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https://www.readbyqxmd.com/read/29783261/epidemiology-of-acute-myocardial-infarction-in-ukraine-and-poltava-region
#1
Viacheslav M Zhdan, Grigory А Oksak, Oleh V Radomskyi, Denis I Shaposhnikov
OBJECTIVE: Introduction: The number of elderly people in society is increasing. Alike in all European countries, ageing population in Ukraine is observed, which affects the structure and dynamics of morbidity and mortality of the population towards the increase of chronic non-communicable diseases, which is the epidemic of the 21st century civilization. In 2010 in Ukraine, the proportion of people over the age of 60 was 20.6% of the total. The prevalence of all diseases among the elderly in 2010 amounted to 283522,8, and among the general population - 186746,4...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783256/-psychological-features-of-the-motivation-component-in-the-training-of-doctors-in-the-system-of-postgraduate-education
#2
Svitlana Koshova, Viktoriia Horachuk, Valerii Pishchykov
OBJECTIVE: Introduction: Тhe problem of motivating adult learning in postgraduate education has so far been the subject of study primarily in methodological and pedagogical studies. They focus on the analysis of the content side of the motivation of adult learning activities. As for the problem of the dynamics of motivation for adult learning activities, including for doctors in the system of postgraduate medical education with continuous professional development, it has not been sufficiently studied so far...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783213/-socioecological-features-of-the-epidemiology-of-sarcoidosis-in-the-poltava-region-ukraine
#3
Dmytro M Boiko, Volodymyr H Pecherytsia, Oksana S Boiko, Svitlana M Kulyk
OBJECTIVE: Introduction: Lung sarcoidosis is a systemic granulomatous disease that can affect various organs and systems of a person. Due to the lack of a uniform standardized approach to the diagnosis of sarcoidosis, the epidemiological pattern is heterogeneous and depends on many factors. The aim: To investigate the correlation between the number of patients with sarcoidosis among the population of the Poltava region (Ukraine) and the ecological characteristics of the industrial activity of the region in comparison with the data on the availability of subspecialists in respiratory diseases...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783198/toxicity-assessment-of-metal-oxide-nano-pollutants-on-tomato-solanum-lycopersicon-a-study-on-growth-dynamics-and-plant-cell-death
#4
Bilal Ahmed, Mohammad Saghir Khan, Javed Musarrat
The present study for the first time demonstrated the interactions of metal oxide (MO) nano-pollutants (CuO and Al2 O3 -NPs) with tissues and cellular DNA of tomato plants grown in soil sand: silt: clay (667:190:143) and Hoagland-hydroponic system and assessed the hazardous effects of NPs on cell physiology and biochemistry. Results of SEM equipped with EDX revealed attachment of variably shaped CuO-NPs (18 nm) and Al2 O3 -NPs (21 nm) on roots, and internalization followed by translocation in plants by ICP-MS and TEM...
May 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29783049/thermopuncture-for-the-diagnosis-monitoring-and-treatment-of-patients-with-type-2-diabetes
#5
Valery Muzhikov, Elena Vershinina, Ruslan Muzhikov, Kirill Nikitin
BACKGROUND: Type 2 diabetes (T2D) is a socially significant disease that affects millions of patients. There were an estimated 366 million people with this disease in 2011, and, according to the forecast, approximately 552 million will be affected by this disease in 2030. It is well known that the primary diagnosis and treatment of a patient with this disease are quite expensive. What should be done to make it possible for a patient to monitor his own state and provide treatment in his own home using telemedicine? To solve this problem, an alternative concept for the diagnosis, monitoring, and treatment at the basis of traditional Chinese medicine (TCM) combined with mathematical methods of data processing has been used...
May 18, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29782805/maintaining-supersaturation-of-nimodipine-by-pvp-with-or-without-the-presence-of-sodium-lauryl-sulfate-and-sodium-taurocholate
#6
Yipshu Pui, Yuejie Chen, Huijun Chen, Shan Wang, Chengyu Liu, Wouter Tonnis, Linc Chen, Peter Serno, Stefan Bracht, Feng Qian
Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery system to improve the dissolution rate and oral bioavailability of poorly water soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been marketed and effectively used in clinic for nearly 30 years, yet the mechanism by which PVP maintains the supersaturation and subsequently improves the bioavailability of NMD was rarely investigated. In this research, we first studied the molecular interactions between NMD and PVP by solution NMR using CDCl3 as the solvent, and drug-polymer Flory-Huggins interaction parameter...
May 21, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29782540/monte-carlo-simulations-of-microtubule-arrays-the-critical-roles-of-rescue-transitions-the-cell-boundary-and-tubulin-concentration-in-shaping-microtubule-distributions
#7
Lynne Cassimeris, Jessica C Leung, David J Odde
Microtubules are dynamic polymers required for a number of processes, including chromosome movement in mitosis. While regulators of microtubule dynamics have been well characterized, we lack a convenient way to predict how the measured dynamic parameters shape the entire microtubule system within a cell, or how the system responds when specific parameters change in response to internal or external signals. Here we describe a Monte Carlo model to simulate an array of dynamic microtubules from parameters including the cell radius, total tubulin concentration, microtubule nucleation rate from the centrosome, and plus end dynamic instability...
2018: PloS One
https://www.readbyqxmd.com/read/29782307/cutaneous-manifestations-of-tuberous-sclerosis
#8
Mirjana Bakić, Marina Ratković, Branka Gledović, Balsa Vujović, Danilo Radunović, Vera Babić, Vladimir Prelević
Dear Editor, Tuberous sclerosis (TS) is an autosomal dominant multisystem disease, which occurs due to genetically determined hyperplasia of ectodermal and mesodermal cells. Clinical manifestations present on the skin and in the nervous system, kidneys, heart, and other organs. Recent studies estimate the incidence of TS at 1/6000 to 1/10,000 live births, and a prevalence in the general population of approximately 1 in 20,000 (1). There are two different genetic loci responsible for TS: 9q34 (TSC1-hamartin) and 16p13...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782246/precision-medicine-and-radiogenomics-in-breast-cancer-new-approaches-toward-diagnosis-and-treatment
#9
Katja Pinker, Joanne Chin, Amy N Melsaether, Elizabeth A Morris, Linda Moy
Precision medicine is medicine optimized to the genotypic and phenotypic characteristics of an individual and, when present, his or her disease. It has a host of targets, including genes and their transcripts, proteins, and metabolites. Studying precision medicine involves a systems biology approach that integrates mathematical modeling and biology genomics, transcriptomics, proteomics, and metabolomics. Moreover, precision medicine must consider not only the relatively static genetic codes of individuals, but also the dynamic and heterogeneous genetic codes of cancers...
June 2018: Radiology
https://www.readbyqxmd.com/read/29782172/assembly-dynamics-of-plasmonic-dna-capped-gold-nanoparticle-monolayers
#10
Thomas L Derrien, Michelle Zhang, Patrick Dorion, Detlef-M Smilgies, Dan Luo
The self-assembly of nanoparticles in aqueous solutions promises wide applications but requires the careful balance of many parameters not present in organic solvents. While the presence of long-range electrostatic interactions in aqueous solutions may complicate such assemblies, they provide additional parameters through which to control self-assembly. Here, with DNA-capped gold nanoparticles and through variation of the ionic strength in aqueous solutions, we explored the influence of electrostatic interactions on the adsorption of negatively charged nanoparticles on a positively charged surface...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29782019/tracking-infiltration-front-depth-using-time-lapse-multi-offset-gathers-collected-with-array-antenna-ground-penetrating-radar
#11
Hirotaka Saito, Seiichiro Kuroda, Toshiki Iwasaki, Haruyuki Fujimaki, Nobuhito Nagai, Jacopo Sala
A Ground Penetrating Radar (GPR) system based on a ground-coupled, densely populated antenna array was used to collect data during an infiltration experiment conducted at a test site near the Tottori Sand Dune, Japan. The antenna array used in this study consists of 10 transmitting antennas (Tx) and 11 receiving antennas (Rx). For this experiment, the system was configured to use all possible Tx-Rx pairings, resulting in a Multi-Offset Gather (MOG) consisting of 110 Tx-Rx combinations. The array was left stationary at a position directly above the infiltration area and data were collected every 1...
May 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29782001/a-simple-and-reproducible-method-to-prepare-membrane-samples-from-freshly-isolated-rat-brain-microvessels
#12
Hrvoje Brzica, Wazir Abdullahi, Bianca G Reilly, Patrick T Ronaldson
The blood-brain barrier (BBB) is a dynamic barrier tissue that responds to various pathophysiological and pharmacological stimuli. Such changes resulting from these stimuli can greatly modulate drug delivery to the brain and, by extension, cause considerable challenges in the treatment of central nervous system (CNS) diseases. Many BBB changes that affect pharmacotherapy, involve proteins that are localized and expressed at the level of endothelial cells. Indeed, such knowledge on BBB physiology in health and disease has sparked considerable interest in the study of these membrane proteins...
May 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781999/preparation-of-murine-submandibular-salivary-gland-for-upright-intravital-microscopy
#13
Xenia Ficht, Flavian Thelen, Bettina Stolp, Jens V Stein
The submandibular salivary gland (SMG) is one of the three major salivary glands, and is of interest for many different fields of biological research, including cell biology, oncology, dentistry, and immunology. The SMG is an exocrine gland comprised of secretory epithelial cells, myofibroblasts, endothelial cells, nerves, and extracellular matrix. Dynamic cellular processes in the rat and mouse SMG have previously been imaged, mostly using inverted multi-photon microscope systems. Here, we describe a straightforward protocol for the surgical preparation and stabilization of the murine SMG in anesthetized mice for in vivo imaging with upright multi-photon microscope systems...
May 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781998/making-testing-and-using-potassium-ion-selective-microelectrodes-in-tissue-slices-of-adult-brain
#14
J Christopher Octeau, Guido Faas, Istvan Mody, Baljit S Khakh
Potassium ions significantly contribute to the resting membrane potential of cells and, therefore, extracellular K+ concentration is a crucial regulator of cell excitability. Altered concentrations of extracellular K+ affect the resting membrane potential and cellular excitability by shifting the equilibria between closed, open and inactivated states for voltage-dependent ion channels that underlie action potential initiation and conduction. Hence, it is valuable to directly measure extracellular K+ dynamics in health and diseased states...
May 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781982/the-motor-in-implicit-motor-sequence-learning-a-foot-stepping-serial-reaction-time-task
#15
Yue Du, Jane E Clark
This protocol describes a modified serial reaction time (SRT) task used to study implicit motor sequence learning. Unlike the classic SRT task that involves finger-pressing movements while sitting, the modified SRT task requires participants to step with both feet while maintaining a standing posture. This stepping task necessitates whole body actions that impose postural challenges. The foot-stepping task complements the classic SRT task in several ways. The foot-stepping SRT task is a better proxy for the daily activities that require ongoing postural control, and thus may help us better understand sequence learning in real-life situations...
May 3, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781620/nonadiabatic-quantum-dynamics-with-frozen-width-gaussians
#16
Loic Joubert-Doriol, Artur F Izmaylov
We review techniques for simulating fully quantum nonadiabatic dynamics using the frozen-width moving Gaussian basis functions to represent the nuclear wavefunction. A choice of these basis functions is primarily motivated by the idea of the on-the-fly dynamics that will involve electronic structure calculations done locally in the vicinity of each Gaussian center and thus avoiding "curse of dimensionality'' appearing in large systems. For quantum dynamics involving multiple electronic states there are several aspects that need to be addressed...
May 21, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29781355/development-and-biological-validation-of-a-cyclic-stretch-culture-system-for-the-ex-vivo-engineering-of-tendons
#17
Manuela Teresa Raimondi, Matteo Laganà, Claudio Conci, Michele Crestani, Alessia Di Giancamillo, Francesca Gervaso, Daniela Deponti, Federica Boschetti, Michele M Nava, Chiara Scandone, Cinzia Domeneghini, Alessandro Sannino, Giuseppe M Peretti
INTRODUCTION: An innovative approach to the treatment of tendon injury or degeneration is given by engineered grafts, made available through the development of bioreactors that generate tendon tissue in vitro, by replicating in vivo conditions. This work aims at the design of a bioreactor capable of applying a stimulation of cyclic strain on cell constructs to promote the production of bioartificial tissue with mechanical and biochemical properties resembling those of the native tissue...
May 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29781187/eeg-oscillations-during-caress-like-affective-haptic-elicitation
#18
Gaetano Valenza, Alberto Greco, Matteo Bianchi, Mimma Nardelli, Simone Rossi, Enzo Pasquale Scilingo
Noninvasive, objective quantitative techniques to gauge emotional states are fundamental for clinical psychology as they overcome subjective bias of currently used questionnaires. To this end, we investigated brain oscillatory EEG activity during caresslike, affective haptic elicitation conveyed on the forearm at two force (strength of the caress) and three velocity (velocity of the caress) levels. Thirty-two healthy subjects (16 female) were asked to assess each haptic stimulus in terms of arousal (i.e., intensity of emotional perception) and valence (i...
May 20, 2018: Psychophysiology
https://www.readbyqxmd.com/read/29781138/comparison-of-the-progressive-resolution-optimizer-and-photon-optimizer-in-vmat-optimization-for-stereotactic-treatments
#19
Han Liu, Benjamin Sintay, Keith Pearman, Qingyang Shang, Lane Hayes, Jacqueline Maurer, Caroline Vanderstraeten, David Wiant
The photon optimization (PO) algorithm was recently released by Varian Medical Systems to improve volumetric modulated arc therapy (VMAT) optimization within Eclipse (Version 13.5). The purpose of this study is to compare the PO algorithm with its predecessor, progressive resolution optimizer (PRO) for lung SBRT and brain SRS treatments. A total of 30 patients were selected retrospectively. Previously, all the plans were generated with the PRO algorithm within Eclipse Version 13.6. In the new version of PO algorithm (Version 15), dynamic conformal arcs (DCA) were first conformed to the target, then VMAT inverse planning was performed to achieve the desired dose distributions...
May 20, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29780992/electrostatic-interactions-in-soft-particle-systems-mesoscale-simulations-of-ionic-liquids
#20
Yong-Lei Wang, You-Liang Zhu, Zhong-Yuan Lu, Aatto Laaksonen
Computer simulations provide a unique insight into the microscopic details, molecular interactions and dynamic behavior responsible for many distinct physicochemical properties of ionic liquids. Due to the sluggish and heterogeneous dynamics and the long-ranged nanostructured nature of ionic liquids, coarse-grained meso-scale simulations provide an indispensable complement to detailed first-principles calculations and atomistic simulations allowing studies over extended length and time scales with a modest computational cost...
May 21, 2018: Soft Matter
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