Jun Ma, Han Yu, Xinyu Zhang, Zhuoming Xu, Hanyin Hu, Jintao Liu, Peng Ren, Xiangjia Kong, Jiayi Chen, Kun Yang, Xinyu Wang, Xiaojun He, Huanhuan Luo, Gang Chen
The tendon-bone interface has a complex gradient structure vital for stress transmission and pressure buffering during movement. However, injury to the gradient tissue, especially the tendon and cartilage components, often hinders the complete restoration of the original structure. Here, a metal ion network hydrogel scaffold, with the capability of targeting multitissue, was constructed through the photopolymerization of the LHERHLNNN peptide-modified zeolitic imidazolate framework-8 (LZIF-8) and the WYRGRL peptide-modified magnesium metal-organic framework (WMg-MOF) within the hydrogel scaffold, which could facilitate the directional migration of metal ions to form a dynamic gradient, thereby achieving integrated regeneration of gradient tissues...
January 23, 2024: ACS Applied Materials & Interfaces