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mild traumatic brain injury treatment

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https://www.readbyqxmd.com/read/27923323/mild-hypothermia-promotes-pericontusion-neuronal-sprouting-via-suppressing-socs3-expression-after-moderate-traumatic-brain-injury
#1
Cheng-Cheng Zhao, Chuan-Fang Wang, Wei-Ping Li, Yong Lin, Qi-Lin Tang, Jun-Feng Feng, Qing Mao, Guo-Yi Gao, Jiyao Jiang
Mild therapeutic hypothermia is a candidate for the treatment of traumatic brain injury (TBI). However, the role of mild hypothermia in neuronal sprouting after TBI remains obscure. We used a fluid percussion injury (FPI) model to assess the effect of mild hypothermia on pericontusion neuronal sprouting after TBI in rats. Male Sprague Dawley rats underwent FPI or sham surgery, and then followed by mild hypothermia treatment (33°C) or normothermia treatment (37°C) for 3 hours. All the rats were sacrificed at 7 days after FPI...
December 6, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27919376/usability-evaluation-of-the-smart-application-for-youth-with-mtbi
#2
Judith W Dexheimer, Brad G Kurowski, Shilo H Anders, Nicole McClanahan, Shari L Wade, Lynn Babcock
OBJECTIVE: There is a dearth of evidence-based treatments available to address the significant morbidity associated with mild traumatic brain injury (mTBI). To address this gap, we designed a novel user-friendly, web-based application. We describe the preliminary evaluation of feasibility and usability of the application to promote recovery following mTBI in youth, the Self-Monitoring Activity-Restriction and Relaxation Treatment (SMART). SMART incorporates real-time recommendations for individualized symptom management and activity restriction along with training in cognitive-behavioral coping strategies...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27911071/severe-brain-injury-in-massachusetts-assessing-the-continuum-of-care
#3
Laura Lorenz, Gabrielle Katz
Acquired brain injury (ABI) is a major public health problem in Massachusetts (Hackman et al, 2014) and includes traumatic brain injury (TBI), stroke, ABI-related infectious diseases, metabolic disorders affecting the central nervous system (brain and spinal cord), and brain tumor. Advances in emergency medical care and neurosurgery mean that more people are surviving severe traumatic brain injury (Trexler et al, 2014). Yet many patients with severe TBI in particular, are not receiving inpatient services after initial treatment (Hackman et al, 2014; CDC, 2014) or later that are known to be effective (Malec & Kean, 2015; Lewis & Horn, 2015; BI Commission, 2011; Kolakowsky-Hayner et al, 2000; Interviews)...
December 10, 2015: Issue Brief
https://www.readbyqxmd.com/read/27903419/short-term-efficacy-and-tolerability-of-methylphenidate-in-children-with-traumatic-brain-injury-and-attention-problems
#4
Ozalp Ekinci, Meltem Çobanoğulları Direk, Serkan Gunes, Halenur Teke, Nuran Ekinci, Fatma Yıldırım, Çetin Okuyaz
PURPOSE: This study aims to investigate the short-term efficacy and tolerability of immediate-release methylphenidate (IR-MPH) in children with a history of traumatic brain injury (TBI). METHODS: Twenty children with TBI (mean age: 12.7±3.1years) who had clinically significant attention deficit and/or hyperactivity-impulsivity symptoms and twenty children with primary Attention Deficit Hyperactivity Disorder (ADHD) (mean age: 12.3±3.05years) were included. Study measures, which included the Turgay DSM-IV based ADHD rating Scale (T-DSM-IV-S), Conners' Parent Rating Scale (CPRS), Conners' Teacher Rating Scale (CTRS-R) and Clinical Global Impression-Improvement Scale (CGI-I), were completed at the baseline for both of the groups...
November 28, 2016: Brain & Development
https://www.readbyqxmd.com/read/27899434/development-of-cgrp-dependent-pain-and-headache-related-behaviours-in-a-rat-model-of-concussion-implications-for-mechanisms-of-post-traumatic-headache
#5
Dara Bree, Dan Levy
BACKGROUND AND OBJECTIVE: Posttraumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a mild traumatic brain injury, or concussion. However, the mechanisms underlying PTH remain elusive, in part due to the lack of a clinically relevant animal model. Here, we characterized for the first time, headache and pain-related behaviours in a rat model of concussion evoked by a mild closed head injury (mCHI) - the major type of military and civilian related trauma associated with PTH - and tested responses to current and novel headache therapies...
November 29, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27898153/postconcussive-symptom-overreporting-in-iraq-afghanistan-veterans-with-mild-traumatic-brain-injury
#6
Sarah M Jurick, Elizabeth W Twamley, Laura D Crocker, Chelsea C Hays, Henry J Orff, Shahrokh Golshan, Amy J Jak
A comprehensive evaluation, including the assessment of neurobehavioral symptoms, has been instituted at the Department of Veterans Affairs (VA) healthcare system to address the large number of Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Veterans returning with mild traumatic brain injuries (mTBIs). The Validity-10 is measure of symptom overreporting embedded within the Neurobehavioral Symptom Inventory, a component of the comprehensive evaluation that assesses postconcussive symptom severity...
2016: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/27889957/acute-or-delayed-treatment-with-anatabine-improves-spatial-memory-and-reduces-pathological-sequelae-at-chronic-timepoints-after-repetitive-mild-tbi
#7
Scott Ferguson, Benoit Christian Mouzon, Daniel Paris, Destinee Aponte, Laila Abdullah, William Stewart, Michael Mullan, Fiona C Crawford
Traumatic brain injury (TBI) has chronic and long term consequences for which there are currently no approved pharmacological treatments. We have previously characterized the chronic neurobehavioral and pathological sequelae of a mouse model of repetitive mild TBI (r-mTBI) to two years post-TBI. Despite the mild nature of the initial insult, secondary injury processes are initiated which involve neuroinflammatory and neurodegenerative pathways persisting and progressing for weeks and months post-injury and providing a potential window of opportunity for therapeutic intervention...
November 27, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27889010/neuropsychiatric-aspects-of-concussion
#8
REVIEW
Rajiv Radhakrishnan, Amir Garakani, Lawrence S Gross, Marcia K Goin, Janet Pine, Andrew E Slaby, Calvin R Sumner, David A Baron
Over the past decade, concussion has become the most widely discussed injury in contact sports. However, concussions also occur in several other settings, such as non-contact sports, elderly individuals, young children, military personnel, and victims of domestic violence. Concussion is frequently undiagnosed as a cause of psychiatric morbidity, especially when the patient has no history of loss of consciousness or direct head trauma. Almost all of the extant literature focuses on traumatic brain injury and assumes that concussion is merely a mild form of traumatic brain injury, which has resulted in a lack of understanding about what concussion is, and how to diagnose, monitor, and treat its varied neuropsychiatric symptoms...
December 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27861473/-direct-cost-of-primary-care-of-mild-traumatic-brain-injury-in-adults-by-grd-in-third-level-of-care
#9
Rodolfo Barragán-Hervella, Álvaro Montiel-Jarquín, Iván Limón-Serrano, Víctor Escobedo-Sosa, Jorge Loría-Castellanos
OBJECTIVE: To describe the direct cost of primary health care for patients with mild traumatic head injury in a third level medical facility. DESIGN: Cross-sectional study in 219 patients with mild traumatic brain injury (GRD 090 S06.0 ICD-10 including uncomplicated concussion without complication and increased comorbidity). LOCATION: A medical unit of tertiary care in the State of Puebla, Mexico. MAIN MEASUREMENTS: Direct costs were taken from ACDO...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27858189/ambulatory-or-inpatient-management-of-mild-tbi-in-children-a-post-concussion-analysis
#10
Danielle S Wendling-Keim, Adriana König, Hans-Georg Dietz, Markus Lehner
BACKGROUND: Diagnosis and treatment of children with mild traumatic brain injury (mTBI) remain a challenge since initial signs and symptoms do not always indicate the severity of the trauma. Therefore, guidelines regarding the decision upon imaging methods and ambulatory or hospitalized treatment are needed. The goal of our study was to investigate if the standard that was allied from the PECARN rules and is applied in this study can ensure that patients with clinically important brain injury are recognized and leads to outcomes with a low complication rate, a high patient satisfaction and minimal post-concussion syndrome incidence...
November 17, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27855264/acute-effects-of-near-infrared-light-therapy-on-brain-state-in-healthy-subjects-as-quantified-by-qeeg-measures
#11
Fred Grover, Jon Weston, Michael Weston
OBJECTIVE: Recent investigation suggests that near infrared (NIR) light may improve symptoms from mild traumatic brain injury. In addition, quantitative electroencephalography (qEEG) has shown measures correlating with concussion: P300, reaction time, and amplitude. The objective of this study was to determine whether NIR light treatment has an acute effect on brain state in healthy patients as measured by EEG. METHODS: A total of 31 healthy volunteers, between the ages of 14 and 65, underwent qEEG event-related response tests before and after a 20-min NIR light head treatment...
November 17, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27845037/novel-glp-1r-gipr-co-agonist-twincretin-is-neuroprotective-in-cell-and-rodent-models-of-mild-traumatic-brain-injury
#12
Ian A Tamargo, Miaad Bader, Yazhou Li, Seong-Jin Yu, Yun Wang, Konrad Talbot, Richard D DiMarchi, Chaim G Pick, Nigel H Greig
Several single incretin receptor agonists that are approved for the treatment of type 2 diabetes mellitus (T2DM) have been shown to be neuroprotective in cell and animal models of neurodegeneration. Recently, a synthetic dual incretin receptor agonist, nicknamed "twincretin," was shown to improve upon the metabolic benefits of single receptor agonists in mouse and monkey models of T2DM. In the current study, the neuroprotective effects of twincretin are probed in cell and mouse models of mild traumatic brain injury (mTBI), a prevalent cause of neurodegeneration in toddlers, teenagers and the elderly...
November 11, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27836507/use-of-a-multi-level-mixed-methods-approach-to-study-the-effectiveness-of-a-primary-care-progressive-return-to-activity-protocol-after-acute-mild-traumatic-brain-injury-concussion-in-the-military
#13
Emma Gregory, Therese A West, Wesley R Cole, Jason M Bailie, Karen L McCulloch, Mark L Ettenhofer, Amy Cecchini, Felicia M Qashu
The large number of U.S. service members diagnosed with concussion/mild traumatic brain injury each year underscores the necessity for clear and effective clinical guidance for managing concussion. Relevant research continues to emerge supporting a gradual return to pre-injury activity levels without aggravating symptoms; however, available guidance does not provide detailed standards for this return to activity process. To fill this gap, the Defense and Veterans Brain Injury Center released a recommendation for primary care providers detailing a step-wise return to unrestricted activity during the acute phase of concussion...
November 9, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27813685/physical-activity-and-intermittent-postconcussion-symptoms-after-a-period-of-symptom-limited-physical-and-cognitive-rest
#14
Quinton Sawyer, Brian Vesci, Tamara C Valovich McLeod
: Reference: Schneider KJ, Iverson GL, Emery CA, McCrory P, Herring SA, Meeuwisse WH. The effects of rest and treatment following sport-related concussion: a systematic review of the literature. Br J Sports Med. 2013;47(5):304-307. CLINICAL QUESTION: After concussion and a period of symptom-limited physical and cognitive rest, do athletes who experience intermittent symptoms return to asymptomatic condition more quickly with physical activity than with prolonged physical rest? DATA SOURCES: One investigator performed an individual search for each research question using the following databases: CINAHL, Cochrane Controlled Trials Registers, EMBASE, HealthSTAR, ProQuest, PsychInfo, PubMed, SPORTDiscus, and Web of Science...
September 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27800660/treatment-of-severe-adult-traumatic-brain-injury-using-bone-marrow-mononuclear-cells
#15
Charles S Cox, Robert A Hetz, George P Liao, Benjamin M Aertker, Linda Ewing-Cobbs, Jenifer Juranek, Sean I Savitz, Margaret L Jackson, Anna M Romanowska-Pawliczek, Fabio Triolo, Pramod K Dash, Claudia Pedroza, Dean A Lee, Laura Worth, Imoigele P Aisiku, Huimahn A Choi, John B Holcomb, Ryan S Kitagawa
BACKGROUND: Numerous pre-clinical studies using bone marrow derived cells for the treatment of traumatic brain injury and stroke have demonstrated efficacy in terms of blood-brain barrier preservation, neurogenesis, and other functional outcomes. Phase 1 clinical trials using bone marrow mononuclear cells infused intravenously in children with severe TBI demonstrated safety and potentially a CNS structural preservation treatment effect. This study sought to confirm the safety, logistic feasibility, and potential treatment effect size of structural preservation/inflammatory biomarker mitigation in adults to guide Phase 2 clinical trial design...
November 1, 2016: Stem Cells
https://www.readbyqxmd.com/read/27793733/post-blast-treatment-with-nociceptin-orphanin-fq-peptide-nop-receptor-antagonist-reduces-brain-injury-induced-hypoxia-and-signaling-proteins-in-vestibulomotor-related-brain-regions
#16
Hibah O Awwad, Cindy D Durand, Larry P Gonzalez, Paul Tompkins, Yong Zhang, Megan R Lerner, Daniel J Brackett, David M Sherry, Vibhudutta Awasthi, Kelly M Standifer
Mild traumatic brain injury (mTBI) diagnoses have increased due to aggressive sports and blast-related injuries, but the cellular mechanisms and pathology underlying mTBI are not completely understood. Previous reports indicate that Nociceptin Orphanin/FQ (N/OFQ), an endogenous neuropeptide, contributes to post-injury ischemia following mechanical brain injury, yet its specific role in cerebral hypoxia, vestibulomotor function and injury marker expression following blast-induced TBI is not known. This study is the first to identify a direct association of N/OFQ and its N/OFQ peptide (NOP) receptor with TBI-induced changes following a single 80psi head blast exposure in male rats...
October 25, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27768069/a-repetitive-concussive-head-injury-model-in-mice
#17
Zhihui Yang, Fan Lin, Amanda S Weissman, Emily Jaalouk, Qing-Shan Xue, Kevin K W Wang
Despite the concussion/ mild traumatic brain injury (mTBI) being the most frequent occurrence of traumatic brain injury, there is still a lack of knowledge on the injury and its effects. To develop a better understanding of concussions, animals are often used because they provide a controlled, rigorous, and efficient model. Studies have adapted traditional animal models to perform mTBI to stimulate mild injury severity by changing the injury parameters. These models have been used because they can produce morphologically similar brain injuries to the clinical condition and provide a spectrum of injury severities...
October 12, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27766068/mild-traumatic-brain-injury-produces-neuron-loss-that-can-be-rescued-by-modulating-microglial-activation-using-a-cb2-receptor-inverse-agonist
#18
Wei Bu, Huiling Ren, Yunping Deng, Nobel Del Mar, Natalie M Guley, Bob M Moore, Marcia G Honig, Anton Reiner
We have previously reported that mild TBI created by focal left-side cranial blast in mice produces widespread axonal injury, microglial activation, and a variety of functional deficits. We have also shown that these functional deficits are reduced by targeting microglia through their cannabinoid type-2 (CB2) receptors using 2-week daily administration of the CB2 inverse agonist SMM-189. CB2 inverse agonists stabilize the G-protein coupled CB2 receptor in an inactive conformation, leading to increased phosphorylation and nuclear translocation of the cAMP response element binding protein (CREB), and thus bias activated microglia from a pro-inflammatory M1 to a pro-healing M2 state...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27743528/mild-traumatic-brain-injury-and-suicide-risk-among-a-clinical-sample-of-deployed-military-personnel-evidence-for-a-serial-mediation-model-of-anger-and-depression
#19
Ian H Stanley, Thomas E Joiner, Craig J Bryan
Research has demonstrated a robust link between traumatic brain injuries (TBIs) and suicide risk. Yet, few studies have investigated factors that account for this link. Utilizing a clinical sample of deployed military personnel, this study aimed to examine a serial meditation model of anger and depression in the association of mild TBI and suicide risk. A total of 149 military service members referred for evaluation/treatment of a suspected head injury at a military hospital participated in the present study (92...
October 7, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27741219/statements-of-agreement-from-the-targeted-evaluation-and-active-management-team-approaches-to-treating-concussion-meeting-held-in-pittsburgh-october-15-16-2015
#20
Michael W Collins, Anthony P Kontos, David O Okonkwo, Jon Almquist, Julian Bailes, Mark Barisa, Jeffrey Bazarian, O Josh Bloom, David L Brody, Robert Cantu, Javier Cardenas, Jay Clugston, Randall Cohen, Ruben Echemendia, R J Elbin, Richard Ellenbogen, Janna Fonseca, Gerard Gioia, Kevin Guskiewicz, Robert Heyer, Gillian Hotz, Grant L Iverson, Barry Jordan, Geoffrey Manley, Joseph Maroon, Thomas McAllister, Michael McCrea, Anne Mucha, Elizabeth Pieroth, Kenneth Podell, Matthew Pombo, Teena Shetty, Allen Sills, Gary Solomon, Danny G Thomas, Tamara C Valovich McLeod, Tony Yates, Ross Zafonte
BACKGROUND: Conventional management for concussion involves prescribed rest and progressive return to activity. Recent evidence challenges this notion and suggests that active approaches may be effective for some patients. Previous concussion consensus statements provide limited guidance regarding active treatment. OBJECTIVE: To describe the current landscape of treatment for concussion and to provide summary agreements related to treatment to assist clinicians in the treatment of concussion...
December 2016: Neurosurgery
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