keyword
https://read.qxmd.com/read/38472405/glymphatic-lymphatic-coupling-assessment-of-the-evidence-from-magnetic-resonance-imaging-of-humans
#21
REVIEW
Geir Ringstad, Per Kristian Eide
The discoveries that cerebrospinal fluid participates in metabolic perivascular exchange with the brain and further drains solutes to meningeal lymphatic vessels have sparked a tremendous interest in translating these seminal findings from animals to humans. A potential two-way coupling between the brain extra-vascular compartment and the peripheral immune system has implications that exceed those concerning neurodegenerative diseases, but also imply that the central nervous system has pushed its immunological borders toward the periphery, where cross-talk mediated by cerebrospinal fluid may play a role in a range of neoplastic and immunological diseases...
March 13, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38471668/environmental-surveillance-reveals-co-circulation-of-distinctive-lineages-of-enteroviruses-in-southwest-china-s-border-cities-2020-2022
#22
JOURNAL ARTICLE
Jingjing Tang, Xiaodie Zhang, Jie Zhang, Zhixian Zhao, Zhengrong Ding
AIMS: Enteroviruses are significant human pathogens associated with a range of mild to severe diseases. This study aims to understand the diversity and genetic characterization of enteroviruses circulated in southwest China's border cities by using environmental surveillance. METHODS AND RESULTS: A total of 96 sewage samples were collected in three border cities and a port located in Yunnan Province, China from July 2020 to June 2022. After cell culture and VP1 sequencing, a total of 590 enterovirus isolates were identified, belonging to 21 types...
March 1, 2024: Journal of Applied Microbiology
https://read.qxmd.com/read/38470479/chronic-siv-induced-neuroinflammation-disrupts-ccr7-cd4-t-cell-immunosurveillance-in-the-rhesus-macaque-brain
#23
JOURNAL ARTICLE
Sonny R Elizaldi, Chase E Hawes, Anil Verma, Yashavanth Shaan Lakshmanappa, Ashok R Dinasarapu, Brent T Schlegel, Dhivyaa Rajasundaram, Jie Li, Blythe P Durbin-Johnson, Zhong-Min Ma, Pabitra B Pal, Danielle Beckman, Sean Ott, Reben Raeman, Jeffrey Lifson, John H Morrison, Smita S Iyer
CD4 T cells survey and maintain immune homeostasis in the brain, yet their differentiation states and functional capabilities remain unclear. Our approach, combining single-cell transcriptomic analysis, ATAC-seq, spatial transcriptomics, and flow cytometry, revealed a distinct subset of CCR7+ CD4 T cells resembling lymph node central memory (TCM) cells. We observed chromatin accessibility at the CCR7, CD28, and BCL-6 loci, defining molecular features of TCM. Brain CCR7+ CD4 T cells exhibited recall proliferation and interleukin-2 production ex vivo, showcasing their functional competence...
March 12, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38469055/nicorandil-pretreated-mesenchymal-stem-cell-derived-exosomes-facilitate-cardiac-repair-after-myocardial-infarction-via-promoting-macrophage-m2-polarization-by-targeting-mir-125a-5p-traf6-irf5-signaling-pathway
#24
JOURNAL ARTICLE
Zhao-Ting Gong, Yu-Yan Xiong, Yu Ning, Rui-Jie Tang, Jun-Yan Xu, Wen-Yang Jiang, Xiao-Song Li, Li-Li Zhang, Cheng Chen, Qi Pan, Meng-Jin Hu, Jing Xu, Yue-Jin Yang
BACKGROUND: Exosomes derived from bone marrow mesenchymal stem cells (MSC-exo) have been considered as a promising cell-free therapeutic strategy for ischemic heart disease. Cardioprotective drug pretreatment could be an effective approach to improve the efficacy of MSC-exo. Nicorandil has long been used in clinical practice for cardioprotection. This study aimed to investigate whether the effects of exosomes derived from nicorandil pretreated MSC (MSCNIC -exo) could be enhanced in facilitating cardiac repair after acute myocardial infarction (AMI)...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38468661/calvarial-multiple-myeloma-raindrop-skull
#25
Ali Alkhaibary, Ahoud Alharbi, Sami Khairy
BACKGROUND: The "Raindrop skull" appearance represents the multiple punched-out and lytic lesions hitting a surface and creating a scattered splash pattern. CASE DESCRIPTION: A 73-year-old female presented with multiple painless lumps over the forehead and head. The patient reported unintentional weight loss, fatigability, loss of appetite, fever, night sweats, and back pain for seven months (B symptoms). The examination revealed multiple, nonmobile, calvarial lesions with defined borders, measuring approximately 1 × 1 cm...
2024: Surgical Neurology International
https://read.qxmd.com/read/38462274/a-clinical-consensus-compliant-deep-learning-approach-to-quantitatively-evaluate-human-in-vitro-fertilization-early-embryonic-development-with-optical-microscope-images
#26
JOURNAL ARTICLE
Zaowen Liao, Chaoyu Yan, Jianbo Wang, Ningfeng Zhang, Huan Yang, Chenghao Lin, Haiyue Zhang, Wenjun Wang, Weizhong Li
The selection of embryos is a key for the success of in vitro fertilization (IVF). However, automatic quality assessment on human IVF embryos with optical microscope images is still challenging. In this study, we developed a clinical consensus-compliant deep learning approach, named Esava (Embryo Segmentation and Viability Assessment), to quantitatively evaluate the development of IVF embryos using optical microscope images. In total 551 optical microscope images of human IVF embryos of day-2 to day-3 were collected, preprocessed, and annotated...
March 2024: Artificial Intelligence in Medicine
https://read.qxmd.com/read/38460673/intra-abdominal-epithelioid-neoplasm-with-ewsr1-creb-fusions-involving-the-kidney-a-clinicopathologic-and-molecular-characterization-with-an-emphasis-on-differential-diagnosis
#27
JOURNAL ARTICLE
Ming Zhao, Hualei Gan, Shan Zhong, Qiuyan Xia, Yanfeng Bai, Jiayun Xu, Xiaodong Teng, Jian Wang
Soft tissue neoplasms harboring fusions between EWSR1 or FUS with genes encoding CREB transcription factors family (ATF1, CREB1, and CREM) are an emerging heterogeneous group of mesenchymal tumors that differ significantly in morphology, immunophenotypes, and behavior. Recently, EWSR1/FUS::CREB fusions have been recognized to define a group of aggressive neoplasms of epithelioid morphology with multiple growth patterns and a striking predilection for mesothelial-lined cavities. These neoplasms presenting as a primary neoplasm of intra-abdominal visceral organs is rare, which could elicit a wide range of differential diagnoses due to their diverse morphologies and immunohistochemical profiles...
March 7, 2024: Modern Pathology
https://read.qxmd.com/read/38456605/papillary-renal-neoplasm-with-reverse-polarity-is-biologically-and-clinically-distinct-from-eosinophilic-papillary-renal-cell-carcinoma
#28
JOURNAL ARTICLE
Vincent Francis Castillo, Kiril Trpkov, Theodorus Van der Kwast, Fabio Rotondo, Malek Hamdani, Rola Saleeb
Papillary renal neoplasm with reverse polarity (PRNRP) is a recently described indolent entity with distinct features and its recognition from other oncocytic/eosinophilic papillary renal cell carcinoma (ePRCC) has important prognostic implications. ABCC2, a renal drug transporter, is overexpressed in aggressive PRCCs. In this study, we compared the clinicopathological parameters and the biological ABCC2 expression between PRNRP and ePRCC. PRNRP (n = 8) and ePRCC (n = 21) cases were selected from resection specimens and corresponding clinicopathological data were collected...
March 8, 2024: Pathology International
https://read.qxmd.com/read/38454770/a-case-report-of-diffuse-type-tenosynovial-giant-cell-tumor-as-a-calcaneus-mass-a-diagnostic-challenge
#29
Zheng Wang, Xiang Wang, Shutong Zhang
INTRODUCTION: Diffuse-type tenosynovial giant cell tumor (D-TGCT) originates from synovial cells in tendon sheaths and bursae and rarely presents as a calcaneal mass. CASE REPORT: A 44-year-old female presented with left heel pain that had persisted for over a year and had worsened over the past six months. A mass was found on the Lateral radiograph of the calcaneus, which was diagnosed as an aneurysmal bone cyst. Non-contrast computed tomography (CT) and magnetic resonance imaging (MRI)diagnosed a benign tumor...
March 7, 2024: Current medical imaging
https://read.qxmd.com/read/38452864/aspergillus-niger-pneumonia-as-superinfection-in-a-patient-with-pulmonary-tuberculosis
#30
JOURNAL ARTICLE
Santiago Ewig, Sören Gatermann, Stathis Phillipou, Christian Giesa, Erich Hecker
We report a patient with severe cavitary pulmonary tuberculosis and Aspergillus niger superinfection, whose only comorbidity was untreated diabetes mellitus. A. niger pneumonia was proven by PCR, sequencing and culture of pleural and respiratory secretions. The patient was successfully treated with a four-drug antituberculous regimen, liposomal amphotericin B (up to 5 mg/kg/d) and pleuro-pneumonectomy. Histology of the resected lung revealed destroyed lung tissue with inflammatory cells and fungal conidia...
September 2023: Pneumologie
https://read.qxmd.com/read/38451958/morphological-differentiation-of-peritumoral-brain-zone-microglia
#31
JOURNAL ARTICLE
G Anahí Salas-Gallardo, Jonathan-Julio Lorea-Hernández, Ángel Abdiel Robles-Gómez, Claudia Castillo-Martin Del Campo, Fernando Peña-Ortega
The Peritumoral Brain Zone (PBZ) contributes to Glioblastoma (GBM) relapse months after the resection of the original tumor, which is influenced by a variety of pathological factors. Among those, microglia are recognized as one of the main regulators of GBM progression and probably relapse. Although microglial morphology has been analyzed inside GBM and its immediate surroundings, it has not been objectively characterized throughout the PBZ. Thus, we aimed to perform a thorough characterization of microglial morphology in the PBZ and its likely differentiation not just from the tumor-associated microglia but from control tissue microglia...
2024: PloS One
https://read.qxmd.com/read/38440582/-unusual-presentation-of-epitheloid-dermatofibroma-rare-case-report
#32
JOURNAL ARTICLE
Ankita Vasani, Kartik Hirapara, Payal Vadher
Dermatofibroma is a commonly occurring cutaneous entity usually centered within the skin's dermis. Dermatofibromas are referred to as benign fibrous histiocytomas of the skin, superficial/cutaneous benign fibrous histiocytomas, or common fibrous histiocytoma. These mesenchymal cell lesions of the dermis clinically are firm subcutaneous nodules that occur on the extremities in the vast majority of cases and may or may not be associated with overlying skin changes. A 20 years old male presented to ENT OPD, at a private hospital, with complaints of a huge mass over right side of face since 15 years, which was slowly growing and not associated with pain...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38440554/radiotherapy-in-extramedullary-plasmacytoma-of-the-tongue-with-nodal-involvement-a-case-report-with-one-year-follow-up
#33
JOURNAL ARTICLE
Manish Kumar Ahirwar, Siddhartha Nanda, Sourajit Parida, Shiv Shankar Mishra
Tongue extramedullary plasmacytoma (EMP) with regional lymph node metastases is a very rare pathology. Despite being a rare entity, extramedullary plasmacytoma should be considered a differential diagnosis in cases of a mass or ulcer in the tongue. A 60-year-old lady presents with an ulcerative lesion over the right lateral border of the tongue with dimensions 3.5 × 2 cm for one year. Initially, on histopathological examination, a possibility of plasma cell neoplasm was suspected; on further IHC, serum protein electrophoresis, and radiological investigations, a definite diagnosis of solitary EMP of the right lateral border of the tongue with regional nodal metastases was confirmed...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38440508/rare-case-of-squamous-cell-carcinoma-of-midline-dorsum-of-tongue-diagnostic-and-management-dilemma
#34
JOURNAL ARTICLE
Vinay Ganganna, Sourabh Nandi, Sunil Saini, Anshika Arora
Squamous cell carcinoma is the most common carcinoma of the tongue. However, the majority of carcinoma originates in the lateral border of the tongue and midline dorsum only represents about 2-5% of tongue cancer patients. We present a rare case of squamous cell carcinoma in a 59 years old male patient originating in the midline dorsum of tongue and the management dilemma.
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38439725/neutrophilic-dermatosis-of-the-hands-a-case-report
#35
JOURNAL ARTICLE
Reza Yaghoobi, Nooshin Bagherani, Bruce R Smoller, Nader Pazyar
Neutrophilic dermatosis of the hands (NDDH) is a localized variant of Sweet's syndrome which has been recently introduced. Strutton et al.in 1996 and then in Galaria et al. in 2000 reported cases with violaceous papulonodules on the dorsal surfaces of the hands with histopathological findings of a neutrophilic dermatosis in association with leukocytoclasia, but clinically and histologically without true vasculitis findings. Eventually, they proposed the term NDDH for these lesions (1,2). A 46-year-old man was referred to our outpatient dermatology clinic with a painful ulcerative lesion on the dorsal side of the left hand that had been present for one year...
December 2023: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/38434775/clinically-node-negative-invasive-lobular-carcinoma-of-the-breast-showing-multiple-lymph-node-metastases
#36
Yurie Kitano, Shoji Oura
A 73-year-old woman was pointed out of her right breast tumor on screening computed tomography (CT). Mammography showed distortion of the mammary gland and skin retraction. Ultrasound (US) showed an irregular tumor with hyperechoic haloes adjacent to the anterior tumor borders. Neither lymphadenopathy nor image findings suggesting lymph node metastasis were detected on US and CT. Core needle biopsy pathologically showed the tumor to be invasive lobular carcinoma. Under the preoperative diagnosis of node-negative breast cancer, the patient underwent mastectomy and sentinel node biopsy...
May 2024: Radiology Case Reports
https://read.qxmd.com/read/38434604/chemotherapy-extravasation-causing-soft-tissue-necrosis-mimicking-infection-a-longitudinal-case-study
#37
Michael Nguyen, Luke Borders, Jacqueline T Wesolow, John Greene
Extravasation injuries are uncommon, underreported, and often misdiagnosed in patients. The signs and symptoms of extravasation injuries vary from simple pain and tenderness to tissue necrosis and potentially fatal secondary infections. Extravasation may progress to more severe conditions such as necrotizing fasciitis (NF) or cellulitis, so special care is needed by physicians to identify and treat these injuries correctly. Here, we explore a case study on extravasation injuries mimicking NF leading to infectious complications and discuss the proper diagnosis and treatment of extravasation injuries as well as other NF-mimicking diseases...
March 2024: Curēus
https://read.qxmd.com/read/38433049/-clinicopathological-and-genetic-characteristics-of-common-lymphatic-malformations-in-superficial-soft-tissues
#38
JOURNAL ARTICLE
Q Y Liu, C X Li, D K Liu, S Xue, F F Fu, X S Zhu, L F Kong, C X Dong
Objective: To investigate the clinicopathological features, classification, and genetic characteristics of common lymphatic malformation (CLM) in superficial soft tissue. Methods: A retrospective study of 110 patients with the diagnosis of CLM at the Henan Province People's Hospital, China from August 2019 to August 2022 was performed. The clinicopathological features, relevant immunohistochemical (IHC) staining results, and fluorescence quantitative PCR of PIK3CA mutation were analyzed, and patients were followed up...
March 8, 2024: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://read.qxmd.com/read/38432502/cellular-nucleic-acid-binding-protein-facilitates-cardiac-repair-after-myocardial-infarction-by-activating-%C3%AE-catenin-signaling
#39
JOURNAL ARTICLE
Chong Du, Shan Zhao, Tiankai Shan, Xudong Han, Qiqi Jiang, Jiawen Chen, Lingfeng Gu, Tianwen Wei, Tongtong Yang, Sibo Wang, Hao Wang, Xuejiang Guo, Liansheng Wang
The regenerative capacity of the adult mammalian heart is limited, while the neonatal heart is an organ with regenerative and proliferative ability. Activating adult cardiomyocytes (CMs) to re-enter the cell cycle is an effective therapeutic method for ischemic heart disease such as myocardial infarction (MI) and heart failure. Here, we aimed to reveal the role and potential mechanisms of cellular nucleic acid binding protein (CNBP) in cardiac regeneration and repair after heart injury. CNBP is highly expressed within 7 days post-birth while decreases significantly with the loss of regenerative ability...
March 1, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38428416/collective-cell-migration-relies-on-ppp1r15-mediated-regulation-of-the-endoplasmic-reticulum-stress-response
#40
JOURNAL ARTICLE
Yujun Chen, Jocelyn A McDonald
Collective cell migration is integral to many developmental and disease processes. Previously, we discovered that protein phosphatase 1 (Pp1) promotes border cell collective migration in the Drosophila ovary. We now report that the Pp1 phosphatase regulatory subunit dPPP1R15 is a critical regulator of border cell migration. dPPP1R15 is an ortholog of mammalian PPP1R15 proteins that attenuate the endoplasmic reticulum (ER) stress response. We show that, in collectively migrating border cells, dPPP1R15 phosphatase restrains an active physiological protein kinase R-like ER kinase- (PERK)-eIF2α-activating transcription factor 4 (ATF4) stress pathway...
February 27, 2024: Current Biology: CB
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