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mild traumatic brain injury treatment

Jia Shi, Yuye Wang, Tunan Chen, Degang Xu, Hengli Zhao, Linyu Chen, Chao Yan, Longhuang Tang, Yixin He, Hua Feng, Jianquan Yao
The imaging diagnosis and prognostication of different degrees of traumatic brain injury (TBI) is very important for early care and clinical treatment. Especially, the exact recognition of mild TBI is the bottleneck for current label-free imaging technologies in neurosurgery. Here, we report an automatic evaluation method for TBI recognition with terahertz (THz) continuous-wave (CW) transmission imaging based on machine learning (ML). We propose a new feature extraction method for biological THz images combined with the transmittance distribution features in spatial domain and statistical distribution features in normalized gray histogram...
March 5, 2018: Optics Express
Hailong Song, Landry M Konan, Jiankun Cui, Catherine E Johnson, Martin Langenderfer, DeAna Grant, Tina Ndam, Agnes Simonyi, Tommi White, Utkan Demirci, David R Mott, Doug Schwer, Graham K Hubler, Ibolja Cernak, Ralph G DePalma, Zezong Gu
Explosive blast-induced mild traumatic brain injury (mTBI), a "signature wound" of recent military conflicts, commonly affects service members. While past blast injury studies have provided insights into TBI with moderate- to high-intensity explosions, the impact of primary low-intensity blast (LIB)-mediated pathobiology on neurological deficits requires further investigation. Our prior considerations of blast physics predicted ultrastructural injuries at nanoscale levels. Here, we provide quantitative data using a primary LIB injury murine model exposed to open field detonation of 350 grams of high-energy explosive C4...
March 8, 2018: Behavioural Brain Research
Mary Alexis Iaccarino, Lisa Liang Philpotts, Ross Zafonte, Joseph Biederman
OBJECTIVE: Mild traumatic brain injury (mTBI) often presents with cognitive complaints including difficulty with attention and concentration. As these symptoms resemble those of ADHD, stimulants may be a potential treatment for mTBI. This review evaluates the literature on the use of stimulants for the treatment of mTBI. METHOD: A systematic evaluation of the literature using six databases: Ovidmedline, Pubmed, psychINFO, CINAH, Embase, and Cochrane. Broad search terms were used and studies were included that evaluate the use of stimulant and stimulant-like medications in the mTBI population...
March 1, 2018: Journal of Attention Disorders
Tracey A Brickell, Louis M French, Sara M Lippa, Rael T Lange
OBJECTIVES: To (a) characterize a sample of post-9/11 caregivers providing help to service members and veterans (SMV) following traumatic brain injury (TBI), (b) examine the level of support provided, and (c) determine caregiver health and well-being outcomes. SETTING: Military treatment facility. PARTICIPANTS: Caregivers (N = 278) of SMVs who sustained a mild, moderate, severe, or penetrating TBI (96.0% female; 86.0% spouse/partner; age: M = 38...
March 2018: Journal of Head Trauma Rehabilitation
Jeanette R Little, Holly H Pavliscsak, Mabel R Cooper, Lois A Goldstein, Stephanie J Fonda
Introduction: Research has shown that mobile phones can help with management of numerous health problems. As an adjunct to care management provided to injured service members rehabilitating in their communities, particularly those with mild traumatic brain injury (mTBI), post-traumatic stress (PTS), and/or behavioral health problems, the Army developed a mobile phone application called "mCare." This study examined whether service members who received mCare had higher well-being, were more satisfied with their care, and viewed mCare as a valuable part of their care management as compared with their counterparts who received standard care management alone, and whether those with mTBI, PTS, and/or behavioral health problems benefited differently from mCare...
March 1, 2018: Military Medicine
Joseph F Kulas, Robert A Rosenheck
Introduction: Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are common military service-related conditions diagnosed both singly and together in veterans returning from recent military conflicts overseas. The impact of these disorders in real-world Veterans Health Administration practice has not been studied extensively, and few studies have examined the association of these disorders both by themselves and together with sociodemographic characteristics, psychiatric and medical comorbidities, health service utilization, and psychotropic medication fills...
March 1, 2018: Military Medicine
Jennifer M Flaherty, Robert J Spencer, Lauren L Drag, Percival H Pangilinan, Linas A Bieliauskas
OBJECTIVES: This study examined how depression, anxiety, and sleep items from the Neurobehavioral Symptom Inventory (NSI) predict results from longer inventories. METHOD: This was a retrospective review from 484, predominantly male (96.1%) Veterans, mean age 29.7 years, who underwent brief neuropsychological screening during a comprehensive, multidisciplinary evaluation for mild traumatic brain injury (TBI). Participants completed the NSI, insomnia severity index (ISI), and hospital anxiety and depression scale (HADS)...
March 6, 2018: Journal of Clinical Psychology
Fiona J Rowe, Kerry Hanna, Jennifer R Evans, Carmel P Noonan, Marta Garcia-Finana, Caroline S Dodridge, Claire Howard, Kathryn A Jarvis, Sonia L MacDiarmid, Tallat Maan, Lorraine North, Helen Rodgers
BACKGROUND: Acquired brain injury can cause eye movement disorders which may include: strabismus, gaze deficits and nystagmus, causing visual symptoms of double, blurred or 'juddery' vision and reading difficulties. A wide range of interventions exist that have potential to alleviate or ameliorate these symptoms. There is a need to evaluate the effectiveness of these interventions and the timing of their implementation. OBJECTIVES: We aimed to assess the effectiveness of any intervention and determine the effect of timing of intervention in the treatment of strabismus, gaze deficits and nystagmus due to acquired brain injury...
March 5, 2018: Cochrane Database of Systematic Reviews
Laurie-Ann Corbin-Berrigan, Kristina Kowalski, Jocelyn Faubert, Brian Christie, Isabelle Gagnon
As mild traumatic brain injury (mTBI) affects hundreds of thousands of children and their families each year, investigation of potential mTBI assessments and treatments is an important research target. Three-dimensional multiple object tracking (3D-MOT), where an individual must allocate attention to moving objects within 3D space, is one potentially promising assessment and treatment tool. To date, no research has looked at 3D-MOT in a pediatric mTBI population. Thus, the aim of this study was to examine 3D-MOT learning in children and youth with and without mTBI...
February 23, 2018: Neuroreport
Himakarnika Alluri, Chinchusha Anasooya Shaji, Matthew L Davis, Binu Tharakan
Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. It is a silently growing epidemic with multifaceted pathogenesis, and current standards of treatments aim to target only the symptoms of the primary injury, while there is a tremendous need to explore interventions that can halt the progression of the secondary injuries. The use of a reliable animal model to study and understand the various aspects the pathobiology of TBI is extremely important in therapeutic drug development against TBI-associated complications...
2018: Methods in Molecular Biology
Megan L Callahan, Daniel Storzbach
The purpose of this study was to examine the unique contribution of posttraumatic stress disorder (PTSD) symptoms on sensory sensitivity following mild traumatic brain injury (mTBI) in an Operation Enduring Freedom and Operation Iraqi Freedom (OEF/OIF) Veteran sample. We hypothesized that the effect of PTSD on noise and light sensitivity following mTBI would be largely driven by PTSD-related hyperarousal symptoms. We compared the relationships between PTSD, noise sensitivity, and light sensitivity of 49 OEF/OIF Veterans with mTBI to that of 23 OEF/OIF Veterans without mTBI...
February 21, 2018: Applied Neuropsychology. Adult
Raquel Langdon, Sharief Taraman
After sustaining a concussion or mild traumatic brain injury, headaches are one of the most common complaints. The pathophysiologic changes that occur in the setting of injury likely contribute to or cause posttraumatic headaches. Posttraumatic headaches often present as migraine or tension-type headaches. Unlike pain from other types of injuries, headaches following mild traumatic brain injury are more likely to persist. Preexisting conditions such as migraine and mood disorders may influence posttraumatic headache and complicate management...
February 1, 2018: Pediatric Annals
Meeryo Choe, Karen M Barlow
PURPOSE OF REVIEW: This article summarizes the impact and complications of mild traumatic brain injury and concussion in children and outlines the recent evidence for its assessment and early management. Useful evidence-based management strategies are provided for children who have a typical recovery following concussion as well as for those who have persistent postconcussion syndrome. Cases are used to demonstrate the commonly encountered pathologies of headache, cognitive issues, and mood disturbances following injury...
February 2018: Continuum: Lifelong Learning in Neurology
José Manuel Ortega Zufiría, Noemí Lomillos Prieto, Bernardino Choque Cuba, Martin Tamarit Degenhardt, Pedro Poveda Núñez, María Remedios López Serrano, Azahara Belén López Raigada
Introduction: Mild traumatic brain injury (TBI) represents a major health concern, because a sizeable number of patients with mild TBI will develop potentially life-threatening complications. The target of this study was to describe a large series of adult patients suffering from mild TBI, treated at University Hospital of Getafe, between 2010 and 2015 (n = 2480). We examined the patients' epidemiological and baseline clinical profile, diagnosis, treatment and ultimate outcomes, to identify major prognostic factors that influence the final result...
2018: Surgical Neurology International
Linda W Xu, Silvia D Vaca, Juliet Nalwanga, Christine Muhumuza, Daniel Vail, Benjamin J Lerman, Joel Kiryabwire Surg, Hussein Ssenyonjo, John Mukasa, Michael Muhumuza, Michael M Haglund, Gerald Grant
BACKGROUND: In the past decade, neurosurgery in Uganda experienced increasing surgical volume and a new residency training program. While research has examined surgical capacity, minimal data exists on the patient population treated by neurosurgery and their eventual outcomes in sub-Saharan Africa. METHODS: Patients admitted to Mulago National Referral Hospital neurosurgical ward over two years (2014 and 2015) were documented in a prospective database. 1167 were discharged with documented phone numbers, thus eligible for follow-up...
February 7, 2018: World Neurosurgery
Susan Ropacki, Risa Nakase-Richardson, Leah Farrell-Carnahan, Greg J Lamberty, Xinyu Tang
OBJECTIVE: Present initial descriptive findings from the Veterans Affairs (VA) Polytrauma Rehabilitation Centers (PRC) Traumatic Brain Injury (TBI) Model Systems (MS) National Database. DESIGN: Prospective cohort study. SETTING: VA PRC TBIMS National Database. PARTICIPANTS: 712 service members and veterans with TBI who consented to participate between January 2010 and June 2015. INTERVENTIONS: Not applicable...
February 6, 2018: Archives of Physical Medicine and Rehabilitation
Zahari N Tchopev, Ping-Hong Yeh, Greg W Morgan, Eric Meyer, Johanna M Wolf, John M Ollinger, Gerard P Riedy, Lisa C Young
Sleep-related hypermotor epilepsy (SHE) (previously frontal lobe epilepsy) is a rare seizure disorder commonly misdiagnosed or unrecognized, causing negative patient sequelae. While usually reported in familial studies, it is more commonly acquired. Diagnosis is a challenge due to its low incidence in comparison with the more common sleep disorders or psychogenic etiologies in the differential diagnosis. Diagnosis is scaled on degree of certainty based on described or clinically documented semiology, with video EEG as a helpful, but not necessary, adjunct...
2018: Frontiers in Neurology
Gyu-Sik Choi, Sang Gyu Kwak, Han Do Lee, Min Cheol Chang
OBJECTIVE: Central pain can occur following traumatic brain injury, leading to poor functional recovery, limitation of activities of daily living, and decreased quality of life. The aim of this study was to determine whether high-frequency (10 Hz) repetitive transcranial magnetic stimulation, applied over the primary motor cortex of the affected hemisphere, can be used to manage chronic central pain after mild traumatic brain injury. DESIGN: Prospective randomized feasibility study...
January 31, 2018: Journal of Rehabilitation Medicine
Deborah L Snell, Rachelle Martin, A D Macleod, Lois J Surgenor, Richard J Siegert, E Jean C Hay-Smith, Tracy Melzer, Gary J Hooper, Tim Anderson
OBJECTIVES: Post-concussion-like symptoms (PCS) are common in patients without a history of brain injury, such as those with chronic pain (CP). This exploratory study examined neuro-cognitive and psychological functioning in patients with PCS following mild traumatic brain injury (mTBI) or CP, to assess unique and overlapping phenomenology. METHODS: In this case-control study, participants (n = 102) with chronic symptoms after mTBI (n = 45) were matched with mTBI recovered (n = 31) and CP groups (n = 26), on age, gender, ethnicity and education...
February 1, 2018: Brain Injury: [BI]
Georgina Perez-Garcia, Rita De Gasperi, Miguel A Gama Sosa, Gissel M Perez, Alena Otero-Pagan, Anna Tschiffely, Richard M McCarron, Stephen T Ahlers, Gregory A Elder, Sam Gandy
Battlefield blast exposure related to improvised explosive devices (IEDs) has become the most common cause of traumatic brain injury (TBI) in the recent conflicts in Iraq and Afghanistan. Mental health problems are common after TBI. A striking feature in the most recent veterans has been the frequency with which mild TBI (mTBI) and posttraumatic stress disorder (PTSD) have appeared together, in contrast to the classical situations in which the presence of mTBI has excluded the diagnosis of PTSD. However, treatment of PTSD-related symptoms that follow blast injury has become a significant problem...
January 2018: ENeuro
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