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Long term use of omeprazole

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https://www.readbyqxmd.com/read/28056809/is-the-concomitant-use-of-clopidogrel-and-proton-pump-inhibitors-still-associated-with-increased-adverse-cardiovascular-outcomes-following-coronary-angioplasty-a-systematic-review-and-meta-analysis-of-recently-published-studies-2012-2016
#1
Pravesh Kumar Bundhun, Abhishek Rishikesh Teeluck, Akash Bhurtu, Wei-Qiang Huang
BACKGROUND: Controversies were previously observed with the concomitant use of clopidogrel and Proton Pump Inhibitors (PPIs), especially omeprazole, following coronary angioplasty. Even though several studies showed no interaction between clopidogrel and PPIs, questions have been raised about the decrease in antiplatelet effects of clopidogrel with PPIs. A previously published meta-analysis showed concomitant use of clopidogrel and PPIs to be associated with higher adverse cardiovascular outcomes...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28045652/the-influence-of-changes-in-hospital-drug-formulary-on-the-prescription-of-proton-pump-inhibitors
#2
Raquel Vázquez-Mourelle, Eduardo Carracedo-Martínez
OBJECTIVE: To analyze the impact of introducing omeprazole in the drug formulary of the Hospital de Barbanza on prescriptions made in hospital and out-of-hospital (Outpatient Units and Primary Care) for all Proton Pump Inhibitors (PPIs). MATERIAL AND METHODS: A 36-month retrospective descriptive study in a level I hospital. The basic units of work are Dose-Population- Day in the outpatient setting, and the Defined Daily Dose/stays-day for hospitalized patients; the proportion of DDDs for omeprazole vs...
January 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28039570/different-transcriptional-profiling-between-senescent-and-non-senescent-human-coronary-artery-endothelial-cells-hcaecs-by-omeprazole-and-lansoprazole-treatment
#3
Laura Costarelli, Robertina Giacconi, Marco Malavolta, Andrea Basso, Francesco Piacenza, Mauro Provinciali, Marcello G Maggio, Andrea Corsonello, Fabrizia Lattanzio
Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the genesis or promotion of age-related cardiovascular disease, we hypothesized an active role of PPIs in senescent cells. The aim of this study is to investigate the changes in gene expression occurring in senescent and non-senescent human coronary artery endothelial cells (HCAECs) following Omeprazole (OPZ) or Lansoprazole (LPZ) treatment...
December 30, 2016: Biogerontology
https://www.readbyqxmd.com/read/27882276/isolated-non-traumatic-bilateral-coronoid-process-fracture-of-the-mandible
#4
Nabil Al-Khalisi, Krishna Kumar, Natasha Acosta
Isolated bilateral fractures of the coronoid processes of the mandible occurred in this patient without any significant trauma. The definite etiology of this case is unknown, but possible causes or contributing factors may include acute reflex contraction of the patient's temporalis muscles leading to bilateral stress fractures, coronoid process hyperplasia, or the patient's long-term use of omeprazole. The planned treatment for this patient included pain control with Mobic and tramadol and splint fabrication followed by arch bar placement with training elastics for six weeks...
October 13, 2016: Curēus
https://www.readbyqxmd.com/read/27866273/omeprazole-suppressed-plasma-magnesium-level-and-duodenal-magnesium-absorption-in-male-sprague-dawley-rats
#5
Narongrit Thongon, Jirawat Penguy, Sasikan Kulwong, Kanyanat Khongmueang, Matthana Thongma
Hypomagnesemia is the most concerned side effect of proton pump inhibitors (PPIs) in chronic users. However, the mechanism of PPIs-induced systemic Mg(2+) deficit is currently unclear. The present study aimed to elucidate the direct effect of short-term and long-term PPIs administrations on whole body Mg(2+) homeostasis and duodenal Mg(2+) absorption in rats. Mg(2+) homeostasis was studied by determining the serum Mg(2+) level, urine and fecal Mg(2+) excretions, and bone and muscle Mg(2+) contents. Duodenal Mg(2+) absorption as well as paracellular charge selectivity were studied...
November 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27865855/intestinal-response-to-salinity-challenge-in-the-senegalese-sole-solea-senegalensis
#6
I Ruiz-Jarabo, A Barany, I Jerez-Cepa, J M Mancera, J Fuentes
Fish are continuously forced to actively absorb or expel water and ions through epithelia. Most studies have focused on the gill due to its role in Na(+) and Cl(-) trafficking. However, comparatively few studies have focused on the changing function of the intestine in response to external salinity. Therefore, the present study investigated the main intestinal changes of long-term acclimation of the Senegalese sole (Solea senegalensis) to 5, 15, 38 and 55ppt. Through the measurement of short-circuit current (Isc) in Ussing chambers and biochemical approaches, we described a clear anterior/posterior functional regionalization of the intestine in response to salinity...
February 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27759759/human-immunodeficiency-virus-in-institutionalized-elderly-people
#7
Milton Luiz Gorzoni, Sueli Luciano Pires, Lilian de Fátima Costa Faria, Márcia Regina Valadares Aguado, Miriam Carmen Santana
CONTEXT AND OBJECTIVE: A search in the SciELO and PubMed databases showed few studies on human immunodeficiency virus (HIV) positive individuals in long-term care institutions (LTCIs), thus prompting the present study. The aim of this study was to ascertain whether there were any HIV-positive individuals in LTCIs for the elderly. DESIGN AND SETTING: Cross-sectional study in which the Hospital Infection Control Committee (HICC) of a 405-bed LTCI was consulted. METHODS: The medical records of 405 individuals interned in the LTCI who had been tested for HIV infection were requested for analysis of the following variables: [1] age and gender; [2] length of stay at LTCI (months); [3] causes and diagnoses on admission to LTCI according to International Classification of Diseases, 10th edition; [4] date of HIV diagnosis; [5] seropositivity for syphilis and hepatitis B and C viruses; [6] medications used at last prescription in medical file; and [7] mean CD4 lymphocyte count based on: total lymphocyte count/6 and total lymphocyte count x 0...
October 13, 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27622015/ranitidine-modifies-myeloid-cell-populations-and-inhibits-breast-tumor-development-and-spread-in-mice
#8
Ava Vila-Leahey, Sharon A Oldford, Paola A Marignani, Jun Wang, Ian D Haidl, Jean S Marshall
Histamine receptor 2 (H2) antagonists are widely used clinically for the control of gastrointestinal symptoms, but also impact immune function. They have been reported to reduce tumor growth in established colon and lung cancer models. Histamine has also been reported to modify populations of myeloid-derived suppressor cells (MDSCs). We have examined the impact of the widely used H2 antagonist ranitidine, on both myeloid cell populations and tumor development and spread, in three distinct models of breast cancer that highlight different stages of cancer progression...
July 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27577963/proton-pump-inhibitor-monotherapy-and-the-risk-of-cardiovascular-events-in-patients-with-gastro-esophageal-reflux-disease-a-meta-analysis
#9
S Sun, Z Cui, M Zhou, R Li, H Li, S Zhang, Y Ba, G Cheng
BACKGROUND AND PURPOSE: Proton pump inhibitors (PPIs) are commonly used as potent gastric acid secretion antagonists for gastro-esophageal disorders and their overall safety in patients with gastro-esophageal reflux disease (GERD) is considered to be good and they are well-tolerated. However, recent studies have suggested that PPIs may be a potential independent risk factor for cardiovascular adverse events. The aim of our meta-analysis was to examine the association between PPI monotherapy and cardiovascular events in patients with GERD...
August 30, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27539734/proton-pump-inhibitors-risk-for-myopathy
#10
REVIEW
Evan W Colmenares, Ashley L Pappas
OBJECTIVE: The purpose of this article is to describe the relationship between proton pump inhibitors (PPIs) and symptoms of myopathy based on case reports. DATA SOURCES: A literature search was conducted in PubMed (1946 to June 2016) using MeSH terms proton pump inhibitors, omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole, pantoprazole, and muscular diseases Additionally, a search was conducted in ToxNet and EMBASE using similar search criteria...
August 18, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27228533/ultrasound-guided-phrenic-nerve-block-for-intractable-hiccups-following-placement-of-esophageal-stent-for-esophageal-squamous-cell-carcinoma
#11
David Arsanious, Spiro Khoury, Edgar Martinez, Ali Nawras, Gregory Filatoff, Hossam Ajabnoor, Umar Darr, Joseph Atallah
UNLABELLED: Hiccups are actions consisting of sudden contractions of the diaphragm and intercostals followed by a sudden inspiration and transient closure of the vocal cords. They are generally short lived and benign; however, in extreme and rare cases, such as esophageal carcinoma, they can become persistent or intractable, up to and involving significant pain, dramatically impacting the patient's quality of life. This case involves a 60-year-old man with a known history of squamous cell carcinoma of the esophagus...
May 2016: Pain Physician
https://www.readbyqxmd.com/read/27137875/medical-and-non-medical-predictors-of-initiating-long-term-use-of-proton-pump-inhibitors-a-nationwide-cohort-study-of-first-time-users-during-a-10-year-period
#12
P F Haastrup, M S Paulsen, R D Christensen, J Søndergaard, J M Hansen, D E Jarbøl
BACKGROUND: Studies of the increasing use of proton pump inhibitors (PPIs) have mainly focused on prevalent long-term use and associations with gastrointestinal morbidity and comedication. Little is known about non-medical characteristics of first-time users of PPI, and predictors of initiating long-term use of PPIs. AIMS: To describe medical and non-medical characteristics of first-time PPI users during a 10-year period and to analyse predictors of initiation of long-term use (>60 defined daily doses (DDDs) within 6 months) of PPIs...
July 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/26878253/an-approach-to-the-diagnosis-and-management-of-a-case-presenting-with-recurrent-hypomagnesemia-secondary-to-the-chronic-use-of-a-proton-pump-inhibitor
#13
Lívia Marcela dos Santos, Ricardo Ayello Guerra, Marise Lazaretti-Castro, José Gilberto H Vieira, Evandro de Souza Portes, Magnus R Dias-da-Silva
PURPOSE: Magnesium is an important electrolyte for very many cell functions and its deficiency may lead to a wide spectrum of diseases. We report a clinical case of hypomagnesemia resulting from the chronic use of a proton pump inhibitor (PPI). PPIs are drugs widely used in medical practice, and a growing number of cases of PPIs causing hypomagnesemia have been described. Our aim was to monitor the clinical and electrolyte findings during recovery from hypomagnesemia caused by long-term PPI use...
December 2015: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/26715503/solitary-gastric-carcinoid-tumor-associated-with-long-term-use-of-omeprazole-a-case-report-and-review-of-the-literature
#14
REVIEW
Nina Nandy, Joshua A Hanson, Robert G Strickland, Denis M McCarthy
No abstract text is available yet for this article.
March 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26537905/long-term-follow-up-results-of-endoscopic-treatment-of-gastroesophageal-reflux-disease-with-the-muse%C3%A2-endoscopic-stapling-device
#15
Hong Joo Kim, Chang-Il Kwon, William R Kessler, Don J Selzer, Gail McNulty, Amol Bapaye, Luigi Bonavina, Glen A Lehman
BACKGROUND: The initial 6-month data for MUSE™ (Medigus, Omer, Israel) endoscopic stapling device were reported (Zacherl et al. in Surg Endosc 29:220-229, 2015). The current study aims to evaluate the long-term clinical outcome of 37 patients who received endoscopic gastroesophageal reflux disease (GERD) treatment with the MUSE™ device. METHODS: Efficacy and safety data for 37 patients were analyzed at baseline, 6 months, and 4 years post-procedure. In one center (IU), efficacy and safety data were evaluated at baseline, 6 months post-procedure, and then annually up to 4 years...
August 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26229922/effects-of-long-term-administration-of-omeprazole-on-bone-mineral-density-and-the-mechanical-properties-of-the-bone
#16
Gabriela Rezende Yanagihara, Aline Goulart de Paiva, Maurílio Pacheco Neto, Larissa Helena Torres, Antônio Carlos Shimano, Mário Jefferson Quirino Louzada, Raquel Annoni, Álvaro César de Oliveira Penoni
OBJECTIVES: Epidemiological studies have shown a relationship between long-term use of proton pump inhibitors and bone metabolism. However, this relationship has not yet become established. The aim of the present study was to analyze the mechanical properties and bone mineral density (BMD) of rats that were subjected to long-term omeprazole use. METHODS: Fifty Wistar rats weighing between 200 and 240 g were divided equally into five groups: OMP300 (omeprazole intake at a dose of 300 μmoL/kg/day); OMP200 (200 μmoL/kg/day); OMP40 (40 μmoL/kg/day); OMP10 (10 μmoL/kg/day); and Cont (control group; intake of dilution vehicle)...
March 2015: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/26061682/the-cost-effectiveness-of-celecoxib-versus-non-steroidal-anti-inflammatory-drugs-plus-proton-pump-inhibitors-in-the-treatment-of-osteoarthritis-in-saudi-arabia
#17
Sherif A Nasef, A Aziz Shaaban, Joaquin Mould-Quevedo, Tarek A Ismail
BACKGROUND: Cyclooxygenase (COX)-2 inhibitors including celecoxib are as effective as non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs) in the treatment of osteoarthritis (OA) and have less gastrointestinal toxicity. Although they are associated with higher treatment costs, COX-2 inhibitors may simultaneously reduce costs associated with adverse events, hence, their overall economic benefit should be assessed. OBJECTIVE: To evaluate the incremental cost effectiveness ratio (ICER) of celecoxib versus ns-NSAIDs, with/without proton-pump inhibitor (PPI) co-therapy, for managing OA in Saudi Arabian subjects aged ≥65 years...
December 2015: Health Economics Review
https://www.readbyqxmd.com/read/25966865/-pain-medication-in-nursing-home-residents-with-and-without-cancer-most-frequently-with-metamizole
#18
J Schulze, M H Freitag, G Glaeske, G Schmiemann, F Hoffmann
BACKGROUND: Pain is a highly prevalent symptom in nursing home residents. The analgesic pharmacotherapy of older adults is associated with challenges; however, studies from Germany examining the prescription pattern of analgesics in nursing home residents are rare. OBJECTIVES: This study was carried out to examine the prescription of analgesics in nursing home residents with and without the diagnosis of cancer. MATERIAL AND METHODS: Using health insurance claims data persons aged ≥ 65 years who were newly admitted to a nursing home between 2004 and 2009 and who survived at least the first 90 days after admission were included in the study...
July 2015: Der Schmerz
https://www.readbyqxmd.com/read/25858519/long-term-safety-of-proton-pump-inhibitor-therapy-assessed-under-controlled-randomised-clinical-trial-conditions-data-from-the-sopran-and-lotus-studies
#19
COMPARATIVE STUDY
S E Attwood, C Ell, J P Galmiche, R Fiocca, J G Hatlebakk, B Hasselgren, G Långström, M Jahreskog, S Eklund, T Lind, L Lundell
BACKGROUND: Control of chronic gastro-oesophageal reflux disease may be achieved either by anti-reflux surgery (ARS) or by long-term medical therapy with proton pump inhibitors (PPIs). The primary efficacy results of the SOPRAN study, comparing long-term omeprazole use with open ARS, and the LOTUS study, comparing long-term esomeprazole use with laparoscopic ARS, have been reported. A secondary objective of these studies was to address the long-term safety of these respective therapeutic strategies and thereby provide a valid scientific platform for assessing long-term PPI safety...
June 2015: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/25857639/the-physiological-background-behind-and-course-of-development-of-the-first-proton-pump-inhibitor
#20
REVIEW
Lars Lundell
UNLABELLED: Gastric acid secretion and its related diseases and their treatments have generated important contributions to gastroenterology and its development as an autonomous medical specialty. The discovery of histamine receptors and the subsequent H2-receptor antagonists (1972) changed the practice of gastroenterology forever. Gastric acid was effectively inhibited and ulcers could be healed to an extent which had not previously been seen. An additional milestone along the same avenue was offered by the identification of hydrogen potassium adenosine triphosphatase (H(+)K(+)-ATPase) as the proton pump of the parietal cell...
June 2015: Scandinavian Journal of Gastroenterology
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