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Juvenil idiopathic arthritis

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https://www.readbyqxmd.com/read/28732134/physical-functioning-pain-and-health-related-quality-of-life-in-adults-with-juvenile-idiopathic-arthritis-a-longitudinal-30-year-follow-up-study
#1
Anita Tollisen, Anne M Selvaag, Hanne A Aulie, Vibke Lilleby, Astrid Aasland, Anners Lerdal, Berit Flatø
OBJECTIVES: To describe physical functioning, pain, and health-related quality of life (HRQOL) in adults with Juvenile idiopathic arthritis (JIA), investigate changes over time, and identify predictors of poorer HRQOL after 30 years of disease duration. METHODS: Patients (N=176) clinically examined after 15 years were reassessed with the Health Assessment Questionnaire Disability Index (HAQ-DI), Visual Analogue Scale Pain (VAS pain) and Medical Outcome Study 36-item Short Form (SF-36) after 23 and 30 years...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28730667/role-of-plasma-exchange-leukocytapheresis-and-plasma-diafiltration-in-management-of-refractory-macrophage-activation-syndrome
#2
Noriko Kinjo, Kazuya Hamada, Chika Hirayama, Masaki Shimizu
Macrophage activation syndrome (MAS) is a life-threating complication of systemic juvenile idiopathic arthritis (s-JIA). Steroid and cyclosporine (CsA) are effective for MAS, but, treatment for steroid- and CsA-resistant patients is still challenging. We report the case of steroid and CsA resistant s-JIA associated MAS misdiagnosed as Kawasaki disease (KD), who was successfully treated with the combination of plasma exchange (PE) and leukocytapheresis (LCAP) followed by plasma diafiltration (PDF). PE + LCAP effectively removed proinflammatory cytokines and reduced the number of peripheral white blood cells...
July 21, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28729171/exercise-therapy-in-juvenile-idiopathic-arthritis-a-systematic-review-and-meta-analysis
#3
REVIEW
Gregor Kuntze, Colleen Nesbitt, Jackie L Whittaker, Alberto Nettel-Aguirre, Clodagh Toomey, Shane Esau, Patricia K Doyle-Baker, Jena Shank, Julia Brooks, Susanne Benseler, Carolyn A Emery
OBJECTIVE: To conduct a systematic review to evaluate the efficacy of exercise interventions on improving outcomes across domains of functioning and disability in children and adolescents with Juvenile Idiopathic Arthritis (JIA). DATA SOURCES: Seven electronic databases were systematically searched up to December 2016. STUDY SELECTION: Original data, analytic prospective design, physical therapy led exercise intervention evaluation, children and adolescents with JIA, and assessment of functional, structural, activity, participation or quality of life outcomes...
July 17, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28725955/biologics-in-juvenile-idiopathic-arthritis-a-narrative-review
#4
REVIEW
Federica Vanoni, Francesca Minoia, Clara Malattia
In the past years, pediatric rheumatology has seen a revolution in the treatments for rheumatic diseases, particularly juvenile idiopathic arthritis. Even if nonsteroidal anti-inflammatory drugs (NSAID), intra-articular corticosteroids (IAC) injections, and methotrexate remain the mainstay of the treatment for JIA patients, in aggressive disease, these treatments may be not sufficient to reach disease remission and to prevent long-term disability. Comprehension of immunological mechanisms involved in the pathogenesis of the diseases allowed to conceive new drugs targeting specific steps of the immune response...
July 20, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28721859/immunogenicity-and-safety-of-the-inactivated-hepatitis-a-vaccine-in-children-with-juvenile-idiopathic-arthritis-on-methotrexate-treatment-a-matched-case-control-study
#5
Despoina N Maritsi, Susan E Coffin, Ioanna Argyri, George Vartzelis, Nick Spyridis, Maria N Tsolia
OBJECTIVES: To describe the immunogenicity and side effects of immunisation against hepatitis A virus (HAV) in JIA patients on methotrexate treatment, who have not been previously exposed to HAV. METHODS: Case-control study performed in JIA patients and healthy controls matched on age and gender. The subjects received two doses of inactivated anti-HAV vaccine (720 mIU/ml) intramuscularly at 0 and 6 months. Seroconversion, seroprotection rates and anti-HAV-IgG titres were measured at 1, 7 and 18 months...
July 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28719732/genome-wide-association-meta-analysis-reveals-novel-juvenile-idiopathic-arthritis-susceptibility-loci
#6
Laura A McIntosh, Miranda C Marion, Marc Sudman, Mary E Comeau, Mara L Becker, John F Bohnsack, Tasha E Fingerlin, Thomas A Griffin, J Peter Haas, Daniel J Lovell, Lisa A Maier, Peter A Nigrovic, Sampath Prahalad, Marilynn Punaro, Carlos D Rosé, Carol A Wallace, Carol A Wise, Halima Moncrieffe, Timothy D Howard, Carl D Langefeld, Susan D Thompson
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and has a strong genomic component. To date, JIA genetic association studies have had limited sample sizes, used heterogeneous patient populations, or included only candidate regions. This study focuses on identifying new associations among oligoarticular and polyarticular rheumatoid factor negative (RF(-) ) JIA, which are clinically similar and the most prevalent JIA disease subtypes. METHODS: Three cohorts totaling 2,751 oligoarticular and polyarticular RF(-) JIA cases were genotyped on the Affymetrix Genome-Wide SNP Array 6...
July 18, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28718441/is-intra-articular-steroid-injection-to-the-temporomandibular-joint-for-juvenile-idiopathic-arthritis-more-effective-and-efficient-when-performed-with-image-guidance
#7
Cory M Resnick, Pouya M Vakilian, Leonard B Kaban, Zachary S Peacock
PURPOSE: To compare short-term outcomes and procedure times for intra-articular steroid injection (IASI) to the temporomandibular joint (TMJ) with and without the use of intraoperative image guidance for patients with juvenile idiopathic arthritis (JIA). MATERIALS AND METHODS: This is a retrospective study of children with JIA who underwent TMJ IASI at Boston Children's Hospital (Boston, MA). Patients were divided into groups according to IASI technique: 1) "landmark" group if performed by an oral and maxillofacial surgeon using an anatomic landmark technique with no intraoperative image guidance or 2) "image-guided" group if performed by an interventional radiologist using intraoperative ultrasound and computed tomography...
April 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713058/regression-of-unusual-optic-disk-neovascularization-after-adalimumab-in-a-case-of-juvenile-idiopathic-arthritis-related-uveitis
#8
Emanuela Interlandi, Loredana Latanza, Francesco Pellegrini, Carlos Pavesio
No abstract text is available yet for this article.
July 13, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28711144/genetics-of-juvenile-idiopathic-arthritis
#9
REVIEW
Aimee O Hersh, Sampath Prahalad
Juvenile idiopathic arthritis (JIA) affects approximately 1 in 1000 US children. The cause of JIA is most likely multifactorial and due to an interplay of genetics and environmental factors. This article summarizes the known genetic risk factors for JIA that have been identified, and in some cases replicated, using a variety of methods, including genomewide association and candidate gene association studies. A brief discussion regarding pharmacogenomics and studies to data linking genetics to treatment response and outcomes is included...
August 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/28696851/us-evaluation-of-juvenile-idiopathic-arthritis-and-osteoarticular-infection
#10
Jie C Nguyen, Kenneth S Lee, Mahesh M Thapa, Humberto G Rosas
Juvenile idiopathic arthritis (JIA) and osteoarticular infection can cause nonspecific articular and periarticular complaints in children. Although contrast material-enhanced magnetic resonance imaging is the reference standard imaging modality, musculoskeletal ultrasonography (US) is emerging as an important adjunct imaging modality that can provide valuable information relatively quickly without use of radiation or the need for sedation. However, diagnostic accuracy requires a systemic approach, familiarity with various US techniques, and an understanding of maturation-related changes...
July 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28695182/adolescent-total-knee-arthroplasty
#11
John R Martin, Alan K Sutak, Todd A Milbrandt, Valerie A Martin, Robert T Trousdale
BACKGROUND: Management of adolescent patients with end-stage arthritis is challenging. Nonoperative treatments may be ineffective and total knee arthroplasty (TKA) is rarely performed. Currently, minimal long-term data are available on the outcomes in this patient population. Our goal was to describe TKA for patients with end-stage arthritis who were aged 20 years and younger. METHODS: The Joint Registry at our institution was used to identify 19 patients (29 TKAs) aged 20 years and younger that underwent a primary TKA...
June 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28690841/new-frontiers-in-the-treatment-of-systemic-juvenile-idiopathic-arthritis
#12
REVIEW
Susan Canny, Elizabeth Mellins
Systemic juvenile idiopathic arthritis (sJIA) and its most significant complication, macrophage activation syndrome (MAS), have traditionally been treated with steroids and non-steroidal anti-inflammatory medications. However, the introduction of biologic medications that inhibit specific cytokines, such interleukins 1 and 6, has changed the treatment paradigm for sJIA patients. In this review, we discuss the therapies currently used in the treatment of sJIA as well as novel targets and approaches under consideration, including mesenchymal stromal cell therapy and JAK inhibitors...
2017: F1000Research
https://www.readbyqxmd.com/read/28686532/management-of-hydrocephalus-associated-with-autoimmune-diseases-a-series-of-19-cases
#13
Baitao Ma, Hao Wu, Hexiang Yin, Jianbo Chang, Li Wang, Renzhi Wang, Wenbin Ma, Yongning Li, Jian Guan, Jinjing Liu, Junji Wei
OBJECTIVES: To analyze the diagnosis and treatment of hydrocephalus associated with autoimmune diseases and to explore the possible mechanism of hydrocephalus in these patients. METHODS: A retrospective case series study was conducted at Peking Union Medical College Hospital, Beijing, China. Files were retrieved from the hospital archives by screening records from Jan 1990 to Jan 2016. Medical records were screened for data regarding (1) the number of patients diagnosed with hydrocephalus associated with autoimmune diseases, (2) the clinical manifestation of hydrocephalus associated with autoimmune disease, and (3) the outcomes of these patients treated with medication or ventriculoperitoneal shunt (VPS)...
July 7, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28686088/changing-epidemiology-of-aa-amyloidosis-clinical-observations-over-25-years-at-a-single-national-referral-centre
#14
Thirusha Lane, Jennifer H Pinney, Janet A Gilbertson, David F Hutt, Dorota M Rowczenio, Shameem Mahmood, Sajitha Sachchithanantham, Marianna Fontana, Taryn Youngstein, Candida C Quarta, Ashutosh D Wechalekar, Julian D Gillmore, Philip N Hawkins, Helen J Lachmann
OBJECTIVE: Systemic AA amyloidosis is a serious complication of chronic inflammation; however, there are relatively few published data on its incidence. We investigated the changing epidemiology of AA amyloidosis over a 25-year period at a single national referral centre. METHODS: We conducted a retrospective study of all patients diagnosed with AA amyloidosis who had attended the centre between 1990 and 2014 inclusive. Six hundred and twenty-five patients were studied in three cohorts: C1: 1990-1997; C2: 1998-2006; C3: 2007-2014...
July 7, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28680339/exceptional-manifestation-of-polyautoimmunity-in-a-very-young-girl-a-case-report
#15
Agnieszka Mroczkowska-Juchkiewicz, Jacek Postępski, Edyta Olesińska, Paulina Krawiec, Elżbieta Pac-Kożuchowska
Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. The exact pathogenic mechanisms responsible for the coexistence of distinct autoimmune diseases within an individual have not been clearly explained. We report a case of a very young girl with the extremely rare co-existence of four distinct autoimmune diseases i.e. juvenile idiopathic arthritis, type 1 diabetes mellitus, coeliac disease and autoimmune hepatitis, recognized based on validated international classification criteria...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28666454/fluorescence-optical-imaging-and-musculoskeletal-ultrasonography-in-juvenile-idiopathic-polyarticular-disease-before-and-during-antirheumatic-treatment%C3%A2-a-multicenter-non-interventional-diagnostic-evaluation
#16
Ariane Klein, Georg Werner Just, Stephanie Gabriele Werner, Prasad T Oommen, Kirsten Minden, Ingrid Becker, Hans-Eckhard Langer, Dirk Klee, Gerd Horneff
BACKGROUND: Valid detection of inflamed joints is essential for correct classification, therapeutic decisions, prognosis and assessment of treatment efficacy in juvenile idiopathic arthritis (JIA). Fluorescence optical imaging (FOI) enables visualization of inflammation in arthritis of finger and hand joints and might be used for monitoring. METHODS: A 24-week observational study in polyarticular JIA patients newly starting treatment with methotrexate or an approved biologic was performed in three centers...
June 30, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28666379/risks-of-serious-infections-in-children-treated-with-biologic-response-modifying-drugs-bacterial-infection-risk-in-children-with-juvenile-idiopathic-arthritis
#17
https://www.readbyqxmd.com/read/28663002/autoantibodies-in-juvenile-onset-myositis-their-diagnostic-value-and-associated-clinical-phenotype-in-a-large-uk-cohort
#18
Sarah L Tansley, Stefania Simou, Gavin Shaddick, Zoe E Betteridge, Beverley Almeida, Harsha Gunawardena, Wendy Thomson, Michael W Beresford, Angela Midgley, Francesco Muntoni, Lucy R Wedderburn, Neil J McHugh
OBJECTIVES: Juvenile myositis is a rare and heterogeneous disease. Diagnosis is often difficult but early treatment is important in reducing the risk of associated morbidity and poor outcomes. Myositis specific autoantibodies have been described in both juvenile and adult patients with myositis and can be helpful in dividing patients into clinically homogenous groups. We aimed to explore the utility of myositis specific autoantibodies as diagnostic and prognostic biomarkers in patients with juvenile-onset disease...
June 26, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28654500/commentary-on-physical-exercise-and-physical-activity-for-children-and-adolescents-with-juvenile-idiopathic-arthritis-a-literature-review
#19
Patrick van der Torre, Marco van Brussel
No abstract text is available yet for this article.
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28654499/physical-exercise-and-physical-activity-for-children-and-adolescents-with-juvenile-idiopathic-arthritis-a-literature-review
#20
Hilenia Catania, Viola Fortini, Rolando Cimaz
PURPOSE: This is a review of studies that investigate the efficacy of exercise therapy and physical activity for children with juvenile idiopathic arthritis since the 2008 Cochrane Review. METHOD: Studies were identified that investigated the use of physical activity and exercise therapy in the treatment of children and adolescents with juvenile idiopathic arthritis, excluding the Cochrane Review. Two reviewers individually analyzed the results of the search to determine the eligibility of studies...
July 2017: Pediatric Physical Therapy
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