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https://www.readbyqxmd.com/read/29241299/nmr-elucidation-of-monomer-dimer-transition-and-conformational-heterogeneity-in-histone-like-dna-binding-protein-of-helicobacter-pylori-hup
#1
Nancy Jaiswal, Nisha Raikwal, Himanshu Pandey, Nipanshu Agarwal, Ashish Arora, Krishna Mohan Poluri, Dinesh Kumar
Helicobacter pylori (H. pylori) colonizes under harsh acidic/oxidative stress conditions of human gastrointestinal tract and can survive there for infinitely longer durations of host life. The bacterium expresses several harbinger proteins to facilitate its persistent colonization under such conditions. One such protein in H. pylori is Histone like DNA binding protein (Hup) which in its homo-dimeric form binds to DNA to perform various DNA dependent cellular activities. Further, it also plays an important role in protecting the genomic DNA from oxidative stress and acidic denaturation...
December 14, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29241218/analysis-of-the-cariogenic-potential-of-various-almond-milk-beverages-using-a-streptococcus-mutans-biofilm-model-in-vitro
#2
Janelle Lee, Janice A Townsend, Tatyana Thompson, Thomas Garitty, Arpan De, Qingzhao Yu, Brian M Peters, Zezhang T Wen
To evaluate the cariogenic properties of almond milk beverages, 6 almond milks, along with soy and whole bovine milk, were analyzed for their abilities to support Streptococcus mutans biofilm formation and acid production, and their capacity to buffer changes in pH. Biofilm formation by S. mutans was analyzed using an in vitro 96-well plate model and measured by crystal violet staining. Acid production by S. mutans was evaluated by a colorimetric L-lactate assay and pH measurement of bacterial cultures. Buffering capacity was assessed by a pH titration assay...
December 15, 2017: Caries Research
https://www.readbyqxmd.com/read/29241129/improving-biocathode-community-multifunctionality-by-polarity-inversion-for-simultaneous-bioelectroreduction-processes-in-domestic-wastewater
#3
Hui Yun, Bin Liang, Deyong Kong, Aijie Wang
Bioelectrochemical systems (BESs) have been tentatively applied for wastewater treatment processes, but the complex composition of wastewater could lead to difficulties in establishing functional biofilm or result in performance instability. Few studies have investigated the enrichment of biocathode with domestic wastewater (DW) and the function. A biocathode with multi-pollutant removal capabilities was enriched based on polarity inverted bioanode, which was established with DW. The biocathode function was examined using model pollutants (nitrate, nitrobenzene and Acid Orange 7) supplemented as sole or mixed electron acceptors...
December 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29241078/heteropolytungstate-decorated-core-shell-magnetic-nanoparticles-a-covalent-strategy-for-polyoxometalate-based-hybrid-nanomaterials
#4
Ourania Makrygenni, Emilie Secret, Aude Michel, Dalil Brouri, Vincent Dupuis, Anna Proust, Jean-Michel Siaugue, Richard Villanneau
Amino-functionalized core-shell magnetic nanoparticles have been covalently grafted with Polyoxometalates (POMs). These multifunctional nanocomposites have been obtained through the coupling of heteropolytungstate-based hybrids bearing carboxylic acid functions with aminopropyl functions that decorate the core-shell nanoparticles. The physical properties of the resulting materials have been studied by a large set of techniques. The very good nanostructuration of the POMs at the surface of the obtained nanoparticles have thus been directly observed by high-resolution transmission electronic microscopy (HR-TEM)...
December 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29241061/scfv-modified-graphene-coated-ide-arrays-for-label-free-screening-of-cardiovascular-disease-biomarkers-in-physiological-saline
#5
Lotta E Delle, Vivek Pachauri, Shikha Sharma, Olena Shaforost, Hui Ma, Mohammad Adabi, Rainer Lilischkis, Patrick Wagner, Ronald Thoelen, Norbert Klein, Richard O'Kennedy, Sven Ingebrandt
Fatty-acid binding proteins (FABP) and myeloperoxidases (MPO) are associated with many chronic conditions in humans and considered to be important biomarkers for diagnosis of cardiac diseases. Here we assemble a new electrical biosensor platform based on graphene-coated interdigitated electrode arrays (IDE-arrays) towards ultrafast, label-free screening of heart type-FABP and MPO. Arrays of nanoscale (nanoIDE) and microscale (microIDE) electrode-arrays were fabricated on wafer-scale by combining nanoimprint and photolithography processes...
December 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29241059/moxidectin-residues-in-lamb-tissues-development-and-validation-of-analytical-method-by-uhplc-ms-ms
#6
Michelle Del Bianchi A Cruz, Maria A M Fernandes, Patricia A de C Braga, Alda L G Monteiro, Daniela Daniel, Felix G R Reyes
The development and validation of a throughput method for the quantitation of moxidectin residues in lamb target tissues (muscle, kidney, liver and fat) was conducted using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). To achieve higher recovery of the analyte from the matrices, a modified QuEChERS method was used for sample preparation. The chromatographic separation was achieved using a Zorbax Eclipse Plus C18 RRHD column with a mobile phase comprising 5mM ammonium formate solution +0...
December 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29241032/biomimetic-elastomeric-conductive-and-biodegradable-polycitrate-based-nanocomposites-for-guiding-myogenic-differentiation-and-skeletal-muscle-regeneration
#7
Yuzhang Du, Juan Ge, Yannan Li, Peter X Ma, Bo Lei
Artificial muscle-like biomaterials have gained tremendous interests owing to their broad applications in regenerative medicine, wearable devices, bioelectronics and artificial intelligence. Unfortunately, key challenges are still existed for current materials, including biomimetic viscoelasticity, biocompatibility and biodegradation, multifunctionality. Herein, for the first time, we develop highly elastomeric, conductive and biodegradable poly (citric acid-octanediol-polyethylene glycol)(PCE)-graphene (PCEG) nanocomposites, and demonstrate their applications in myogenic differentiation and guiding skeletal muscle tissue regeneration...
December 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/29241000/possible-existence-of-%C3%AE-sheets-in-the-amyloid-fibrils-formed-by-a-ttr105-115-mutant
#8
Mary Rose Hilaire, Bei Ding, Debopreeti Mukherjee, Jianxin Chen, Feng Gai
Herein, we combine several methods to characterize the fibrils formed by a TTR105-115 mutant in which Leu111 is replaced by the unnatural amino acid aspartic acid 4-methyl ester. We find that this mutant peptide exhibits significantly different aggregation behavior than the wild-type peptide: (1) it forms fibrils with a much faster rate, (2) its fibrils lack the long-range helical twists observed in TTR105-115 fibrils, (3) its fibrils exhibit a giant far-UV circular dichroism signal, and (4) its fibrils give rise to an unusual amide I' band consisting of four distinct and sharp peaks...
December 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29240946/chemistry-mechanism-and-clinical-status-of-antisense-oligonucleotides-and-duplex-rnas
#9
Xiulong Shen, David R Corey
RNA plays a central role in the expression of all genes. Because any sequence within RNA can be recognized by complementary base pairing, synthetic oligonucleotides and oligonucleotide mimics offer a general strategy for controlling processes that affect disease. The two primary antisense approaches for regulating expression through recognition of cellular RNAs are single-stranded antisense oligonucleotides and duplex RNAs. This review will discuss the chemical modifications and molecular mechanisms that make synthetic nucleic acid drugs possible...
December 12, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29240819/use-of-thermal-analysis-coupled-with-differential-scanning-calorimetry-quadrupole-mass-spectrometry-and-infrared-spectroscopy-tg-dsc-qms-ftir-to-monitor-chemical-properties-and-thermal-stability-of-fulvic-and-humic-acids
#10
Patrycja Boguta, Zofia Sokołowska, Kamil Skic
Thermogravimetry-coupled with differential scanning calorimetry, quadrupole mass spectrometry, and Fourier-transform infrared spectroscopy (TG-DSC-QMS-FTIR)-was applied to monitor the thermal stability (in an N2 pyrolytic atmosphere) and chemical properties of natural polymers, fulvic (FA) and humic acids (HA), isolated from chemically different soils. Three temperature ranges, R1, 40-220°C; R2, 220-430°C; and R3, 430-650°C, were distinguished from the DSC data, related to the main thermal processes of different structures (including transformations without weight loss)...
2017: PloS One
https://www.readbyqxmd.com/read/29240760/novel-linear-motif-filtering-protocol-reveals-the-role-of-the-lc8-dynein-light-chain-in-the-hippo-pathway
#11
Gábor Erdős, Tamás Szaniszló, Mátyás Pajkos, Borbála Hajdu-Soltész, Bence Kiss, Gábor Pál, László Nyitray, Zsuzsanna Dosztányi
Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases. These types of interactions are usually characterized by a specific binding motif that captures the key amino acids shared among the interaction partners. However, the computational proteome-level identification of interaction partners based on the known motif is hindered by the huge number of randomly occurring matches from which biologically relevant motif hits need to be extracted...
December 14, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29240713/nb-based-zeolites-efficient-bi-functional-catalysts-for-the-one-pot-synthesis-of-succinic-acid-from-glucose
#12
Magdi El Fergani, Natalia Candu, Simona M Coman, Vasile I Parvulescu
The one-pot production of succinic acid from glucose was investigated in pure hot water as solvent using Nb (0.02 and 0.05 moles%)-Beta zeolites obtained by a post-synthesis methodology. Structurally, they are comprised of residual framework Al-acid sites, extra-framework isolated Nb (V) and Nb₂O₅ pore-encapsulated clusters. The Nb-modified Beta-zeolites acted as bi-functional catalysts in which glucose is dehydrated to levulinic acid (LA) which, further, suffers an oxidation process to succinic acid (SA)...
December 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29240664/%C3%AE-pyrone-polyketides-from-streptomyces-ambofaciens-bi0048-an-endophytic-actinobacterial-strain-isolated-from-the-red-alga-laurencia-glandulifera
#13
Enikő Rab, Dimitrios Kekos, Vassilios Roussis, Efstathia Ioannou
Four new (1-4) and six previously reported (5-10) α-pyrone polyketides, along with benzoic acid, hydrocinnamic acid, and (E)-cinnamic acid, were isolated from the organic extract resulting from the cultivation of the algicolous strain Streptomyces ambofaciens BI0048, which in turn was isolated from the inner tissues of the red alga Laurencia glandulifera. The structure elucidation of the isolated natural products was based on extensive analysis of their spectroscopic data (NMR, MS, UV, IR). Compounds 1-10 were evaluated for their antibacterial and cytotoxic activities against two multidrug-resistant strains of Staphylococcus aureus and one strain of Escherichia coli, as well as two human cancer cell lines...
December 14, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29240444/regio-and-diastereodivergent-4-2-cycloadditions-with-cyclic-2-4-dienones
#14
Wei Xiao, Qian-Qian Yang, Zhi Chen, Qin Ouyang, Wei Du, Ying-Chun Chen
By employing activated alkenes with bulky α-functional groups, such as α-cyano-α,β-unsaturated ketones and Meldrum's acid-based alkenes, a previously unreported cross-trienamine pathway of cyclic 2,4-dienones is adopted to deliver γ',δ-regioselective [4 + 2] cycloadducts catalyzed by cinchona-derived amines. In addition, a diastereodivergent [4 + 2] cycloaddition reaction is realized with Z-configured 4-alkylideneisoxazol-5(4H)-ones under similar catalytic conditions, even through a three- or four-component cascade process with simple starting materials...
December 14, 2017: Organic Letters
https://www.readbyqxmd.com/read/29240337/nucleic-acid-diagnostic-approaches-in-parasitology
#15
Anne-Marie Kerttula, Antti Lavikainen
Nucleic acid diagnostic technologies are partly replacing traditional microscopy and antigen detection methods in parasitological diagnostics. In particular, the diagnostics of parasitic diarrhea is undergoing a transformation due to the application of polymerase chain reaction (PCR) tests. Diagnostics of malaria is still based on microscopy, but rapid nucleic acid tests are emerging. Laboratories of clinical microbiology in Finland currently provide PCR tests e.g. for intestinal protozoa, Toxoplasma and Trichomonas...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29240307/use-and-limitations-of-offsite-consequence-analysis-tools-from-south-korea-and-the-united-states-in-hydrogen-fluoride-accidental-release
#16
Min-Uk Kim, Sang-Hoon Byeon
We investigated the characteristics and limitations in the event of hydrofluoric acid (HF) leakage by comparing and analyzing of the offsite consequence analysis (OCA) tools based on the chemical plant operating conditions. We reviewed the tools Korea Offsite Risk Assessment (KORA) from South Korea and RMP*CompTM and Areal Location of Hazardous Atmospheres (ALOHA) from the United States. The scenario studied was based on a leak event from a 50% HF aqueous solution storage tank, and the operating conditions taken into consideration were the operating temperature and dike installation conditions...
December 14, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29240294/achieving-efficient-electrocatalytic-hydrogen-evolution-activity-based-on-ultrafine-and-highly-dispersed-rupx-encapsulated-in-n-p-co-doped-hollow-carbon-nanospheres
#17
Jing-Qi Chi, Wen-Kun Gao, Jia-Hui Lin, Bin Dong, Kai-Li Yan, Jun-Feng Qin, Bin Liu, Yong-Ming Chai, Chen-Guang Liu
The ultrafine RuPx nanoparticles (NPs) encapsulated in uniform N, P co-doped hollow carbon nanospheres (RuPx@NPC) have been synthesized through a facile route of using aniline-pyrrole polymer nanospheres to disperse Ru ions with followed gas phosphorization process. The as-prepared RuPx@NPC exhibits uniform core-shell hollow nanospherical structures with ultrafine RuPx NPs as core and N, P co-doped carbon (NPC) as shell. So this strategy integrates many advantages of designing hollow nanostructures, providing conductive substrate and doping non-metal element...
December 14, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29240289/dnazyme-feedback-amplification-relaying-molecular-recognition-to-exponential-dna-amplification
#18
Meng Liu, Qingxin Yin, Erin McConnell, Yangyang Chang, John Brennan, Yingfu Li
Technologies capable of linking DNA amplification to molecular recognition are very desirable for ultrasensitive biosensing applications. We have developed a simple but powerful isothermal DNA amplification method, termed DNAzyme feedback amplification (DFA), that is capable of relaying molecular recognition to exponential DNA amplification. The method incorporates both an RNA-cleaving DNAzyme (RCD) and rolling circle amplification (RCA) carried out by a special DNA polymerase using a circular DNA template...
December 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29240245/structure-and-composition-of-unio-pictorum-shell-arguments-for-the-diversity-of-the-nacroprismatic-arrangement-in-molluscs
#19
Y Dauphin, G Luquet, M Salome, L Bellot-Gurlet, J P Cuif
Mollusc shells are complex organomineral structures, the arrangement and composition depending on the species. Most studies are dedicated to shells composed of an aragonite nacreous and a calcite prismatic layer, so the nacreous prismatic model based on Pinctada and Atrina-Pinna. Here, we studied the micro- and nanostructure, the mineralogy and composition of a nacroprismatic bivalve species: Unio pictorum. The prismatic layer of Unio is aragonite, and the inner structure of the prismatic units strongly differs from those of the calcitic layers...
December 14, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/29240238/evaluation-of-microfiltration-and-heat-treatment-on-the-microbiological-characteristics-phenolic-composition-and-volatile-compounds-profile-of-pomegranate-juice-punica-granatum-l
#20
REVIEW
Antonio Colantuono, Paola Vitaglione, Nadia Manzo, Giuseppe Blaiotta, Immacolata Montefusco, Andrea Marrazzo, Fabiana Pizzolongo, Raffaele Romano
BACKGROUND: Since processing technology and storage may influence both sensory and nutritional value as well as the shelf-life of pomegranate juice (PJ), mild technologies based on microfiltration may be a promising alternative to heat treatments for fruit juices preservation. In this study, physico-chemical and microbiological properties of raw (RPJ), microfiltered (MPJ) and cloudy pasteurized PJ (PPJ) were compared over a period of 4 weeks. RESULTS: Data demonstrated that microfiltration was comparable to pasteurization in guarantying the microbiological stability of the juice avoiding spoilage of the final product...
December 14, 2017: Journal of the Science of Food and Agriculture
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