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https://www.readbyqxmd.com/read/28551924/-adherence-to-oral-anti-cancer-drugs-in-hemato-oncology
#1
Sarit Ashkenazi, Juliet Dreyer, Pia Raanani, Avi Leader
Non-adherence to medical treatment is prevalent in the context of potentially life-saving treatment for diseases such as cancer. Estimates of non-adherence to oral anti-cancer therapy range between 27% and 63% in studies of cancer patients. This represents a growing challenge, due to the paradigm shift in anti-cancer treatment from parenteral chemotherapy to oral anti-cancer drugs. The importance of adherence to medical treatment is highlighted by the World Health Organization which considers non-adherence to be a major public health concern...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551861/determinants-of-clinic-absenteeism-a-novel-method-of-examining-distance-from-clinic-and-transportation
#2
Ryan W Dobbs, Neha R Malhotra, Brandon M Caldwell, Raymond Rojas, Daniel M Moreira, Michael R Abern
Delayed treatment and non-adherence are associated with inferior prostate cancer (CaP) outcomes. Missed clinic appointments (MA) are one form of non-adherence that may be preventable. We conducted a retrospective cohort study of 1341 scheduled clinic encounters for men referred to an academic urology clinic for evaluation of known or suspected CaP. Driving distance and public transit times were calculated using a Google Distance Matrix API algorithm. Zip code level data regarding socioeconomic status was obtained from the 2013 American Community Survey...
May 27, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28551762/prophylactic-occlusion-balloon-placement-in-internal-iliac-arteries-for-the-prevention-of-postpartum-haemorrhage-due-to-morbidly-adherent-placenta-short-term-outcomes
#3
Salvatore Alessio Angileri, Leto Mailli, Claudio Raspanti, Anna Maria Ierardi, Gianpaolo Carrafiello, Anna-Maria Belli
PURPOSE: To evaluate outcomes of uterine conserving surgery with occlusion balloon technique. A critical review of the complications was performed. MATERIALS AND METHODS: Between 2010 and 2016, pregnant women, with a prenatal diagnosis of morbidly adherent placenta (MAP), were treated with occlusion balloon catheters in both internal iliac arteries. Parameters such as need for hysterectomy, incidence of PPH, grade of MAP, estimated blood loss during delivery (EBL) and transfusion requirements, mean recovery time and duration of the balloon inflation, were collected and reviewed...
May 27, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28551724/the-rate-of-adherence-to-urate-lowering-therapy-and-associated-factors-in-chinese-gout-patients-a-cross-sectional-study
#4
Rulan Yin, Haixia Cao, Ting Fu, Qiuxiang Zhang, Lijuan Zhang, Liren Li, Zhifeng Gu
The aim of this study was to assess adherence rate and predictors of non-adherence with urate-lowering therapy (ULT) in Chinese gout patients. A cross-sectional study was administered to 125 gout patients using the Compliance Questionnaire on Rheumatology (CQR) for adherence to ULT. Patients were asked to complete the Treatment Satisfaction Questionnaire for Medication version II, Health Assessment Questionnaire, Confidence in Gout Treatment Questionnaire, Gout Knowledge Questionnaire, Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and 36-Item Short Form Health Survey...
May 27, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28551604/abdominoscrotal-hydrocele-in-an-infant-boy
#5
Eliana Costantino, George S Ganesan, J Chadwick Plaire
Abdominoscrotal hydrocele (ASH) is the rarest type of hydrocele. This condition is characterised by a large abdominal and scrotal component connected by an isthmus within the inguinal canal. The incidence among the paediatric population is reported to be less than 3%, although it might be underdiagnosed. Several theories have been proposed in the literature but the aetiology of ASH remains unknown. Diagnosis can be made clinically and confirmed by ultrasound. Spontaneous resolution is rare and long-standing ASH may lead to complications, thus early surgical intervention is recommended...
May 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28551480/general-and-diabetes-specific-stress-in-adolescents-with-type-1-diabetes
#6
Kaitlyn Rechenberg, Robin Whittemore, Margaret Holland, Margaret Grey
BACKGROUND: Type 1 diabetes (T1D) is one of the most common chronic health conditions in adolescents in the United States. Adherence to the recommended treatment regimen has been reported as a source of stress for adolescents. AIM: The purpose of this study was to examine the associations among general and diabetes-specific stress and glycemic control (HbA1c), self-management, and diabetes-specific quality of life (QOL) in adolescents with T1D. METHODS: A secondary analysis of baseline data (N=320) from a randomized controlled trial was conducted...
May 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28551430/exercise-training-improves-physical-function-and-fitness-in-long-term-paediatric-brain-tumour-survivors-treated-with-cranial-irradiation
#7
P J Piscione, E Bouffet, B Timmons, K S Courneya, D Tetzlaff, J E Schneiderman, C B de Medeiros, U Bartels, D J Mabbott
AIMS: We examined the efficacy of exercise training for improving physical functioning and cardiopulmonary fitness in survivors of paediatric brain tumours (BTs) treated with cranial irradiation. METHODS: We conducted a controlled clinical trial with crossover of exercise training versus no training in the community in either a group or combined group/home setting. A volunteer sample of 28 children treated with cranial irradiation for brain tumours completed training (mean age = 11...
May 25, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28551280/evaluation-of-radio-frequency-heating-in-controlling-salmonella-enterica-in-raw-shelled-almonds
#8
Seul-Gi Jeong, Oon-Doo Baik, Dong-Hyun Kang
This study was conducted to investigate the efficacy of radio-frequency (RF) heating to reduce Salmonella enterica serovars Enteritidis, Typhimurium, and Senftenberg in raw shelled almonds compared to conventional convective heating, and the effect of RF heating on quality by measuring changes in the color and degree of lipid oxidation. Agar-grown cells of three pathogens were inoculated onto the surface or inside of raw shelled almonds using surface inoculation or the vacuum perfusion method, respectively, and subjected to RF or conventional heating...
April 19, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28551236/variability-of-traits-and-bioactive-compounds-in-the-fruit-and-pulp-of-six-mamey-apple-mammea-americana-l-accessions
#9
Armelle Péroumal, Sandra Adenet, Katia Rochefort, Louis Fahrasmane, Guylène Aurore
Our objective was to compare fruit morphology, physico-chemistry and bioactive compounds content of the edible pulp of six Mammea americana accessions. The results showed that this fruit was rather big, weighing on average 600 to 1100g depending on the accession, and spherical to oblate-shaped. The pulp represented between 50 and 70% of the weight of the whole fruit. The pulp adhered only partially to the seeds in 5 of the 6 accessions studied, while the last one exhibited full adherence. The fresh pulp was acidic, sweet, succulent and crunchy...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551149/advanced-predictive-methods-for-wine-age-prediction-part-i-a-comparison-study-of-single-block-regression-approaches-based-on-variable-selection-penalized-regression-latent-variables-and-tree-based-ensemble-methods
#10
Ricardo Rendall, Ana Cristina Pereira, Marco S Reis
In this paper we test and compare advanced predictive approaches for estimating wine age in the context of the production of a high quality fortified wine - Madeira Wine. We consider four different data sets, namely, volatile, polyphenols, organic acids and the UV-vis spectra. Each one of these data sets contain chemical information of a different nature and present diverse data structures, namely a different dimensionality, level of collinearity and degree of sparsity. These different aspects may imply the use of different modelling approaches in order to better explore the data set's information content, namely their predictive potential for wine age...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28551100/sialidase-inhibitory-activity-of-diarylnonanoid-and-neolignan-compounds-extracted-from-the-seeds-of-myristica-fragrans
#11
Ji-Young Park, Su Hwan Lim, Bo Ram Kim, Hyung Jae Jeong, Hyung-Jun Kwon, Gyu-Yong Song, Young Bae Ryu, Woo Song Lee
Sialidases are key virulence factors that remove sialic acid from host cell surface glycans, thus unmasking receptors to facilitate bacterial adherence and colonization. In this study, we report the isolation and characterization of novel inhibitors of the Streptococcus pneumoniae sialidases NanA, NanB, and NanC from Myristica fragrans seeds. Of the isolated compounds (1-12), malabaricone C showed the most pneumococcal sialidases inhibition (IC50 of 0.3μM for NanA, 3.6μM for NanB, and 2.9μM for NanC). These results suggested that malabaricone C and neolignans could be potential agents for combating S...
May 18, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28551079/adhesion-attenuates-respiratory-burst-induced-by-different-modes-of-triggering-in-resting-or-lps-primed-neutrophils
#12
Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Urara Tanaka, Rehab Alshargabi, Yoshitomi Aida, Fusanori Nishimura
The effects of adherence on neutrophil superoxide anion (O2(-)) generation triggered by surface, soluble ligand, or adherence were studied. Resting-neutrophils adhered to the uncoated tubes resulting in O2(-) generation, but not on plasma-, fibrinogen-, vitronectin-, fibronectin-, laminin-, collagen-, or poly HEMA-coated surfaces. Enhanced N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated O2(-) generation by LPS-primed-neutrophils was induced by the incubation on plasma, fibrinogen, vitronectin, fibronectin, or laminin in the absence of Mg(2+)...
May 20, 2017: Immunobiology
https://www.readbyqxmd.com/read/28550976/cultivation-and-characterization-of-pterygium-as-an-ex-vivo-study-model-for-disease-and-therapy
#13
Natasha Josifovska, Dóra Júlia Szabó, Richárd Nagymihály, Zoltán Veréb, Andrea Facskó, Ketil Eriksen, Morten C Moe, Goran Petrovski
PURPOSE: Development of ex vivo model to study pathogenesis, inflammation and treatment modalities for pterygium. METHODS: Pterygium obtained from surgery was cultivated (3 months). Gravitational attachment method using viscoelastic facilitated adherence of graft and outgrowing cells. Medium contained serum as the only growth supplement with no use of scaffolds. Surface profiling of the multi-layered cells for hematopoietic- and mesenchymal stem cell markers was performed...
May 24, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28550936/the-bare-necessities-a-realist-review-of-necessity-argumentations-used-in-health-care-coverage-decisions
#14
REVIEW
Tineke Kleinhout-Vliek, Antoinette de Bont, Bert Boer
CONTEXT: Policy makers and insurance companies decide on coverage of care by both calculating (cost-) effectiveness and assessing the necessity of coverage. AIM: To investigate argumentations pertaining to necessity used in coverage decisions made by policy makers and insurance companies, as well as those argumentations used by patients, authors, the public and the media. METHODS: This study is designed as a realist review, adhering to the RAMESES quality standards...
May 5, 2017: Health Policy
https://www.readbyqxmd.com/read/28550908/discordance-between-surgical-care-improvement-project-adherence-and-postoperative-outcomes-implications-for-new-joint-commission-standards
#15
Victor Chang, Robert H Blackwell, Talar Markossian, Ryan M Yau, Barbara A Blanco, Matthew A C Zapf, Gerard J Abood, Gopal N Gupta, Paul C Kuo, Anai N Kothari
BACKGROUND: Infectious (INF) and venous thromboembolism (VTE) complication rates are targeted by surgical care improvement project (SCIP) INF and SCIP VTE measures. We analyzed how adherence to SCIP INF and SCIP VTE affects targeted postoperative outcomes (wound complication [WC], deep vein thrombosis, and pulmonary embolism [PE]) using all-payer data. MATERIALS AND METHODS: A retrospective review (2007-2011) was conducted using Healthcare Cost and Utilization Project State Inpatient Database Florida and Medicare's Hospital Compare...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28550829/-characteristics-associated-with-uncontrolled-blood-pressure-among-portuguese-primary-care-patients-with-type-2-diabetes
#16
Inês Rosendo, Luiz Miguel Santiago, Margarida Marques
INTRODUCTION: Determine whether socio-demographic, habits and risk factors are associated with a better tensional control in type 2 diabetes in primary care patients in order to identify a specific target population for compensatory interventions improving diabetes control and reducing its morbi-mortality. MATERIAL AND METHODS: Cross-sectional study in primary care. Randomized type 2 diabetes patient data collection by their volunteer family doctors, proportionally stratified from the 5 Portuguese continental regions...
March 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28550756/reduction-of-medical-hospitalizations-in-veterans-with-schizophrenia-using-home-telehealth
#17
Leah R Flaherty, Karin Daniels, Jim Luther, Gretchen L Haas, John Kasckow
This study tested the hypothesis that addition of telehealth to Intensive Case Monitoring (ICM) would reduce hospital admissions in Veterans with schizophrenia or schizoaffective disorder admitted for psychiatric care in response to suicidal behavior. Participants (n =51) were randomized to ICM or ICM plus telehealth monitoring. Telehealth participants responded to daily electronic queries about depression, suicidality, and medication adherence. Comparisons revealed that participants in the telehealth group had significantly less medical hospitalizations than the control group...
May 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28550714/adherence-to-oral-cancer-therapy-in-older-adults-the-international-society-of-geriatric-oncology-siog-taskforce-recommendations
#18
REVIEW
Anna Rachelle Mislang, Tanya M Wildes, Ravindran Kanesvaran, Capucine Baldini, Holly M Holmes, Ginah Nightingale, Annemarie Coolbrandt, Laura Biganzoli
There is an increasing trend towards using oral systemic therapy in patients with cancer. Compared to parenteral therapy, oral cancer agents offer convenience, have similar efficacy, and are preferred by patients, consequently making its use appealing in older adults. However, adherence is required to ensure its efficacy and to avoid compromising treatment outcomes, especially when the treatment goal is curative, or in case of symptomatic/rapidly progressing disease, where dose-intensity is important. This opens a new challenge for clinicians, as optimizing patient adherence is challenging, particularly due to lack of consensus and scarcity of available clinical evidence...
May 15, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28550480/characteristics-associated-with-quality-of-life-among-people-with-drug-resistant-epilepsy
#19
Leone Ridsdale, Gabriella Wojewodka, Emily Robinson, Sabine Landau, Adam Noble, Stephanie Taylor, Mark Richardson, Gus Baker, Laura H Goldstein
Quality of Life (QoL) is the preferred outcome in non-pharmacological trials, but there is little UK population evidence of QoL in epilepsy. In advance of evaluating an epilepsy self-management course we aimed to describe, among UK participants, what clinical and psycho-social characteristics are associated with QoL. We recruited 404 adults attending specialist clinics, with at least two seizures in the prior year and measured their self-reported seizure frequency, co-morbidity, psychological distress, social characteristics, including self-mastery and stigma, and epilepsy-specific QoL (QOLIE-31-P)...
May 26, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28550422/prospective-evaluation-of-transanal-irrigation-for-fecal-incontinence-and-constipation
#20
T Juul, P Christensen
BACKGROUND: The aim of the present study was to evaluate the effect of transanal irrigation on bowel function and quality of life in a prospective cohort of Danish patients with fecal incontinence or constipation. METHODS: Patients with fecal incontinence or constipation of heterogeneous origin were treated by a specialist nurse at the Anal Physiology Clinic/Department of Surgery at Aarhus University Hospital, Aarhus, Denmark. If satisfactory results were not obtained after conservative bowel management, patients were instructed in the use the transanal irrigation procedure and were consecutively recruited for this observational cohort study in the period from March 2010 to September 2013...
May 26, 2017: Techniques in Coloproctology
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