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https://www.readbyqxmd.com/read/28342973/effects-of-a-sustained-release-formulation-of-1-25-dihydroxyvitamin-d3-glycosides-for-milk-fever-prevention-on-serum-1-25-dihydroxyvitamin-d3-calcium-and-phosphorus-in-dairy-cows
#1
Heinrich Bachmann, Michael Lanz, Susanne Kehrle, Wolfgang Bittner, Annick Toggenburger, Georg A Mathis, Walter Rambeck
Milk fever (MF) is a metabolic disease in dairy cows around parturition. The clinical lead sign is muscular paresis leading in severe cases to paralysis of the affected animal. Multiparturient animals of high performing dairy breeds are most likely to be affected and have a high probability of recurrence. An acute drop in blood calcium levels causes the disease when the demand for calcium at the onset of lactation exceeds the ability to replete blood calcium levels through mobilization from bone and intestinal uptake...
March 22, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28342789/enhanced-gastric-stability-of-esomeprazole-by-molecular-interaction-and-modulation-of-microenvironmental-ph-with-alkalizers-in-solid-dispersion
#2
Hien Van Nguyen, Namhyun Baek, Beom-Jin Lee
Due to the instability of esomeprazole magnesium dihydrate (EPM), a proton pump inhibitor, in gastric fluid, enteric-coated dosage form is commonly used for therapeutic application. In this study, we prepared new gastric fluid resistant solid dispersions (SDs) containing alkalizers. Then, new mechanistic evidence regarding the effects of pharmaceutical alkalizers on the aqueous stability of EPM in simulated gastric fluid was investigated. The alkalizer-loaded SD were prepared by dissolving or dispersing EPM, hydroxypropyl methylcellulose (HPMC) 6 cps, and an alkalizer, in ethanol 50% (v/v) followed by spray drying...
March 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28342344/water-hardness-determines-226-ra-uptake-in-the-tropical-freshwater-mussel
#3
Che Doering, Andreas Bollhöfer
Chemical data for freshwater mussels (Velesunio spp.) and water from 15 sampling sites in the Alligator Rivers Region and Rum Jungle uranium provinces in tropical Northern Australia were analysed to develop a predictive model of radium-226 ((226)Ra) bioaccumulation for variable water calcium (Ca) and magnesium (Mg) concentrations. Application of the model as a (226)Ra screening approach for freshwater mussels in tropical waterbodies potentially impacted by operational or remediated uranium mine sites is discussed in relation to Mudginberri Billabong, located approximately 12 km downstream of Ranger uranium mine in the Alligator Rivers Region...
March 22, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28339274/exact-model-of-vacancy-mediated-solute-transport-in-magnesium
#4
Ravi Agarwal, Dallas R Trinkle
Most substitutional solutes in solids diffuse via vacancies. However, widely used analytic models for diffusivity make uncontrolled approximations in the relations between atomic jump rates that reduce accuracy. Symmetry analysis of the hexagonal close packed crystal identifies more distinct vacancy transitions than prior models, and a Green function approach computes diffusivity exactly for solutes in magnesium. We find large differences for the solute drag of Al, Zn, and rare earth solutes, and improved diffusion activation energies-highlighting the need for exact analytic transport models...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28338895/photosynthesis-nutrient-accumulation-and-growth-of-two-betula-species-exposed-to-waterlogging-in-late-dormancy-and-in-the-early-growing-season
#5
Ai-Fang Wang, Marja Roitto, Tarja Lehto, Sirkka Sutinen, Jaakko Heinonen, Gang Zhang, Tapani Repo, Ram Oren
Increased risk of soil waterlogging in winter and spring at northern latitudes will potentially affect forest production in the future. We studied gas exchange, chlorophyll content index, chlorophyll fluorescence, nutrient concentration and biomass accumulation in 1-year-old silver (Betula pendula Roth) and pubescent birch (Betula pubescens Ehrh.) seedlings. We hypothesized that B. pubescens has different physiological mechanisms that make it tolerate waterlogging better than B. pendula. The treatments were: (i) no waterlogging throughout the experiment; (ii) 4-week waterlogging during dormancy (dormancy waterlogging 'DW'); (iii) 4-week waterlogging during the early growing season (growth waterlogging 'GW'); and (iv) 4-week DW followed by 4-week GW during the early growing season ('DWGW')...
March 15, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338765/cerebral-magnesium-levels-in-preeclampsia-a-phosphorus-magnetic-resonance-spectroscopy-study
#6
Maria Nelander, Jan Weis, Lina Bergman, Anders Larsson, Anna-Karin Wikström, Johan Wikström
BACKGROUND: Magnesium sulfate (MgSO4) is used as a prophylaxis for eclamptic seizures. The exact mechanism of action is not fully established. We used phosphorus magnetic resonance spectroscopy (31P-MRS) to investigate if cerebral magnesium (Mg2+) levels differ between women with preeclampsia, normal pregnant, and nonpregnant women. METHODS: This cross-sectional study comprised 28 women with preeclampsia, 30 women with normal pregnancies in corresponding gestational week (range: 23-41 weeks) and 11 nonpregnant healthy controls...
February 21, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28338462/perioperative-calcium-magnesium-and-phosphorus-in-living-liver-donors
#7
Raymond A Dieter
No abstract text is available yet for this article.
April 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28337451/in-vitro-studies-on-the-degradability-bioactivity-and-cell-differentiation-of-prp-az31b-mg-alloys-composite-scaffold
#8
Jian Zou, Zhongmin Shi, Hongwei Xu, Xiaolin Li
In recent years, more and more methods have been developed to improve the bioactivity of the biodegradable materials in bone tissue regeneration. In present study, we used rat mesenchymal stem cells (rMSCs) to evaluate the outcomes of Mg alloys (AZ31B, Magnesium, and Aluminum) and Platelet-rich plasma (PRP)/Mg alloys on rMSCs biocompatibility and osteogenic differentiation. Water absorption experiments indicated that both bare AZ31B and PRP/AZ31B were capable of absorbing large amounts of water. But the water absorption ratio for PRP/AZ31B was significantly higher than that for bare AZ31B...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28336824/-the-functions-of-calcium-sensing-receptor-in-regulating-mineral-metabolism
#9
Yuka Kinoshita
Calcium-sensing receptor(CaSR)which belongs to a G protein-coupled receptor family is one of the key elements in regulating calcium homeostasis. CaSR has been identified as a receptor to control parathyroid hormone(PTH)secretion in parathyroid glands according to serum calcium ion(Ca2+)levels. It has also been shown that CaSR controls reabsorption of water and several cations including Ca2+and magnesium ion(Mg2+)in renal tubular cells. This review summarizes the functions and roles of CaSR in mineral metabolism that are exerted in parathyroid glands, kidney, and intestine...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28336092/physiological-and-biochemical-responses-of-salix-integra-thunb-under-copper-stress-as-affected-by-soil-flooding
#10
Yini Cao, Chuanxin Ma, Guangcai Chen, Jianfeng Zhang, Baoshan Xing
To explore the joint effect of copper (Cu) and flooding on Salix integra Thunb. (S. integra), the physiological and biochemical parameters of the seedlings grown in Cu amended soil (50, 150, 450 mg kg(-1)) with or without the flooding for 60 days were evaluated. The results suggested that the flooding significantly inhibited the root growth in terms of root length and root tips. The Cu exposures of 50 and 150 mg kg(-1) notably enhanced the root growth as compared to the control. Majority of Cu was accumulated in S...
March 21, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28334028/providencia-stuartii-form-biofilms-and-floating-communities-of-cells-that-display-high-resistance-to-environmental-insults
#11
Mariam El Khatib, Que-Tien Tran, Chady Nasrallah, Julie Lopes, Jean-Michel Bolla, Michel Vivaudou, Jean-Marie Pagès, Jacques-Philippe Colletier
Biofilms are organized communities of bacterial cells that are responsible for the majority of human chronic bacterial infections. Providencia stuartii is a Gram-negative biofilm-forming bacterium involved in high incidence of urinary tract infections in catheterized patients. Yet, the structuration of these biofilms, and their resistance to environmental insults remain poorly understood. Here, we report on planktonic cell growth and biofilm formation by P. stuartii, in conditions that mimic its most common pathophysiological habitat in humans, i...
2017: PloS One
https://www.readbyqxmd.com/read/28333865/clinical-application-of-perioperative-multimodal-analgesia
#12
Jörgen Bruhn, Gert J Scheffer, Geert-Jan van Geffen
PURPOSE OF REVIEW: The experience of intense postoperative pain remains a significant problem in perioperative medicine. The mainstay of postoperative analgetic therapy is the combination of nonopioid agents (e.g. paracetamol and NSAIDs) with strong opioids (e.g. morphine) according to the WHO analgesic ladder. But as the incidence and intensity of postoperative pain remains high, the search for and evaluation of additional concepts is ongoing. This review highlights the current trends of perioperative multimodal analgesia concepts...
March 22, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28333317/characterization-of-a-gene-encoding-a-membrane-protein-that-affects-exopolysaccharide-production-and-intracellular-mg2-concentrations-in-ensifer-meliloti
#13
Justin P Hawkins, Ivan J Oresnik
Exopolysaccharides play an important role in the physiology of a bacterial cell. Ensifer meliloti is capable of producing at least two types of exopolysaccharides (EPS); succinoglycan, and galactoglucan. In E. meliloti exopolysaccharides are best known for their role in mediating interaction with its symbiotic hosts. It was previously shown that high concentrations of Mg 2+ or K + were capable of suppressing the mucoid phenotype associated with galactoglucan production in an expR+ derivative of Rm1021. In an attempt to determine how Mg 2+ regulates galactoglucan production, SRmD363 was mutagenized and screened for mutants which were visibly mucoid at high concentrations of magnesium...
March 16, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28332859/magnesium-sulfate-mediate-morphine-administration-reduction-in-varicocelectomy-surgery
#14
Sedigheh Nadri, Hormoz Mahmoudvand, Mahmoud Reza Moradkhani
AIMS: Varicocelectomy is the most common operation carried out by doctors for male infertility treatment. The aim of varicocele treatment is to hinder the refluxing venous drainage to the testis, retaining arterial inflow, and lymphatic drainage. A lot of pain is generated after this surgery, and the use of opium should be reduced to nearest minimum, as all drugs are toxins. Thus the aim of the present study is to facilitate morphine usage reduction after varicocelectomy surgery. MATERIAL AND METHODS: One-hundred (100) patients who were varicocelectomy candidate were randomized into two groups: experimental group contain 50 patients and control group contain 50 patients as well...
March 23, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28332537/mapping-vibrational-surface-and-bulk-modes-in-a-single-nanocube
#15
Maureen J Lagos, Andreas Trügler, Ulrich Hohenester, Philip E Batson
Imaging of vibrational excitations in and near nanostructures is essential for developing low-loss infrared nanophotonics, controlling heat transport in thermal nanodevices, inventing new thermoelectric materials and understanding nanoscale energy transport. Spatially resolved electron energy loss spectroscopy has previously been used to image plasmonic behaviour in nanostructures in an electron microscope, but hitherto it has not been possible to map vibrational modes directly in a single nanostructure, limiting our understanding of phonon coupling with photons and plasmons...
March 22, 2017: Nature
https://www.readbyqxmd.com/read/28331937/whey-protein-and-albumin-effects-upon-urinary-risk-factors-for-stone-formation
#16
Camila Mithie Hattori, Hans-Göran Tiselius, Ita Pfeferman Heilberg
Protein supplements are consumed for an expected increase in muscle mass and improved exercise performance, but as their impact on lithogenic parameters are unknown, we aimed to evaluate the effects of Whey protein (WP) and Albumin upon the risk factors for nephrolithiasis. WP or Albumin supplements (one scoop/day) were administered for 3 days to 18 healthy volunteers, with 1-week washout period between them. Serum and 24-h urine samples were collected at baseline and after completing each intervention. All participants were asked to replicate their baseline diet during the subsequent urine collection...
March 22, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28330893/analysis-of-mic-and-disk-diffusion-testing-variables-for-gepotidacin-and-comparator-agents-against-select-bacterial-pathogens
#17
L K Koeth, J M DiFranco-Fisher, N E Scangarella-Oman, L A Miller
This study was conducted to determine the effect of testing parameters on the in vitro activity of gepotidacin, a new triazaacenaphthylene antibacterial agent for the treatment of conventional and biothreat pathogens. CLSI methods, and variations of these methods were used to test 10 Staphylococcus aureus, 10 Streptococcus pneumoniae, 10 Haemophilus influenzae, and 5 Escherichia coli by MIC and 30 S. aureus, 15 S. pneumoniae and 15 S. pyogenes by disk diffusion (DD) methods. Levofloxacin and linezolid were tested as comparator agents for MIC and DD methods, respectively...
March 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28330645/design-of-fixed-dose-combination-and-physicochemical-characterization-of-enteric-coated-bilayer-tablet-with-circadian-rhythmic-variations-containing-telmisartan-and-pravastatin-sodium
#18
Daoqi Luo, Joo Hee Kim, Chulhun Park, Euichaul Oh, Jun Bum Park, Jing-Hao Cui, Qing-Ri Cao, Beom-Jin Lee
The aim of this study was to investigate a fixed dose combination (FDC) of telmisartan (TEL) and pravastatin sodium (PRA) in enteric-coated bilayer tablets, which was designed for once-daily bedtime dose in order to match circadian rhythmic variations of hypertension and cholesterol synthesis and optimize the patient friendly dosing treatment. Due to the poor aqueous solubility of TEL, a ternary solid dispersions (SD) consisting of TEL, polyethylene glycol 6000 (PEG 6000) and magnesium oxide (MgO) were designed to enhance its dissolution rate in intestinal fluid...
March 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28330303/bio-prospecting-of-cuttle-fish-waste-and-cow-dung-for-the-production-of-fibrinolytic-enzyme-from-bacillus-cereus-ind5-in-solid-state-fermentation
#19
Gurupatham Devadhasan Biji, Arumugaperumal Arun, Eswaran Muthulakshmi, Ponnuswamy Vijayaraghavan, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi
The process parameters governing the production of fibrinolytic enzyme in solid state fermentation employing Bacillus cereus IND5 and using cuttle fish waste and cow dung substrate were optimized. The pH value of the medium, moisture content, sucrose, casein and magnesium sulfate were considered for two-level full factorial design and pH, casein and magnesium sulfate were identified as the important factors for fibrinolytic enzyme production. Central composite design was applied to investigate the interactive effect among variables (pH, casein and magnesium sulfate) and response surface plots were created to find the pinnacle of process response...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330267/treatment-of-landfill-leachate-using-asbr-combined-with-zeolite-adsorption-technology
#20
Chi Kim Lim, Ta Wee Seow, Chin Hong Neoh, Muhamad Hanif Md Nor, Zaharah Ibrahim, Ismail Ware, Siti Hajar Mat Sarip
Sanitary landfilling is the most common way to dispose solid urban waste; however, improper landfill management may pose serious environmental threats through discharge of high strength polluted wastewater also known as leachate. The treatment of landfill leachate to fully reduce the negative impact on the environment, is nowadays a challenge. In this study, an aerobic sequencing batch reactor (ASBR) was proposed for the treatment of locally obtained real landfill leachate with initial ammoniacal nitrogen and chemical oxygen demand (COD) concentration of 1800 and 3200 mg/L, respectively...
December 2016: 3 Biotech
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