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Cerebrovascular reactivity

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https://www.readbyqxmd.com/read/29739462/effect-of-hyperlipidemia-on-the-incidence-of-cardio-cerebrovascular-events-in-patients-with-type-2-diabetes
#1
Dabei Fan, Li Li, Zhizhen Li, Ying Zhang, Xiaojun Ma, Lina Wu, Guijun Qin
BACKGROUND: This study was to explore the effect of hyperlipidemia on the incidence of cardio-cerebrovascular diseases in patients with type 2 diabetes. METHODS: Three hundred ninety five patients with type 2 diabetes in our hospital from January 2012 to January 2016 were followed up with an average of 3.8 years. The incidence of cardio-cerebrovascular diseases between diabetes combined with hyperlipidemia group (195 patients) and diabetes group (200 patients) were made a comparison...
May 8, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29726891/understanding-the-role-of-the-perivascular-space-in-cerebral-small-vessel-disease
#2
Rosalind Brown, Helene Benveniste, Sandra E Black, Serge Charpak, Martin Dichgans, Anne Joutel, Maiken Nedergaard, Kenneth J Smith, Berislav V Zlokovic, Joanna M Wardlaw
Small vessel diseases are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins. Of the 35-36 million people that are estimated to suffer from dementia worldwide, up to 65% have an SVD component. Furthermore, SVD causes 20-25% of strokes, worsens outcome after stroke and is a leading cause of disability, cognitive impairment and poor mobility. Yet the underlying cause(s) of SVD are not fully understood.Magnetic resonance imaging (MRI) has confirmed enlarged perivascular spaces (PVS) as a hallmark feature of SVD...
May 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29687902/impact-of-metabolic-diseases-on-cerebral-circulation-structural-and-functional-consequences
#3
Maha Coucha, Mohammed Abdelsaid, Rebecca Ward, Yasir Abdul, Adviye Ergul
Metabolic diseases including obesity, insulin resistance, and diabetes have profound effects on cerebral circulation. These diseases not only affect the architecture of cerebral blood arteries causing adverse remodeling, pathological neovascularization, and vasoregression but also alter the physiology of blood vessels resulting in compromised myogenic reactivity, neurovascular uncoupling, and endothelial dysfunction. Coupled with the disruption of blood brain barrier (BBB) integrity, changes in blood flow and microbleeds into the brain rapidly occur...
March 25, 2018: Comprehensive Physiology
https://www.readbyqxmd.com/read/29687019/phosphodiesterase-5-inhibition-potentiates-cerebrovascular-reactivity-in-chronic-traumatic-brain-injury
#4
Kimbra Kenney, Franck Amyot, Carol Moore, Margalit Haber, L Christine Turtzo, Christian Shenouda, Erika Silverman, Yunhua Gong, Bao-Xi Qu, Leah Harburg, Eric M Wassermann, Hanzhang Lu, Ramon Diaz-Arrastia
Background: Traumatic cerebrovascular injury (TCVI), a common consequence of traumatic brain injury (TBI), presents an attractive therapeutic target. Because phosphodiesterase-5 (PDE5) inhibitors potentiate the action of nitric oxide (NO) produced by endothelial cells, they are candidate therapies for TCVI. This study aims to: (1) measure cerebral blood flow (CBF), cerebrovascular reactivity (CVR), and change in CVR after a single dose of sildenafil (ΔCVR) in chronic TBI compared to uninjured controls; (2) examine the safety and tolerability of 8-week sildenafil administration in chronic symptomatic moderate/severe TBI patients; and as an exploratory aim, (3) assess the effect of an 8-week course of sildenafil on chronic TBI symptoms...
April 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29686027/10-year-associations-between-tumor-necrosis-factor-receptors-1-and-2-and-cardiovascular-events-in-patients-with-stable-coronary-heart-disease-a-claricor-effect-of-clarithromycin-on-mortality-and-morbidity-in-patients-with-ischemic-heart-disease-trial-substudy
#5
Axel C Carlsson, Toralph Ruge, Erik Kjøller, Jørgen Hilden, Hans Jørn Kolmos, Ahmad Sajadieh, Jens Kastrup, Gorm Boje Jensen, Anders Larsson, Christoph Nowak, Janus Christian Jakobsen, Per Winkel, Christian Gluud, Johan Ärnlöv
BACKGROUND: We aimed to assess the associations and predictive powers between the soluble receptors for tumor necrosis factor (TNF)-α (TNFR1 and TNFR2) and cardiovascular outcomes in patients with stable coronary heart disease. METHODS AND RESULTS: CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) is a randomized clinical trial comparing clarithromycin with placebo in patients with stable coronary heart disease...
April 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29681886/importance-of-collateralization-in-patients-with-large-artery-intracranial-occlusive-disease-long-term-longitudinal-assessment-of-cerebral-hemodynamic-function
#6
Larissa McKetton, Lakshmikumar Venkatraghavan, Julien Poublanc, Olivia Sobczyk, Adrian P Crawley, Casey Rosen, Frank L Silver, James Duffin, Joseph A Fisher, David J Mikulis
Patients with large artery intracranial occlusive disease (LAICOD) are at risk for both acute ischemia and chronic hypoperfusion. Collateral circulation plays an important role in prognosis, and imaging plays an essential role in diagnosis, treatment planning, and prognosis of patients with LAICOD. In addition to standard structural imaging, assessment of cerebral hemodynamic function is important to determine the adequacy of collateral supply. Among the currently available methods of assessment of cerebral hemodynamic function, measurement of cerebrovascular reactivity (CVR) using blood oxygen level-dependent (BOLD) MRI and precisely controlled CO2 has shown to be a safe, reliable, reproducible, and clinically useful method for long-term assessment of patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29665789/idiopathic-basal-ganglia-calcification-associated-with-cerebral-micro-infarcts-a-case-report
#7
Takuma Nishimoto, Fumiaki Oka, Hideyuki Ishihara, Mizuya Shinoyama, Michiyasu Suzuki
BACKGROUND: Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition. We report a patient with IBGC associated with cerebral infarction due to impairment of cerebrovascular reactivity based on single-photon emission computed tomography (SPECT) with acetazolamide challenge. CASE PRESENTATION: A 66-year-old male presented with right conjugate deviation, right hemiparesis and total aphasia due to a convulsive seizure...
April 17, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29649969/magnetic-resonance-imaging-for-assessment-of-cerebrovascular-reactivity-and-its-relationship-to-cognition-a-systematic-review
#8
Sarah J Catchlove, Andrew Pipingas, Matthew E Hughes, Helen Macpherson
BACKGROUND: Cerebrovascular reactivity (CVR) refers to the responsiveness of cerebral vasculature to vasoactive stimuli. CVR is an indicator of brain health and can be assessed using vasodilatory techniques and magnetic resonance imaging (MRI). Using such approaches, some researchers have explored the relationship between CVR and cognition; here we systematically review this work. RESULTS: We extracted information pertaining to: (1) study location and design, participant characteristics, sample sizes, (2) design of vascular challenge, end-tidal CO 2 (etCO 2 ) concentrations (if applicable), (3) MRI protocol, (4) cognitive assessment, (5) CVR values, and outcomes of statistical analyses with cognitive tests...
April 12, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29629537/different-associations-of-plasma-biomarkers-in-alzheimer-s-disease-mild-cognitive-impairment-vascular-dementia-and-ischemic-stroke
#9
Jingwei Shang, Toru Yamashita, Yusuke Fukui, Dongjing Song, Xianghong Li, Yun Zhai, Yumiko Nakano, Ryuta Morihara, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe
BACKGROUND AND PURPOSE: Cognitive and cerebrovascular diseases are common in the elderly, but differences in the plasma levels and associations of plasma biomarkers in these diseases remain elusive. METHODS: The present study investigated differences in plasma fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], adiponectin, reptin, plasma markers of inflammation [high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (serum AA)], and plasma lipids [high-density lipoprotein and low-density lipoprotein (LDL)] in patients with Alzheimer's disease (AD) (n=266), mild cognitive impairment (MCI) (n=44), vascular dementia (VaD) (n=33), and ischemic stroke (IS) (n=200) in comparison to normal controls (n=130)...
January 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29593520/iclinfmri-software-for-integrating-functional-mri-techniques-in-presurgical-mapping-and-clinical-studies
#10
Ai-Ling Hsu, Ping Hou, Jason M Johnson, Changwei W Wu, Kyle R Noll, Sujit S Prabhu, Sherise D Ferguson, Vinodh A Kumar, Donald F Schomer, John D Hazle, Jyh-Horng Chen, Ho-Ling Liu
Task-evoked and resting-state (rs) functional magnetic resonance imaging (fMRI) techniques have been applied to the clinical management of neurological diseases, exemplified by presurgical localization of eloquent cortex, to assist neurosurgeons in maximizing resection while preserving brain functions. In addition, recent studies have recommended incorporating cerebrovascular reactivity (CVR) imaging into clinical fMRI to evaluate the risk of lesion-induced neurovascular uncoupling (NVU). Although each of these imaging techniques possesses its own advantage for presurgical mapping, a specialized clinical software that integrates the three complementary techniques and promptly outputs the analyzed results to radiology and surgical navigation systems in a clinical format is still lacking...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29580963/neurovascular-coupling-during-visual-stimulation-in-multiple-sclerosis-a-meg-fmri-study
#11
Rachael Stickland, Marek Allen, Lorenzo Magazzini, Krish D Singh, Richard G Wise, Valentina Tomassini
The process of neurovascular coupling ensures that increases in neuronal activity are fed by increases in cerebral blood flow. Evidence suggests that neurovascular coupling may be impaired in multiple sclerosis (MS) due to a combination of brain hypoperfusion, altered cerebrovascular reactivity and oxygen metabolism, and altered levels of vasoactive compounds. Here, we tested the hypothesis that neurovascular coupling is impaired in MS. We characterised neurovascular coupling as the relationship between changes in neuronal oscillatory power within the gamma frequency band (30-80 Hz), as measured by magnetoencephalography (MEG), and associated haemodynamic changes (blood oxygenation level dependent, BOLD, and cerebral blood flow, CBF)as measured by functional MRI...
March 23, 2018: Neuroscience
https://www.readbyqxmd.com/read/29580034/risk-factors-biomarkers-etiology-outcome-and-prognosis-of-ischemic-stroke-in-cancer-patients
#12
Mine Hayriye Sorgun, Muge Kuzu, Inci Sule Ozer, Volkan Yilmaz, Cagrı Ulukan, Hafize Cotur Levent, Sabiha Tezcan, Sefer Rzayev, Anwar Rawandi, Batuhan Bakırarar, Canan Togay Isikay
Introduction: Cerebrovascular disease is the second most common complication in individuals with tumours. The aim of this study was to investigate risk factors, biomarkers, etiology and prognosis of ischemic stroke in cancer patients (ISCPs). Methods: The medical records of 619 consecutive patients who were admitted with acute ischemic stroke from January 2012 to November 2014 were retrospectively evaluated. The patients were divided into two groups (group 1, patients with an active cancer prior to the onset of ischemic stroke; group 2, patients without an active cancer history)...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29578488/risk-factors-associated-with-cortical-thickness-and-white-matter-hyperintensities-in-dementia-free-okinawan-elderly
#13
Lisa C Silbert, David Lahna, Nutta-On Promjunyakul, Erin Boespflug, Yusuke Ohya, Yasushi Higashiuesato, Junko Nishihira, Yuriko Katsumata, Takashi Tokashiki, Hiroko Dodge
BACKGROUND: Cortical gray matter (GM) and white matter (WM) deterioration are signals of neurodegeneration and increased dementia risk; however, their specific etiologies in dementia-free aging is unclear. OBJECTIVE: The objective of this study was to examine potentially modifiable risk factors of GM and WM degeneration in a well-characterized cohort of dementia-free elderly. METHODS: 96 Okinawan elderly participants (age 83.6) from the Keys to Optimal Cognitive Aging Project (KOCOA) underwent MRI and cognitive evaluation...
March 23, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29575939/mechanism-of-malat1-preventing-apoptosis-of-vascular-endothelial-cells-induced-by-oxygen-glucose-deficiency-and-reoxidation
#14
Guoping Wang, Yuanbo Wu, Yuyou Zhu
BACKGROUND: Cerebral ischemia/reperfusion (I/R) injury leads to cerebrovascular dysfunction characterized by endothelial cell injury or death. Metastasis-associated lung adenocarcinoma transcript 1(MALAT1) has been reported to be associated with endothelial dysfunction. Our study aimed to investigate the effect of MALAT1 on vascular endothelium. METHODS: In this study, oxygen-glucose deprivation and reoxygenation (OGD-R) were used as in vitro studies to investigate the role of MALAT1 in I/R-induced apoptosis of cerebrovascular endothelial cells in an I/R injury model...
March 26, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29574034/cerebrovascular-reactivity-cvr-mri-with-co2-challenge-a-technical-review
#15
Peiying Liu, Jill De Vis, Hanzhang Lu
Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular reserve and provides important information about vascular health in a range of brain conditions and diseases. Unlike steady-state vascular parameters, such as cerebral blood flow (CBF) and cerebral blood volume (CBV), CVR measures the ability of cerebral vessels to dilate or constrict in response to challenges or maneuvers. Therefore, CVR mapping requires a physiological challenge while monitoring the corresponding hemodynamic changes in the brain...
March 21, 2018: NeuroImage
https://www.readbyqxmd.com/read/29568934/tanshinone%C3%A2-iia-attenuates-the-deleterious-effects-of-oxidative-stress-in-osteoporosis-through-the-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway
#16
Shaowen Zhu, Wanfu Wei, Zhiwei Liu, Yang Yang, Haobo Jia
Osteoclasts are responsible for bone resorption caused by bone microstructural damage and bone-related disorders. Evidence shows that tanshinone IIA (Tan‑IIA), a traditional Chinese medicine, is used clinically as a drug for the treatment of cardiovascular and cerebrovascular diseases. However, the efficacy and mechanism underlying the effect of Tan‑IIA on the viability of osteoclasts remain to be fully elucidated. The present study investigated the therapeutic effects of Tan‑IIA on osteoblast differentiation and oxidative stress in vitro and in vivo...
March 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29567504/age-related-changes-in-cerebrovascular-reactivity-and-their-relationship-to-cognition-a-four-year-longitudinal-study
#17
Shin-Lei Peng, Xi Chen, Yang Li, Karen M Rodrigue, Denise C Park, Hanzhang Lu
Although cerebrovascular factors are the second leading cause of cognitive impairment and dementia in elderly, the precise spatial and temporal trajectories of vascular decline in aging have not been fully characterized. With an advanced cerebrovascular reactivity (CVR) MRI technique that specifically informs vascular stiffness and dilatory ability of cerebral vessels, we present four-year longitudinal CVR data measured in 116 healthy individuals (20-88 years of age). Our data revealed a spatial heterogeneity in vascular decline in aging (p = 0...
March 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29566286/the-breath-hold-acceleration-index-a-new-method-to-evaluate-cerebrovascular-reactivity-using-transcranial-doppler
#18
Mohammed Alwatban, Edward J Truemper, Abdullah Al-Rethaia, Daniel L Murman, Gregory R Bashford
BACKGROUND AND PURPOSE: Cerebrovascular reactivity (CR) is an ideal biomarker to detect cerebrovascular damage. CR can be quantified by measuring changes in cerebral blood flow velocity (CBFV) resulting from a CO2  vasodilatory stimulus, often using the breath-holding index (BHI). In this method, transcranial Doppler (TCD) ultrasound is used to measure CBFV changes in the middle cerebral artery (MCA) during a breath-hold maneuver. Despite its convenience, BHI has high variability. Changing body position may contribute to potential variability...
March 22, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29565505/changes-in-cerebrovascular-reactivity-in-healthy-adults-after-acute-exposure-to-high-altitude
#19
J Liu, S-K Zhang, J-M Luo, Q-Z Hu, W-Y Ma, S-Z Wu
OBJECTIVE:   To study changes in the cerebrovascular reactivity (CVR) at different altitude area in healthy adults. SUBJECTS AND METHODS: CVR was tested using transcranial Doppler combined with CO2 inhalation, near-infrared spectroscopy (NIRS) was used to detect the regional cerebral oxygen saturation (rScO2). Blood samples were collected, and the vasoactive substances in serum were detected using the enzyme-linked immunosorbent assay. In this study, 59 healthy adults were divided into 3 groups: low altitude group, medium altitude group and high altitude group...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29563868/glycerophospholipid-supplementation-as-a-potential-intervention-for-supporting-cerebral-structure-in-older-adults
#20
Jeffery M Reddan, David J White, Helen Macpherson, Andrew Scholey, Andrew Pipingas
Modifying nutritional intake through supplementation may be efficacious for altering the trajectory of cerebral structural decline evident with increasing age. To date, there have been a number of clinical trials in older adults whereby chronic supplementation with B vitamins, omega-3 fatty acids, or resveratrol, has been observed to either slow the rate of decline or repair cerebral tissue. There is also some evidence from animal studies indicating that supplementation with glycerophospholipids (GPL) may benefit cerebral structure, though these effects have not yet been investigated in adult humans...
2018: Frontiers in Aging Neuroscience
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