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https://www.readbyqxmd.com/read/28151401/left-ventricular-structure-and-function-in-relation-to-environmental-exposure-to-lead-and-cadmium
#1
Wen-Yi Yang, Zhen-Yu Zhang, Lutgarde Thijs, Nicholas Cauwenberghs, Fang-Fei Wei, Lotte Jacobs, Aernout Luttun, Peter Verhamme, Tatiana Kuznetsova, Tim S Nawrot, Jan A Staessen
BACKGROUND: Experimental studies have demonstrated that lead and cadmium have direct toxic effects on the myocardium, but the few human studies are limited by design, assessment of exposure, and use of heart failure as a late-stage endpoint. METHODS AND RESULTS: In a prospective population study, we studied the association of left ventricular (LV) function with blood lead (BPb) and 24-hour urinary cadmium (UCd). In 179 participants randomly recruited from a Flemish population (50...
February 1, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28143592/tracking-platyhelminth-parasite-diversity-from-freshwater-turtles-in-french-guiana-first-report-of-neopolystoma-price-1939%C3%A2-monogenea-polystomatidae-with-the-description-of-three-new-species
#2
Louis H Du Preez, Mathieu Badets, Laurent Héritier, Olivier Verneau
BACKGROUND: Polystomatid flatworms in chelonians are divided into three genera, i.e. Polystomoides Ward, 1917, Polystomoidella Price, 1939 and Neopolystoma Price, 1939, according to the number of haptoral hooks. Among the about 55 polystome species that are known to date from the 327 modern living chelonians, only four species of Polystomoides are currently recognised within the 45 South American freshwater turtles. METHODS: During 2012, several sites in the vicinity of the cities Cayenne and Kaw in French Guiana were investigated for freshwater turtles...
January 31, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28138432/spontaneous-nephrocutaneous-fistula-rare-complication-of-xanthogranulomatous-pyelonephritis
#3
Rami Alazab, Hamzeh M Ghawanmeh, Faris Abushamma, Omar Ababneh, Anas I Al-Karasneh
Renocutaneous fistulae may occur as a result of chronic infection, especially in the setting of calculous disease.(1) Spontaneous renocutaneous is rare.(2) Usually nephrocutanous fistula developed in patient with previous renal surgery, trauma, tumors, and chronic urinary tract infection with abscess formation. We report a case of spontaneous nephrocutaneous fistula. A 37-year-old women previously well presented to ER department with purulent discharge and a palpable mass on the left lumbar area. CT scan with IV contrast fistulous tract seen within the subcutaneous plane in Left lumbar region tracking towards retroperitoneal space, and in continuity with of left kidney...
February 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28114076/a-multi-technique-reconfigurable-electrochemical-biosensor-enabling-personal-health-monitoring-in-mobile-devices
#4
Alexander Sun, A G Venkatesh, Drew A Hall
This paper describes the design and characterization of a reconfigurable, multi-technique electrochemical biosensor designed for direct integration into smartphone and wearable technologies to enable remote and accurate personal health monitoring. By repurposing components from one mode to the next, the biosensor's potentiostat is able reconfigure itself into three different measurements modes to perform amperometric, potentiometric, and impedance spectroscopic tests all with minimal redundant devices. A [Formula: see text] PCB prototype of the module was developed with discrete components and tested using Google's Project Ara modular smartphone...
September 26, 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28113176/a-multi-technique-reconfigurable-electrochemical-biosensor-enabling-personal-health-monitoring-in-mobile-devices
#5
Alexander Sun, A G Venkatesh, Drew A Hall
This paper describes the design and characterization of a reconfigurable, multi-technique electrochemical biosensor designed for direct integration into smartphone and wearable technologies to enable remote and accurate personal health monitoring. By repurposing components from one mode to the next, the biosensor's potentiostat is able reconfigure itself into three different measurements modes to perform amperometric, potentiometric, and impedance spectroscopic tests all with minimal redundant devices. A [Formula: see text] PCB prototype of the module was developed with discrete components and tested using Google's Project Ara modular smartphone...
October 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28074019/point-organ-radiation-dose-in-abdominal-ct-effect-of-patient-off-centering-in-an-experimental-human-cadaver-study
#6
Ranish Deedar Ali Khawaja, Sarabjeet Singh, Atul Padole, Alexi Otrakji, Diego Lira, Da Zhang, Bob Liu, Andrew Primak, George Xu, Mannudeep K Kalra
To determine the effect of patient off-centering on point organ radiation dose measurements in a human cadaver scanned with routine abdominal CT protocol. A human cadaver (88 years, body-mass-index 20 kg/m(2)) was scanned with routine abdominal CT protocol on 128-slice dual source MDCT (Definition Flash, Siemens). A total of 18 scans were performed using two scan protocols (a) 120 kV-200 mAs fixed-mA (CTDIvol 14 mGy) (b) 120 kV-125 ref mAs (7 mGy) with automatic exposure control (AEC, CareDose 4D) at three different positions (a) gantry isocenter, (b) upward off-centering and (c) downward off-centering...
January 10, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28068467/exodisc-for-rapid-size-selective-and-efficient-isolation-and-analysis-of-nanoscale-extracellular-vesicles-from-biological-samples
#7
Hyun-Kyung Woo, Vijaya Sunkara, Juhee Park, Tae-Hyeong Kim, Ja-Ryoung Han, Chi-Ju Kim, Hyun-Il Choi, Yoon-Keun Kim, Yoon-Kyoung Cho
Extracellular vesicles (EVs) are cell-derived, nanoscale vesicles that carry nucleic acids and proteins from their cells of origin and show great potential as biomarkers for many diseases, including cancer. Efficient isolation and detection methods are prerequisites for exploiting their use in clinical settings and understanding their physiological functions. Here, we presented a rapid, label-free, and highly sensitive method for EV isolation and quantification using a lab-on-a-disc integrated with two nanofilters (Exodisc)...
January 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28009729/impact-of-enhanced-recovery-after-surgery-and-fast-track-surgery-pathways-on-healthcare-associated-infections-results-from-a-systematic-review-and-meta-analysis
#8
Michael C Grant, Dongjie Yang, Christopher L Wu, Martin A Makary, Elizabeth C Wick
OBJECTIVE: The aim of this study was to establish if enhanced recovery after surgery (ERAS) and fast track surgery (FTS) protocols are associated with reduction in healthcare-associated infection (HAIs). BACKGROUND: Evidence suggests that prevention strategies for HAIs should be multifaceted and transdisciplinary. ERAS and FTS protocols are collaborative approaches to perioperative care which reduce length of stay but may also be an effective strategy for reducing HAIs...
January 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28005930/nanoparticle-tracking-analysis-for-the-enumeration-and-characterization-of-mineralo-organic-nanoparticles-in-feline-urine
#9
M Mellema, M Stoller, Y Queau, S P Ho, T Chi, J A Larsen, N Passlack, A J Fascetti, C Mohr, J L Westropp
Urinary stone disease, particularly calcium oxalate, is common in both humans and cats. Calcifying nanoparticles (CNP) are spherical nanocrystallite material, and are composed of proteins (fetuin, albumin) and inorganic minerals. CNP are suggested to play a role in a wide array of pathologic mineralization syndromes including urolithiasis. We documented the development of a clinically relevant protocol to assess urinary CNP in 9 healthy cats consuming the same diet in a controlled environment using Nanoparticle Tracking Analysis (NTA®)...
2016: PloS One
https://www.readbyqxmd.com/read/28004150/assessment-of-urinary-microparticles-in-normotensive-patients-with-type-1-diabetes
#10
Yuliya Lytvyn, Fengxia Xiao, Christopher R J Kennedy, Bruce A Perkins, Heather N Reich, James W Scholey, David Z Cherney, Dylan Burger
AIMS/HYPOTHESIS: Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 diabetes and acute hyperglycaemia would increase urinary podocyte MP levels in uncomplicated diabetes. METHODS: In this post hoc exploratory analysis, we examined archived urine samples from normoalbuminuric patients with uncomplicated type 1 diabetes studied under clamped euglycaemia and hyperglycaemia and compared with healthy controls...
March 2017: Diabetologia
https://www.readbyqxmd.com/read/27999027/gut-sparing-treatment-of-urinary-tract-infection-in-patients-at-high-risk-of-clostridium-difficile-infection
#11
Christopher Staley, Byron P Vaughn, Carolyn T Graiziger, Michael J Sadowsky, Alexander Khoruts
BACKGROUND: Recipients of faecal microbiota transplantation (FMT) in treatment of recurrent Clostridium difficile infection (RCDI) remain at markedly increased risk of re-infection with C. difficile with new antibiotic provocations. Urinary tract infections (UTIs) are common indications for antibiotics in these patients, often resulting in C. difficile re-infection. METHODS: We present a case series of 19 patients treated with parenteral aminoglycosides for UTI following FMT for RCDI...
February 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27998182/investigation-of-transrenal-kras-mutation-in-late-stage-nsclc-patients-correlates-to-disease-progression
#12
Xiaojiang Wang, Qinghua Meng, Chuanhai Wang, Fajiu Li, Zhiyang Zhu, Shuang Liu, Yi Shi, Jie Huang, Shi Chen, Chenghong Li
PURPOSE: Using transrenal DNA to detect KRAS mutations in non-small cell lung cancer (NSCLC), the study addressed the clinical impact for longitudinal monitoring and prognostic value for disease outcome. METHODS: Digital droplet PCR was used to detect the mutant DNA. A total of 200 NSCLC patients were recruited with varying molecular profiles. To ascertain the specificity of transrenal DNA to accurately profile the disease, primary tissues were compared. Subsequently, serial samplings were performed at different treatment cycles to gauge the predictive value...
December 21, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27917728/comparing-catheter-associated-urinary-tract-infection-prevention-programs-between-veterans-affairs-nursing-homes-and-non-veterans-affairs-nursing-homes
#13
Lona Mody, M Todd Greene, Sanjay Saint, Jennifer Meddings, Barbara W Trautner, Heidi L Wald, Christopher Crnich, Jane Banaszak-Holl, Sara E McNamara, Beth J King, Robert Hogikyan, Barbara S Edson, Sarah L Krein
OBJECTIVE The impact of healthcare system integration on infection prevention programs is unknown. Using catheter-associated urinary tract infection (CAUTI) prevention as an example, we hypothesize that US Department of Veterans Affairs (VA) nursing homes have a more robust infection prevention infrastructure due to integration and centralization compared with non-VA nursing homes. SETTING VA and non-VA nursing homes participating in the AHRQ Safety Program for Long-Term Care collaborative. METHODS Nursing homes provided baseline information about their infection prevention programs to assess strengths and gaps related to CAUTI prevention via a needs assessment questionnaire...
December 5, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27908456/wastewater-based-epidemiology-to-assess-human-exposure-to-pyrethroid-pesticides
#14
Nikolaos I Rousis, Ettore Zuccato, Sara Castiglioni
Pesticides are active substances with potentially adverse effects on human health, and therefore great effort is addressed to study the relation between their widespread use and the effects on humans. To track human exposure to pesticides, novel approaches are needed to give additional information on exposure at population level. In this study, a novel application of Wastewater-Based Epidemiology (WBE) was developed to measure the intake of pyrethroid pesticides in a population. Three human urinary metabolites of pyrethroids were selected and validated as biomarkers of exposure by evaluating their sources and stability in wastewater...
November 28, 2016: Environment International
https://www.readbyqxmd.com/read/27869620/safety-and-outcomes-of-inpatient-compared-with-outpatient-surgical-procedures-for-ankle-fractures
#15
Charles Qin, Robert G Dekker, Jordan T Blough, Anish R Kadakia
BACKGROUND: As the cost of health-care delivery rises in the era of bundled payments for care, there is an impetus toward minimizing hospitalization. Evidence to support the safety of open reduction and internal fixation (ORIF) of ankle fractures in the outpatient setting is largely anecdotal. METHODS: Patients who underwent ORIF from 2005 to 2013 were identified via postoperative diagnoses of ankle fracture and Current Procedural Terminology codes; patients with open fractures and patients who were emergency cases were excluded...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27851899/cognitive-ability-in-down-syndrome-and-its-relationship-to-urinary-neopterin-a-marker-of-activated-cellular-immunity
#16
Panagiotis Zis, André Strydom, David Buckley, Daniel Adekitan, Patrick C McHugh
BACKGROUND: Neopterin is an unconjugated pteridine that is secreted in large quantities by activated macrophages and can be used as a clinical marker of activated cellular immunity and oxidative stress. We aimed to investigate whether urinary neopterin levels are associated with cognitive function in people with Down syndrome (DS). METHODS: Out of 32 adults with DS who originally participated in a longitudinal study, 25 were followed up at 4 years. Informants rated their adaptive behavior (ABAS) and the adults with DS attempted assessments of language skills and memory at both baseline and follow-up time points (Modified Memory Object Task, MOMT), and receptive vocabulary (British Picture Vocabulary Scale, BPVS)...
January 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27805758/exploring-relationships-of-catheter-associated-urinary-tract-infection-and-blockage-in-people-with-long-term-indwelling-urinary-catheters
#17
Mary H Wilde, James M McMahon, Hugh F Crean, Judith Brasch
AIMS: The aims were to describe and explore relationships among catheter problems in long-term indwelling urinary catheter users, including excess health care utilization for treating catheter problems. BACKGROUND: Long-term urinary catheter users experience repeated problems with catheter-related urinary tract infection (CAUTI) and blockage of the device, yet little has been reported of the patterns and relationships among relevant catheter variables. DESIGN: Secondary data analysis was conducted from a sample in a randomized clinical trial, using data from the entire sample of 202 persons over 12 months' participation...
November 2, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27793529/-intraprostatic-fiducials-in-stereotactic-radiotherapy-for-prostate-cancer
#18
A Cordoba, D Pasquier, P Nickers, T Lacornerie, É Lartigau
PURPOSE: Image-guided radiotherapy for prostate cancer is widely used in radiotherapy departments. Intraprostatic gold fiducial markers are used to visualize prostate position and motion before and during treatment. The aim of this report is to describe our experience of implanting intraprostatic fiducial markers under local anesthesia before hypofractionated stereotactic radiotherapy for prostate cancer and to assess its tolerance and reproducibility. PATIENTS AND METHODS: Over a 6 and a half year period, 226 patients with prostate cancer received a stereotactic radiotherapy using the CyberKnife(®) system (Accuray) in our institution...
December 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27771514/keepex-a-simple-dilution-protocol-for-improving-extracellular-vesicle-yields-from-urine
#19
M Puhka, M-E Nordberg, S Valkonen, A Rannikko, O Kallioniemi, P Siljander, T M Af Hällström
Urinary extracellular vesicles (EVs) are a promising source of biomarkers, which can be obtained in a non-invasive manner. However, the yield of EVs from urine samples may be insufficient for various analyses due to the entrapment of EVs by the Tamm-Horsfall protein (THP) meshwork. Here, we developed a simple dilution protocol to increase the urinary EV yield by disrupting the interaction between THP filaments and EVs with the help of alkaline pH and lowered ionic concentration. The integrity of the EVs and THP was assessed by electron microscopy...
October 19, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27747785/growth-hormone-concentrations-in-different-body-fluids-before-and-after-moderate-exercise
#20
Liz Gough, Lindy M Castell, Rosalba Gatti, Richard J Godfrey
BACKGROUND: Growth hormone (GH) has many direct and indirect actions and roles including substrate regulation and priming of some cells of the immune system, and the expected aspects of growth and repair. Different concentrations in human body fluids reflect the exercise-induced growth hormone response (EIGR) after exercise. In populations such as elite athletes, the invasive nature of venous sampling is poorly accepted. Thus, this study examines possible viable alternatives such as urine and saliva samples and the GH concentration...
December 2016: Sports Medicine—Open
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