keyword
MENU ▼
Read by QxMD icon Read
search

Acid Base

keyword
https://www.readbyqxmd.com/read/29031148/fabrication-of-charge-reversible-graphene-oxide-based-nanocomposite-with-multiple-antibacterial-modes-and-magnetic-recyclability
#1
Qiang Li, Chunyan Yong, Weiwei Cao, Xi Wang, Lina Wang, Jie Zhou, Xiaodong Xing
In this work, N-alkylated poly (4-vinylpyridine) (NPVP), a cationic polymer, was firstly applied for the surface modification of Fe3O4 nanoparticles. Then the modified Fe3O4 nanoparticles (Fe3O4@NPVP NPs) combined with graphene oxide (GO) through simple electrostatic binding. Subsequently, deposited Ag nanoparticles (Ag NPs) procedure was carried out to form the multiple antibacterial nanocomposites (GO-Fe3O4@NPVP-Ag). The synthesized nanostructures were well characterized by Transmission Electron Microscope (TEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) and Raman spectroscopy...
October 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29031128/electrochemically-mediated-in-situ-growth-of-electroactive-polymers-for-highly-sensitive-detection-of-double-stranded-dna-without-sequence-preference
#2
Qiong Hu, Qiangwei Wang, Jinming Kong, Lianzhi Li, Xueji Zhang
The ability to directly detect double-stranded DNA (dsDNA) without sequence-preference continues to be a major challenge. Herein, we report an electrochemical method for the direct, highly sensitive detection of dsDNA based on the strand replacement of dsDNA by peptide nucleic acid (PNA) and the in situ growth of electroactive polymers through the surface-initiated electrochemically mediated atom transfer radical polymerization (SI-eATRP). Thiolated PNA molecules are firstly self-assembled onto gold electrode surface for the specific recognition of target dsDNA (dsDNA-T), which in turn leads to the formation of a high density of PNA/DNA heteroduplexes on the electrode surface for the subsequent attachment of ATRP initiators via the phosphate-Zr(4+)-carboxylate chemistry...
September 28, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29031116/evaluation-of-fluoride-bioremediation-and-production-of-biomolecules-by-living-cyanobacteria-under-fluoride-stress-condition
#3
Gargi Biswas, Sohini Guha Thakurta, Jitamanyu Chakrabarty, Kalyan Adhikari, Susmita Dutta
Application of microalgae for defluoridation has gained interest in recent years. In the present study, bioremediation of fluoride using living cyanobacteria, Starria zimbabweensis, collected from wastewater of coke-oven effluent treatment plant, Durgapur, India, has been investigated. Initially, the cyanobacterial strain was grown in BG11 medium at 25°C, 45μmol/m(2)/s irradiation in 18h: 6h light:dark cycle in an algal incubator. Samples were withdrawn after 2 days interval and analyzed for its dry biomass and lipid content...
October 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29031075/discovery-of-new-indomethacin-based-analogs-with-potentially-selective-cyclooxygenase-2-inhibition-and-observed-diminishing-to-pge2-activities
#4
Shaymaa E Kassab, Mohammed A Khedr, Hamed I Ali, Mohamed M Abdalla
New ring-extended analogs of indomethacin were designed based on the structure of active binding site of both COX-1 and COX-2 isoenzymes and the interaction pattern required for selective inhibition of COX-2 to improve its selectivity against COX-2. The strategy adopted for designing the new inhibitors involved i) ring extension of indomethacin to reduce the possibility of analogs to be accommodated into the narrow hydrophobic tunnel of COX-1, ii) deletion of carboxylic acid to reduce the possibility of inhibitor to form salt bridge with Arg120 and eventually prevent COX-1 inhibition, and iii) introduction of methylsulfonyl group to increase the opportunity of the analogs to interact with the polar side pocket that's is crucial for inhibition process of COX-2...
September 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031074/synthesis-antiproliferative-anti-tubulin-activity-and-docking-study-of-new-1-2-4-triazoles-as-potential-combretastatin-analogues
#5
Muhamad Mustafa, Dalia Abdelhamid, ElShimaa M N Abdelhafez, Mahmoud A A Ibrahim, Amira M Gamal-Eldeen, Omar M Aly
Combretastatin A4 (CA4) is a natural product characterized by a powerful inhibition of tubulin polymerization and a potential anticancer activity. However, therapeutic application of CA4 is substantially hindered due to geometric isomerization. In the current study, new cis-restricted Combretastatin A4 analogues containing 1,2,4-triazle in place of the olefinic bond were designed and synthesized. The synthesized compounds were evaluated for their in vitro antiproliferative activity in human hepatocellular carcinoma HepG2 and leukemia HL-60 cell lines using MTT assay...
September 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031070/nature-based-molecules-combined-with-rivastigmine-a-symbiotic-approach-for-the-synthesis-of-new-agents-against-alzheimer-s-disease
#6
Giulia Nesi, Qiuhe Chen, Simona Sestito, Maria Digiacomo, Xiaohong Yang, Shengnan Wang, Rongbiao Pi, Simona Rapposelli
Starting from nature as original source, new potential agents with pleiotropic activities have been synthesized and evaluated as neuroprotective agents. In this work, novel nature-based hybrids, combining antioxidant motifs with rivastigmine, have been designed and synthesized. The biological results revealed that the new compounds inhibit both AChE and BuChE. In particular, lipoic acid hybrids LA1, LA2, LA3 resulted to be the most potent inhibitors of BuChE showing IC50 values ranging from 340 to 378 nM. Analogously, all the compounds were able to inhibit the self β-amyloid1-42 aggregation...
October 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29029339/targeted-enrichment-of-large-gene-families-for-phylogenetic-inference-phylogeny-and-molecular-evolution-of-photosynthesis-genes-in-the-portullugo-clade-caryophyllales
#7
Abigail J Moore, Jurriaan M de Vos, Lillian P Hancock, Eric Goolsby, Erika J Edwards
Hybrid enrichment is an increasingly popular approach for obtaining hundreds of loci for phylogenetic analysis across many taxa quickly and cheaply. The genes targeted for sequencing are typically single-copy loci, which facilitate a more straightforward sequence assembly and homology assignment process. However, this approach limits the inclusion of most genes of functional interest, which often belong to multi-gene families. Here we demonstrate the feasibility of including large gene families in hybrid enrichment protocols for phylogeny reconstruction and subsequent analyses of molecular evolution, using a new set of bait sequences designed for the "portullugo" (Caryophyllales), a moderately sized lineage of flowering plants (∼2200 species) that includes the cacti and harbors many evolutionary transitions to C4 and CAM photosynthesis...
September 25, 2017: Systematic Biology
https://www.readbyqxmd.com/read/29029330/the-association-between-omega-3-fatty-acid-biomarkers-and-inflammatory-arthritis-in-an-anti-citrullinated-protein-antibody-positive-population
#8
Ryan W Gan, Elizabeth A Bemis, M Kristen Demoruelle, Christopher C Striebich, Stacey Brake, Marie L Feser, LauraKay Moss, Michael Clare-Salzler, V Michael Holers, Kevin D Deane, Jill M Norris
Objectives: Higher circulating omega-3 fatty acids (n-3 FAs) are associated with a lower prevalence of anti-CCP antibodies and RF in subjects without RA. We examined whether, in anti-CCP+ subjects, n-3 FAs also play a role in development of inflammatory arthritis (IA). Methods: At Colorado-based health fairs from 2008 to 2014, participants without a previous diagnosis of RA who were anti-CCP3+ (n = 47) were recruited into a follow-up study; symptom assessments and joint examinations were conducted every 6 months for the determination of IA...
October 4, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029322/a-dynamic-mathematical-model-of-bile-acid-clearance-in-heparg-cells
#9
Daniel Kaschek, Ahmad Sharanek, André Guillouzo, Jens Timmer, Richard J Weaver
A dynamic model based on ordinary differential equations that describes uptake, basolateral and canalicular export of taurocholic acid in human HepaRG cells is presented. The highly reproducible inter-assay experimental data were used to reliably estimate model parameters. Primary human hepatocytes were similarly evaluated to establish a mathematical model, but with notably higher inter-assay differences in taurocholic acid clearance and bile canaliculi dynamics. By use of the HepaRG cell line, the simultaneous taurocholic acid clearance associated to basolateral uptake, canalicular and sinusoidal efflux, was predicted...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029248/efficacy-of-nanoencapsulated-thymus-eriocalyx-and-thymus-kotschyanus-essential-oils-by-a-mesoporous-material-mcm-41-against-tetranychus-urticae-acari-tetranychidae
#10
Asgar Ebadollahi, Jalal Jalali Sendi, Alireza Aliakbar
Inspite of well-established potentiality of plant essential oils as biopesticides, their environmentally low persistence is considered as a hindering obstacle for its commercialization. In the present study, chemical composition and toxicity of essential oils isolated from leaves of Thymus eriocalyx and Thymus kotschyanus were evaluated against two-spotted spider mite, Tetranychus urticae. The chemicals present in the crude oil were found to be thymol (28.83%), oleic acid (11.51%), palmitic acid (8.60%), borneol (5...
September 27, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29029205/transcriptome-analysis-of-the-triatoma-infestans-hemiptera-reduviidae-integument
#11
Gustavo M Calderón-Fernández, Débora E Moriconi, Andrea B Dulbecco, M Patricia Juárez
The insect integument, formed by the cuticle and the underlying epidermis, is essential for insect fitness, regulation of lipid biosynthesis and storage, insect growth and feeding, together with development progress. Its participation in insecticide resistance has also been outlined. Triatoma infestans Klug (Hemiptera: Reduviidae) is one of the major vectors of Chagas disease in South America; however, genomic data are scarce. In this study, we performed a transcriptome analysis of the nymph integument in order to identify which genes are expressed and their putative role...
September 27, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029129/a-visual-review-of-the-human-pathogen-streptococcus-pneumoniae
#12
Ditte Høyer Engholm, Mogens Kilian, David S Goodsell, Ebbe Sloth Andersen, Rikke Schmidt Kjærgaard
Being the principal causative agent of bacterial pneumonia, otitis media, meningitis and septicemia, the bacterium Streptococcus pneumoniae is a major global health problem. To highlight the molecular basis of this problem, we have portrayed essential biological processes of the pneumococcal life cycle in eight watercolor paintings. The paintings are done to a consistent nanometer scale based on currently available data from structural biology and proteomics. In this review article, the paintings are used to provide a visual review of protein synthesis, carbohydrate metabolism, cell wall synthesis, cell division, teichoic acid synthesis, virulence, transformation and pilus synthesis based on the available scientific literature within the field of pneumococcal biology...
October 5, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29028909/the-systematic-analysis-of-ultraconserved-genomic-regions-in-the-budding-yeast
#13
Zhi-Kai Yang, Feng Gao
Motivation: In the evolution of species, a kind of special sequences, termed ultraconserved sequences (UCSs), have been inherited without any change, which strongly suggests those sequences should be crucial for the species to survive or adapt to the environment. However, the UCSs are still regarded as mysterious genetic sequences so far. Here, we present a systematic study of ultraconserved genomic regions in the budding yeast based on the publicly available genome sequences, in order to reveal their relationship with the adaptability or fitness advantages of the budding yeast...
September 27, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028877/rinspector-a-cytoscape-app-for-centrality-analyses-and-dynamine-flexibility-prediction
#14
Guillaume Brysbaert, Kevin Lorgouilloux, Wim Vranken, Marc F Lensink
Motivation: Protein function is directly related to amino acid residue composition and the dynamics of these residues. Centrality analyses based on residue interaction networks permit to identify key residues in a protein that are important for its fold or function. Such central residues and their environment constitute suitable targets for mutagenesis experiments. Predicted flexibility and changes in flexibility upon mutation provide valuable additional information for the design of such experiments...
September 22, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028839/interaction-of-the-human-respiratory-syncytial-virus-matrix-protein-with-cellular-adaptor-protein-complex-3-plays-a-critical-role-in-trafficking
#15
Casey Ward, Maciej Maselko, Christopher Lupfer, Meagan Prescott, Manoj K Pastey
Human Respiratory Syncytial Virus (HRSV) is a leading cause of bronchopneumonia in infants and the elderly. To date, knowledge of viral and host protein interactions within HRSV is limited and are critical areas of research. Here, we show that HRSV Matrix (M) protein interacts with the cellular adaptor protein complex 3 specifically via its medium subunit (AP-3Mu3A). This novel protein-protein interaction was first detected via yeast-two hybrid screen and was further confirmed in a mammalian system by immunofluorescence colocalization and co-immunoprecipitation...
2017: PloS One
https://www.readbyqxmd.com/read/29028822/serial-omics-characterization-of-equine-urine
#16
Min Yuan, Susanne B Breitkopf, John M Asara
Horse urine is easily collected and contains molecules readily measurable using mass spectrometry that can be used as biomarkers representative of health, disease or drug tampering. This study aimed at analyzing microliter levels of horse urine to purify, identify and quantify proteins, polar metabolites and non-polar lipids. Urine from a healthy 12 year old quarter horse mare on a diet of grass hay and vitamin/mineral supplements with limited pasture access was collected for serial-omics characterization. The urine was treated with methyl tert-butyl ether (MTBE) and methanol to partition into three distinct layers for protein, non-polar lipid and polar metabolite content from a single liquid-liquid extraction and was repeated two times...
2017: PloS One
https://www.readbyqxmd.com/read/29028616/simultaneous-determination-of-a-novel-c-met-axl-dual-target-small-molecule-inhibitor-bpi-9016m-and-its-metabolites-in-human-plasma-by-liquid-chromatography-tandem-mass-spectrometry-application-in-a-pharmacokinetic-study-in-chinese-advanced-solid-tumor-patients
#17
Xinge Cui, Xin Zheng, Ji Jiang, Fenlai Tan, Lieming Ding, Pei Hu
BPI-9016M is a novel dual-target small-molecule inhibitor targeting c-Met and AXL, which was developed by Betta Pharmaceuticals Co., Ltd (Hangzhou, China). It has great potential in the treatment of advanced cancer. A high throughput quantitation method, based on liquid chromatography-tandem mass spectrometry, was developed and validated for the simultaneous determination of BPI-9016M and its main metabolite, M1 and M2-2, in human plasma with a sample preparation method of precipitation of protein. Liquid chromatographic separation was performed with a gradient elution of formic acid-10mM ammonium acetate aqueous solution (1:1000, v/v) and acetonitrile at a flow rate of 0...
October 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29028609/daunorubicin-and-doxorubicin-molecular-interplay-with-2d-membrane-models
#18
Ana Catarina Alves, Cláudia Nunes, José Lima, Salette Reis
The anthracyclines daunorubicin and doxorubicin are widely used antineoplastic agents due to their therapeutic activity against a broad variety of human cancers. Although, the classical model to explain anthracyclines' cytotoxicity has been based in the direct interference with nucleic acid function, evidence suggests that the plasma membrane is also involved in the drug's mechanism of action. In this work, the interaction of these drugs with two-dimensional membrane models were studied in order to gain further insights at the molecular level regarding anthracyclines membrane interactions...
October 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29028573/the-first-protection-free-synthesis-of-magnetic-bifunctional-l-proline-as-a-highly-active-and-versatile-artificial-enzyme-synthesis-of-imidazole-derivatives
#19
Hamideh Aghahosseini, Ali Ramazani, Katarzyna Ślepokura, Tadeusz Lis
l-Proline is a bifunctional versatile organocatalyst that could promote a variety of useful transformations. Some passive and dynamic interactions between this simple amino acid and different substrates, which are necessary to enzymatic reactions, have given it "the simplest enzyme" title. Herein we presented the first report on the synthesis of magnetic bifunctional l-proline as an artificial enzyme without requiring any protection/deprotection steps according to an operationally simple process. This magnetic nano-biocatalyst is a promising catalyst that in a case study was successfully applied for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles in the 70-99% and 60-90% yields respectively, which it could be extended to the variety of l-proline-based organic transformations...
October 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29028346/influence-of-hofmeister-i-on-tuning-optoelectronic-properties-of-ampholytic-polythiophene-by-varying-ph-and-conjugating-with-rna
#20
Radhakanta Ghosh, Dhruba P Chatterjee, Sujoy Das, Titas Kumar Mukhopadhyay, Ayan Datta, Arun K Nandi
A significant tuning of optoelectronic properties of polythiophene (PT) chains due to Hofmeister iodide (I-) ion is demonstrated in ampholytic polythiophene [polythiophene-g-poly{(N,N,N-trimethylamino iodide)ethyl methacrylate-co-methacrylic acid}, APT] at different pH. In acidic medium, the absorption and emission signals of PT chromophore exhibit appreciable blue shift in presence of I- as counter anion only. The co-operative effect of undissociated -COOH and quaternary ammonium groups immobilize I- near apolar PT chain causing threading of grafted chains and hence twisting of the backbone attributing to the blue shift...
October 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
keyword
keyword
14078
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"