Chaim G Pick
Mild blast traumatic brain injury (B-TBI) induced lasting cognitive impairments in novel object recognition and less severe deficits in Y-maze behaviors. B-TBI significantly reduced the levels of synaptophysin (SYP) protein staining in cortical (CTX) and hippocampal (HIPP) tissues. Treatment with exendin-4 (Ex-4) delivered by subcutaneous micro-osmotic pumps 48 hours prior to or 2 hours immediately after B-TBI prevented the induction of both cognitive deficits and B-TBI induced changes in SYP staining. The effects of a series of biaxial stretch injuries (BSI) on a neuronal derived cell line, HT22 cells, were assessed in an in vitro model of TBI...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606462/growing-literature-but-limited-evidence-a-systematic-review-regarding-prebiotic-and-probiotic-interventions-for-those-with-traumatic-brain-injury-and-or-posttraumatic-stress-disorder
#9
Lisa A Brenner, Kelly A Stearns-Yoder, Adam S Hoffberg, Molly E Penzenik, Amy J Starosta, Theresa D Hernández, Daniel A Hadidi, Christopher A Lowry
Traumatic brain injury (TBI) is highly prevalent among a wide range of populations, including civilians, military personnel, and Veterans. TBI sequelae may be further exacerbated by symptoms associated with frequently occurring comorbid psychiatric conditions, including posttraumatic stress disorder (PTSD). This is particularly true among the population of military personnel from recent conflicts in Iraq and Afghanistan, with a history of mild TBI (mTBI) and PTSD. The need for efficacious treatments for TBI and comorbid PTSD is significant, and evidence-based interventions for these frequently co-occurring conditions are limited...
June 9, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28557049/left-dorsolateral-prefrontal-cortex-rtms-in-alleviating-mtbi-related-headaches-and-depressive-symptoms
#10
Albert Leung, Valerie Metzger-Smith, Yifan He, James Cordero, Brandon Ehlert, David Song, Lisa Lin, Golshan Shahrokh, Alice Tsai, Michael Vaninetti, Thomas Rutledge, Greg Polston, Robert Sheu, Roland Lee
OBJECTIVE: Persistent mild traumatic brain injury related headache (MTBI-HA) represents a neuropathic pain state. This study tested the hypothesis that repetitive transcranial magnetic stimulation (rTMS) at the left prefrontal cortex can alleviate MTBI-HA and associated neuropsychological dysfunctions. METHODS AND MATERIALS: Veterans with MTBI-HA were randomized to receive four sessions of either real (REAL group) or sham (SHAM group) high frequency rTMS delivered at 10 Hz, 80% of resting motor threshold and 2000 pulses per session at >24 and <72 hours apart...
May 30, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28540042/factors-affecting-the-concussion-knowledge-of-athletes-parents-coaches-and-medical-professionals
#11
Michael D Cusimano, Stanley Zhang, Jane Topolovec-Vranic, Michael G Hutchison, Rowan Jing
OBJECTIVES: To determine the predictors of knowledge and awareness of concussion symptoms and outcomes through a survey of athletes, parents of players and coaches in sports settings in Canada. METHODS: A cross-sectional survey of athletic communities in Canada was conducted. Respondents' concussion knowledge score consists of responses to questions about the symptoms, diagnosis, and treatment of a concussion and the timing of return-to-sport post-concussion. The percentage of correct responses was defined as the "identification rate...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28529492/depression-in-men-and-women-one-year-following-traumatic-brain-injury-tbi-a-tbi-model-systems-study
#12
Sarah Lavoie, Samantha Sechrist, Nhung Quach, Reza Ehsanian, Thao Duong, Ian H Gotlib, Linda Isaac
In the general population, females experience depression at significantly higher rates than males. Individuals with traumatic brain injury (TBI) are at substantially greater risk for depression compared to the overall population. Treatment of, and recovery from, TBI can be hindered by depression; comorbid TBI and depression can lead to adverse outcomes and negatively affect multiple aspects of individuals' lives. Gender differences in depression following TBI are not well understood, and relevant empirical findings have been mixed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28520672/sertraline-for-major-depression-during-the-year-following-traumatic-brain-injury-a-randomized-controlled-trial
#13
Jesse R Fann, Charles H Bombardier, Nancy Temkin, Peter Esselman, Catherine Warms, Jason Barber, Sureyya Dikmen
OBJECTIVE: Major depressive disorder (MDD) is common and associated with impaired functioning after traumatic brain injury (TBI). Few placebo-controlled antidepressant trials exist in this population. We evaluated the efficacy and tolerability of sertraline for MDD within 1 year of sustaining a TBI. SETTING: Level I trauma center. PARTICIPANTS: Adults with MDD within 1 year of hospitalization for complicated mild to severe TBI. DESIGN: Randomized, double-blind, placebo-controlled trial...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28512443/transcranial-direct-current-stimulation-for-post-concussion-syndrome-study-protocol-for-a-randomized-crossover-trial
#14
Robson Luis Oliveira de Amorim, André Russowsky Brunoni, Mirian Akiko Furutani de Oliveira, Ana Luiza Costa Zaninotto, Marcia Mitie Nagumo, Vinícius Monteiro de Paula Guirado, Iuri Santana Neville, Gláucia Rosana Guerra Benute, Mara Cristina Souza de Lucia, Wellingson Silva Paiva, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira
BACKGROUND: Mild traumatic brain injury (MTBI) represents 70-80% of all treated brain injuries. A considerable proportion of MTBI patients experience post-concussion symptoms for a prolonged period after MTBI, and these symptoms are diagnosed as persistent post-concussion syndrome (PPCS). PPCS is defined as a range of physical, cognitive, and emotional symptoms. However, memory and executive dysfunction seems to be one of the most debilitating symptoms. Recently, non-invasive brain stimulation has been studied as a potential treatment method for traumatic brain injury (TBI) patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28508357/biofluid-proteomics-and-biomarkers-in-traumatic-brain-injury
#15
Safa Azar, Anwarul Hasan, Richard Younes, Farah Najdi, Lama Baki, Hussein Ghazale, Firas H Kobeissy, Kazem Zibara, Stefania Mondello
Traumatic brain injury (TBI) is an injury to the brain caused by an external mechanical force, affecting millions of people worldwide. The disease course and prognosis are often unpredictable, and it can be challenging to determine an early diagnosis in case of mild injury as well as to accurately phenotype the injury. There is currently no cure for TBI-drugs having failed repeatedly in clinical trials-but an intense effort has been put to identify effective neuroprotective treatment. The detection of novel biomarkers, to understand more of the disease mechanism, facilitates early diagnosis, predicts disease progression, and develops molecularly targeted therapies that would be of high clinical interest...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28506081/epidemiological-characteristics-of-chinese-paediatric-traumatic-brain-injury-inpatients
#16
Yunming Li, Fuqin Chen, Junran Zhang, Gang Li, Xiaoguang Yang, Qiang Lu, Xun Xia, Xinyan Zhang, Jun Qiu, Junpeng Zhang, Jihong Zhou, Yongqin Kuang, Jianwen Gu
PRIMARY OBJECTIVE: To investigate the epidemiological characteristics of paediatric inpatients with traumatic brain injury (TBI) in China. RESEARCH DESIGN: The Chinese Trauma Database (CTD), a nationwide register system based on hospital admission data, contains diagnosis and treatment information for trauma inpatients in over 200 military-managed public-service hospitals in China. Using the ICD-9 coding, the data for children with TBI aged 0-17 years between 2001 and 2007 were retrieved...
May 16, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28495608/short-term-caloric-restriction-exerts-neuroprotective-effects-following-mild-traumatic-brain-injury-by-promoting-autophagy-and-inhibiting-astrocyte-activation
#17
Yuan Liu, Rong Wang, Zhiwei Zhao, Wen Dong, Xu Zhang, Xi Chen, Lina Ma
Cognitive deficits may occur after mild traumatic brain injury (mTBI), but effective treatment modalities are presently unavailable. Caloric restriction (CR) has beneficial effects on neurodegenerative diseases and brain injury. However, the underlying mechanisms have not yet been clearly defined. Therefore, the aim of the present study was to investigate the short-term effects of CR treatment on cognitive function in mice after mTBI. Forty-five 12-week-old C57/BL6 mice were subjected to closed-head mTBI using a weight drop device...
May 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28487868/severe-symptomatic-acute-hyponatremia-in-traumatic-brain-injury-responded-very-rapidly-to-a-single-15-mg-dose-of-oral-tolvaptan-a-mayo-clinic-health-system-hospital-experience-need-for-caution-with-tolvaptan-in-younger-patients-with-preserved-renal-function
#18
Macaulay Amechi Chukwukadibia Onuigbo, Nneoma Agbasi
Tolvaptan is now well established as a potent pharmaceutical agent for symptomatic hyponatremia from syndrome of inappropriate antidiuretic hormone secretion (SIADH), congestive heart failure and liver cirrhosis. Previous studies had recruited older (63-65 years) patients with mild renal impairment (serum creatinine, 1.3-1.4 mg/dl). A 2012 report in the Journal of Neurology, Neurosurgery & Psychiatry described tolvaptan as a "lifesaving drug". A major outcome concern in the treatment of chronic hyponatremia is potentially fatal pontine demyelination from over-rapid correction of serum sodium >0...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28483652/associations-between-traumatic-brain-injury-history-and-future-headache-severity-in-veterans-a-longitudinal-study
#19
Pradeep Suri, Kelly Stolzmann, Katherine M Iverson, Rhonda Williams, Mark Meterko, Kun Yan, Katelyn Gormley, Terri K Pogoda
OBJECTIVE: To determine whether traumatic brain injury (TBI) history is associated with worse headache severity outcomes. DESIGN: Prospective cohort study. SETTING: Department of Veterans Affairs (VA) outpatient clinics. PARTICIPANTS: 2566 Veterans who completed a mail follow-up survey an average of 3 years after a comprehensive TBI evaluation (CTBIE). MAIN OUTCOME MEASURES: The presence or absence of TBI, and TBI severity, were evaluated by a trained clinician and classified according to VA/Department of Defense clinical practice guidelines...
May 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28482747/three-year-trends-in-veterans-health-administration-utilization-and-costs-after-traumatic-brain-injury-screening-among-veterans-with-mild-traumatic-brain-injury
#20
Brent C Taylor, Emily Hagel Campbell, Sean Nugent, Douglas E Bidelspach, Shannon M Kehle-Forbes, Joel Scholten, Kevin T Stroupe, Nina A Sayer
Examination of trends in Veterans Health Administration (VHA) healthcare utilization and costs among veterans with mild traumatic brain injury (mTBI) is needed to inform policy, resource allocation, and treatment planning. The objective of this study was to assess the patterns of VHA healthcare utilization and costs in the 3 years following TBI screening among veterans with mTBI, compared with veterans without TBI. A retrospective cohort study of veterans who underwent TBI screening in fiscal year 2010 was conducted...
June 27, 2017: Journal of Neurotrauma
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