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Brain arteriovenous malformation

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https://www.readbyqxmd.com/read/28522939/identification-of-protein-targets-in-cerebral-endothelial-cells-for-brain-arteriovenous-malformation-avms-molecular-therapies
#1
Margaret Simonian, Rachel R Ogorzalek Loo, Nalaka Rannulu, Joseph A Loo, Mark P Molloy, Marcus A Stoodley
BACKGROUND: To develop a new molecular targeted treatment for brain (AVMs), identification of membrane proteins that are localised on the AVM endothelium is crucial. Current treatment methods are surgery and radiosurgery. However, complete occlusion post radiosurgery are achieved within 3 years, while patient remain at risk of haemorrhage. This study aims to identify potential protein targets in AVM endothelial cells that discriminate these vessels from normal vessels; these proteins targets will be investigated for the molecular therapy of brain AVMs to promote rapid thrombosis after radiosurgery...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28521439/arteriovenous-malformation-and-thyroid-metastasis-from-underlying-renal-cell-carcinoma-an-unusual-presentation-of-malignancy-a-case-report
#2
H J Albandar, E S Roberto, J R H See, J H Sabiers
Renal Clear Cell Carcinoma (RCC) comprises over 80% of renal malignancies in adults. Thyroid gland metastasis is rare in RCC. Few studies have described cases of RCC mistaken for benign arteriovenous malformation (AVM). To the best of our knowledge, an AVM arising from underlying RCC metastasis to the brain has not yet been reported. The current study presents a case of RCC metastasis to the thyroid gland, with an AVM identified to be a result of metastatic involvement in the brain. A 45-year-old African-American female presented with left-sided weakness, slurred speech, facial droop and seizure...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28502562/grade-1-spetzler-and-martin-cerebral-ruptured-arteriovenous-malformations-treated-by-microsurgery-poor-functional-outcome-is-related-to-injury-from-haemorrhage
#3
R Aboukaïs, M Quidet, M Baroncini, P Bourgeois, X Leclerc, M Vinchon, J-P Lejeune
INTRODUCTION: Ruptured arteriovenous malformations (rAVM) are life-threatening diseases. OBJECTIVE: To evaluate the outcome of patients with grade 1 SPM rAVM after microsurgical treatment. MATERIALS AND METHOD: We retrospectively included 64 consecutive operated patients with a grade 1 SPM rAVM in our institution between 2002 and 2012. Complications related to the surgical procedure were recorded. All patients were re-evaluated 3months after treatment using the modified Rankin Scale score (mRS)...
May 11, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28498057/stereotactic-radiosurgery-alone-or-combined-with-embolization-for-brain-arteriovenous-malformations-a-systematic-review-and-meta-analysis
#4
Dylan Russell, Travis Peck, Dale Ding, Ching-Jen Chen, Davis G Taylor, Robert M Starke, Cheng-Chia Lee, Jason P Sheehan
OBJECTIVE Embolization of brain arteriovenous malformations (AVMs) prior to stereotactic radiosurgery (SRS) has been reported to negatively affect obliteration rates. The goal of this systematic review and meta-analysis was to compare the outcomes of AVMs treated with embolization plus SRS (E+SRS group) and those of AVMs treated with SRS alone (SRS group). METHODS A literature review was performed using PubMed to identify studies with 10 or more AVM patients and obliteration data for both E+SRS and SRS groups...
May 12, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28489992/arteriovenous-malformations-of-the-brain
#5
Robert A Solomon, E Sander Connolly
New England Journal of Medicine, Volume 376, Issue 19, Page 1859-1866, May 2017.
May 11, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28487334/hemorrhage-risk-of-brain-arteriovenous-malformations-during-pregnancy-and-puerperium-in-a-north-american-cohort
#6
Jose L Porras, Wuyang Yang, Eunice Philadelphia, Jody Law, Tomas Garzon-Muvdi, Justin M Caplan, Geoffrey P Colby, Alexander L Coon, Rafael J Tamargo, Judy Huang
BACKGROUND AND PURPOSE: Conclusions reached in existing literature about risk of arteriovenous malformation (AVM) hemorrhage during pregnancy are controversial. This study compares the risk of hemorrhage in pregnant and nonpregnant female patients with AVM in a North American cohort. METHODS: We retrospectively reviewed female patients with AVM evaluated from 1990 to 2015. Exposure period for pregnancy and puerperium was calculated as 40 and 6 weeks, respectively, for each full-term pregnancy and 6 weeks for each abortion...
May 9, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28486221/evaluation-of-clinical-application-and-dosimetric-comparison-of-treatment-plans-of-gamma-knife-and-cyberknife-in-treating-arteriovenous-malformations
#7
Chun-Yuan Kuo, Yi-Chieh Tsai, An-Cheng Shiau, Hao-Wen Cheng, Hsiao-Wei Yu, Yu-Kai Su, Jo-Ting Tsai
PURPOSE: To analyze and compare the characteristics of dose distributions for Leksell Gamma Knife Perfexion (LGK-PFX) and CyberKnife (CK) in treating arteriovenous malformations (AVMs). SUBJECTS AND METHODS: Twenty-four patients with AVMs who received CK radiosurgery at a prescribed dose (PD) of 16-25 Gy in a single fraction were selected. A LGK-PFX treatment plan with the same PD was designed for each patient. Dosimetric values for both systems were compared with respect to the conformity index (CI); selectivity index (SI); gradient index (GI) of 75, 50, and 25% of the PD; heterogeneity index; volume of the brain tissue covered by doses of 10 and 12 Gy; maximum dose delivered to the brainstem; and beam-on time...
May 10, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28484529/secondary-communicating-hydrocephalus-management-by-implantation-of-external-ventricular-shunt-and-minimal-gradual-increase-of-cerebrospinal-fluid-pressure
#8
Keyvan Mostofi, Madjid Samii
BACKGROUND: This paper presents a new management strategy explaining the process used by implantation of external ventricular drainage (EVD) and very gradual increase of intracranial pressure for treatment of acute hydrocephalus. During the last 30 years' experience in professional practice, the senior author (M.S.) discovered that there are some options of regulations between cerebral spinal fluid (CSF) production and resorption. This theory shows that minimal continuous increase of the CSF pressure as long as the patient general neurological condition is unchanged and appears as normal can lead to definitive treatment of hydrocephalus without needing to set a shunt...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28484523/radiosurgery-in-treatment-of-cerebral-arteriovenous-malformation-mid-term-results-of-388-cases-from-a-single-center
#9
Mohammad Ali Bitaraf, Ramon Katoozpour, Mazyar Azar, Mohsen Nouri, Seyed Abolghasem Mortazavi, Abbas Amirjamshidi
BACKGROUND AND OBJECTIVES: The purpose of this study is to evaluate the outcome and risks of radiosurgery for patients with arteriovenous malformations (AVM) of the brain all treated in a single center in the 3(rd) world with all its limitations. MATERIALS AND METHODS: We performed a retrospective analysis of 388 patients with AVM treated with radiosurgery during an 8-year period. Factors associated with increased chance of AVM obliteration or hemorrhages during the follow-up period were analyzed...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28481989/left-atrioventricular-valve-replacement-in-a-patient-with-hereditary-haemorrhagic-telangiectasia
#10
Yasunori Iida, Naritaka Kimura, Akinori Hirano, Hideyuki Shimizu
Hereditary haemorrhagic telangiectasia, or Osler-Rendu-Weber disease, is characterized by multiple arteriovenous malformations and telangiectasia which develop in the brain, lungs or liver. We report the case of a patient who had severe left atrioventricular valve regurgitation with atrial fibrillation after atrioventricular septal defect repair in her childhood and was diagnosed as having hereditary haemorrhagic telangiectasia by chance. The patient underwent successful left atrioventricular valve replacement and maze operation...
May 6, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28465402/a-systematic-characterization-of-the-factors-influencing-polymerization-and-dynamic-behavior-of-n-butyl-cyanoacrylate
#11
Bill H Wang, Melfort Boulton, Donald H Lee, David M Pelz, Stephen P Lownie
INTRODUCTION: Brain arteriovenous malformations are abnormal connections between arteries and veins without an intervening capillary bed. Endovascular glue embolization with N-butyl cyanoacrylate (NBCA) is an accepted form of treatment. The reported complication rates vary widely from 2% to 15%, and timing of polymerization appears to play a major role. Additionally, the interaction between NBCA and vessel surface as well as the presence of biological catalysts are poorly understood. METHODS: Polymerization time was measured for mixtures of Lipiodol/NBCA of 50/50, 70/30, and 60/40...
May 2, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28461276/brain-arteriovenous-malformations-supplied-by-the-anterior-choroidal-artery-treatment-outcomes-and-risk-factors-for-worsened-muscle-strength-after-surgical-resection
#12
Yuming Jiao, Fuxin Lin, Jun Wu, Hao Li, Xin Chen, Zhicen Li, Ji Ma, Yong Cao, Shuo Wang, Jizong Zhao
OBJECT: The treatment of brain arteriovenous malformations (BAVMs) supplied by the anterior choroidal artery (AChA) (aBAVMs) remains challenging. The aim of this study was to determine the surgical outcomes and risk factors for worsened muscle strength (MS) after surgery in patients with aBAVMs. METHODS: We retrospectively reviewed 266 consecutive patients with BAVMs who underwent microsurgical resection of their BAVMs between September 2012 and June 2016. Patients were included if the BAVMs were totally or partially supplied by AChA...
April 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28458385/recent-trends-in-neuro-endovascular-treatment-for-acute-ischemic-stroke-cerebral-aneurysms-carotid-stenosis-and-brain-arteriovenous-malformations
#13
Yuji Matsumaru, Eiichi Ishikawa, Tetsuya Yamamoto, Akira Matsumura
The efficacy of mechanical thrombectomy with stent retrievers for emergent large vessel occlusion has been proved by randomized trials. Mechanical thrombectomy is increasingly being adopted in Japan since stent retrievers were first approved in 2014. An urgent clinical task is to offer structured systems of care to provide this treatment in a timely fashion to all patients with emergent large vessel occlusion. Treatment with flow-diverting stents is currently a preferred treatment option worldwide for large and giant unruptured aneurysms...
May 1, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28454721/the-treatment-of-brain-arteriovenous-malformation-study-tobas-a-preliminary-inter-and-intra-rater-agreement-study-on-patient-management
#14
Robert Fahed, André L Batista, Tim E Darsaut, Jean-Christophe Gentric, Célina Ducroux, Chiraz Chaalala, David Roberge, Michel W Bojanowski, Alain Weill, Daniel Roy, Elsa Magro, Jean Raymond
OBJECT: The best management of brain arteriovenous malformation (bAVM) patients remains unknown. Randomized allocation may be more readily accepted when there is uncertainty and disagreement regarding the management of potential participants. In planning for a trial, we aimed to assess variability and agreement among physicians managing bAVM patients. METHODS: A portfolio composed of 35 patients was sent to 47 clinicians of various specialties managing bAVM patients...
April 25, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28431024/radiosurgery-for-unruptured-brain-arteriovenous-malformations-an-international-multicenter-retrospective-cohort-study
#15
Dale Ding, Robert M Starke, Hideyuki Kano, John Y K Lee, David Mathieu, John Pierce, Paul Huang, Symeon Missios, Caleb Feliciano, Rafael Rodriguez-Mercado, Luis Almodovar, Inga S Grills, Danilo Silva, Mahmoud Abbassy, Douglas Kondziolka, Gene H Barnett, L Dade Lunsford, Jason P Sheehan
BACKGROUND: The role of intervention in the management of unruptured brain arteriovenous malformations (AVM) is controversial. OBJECTIVE: To analyze in a multicenter, retrospective cohort study, the outcomes following radiosurgery for unruptured AVMs and determine predictive factors. METHODS: We evaluated and pooled AVM radiosurgery data from 8 institutions participating in the International Gamma Knife Research Foundation. Patients with unruptured AVMs and ≥12 mo of follow-up were included in the study cohort...
June 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28427848/early-outcomes-and-periprocedural-complications-of-transarterial-embolization-of-brain-arteriovenous-malformations-with-onyx-%C3%A2
#16
Wojciech Poncyljusz, Marcin Sawicki, Katarzyna Lubkowska, Monika Rać
BACKGROUND: Brain arteriovenous malformation (BAVM) is a rare pathology diagnosed mostly in young adults. However, due to its hemorrhagic complications, it constitutes an important clinical problem. Treatment modalities available include endovascular, surgery and radiosurgery. The aim of the study was to assess the efficacy and safety of endovascular treatment of BAVM with Onyx(®) by reporting one-center experience. MATERIAL AND METHODS: Between 2006 and 2013, 54 patients with BAVM were embolized with Onyx...
April 5, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28421824/thrombosis-of-the-draining-vein-causes-intracranial-haemorrhage-in-the-natural-history-of-brain-arteriovenous-malformation-case-report
#17
Raita Fukaya, Katsuhiro Mizutani, Masahito Fukuchi, Koji Fujii
Rupture of arteriovenous malformations (AVM) may be caused by venous outflow restriction, but there is no radiographic evidence of this. We report a case showing only a venous thrombus preceding intracranial haemorrhage from AVM. This is the first evidence that venous thrombus results in AVM rupture in its natural history.
April 19, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28419337/targeted-embolization-of-aneurysms-associated-with-brain-arteriovenous-malformations-at-high-risk-for-surgical-resection-a-case-control-study
#18
Matthew D Alexander, Daniel S Hippe, Daniel L Cooke, Danial K Hallam, Steven W Hetts, Helen Kim, Michael T Lawton, Laligam N Sekhar, Louis J Kim, Basavaraj V Ghodke
BACKGROUND: High-risk components of brain arteriovenous malformations (BAVMs) can be targeted to reduce the risk of lesion rupture. OBJECTIVE: To evaluate targeted embolization of aneurysms against other means of treatment with a case-control analysis; we previously investigated this approach associated with BAVMs. METHODS: Retrospective analysis of patients with BAVMs was performed, identifying patients treated with intention to occlude only an aneurysm associated with a BAVM...
April 13, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28414573/phosphatidylserine-translocation-after-radiosurgery-in-an-animal-model-of-arteriovenous-malformation
#19
Newsha Raoufi Rad, Lucinda S McRobb, Zhenjun Zhao, Vivienne S Lee, Nirav J Patel, Anas Sarwar Qureshi, Michael Grace, Joshua J McHattan, Jude V Amal Raj, Hong Duong, Saleh R Kashba, Marcus A Stoodley
Phosphatidylserine (PS) is asymmetrically distributed across the plasma membrane, located predominantly on the inner leaflet in healthy cells. Translocation of PS to the outer leaflet makes it available as a target for biological therapies. We examined PS translocation after radiosurgery in an animal model of brain arteriovenous malformation (AVM). An arteriovenous fistula was created by end-to-side anastomosis of the left external jugular vein to the common carotid artery in 6-week-old, male Sprague Dawley rats...
April 17, 2017: Radiation Research
https://www.readbyqxmd.com/read/28397378/basal-subarachnoid-hemorrhage-by-rupture-of-arteriovenous-malformation-at-the-cerebellopontine-angle
#20
Mio Takayama, Masayuki Kashiwagi, Kenji Hara, Aya Matsusue, Brian Waters, Natsuki Ikematsu, Shin-Ichi Kubo
A man in his late forties had lived as a recluse for more than ten years. He was found dead in his room. At autopsy, subarachnoid hemorrhage (SAH) was detected at the base of the brain, which weighed 1333 g. The cerebellar tonsil was swollen. The cerebral ventricle was enlarged and filled with blood. A hematoma was observed in the upper part of the left side of the cerebellar hemisphere. The location and size of SAH in this case indicated that the rupture of a cerebral aneurysm (CA) had occurred; however, CA was not detected...
April 10, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
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