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Juvenil idiopathic arthritis

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https://www.readbyqxmd.com/read/29217290/growth-patterns-in-early-juvenile-idiopathic-arthritis-results-from-the-childhood-arthritis-prospective-study-caps
#1
Flora McErlane, Roberto Carrasco, Lianne Kearsley-Fleet, Eileen M Baildam, Lucy R Wedderburn, Helen E Foster, Yiannis Ioannou, S E Alice Chieng, Joyce E Davidson, Wendy Thomson, Kimme L Hyrich
OBJECTIVES: To investigate early vertical growth patterns and factors associated with poor growth in a modern inception cohort of UK children with juvenile idiopathic arthritis (JIA) using data from the Childhood Arthritis Prospective Study (CAPS). METHODS: A study period of 3 years was chosen. Children included in this analysis had a physician diagnosis of JIA and had height measurements available at both baseline and at 3-years of follow-up. Height is presented as z-scores calculated using World Health Organisation growth standards for age and gender...
November 7, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29214394/serious-adverse-events-associated-with-anti-tumor-necrosis-factor-alpha-agents-in-pediatric-onset-inflammatory-bowel-disease-and-juvenile-idiopathic-arthritis-in-a-real-life-setting
#2
Serena Pastore, Samuele Naviglio, Arianna Canuto, Loredana Lepore, Stefano Martelossi, Alessandro Ventura, Andrea Taddio
OBJECTIVES: Anti-tumor necrosis factor alpha (anti-TNF-α) agents are generally well tolerated, yet they can be associated with serious adverse events (SAEs) in a minority of patients. We examined the incidence of SAEs in a pediatric referral center for chronic rheumatologic and gastroenterological inflammatory disorders. METHODS: Retrospective analysis of SAEs occurring during treatment with anti-TNF-α agents in patients with juvenile idiopathic arthritis (JIA) (n = 78)  or pediatric-onset inflammatory bowel disease (IBD) (n = 105) seen at the Institute for Maternal and Child Health IRCCS "Burlo Garofolo" in Trieste, Italy, between June 2001 and February 2016...
December 6, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29202618/synovial-fluid-proteomics-in-the-pursuit-of-arthritis-mediators-an-evolving-field-of-novel-biomarker-discovery
#3
Shalini M Mahendran, Katerina Oikonomopoulou, Eleftherios P Diamandis, Vinod Chandran
Synovial fluid (SF) is a protein-rich fluid produced into the joint cavity by cells of the synovial membrane. Due to its direct contact with articular cartilage, surfaces of the bone, and the synoviocytes of the inner membrane, it provides a promising reflection of the biochemical state of the joint under varying physiological and pathophysiological conditions. This property of SF has been exploited within numerous studies in search of unique biomarkers of joint pathologies with the ultimate goal of developing minimally invasive clinical assays to detect and/or monitor disease states...
December 4, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29196380/disease-activity-of-juvenile-idiopathic-arthritis-during-and-after-pregnancy-a-prospective-multicenter-study
#4
Kristin Ursin, Stian Lydersen, Johan F Skomsvoll, Marianne Wallenius
OBJECTIVE: To study disease activity in women with juvenile idiopathic arthritis (JIA) during and after pregnancy. There is little previous knowledge about this topic. METHODS: Our study included 135 pregnancies in 114 women with JIA. Disease activity was assessed at 7 timepoints before, throughout, and after pregnancy with the Disease Activity Score-28-C-reactive protein 3 (DAS28-CRP3). Scores assessed at each visit were analyzed in a linear mixed model. The same statistical method was used to study self-reported physical function, pain, and mental health...
December 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29195002/validation-of-classification-criteria-of-macrophage-activation-syndrome-in-japanese-patients-with-systemic-juvenile-idiopathic-arthritis
#5
Masaki Shimizu, Mao Mizuta, Takahiro Yasumi, Naomi Iwata, Yuka Okura, Noriko Kinjo, Hiroaki Umebayashi, Tomohiro Kubota, Yasuo Nakagishi, Kenichi Nishimura, Masato Yashiro, Junko Yasumura, Kazuko Yamazaki, Hiroyuki Wakiguchi, Nami Okamoto, Masaaki Mori
OBJECTIVE: To validate whether the 2016 ACR/EULAR classification criteria of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (s-JIA) is practical in the real world. METHODS: A combination of expert consensus and analysis of real patient data was conducted by a panel of 15 paediatric rheumatologists. Sixty five profiles comprised 18 patients with s-JIA-associated MAS and 47 patients with active s-JIA without evidence of MAS...
December 1, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29194108/epigenetics-of-inflammatory-arthritis
#6
Deepa Hammaker, Gary S Firestein
PURPOSE OF REVIEW: Aberrant epigenetic changes in DNA methylation, histone marks, and noncoding RNA expression regulate the pathogenesis of many rheumatic diseases. The present article will review the recent advances in the epigenetic profile of inflammatory arthritis and discuss diagnostic biomarkers and potential therapeutic targets. RECENT FINDINGS: Methylation signatures of fibroblast-like synoviocytes not only distinguish rheumatoid arthritis (RA) and osteoarthritis (OA), but also early RAs from late RAs or juvenile idiopathic arthritis...
November 30, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29185965/ultrasound-changes-in-synovial-abnormalities-induced-by-treatment-in-juvenile-idiopathic-arthritis
#7
Stefano Lanni, E H Pieter van Dijkhuizen, Federica Vanoni, Stefania Viola, Francesca Magnaguagno, Gian Michele Magnano, Carlo Gandolfo, Angelo Ravelli, Clara Malattia
OBJECTIVES: To investigate the capacity of ultrasound (US) to detect improvement of synovial abnormalities induced by treatment in juvenile idiopathic arthritis (JIA). METHODS: Eighty-three joints (33 knees, 22 tibiotalar, 10 wrists, 9 elbows, 9 subtalar joints) of 33 patients with new-onset JIA were assessed by US at study entry and 6 months after a therapeutic intervention. Each joint was scored for grey-scale (GS) and power Doppler (PD) abnormalities according to a 4-point semiquantitative scale...
November 28, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29184458/update-on-the-management-of-systemic-juvenile-idiopathic-arthritis-and-role-of-il-1-and-il-6-inhibition
#8
REVIEW
Sriharsha Grevich, Susan Shenoi
Systemic juvenile idiopathic arthritis (SJIA) is a disease marked with arthritis and several features of systemic inflammation including fevers, rashes, hepatosplenomegaly, lymphadenopathy, and serositis. The presentation can be variable and arthritis can be a later feature. Macrophage activation syndrome can be a life-threatening complication of this illness and requires early recognition and prompt therapy. Advancements in understanding the biology of SJIA have led to the development of cytokine-targeted therapies, mainly interleukin-1 (IL-1) and IL-6 inhibitors that have significantly improved outcomes...
2017: Adolescent Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29175824/patterns-of-pain-over-time-among-children-with-juvenile-idiopathic-arthritis
#9
Amir Rashid, Lis Cordingley, Roberto Carrasco, Helen E Foster, Eileen M Baildam, Alice Chieng, Joyce E Davidson, Lucy R Wedderburn, Yiannis Ioannou, Flora McErlane, Suzanne M M Verstappen, Kimme L Hyrich, Wendy Thomson
OBJECTIVES: Pain is a very common symptom of juvenile idiopathic arthritis (JIA). Disease activity alone cannot explain symptoms of pain in all children, suggesting other factors may be relevant. The objectives of this study were to describe the different patterns of pain experienced over time in children with JIA and to identify predictors of which children are likely to experience ongoing pain. METHODS: This study used longitudinal-data from patients (aged 1-16 years) with new-onset JIA...
November 25, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29173699/lyme-disease-and-juvenile-idiopathic-arthritis-a-pediatric-case-report
#10
Mário Correia de Sá, Catarina Moreira, Cláudia Melo, Álvaro Sousa, Sónia Carvalho
No abstract text is available yet for this article.
November 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29173698/reduced-activation-and-cd3-lymphocyte-recruitment-after-tnf-inhibitor-use-evaluation-of-clinical-and-99mtc-okt3-scintigraphic-response-in-a-patient-with-juvenile-idiopathic-arthritis
#11
Flavia Paiva Proença Lobo Lopes, Sergio Augusto Lopes de Souza, Blanca Elena Rios Gomes Bica, Lea Mirian Barbosa da Fonseca, Mario Newton Leitão de Azevedo, Bianca Gutfilen
No abstract text is available yet for this article.
November 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29173696/presence-of-riziform-bodies-in-a-patient-with-juvenile-idiopathic-arthritis-case-report-and-literature-review
#12
Leonardo Rodrigues Campos, Fernanda Cardoso das Neves Sztajnbok, Stélio Galvão, Marise de Araújo Lessa, Ierecê Lins Aymoré, Flavio Sztajnbok
No abstract text is available yet for this article.
November 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29170273/optimization-of-quantitative-dynamic-postgadolinium-mri-technique-using-normalized-ratios-for-the-evaluation-of-temporomandibular-joint-synovitis-in-patients-with-juvenile-idiopathic-arthritis
#13
P Caruso, K Buch, S Rincon, R Hakimelahi, Z S Peacock, C M Resnick, C Foster, L Guidoboni, T Donahue, R Macdonald, H Rothermel, H D Curtin, L B Kaban
BACKGROUND AND PURPOSE: MR imaging has been shown to be useful in the diagnosis of juvenile idiopathic arthritis of the temporomandibular joint. Prior MR imaging approaches have relied mainly on the subjective interpretation of synovial enhancement as a marker for synovial inflammation. Although, more recently, several attempts have been made to quantify synovial enhancement, these methods have not taken into account the dynamic enhancement characteristics of the temporomandibular joint and the effect of sampling time...
November 23, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29168357/predictors-of-methotrexate-response-in-turkish-children-with-oligoarticular-and-polyarticular-juvenile-idiopathic-arthritis
#14
Ezgi Deniz Batu, Hafize Emine Sönmez, Bora Gülhan, Zehra Serap Arıcı, Rezan Topaloğlu, Yelda Bilginer
Batu ED, Sönmez HE, Gülhan B, Arıcı ZS, Topaloğlu R, Bilginer Y. Predictors of methotrexate response in Turkish children with oligoarticular and polyarticular juvenile idiopathic arthritis. Turk J Pediatr 2017; 59: 6-12. Methotrexate (MTX) is the most commonly used disease modifying anti-rheumatic drug in juvenile idiopathic arthritis (JIA). We aimed to define predictor factors for response to MTX in Turkish children with oligo- and polyarticular JIA. We reviewed the medical files of 59 oligo- and 57 polyarticular JIA patients seen in the clinic between May 2008 and May 2013 and who received MTX for ≥6 months...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29166924/experience-with-etanercept-tocilizumab-and-interleukin-1-inhibitors-in-systemic-onset-juvenile-idiopathic-arthritis-patients-from-the-biker-registry
#15
Gerd Horneff, Anna Carina Schulz, Jens Klotsche, Anton Hospach, Kirsten Minden, Ivan Foeldvari, Ralf Trauzeddel, Gerd Ganser, Frank Weller-Heinemann, Johannes Perter Haas
BACKGROUND: Treatment of systemic onset juvenile idiopathic arthritis JIA (sJIA), although dramatically improved, remains a challenge. Experience from clinical practice will be presented using data from the German Biologics register (BiKeR) for evaluation of efficacy and safety of treatment with etanercept (ETA), tocilizumab (TOC) and the interleukin-1 inhibitors anakinra and canakinumab (IL-1i) in sJIA. METHODS: Patients with sJIA documented in the BIKeR register, who were exposed to ETA, TOC or IL-1i were identified...
November 22, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29160524/a-fatal-case-of-tuberculous-meningitis-in-a-child-with-juvenile-idiopathic-arthritis-a-diagnostic-challenge
#16
Zumrut Sahbudak Bal, Pinar Yazici, Semra Sen, Cenk Eraslan, Cengiz Cavusoglu, Bulent Karapinar, Fadil Vardar
The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29157059/90k-immunostimulatory-glycoprotein-in-children-with-juvenile-idiopathic-arthritis
#17
Cristina Cecamore, Manuela Marsili, Roberta Salvatore, Roberto Troiani, Maurizia D'Egidio, Nicola Tinari, Piernicola Pelliccia, Francesco Chiarelli, M Loredana Marcovecchio, Luciana Breda
OBJECTIVES: To assess whether circulating levels of 90K glycoprotein are increased in children with juvenile idiopathic arthritis (JIA) at different stages of the disease, compared to healthy controls and to evaluate potential over time changes in its concentrations following treatment with the antitumor-necrosis factor (TNF) drug etanercept. METHODS: 90K glycoprotein, C-reactive protein, erythrocyte sedimentation rate, TNF, antinuclear antibodies, rheumatoid factor and the Juvenile Arthritis Disease Activity Score were assessed in 71 children: 23 with newly diagnosed JIA, 23 with established and active JIA and 25 healthy controls...
November 20, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29153241/treatment-of-the-temporomandibular-joint-in-a-child-with-juvenile-idiopathic-arthritis
#18
REVIEW
Eric J Granquist
The oral and maxillofacial surgeon is instrumental in the management and care of pediatric patients with juvenile idiopathic arthritis (JIA) and should include JIA in the differential when evaluating pediatric patients with temporomandibular joint (TMJ) dysfunction. Medical management has largely decreased the need for surgical intervention, but these patients may require intraarticular steroid injections of the TMJ, close follow-up to monitor their facial growth, and management of the subsequent postinflammatory degenerative TMJ changes...
February 2018: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/29153240/acquired-abnormalities-of-the-temporomandibular-joint
#19
REVIEW
Anne-Frédérique Chouinard, Leonard B Kaban, Zachary S Peacock
Mandibular growth is a complex process that involves the "functional matrix," an interaction of the muscles of mastication, occlusion, and jaw function. Although not a typical growth center, the mandibular condyle has a significant effect on the ultimate size, shape and function of the mandible and secondarily on overall facial form. Acquired temporomandibular joint (TMJ)/condylar abnormalities, such as juvenile idiopathic arthritis, idiopathic condylar resorption, TMJ ankylosis, and condylar hyperplasia, often result in facial deformity and functional deficits...
February 2018: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/29148422/anti-adalimumab-antibodies-in-juvenile-idiopathic-arthritis-related-uveitis
#20
Sanna T Leinonen, Kristiina Aalto, Kaisu M Kotaniemi, Tero T Kivelä
OBJECTIVES: To evaluate the association of adalimumab trough levels and anti-adalimumab antibodies with activity of uveitis in juvenile idiopathic arthritis-related uveitis. METHODS: This was a retrospective observational case series in a clinical setting at the Department of Ophthalmology, Helsinki University Hospital, Finland in 2014-2016. Thirty-one paediatric patients with chronic anterior juvenile idiopathic arthritis-related uveitis in 58 eyes and who had been on adalimumab ≥6 months were eligible for the study...
November 14, 2017: Clinical and Experimental Rheumatology
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