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Brain arteriovenous malformation

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https://www.readbyqxmd.com/read/29772363/a-comprehensive-study-of-symptomatic-late-radiation-induced-complications-after-radiosurgery-for-brain-arteriovenous-malformation-incidence-risk-factors-and-clinical-outcomes
#1
Hirotaka Hasegawa, Shunya Hanakita, Masahiro Shin, Takehiro Sugiyama, Mariko Kawashima, Wataru Takahashi, Masaaki Shojima, Osamu Ishikawa, Hirofumi Nakatomi, Nobuhito Saito
OBJECT: Stereotactic radiosurgery (SRS) is widely used to treat brain arteriovenous malformation (AVM); however, detailed information on late radiation-induced complications (LRICs) is scarce. The goal of the present study was to characterize the incidence, risk factors, and clinical outcomes of LRICs based on our long-term follow-up data. METHODS: The outcomes of consecutive patients who underwent SRS for AVMs at our institution in 1990-2010 were analyzed. Cyst formation/encapsulated hematoma (CF/EH) and radiation-induced tumor (RIT) were defined as LRICs...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29762746/microsurgery-versus-stereotactic-radiosurgery-for-brain-arteriovenous-malformations-a-matched-cohort-study
#2
Ching-Jen Chen, Dale Ding, Tony R Wang, Thomas J Buell, Adeel Ilyas, Natasha Ironside, Cheng-Chia Lee, M Yashar Kalani, Min S Park, Kenneth C Liu, Jason P Sheehan
BACKGROUND: Microsurgery (MS) and stereotactic radiosurgery (SRS) remain the preferred interventions for the curative treatment of brain arteriovenous malformations (AVM), but their relative efficacy remains incompletely defined. OBJECTIVE: To compare the outcomes of MS to SRS for AVMs through a retrospective, matched cohort study. METHODS: We evaluated institutional databases of AVM patients who underwent MS and SRS. MS-treated patients were matched, in a 1:1 ratio based on patient and AVM characteristics, to SRS-treated patients...
May 12, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29755904/radiation-induced-cavernous-malformation-as-a-late-sequelae-of-stereotactic-radiosurgery-for-epilepsy
#3
Ethan A Winkler, Caleb Rutledge, Mariann Ward, Tarik Tihan, Patricia K Sneed, Nicholas Barbaro, Paul Garcia, Michael McDermott, Edward F Chang
Stereotactic radiosurgery (SRS) is a promising treatment for medically intractable mesial temporal lobe epilepsy. SRS for epilepsy has had an acceptable safety profile with reports of radiation-induced vascular malformations confined to central nervous system pathologies with prominent angiogenesis - namely, primary brain tumors, metastases, and arteriovenous malformations. Theoretical risks for radiation-induced lesions following radiosurgery for epilepsy have yet to be established. Of 13 patients treated in a pilot trial for medial temporal lobe epilepsy, one developed multiple delayed radiation-induced cavernous malformations following radiosurgery...
March 11, 2018: Curēus
https://www.readbyqxmd.com/read/29753079/curative-transvenous-embolization-for-ruptured-brain-arteriovenous-malformations-a-single-center-experience-from-china
#4
Yingkun He, Weixing Bai, Tianxiao Li, Ferdinand K Hui, Yanyan He, Bin Xu
OBJECTIVE: To evaluate the feasibility and safety of transvenous embolization treatment for brain arteriovenous malformations (bAVM). METHODS: Between November 2016 and August 2017, a transvenous endovascular embolization protocol was implemented at the Henan Provincial People's Hospital for consecutive patients with ruptured bAVM. Therapeutic decision making was based on Spetzler-Martin grades, bAVM location, pattern of venous drainage, and angioarchitecture. And the transvenous embolization procedure was combined with transarterial support...
May 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29752992/radiosurgery-reduces-plasma-levels-of-angiogenic-factors-in-brain-arteriovenous-malformation-patients
#5
Ming Xu, Xiaoxia Liu, Guanghai Mei, Junjie Zhang, Weixing Wang, Hongzhi Xu
PURPOSE: Aberrant expression of angiogenic factors has been anecdotally documented in brain arteriovenous malformation (AVM) nidus vessels; however, no data is available on the effect of radiosurgery on the levels of angiogenic factors in AVM patients. We sought to determine the plasma contents of VEGF, TGF-β, Ang-2 and bFGF in 28 brain AVM patients at baseline and post radiosurgery and further analyzed the relationship between plasma contents of these angiogenic factors with clinicopathologic variables of these patients...
May 9, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29751183/onyx-embolization-before-the-surgical-treatment-of-grade-iii-spetzler-martin-brain-arteriovenous-malformations-single-center-experience-and-technical-nuances
#6
S Luzzi, M Del Maestro, D Bongetta, C Zoia, A V Giordano, D Trovarelli, Dehcordi S Raysi, R J Galzio
BACKGROUND: grade-III Spetzler-Martin (SM) brain arteriovenous malformations (AVMs) are a specific set of AVMs with a high variability in terms of site, size, angioarchitecture, flow dynamics and involvement of eloquent areas. Surgery preceded by pre-operative embolization has been reported as a useful treatment option for these lesions. The aim of this study is to report outcomes and personal experience of combined pre-operative Onyx embolization and surgical resection on a consecutive series of grade-III brain AVMs...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29733392/the-application-of-the-novel-grading-scale-lawton-young-grading-system-to-predict-the-outcome-of-brain-arteriovenous-malformation
#7
Ahmad Hafez, Päivi Koroknay-Pál, Elias Oulasvirta, Ahmed Abou Elseoud, Michael T Lawton, Mika Niemelä, Aki Laakso
BACKGROUND: A supplementary grading scale (Supplemented Spetzler-Martin grade, Supp-SM) was introduced in 2010 as a refinement of the SM system to improve preoperative risk prediction of brain arteriovenous malformations (AVMs). OBJECTIVE: To determine the ability to predict surgical outcomes using the Supp-SM grading scale. METHODS: This retrospective study was conducted on 200 patients admitted to the Helsinki University Hospital between 2000 and 2014...
May 4, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29728873/modern-radiosurgical-and-endovascular-classification-schemes-for-brain-arteriovenous-malformations
#8
REVIEW
Ali Tayebi Meybodi, Michael T Lawton
Stereotactic radiosurgery (SRS) and endovascular techniques are commonly used for treating brain arteriovenous malformations (bAVMs). They are usually used as ancillary techniques to microsurgery but may also be used as solitary treatment options. Careful patient selection requires a clear estimate of the treatment efficacy and complication rates for the individual patient. As such, classification schemes are an essential part of patient selection paradigm for each treatment modality. While the Spetzler-Martin grading system and its subsequent modifications are commonly used for microsurgical outcome prediction for bAVMs, the same system(s) may not be easily applicable to SRS and endovascular therapy...
May 4, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29719554/pipeline-flex-embolization-of-flow-related-aneurysms-associated-with-arteriovenous-malformations-a-case-report
#9
Narlin B Beaty, Jessica K Campos, Geoffrey P Colby, Li-Mei Lin, Matthew T Bender, Risheng Xu, Alexander L Coon
Background: An estimated 0.1% of the population harbors brain arteriovenous malformations (AVMs). Diagnosis and workup of AVMs include thorough evaluation for characterization of AVM angioarchitecture and careful assessment for concomitant aneurysms. The presence of coexisting aneurysms is associated with an increased risk of intracranial hemorrhage, with a published risk of 7% per year compared to patients with AVMs alone with a risk of 3%. Comprehensive AVM management requires recognition of concomitant aneurysms and prioritizes treatment strategies to mitigate the aggregate risk of intracranial hemorrhage associated with AVM rupture in patients with coexisting aneurysms...
April 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29718446/letter-results-of-surgery-for-low-grade-brain-arteriovenous-malformation-resection-by-early-career-neurosurgeons-an-observational-study
#10
Justin R Mascitelli, Michael T Lawton
No abstract text is available yet for this article.
April 27, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29718388/the-use-of-hypofractionated-radiosurgery-for-the-treatment-of-intracranial-lesions-unsuitable-for-single-fraction-radiosurgery
#11
Jim Zhong, Robert H Press, Jeffrey J Olson, Nelson M Oyesiku, Hui-Kuo G Shu, Bree R Eaton
Stereotactic radiosurgery (SRS) is commonly used in the treatment of brain metastases, benign tumors, and arteriovenous malformations (AVM). Single-fraction radiosurgery, though ubiquitous, is limited by lesion size and location. In these cases, hypofractionated radiosurgery (hfSRS) offers comparable efficacy and toxicity. We review the recent literature concerning hfSRS in the treatment of brain metastases, benign tumors, and AVMs that are poorly suited for single-fraction SRS. Published retrospective analyses suggest that local control rates for brain metastases and benign tumors, as well as the rates of AVM obliteration, following hfSRS treatment are comparable to those reported for single-fraction SRS...
April 28, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29696173/safety-and-efficacy-of-endovascular-therapy-and-gamma-knife-surgery-for-brain-arteriovenous-malformations-in-china-study-protocol-for-an-observational-clinical-trial
#12
Hengwei Jin, Xiaochuan Huo, Yuhua Jiang, Xiaolong Li, Youxiang Li
Introduction: Brain arteriovenous malformations (BAVMs) are associated with high morbidity and mortality. The treatment of BAVM remains controversial. Microinvasive treatment, including endovascular therapy and gamma knife surgery, has been the first choice in many conditions. However, the overall clinical outcome of microinvasive treatment remains unknown and a prospective trial is needed. Methods: This is a prospective, non-randomized, and multicenter observational registry clinical trial to evaluate the safety and efficacy of microinvasive treatment for BAVMs...
September 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29689389/deep-sequencing-of-small-rnas-in-blood-of-patients-with-brain-arteriovenous-malformations
#13
Yong Chen, Zhili Li, Yi Shi, Guangfu Huang, Longyi Chen, Haibin Tan, Zhenyu Wang, Cheng Yin, Junting Hu
BACKGROUND: The deregulation of circulating microRNAs (miRNAs) is always associated with development and progression of human diseases. We are aimed to assess whether brain arteriovenous malformations (BAVMs) patients present a distinct miRNA signature compared with healthy subjects. METHODS: Three unruptured BAVMs patients and three normal controls were recruited as case and normal groups. Peripheral blood was collected and miRNA signature was obtained by next-generation sequencing, followed by comparative, functional, and network analyses...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29660051/resection-of-right-frontal-arteriovenous-malformation-3-dimensional-operative-video
#14
William T Couldwell
The video demonstrates resection of a Grade II Spetzler-Martin unruptured, medium-sized arteriovenous malformation (AVM). A young woman presented with headaches and seizures. The right frontal lesion measured 4.5 cm in largest dimension and had superficial venous drainage. Partial Onyx embolization, primarily of the anterior cerebral feeding arteries, was performed. Bone removal for exposure allowed identification of indentation from the large superficial draining vein. The video demonstrates careful microsurgical dissection on the AVM/brain interface, with selective interruption of feeding arteries circumferentially...
April 11, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29628339/ischemic-stroke-secondary-to-paradoxical-embolism-through-a-pulmonary-arteriovenous-malformation-case-report-and-review-of-the-literature
#15
Ryan Cappa, Jeanette Du, Joseph F Carrera, Jimmy V Berthaud, Andrew M Southerland
Paradoxical embolism due to isolated pulmonary arteriovenous malformation (AVM) is an uncommon cause of ischemic stroke, with the majority occurring in patients who have not yet been diagnosed with their malformation. We report a 32-year-old man who presented with an abrupt onset of right facial weakness and expressive aphasia. Brain magnetic resonance imaging revealed an acute infarct in the left middle cerebral artery territory and chronic infarcts in the bilateral cerebellar hemispheres. A cardioembolic mechanism was initially considered in the setting of perimyocarditis diagnosed a few months earlier...
April 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29622371/a-reanalysis-of-predictors-for-the-risk-of-hemorrhage-in-brain-arteriovenous-malformation
#16
Zheng Huang, Kang Peng, Changqing Chen, Feiyue Zeng, Junyu Wang, Fenghua Chen
BACKGROUND: Brain arteriovenous malformation (BAVM) is a congenital cerebral vascular disease that characterized with intracranial hemorrhage and epilepsy. It has some risk in current treatments including microsurgery, endovascular, and radiation therapy. Some patients with bAVMs may keep unruptured in their whole life. Whether it should be treated depends on the evaluation of the hemorrhage risk of bAVM. Although previous studies gave many significant predictors, we tried to find some new and more significant predictors in 173 patients with bAVMS by retrospective analysis...
April 2, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29618868/alveolar-soft-part-sarcoma-of-the-forearm
#17
B Asokan, P Ramanan, M Sundararaj, E Kovarthini
Alveolar soft part sarcoma (ASPS) is a rare form of soft-tissue sarcoma arising from connective tissue. It is most often seen in adolescents and young adults and has high propensity for recurrence and metastasis. Clinically, it mimics haemangioma or arteriovenous malformations. In our case report, an 18-year-old female presented with markedly vascular tumour in the left forearm, for which excision biopsy was done. Histopathological report revealed ASPS. The patient was screened for metastasis. Ultrasound abdomen, computed tomography (CT) chest, CT brain and whole-body skeletal survey was done...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29614355/a-rare-case-of-brain-angiolipoma-imitating-arteriovenous-malformation-differential-diagnosis-surgical-treatment-and-literature-review
#18
Oleg Shekhtman, Vadim Gorozhanin, Lyudmila Shishkina
No abstract text is available yet for this article.
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29608734/results-of-surgery-for-low-grade-brain-arteriovenous-malformation-resection-by-early-career-neurosurgeons-an-observational-study
#19
Nirav J Patel, David Bervini, Behzad Eftekhar, Andrew Stewart Davidson, Daniel C Walsh, Nazih N Assaad, Michael Kerin Morgan
BACKGROUND: For sustainability of arteriovenous malformation (AVM) surgery, results from early career cerebrovascular neurosurgeons (ECCNs) must be acceptably safe. OBJECTIVE: To determine whether ECCNs performance of Spetzler-Ponce Class A AVM (SPC A) resection can be acceptably safe. METHODS: ECCNs completing a cerebrovascular fellowship (2004-2015) with the last author were included. Inclusion of the ECCN cases occurred if they: had a prospective database of all AVM cases since commencing independent practice; were the primary surgeon on SPC A; and had made the significant management decisions...
March 28, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29604508/conventional-digital-subtractional-vs-non-invasive-mr-angiography-in-the-assessment-of-brain-arteriovenous-malformation
#20
Nguyen Ngoc Cuong, Vu Dang Luu, Tran Anh Tuan, Le Tuan Linh, Kieu Dinh Hung, Vo Truong Nhu Ngoc, Kulbhushan Sharma, Van Huy Pham, Dinh-Toi Chu
OBJECTIVES: Digital subtractional angiography (DSA) is the standard method for diagnosis, assessment and management of arteriovenous malformation in the brain. Conventional DSA (cDSA) is an invasive imaging modality that is often indicated before interventional treatments (embolization, open surgery, gamma knife). Here, we aimed to compare this technique with a non-invasive MR angiography (MRI DSA) for brain arteriovenous malformation (bAVM). PATIENTS AND METHODS: Fourteen patients with ruptured brain AVM underwent embolization treatment pre-operation...
March 27, 2018: Clinical Neurology and Neurosurgery
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