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https://www.readbyqxmd.com/read/28789796/the-bidirectional-relationship-between-anxiety-depression-and-lower-urinary-track-symptoms-a-nationwide-population-based-cohort-study
#1
Charles Lung-Cheng Huang, Ming-Ping Wu, Chung-Han Ho, Jhi-Joung Wang
BACKGROUND: Evidence has shown a positive correlation between lower urinary tract symptoms (LUTS) and anxiety/depression, but the direction and strength of the association are still unclear. We aimed to test the bidirectional association between LUTS and anxiety/depression using a longitudinal population database. METHODS: Using claims data obtained from the Taiwan National Health Insurance Research Database, 17,489 patients with LUTS and 34,978 non-LUTS matched controls (cohort 1); and 45,707 patients with anxiety, 19,306 patients with depression, 91,414 non-anxiety, and 38,720 non-depression matched controls (cohort 2) were enrolled between 1999 and 2008...
September 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28774377/association-of-estimated-sodium%C3%A2-intake%C3%A2-with-adverse-cardiac-structure-and%C3%A2-function-from-the-hypergen-study
#2
Senthil Selvaraj, Luc Djoussé, Frank G Aguilar, Eva E Martinez, Vincenzo B Polsinelli, Marguerite R Irvin, Donna K Arnett, Sanjiv J Shah
BACKGROUND: The optimal level of sodium intake remains controversial. OBJECTIVES: This study sought to determine whether examination of left ventricular longitudinal strain (LS), circumferential strain, and e' velocity can provide insight into thresholds for the detrimental effects of estimated sodium intake (ESI) on subclinical cardiovascular disease. METHODS: We performed speckle-tracking analysis on HyperGEN (Hypertension Genetic Epidemiology Network) study echocardiograms with available urinary sodium data (N = 2,996)...
August 8, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28771063/reliability-of-urinary-dehydration-markers-among-elite-youth-boxers
#3
Damir Zubac, Drazen Cular, Uros Marusic
PURPOSE: The aim of the present study was to determine the reliability and diagnostic accuracy of non-invasive urinary dehydration markers, in field-based settings on a day-to-day basis in elite adolescent amateur boxers. METHODS: Sixty-nine urine samples were collected on a day-to-day basis, from twenty-three athletes (17.3±1.9 y), during their weigh-stable phase and analyzed by field and laboratory measures of hydration status. Urine osmolality (UOSM), urine specific gravity (USG), total protein content (TPC) and body-mass (BM) stability were evaluated to determine fluid balance and hydration status...
August 3, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28764970/urinary-exosomal-mir-2909-a-novel-pathognomonic-trait-of-prostate-cancer-severity
#4
S Wani, D Kaul, R S Mavuduru, N Kakkar, A Bhatia
The global occurrence of prostate cancer with a range of patient outcome has prompted various investigators to explore novel molecular biomarkers that can precisely detect and track this type of cancer severity. Several studies suggest that micro-RNAs have emerged to act as a new largely unexplored class of biomarkers because of their inherent stability, resilience and recruitment into exosomes present in various human body fluids. With this study, we aim to reveal the nature of urinary-exosomal miR-2909 & miR-615-3p recruitment in patients suffering from either prostate cancer (n=90) or bladder cancer (n=60) as compared to that in either prostate disease-control subjects having benign prostate hyperplasia (n=10) or healthy subjects (n=50)...
July 29, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28748478/urine-exosome-isolation-and-characterization
#5
Jonathan M Street, Erik H Koritzinsky, Deonna M Glispie, Peter S T Yuen
Exosomes are nanometer-scale, membrane-enclosed vesicles that can potentially be used to detect nephrotoxicity, and reveal the subsequent response of the kidney. Epithelial cells of every nephron segment can contribute to the urinary exosome population, which is rich in potential biomarkers, including membrane proteins such as transporters and receptors, transcription factors, and microRNAs. These exosomal biomarkers may be up- or downregulated upon nephrotoxicant exposure. Exosome isolation is an area of ongoing research...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28719236/applying-an-artificial-neural-network-model-for-developing-a-severity-score-for-patients-with-hereditary-amyloid-polyneuropathy
#6
Shenia Novis, Felipe Machado, Victor B Costa, Debora Foguel, Marcia W Cruz, José Manoel de Seixas
Hereditary (familial) amyloid polyneuropathy (FAP) is a systemic disease that includes a sensorimotor polyneuropathy related to transthyretin (TTR) mutations. So far, a scale designed to classify the severity of this disease has not yet been validated. This work proposes the implementation of an artificial neural network (ANN) in order to develop a severity scale for monitoring the disease progression in FAP patients. In order to achieve this goal, relevant symptoms and laboratory findings were collected from 98 Brazilian patients included in THAOS - the Transthyretin Amyloidosis Outcomes Survey...
July 18, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28717136/association-of-plasma-and-urinary-mutant-dna-with-clinical-outcomes-in-muscle-invasive-bladder-cancer
#7
K M Patel, K E van der Vos, C G Smith, F Mouliere, D Tsui, J Morris, D Chandrananda, F Marass, D van den Broek, D E Neal, V J Gnanapragasam, T Forshew, B W van Rhijn, C E Massie, N Rosenfeld, M S van der Heijden
Muscle Invasive Bladder Cancer (MIBC) has a poor prognosis. Whilst patients can achieve a 6% improvement in overall survival with Neo-Adjuvant Chemotherapy (NAC), many do not respond. Body fluid mutant DNA (mutDNA) may allow non-invasive identification of treatment failure. We collected 248 liquid biopsy samples including plasma, cell pellet (UCP) and supernatant (USN) from spun urine, from 17 patients undergoing NAC. We assessed single nucleotide variants and copy number alterations in mutDNA using Tagged-Amplicon- and shallow Whole Genome- Sequencing...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28675676/polyclonal-regulatory-t-cell-therapy-for-control-of-inflammation-in-kidney-transplants
#8
S Chandran, Q Tang, M Sarwal, Z G Laszik, A L Putnam, K Lee, J Leung, V Nguyen, T Sigdel, E C Tavares, J Y C Yang, M Hellerstein, M Fitch, J A Bluestone, F Vincenti
Early subclinical inflammation in kidney transplants is associated with later graft fibrosis and dysfunction. Regulatory T cells (Tregs) can reverse established inflammation in animal models. We conducted a pilot safety and feasibility trial of autologous Treg cell therapy in three kidney transplant recipients with subclinical inflammation noted on 6-month surveillance biopsies. Tregs were purified from peripheral blood and polyclonally expanded ex vivo using medium containing deuterated glucose to label the cells...
July 4, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28670865/robotic-radical-perineal-cystectomy-and-extended-pelvic-lymphadenectomy-initial-investigation-using-a-purpose-built-single-port-robotic-system
#9
Matthew J Maurice, Jeremy Reese, Jihad H Kaouk
OBJECTIVES: To assess the feasibility of perineal radical cystoprostatectomy using the latest generation purpose-built single-port robotic surgical system. MATERIALS AND METHODS: In two male cadavers, the da Vinci SP1098 Surgical System was used to perform radical cystoprostatectomy and bilateral extended pelvic lymphadenectomy. New features in this model include enhanced high-definition three-dimensional optics, improved instrument maneuverability, and a real-time instrument tracking and guideance system...
July 3, 2017: BJU International
https://www.readbyqxmd.com/read/28668578/computer-assisted-three-dimensional-tracking-of-sensory-innervation-in-the-murine-bladder-mucosa-with-two-photon-microscopy
#10
Anna Schueth, Bart Spronck, Marc A M J van Zandvoort, Gommert A van Koeveringe
A strong association between functional bladder disorders and bladder sensation is well-known, with a relationship between malfunctioning detrusor muscle and abnormal sensation arising from the sub-urothelium and the lamina propria (LP), has been suggested. However, the exact underlying pathophysiology of these bladder disorders is not completely understood. Therefore, it is important to gain knowledge on sensory innervation of the urinary bladder in order to understand the neural network function in healthy and diseased bladder...
June 28, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28658293/green-design-of-a-paper-test-card-for-urinary-iodine-analysis
#11
Nicholas M Myers, Ivan C Leung, Sean W McGee, Kathleen Eggleson, Marya Lieberman
When young children do not receive adequate amounts of the micronutrient iodine in their diet, their growth and cognitive development can be impaired. Nearly every country in the world has programs in place to track iodine intake and provide supplemental iodine if needed, usually in the form of fortified salt. The iodine nutrition status of a population can be tracked by monitoring iodine levels in urine samples to see if the median value falls in the range of 100-300 micrograms of iodine per liter of urine (μg I/L), which indicates adequate or more than adequate iodine nutrition...
2017: PloS One
https://www.readbyqxmd.com/read/28646909/the-morphological-regeneration-and-functional-restoration-of-bladder-defects-by-a-novel-scaffold-and-adipose-derived-stem-cells-in-a-rat-augmentation-model
#12
Qiong Wang, Dong-Dong Xiao, Hao Yan, Yang Zhao, Shi Fu, Juan Zhou, Zhong Wang, Zhe Zhou, Ming Zhang, Mu-Jun Lu
BACKGROUND: Due to the multilineage differentiation ability and paracrine role of adipose-derived stem cells (ASCs) for bladder defect repair, various scaffolds have been applied in combination with ASCs to promote bladder regeneration and restore bladder function. However, the low survival rate of ASCs and the difficulty of promoting bladder functional recovery are still unsolved. To explore these problems, we investigated the feasibility of a novel scaffold seeded with ASCs in a rat model of bladder augmentation...
June 24, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28628622/urinary-catheter-associated-microbiota-change-in-accordance-with-treatment-and-infection-status
#13
Laetitia Bossa, Kimberly Kline, Diane McDougald, Bonsan Bonne Lee, Scott A Rice
The use of long-term catheterisation to manage insensate bladders, often associated with spinal cord injury (SCI), increases the risk of microbial colonisation and infection of the urinary tract. Urinary tract infection (UTI) is typically diagnosed and treated based on the culturing of organisms from the urine, although this approach overlooks low titer, slow growing and non-traditional pathogens. Here, we present an investigation of the urinary tract microbiome in catheterised SCI individuals, using T-RFLP and metagenomic sequencing of the microbial community...
2017: PloS One
https://www.readbyqxmd.com/read/28587844/postoperative-management-of-radical-cystectomy-review-of-the-evidence-on-the-prevention-and-treatment-of-urological-complications
#14
O Rodríguez Faba, R Parada Moreno, L Malca, A Palomino Martínez, N Nervo, A Breda, C Esquinas, J Palou
INTRODUCTION AND OBJECTIVES: This review article focuses on the prevention and management of the most common postoperative urological complications of radical cystectomy. We reviewed the current literature and conducted an analysis of frequency, prevention and treatment of complications. ACQUISITION OF EVIDENCE: We conducted a search on Medline to identify original articles, literature reviews and editorials focusing on the urological complications of radical cystectomy during the first 90 days after surgery...
June 3, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28540122/presurgical-role-of-mri-tractography-in-a-case-of-extensive-cervicothoracic-spinal-ependymoma
#15
Francesca Granata, Sergio Racchiusa, Enricomaria Mormina, Valeria Barresi, Giada Garufi, Giovanni Grasso, Francesco Maria Salpietro, Marcello Longo, Concetta Alafaci
BACKGROUND: Intramedullary spinal ependymoma is a tumor, hardly characterizable with conventional magnetic resonance (MR) imaging only. MR diffusion tensor imaging (DTI) with three-dimensional fiber-tracking reconstructions allows the evaluation of the relationship between neoplasm and white matter fiber tracts, being a powerful tool in presurgical planning. We present DTI findings in a case of a young female with an extensive cervicothoracic spinal ependymoma. CASE DESCRIPTION: The patient complained of a 2-month history of acute urinary retention, weakness and numbness on the lower limbs and the upper left limb...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28520506/urinary-nanovesicles-captured-by-lectins-or-antibodies-demonstrate-variations-in-size-and-surface-glycosylation-profile
#16
Jared Q Gerlach, Ciaran M Maguire, Anja Krüger, Lokesh Joshi, Adriele Prina-Mello, Matthew D Griffin
AIM: The use of carbohydrate-binding proteins (lectins) to isolate urinary extracellular vesicles (uEVs) was investigated and the captured subpopulations were characterized. METHODS: Pooled uEVs from multiple healthy donors were exposed to lectin-conjugated or antibody-conjugated beads. Recovered uEVs were evaluated by protein estimation, transmission electron microscopy, nanoparticle tracking analysis and lectin microarray profiling. RESULTS: uEVs isolated by lectin- and antibody-based affinity capture exhibited distinct variations in size and surface content...
May 18, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28490038/pediatric-sleep-disordered-breathing-an-update-on-diagnostic-testing
#17
Brian McGrath, Jerrold Lerman
PURPOSE OF REVIEW: Recent advances in diagnostic testing for obstructive sleep apnea in children have refined the standard tests while identifying several new tools that hold promise to radically change how we diagnose sleep apnea. RECENT FINDINGS: Studies have demonstrated that the polysomnogram may be modified to permit home assessment of sleep disturbed breathing in children to ensure more widespread access to the test. Alternately, questionnaires, nocturnal oximetry, and diagnostic urinary biomarkers have shown great promise as both sensitive and specific tools to diagnose sleep apnea in children as well as track the severity of the disease...
June 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28415542/bladder-smooth-muscle-cells-on-electrospun-poly-%C3%AE%C2%B5-caprolactone-poly-l-lactic-acid-scaffold-promote-bladder-regeneration-in-a-canine-model
#18
Nasser Shakhssalim, Masoud Soleimani, Mohammad M Dehghan, Javad Rasouli, Masoud Taghizadeh-Jahed, Peyman M Torbati, Mohammad Naji
Engineering of urinary bladder has been the focus of numerous studies in recent decade. Novel biomaterials, innovative fabrication methods and various modification processes of scaffolds are the critical issues to find supportive matrices. Supportive characteristics of electrospun PCL/PLLA nano-scaffold for bladder augmentation in canine model and the role of bladder cells in regeneration process were appraised. Electrospun PCL/PLLA was fabricated by co-electrospinning of PCL and PLLA. Bladder cells were isolated and transduced with lentiviral particles encoding eGFP and JRed proteins...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412047/patient-reported-quality-of-life-after-proton-beam-therapy-for-prostate-cancer-the-effect-of%C3%A2-prostate-size
#19
Anuj Goenka, Neil B Newman, Hiral Fontanilla, Oren Cahlon, Brian Chon, Henry Tsai, Eugen Hug, Carl Brown, Carlos Vargas, Rahul R Parikh
BACKGROUND: In the present study, we assessed the effect of prostate gland size on patient-assessed genitourinary and gastrointestinal (GI) quality of life (QOL) after definitive treatment of prostate adenocarcinoma with proton beam therapy. PATIENTS AND METHODS: As a part of a prospective outcome tracking protocol, 81 patients treated at a single center between with proton beam therapy completed the Expanded Prostate Cancer Index Composite (EPIC) questionnaire before treatment and at the follow-up examinations...
March 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28406764/the-efficacy-of-tocilizumab-for-the-treatment-of-chinese-takayasu-s-arteritis
#20
Jiaxin Zhou, Zhe Chen, Jing Li, Yunjiao Yang, Jiuliang Zhao, Hu Chen, Min Liu, Fei Sun, Mengtao Li, Xinping Tian, Xiaofeng Zeng
OBJECTIVES: The aim of this study was to evaluate the efficacy and safety of tocilizumab (TCZ) in Chinese Takayasu's arteritis (TAK) patients. METHODS: This was a single-centre prospective study. Sixteen consecutive TAK patients were included. Patients were treated with tocilizumab infusions with a dosage of 8 mg/kg. Serum inflammation markers including erythrocyte sedimentation rate (ESR) and hypersensitivity C-reactive protein (hsCRP) were recorded at baseline and before each TCZ infusion...
March 2017: Clinical and Experimental Rheumatology
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