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https://www.readbyqxmd.com/read/29458231/perioperative-complications-of-transanal-pull-through-surgery-for-hirschsprung-s-disease
#1
Mikko Pakarinen
Transanal pull-through is currently one of the most commonly used operation to treat Hirschsprung's disease (HD) worldwide. It has undergone some technical modifications during the last decades and still contains variable surgical practices. As high quality comparative studies between different surgical approaches are missing, debate over the optimal operation for HD still continues. Transanal pull-through is associated with multiple potential complications, which may result in permanently impaired functional outcome, life-long morbidity, and significant social restrictions...
February 19, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29458223/what-does-antidepressant-drug-level-monitoring-reveal-about-outpatient-treatment-and-patient-adherence
#2
Petr Silhan, Romana Urinovska, Ivana Kacirova, Martin Hyza, Milan Grundmann, Eva Ceskova
INTRODUCTION: The evaluation of plasma levels of antidepressants may improve the treatment outcome. The aim was to verify adherence and adequacy of administered doses of antidepressants among patients hospitalized for inadequate outpatient therapeutic response. METHODS: Selective serotonin reuptake inhibitors or venlafaxine plasma levels were assessed on the first day of hospitalization and after 3 days of controlled administration. The patients were considered adherent if the plasma level on admission was within the interval of the minimum and maximum plasma level on the fourth day, expanded by 30%...
February 19, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29458185/tiny-cerebral-aneurysms-can-be-safely-and-effectively-treated-with-lvis-stent-assisted-coiling-or-coiling-alone
#3
Bu-Lang Gao, Tian-Xiao Li, Li Li, Gang-Qin Xu, Bo-Wen Yang
BACKGROUND: The effect and safety of LVIS stent-coiling is currently not known for treating tiny intracranial aneurysms. OBJECTIVE: To investigate the effect and safety of LVIS stent-assisted coiling and coiling alone in treating patients with mostly ruptured tiny aneurysms. METHODS: Seventy-five patients with tiny intracranial aneurysms including 63 ruptured ones were treated endovascularly and analyzed. RESULTS: In the coiling group, complete occlusion was achieved in 35 patients (83...
February 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29458168/apoptosis-of-enterocytes-and-nitration-of-junctional-complex-proteins-promote-alcohol-induced-gut-leakiness-and-liver-injury
#4
Young-Eun Cho, Li-Rong Yu, Mohamed A Abdelmegeed, Seong-Ho Yoo, Byoung-Joon Song
BACKGROUND & AIMS: Binge alcohol causes gut leakiness, contributing to increased endotoxemia and inflammatory liver injury, although the molecular mechanisms are still elusive. This study was aimed at investigating the roles of apoptosis of enterocytes and nitration followed by degradation of intestinal tight junction (TJ) and adherent junction (AJ) proteins in binge alcohol-induced gut leakiness. METHODS: The levels of intestinal (ileum) junctional complex proteins, oxidative stress markers and apoptosis-related proteins in rodents, T84 colonic cells and autopsied human ileums were determined by immunoblot, immunoprecipitation, immunofluorescence, and mass-spectral analyses...
February 16, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29458091/role-of-the-ssek1-gene-in-the-pathogenicity-of-salmonella-enterica-serovar-enteritidis-in-vitro-and-in-vivo
#5
Yadong Yang, Chuan Yu, Ke Ding, Chunjie Zhang, Chengshui Liao, Yanyan Jia, Jing Li, Xiangchao Cheng
Salmonella enteritidis is a common food-borne pathogen associated with consumption of contaminated poultry meat and eggs, which frequently causes gastroenteritis in humans. Salmonella secreted effector K1 (SseK1), as a translocated and secreted protein has been identified to be essential for the virulence of Salmonella typhimurium in host cells. However, the role of the sseK1 gene in the pathogenicity of S. enteritidis remain unclear. In this study, a sseK1 deletion mutant of S. enteritidis was constructed and its biological characteristics were examined...
February 16, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29457700/impact-of-home-spirometry-on-medication-adherence-among-adolescents-with-cystic-fibrosis
#6
Aarti Shakkottai, Niko Kaciroti, Lauren Kasmikha, Samya Z Nasr
OBJECTIVE: Medication adherence among adolescents with cystic fibrosis (CF) is often suboptimal and this has significant impact on their health and quality of life. The purpose of the study was to evaluate the impact of frequent home pulmonary function (PFT) monitoring on medication adherence among adolescents with CF. HYPOTHESIS: We hypothesized that weekly home PFT monitoring will improve adherence while not significantly adding to the treatment burden. METHODS: Individuals aged 12-21 years with CF were provided a spirometer to measure PFTs weekly for 1 year...
February 19, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29457508/integrative-review-of-mobile-phone-contacts-and-medication-adherence-in-severe-mental-illness
#7
Cordellia E Bright
BACKGROUND: Poor medication adherence is a significant problem in individuals with severe mental illness (SMI). About 50% of people with SMI become nonadherent to treatment in the first month following discharge from the hospital. OBJECTIVE: This study examined literature in the past decade (2006-2016) on the use of mobile phone contacts in individuals with SMI to improve medication adherence post hospital discharge. DESIGN: This integrative review used the search terms texting, text messaging, SMS, cell/mobile phone, medication adherence, medication compliance, and mental illness...
February 1, 2018: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/29457473/going-the-distance-reviewing-antipsychotic-depot-or-long-acting-injectable-treatments-in-australasia
#8
Theo Theodoros, Mark Taylor, Hannah Chu-Han Huang, Nancy Wang, Balaji Motamarri
OBJECTIVES: The aim of this study is to provide an opinion paper reviewing the role of depot or long-acting injectable (LAI) antipsychotic medications, with comments on individual newer LAIs such aripiprazole maintena and paliperidone palmitate. In particular, we share our recent experience of using paliperidone three-monthly LAI. We also reflect on the associated benefits and potential harms of LAIs, and when they may be used. CONCLUSIONS: LAI antipsychotics are an important and arguably under-utilised therapeutic option, particularly where medication adherence is a priority, and where an informed patient opts for this formulation...
February 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29457470/shared-decision-making-in-psychiatry-a-study-of-patient-attitudes
#9
Josie Nott, Aspen Mcintosh, Clare Taube, Mark Taylor
OBJECTIVES: Shared decision-making (SDM) is promoted as beneficial in mental healthcare, despite a dearth of supportive evidence. We aimed to obtain patients' perspective on SDM in a 'real world' hospital sample. METHODS: Structured validated questionnaires were used to examine SDM with regard to treatment choices, and whether SDM influences attitudes towards treatment. The Mini-Mental State Examination was used to assess decision-making capacity. RESULTS: A total of 109 individuals participated, with 60% reporting experiencing SDM...
February 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29457460/stressful-surfaces-cell-metabolism-on-a-poorly-adhesive-substrate
#10
Richard L Surmaitis, Carlos J Arias, Joseph B Schlenoff
The adhesion and proliferation of cells are exquisitely sensitive to the nature of the surface to which they attach. Aside from cell counting, cell "health" on surfaces is typically established by measuring the metabolic rate with dyes that participate in the metabolic pathway or using "live/dead" assays with combinations of membrane permeable/impermeable dyes. The binary information gleaned from these tests-whether cells are attached or not, and whether they are living or dead-provides an incomplete picture of cell health...
February 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29457358/crt-survey-ii-a-european-society-of-cardiology-survey-of-cardiac-resynchronisation-therapy-in-11-088-patients-who-is-doing-what-to-whom-and-how
#11
Kenneth Dickstein, Camilla Normand, Angelo Auricchio, Nigussie Bogale, John G Cleland, Anselm K Gitt, Christoph Stellbrink, Stefan D Anker, Gerasimos Filippatos, Maurizio Gasparini, Gerhard Hindricks, Carina Blomström Lundqvist, Piotr Ponikowski, Frank Ruschitzka, Giovanni Luca Botto, Alan Bulava, Gabor Duray, Carsten Israel, Christophe Leclercq, Peter Margitfalvi, Óscar Cano, Chris Plummer, Nedim Umutay Sarigul, Maciej Sterlinski, Cecilia Linde
BACKGROUND: Cardiac resynchronisation therapy (CRT) reduces morbidity and mortality in appropriately selected patients with heart failure and is strongly recommended for such patients by guidelines. A European Society of Cardiology (ESC) CRT survey conducted in 2008-2009 showed considerable variation in guideline adherence and large individual, national and regional differences in patient selection, implantation practice and follow-up. Accordingly, two ESC associations, the European Heart Rhythm Association and the Heart Failure Association, designed a second prospective survey to describe contemporary clinical practice regarding CRT...
February 19, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29457348/fixed-dose-vs-free-dose-combinations-for-the-management-of-hypertension-an-analysis-of-81-958-patients
#12
Peter Bramlage, Stefanie Schmidt, Helen Sims
Fixed-dose combinations (FDC) have been developed to reduce the pill burden for hypertensive patients. Data on fixed-dose or free-dose (freeDC) ramipril/amlodipine (R/A) or candesartan/amlodipine (C/A) combination treatment initiation were assessed. 71 463 patients were prescribed R/A and 10 495 C/A. For both R/A and C/A, FDC patients were younger (both P < .001) and less comorbid. Prior MI (OR: 0.61 and 0.60), prior stroke (OR: 0.68 and 0.70) and CHD (OR: 0.68 and 0.64) were negatively associated with FDC use, whereas hyperlipidemia was positively associated (OR: 1...
February 19, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29457323/anticoagulation-knowledge-in-patients-with-atrial-fibrillation-an-australian-survey
#13
Kehinde O Obamiro, Leanne Chalmers, Kenneth Lee, Bonnie J Bereznicki, Luke R E Bereznicki
BACKGROUND: Atrial fibrillation (AF) is the most commonly diagnosed arrhythmia in clinical practice, and is associated with a significant medical and economic burden. Anticoagulants reduce the risk of stroke and systemic embolism by approximately two-thirds compared with no therapy. Knowledge regarding anticoagulant therapy can influence treatment outcomes in patients with AF. OBJECTIVE: To measure the level of anticoagulation knowledge in patients with AF taking oral anticoagulants (OACs), investigate the association between patient-related factors and anticoagulation knowledge, and compare these results in patients taking warfarin and direct-acting oral anticoagulant (DOACs)...
February 19, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29457190/family-based-interventions-targeting-improvements-in-health-and-family-outcomes-of-children-and-adolescents-with-type-1-diabetes-a-systematic-review
#14
REVIEW
Marissa A Feldman, Lindsay M Anderson, Jenna B Shapiro, Aneta M Jedraszko, Meredyth Evans, Lindsey E G Weil, Kimberly P Garza, Jill Weissberg-Benchell
PURPOSE OF REVIEW: A systematic review was conducted of family-based interventions to improve glycemic control, adherence, and psychosocial outcomes in children and adolescents with type 1 diabetes (T1D). Electronic databases were searched for randomized controlled trials (RCTs) published since the seminal Diabetes Control and Compliance Trial (DCCT). Interventions are summarized and findings reviewed to help guide clinical practice and future research. RECENT FINDINGS: Twenty-five RCTs are reviewed...
February 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29456621/men-seeking-counselling-in-a-breast-cancer-risk-evaluation-clinic
#15
Ana Catarina Freitas, Ana Opinião, Sofia Fragoso, Hugo Nunes, Madalena Santos, Ana Clara, Sandra Bento, Ana Luis, Jorge Silva, Cecília Moura, Bruno Filipe, Patrícia Machado, Sidónia Santos, Saudade André, Paula Rodrigues, Joana Parreira, Fátima Vaz
Background: Hereditary breast and ovary cancer syndrome affects both genders but little is known about the uptake of genetic services by men. The objective of this study is to characterise the male population counselled through a multidisciplinary breast/ovarian program. Methods: Descriptive analysis of male patients counselled from January 2000 to December 2015. Data in this analysis include new cancer diagnoses during prospective follow up. Results: From 4,320 families registered, 362 male patients were identified: 236 (65...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29456430/effect-of-medical-nutrition-therapy-for-patients-with-type-2-diabetes-in-a-low-no-cost-clinic-a-propensity-score-matched-cohort-study
#16
Mark D Agee, Zane Gates, Patrick M Irwin
Background: Although many studies have been conducted regarding the effectiveness of medical nutrition therapy (MNT) for type 2 diabetes management, less is known about the effectiveness of MNT for low-income adults. This study evaluated the contribution of MNT in improving A1C and blood pressure in a population of low-income adults with type 2 diabetes. Methods: This was a population-based, propensity score-matched cohort study using provincial health data from Altoona, Blair County, Pa...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456425/reasons-for-open-and-closed-attitudes-regarding-type-1-diabetes
#17
Jamie K Easler, Helena M Haueter, Susanne Olsen Roper, Donna Freeborn, Tina Dyches
Thirty-one adults with type 1 diabetes participated in this qualitative study to explore reasons why they were willing (had an open attitude) or unwilling (had a closed attitude) to disclose diabetes-related information to others. Participants (61.3% female, mean age 38.48 years, mean duration of diabetes 21.94 years, 100% white) answered open-ended questions about living with type 1 diabetes. Interviews were transcribed verbatim and coded to identify major patterns that emerged in the data. Reasons for open attitudes included support from others, confidence and feeling comfortable, feeling normal despite diabetes, seeking to educate, and feeling that it was not a major concern to share information with others...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456410/split-dose-bowel-preparation-improves-adequacy-of-bowel-preparation-and-gastroenterologists-adherence-to-national-colorectal-cancer-screening-and-surveillance-guidelines
#18
Stacy Bartnik Menees, H Myra Kim, Philip Schoenfeld
AIM: To quantify the impact of split-dose regimen on endoscopists' compliance with guideline recommendations for timing of repeat colonoscopy in patients with normal colonoscopy or 1-2 small polyps (< 10 mm). METHODS: A retrospective chart review of all endoscopy reports was undertaken in average-risk individuals > 50 years old with a normal screening colonoscopy and 1-2 small polyps. Data were abstracted from two time periods, pre and post-split-dose bowel preparation institution...
February 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29456012/injectable-and-body-temperature-sensitive-hydrogels-based-on-chitosan-and-hyaluronic-acid-for-ph-sensitive-drug-release
#19
Wei Zhang, Xin Jin, Heng Li, Run-Run Zhang, Cheng-Wei Wu
Hydrogels based on chitosan/hyaluronic acid/β-sodium glycerophosphate demonstrate injectability, body temperature sensitivity, pH sensitive drug release and adhesion to cancer cell. The drug (doxorubicin) loaded hydrogel precursor solutions are injectable and turn to hydrogels when the temperature is increased to body temperature. The acidic condition (pH 4.00) can trigger the release of drug and the cancer cell (Hela) can adhere to the surface of the hydrogels, which will be beneficial for tumor site-specific administration of drug...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455932/a-paradigm-shift-on-beta-thalassaemia-treatment-how-will-we-manage-this-old-disease-with-new-therapies
#20
REVIEW
Maria Domenica Cappellini, John B Porter, Vip Viprakasit, Ali T Taher
Beta-thalassaemia causes defective haemoglobin synthesis leading to ineffective erythropoiesis, chronic haemolytic anaemia, and subsequent clinical complications. Blood transfusion and iron chelation allow long-term disease control, and haematopoietic stem cell transplantation offers a potential cure for some patients. Nonetheless, there are still many challenges in the management of beta-thalassaemia. The main treatment option for most patients is supportive care; furthermore, the long-term efficacy and safety of current therapeutic strategies are limited and adherence is suboptimal...
February 12, 2018: Blood Reviews
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