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Juvenil idiopathic arthritis

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https://www.readbyqxmd.com/read/28320056/health-related-quality-of-life-in-an-inception-cohort-of-children-with-juvenile-idiopathic-arthritis-a-longitudinal-analysis
#1
Kiem Oen, Jaime Guzman, Brenden Dufault, Lori B Tucker, Natalie J Shiff, Karen Watanabe Duffy, Jennifer J Y Lee, Brian M Feldman, Roberta A Berard, Paul Dancey, Adam M Huber, Rosie Scuccimarri, David A Cabral, Kimberly A Morishita, Suzanne E Ramsey, Alan M Rosenberg, Gilles Boire, Susanne M Benseler, Bianca Lang, Kristin Houghton, Paivi M Miettunen, Gaëlle Chédeville, Deborah M Levy, Alessandra Bruns, Heinrike Schmeling, Elie Haddad, Rae S M Yeung, Ciarán M Duffy
OBJECTIVES: To describe changes in health-related quality of life (HRQL) over time in children with juvenile idiopathic arthritis (JIA), relative to other outcomes; to identify predictors of unfavourable HRQL trajectories. METHODS: Children with JIA in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort were included. The Juvenile Arthritis Quality of Life Questionnaire (JAQQ, a standardized instrument), health-related Quality of My Life (HRQoML, an instrument based on personal valuations) and JIA core variables were completed serially...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28299312/genetic-screening-of-mutations-associated-with-fabry-disease-in-a-nationwide-cohort-of-juvenile-idiopathic-arthritis-patients
#2
Maria J Gonçalves, Ana F Mourão, António Martinho, Olívia Simões, José Melo-Gomes, Manuel Salgado, Paula Estanqueiro, Célia Ribeiro, Iva Brito, João E Fonseca, Helena Canhão
Fabry's disease (FD) is a lysosomal storage disorder associated with an alpha-galactosidase A deficiency. The prevalence of FD among juvenile idiopathic arthritis (JIA) patients with established diagnosis is unknown, but as musculoskeletal pain may be an important complaint at presentation, misdiagnosed cases are anticipated. With this study, we aim to calculate the frequency of FD-associated mutations in a cohort of JIA patients. Children with JIA from a national cohort were selected. Clinical and laboratorial information was recorded in the Portuguese rheumatic diseases register (http://Reuma...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28296284/pro-inflammatory-cytokine-environments-can-drive-il-17-over-expression-by-%C3%AE-%C3%AE-t-cells-in-systemic-juvenile-idiopathic-arthritis
#3
Christoph Kessel, Katrin Lippitz, Toni Weinhage, Claas Hinze, Helmut Wittkowski, Dirk Holzinger, Ndate Fall, Alexei A Grom, Niklas Gruen, Dirk Foell
OBJECTIVE: Systemic-onset juvenile idiopathic arthritis (sJIA) is speculated to follow a biphasic course with an initial systemic disease phase driven by innate immune mechanisms and interleukin (IL)-1β as a key cytokine, while a second chronic arthritic phase may be dominated by adaptive immunity and cytokines such as IL-17A. Although a recent mouse model points to a critical role of IL-17 expressing γδT cells in disease pathology, in human patients both the prevalence of IL-17 as well as the role of producing cells are still unclear...
March 15, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28293968/clinical-pharmacology-of-tocilizumab-for-the-treatment-of-polyarticular-course-juvenile-idiopathic-arthritis
#4
Xiaoping Zhang, Ya-Chi Chen, Kimio Terao
The efficacy and safety of tocilizumab (TCZ), a humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis (pJIA) were demonstrated in clinical trials. Area covered: A literature search was undertaken in the public domain from 1995 to 2016. Data included in the regulatory submission leading to approval of TCZ for the treatment of pJIA in the European Union, United States, and Japan were also presented. TCZ 10 mg/kg in patients weighing <30 kg provided pharmacokinetic exposure comparable to that of TCZ 8 mg/kg for patients ≥30 kg...
March 15, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28293458/the-novel-use-of-combined-il-1-and-il-6-inhibition-in-a-patient-with-severe-aggressive-erosive-systemic-onset-juvenile-idiopathic-arthritis
#5
Martin Lee, John Isaacs
Systemic-onset juvenile idiopathic arthritis (SoJIA) is a form of juvenile idiopathic arthritis (JIA) that typically presents with prominent systemic features and accounts for approximately 10-15% of children with JIA. Pro-inflammatory cytokine pathways are thought to be involved in its pathogenesis, including interleukin-1 (IL-1) and interleukin-6 (IL-6), and laboratory tests demonstrate a prominent inflammatory response with high CRP and ferritin levels. We present a case of severe, aggressive, erosive SoJIA in a 17-year-old male resistant to multiple biologic therapies treated with a novel combination of IL-1 and IL-6 blockade along with subcutaneous methotrexate...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28293448/serum-calreticulin-as-a-novel-biomarker-of-juvenile-idiopathic-arthritis-disease-activity
#6
Nashwa Ismail Hashaad, Rasha Mohamed Fawzy, Abeer Ahmed Abo Elazem, Mohamed Ibrahim Youssef
OBJECTIVE: This study aimed to investigate the relations between calreticulin (CRT) serum level and both disease activity and severity parameters in juvenile idiopathic arthritis (JIA). MATERIAL AND METHODS: In this study, 60 children with JIA and 50 age-and-sex-matched healthy subjects were enrolled. The assessment of the disease activity was done using juvenile arthritis disease activity score 27 (JADAS-27). The assessment of disease severity was done via gray-scale ultrasonography (US) and power Doppler US (PDUS)...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28291375/juvenile-idiopathic-arthritis-what-is-the-utility-of-ultrasound
#7
Hershernpal A S Basra, Paul D Humphries
Juvenile Idiopathic Arthritis is a heterogeneous condition and an important cause of acquired disability in children. Evidence supports early treatment to prevent future complications. This relies on prompt diagnosis, achieved by a high index of clinical suspicion and supportive evidence, including the detection of joint and or tendon inflammation. Ultrasound is a readily accessible, well tolerated, safe and accurate modality for assessing joints and the surrounding soft tissues. It can also be used to guide therapy into those joints and tendon sheaths, resistant to systemic treatments...
March 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28291196/-cytokine-profile-changes-in-children-with-juvenile-idiopathic-arthritis-associated-uveitis
#8
E A Drozdova, E V Yadykina, E A Mezentseva, K V Nikushkina
AIM: to identify the differences between serum cytokine profiles in juvenile idiopathic arthritis (JIA) with or without uveal tract inflammation. MATERIAL AND METHODS: Serum cytokine profiles were studied in two groups of patients: 20 children with JIA and JIA-associated uveitis and 33 children, who had no signs of uveitis under basic therapy for their JIA. All the patients showed drug remission of articular syndrome. Inflammation of the choroid took the form of chronic anterior uveitis...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28290137/sarilumab-first-global-approval
#9
Lesley J Scott
Sarilumab (Kevzara™) is a fully human IgG1 monoclonal antibody that binds specifically to both soluble and membrane-bound interleukin (IL)-6 receptors (sIL-6Rα and mIL-6Rα) and thereby inhibits IL-6-mediated signalling through these receptors. Subcutaneous sarilumab is approved in Canada for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more biological or non-biological disease-modifying anti-rheumatic drugs. It is under regulatory review for use in rheumatoid arthritis in other countries, including in the EU, USA and Japan...
March 13, 2017: Drugs
https://www.readbyqxmd.com/read/28290112/protecting-bone-health-in-pediatric-rheumatic-diseases-pharmacological-considerations
#10
REVIEW
Yujuan Zhang, Diana Milojevic
Bone health in children with rheumatic conditions may be compromised due to several factors related to the inflammatory disease state, delayed puberty, altered life style, including decreased physical activities, sun avoidance, suboptimal calcium and vitamin D intake, and medical treatments, mainly glucocorticoids and possibly some disease-modifying anti-rheumatic drugs. Low bone density or even fragility fractures could be asymptomatic; therefore, children with diseases of high inflammatory load, such as systemic onset juvenile idiopathic arthritis, juvenile dermatomyositis, systemic lupus erythematosus, and those requiring chronic glucocorticoids may benefit from routine screening of bone health...
March 13, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28288683/chromatin-landscapes-and-genetic-risk-for-juvenile-idiopathic-arthritis
#11
Lisha Zhu, Kaiyu Jiang, Karstin Webber, Laiping Wong, Tao Liu, Yanmin Chen, James N Jarvis
BACKGROUND: The transcriptomes of peripheral blood cells in children with juvenile idiopathic arthritis (JIA) have distinct transcriptional aberrations that suggest impairment of transcriptional regulation. To gain a better understanding of this phenomenon, we studied known JIA genetic risk loci, the majority of which are located in non-coding regions, where transcription is regulated and coordinated on a genome-wide basis. We examined human neutrophils and CD4 primary T cells to identify genes and functional elements located within those risk loci...
March 14, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28288653/inflammatory-bowel-disease-following-anti-interleukin-1-treatment-in-systemic-juvenile-idiopathic-arthritis
#12
Boris Hügle, Fabian Speth, Johannes-Peter Haas
BACKGROUND: Inflammatory bowel disease can develop in the context of some rheumatic diseases in childhood, including juvenile idiopathic arthritis (JIA). Inflammatory bowel disease (IBD) is frequently associated with other immune-mediated diseases; however, systemic onset JIA (sJIA) has not previously been connected to IBD. Treatment of sJIA has significantly changed in recent years, possibly causing changes in inflammatory patterns. Therefore, data from the German Center for Pediatric and Adolescent Rheumtology from 2010 until 2015 were analyzed by retrospective chart review...
March 14, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28287946/mr-imaging-of-the-temporomandibular-joint-in-juvenile-idiopathic-arthritis-technique-and-findings
#13
María Navallas, Emilio J Inarejos, Estíbaliz Iglesias, Gui Youn Cho Lee, Natalia Rodríguez, Jordi Antón
The term juvenile idiopathic arthritis (JIA) encompasses a group of arthritides of unknown cause that begin before 16 years of age and last for at least 6 weeks. Temporomandibular joint (TMJ) involvement has been described in up to 87% of children with JIA and has been associated with all JIA subtypes. TMJ involvement is difficult to detect clinically. In one study, 71% of JIA patients with active TMJ synovitis were asymptomatic and 63% had normal physical examination results. Moreover, the main growth center of the mandible is located in the condyle, separated from the joint space by only a thin layer of fibrocartilage...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28283733/high-sensitive-crp-as-a-predictive-marker-of-long-term-outcome-in-juvenile-idiopathic-arthritis
#14
Mikel Alberdi-Saugstrup, Marek Zak, Susan Nielsen, Troels Herlin, Ellen Nordal, Lillemor Berntson, Anders Fasth, Marite Rygg, Klaus Müller
To evaluate whether C-reactive protein (CRP), including variation within the normal range, is predictive of long-term disease outcome in Juvenile Idiopathic Arthritis (JIA). Consecutive patients with newly diagnosed JIA were included prospectively from defined geographic areas of the Nordic countries from 1997 to 2000. Inclusion criteria were availability of a baseline serum sample within 12 months after disease onset and 8-year clinical assessment data. Systemic onset JIA was not included. CRP was measured by high-sensitive ELISA (detection limit of 0...
March 10, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28283723/intravoxel-incoherent-motion-magnetic-resonance-imaging-of-the-knee-joint-in-children-with-juvenile-idiopathic-arthritis
#15
Fabian Hilbert, Annette Holl-Wieden, Alexander Sauer, Herbert Köstler, Henning Neubauer
BACKGROUND: MRI of synovitis relies on use of a gadolinium-based contrast agent. Diffusion-weighted MRI (DWI) visualises thickened synovium but is of limited use in the presence of joint effusion. OBJECTIVE: To investigate the feasibility and diagnostic accuracy of diffusion-weighted MRI with intravoxel incoherent motion (IVIM) for diagnosing synovitis in the knee joint of children with juvenile idiopathic arthritis. MATERIALS AND METHODS: Twelve consecutive children with confirmed or suspected juvenile idiopathic arthritis (10 girls, median age 11 years) underwent MRI with contrast-enhanced T1-weighted imaging and DWI at 1...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28282424/mental-health-and-adjustment-to-juvenile-idiopathic-arthritis-level-of-agreement-between-parent-and-adolescent-reports-according-to-strengths-and-difficulties-questionnaire-and-adolescent-outcomes-questionnaire
#16
Ewa Misterska, Dominika Kaminiarczyk-Pyzałka, Karolina Adamczak, Katarzyna A Adamczyk, Marek Niedziela, Maciej Głowacki, Jakub Głowacki
The aims of this study were threefold. Firstly, to analyze the psychometric properties of the Polish-language Pediatric Outcomes Data Collection Instrument (PODCI) questionnaire in the self-report Adolescent Outcomes Questionnaire (adolescents, 11-18 years of age) and in the parent-report Adolescent Outcomes Questionnaire (completed by a parent or guardian of an adolescent aged 11-18 years). Secondly, to determine the level of agreement between parents and adolescents in rating dysfunction in juvenile idiopathic arthritis (JIA) and thirdly, to examine associations between psychological adjustments of patients to JIA and disease as well as their socio-demographic characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28277884/investigational-drugs-for-treatment-of-juvenile-idiopathic-arthritis
#17
Angela Mauro, Donato Rigante, Rolando Cimaz
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. The improvement of knowledge about the pathogenetic mechanisms of JIA and advances in the understanding of pathways linking inflammation and autoimmunity and functions of multiple transcription factors have translated into new drug development for a tailored treatment directed to specific subpopulations of JIA patients. Areas covered: This review provides a digest of new investigational drugs which are currently or have been recently tested for treatment of JIA, and highlights some early phase clinical trials on rilonacept, givinostat, daclizumab, tofacitinib, and sarilumab...
March 12, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28277841/safety-of-tocilizumab-in-the-treatment-of-juvenile-idiopathic-arthritis
#18
Ricardo Machado Xavier, Sandra Helena Machado
Tocilizumab (TCZ) is a recombinant humanized monoclonal antibody and IL-6 receptor antagonist, currently approved for the treatment of systemic juvenile idiopathic arthritis (sJIA) and polyarticular juvenile idiopathic arthritis (pJIA) in children aged 2 years or older refractory to conventional treatment. The most common adverse events in patients treated with TCZ were infections, especially in the respiratory tract. The most frequent laboratory abnormalities were altered liver function, neutropenia and elevated cholesterol levels...
March 6, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28277284/effects-of-the-use-of-growth-hormone-in-children-and-adolescents-with-juvenile-idiopathic-arthritis-a-systematic-review
#19
Renan Bazuco Frittoli, Barbara Sugui Longui, Amanda Meireles Silva, Antônio de Azevedo Barros Filho, Maria Ângela Reis de Góes Monteiro, Simone Appenzeller
INTRODUCTION: Children with Juvenile Idiopathic Arthritis (JIA) often have impaired growth and short stature. There is evidence that the therapeutic use of growth hormone (GH) is useful and safe in these patients. OBJECTIVE: To analyze the effects of GH use in patients with JIA. METHOD: A systematic review of the literature over the last 18 years in Medline and Embase databases. The criteria were analyzed independently by the researchers. We used the following keywords: "growth hormone", "arthritis, juvenile", "arthritis, rheumatoid", "child" and "adolescent"...
July 9, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28277255/recommendations-for-the-use-of-ultrasound-and-magnetic-resonance-in-patients-with-spondyloarthritis-including-psoriatic-arthritis-and-patients-with-juvenile-idiopathic-arthritis
#20
Jacqueline Uson, Estibaliz Loza, Ingrid Möller, Carlos Acebes, Jose Luis Andreu, Enrique Batlle, Ángel Bueno, Paz Collado, Juan Manuel Fernández-Gallardo, Carlos González, Mercedes Jiménez Palop, María Pilar Lisbona, Pilar Macarrón, Joan Maymó, Jose Antonio Narváez, Victoria Navarro-Compán, Jesús Sanz, M Piedad Rosario, Esther Vicente, Esperanza Naredo
OBJECTIVE: To develop evidence-based recommendations on the use of ultrasound (US) and magnetic resonance imaging in patients with spondyloarthritis, including psoriatic arthritis, and juvenile idiopathic arthritis. METHODS: Recommendations were generated following a nominal group technique. A panel of experts (15 rheumatologists and 3 radiologists) was established in the first panel meeting to define the scope and purpose of the consensus document, as well as chapters, potential recommendations and systematic literature reviews (we used and updated those from previous EULAR documents)...
October 27, 2016: Reumatología Clinica
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