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https://www.readbyqxmd.com/read/29674052/glycan-affinity-magnetic-nanoplatforms-for-urinary-glycobiomarkers-discovery-in-bladder-cancer
#1
Rita Azevedo, Janine Soares, Cristiana Gaiteiro, Andreia Peixoto, Luís Lima, Dylan Ferreira, Marta Relvas-Santos, Elisabete Fernandes, Ana Tavares, Sofia Cotton, Ana Luísa Daniel-da-Silva, Lúcio Lara Santos, Rui Vitorino, Francisco Amado, José Alexandre Ferreira
Bladder Cancer (BC) presents one of the highest recurrence rates amongst solid tumours and constitutes the second deadliest disease of the genitourinary track. Non-invasive identification of patients facing disease recurrence and/or progression remains one of the most critical and challenging aspects in disease management. To contribute to this goal, we demonstrate the potential of glycan-affinity glycoproteomics nanoplatforms for urinary biomarkers discovery in bladder cancer. Briefly, magnetic nanoprobes (MNP) coated with three broad-spectrum lectins, namely Concanavalin A (ConA; MNP@ConA), Wheat Germ Agglutinin (WGA; MNP@WGA), and Sambucus nigra (SNA; MNP@SNA), were used to selectively capture glycoproteins from the urine of low-grade and high-grade non-muscle invasive as well as muscle-invasive BC patients...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29626685/discrepancy-between-neurosurgery-morbidity-and-mortality-conference-discussions-and-hospital-quality-metric-standards
#2
Lauren E Rotman, Matthew C Davis, Arsalaan A Salehani, Devin R Broadwater, Nathaniel H Reeve, Kristen O Riley
OBJECTIVE: Medical institutions use quality metrics to track complications seen in hospital admissions. Similarly, morbidity and mortality (M&M) conferences are held to peer review complications. The purpose of this study was to compare the complications identified in a cohort of patients within 30 days of neurosurgical intervention with those captured in a cohort of M&M conferences. METHODS: All complications that occurred within 30 days of surgery were obtained for patients admitted to the neurosurgical service between May and September 2013...
April 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29606358/incontinence-affects-health-related-quality-of-life-in-children-and-adolescents-with-spina-bifida
#3
Konrad M Szymanski, Mark P Cain, Benjamin Whittam, Martin Kaefer, Richard C Rink, Rosalia Misseri
PURPOSE: Despite devoting many resources to managing urinary and fecal incontinence (UI and FI) in children with spina bifida (SB), it remains unclear whether either is associated with lower health-related quality of life (HRQOL). We sought to determine the impact of UI and FI on HRQOL in this population. MATERIALS AND METHODS: Children with SB (8-17 years) living in the United States were surveyed online and in SB clinics (2013-15). We evaluated incontinence over the previous 4 weeks using a UI dry interval (<4 h, ≥4 h), FI clean interval (<1 week, ≥ 1 week), and self-reported amount of UI and FI (for each: a lot, medium, a little, none)...
March 21, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29573022/exploration-of-male-urethral-sphincter-complex-using-diffusion-tensor-imaging-dti-based-fiber-tracking
#4
Shantanu Sinha, Usha Sinha, Vadim Malis, Valmik Bhargava, Kyoko Sakamoto, Mahadevan Rajasekaran
BACKGROUND: Urinary incontinence is a major clinical problem arising primarily from age-related degenerative changes to the sphincter muscles. However, the precise anatomy of the normal male sphincter muscles has yet to be established. Diffusion tensor imaging (DTI) may offer a unique insight into muscle microstructure and fiber architecture. PURPOSE: To explore the anatomy of the urethral sphincter muscles pertinent to urinary continence function using DT-MRI. STUDY TYPE: Prospective cohort study...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29572871/a-preliminary-origin-tracking-study-of-different-densities-urinary-exosomes
#5
Tao Lan, Xingjun Xi, Qiao Chu, Liang Zhao, Apeng Chen, Joann J Lu, Fenghe Wang, Weibing Zhang
Based on density differences of different subpopulations of exosomes, two kinds of micro-vesicles with different densities were captured from urine by a modified sucrose density gradient ultracentrifuge separation method. Verified by transmission electron microscope (TEM) and western blot, the results showed these two kinds of micro-vesicles were all exosomes. And these two kinds of exosomes were analyzed by TEM, two dimensional electrophoresis (2DE) and capillary zone electrophoresis (CZE), respectively. The results of TEM showed these two exosomes with different densities have different morphological characteristics, and some tiny proteomic differences were shown in the results of 2DE of these two exosomes...
March 23, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29551948/application-of-fast-track-surgery-in-routine-nursing-for-patient-with-colorectal-cancer
#6
Yongrui Liu
Objective : To investigate the clinical effect of fast track surgery (FTS) in perioperative nursing of colorectal cancer surgery. Background : In recent years, many complicated surgery began to develop in the direction of low invasion and short hospital time, which provides an unprecedented opportunity for the development of fast track surgery (FTS). Methods : According to different nursing measures, 156 cases of colorectal cancer patients treated in our hospital were divided into FTS nursing group (86 cases) and traditional nursing group (70 cases)...
December 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29531537/injected-human-muscle-precursor-cells-overexpressing-pgc-1-%C3%AE-enhance-functional-muscle-regeneration-after-trauma
#7
Deana Haralampieva, Souzan Salemi, Thomas Betzel, Ivana Dinulovic, Stefanie D Krämer, Roger Schibli, Tullio Sulser, Christoph Handschin, Simon M Ametamey, Daniel Eberli
While many groups demonstrated new muscle tissue formation after muscle precursor cell (MPC) injection, the capacity of these cells to heal muscle damage, for example, sphincter in stress urinary incontinence, in long-term is still limited. Therefore, the first goal of our project was to optimize the functional regenerative potential of hMPC by genetic modification to overexpress human peroxisome proliferator-activated receptor gamma coactivator 1-alpha (hPGC-1 α ), key regulator of exercise-mediated adaptation...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29516133/combined-untargeted-and-targeted-fingerprinting-by-comprehensive-two-dimensional-gas-chromatography-revealing-fructose-induced-changes-in-mice-urinary-metabolic-signatures
#8
Davide Bressanello, Erica Liberto, Massimo Collino, Fausto Chiazza, Raffaella Mastrocola, Stephen E Reichenbach, Carlo Bicchi, Chiara Cordero
This study exploits the information potential of comprehensive two-dimensional gas chromatography configured with a parallel dual secondary column-dual detection by mass spectrometry and flame ionization (GC×2GC-MS/FID) to study changes in urinary metabolic signatures of mice subjected to high-fructose diets. Samples are taken from mice fed with normal or fructose-enriched diets provided either in aqueous solution or in solid form and analyzed at three stages of the dietary intervention (1, 6, and 12 weeks)...
March 7, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29479093/development-validity-and-reliability-of-an-urdu-version-of-the-international-prostate-symptom-score
#9
Zeeshan Arshad, Syed Zafar Zaidi, Anila Jamshaid
OBJECTIVE: To develop and validate the Urdu version of the International Prostate Symptoms Score. METHODS: The prospective study was conducted at Indus Hospital, Karachi, from January to April 2014, and comprised interviews of subjects at baseline and at 2 weeks for assessing the test-retest reliability. Patients presenting with lower urinary track symptoms and who were able to read Urdu were recruited as subjects. The reliability of the Urdu version of the International Prostate Symptoms Score was assessed by determining the internal consistency, and by assessing the test-retest reliability...
February 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29478758/the-national-healthcare-safety-network-long-term-care-facility-component-early-reporting-experience-january-2013-december-2015
#10
Danielle L Palms, Elisabeth Mungai, Taniece Eure, Angela Anttila, Nicola D Thompson, Margaret A Dudeck, Jonathan R Edwards, Jeneita M Bell, Nimalie D Stone
BACKGROUND: In 2012, the Centers for Disease Control and Prevention launched the Long-term Care Facility (LTCF) Component of the National Healthcare Safety Network (NHSN) designed for LTCFs to monitor Clostridium difficile infections (CDIs), urinary tract infections (UTIs), infections due to multidrug-resistant organisms, including methicillin-resistant Staphylococcus aureus (MRSA), and infection prevention process measures. METHODS: We describe characteristics and reporting patterns of facilities enrolled in the first 3 years of the surveillance system and rate estimates for CDI, UTI, and MRSA data submitted between 2013 and 2015...
February 22, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29453992/serum-cystatin-c-level-is-associated-with-carotid-arterial-wall-elasticity-in-subjects-with-type-2-diabetes-mellitus-a-potential-marker-of-early-stage-atherosclerosis
#11
Rei Kaneko, Shojiro Sawada, Ai Tokita, Rieko Honkura, Noriko Tumura, Shinjiro Kodama, Tomohito Izumi, Kei Takahashi, Kenji Uno, Junta Imai, Tetsuya Yamada, Yukiya Miyachi, Hideyuki Hasegawa, Hiroshi Kanai, Yasushi Ishgaki, Hideki Katagiri
AIMS: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. METHODS: This cross-sectional study enrolled 180 T2DM patients, who were classified as not having atherosclerosis according to the carotid intima-media thickness (IMT) criteria...
February 14, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29427523/meropenem-and-vaborbactam-stepping-up-the-battle-against-carbapenem-resistant-enterobacteriaceae
#12
Sarah Christina Jane Jorgensen, Michael Joseph Rybak
Vaborbactam (VAB; formerly RPX7009) is a novel beta-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Ambler class A and C beta-lactamases. It has been co-formulated with meropenem to restore its activity against Klebsiella pneumoniae carbapenemases (KPC). VAB does not inhibit class B or D carbapenemases, nor does it improve the activity of meropenem against multidrug-resistant non-fermenting Gram-negative bacilli, notably Acinetobacter spp. and Pseudomonas aeruginosa...
February 10, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29425839/a-prospective-study-of-the-natural-history-of-urinary-incontinence-in-women
#13
Kaitlin A Hagan, Elisabeth Erekson, Andrea Austin, Vatche A Minassian, Mary K Townsend, Julie Pw Bynum, Francine Grodstein
BACKGROUND: Symptoms of urinary incontinence are commonly perceived to vary over time; yet, there is limited quantitative evidence regarding the natural history of urinary incontinence, especially over the long-term. OBJECTIVE: To delineate the course of urinary incontinence symptoms over time, using two large cohorts of middle-age and older women, with data collected over 10 years. STUDY DESIGN: We studied 9,376 women from the Nurses' Health Study, age 56-81 years at baseline, and 7,491 women from Nurses' Health Study II, age 39-56 years, with incident urinary incontinence in 2002-3...
February 6, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29417352/urokin-a-software-to-enhance-our-understanding-of-urogenital-motion
#14
Catriona S Czyrnyj, Michel R Labrosse, Ryan B Graham, Linda McLean
Transperineal ultrasound (TPUS) allows for objective quantification of mid-sagittal urogenital mechanics, yet current practice omits dynamic motion information in favor of analyzing only a rest and a peak motion frame. This work details the development of UROKIN, a semi-automated software which calculates kinematic curves of urogenital landmark motion. A proof of concept analysis, performed using UROKIN on TPUS video recorded from 20 women with and 10 women without stress urinary incontinence (SUI) performing maximum voluntary contraction of the pelvic floor muscles...
February 7, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29374286/evidence-of-cross-regulation-in-two-closely-related-pyruvate-sensing-systems-in-uropathogenic-escherichia-coli
#15
Bradley D Steiner, Allison R Eberly, Melanie N Hurst, Ellisa W Zhang, Hamilton D Green, Stefan Behr, Kirsten Jung, Maria Hadjifrangiskou
Two-component systems (TCSs) dictate many bacterial responses to environmental change via the activation of a membrane-embedded sensor kinase, which has molecular specificity for a cognate response regulator protein. However, although the majority of TCSs operate through seemingly strict cognate protein-protein interactions, there have been several reports of TCSs that violate this classical model of signal transduction. Our group has recently demonstrated that some of these cross-interacting TCSs function in a manner that imparts a fitness advantage to bacterial pathogens...
February 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29351556/testosterone-induced-benign-prostatic-hyperplasia-rat-and-dog-as-facile-models-to-assess-drugs-targeting-lower-urinary-tract-symptoms
#16
Jing Li, Yanxin Tian, Shimeng Guo, Haifeng Gu, Qianting Yuan, Xin Xie
Benign prostatic hyperplasia (BPH) is an age-related disease, affecting a majority of elderly men worldwide. Medical management of BPH is an alternative to surgical treatment of this disease. Currently, α1-adrenergic receptor (α1-AR) antagonists are among the first line drugs to treat BPH by reducing the tension of urinary track and thus the obstructive symptoms in voiding. In drug development, old male dogs with spontaneous BPH are considered the golden standard of the animal models. However, old dogs (>6 years) are expensive and not all old dogs develop BPH...
2018: PloS One
https://www.readbyqxmd.com/read/29306574/incidence-and-risk-factors-of-postoperative-urinary-retention-and-bladder-catheterization-in-patients-undergoing-fast-track-total-joint-arthroplasty-a-prospective-observational-study-on-371-patients
#17
Ruben Scholten, Keetie Kremers, Sebastiaan A W van de Groes, Diederik M Somford, Sander Koëter
BACKGROUND: Postoperative urinary retention (POUR) appears to be a common complication in lower limb joint arthroplasty; however, reports on its incidence vary. There is no general consensus on its definition and there is no scientific evidence on treatment principles. We performed a prospective observational study to establish the incidence of POUR and its risk factors, including the preoperative postvoid residual urine volume and the perioperative fluid balance, in fast-track total joint arthroplasty (TJA)...
December 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29235431/using-targeted-solution-tools-as-an-initiative-to-improve-hand-hygiene-challenges-and-lessons-learned
#18
J A Al-Tawfiq, M Treble, R Abdrabalnabi, C Okeahialam, S Khazindar, S Myers
The Joint Commission Centre for Transforming Healthcare's Web-based Targeted Solutions Tool (TST) for improving hand hygiene was implemented to elucidate contributing factors to low compliance rates of hand hygiene. Monitoring of compliance was done by trained unknown and known observers and rates of hospital-acquired infections were tracked and correlated against the changes in hand hygiene compliance. In total, 5669 of hand hygiene observations were recorded by the secret observers. The compliance rate increased from 75·4% at baseline (May-August 2014) to 88·6% during the intervention (13 months) and the control periods (P < 0·0001)...
January 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29205689/ultrasound-findings-and-associated-factors-to-morbidity-in-schistosoma-haematobium-infection-in-a-highly-endemic-setting
#19
Cristina Bocanegra García, Zeferino Pintar, Xavier Serres, Jacobo Mendioroz, Milagros Moreno, Sara Gallego, Teresa López, Antoni Soriano-Arandes, Maria Luisa Aznar, Nicolau Sikaleta, Eva Gil, Fernando Salvador, Israel Molina
OBJECTIVE: To evaluate the usefulness of the WHO classification of ultrasound pathological changes and to establish risk factors for morbidity in a highly endemic setting. METHODS: One hundred and fifty-seven ultrasounds were performed on school-aged children previously diagnosed with urinary schistosomiasis in Cubal, Angola. The findings were analysed according to the WHO guidelines. Factors for morbidity were studied. RESULTS: Mean age of the children was 8...
February 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29175999/modern-fertility-awareness-methods-wrist-wearables-capture-the-changes-of-temperature-associated-with-the-menstrual-cycle
#20
Mohaned Shilaih, Brianna M Goodale, Lisa Falco, Florian Kübler, Valerie De Clerck, Brigitte Leeners
Core and peripheral body temperatures are affected by changes in reproductive hormones during the menstrual cycle. Women worldwide use the basal body temperature (BBT) method to aid and prevent conception. However, prior research suggests taking one's daily temperature can prove inconvenient and subject to environmental factors. We investigate whether a more automatic, non-invasive temperature measurement system can detect changes in temperature across the menstrual cycle. We examined how wrist-skin temperature (WST), measured with wearable sensors, correlates with urinary tests of ovulation and may serve as a new method of fertility tracking...
November 24, 2017: Bioscience Reports
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