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Barret's esophagus

Guan-Yu Chen, Hua-Chuan Zheng
BACKGROUND: Dkk3 protein attenuates the expression of Wnt3a, Wnt5a and LRP6, and their interaction, and interacts with βTrCP to suppress wnt/β-catenin pathway. METHODS: We performed a bioinformatics analysis of Dkk3 mRNA expression through Oncomine, TCGA and Kaplan-Meier databases up to July 10, 2017. RESULTS: Up-regulated Dkk3 expression was higher in gastric, breast, and ovarian cancers than normal tissues (p< 0.05). Bitter's database showed a higher Dkk3 expression in ovarian cytoadenocarcinoma than clear cell adenocarcinoma (p< 0...
May 11, 2018: Cancer Biomarkers: Section A of Disease Markers
Maximilien Barret, Frédéric Prat
Endoscopy allows for the screening, early diagnosis, treatment and follow up of superficial esophageal cancer. Endoscopic submucosal dissection has become the gold standard for the resection of superficial squamous cell neoplasia. Combinations of endoscopic mucosal resection and radiofrequency ablation are the mainstay of the management of Barrett's associated neoplasia. However, protruded, non-lifting or large lesions may be better managed by endoscopic submucosal dissection. Novel ablation tools, such as argon plasma coagulation with submucosal lifting and cryoablation balloons, are being developed for the treatment of residual Barrett's esophagus, since iatrogenic strictures still hamper the development of extensive circumferential resections in the esophagus...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
F Tustumi, W M Bernardo, J R M da Rocha, S Szachnowicz, F C Seguro, E T Bianchi, R A A Sallum, I Cecconello
Achalasia of the cardia is associated with an increased risk of esophageal carcinoma. The real burden of achalasia at the malignancy genesis is still a controversial issue. Therefore, there are no generally accepted recommendations on follow-up evaluation for achalasia patients. This study aims to estimate the risk of esophageal adenocarcinoma and squamous cell carcinoma in achalasia patients. We searched for association between carcinoma and esophageal achalasia in databases up to January 2017 to perform a systematic review and meta-analysis...
October 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
M Barret, B Bordaçahar, F Beuvon, B Terris, M Camus, R Coriat, S Chaussade, F Batteux, F Prat
Esophageal stricture formation after extensive endoscopic resection remains a major limitation of endoscopic therapy for early esophageal neoplasia. This study assessed a recently developed self-assembling peptide (SAP) matrix as a wound dressing after endoscopic resection for the prevention of esophageal stricture. Ten pigs were randomly assigned to the SAP or the control group after undergoing a 5-cm-long circumferential endoscopic submucosal dissection of the lower esophagus. Esophageal diameter on endoscopy and esophagogram, weight variation, and histological measurements of fibrosis, granulation tissue, and neoepithelium were assessed in each animal...
May 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Barret Daniels, Christopher Ireland, Steven Kraus, John Racadio, Nicole Hilvert, Richard Dunn, Charles Dumoulin
BACKGROUND: Establishing postnatal nutrition delivery is challenging in neonates with immature sucking and swallowing ability. Enteral feeding is the gold standard for such patients, but their small size and fragility present challenges in nasogastric (NG) feeding tube placement. Feeding tubes are typically placed with x-ray guidance, which provides minimal soft tissue contrast and exposes the baby to ionizing radiation. This research investigates magnetic resonance (MR) guidance of NG feeding tube placement in neonates to provide improved soft tissue visualization without ionizing radiation...
November 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Ahmad Barghash, Nicole Golob-Schwarzl, Volkhard Helms, Johannes Haybaeck, Sonja M Kessler
Esophageal adenocarcinoma (EAC) represents the sixth leading cause of cancer-related deaths and develops in Barret's esophagus affected tissues. The IGF2 mRNA binding protein IMP2/IGF2BP2/p62 was originally identified as an autoantigen in hepatocellular carcinoma. Aim of this study was to investigate the expression and prognostic role of IMP2 in EAC. Human EAC and Barret's esophagus tissue showed overexpression of IMP2, particularly in tumors of increased size and in metastatic tissues. Molecular classification based on published gene signatures of esophageal cancer revealed a specific subtype, in which the expression of IMP2 is high...
August 2, 2016: Oncotarget
Mathieu Pioche, Marine Camus, Jérôme Rivory, Sarah Leblanc, Isabelle Lienhart, Maximilien Barret, Stanislas Chaussade, Jean-Christophe Saurin, Frederic Prat, Thierry Ponchon
BACKGROUND: Endoscopic resections have low morbidity and mortality. Delayed bleeding has been reported in approximately 1 - 15 % of cases, increasing with antiplatelet/anticoagulant therapy or portal hypertension. A self-assembling peptide (SAP) forming a gel could protect the mucosal defect during early healing. This retrospective trial aimed to assess the safety and efficacy of SAP in preventing delayed bleeding after endoscopic resections. METHODS: Consecutive patients with endoscopic resections were enrolled in two tertiary referral centers...
April 2016: Endoscopy International Open
Maximilien Barret, Dalhia Thao Cao, Frédéric Beuvon, Sarah Leblanc, Benoit Terris, Marine Camus, Romain Coriat, Stanislas Chaussade, Frédéric Prat
INTRODUCTION: The possible benefit of endoscopic submucosal dissection (ESD) for early neoplasia arising in Barrett's esophagus remains controversial. We aimed to assess the efficacy and safety of ESD for the treatment of early Barrett's neoplasia. METHODS: All consecutive patients undergoing ESD for the resection of a visible lesion in a Barrett's esophagus, either suspicious of submucosal infiltration or exceeding 10 mm in size, between February 2012 and January 2015 were prospectively included...
April 2016: United European Gastroenterology Journal
B Beye, M Barret, A Alatawi, F Beuvon, C Nicco, C A Pratico, C Chereau, S Chaussade, F Batteux, F Prat
The development of techniques for endoscopic resection has provided new strategies for radical conservative treatment of superficial esophageal neoplasms, even those that are circumferential, such as Barrett's neoplasia. However, it is necessary to prevent the formation of scar tissue that can be responsible for esophageal strictures following circumferential resection. Preliminary data have suggested the possible efficacy of a hemostatic powder in the promotion of wound healing. The study aims to assess the effectiveness of Hemospray (Cook Medical) in a swine model of post-endoscopic esophageal stricture...
August 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
(no author information available yet)
Gastroesophageal reflux disease (GERD) is a disorder, which gastric content repeatedly reflux into the esophagus causing disturbing symptoms and/or complications. Various epidemiological studies show that there is regional difference on the aspect of prevalence and clinical manifestation. Regional data also demonstrates increased incidence of complications such as the Barret's Esophagus and adenocarcinoma. In response to the situation, the Asia-Pacific GERD experts, including Indonesia, had published a consensus on the management of GERD in 2004, which was subsequently revised in 2008...
July 2014: Acta Medica Indonesiana
Maximilien Barret, Carlos Alberto Pratico, Marine Camus, Frédéric Beuvon, Mohamed Jarraya, Carole Nicco, Luigi Mangialavori, Stanislas Chaussade, Frédéric Batteux, Frédéric Prat
BACKGROUND AND AIMS: The prevention of esophageal strictures following circumferential mucosal resection remains a major clinical challenge. Human amniotic membrane (AM) is an easily available material, which is widely used in ophthalmology due to its wound healing, anti-inflammatory and anti-fibrotic properties. We studied the effect of AM grafts in the prevention of esophageal stricture after endoscopic submucosal dissection (ESD) in a swine model. ANIMALS AND METHODS: In this prospective, randomized controlled trial, 20 swine underwent a 5 cm-long circumferential ESD of the lower esophagus...
2014: PloS One
Maximilien Barret, Carlos Alberto Pratico, Frédéric Beuvon, Luigi Mangialavori, Ariane Chryssostalis, Marine Camus, Stanislas Chaussade, Frédéric Prat
BACKGROUND: Endoscopic esophageal piecemeal mucosectomy for high-grade dysplasia on Barrett's esophagus leads to suboptimal histologic evaluation, as well as recurrence on remaining mucosa. Circumferential en bloc mucosal resection would significantly improve the management of dysplastic Barrett's esophagus. Our aim was to describe a new method of esophageal circumferential endoscopic en bloc submucosal dissection (CESD) in a swine model. METHODS: After submucosal injection, circumferential incision was performed at each end of the esophageal segment to be removed...
October 2013: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
M Fraga, C Doerig, G Dorta, C Nichita
Barrett's esophagus consists of the replacement of normal squamous epithelium by a specialised columnar lined epithelium referred to as intestinal metaplasia in the esophagus. It represents a premalignant lesion. The prevalence of Barrett's esophagus is around 1.6%. Esophageal adenocarcinoma results from the development of dysplasia progressing from low to high grade dysplasia and finally adenocarcinoma. Radiofrequency ablation currently represents the treatment of choice in eradicating Barrett's esophagus with associated dysplasia...
September 4, 2013: Revue Médicale Suisse
J H Volders, B Witteman, A H Mulder, A Bosch, Ph M Kruyt
INTRODUCTION: Despite improvements in detection and surgical techniques perforation of the esophagus are lifethreatening. In this case report a rare presentation esophageal perforation due to Barrett's ulceration into an aortic vessel is described. PRESENTATION OF CASE: We report a 42 year old man with known Barrett's esophagus presenting with abdominal pain. Further investigations showed an active intrathoracal hemorrhage due to esophageal perforation at exactly the same site of the known Barret's ulcer one year before...
2013: International Journal of Surgery Case Reports
Maximilien Barret, Frédéric Batteux, Frédéric Beuvon, Luigi Mangialavori, Ariane Chryssostalis, Carlos Pratico, Stanislas Chaussade, Frédéric Prat
BACKGROUND: Circumferential endoscopic submucosal dissection (CESD) of the esophagus would allow for both the eradication of Barrett's esophagus and its related complications, such as advanced neoplasia. However, such procedures generally induce inflammatory repair resulting in a fibrotic stricture. N-acetylcysteine (NAC) is an antioxidant that has shown some efficacy against pulmonary and hepatic fibrosis. The aim of our study was to evaluate the benefit of NAC in the prevention of esophageal cicatricial stricture after CESD in a swine model...
May 28, 2012: Fibrogenesis & Tissue Repair
Jian Zhang, Jeremiah Bowers, Lingyan Liu, Siwei Wei, G A Nagana Gowda, Zane Hammoud, Daniel Raftery
BACKGROUND: Esophageal adenocarcinoma (EAC) is a rarely curable disease and is rapidly rising worldwide in incidence. Barret's esophagus (BE) and high-grade dysplasia (HGD) are considered major risk factors for invasive adenocarcinoma. In the current study, unbiased global metabolic profiling methods were applied to serum samples from patients with EAC, BE and HGD, and healthy individuals, in order to identify metabolite based biomarkers associated with the early stages of EAC with the goal of improving prognostication...
2012: PloS One
Zohar Levi, Alex Vilkin, Menachem Moshkowitz, Revital Kariv, Betsi Half, Yaron Niv
Barret's esophagus (BE) is defined as a situation in which the distal esophageal squamous epithelium was replaced by columnar epithelium, with or without goblet cells. BE is considered a significant risk factor for the development of esophageal cancer, however, screening is recommended only for high risk patients. The new guidelines determine the proper terminology of the endoscopic appearance of BE and the way that biopsies should be taken. After BE is confirmed, surveillance is extremely important as its performance has been shown to prevent cancer and death...
February 2011: Harefuah
A S Trukhmanov
The lecture presents modern interpretation of the term "gastroesophageal reflux disease" (GERD) and Montreal classification of this disease with emphasis on non-erosive reflux disease and risk to develop Barret's esophagus which is a widely prevalent precancer condition frequently transforming into esophageal adenocarcinoma. Description is given of GERD causes, mechanisms of development, diagnostic and differential diagnostic signs of the disease, a high risk of bronchial asthma in GERD patients, basic treatment principles including healthy way of life, pharmacotherapy (antacids, alginates, prokinetics, proton pump inhibitors, etc...
2011: Terapevticheskiĭ Arkhiv
Anouk van de Winkel, Katinka P M van Zoest, Herman van Dekken, Leon M G Moons, Ernst J Kuipers, Luc J W van der Laan
AIMS: To investigate expression of nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) as a diagnostic tool to improve grading of dysplasia in Barrett's oesophagus patients. METHODS AND RESULTS: Immunostaining was analysed on a total of 192 biopsy samples of 22 Barrett's patients with no dysplasia (ND), 17 with low-grade dysplasia (LGD), 20 high-grade dysplasia (HGD) and 24 with adenocarcinoma (AC). Nuclear FXR expression was observed in 15 of 22 (68%) ND cases versus none of 19 HGD; 3 of 17 (18%); LGD; 5 of 60 (8%) patients with AC (P<0...
January 2011: Histopathology
Tomás Alarcón, Henrik Jeldtoft Jensen
We study the invasion dynamics of a mutant population characterized by an increased phenotypic variability with respect to the incumbent population, with an emphasis on the effects of increased phenotypic robustness and fluctuations induced by small system size. This model is based on recent experimental and theoretical results which hint at the possibility that inactivation of certain genes, either by the effect of mutations or by pharmacological intervention, leads to the liberation of cryptic genetic variation which, in turn, produces a host of new phenotypic variants...
March 2012: Mathematical Medicine and Biology: a Journal of the IMA
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