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Brain arteriovenous malformation

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https://www.readbyqxmd.com/read/28810087/multiple-pulmonary-arteriovenous-malformations-an-unusual-cause-of-shortness-of-breath-and-recurrent-strokes
#1
Kalyan C Potu, Shenjing Li, Shawn C Kelly, Julia A Prescott-Focht, Scott Pham
OBJECTIVE: To discuss an uncommon case of a patient with multiple pulmonary arteriovenous malformations (PAVMs) presenting with dyspnea on exertion and recurrent strokes. BACKGROUND: A 79-year-old woman with recent onset recurrent cerebrovascular accidents (CVAs) was referred to cardiology for evaluation of dyspnea on exertion. Clinical examination was unrevealing. METHODS: A transthoracic echocardiogram (TTE) with agitated saline was suggestive of an extra-cardiac shunt...
February 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28802071/microrna-137-and-195-inhibit-vasculogenesis-in-brain-arteriovenous-malformations
#2
Jun Huang, Jianping Song, Meijie Qu, Yang Wang, Qinzhu An, Yaying Song, Wei Yan, Bingshun Wang, Xiaojin Wang, Song Zhang, Xi Chen, Bing Zhao, Peixi Liu, Tongyi Xu, Zhijun Zhang, David A Greenberg, Yongting Wang, Pingjin Gao, Wei Zhu, Guo-Yuan Yang
OBJECTIVES: Brain arteriovenous malformations (AVMs) are the most common cause of non-traumatic intracerebral hemorrhage in young adults. The genesis of brain AVM remains enigmatic. We investigated microRNA (miRNA) expression and its contribution to the pathogenesis of brain AVMs. METHODS: We used a large-scale miRNA analysis on 16 samples including AVMs, hemangioblastoma, and controls to identify a distinct AVM miRNA signature. AVM smooth muscle cells (AVMSMCs) were isolated and identified by flow cytometry and immunohistochemistry and candidate miRNAs were then tested in these cells...
August 12, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28796572/endoglin-and-alk1-as-therapeutic-targets-for-hereditary-hemorrhagic-telangiectasia
#3
Lidia Ruiz-Llorente, Eunate Gallardo-Vara, Elisa Rossi, David M Smadja, Luisa M Botella, Carmelo Bernabeu
Hereditary Haemorrhagic Telangiectasia (HHT) is as an autosomal dominant trait characterized by frequent nose bleeds, mucocutaneous telangiectases, arteriovenous malformations (AVMs) of the lung, liver and brain, and gastrointestinal bleedings due to telangiectases. HHT is originated by mutations in genes whose encoded proteins are involved in the transforming growth factor β (TGF-β) family signalling of vascular endothelial cells. In spite of the great advances in the diagnosis as well as in the molecular, cellular and animal models of HHT, the current treatments remain just at the palliative level...
August 10, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28775059/basal-ganglia-t1-hyperintensity-in-hereditary-hemorrhagic-telangiectasia
#4
A Parvinian, V N Iyer, B S Pannu, D R Apala, C P Wood, W Brinjikji
BACKGROUND AND PURPOSE: The implications of basal ganglia T1 hyperintensity remain unclear in patients with hereditary hemorrhagic telangiectasia. This study was performed to assess the prevalence of this imaging finding in a large cohort of patients with hereditary hemorrhagic telangiectasia and to identify any association between this phenomenon and other disease manifestations. MATERIALS AND METHODS: In this retrospective study, we identified all patients at our institution diagnosed with definite hereditary hemorrhagic telangiectasia from 2001 to 2017...
August 3, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28767347/arteriovenous-malformations-of-the-brain
#5
LETTER
Sung-Hye You, Byungjun Kim, Sang W Shin
New England Journal of Medicine, Volume 377, Issue 5, Page 497-498, August 2017.
August 3, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28767346/arteriovenous-malformations-of-the-brain
#6
LETTER
(no author information available yet)
No abstract text is available yet for this article.
August 3, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28764614/quantitative-evaluation-of-arteriovenous-malformation-hemodynamic-changes-after-endovascular-treatment-using-parametric-color-coding-a-case-series-study
#7
Rodrigo Rivera, Juan G Sordo, Daniel Echeverria, Lautaro Badilla, Camila Pinto, Catalina Merino-Osorio
Background Brain arteriovenous malformations (AVMs) are complex vascular lesions. Endovascular treatment results are usually measured by calculating the volume reduction of the lesions. Nevertheless, vascular flow quantification seems a more physiologically accurate way of measuring endovascular results. We evaluated the use of parametric color coding (PCC) with digital subtraction angiography (DSA), in order to determine the feasibility of PCC to detect and measure the impact of AVM endovascular treatment-induced changes using real-time hemodynamic parameters...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28746925/pulmonary-arteriovenous-malformations-are-associated-with-silent-brain-infarcts-in-hereditary-hemorrhagic-telangiectasia-patients
#8
Waleed Brinjikji, Deena M Nasr, Christopher P Wood, Vivek N Iyer
BACKGROUND AND PURPOSE: There is a high prevalence of right-to-left shunting pulmonary arteriovenous malformations (PAVMs), which are stroke risk factors, in hereditary hemorrhagic telangiectasia (HHT) patients. While the prevalence of ischemic complications in HHT patients is known, the prevalence of silent brain infarcts (SBI) remains unknown. The purpose of this study was to determine the prevalence and risk factors for SBI in HHT patients. MATERIALS AND METHODS: Our institutional HHT database was queried to identify HHT patients who received a baseline screening brain MRI from January 2000 to February 2017...
July 27, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28743113/pulmonary-hypertension-in-a-large-cohort-with-hereditary-hemorrhagic-telangiectasia
#9
Veronique Vorselaars, Sebastiaan Velthuis, Marco van Gent, Cornelis Westermann, Repke Snijder, Johannes Mager, Martijn Post
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder characterized by arteriovenous malformations in the brain, liver, and lungs. Pulmonary hypertension (PH) is increasingly recognized as a severe complication of HHT. However, there are no studies describing the prevalence of PH in HHT compared to HHT-negative controls. OBJECTIVE: To assess the estimated prevalence of PH in patients with HHT compared to HHT-negative controls. METHODS: All consecutive subjects screened for HHT with available genetic testing and echocardiography-based peak tricuspid regurgitation velocity (TRV) measurement were included...
July 26, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28740770/versatility-of-the-latissimus-dorsi-free-flap-during-the-treatment-of-complex-postcraniotomy-surgical-site-infections
#10
Nobutaka Yoshioka
BACKGROUND: Some intractable cases of postcraniotomy infection, which can involve compromised skin, an open frontal air sinus, and residual epidural dead space, have been reported. In such cases, reconstructing the scalp and skull is challenging. METHODS: Between 2009 and 2016, the author treated 12 patients with recalcitrant postcraniotomy surgical site infections with latissimus dorsi (LD) free flaps. The patients' ages ranged from 37 to 79 years (mean, 63.5 years), and their underlying diseases included subarachnoid hemorrhaging (n = 5), brain tumors (n = 4), and cerebral arteriovenous malformations (n = 3)...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28740448/evaluation-of-brain-edema-formation-defined-by-mri-after-linac-based-stereotactic-radiosurgery
#11
Maciej Harat, Andrzej Lebioda, Judyta Lasota, Roman Makarewicz
BACKGROUND: Peri-lesional edema is a serious and well-known complication of stereotactic radiosurgery (SRS). Here we evaluated edema risk after SRS and assessed its formation and resolution dynamics. PATIENTS AND METHODS: 107 patients underwent SRS for heterogeneous diagnoses: 34 (29%) with arteriovenous malformations, 38 (35%) with meningiomas, 16 (15%) with metastatic tumors, 16 (15%) with acoustic neuromas, 3 with (3%) cavernomas, and 2 (2%) each with anaplastic astrocytomas and anaplastic oligoastrocytomas...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28735125/management-of-arteriovenous-malformations-associated-with-developmental-venous-anomalies-a-literature-review-and-report-of-two-cases
#12
Michael Zhang, Ian D Connolly, Mario K Teo, George Yang, Robert Dodd, Michael Marks, Mario Zuccarello, Gary K Steinberg
OBJECTIVE: Cerebrovascular malformation classification has revealed intermediary lesions that warrant further review due to their unusual presentation and management. We present two cases of arteriovenous malformations (AVMs) associated with a developmental venous anomaly (DVA), and discuss the efficacy of previously published management strategies. METHODS: Two cases of AVMs associated with DVA were identified and a literature search for published cases between 1980 and 2016 was conducted...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28712909/comparison-of-grading-scales-regarding-perioperative-complications-and-clinical-outcomes-of-brain-arteriovenous-malformations-after-endovascular-therapy-a-multicenter-study
#13
Hengwei Jin, Yuhua Jiang, Huijian Ge, Jing Luo, Conghui Li, Hongxing Wu, Youxiang Li
OBJECTIVES: Several scales have been proposed for risk assessment and outcome determination in brain arteriovenous malformations (bAVMs) treated by endovascular therapy. We aim to validate and compare the efficacy of these scales in predicting perioperative complications and clinical outcomes. METHODS: We retrospectively reviewed bAVM patients who underwent endovascular therapy at 4 centers in China from January 2012 to December 2015. The primary outcomes were complications, unfavorable outcome (mRS≥3) and complete obliteration...
July 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28710086/onyx-embolization-prior-to-stereotactic-radiosurgery-for-brain-arteriovenous-malformations-a-single-center-treatment-algorithm
#14
John D Nerva, Jason Barber, Michael R Levitt, Jason K Rockhill, Danial K Hallam, Basavaraj V Ghodke, Laligam N Sekhar, Louis J Kim
BACKGROUND: Embolization before stereotactic radiosurgery (SRS) for brain arteriovenous malformations (BAVMs) is controversial. OBJECTIVE: To compare clinical and radiographic outcomes in patients undergoing pre-SRS embolization with ethylene copolymer (Onyx) with outcomes in patients undergoing SRS alone. METHODS: Seventy consecutive patients with BAVMs who underwent SRS were retrospectively reviewed. Univariate and multivariate analyses were performed to assess the factors associated with radiographic obliteration and complication...
July 14, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28696502/linking-brain-arteriovenous-malformations-with-anorectal-hemorrhoids-a-clinical-and-anatomical-review
#15
REVIEW
Joshua A Cuoco, Christopher L Hoehmann, Kyle Hitscherich, Sherry M Zakhary, Joerg R Leheste, German Torres
Patients who harbor brain arteriovenous malformations are at risk for intracranial hemorrhage. These malformations are often seen in inherited vascular diseases such as hereditary hemorrhagic telangiectasia. However, malformations within the brain also sporadically occur without a hereditary-coding component. Here, we review recent insights into the pathophysiology of arteriovenous malformations, in particular, certain signaling pathways that might underlie endothelial cell pathology. To better interpret the origins, determinants and consequences of brain arteriovenous malformations, we present a clinical case to illustrate the phenotypic landscape of the disease...
July 11, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28691576/time-resolved-computed-tomography-angiography-in-the-evaluation-of-brain-arteriovenous-malformation-a-feasibility-study
#16
Rupinder Singh, Vivek Gupta, Chirag Ahuja, Niranjan Khandelwal
Background and purpose Digital subtraction angiography is the current gold standard for diagnosing as well as the follow-up of cerebral arteriovenous malformations. However, as it is invasive, relatively expensive and time-consuming, a non-invasive alternative is of interest. We aimed to evaluate the feasibility of time resolved computed tomography angiography (TR-CTA) in a series of five diagnosed cranial arteriovenous malformation patients, demonstrated by conventional digital subtraction angiography with respect to acquisition, depiction of angiographic phases and radiation exposure...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28686111/delayed-treatment-of-ruptured-brain-avms-is-it-ok-to-wait
#17
Jeffrey S Beecher, Kristopher Lyon, Vin Shen Ban, Awais Vance, Cameron M McDougall, Louis A Whitworth, Jonathan A White, Duke Samson, H Hunt Batjer, Babu G Welch
OBJECTIVE Despite a hemorrhagic presentation, many patients with arteriovenous malformations (AVMs) do not require emergency resection. The timing of definitive management is not standardized in the cerebrovascular community. This study was designed to evaluate the safety of delaying AVM treatment in clinically stable patients with a new hemorrhagic presentation. The authors examined the rate of rehemorrhage or neurological decline in a cohort of patients with ruptured brain AVMs during a period of time posthemorrhage...
July 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28681759/dose-fractionated-gamma-knife-radiosurgery-for-large-arteriovenous-malformations-on-daily-or-alternate-day-schedule-outside-the-linear-quadratic-model-proof-of-concept-and-early-results-a-substitute-to-volume-fractionation
#18
Kanchan Kumar Mukherjee, Narendra Kumar, Manjul Tripathi, Arun S Oinam, Chirag K Ahuja, Sivashanmugam Dhandapani, Rakesh Kapoor, Sushmita Ghoshal, Rupinder Kaur, Sandeep Bhatt
BACKGROUND: To evaluate the feasibility, safety and efficacy of dose fractionated gamma knife radiosurgery (DFGKRS) on a daily schedule beyond the linear quadratic (LQ) model, for large volume arteriovenous malformations (AVMs). MATERIAL AND METHODS: Between 2012-16, 14 patients of large AVMs (median volume 26.5 cc) unsuitable for surgery or embolization were treated in 2-3 of DFGKRS sessions. The Leksell G frame was kept in situ during the whole procedure. 86% (n = 12) patients had radiologic evidence of bleed, and 43% (n = 6) had presented with a history of seizures...
July 2017: Neurology India
https://www.readbyqxmd.com/read/28681734/fractionated-gamma-knife-radiosurgery-for-large-brain-arteriovenous-malformations
#19
Manmohan Singh
No abstract text is available yet for this article.
July 2017: Neurology India
https://www.readbyqxmd.com/read/28681273/delayed-symptomatic-haemorrhage-from-the-remnants-of-a-thalamic-arteriovenous-malformation-after-previous-angiographic-cure-with-radiotherapy
#20
Paulina Majewska, Alpha Tsui, Alexios A Adamides
In 1995 a 16-year old girl was diagnosed with a large left thalamic AVM that was considered unsuitable for microsurgical resection and was treated with radiotherapy twice, which led to angiographic cure. She re-presented 19 years after initial treatment with a symptomatic acute thalamic haemorrhage. Her digital subtraction angiography was negative for arterio-venous shunting. MRI/MRA showed cystic change with adjacent contrast enhancement in the region of the previously irradiated arteriovenous malformation...
July 5, 2017: Acta Neurochirurgica
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