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Juvenil idiopathic arthritis

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https://www.readbyqxmd.com/read/29041986/fluorescence-optical-imaging-in-pediatric-patients-with-inflammatory-and-non-inflammatory-joint-diseases-a-comparative-study-with-ultrasonography
#1
Marisa Christin Beck, Anne-Marie Glimm, Sarah Ohrndorf, Kirsten Minden, Ralf Trauzeddel, Stephanie Gabriele Werner, Gerd Horneff, Marina Backhaus, Gerd Rüdiger Burmester, Tilmann Kallinich, Hermann Girschick, Jens Klotsche
BACKGROUND: Valid detection of arthritis is essential in differential diagnosis of joint pain. Indocyanin green (ICG)-enhanced fluorescence optical imaging (FOI) is a new imaging method that visualizes inflammation in wrist and finger joints. Objectives of this study were to compare FOI with ultrasonography (US, by gray-scale (GS) and power Doppler (PD)) and clinical examination (CE) and to estimate the predictive power of FOI for discrimination between inflammatory and non-inflammatory juvenile joint diseases...
October 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29040144/surgical-treatment-of-dentofacial-deformities-caused-by-juvenile-idiopathic-arthritis
#2
Patricia Stoor, Zlatan Hodzic, Sirpa Arte
The purpose of our retrospective study was to evaluate the results of orthognathic treatment, distraction osteogenesis, and/or prosthetic reconstruction of the temporomandibular joints in patients with juvenile idiopathic arthritis (JIA).Twelve patients with severely affected temporomandibular joints (TMJs) and reduced ramus height were treated with mandibular advancement with orthognathic surgery (11) and additional bilateral or unilateral mandibular ramus distraction (3) or additional bilateral or unilateral prosthetic reconstruction of the TMJ (3)...
October 16, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29037901/hla-drb1-alleles-and-juvenile-idiopathic-arthritis-diagnostic-clues-emerging-from-a-meta-analysis
#3
REVIEW
Annalisa De Silvestri, Cristina Capittini, Dimitri Poddighe, Gian Luigi Marseglia, Luca Mascaretti, Elena Bevilacqua, Annamaria Pasi, Miryam Martinetti, Carmine Tinelli
Juvenile Idiopathic Arthritis (JIA) is characterized with a variable pattern of articular involvement and systemic symptoms and, thus, it has been classified in several subtypes. Genetic predisposition to JIA is mainly due to HLA class II molecules (HLA-DRB1, HLA-DPB1), although HLA class I molecules and non-HLA genes have been implicated, too. Here, we carried out a meta-analysis on selected studies designed to assess HLA genetic background of JIA patients, compared to healthy controls and, particularly, we focused our attention on HLA-DRB1...
October 13, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29037325/erratum-to-effects-of-the-use-of-growth-hormone-in-children-adolescents-with-juvenile-idiopathic-arthritis-a-systematic-review-rev-bras-reumatol-2017-57-2-100-106
#4
Renan Bazuco Frittoli, Barbara Sugui Longhi, Amanda Meireles Silva, Antônio de Azevedo Barros Filho, Maria Ângela Reis de Góes Monteiro, Simone Appenzeller
No abstract text is available yet for this article.
September 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29037310/latent-tuberculosis-infection-screening-in-juvenile-idiopathic-arthritis-patients-preceding-anti-tnf-therapy-in-a-tuberculosis-high-risk-country
#5
Juliana Barbosa Brunelli, Karina Rossi Bonfiglioli, Clovis A Silva, Katia Tomie Kozu, Claudia Goldenstein-Schainberg, Eloisa Bonfa, Nadia Emi Aikawa
OBJECTIVES: To evaluate, in an endemic country, the long-term efficacy of latent tuberculosis infection (LTBI) screening and primary prophylaxis in patients with JIA receiving TNF blockers. METHODS: This was a retrospective cohort that included JIA patients eligible to anti-TNF therapy. Patients were screened for LTBI prior to anti-TNF using tuberculin skin test (TST), chest X-ray and history of exposure to TB. Subjects were regularly followed at 2-month intervals...
September 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29031228/peptide-based-electrochemical-biosensor-for-juvenile-idiopathic-arthritis-detection
#6
V R Rodovalho, G R Araujo, E R Vaz, C Ueira-Vieira, L R Goulart, J M Madurro, A G Brito-Madurro
Juvenile idiopathic arthritis (JIA) is a wide group of diseases, characterized by synovial inflammation and joint tissue damage. Due to the delay in the implementation of biomarkers into clinical practice and the association with severe sequels, there is an imperative need for new JIA diagnosis strategies. Electrochemical biosensors based on screen-printed electrodes and peptides are promising alternatives for molecular diagnosis. In this work, a novel biosensor for detecting juvenile idiopathic arthritis (JIA) was developed based on the immobilization of the PRF+1 mimetic peptide, as recognition biological element, on the surface of screen-printed carbon electrode...
October 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29029616/short-term-effectiveness-and-experiences-of-a-peer-guided-web-based-self-management-intervention-for-young-adults-with-juvenile-idiopathic-arthritis
#7
Judy Ammerlaan, Harmieke van Os-Medendorp, Nienke de Boer-Nijhof, Lieske Scholtus, Aike A Kruize, Philomine van Pelt, Berent Prakken, Hans Bijlsma
BACKGROUND: A web-based self-management intervention guided by peer-trainers was developed to support young adults' self-management in coping with Juvenile Idiopathic Arthritis (JIA). To investigate its effectiveness, a randomized controlled trial (RCT) was conducted. In addition, the content of the chat and participants' goals were studied to identify underlying processes. METHODS: An RCT with a six-month follow up period was conducted among 72 young adults with JIA, aged between 16 and 25 years old, randomly assigned to the intervention or to the usual care control group...
October 13, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29029101/growth-outcomes-after-gh-therapy-of-patients-given-long-term-corticosteroids-for-juvenile-idiopathic-arthritis
#8
Hélène David, Camille Aupiais, Baptiste Louveau, Pierre Quartier, Evelyne Jacqz-Aigrain, Jean-Claude Carel, Dominique Simon
Context: GH therapy may improve statural growth outcomes in patients with severe juvenile idiopathic arthritis (JIA). Objectives: To evaluate the effect of GH treatment on adult height and to identify determinants of growth outcomes in JIA. Design and patients: Data from 58 JIA patients, including 53 given GH, enrolled in three prospective clinical trials between 1997 and 2002 were analyzed. Intervention: GH [0.056 mg/kg/d (IQR, 0...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29027570/are-we-right-to-consider-mesenchymal-stem-cells-to-be-a-new-perspective-for-patients-with-juvenile-idiopathic-arthritis
#9
REVIEW
Krzysztof Orczyk, Elzbieta Smolewska
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood. Up to 50% of patients are resistant to standard therapy, which includes non-steroid anti-inflammatory drugs, corticosteroids, disease-modifying anti-rheumatic drugs and biologic therapies. Intra-articular injection of mesenchymal stem cells (MSCs) is proposed as a new approach to JIA treatment. MSCs can modulate inflammation via mechanisms of both adaptive and innate immune response. They are able to inhibit T and B cell proliferation, promote regulatory T cells, suppress the maturation of dendritic cells, stimulate macrophage differentiation into M2 phenotype and reduce effectiveness of natural killer cells...
October 13, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29025853/concomitant-administration-of-methotrexate-does-not-improve-efficacy-of-intra-articular-joint-injections-in-patients-with-oligoarticular-juvenile-idiopathic-arthritis
#10
William J Coles, Eslam Al-Abadi
No abstract text is available yet for this article.
October 12, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29025422/readout-segmented-multi-shot-diffusion-weighted-mri-of-the-knee-joint-in-patients-with-juvenile-idiopathic-arthritis
#11
Alexander Sauer, Mengxia Li, Annette Holl-Wieden, Thomas Pabst, Henning Neubauer
BACKGROUND: Diffusion-weighted MRI has been proposed as a new technique for imaging synovitis without intravenous contrast application. We investigated diagnostic utility of multi-shot readout-segmented diffusion-weighted MRI (multi-shot DWI) for synovial imaging of the knee joint in patients with juvenile idiopathic arthritis (JIA). METHODS: Thirty-two consecutive patients with confirmed or suspected JIA (21 girls, median age 13 years) underwent routine 1.5 T MRI with contrast-enhanced T1w imaging (contrast-enhanced MRI) and with multi-shot DWI (RESOLVE, b-values 0-50 and 800 s/mm(2))...
October 12, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29024575/genetics-and-the-classification-of-arthritis-in-adults-and-children
#12
REVIEW
Peter A Nigrovic, Soumya Raychaudhuri, Susan D Thompson
Current classification of primary inflammatory arthritis begins from the assumption that adults and children are different. No form of juvenile idiopathic arthritis bears the same name as an adult arthritis, a nomenclature gap with implications for both clinical care and research. Recent genetic data question this adult/pediatric divide, revealing instead broad patterns that span the age spectrum. Combining these genetic patterns with demographic and clinical data, we propose that inflammatory arthritis segregates into four main clusters, largely irrespective of pediatric or adult onset: seropositive, seronegative (likely including a distinct group that usually begins in early childhood), spondyloarthritis and systemic...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29022136/aortic-carotid-intima-media-thickness-and-flow-mediated-dilation-as-markers-of-early-atherosclerosis-in-a-cohort-of-pediatric-patients-with-rheumatic-diseases
#13
Emanuela Del Giudice, Anna Dilillo, Luciana Tromba, Giuseppe La Torre, Sara Blasi, Fabrizio Conti, Franca Viola, Salvatore Cucchiara, Marzia Duse
The aims of this study were to identify the presence of endothelial dysfunction as a marker of early atherosclerosis by measuring aortic and carotid intimal-medial thickness (aIMT and cIMT) and flow-mediated dilation (FMD) and their correlation with traditional and no traditional risk factors for atherosclerosis in children with rheumatic diseases. Thirty-nine patients (mean age 15.3 ± 5.7 years), 23 juvenile idiopathic arthritis, 9 juvenile spondyloarthropathies, 7 connective tissue diseases (mean disease duration and onset respectively 5 ± 3...
October 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29019476/parenting-a-child-with-juvenile-idiopathic-arthritis-orofacial-pain-and-dysfunction-a-qualitative-study
#14
Eva Leksell, Ulrika Hallberg, AnnaCarin Horne, Malin Ernberg, Britt Hedenberg-Magnusson
AIMS: To deepen knowledge of how parents of children diagnosed with juvenile idiopathic arthritis (JIA) perceive the orofacial manifestations of the disease, its treatments, and their encounters with dental care providers. METHODS: A total of 15 interviews with parents of JIA patients (3 to 16 years old) with orofacial pain were analyzed according to classic grounded theory. RESULTS: The main problem was identified as controlling an unpredictable life situation that includes a child with JIA...
October 10, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29018906/the-performance-of-classification-criteria-for-juvenile-spondyloarthropathies
#15
Amra Adrovic, Metin Sezen, Kenan Barut, Sezgin Sahin, Cengizhan Acikel, Erkan Demirkaya, Ozgur Kasapcopur
Juvenile spondyloarthropathies (JSpA) are a group of rheumatologic diseases with a disease onset before 16; characterized with enthesitis, lower extremity oligoarthritis, involvement of the axial skeleton and HLA B27 positivity. The diversity of classification criteria along with the phenotype heterogeneity makes the classification of JSpA challenging. The aim of our study was to evaluate the performance of the pre-determined and recently proposed classification criteria for JSpA. The study group consisted of 113 patients with JSpA and 150 patients with juvenile idiopathic arthritis (JIA)...
October 10, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28990337/the-prioritization-of-symptom-beliefs-over-illness-beliefs-the-development-and-validation-of-the-pain-perception-questionnaire-for-young-people
#16
Daniela Ghio, Wendy Thomson, Rachel Calam, Fiona Ulph, Eileen M Baildam, Kimme Hyrich, Lis Cordingley
OBJECTIVES: To investigate the suitability of the revised Illness Perception Questionnaire (IPQ-R) for use with adolescents with a long-term pain condition and to validate a new questionnaire for use with this age group. DESIGN: A three-phase mixed-methods study. METHODS: Phase 1 comprised in-depth qualitative analyses of audio-recorded cognitive interviews with 20 adolescents with juvenile idiopathic arthritis who were answering IPQ-R items...
October 9, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28990043/%C3%AE-he-genetics-of-juvenile-idiopathic-arthritis-searching-for-new-susceptibility-loci
#17
Maria I Zervou, Despoina G Dimopoulou, Elias Eliopoulos, Maria Trachana, Polyxeni Pratsidou-Gkertsi, Athena Andreou, Prodromos Sidiropoulos, Demetrios A Spandidos, Alexandros Garyfallos, George N Goulielmos
Juvenile idiopathic arthritis (JIA) is an autoimmune disease that is characterized by persistent chronic arthritis and affected by genetic and environmental factors. Different genetic variations have been reported as risk factors for JIA. However, given that many results could not be replicated in individuals of different ancestral origin, it was assumed that heterogeneous genetic factors are involved in this disease. In the present study, we analyzed three single nucleotide polymorphisms (SNPs), namely PTPRC (rs10919563), TYK2 (rs34536443) and PRKCQ (rs4750316), which were found to be associated with JIA in previous studies...
October 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28985804/adult-patients-with-uveitis-associated-with-juvenile-idiopathic-arthritis-a-retrospective-review
#18
Anton M Kolomeyer, Elliot S Crane, Yufei Tu, Dan Liu, David S Chu
OBJECTIVE: To describe clinical characteristics and outcomes of adults with uveitis associated with juvenile idiopathic arthritis (JIA). METHODS: Retrospective chart review from 2001 to 2014 of adult patients with JIA and follow-up ≥2 months. Outcome measures included visual acuity, intraocular pressure (IOP), inflammation grade, ocular findings/complications, immunosuppressive therapies, and surgeries. RESULTS: Nineteen patients were included (95% female, 84% bilateral uveitis, 47% anterior uveitis)...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28980895/systemic-onset-juvenile-idiopathic-arthritis-and-incomplete-kawasaki-disease-may-belong-to-a-single-clinical-syndrome-within-a-spectrum-of-severity
#19
Seung Beom Han, Soo Young Lee
No abstract text is available yet for this article.
October 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28978993/juvenile-idiopathic-arthritis-evidence-of-gut-driven-inflammation-in-new-jia
#20
Sarah Onuora
No abstract text is available yet for this article.
October 5, 2017: Nature Reviews. Rheumatology
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