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https://www.readbyqxmd.com/read/29453992/serum-cystatin-c-level-is-associated-with-carotid-arterial-wall-elasticity-in-subjects-with-type-2-diabetes-mellitus-a-potential-marker-of-early-stage-atherosclerosis
#1
Rei Kaneko, Shojiro Sawada, Ai Tokita, Rieko Honkura, Noriko Tumura, Shinjiro Kodama, Tomohito Izumi, Kei Takahashi, Kenji Uno, Junta Imai, Tetsuya Yamada, Yukiya Miyachi, Hideyuki Hasegawa, Hiroshi Kanai, Yasushi Ishgaki, Hideki Katagiri
AIMS: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. METHODS: This cross-sectional study enrolled 180 T2DM patients, who were classified as not having atherosclerosis according to the carotid intima-media thickness (IMT) criteria...
February 14, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29427523/meropenem-and-vaborbactam-stepping-up-the-battle-against-carbapenem-resistant-enterobacteriaceae
#2
Sarah Christina Jane Jorgensen, Michael Joseph Rybak
Vaborbactam (VAB; formerly RPX7009) is a novel beta-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Ambler class A and C beta-lactamases. It has been co-formulated with meropenem to restore its activity against Klebsiella pneumoniae carbapenemases (KPC). VAB does not inhibit class B or D carbapenemases, nor does it improve the activity of meropenem against multidrug-resistant non-fermenting Gram-negative bacilli, notably Acinetobacter spp. and Pseudomonas aeruginosa...
February 10, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29425839/a-prospective-study-of-the-natural-history-of-urinary-incontinence-in-women
#3
Kaitlin A Hagan, Elisabeth Erekson, Andrea Austin, Vatche A Minassian, Mary K Townsend, Julie Pw Bynum, Francine Grodstein
BACKGROUND: Symptoms of urinary incontinence are commonly perceived to vary over time; yet, there is limited quantitative evidence regarding the natural history of urinary incontinence, especially over the long-term. OBJECTIVE: To delineate the course of urinary incontinence symptoms over time, using two large cohorts of middle-age and older women, with data collected over 10 years. STUDY DESIGN: We studied 9,376 women from the Nurses' Health Study, age 56-81 years at baseline, and 7,491 women from Nurses' Health Study II, age 39-56 years, with incident urinary incontinence in 2002-3...
February 6, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29417352/urokin-a-software-to-enhance-our-understanding-of-urogenital-motion
#4
Catriona S Czyrnyj, Michel R Labrosse, Ryan B Graham, Linda McLean
Transperineal ultrasound (TPUS) allows for objective quantification of mid-sagittal urogenital mechanics, yet current practice omits dynamic motion information in favor of analyzing only a rest and a peak motion frame. This work details the development of UROKIN, a semi-automated software which calculates kinematic curves of urogenital landmark motion. A proof of concept analysis, performed using UROKIN on TPUS video recorded from 20 women with and 10 women without stress urinary incontinence (SUI) performing maximum voluntary contraction of the pelvic floor muscles...
February 7, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29374286/evidence-of-cross-regulation-in-two-closely-related-pyruvate-sensing-systems-in-uropathogenic-escherichia-coli
#5
Bradley D Steiner, Allison R Eberly, Melanie N Hurst, Ellisa W Zhang, Hamilton D Green, Stefan Behr, Kirsten Jung, Maria Hadjifrangiskou
Two-component systems (TCSs) dictate many bacterial responses to environmental change via the activation of a membrane-embedded sensor kinase, which has molecular specificity for a cognate response regulator protein. However, although the majority of TCSs operate through seemingly strict cognate protein-protein interactions, there have been several reports of TCSs that violate this classical model of signal transduction. Our group has recently demonstrated that some of these cross-interacting TCSs function in a manner that imparts a fitness advantage to bacterial pathogens...
January 27, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29351556/testosterone-induced-benign-prostatic-hyperplasia-rat-and-dog-as-facile-models-to-assess-drugs-targeting-lower-urinary-tract-symptoms
#6
Jing Li, Yanxin Tian, Shimeng Guo, Haifeng Gu, Qianting Yuan, Xin Xie
Benign prostatic hyperplasia (BPH) is an age-related disease, affecting a majority of elderly men worldwide. Medical management of BPH is an alternative to surgical treatment of this disease. Currently, α1-adrenergic receptor (α1-AR) antagonists are among the first line drugs to treat BPH by reducing the tension of urinary track and thus the obstructive symptoms in voiding. In drug development, old male dogs with spontaneous BPH are considered the golden standard of the animal models. However, old dogs (>6 years) are expensive and not all old dogs develop BPH...
2018: PloS One
https://www.readbyqxmd.com/read/29306574/incidence-and-risk-factors-of-postoperative-urinary-retention-and-bladder-catheterization-in-patients-undergoing-fast-track-total-joint-arthroplasty-a-prospective-observational-study-on-371-patients
#7
Ruben Scholten, Keetie Kremers, Sebastiaan A W van de Groes, Diederik M Somford, Sander Koëter
BACKGROUND: Postoperative urinary retention (POUR) appears to be a common complication in lower limb joint arthroplasty; however, reports on its incidence vary. There is no general consensus on its definition and there is no scientific evidence on treatment principles. We performed a prospective observational study to establish the incidence of POUR and its risk factors, including the preoperative postvoid residual urine volume and the perioperative fluid balance, in fast-track total joint arthroplasty (TJA)...
December 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29235431/using-targeted-solution-tools-as-an-initiative-to-improve-hand-hygiene-challenges-and-lessons-learned
#8
J A Al-Tawfiq, M Treble, R Abdrabalnabi, C Okeahialam, S Khazindar, S Myers
The Joint Commission Centre for Transforming Healthcare's Web-based Targeted Solutions Tool (TST) for improving hand hygiene was implemented to elucidate contributing factors to low compliance rates of hand hygiene. Monitoring of compliance was done by trained unknown and known observers and rates of hospital-acquired infections were tracked and correlated against the changes in hand hygiene compliance. In total, 5669 of hand hygiene observations were recorded by the secret observers. The compliance rate increased from 75·4% at baseline (May-August 2014) to 88·6% during the intervention (13 months) and the control periods (P < 0·0001)...
December 13, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29205689/ultrasound-findings-and-associated-factors-to-morbidity-in-schistosoma-haematobium-infection-in-a-highly-endemic-setting
#9
Cristina Bocanegra García, Zeferino Pintar, Xavier Serres, Jacobo Mendioroz, Milagros Moreno, Sara Gallego, Teresa López, Antoni Soriano-Arandes, Maria Luisa Aznar, Nicolau Sikaleta, Eva Gil, Fernando Salvador, Israel Molina
OBJECTIVE: To evaluate the usefulness of the WHO classification of ultrasound pathological changes and to establish risk factors for morbidity in a highly endemic setting. METHODS: 157 ultrasounds were performed on school-aged children previously diagnosed with urinary schistosomiasis in Cubal, Angola. The findings were analysed according to WHO guidelines. Factors for morbidity were studied. RESULTS: Mean age of the children was 8.7 (SD 3...
December 4, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29175999/modern-fertility-awareness-methods-wrist-wearables-capture-the-changes-of-temperature-associated-with-the-menstrual-cycle
#10
Mohaned Shilaih, Brianna M Goodale, Lisa Falco, Florian Kübler, Valerie De Clerck, Brigitte Leeners
Core and peripheral body temperatures are affected by changes in reproductive hormones during the menstrual cycle. Women worldwide use the basal body temperature (BBT) method to aid and prevent conception. However, prior research suggests taking one's daily temperature can prove inconvenient and subject to environmental factors. We investigate whether a more automatic, non-invasive temperature measurement system can detect changes in temperature across the menstrual cycle. We examined how wrist-skin temperature (WST), measured with wearable sensors, correlates with urinary tests of ovulation and may serve as a new method of fertility tracking...
November 24, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29168209/subclinical-left-ventricular-systolic-dysfunction-detected-by-two-dimensional-speckle-tracking-echocardiography-in-patients-with-pheochromocytoma-and-paraganglioma-and-preserved-ejection-fraction
#11
Li Ding, Wen Ling Zhu, Zheng Pei Zeng, Han Zhong Li, Jin Ji, Li Gang Fang, Jing Ping Sun
BACKGROUND: Excessive catecholamine leads to pressure overload and left ventricular (LV) remodeling. The goal of this study was to explore subclinical LV systolic dysfunction and the mechanism of preserved left ventricular ejection fraction (LVEF) in patients with pheochromocytoma and paraganglioma using two-dimensional speckle tracking echocardiography. METHODS: A total of 48 patients with pheochromocytoma and paraganglioma and preserved LVEF and 38 age- and gender-matched volunteers were studied...
November 22, 2017: Echocardiography
https://www.readbyqxmd.com/read/29160004/urological-dysfunction-in-young-women-an-inheritance-of-childhood
#12
Elisabetta Costantini, Ester Illiano, Konstantinos Giannitsas, Marco Prestipino, Antonio Luigi Pastore, Antonio Carbone, Giovanni Palleschi, Raffaele Balsamo, Franca Natale, Donata Villari, Vittorio Bini, Serena Maruccia, Maria-Teresa Filocamo, Alessandro Zucchi
OBJECTIVE: To investigate the correlation of a history of lower urinary tract symptomatology during childhood with lower urinary tract dysfunction in young adult women. SUBJECTS AND METHODS: This was a multicentre, prospective, case-control study conducted between April 2013 and November 2015. A total of 300 women, aged 18-40 years, participated. The case group comprised women attending urogynaecology clinics for various lower urinary tract complaints and the control group was recruited from a healthy population...
November 21, 2017: BJU International
https://www.readbyqxmd.com/read/29158174/impact-of-cystectomy-with-urinary-diversion-upon-tracked-receipt-of-opioid-prescriptions-among-patients-with-interstitial-cystitis-bladder-pain-syndrome
#13
David S Koslov, Fernandino Vilson, Marc Colaco, Ryan P Terlecki, Robert J Evans
OBJECTIVES: To compare opioid requirements before and after cystectomy for end stage Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) using a statewide tracking system. METHODS: Narcotic prescriptions were captured using the North Carolina Controlled Substance Reporting System for patients at a single institute undergoing cystectomy with urinary diversion (CWUD) for refractory, end stage IC/BPS between 2010-2017. Values were documented for the year before and the year after surgery (excluding 30 days postoperatively to account for surgical pain) and converted to Morphine Equivalents (ME)...
November 17, 2017: Urology
https://www.readbyqxmd.com/read/29101422/biomarkers-of-inflammation-and-endothelial-dysfunction-as-predictors-of-pulse-pressure-and-incident-hypertension-in-type-1-diabetes-a-20%C3%A2-year-life-course-study-in-an-inception-cohort
#14
Isabel Ferreira, Peter Hovind, Casper G Schalkwijk, Hans-Henrik Parving, Coen D A Stehouwer, Peter Rossing
AIMS/HYPOTHESIS: Vascular inflammation and endothelial dysfunction are thought to contribute to arterial stiffening and hypertension. This study aims to test this hypothesis with longitudinal data in the context of type 1 diabetes. METHODS: We investigated, in an inception cohort of 277 individuals with type 1 diabetes, the course, tracking and temporal inter-relationships of BP, specifically pulse pressure (a marker of arterial stiffening) and hypertension, and the following biomarkers of systemic and vascular inflammation/endothelial dysfunction: C-reactive protein (CRP), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin)...
November 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/29053674/assessing-urinary-tract-junction-obstruction-defects-by-methylene-blue-dye-injection
#15
Kangsun Yun
Urinary tract junction obstruction defects are congenital anomalies inducing hydronephrosis and hydroureter. Murine urinary tract junction obstruction defects can be assessed by tracking methylene blue dye flow within the urinary system. Methylene blue dye is injected into the renal pelvis of perinatal embryonic kidneys and dye flow is monitored from the renal pelvis of the kidney through the ureter and into the bladder lumen after applying hydrostatic pressure. Dye accumulation will be evident in the bladder lumen of the normal perinatal urinary tract, but will be constrained between the renal pelvis and the end point of an abnormal ureter, if urinary tract obstructions occur...
October 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29022684/legionellosis-a-walk-through-to-identification-of-the-source-of-infection
#16
Dimosthenis Chochlakis, Vassilios Sandalakis, Maria Keramarou, Yannis Tselentis, Anna Psaroulaki
OBJECTIVES: Although a number of human Legionnaires' disease in tourists are recorded annually in Europe, there are few cases where a direct link can be made between the infected person and the source of infection (hotel or other accommodation). We present a scheme followed in order to track down and identify the source of infection in a tourist suffering from L. pneumophila sg 5 infection, who was accommodated in seven different hotels during his holidays in the island of Crete, and we comment on various difficulties and draw-backs of the process...
September 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28923655/coloduodenovesical-fistula-after-simultaneous-pancreas-kidney-transplant-case-report-and-review-of-the-literature
#17
A A Rahnemai-Azar, M Penna, S D Morrison, S C Rayhill, L Sibulesky, K A Muczynski, R Bakthavatsalam
BACKGROUND: Complicated diverticulitis after transplantation occurs in as many as 3.5% of cases and carries a 25% mortality rate. Diagnosis of complicated diverticulitis in this population can be challenging because of abnormal presentations caused by immunosuppression. Only 4 cases of fistulization after kidney transplantation are described in the literature; none occurred after simultaneous pancreas-kidney transplant. METHODS: We present a first case of a coloduodenovesical fistula in a patient 9 years after simultaneous pancreas-kidney transplant...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28902663/aldosterone-induces-left-ventricular-subclinical-systolic-dysfunction-a-strain-imaging-study
#18
Zheng-Wei Chen, Kuan-Chih Huang, Jen-Kuang Lee, Lung-Chun Lin, Ching-Way Chen, Yi-Yao Chang, Che-Wei Liao, Vin-Cent Wu, Chi-Shen Hung, Yen-Hung Lin
BACKGROUND: Primary aldosteronism is associated with a higher incidence of left ventricular (LV) hypertrophy and diastolic dysfunction than essential hypertension. However, systolic function via endocardial measurements is similar between patients with primary aldosteronism and essential hypertension. Speckle-tracking echocardiography is a sensitive tool which can detect subclinical impairments in systolic function. The aim of this study was to investigate aldosterone-induced subclinical impairments in systolic function...
September 11, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28900757/low-incidence-of-postoperative-urinary-retention-with-the-use-of-a-nurse-led-bladder-scan-protocol-after-hip-and-knee-arthroplasty-a-retrospective-cohort-study
#19
N P Kort, Y Bemelmans, R Vos, M G M Schotanus
PURPOSE: Postoperative urinary retention (POUR), defined as the inability to empty the bladder voluntary after surgery, is a commonly reported complication. This study reports the incidence and possible risk factors for POUR after elective fast-track hip or knee arthroplasty when using a nurse-led bladder scan protocol. METHODS: This retrospective cohort study included data from 803 patients who underwent unilateral hip or knee arthroplasty. Patients' digital clinical records were reviewed for eligibility...
September 12, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28874183/urethral-calculi-with-a-urethral-fistula-a-case-report-and-review-of-the-literature
#20
Mingqiang Zeng, Fanchang Zeng, Zhao Wang, Ruizhi Xue, Liang Huang, Xuyu Xiang, Zhi Chen, Zhengyan Tang
BACKGROUND: To explore and summarize the reasons why urethral calculi cause a urethral fistula. CASE PRESENTATION: We retrospectively studied 1 patient in Xiangya hospital and all relevant literature published in English between 1989 and 2015. The patients (including those reported in the literature) were characterized by age, origin, location of calculus, size of calculus, fistulous track, and etiological factors. Most of urethral calculi associated with a urethral fistula were native generated...
September 6, 2017: BMC Research Notes
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