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DIXDC1

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https://www.readbyqxmd.com/read/27873129/expression-of-dixdc1-and-its-role-in-astrocyte-proliferation-after-traumatic-brain-injury
#1
Hongjian Lu, Rui Jiang, Xuelei Tao, Chengwei Duan, Jie Huang, Wei Huan, Yunfen He, Jianbin Ge, Jianbing Ren
DIX domain containing 1 (Dixdc1), a positive regulator of Wnt signaling pathway, is recently reported to play a role in the neurogenesis. However, the distribution and function of Dixdc1 in the central nervous system (CNS) after brain injury are still unclear. We used an acute traumatic brain injury (TBI) model in adult rats to investigate whether Dixdc1 is involved in CNS injury and repair. Western blot analysis and immunohistochemistry showed a time-dependent up-regulation of Dixdc1 expression in ipsilateral cortex after TBI...
November 21, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27829159/dixdc1-phosphorylation-and-control-of-dendritic-morphology-are-impaired-by-rare-genetic-variants
#2
Vickie Kwan, Durga Praveen Meka, Sean H White, Claudia L Hung, Nicholas T Holzapfel, Susan Walker, Nadeem Murtaza, Brianna K Unda, Birgit Schwanke, Ryan K C Yuen, Kendra Habing, Chloe Milsom, Kristin J Hope, Ray Truant, Stephen W Scherer, Froylan Calderon de Anda, Karun K Singh
The development of neural connectivity is essential for brain function, and disruption of this process is associated with autism spectrum disorders (ASDs). DIX domain containing 1 (DIXDC1) has previously been implicated in neurodevelopmental disorders, but its role in postnatal brain function remains unknown. Using a knockout mouse model, we determined that DIXDC1 is a regulator of excitatory neuron dendrite development and synapse function in the cortex. We discovered that MARK1, previously linked to ASDs, phosphorylates DIXDC1 to regulate dendrite and spine development through modulation of the cytoskeletal network in an isoform-specific manner...
November 8, 2016: Cell Reports
https://www.readbyqxmd.com/read/27817168/knockdown-of-dixdc1-inhibits-the-proliferation-and-migration-of-human-glioma-cells
#3
Jianguo Chen, Chaoyan Shen, Jinlong Shi, Jianhong Shen, Wenjuan Chen, Jie Sun, Shaocheng Fan, Yuanqi Bei, Peng Xu, Hao Chang, Rui Jiang, Lu Hua, Bin Ji, Qingfeng Huang
DIX domain containing 1 (DIXDC1), the human homolog of coiled-coil-DIX1 (Ccd1), is a positive regulator of Wnt signaling pathway. Recently, it was found to act as a candidate oncogene in colon cancer, non-small-cell lung cancer, and gastric cancer. In this study, we aimed to investigate the clinical significance of DIXDC1 expression in human glioma and its biological function in glioma cells. Western blot and immunohistochemistry analysis showed that DIXDC1 was overexpressed in glioma tissues and glioma cell lines...
November 5, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27752079/dixdc1-contributes-to-psychiatric-susceptibility-by-regulating-dendritic-spine-and-glutamatergic-synapse-density-via-gsk3-and-wnt-%C3%AE-catenin-signaling
#4
P-M Martin, R E Stanley, A P Ross, A E Freitas, C E Moyer, A C Brumback, J Iafrati, K S Stapornwongkul, S Dominguez, S Kivimäe, K A Mulligan, M Pirooznia, W R McCombie, J B Potash, P P Zandi, S M Purcell, S J Sanders, Y Zuo, V S Sohal, B N R Cheyette
Mice lacking DIX domain containing-1 (DIXDC1), an intracellular Wnt/β-catenin signal pathway protein, have abnormal measures of anxiety, depression and social behavior. Pyramidal neurons in these animals' brains have reduced dendritic spines and glutamatergic synapses. Treatment with lithium or a glycogen synthase kinase-3 (GSK3) inhibitor corrects behavioral and neurodevelopmental phenotypes in these animals. Analysis of DIXDC1 in over 9000 cases of autism, bipolar disorder and schizophrenia reveals higher rates of rare inherited sequence-disrupting single-nucleotide variants (SNVs) in these individuals compared with psychiatrically unaffected controls...
October 18, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27701018/dixdc1-promotes-tumor-proliferation-and-cell-adhesion-mediated-drug-resistance-cam-dr-via-enhancing-p-akt-in-non-hodgkin-s-lymphomas
#5
Yu Ouyang, Fei Zhong, Qiru Wang, Linlin Ding, Peipei Zhang, Lingling Chen, Yuchan Wang, Chun Cheng
DIX domain containing 1 (DIXDC1), is a human homolog of Ccd1, a DIX domain containing protein in zebrafish. The present study was undertaken to determine the expression and biologic function of DIXDC1 in Non-Hodgkin's lymphoma (NHL). Clinically, we detected that the expression of DIXDC1 was significantly lower in the indolent lymphomas compared with the progressive lymphomas by immunohistochemistry analysis. Functionally, we found that DIXDC1 could promote cell proliferation via modulating cell cycle progression and PI3K/AKT signaling pathway in NHLs...
September 8, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27521891/dixdc1-targets-cyclind1-and-p21-via-pi3k-pathway-activation-to-promote-schwann-cell-proliferation-after-sciatic-nerve-crush
#6
Weijie Wu, Qingqing Liu, Yuxi Liu, Zhaohui Yu, Youhua Wang
Dixdc1 (DIX domain containing-1), the mammalian homolog of Ccd1 (Coiled-coil-Dishevelled-Axin1), is a protein containing a coiled-coil domain and a Dishevelled-Axin (DIX) domain. As a novel component of the Wnt pathway, Dixdc1 has been reported to be able to promote neural progenitor proliferation and neuronal differentiation via Wnt/β-catenin signaling. But there still remains something unknown about Dixdc1 distribution and functions in the lesion and regeneration of the peripheral nervous system (PNS), so we tried to investigate dynamic changes of Dixdc1 expression in a rat sciatic nerve crush (SNC) model in this study...
September 16, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27498060/overexpression-of-dixdc1-correlates-with-enhanced-cell-growth-and-poor-prognosis-in-human-pancreatic-ductal-adenocarcinoma
#7
Xiaohong Li, Ying Xiao, Shaoqing Fan, Mingbing Xiao, Xiaotong Wang, Xiaolin Zhu, Xudong Chen, Chunsun Li, Guijuan Zong, Guoxiong Zhou, Chunhua Wan
DIX domain containing 1 (DIXDC1), a protein containing a coiled-coil domain and a Dishevelled-Axin (DIX) domain, is involved in the progression of multiple cancers. However, the role of DIXDC1 in human pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, we investigated the role and prognostic value of DIXDC1 in the development of human PDAC. Western blot analysis revealed that DIXDC1 was highly expressed in PDAC tissues and cell lines. Immunohistochemistry on 165 paraffin-embedded sections showed that high expression of DIXDC1 was significantly correlated with tumor size (P=...
August 3, 2016: Human Pathology
https://www.readbyqxmd.com/read/27468723/downregulated-expression-of-dixdc1-in-hepatocellular-carcinoma-and-its-correlation-with-prognosis
#8
Senjun Zhou, Jiliang Shen, Shuang Lin, Xiaolong Liu, Ming Xu, Liang Shi, Xianfa Wang, Xiujun Cai
Dishevelled-Axin domain containing 1 (DIXDC1) is a DIX (Dishevelled-Axin) domain possessing protein that acts as a positive regulator of the Wnt pathway. Although DIXDC1 has been investigated in several cancers, it has not yet been studied in human hepatocellular carcinoma (HCC). The purpose of the current study was to investigate the expression pattern of DIXDC1 and assess the clinical significance of DIXDC1 expression in HCC patients. Data containing three independent investigations from Oncomine database demonstrated that DIXDC1 mRNA was downregulated in HCC compared with matched non-cancerous tissues...
July 28, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26944284/a-tale-of-the-good-and-bad-remodeling-of-the-microtubule-network-in-the-brain-by-cdk5
#9
Kavita Shah, Debomoy K Lahiri
Cdk5, a cyclin-dependent kinase family member, is a global orchestrator of neuronal cytoskeletal dynamics. During embryogenesis, Cdk5 is indispensable for brain development. In adults, it is essential for numerous neuronal processes, including higher cognitive functions such as learning and memory formation, drug addiction, pain signaling, and long-term behavior changes through long-term potentiation and long-term depression, all of which rely on rapid alterations in the cytoskeleton. Cdk5 activity becomes deregulated in various brain disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, attention-deficit hyperactivity disorder, epilepsy, schizophrenia, and ischemic stroke; these all result in profound remodeling of the neuronal cytoskeleton...
March 5, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26689843/upregulated-expression-of-dixdc1-in-intestinal-type-gastric-carcinoma-co-localization-with-%C3%AE-catenin-and-correlation-with-poor-prognosis
#10
Lei Wang, Cong Tan, Fan Qiao, Weige Wang, Xiangnan Jiang, Peng Lian, Bin Chang, Weiqi Sheng
BACKGROUND: DIXDC1 (Dishevelled-Axin domain containing 1) is a positive regulator of the Wnt pathway. In the field of cancer research, the role of DIXDC1 is unclear. Our previous in vitro study showed that DIXDC1 enhances β-catenin nuclear accumulation in gastric cancer cell lines. The aim of this study was to detect the expression of DIXDC1 in different histological subtypes of gastric carcinoma and to evaluate the correlation between the expression of DIXDC1 and β-catenin localization and clinicopathological parameters, including patients' survival...
2015: Cancer Cell International
https://www.readbyqxmd.com/read/25648220/dixdc1-activates-the-wnt-signaling-pathway-and-promotes-gastric-cancer-cell-invasion-and-metastasis
#11
Cong Tan, Fan Qiao, Ping Wei, Yayun Chi, Weige Wang, Shujuan Ni, Qifeng Wang, Tongzhen Chen, Weiqi Sheng, Xiang Du, Lei Wang
DIXDC1 (Dishevelled-Axin domain containing 1) is a DIX (Dishevelled-Axin) domain-possessing protein that promotes colon cancer cell proliferation and increases the invasion and migration ability of non-small-cell lung cancer via the PI3K pathway. As a positive regulator of the Wnt/β-catenin pathway, the biological role of DIXDC1 in human gastric cancer and the relationship between DIXDC1 and the Wnt pathway are unclear. In the current study, the upregulation of DIXDC1 was detected in gastric cancer and was associated with advanced TNM stage cancer, lymph node metastasis, and poor prognosis...
April 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/25042806/an-ampk-independent-signaling-pathway-downstream-of-the-lkb1-tumor-suppressor-controls-snail1-and-metastatic-potential
#12
Jonathan M Goodwin, Robert U Svensson, Hua Jane Lou, Monte M Winslow, Benjamin E Turk, Reuben J Shaw
The serine/threonine kinase LKB1 is a tumor suppressor whose loss is associated with increased metastatic potential. In an effort to define biochemical signatures of metastasis associated with LKB1 loss, we discovered that the epithelial-to-mesenchymal transition transcription factor Snail1 was uniquely upregulated upon LKB1 deficiency across cell types. The ability of LKB1 to suppress Snail1 levels was independent of AMPK but required the related kinases MARK1 and MARK4. In a screen for substrates of these kinases involved in Snail regulation, we identified the scaffolding protein DIXDC1...
August 7, 2014: Molecular Cell
https://www.readbyqxmd.com/read/23813858/dixdc1-increases-the-invasion-and-migration-ability-of-non-small-cell-lung-cancer-cells-via-the-pi3k-akt-ap-1-pathway
#13
Zhonghai Xu, Di Liu, Chuifeng Fan, Lan Luan, Xiupeng Zhang, Enhua Wang
DIX domain containing 1 (DIXDC1), is a human homolog of Ccd1, a recently identified DIX domain containing protein in zebrafish. DIXDC1 protein was detected in human colorectal adenocarcinoma tissues and was found to be correlated with a high cell proliferation index. We demonstrated DIXDC1 overexpression in 55% (92/167) of non-small cell lung cancer (NSCLC) cases, compared to adjacent noncancerous lung tissues (P < 0.01). Overexpression of DIXDC1 was associated with lymph node metastasis and more advanced TNM stage (P < 0...
November 2014: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/23667667/huaier-aqueous-extract-inhibits-ovarian-cancer-cell-motility-via-the-akt-gsk3%C3%AE-%C3%AE-catenin-pathway
#14
Xiaohui Yan, Tianjiao Lyu, Nan Jia, Yinhua Yu, Keqin Hua, Weiwei Feng
Traditional Chinese medicine has gained popularity due to its ability to kill tumor cells. Recently, the apoptotic and anti-angiogenic effects of Trametes robiniophila murr (Huaier) have been investigated. The aim of this study was to investigate its effect on cell mobility and tumor growth in ovarian cancer. Cell viability and motility were measured using SRB, scratch and migration assays. Cell apoptosis was analysed by annexin V/PI staining. Using a reverse-phase protein array (RPPA) assay, we analyzed the levels of 153 proteins and/or phosphorylations in Huaier-treated and untreated cells...
2013: PloS One
https://www.readbyqxmd.com/read/23295946/therapeutic-effects-of-microrna-582-5p-and-3p-on-the-inhibition-of-bladder-cancer-progression
#15
Keita Uchino, Fumitaka Takeshita, Ryou-U Takahashi, Nobuyoshi Kosaka, Kae Fujiwara, Haruna Naruoka, Satoru Sonoke, Junichi Yano, Hideo Sasaki, Shiari Nozawa, Miki Yoshiike, Kazuki Kitajima, Tatsuya Chikaraishi, Takahiro Ochiya
Many reports have indicated that the abnormal expression of microRNAs (miRNAs) is associated with the progression of disease and have identified miRNAs as attractive targets for therapeutic intervention. However, the bifunctional mechanisms of miRNA guide and passenger strands in RNA interference (RNAi) therapy have not yet been clarified. Here, we show that miRNA (miR)-582-5p and -3p, which are strongly decreased in high-grade bladder cancer clinical samples, regulate tumor progression in vitro and in vivo...
March 2013: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/22832659/abnormal-behavior-in-mice-mutant-for-the-disc1-binding-partner-dixdc1
#16
S Kivimäe, P-M Martin, D Kapfhamer, Y Ruan, U Heberlein, J L R Rubenstein, B N R Cheyette
Disrupted-in-Schizophrenia-1 (DISC1) is a genetic susceptibility locus for major mental illness, including schizophrenia and depression. The Disc1 protein was recently shown to interact with the Wnt signaling protein, DIX domain containing 1 (Dixdc1). Both proteins participate in neural progenitor proliferation dependent on Wnt signaling, and in neural migration independently of Wnt signaling. Interestingly, their effect on neural progenitor proliferation is additive. By analogy to Disc1, mutations in Dixdc1 may lead to abnormal behavior in mice, and to schizophrenia or depression in humans...
2011: Translational Psychiatry
https://www.readbyqxmd.com/read/21341271/elevation-of-wnt5a-expression-in-polyp-formation-in-lkb1-mice-and-peutz-jeghers-syndrome
#17
Cecilia Lai, James Robinson, Sue Clark, Gordon Stamp, Richard Poulsom, Andrew Silver
Peutz-Jeghers syndrome (PJS) is a rare, inherited disease caused by germline mutation of the LKB1 gene. Patients with PJS develop characteristic polyps in the digestive tract and carry an elevated risk of cancers in multiple organs, including the intestinal tract. While LKB1 is capable of phosphorylating AMPK and regulates the mTOR pathway, it is also known to be a multitasking protein that can influence other cellular processes, including cell polarity. We hypothesized that there may be other biological pathways directly or indirectly affected by the loss of LKB1 in PJS and aimed to investigate this possibility through transcriptional profiling of polyps harvested from an Lkb1(+/-) mouse model of PJS and from PJS patients...
April 2011: Journal of Pathology
https://www.readbyqxmd.com/read/21195721/disc1-binding-proteins-in-neural-development-signalling-and-schizophrenia
#18
REVIEW
Nicholas J Bradshaw, David J Porteous
In the decade since Disrupted in Schizophrenia 1 (DISC1) was first identified it has become one of the most convincing risk genes for major mental illness. As a multi-functional scaffold protein, DISC1 has multiple identified protein interaction partners that highlight pathologically relevant molecular pathways with potential for pharmaceutical intervention. Amongst these are proteins involved in neuronal migration (e.g. APP, Dixdc1, LIS1, NDE1, NDEL1), neural progenitor proliferation (GSK3β), neurosignalling (Girdin, GSK3β, PDE4) and synaptic function (Kal7, TNIK)...
March 2012: Neuropharmacology
https://www.readbyqxmd.com/read/20643344/switching-disc1-function-in-neurogenesis-dixdc1-selects-disc1-binding-partners
#19
COMMENT
Takashi Namba, Kozo Kaibuchi
The schizophrenia-associated protein DISC1 regulates several steps in neurogenesis. In a recent study published in Neuron, Singh et al. showed how DISC1 and its interacting partner Dixdc1 regulate cell proliferation and cell migration in different manners during embryonic neurogenesis.
July 20, 2010: Developmental Cell
https://www.readbyqxmd.com/read/20624590/dixdc1-is-a-critical-regulator-of-disc1-and-embryonic-cortical-development
#20
Karun K Singh, Xuecai Ge, Yingwei Mao, Laurel Drane, Konstantinos Meletis, Benjamin A Samuels, Li-Huei Tsai
The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is regulated during embryonic neural progenitor proliferation and neuronal migration through an interaction with DIX domain containing-1 (Dixdc1), the third mammalian gene discovered to contain a Disheveled-Axin (DIX) domain. We determined that Dixdc1 functionally interacts with DISC1 to regulate neural progenitor proliferation by co-modulating Wnt-GSK3beta/beta-catenin signaling...
July 15, 2010: Neuron
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