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Piperacillin

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https://www.readbyqxmd.com/read/28527651/clinical-efficacy-of-cycling-empirical-antibiotic-therapy-for-febrile-neutropenia-in-pediatric-cancer-patients
#1
Hideto Teranishi, Yuhki Koga, Hisanori Nishio, Wakako Kato, Hiroaki Ono, Shunsuke Kanno, Kentaro Nakashima, Hidetoshi Takada
BACKGROUND: Febrile neutropenia (FN) is the main treatment-related cause of mortality among children with cancer, as the prolonged use of broad-spectrum antibiotics can lead to antibiotic resistance in these patients. Antibiotic cycling has been reported to limit the emergence of antibiotic-resistant bacteria among adult patients. However, no studies have evaluated pediatric patients with FN. METHODS: Between September 2011 and February 2014, 126 pediatric cancer patients were admitted to our center for chemotherapy and/or hematopoietic stem cell transplantation and were included in this study...
May 17, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28522340/acute-kidney-injury-risk-associated-with-piperacillin-tazobactam-compared-with-cefepime-during-vancomycin-therapy-in-hospitalised-patients-a-cohort-study-stratified-by-baseline-kidney-function
#2
Nakyung Jeon, Ben Staley, Kenneth P Klinker, Juan Hincapie Castillo, Almut G Winterstein
Recent studies have found an association between piperacillin/tazobactam when added to vancomycin and acute kidney injury (AKI) risk. However, studies were limited by the small sample size and residual confounding. The aim of this study was to compare the risk of AKI with vancomycin plus piperacillin/tazobactam (VPT) versus vancomycin plus cefepime (VC) and to examine whether pre-existing renal impairment mediates the risk. This was a retrospective cohort study using electronic health records for patients admitted to two hospitals in 2012-2013...
May 15, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28516432/measurement-of-piperacillin-plasma-concentrations-in-cancer-patients-with-suspected-infection
#3
Tobias Rachow, Verena Schlüter, Sibylle Bremer-Streck, Udo Lindig, Sebastian Scholl, Peter Schlattmann, Michael Kiehntopf, Andreas Hochhaus, Marie von Lilienfeld-Toal
BACKGROUND: Piperacillin (PIP) in combination with tazobactam is commonly used for anti-infective treatment in cancer patients. PIP exerts a time-dependent killing. Thus, the maintenance of plasma concentrations above a pre-defined target concentration for a pre-defined time may be relevant for optimal efficacy. It is assumed that PIP-plasma concentrations above the clinical breakpoint of the target pathogen [Pseudomonas aeruginosa, clinical breakpoint at minimal inhibitory concentration (MIC) 16 mg/L] should be reached for 100% of the dosing interval or >4xMIC (64 mg/L) for 50% of the dosing interval...
May 17, 2017: Infection
https://www.readbyqxmd.com/read/28503342/phenotypic-detection-and-antibiogram-of-%C3%AE-lactamase-producing-proteus-species-in-a-tertiary-care-hospital-india
#4
N Pal, S Hooja, R Sharma, R K Maheshwari
BACKGROUND: Proteus species cause a variety of community- and hospital-acquired illnesses. Synthesis of β-lactamases is the predominant mechanism for resistance to β-lactam antibiotics. Among the β-lactamases, extended spectrum β-lactamases (ESBLs) and AmpC β-lactamases are the most common. AIM: The objective of this study was to determine the occurrence of ESBL and AmpC β-lactamases in Proteus species among various clinical isolates at a tertiary care hospital, India...
September 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28501674/target-attainment-with-continuous-dosing-of-piperacillin-tazobactam-in-critical-illness-a-prospective-observational-study
#5
Heleen Aardema, Prashant Nannan Panday, Mireille Wessels, Kay van Hateren, Willem Dieperink, Jos G W Kosterink, Jan-Willem Alffenaar, Jan G Zijlstra
Optimal dosing of β-lactam antibiotics in critically ill patients is a challenge given the unpredictable pharmacokinetic profile of this patient population. Several studies have shown intermittent dosing to often yield inadequate drug concentrations. Continuous dosing is an attractive alternative from a pharmacodynamic point of view. This study evaluated whether, during continuous dosing, piperacillin concentrations reached and maintained a pre-defined target in critically ill patients. Adult patients treated with piperacillin by continuous dosing in the intensive care unit of a university medical centre in The Netherlands were prospectively studied...
May 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28499421/patterns-of-use-and-appropriateness-of-antibiotics-prescribed-to-patients-receiving-haemodialysis-an-observational-study
#6
Katrina Hui, Michelle Nalder, Kirsty Buising, Aspasia Pefanis, Khai Y Ooi, Eugenie Pedagogos, Craig Nelson, Carl M J Kirkpatrick, David C M Kong
BACKGROUND: There are limited published data on the types and appropriateness of oral and intravenous (IV) antibiotics prescribed to patients receiving haemodialysis. This information is critical to optimise antibiotic prescribing. Therefore this study aims to describe the patterns of use and the appropriateness of oral and IV antibiotics prescribed to patients receiving haemodialysis. METHODS: This was a prospective, observational study across four community and two hospital inpatient haemodialysis units in Melbourne, Australia...
May 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28497052/etiological-and-resistance-profile-of-bacteria-involved-in-urinary-tract-infections-in-young-children
#7
Antonio Sorlózano-Puerto, José María Gómez-Luque, Juan de Dios Luna-Del-Castillo, José María Navarro-Marí, José Gutiérrez-Fernández
Background. The objective of this study was to identify the bacteria most frequently responsible for urinary tract infection (UTI) in the population of under-2-year-olds in our geographic area and to evaluate the activity of antibiotics widely used for UTI treatment during a 4-year study period. Materials and Methods. A retrospective analysis was conducted of data on the identification and susceptibility of microorganisms isolated in urine samples from children under 2 years of age. Results. A total of 1,045 uropathogens were isolated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28487993/acinetobacter%C3%A2-baumannii-quorum-sensing-signalling-molecule-induces-the-expression-of-drug-resistance-genes
#8
Yi Dou, Fei Song, Feng Guo, Zengding Zhou, Cailian Zhu, Jun Xiang, Jingning Huan
Quorum-sensing signalling molecules such as N‑acyl homoserine lactones (AHLs) enable certain Gram‑negative bacteria to respond to environmental changes through behaviours, such as biofilm formation and flagellar movement. The present study aimed to identify Acinetobacter baumannii AHLs and assess their influence on antibiotic resistance. A clinical isolate of A. baumannii strain S (AbS) was collected from the wound of a burn patient and high‑performance liquid chromatography and tandem quadrupole or quadrupole time‑of‑flight high‑resolution mass spectrometry was used to identify AbS AHLs...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28486867/hospital-length-of-stay-among-patients-receiving-intermittent-versus-prolonged-piperacillin-tazobactam-infusion-in-the-intensive-care-units
#9
Jeannie D Chan, Timothy H Dellit, John B Lynch
OBJECTIVES: We sought to evaluate clinical outcomes of intensive care unit (ICU) patients following a hospital-wide initiative of prolonged piperacillin/tazobactam (PIP/TAZ) infusion. METHODS: Retrospective observational study of patients >18 years old who was hospitalized in the ICU receiving PIP/TAZ for >72 hours during the preimplementation (June 1, 2010 to May 31, 2011) and postimplementation (July 7, 2011 to June 30, 2014) periods. RESULTS: There were 124 and 429 patients who met inclusion criteria with average age of 54...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28483953/ceftolozane-tazobactam-activity-against-pseudomonas-aeruginosa-clinical-isolates-from-us-hospitals-report-from-an-antimicrobial-surveillance-program-pacts-2012-2015
#10
Dee Shortridge, Mariana Castanheira, Michael A Pfaller, Robert K Flamm
The activity of ceftolozane-tazobactam was compared to the activity of 7 antimicrobials against 3,851 Pseudomonas aeruginosa isolates collected from 32 US hospitals in the Program to Assess Ceftolozane-Tazobactam Susceptibility from 2012-2015. Ceftolozane-tazobactam and comparator susceptibilities were determined using the CLSI broth microdilution method at a central monitoring laboratory. For ceftolozane-tazobactam, 97.0% of the isolates were susceptible. Susceptibilities of the other antibacterials tested were: amikacin, 96...
May 8, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28476706/management-of-antibiotic-associated-pseudomembranous-colitis-in-non-hospitalized-and-hospitalized-patients
#11
Chun-Feng Tian, Bai-Yu Su, Yu-Juan Li, Yu-Hong Tong, Xu-Hong Zhao, Jian-Ying Liang, Shun-Bao Li, Bu-Lang Gao
Proper management of antibiotic-associated pseudo membranous colitis is not clear. This article is to investigate proper treatment of antibiotic-associated pseudo membranous colitis. Data of 67 patients (aged 18-69 years, with 31 males and 46 females) with antibiotic-associated pseudo membranous colitis were retrospectively analyzed including the demography, antibiotics to induce and for treatment of the pseudo membranous colitis, and other supportive measures. All 67 patients had a positive cytotoxin test, which confirmed the pseudo membranous colitis...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28469034/what-s-hapten-ing-in-%C3%AE-lactam-hypersensitivity
#12
Kathryn Dupnik
Piperacillin binding to proteins can but does not always induce a hypersensitivity reaction.
May 3, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28465811/frequency-of-extended-spectrum-beta-lactamases-esbls-in-strains-of-klebsiella-and-e-coli-isolated-from-patients-hospitalized-in-yazd
#13
Hengameh Zandi, Seyed Mostafa Tabatabaei, Fatemeh Ehsani, Mojtaba Babaei Zarch, Samira Doosthosseini
INTRODUCTION: Frequency of extended-spectrum beta-lactamases (ESBLs) and its variants may vary in different geographical areas, as reports indicate their spread in some certain communities. The aim of this study was to determine the frequency of ESBLs in strains of Klebsiella and E. coli, isolated from patients hospitalized in teaching hospitals of Yazd. METHODS: This cross-sectional study was carried out on samples including E. coli and Klebsiella strains collected from laboratories of Shahid Sadoughi and Shahid Rahnemoun hospitals in Yazd, Iran in the period of 2011-2012...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28463218/-aerobic-etiology-of-acute-appendicitis-in-adults-multicenter-study-of-abdominal-sepsis-in-argentina
#14
Pablo G Scapellato, Pedro Pessacq, Alejandra Corso, Fernando Pasteran, Melina Rapoport, Walter Vasen, Corina Nemirovsky, Aníbal Calmaggi
Antibiotic treatment for acute appendicitis is empirically chosen, based on epidemiological information. Resistance rates are different between regions and there are limited data on the situation in Argentina. As a part of a multicenter, observational study of abdominal infections, we performed the analysis of adult patients diagnosed with appendicitis, enrolled in 16 centers of 5 provinces, between Jan/01/2014 and Jun/30/2015. The aim was to analyze the prevalent aerobic pathogens, their resistance rates and the antimicrobial prescription pattern...
2017: Medicina
https://www.readbyqxmd.com/read/28458296/effectiveness-of-a-computer-facilitated-pharmacist-driven-antimicrobial-stewardship-program-for-infection-management
#15
Kengo Ohashi, Tomoko Matsuoka, Yasutaka Shinoda, Shinya Yoshida, Kaori Arai, Misa Kato, Takayuki Mori, Tomoaki Yoshimura
 In recent years, hospitals have routinely implemented antimicrobial stewardship (AS) programs, and it is important that these programs are effective. Consequently, we utilized a customized computer system to support infection management and implemented a pharmacist-driven AS program in our hospital. Using this computer system, a pharmacist monitored the daily usage of carbapenems and agents against anti-methicillin-resistant Staphylococcus aureus and generated a patient database. With the use of this computer system, we found that the patient database entry time significantly decreased from 24 to 12 min (p<0...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28457027/changing-antimicrobial-resistance-pattern-of-isolates-from-an-icu-over-a-3-year-period
#16
Zarine Khety, Guruparasad Mohanta, Sachin Jain, Sameer Dawoodi
OBJECTIVE: To study the changing patterns of antimicrobial resistance in gram negative bacilli esp. Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa species and Gram positive Staphylococcus aureus isolates from a 37 bedded ICU of a private hospital. METHODS: Antibiotic susceptibilities were determined by using disk diffusion and Vitek-2 system. RESULTS: A total of 13410 clinical samples were screened over a period of 3 years, among which 16...
February 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28454524/cost-effectiveness-of-ceftolozane-tazobactam-compared-with-piperacillin-tazobactam-as-empiric-therapy-based-on-the-in-vitro-surveillance-of-bacterial-isolates-in-the-united-states-for-the-treatment-of-complicated-urinary-tract-infections
#17
Teresa L Kauf, Vimalanand S Prabhu, Goran Medic, Rebekah H Borse, Benjamin Miller, Jennifer Gaultney, Shuvayu S Sen, Anirban Basu
BACKGROUND: A challenge in the empiric treatment of complicated urinary tract infection (cUTI) is identifying the initial appropriate antibiotic therapy (IAAT), which is associated with reduced length of stay and mortality compared with initial inappropriate antibiotic therapy (IIAT). We evaluated the cost-effectiveness of ceftolozane/tazobactam compared with piperacillin/tazobactam (one of the standard of care antibiotics), for the treatment of hospitalized patients with cUTI. METHODS: A decision-analytic Monte Carlo simulation model was developed to compare the costs and effectiveness of empiric treatment with either ceftolozane/tazobactam or piperacillin/tazobactam in hospitalized adult patients with cUTI infected with Gram-negative pathogens in the US...
April 28, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28450951/characteristics-of-carbapenemase-producing-klebsiella-pneumoniae-as-a-cause-of-neonatal-infection-in-shandong-china
#18
Yan Jin, Xiaofei Song, Yigang Liu, Yong Wang, Bingchang Zhang, Hui Fan, Chunhong Shao
The goal of the present study was to examine the characteristics of carbapenem-resistant Klebsiella pneumoniae as a cause of neonatal infection. A total of 37 carbapenem-resistant Klebsiella pneumoniae-positive newborns hospitalized in Shandong Provincial Hospital, China between April 2011 and October 2013 were examined. Antibiotic susceptibility testing was performed using the agar dilution method and the Etest. Resistance genes were assessed by polymerase chain reaction (PCR) and sequencing. Pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST) were used to determine the genotypes and homology of these isolates...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28449875/development-and-validation-of-a-quantitative-confirmatory-method-for-30-%C3%AE-lactam-antibiotics-in-bovine-muscle-using-liquid-chromatography-coupled-to-tandem-mass-spectrometry
#19
M Di Rocco, M Moloney, T O'Beirne, S Earley, B Berendsen, A Furey, M Danaher
A method was developed for the confirmatory and quantitative analysis of 30 β-lactam antibiotic residues in bovine muscle. The method includes 12 penicillins (amoxicillin, ampicillin, cloxacillin, dicloxacillin, mecillinam, methicillin, nafcillin, oxacillin, penicillin G, penicillin V, piperacillin, ticarcillin), 12 cephalosporins (cefacetrile, cefadroxil, cephalexin, cefalonium, cefazolin, cefoperazone, cefotaxime, cefquinome, cefuroxime, desacetyl cephapirin, desfuroylceftiofur cysteine disulfide, desfuroylceftiofur dimer), five carbapenems (biapenem, doripenem, ertapenem, imipenem, meropenem) and faropenem...
April 12, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28446572/evaluation-of-the-accelerate-pheno%C3%A2-system-for-fast-identification-and-antimicrobial-susceptibility-testing-from-positive-blood-culture-in-gram-negative-bloodstream-infection
#20
Matthias Marschal, Johanna Bachmaier, Ingo Autenrieth, Philipp Oberhettinger, Matthias Willmann, Silke Peter
Bloodstream infections (BSI) are an important cause of morbidity and mortality. Increasing rates of antimicrobial resistant pathogens limit treatment options, prompting an empirical use of broad-range antibiotics. Fast and reliable diagnostic tools are needed to provide adequate therapy in a timely manner and to enable a de-escalation of treatment.The Accelerate Pheno™ system (Accelerate Diagnostics, USA) is a fully automated test system that performs both identification (ID) and antimicrobial susceptibility testing (AST) directly from positive blood cultures within approx...
April 26, 2017: Journal of Clinical Microbiology
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