keyword
https://read.qxmd.com/read/38537223/a-systems-framework-for-investigating-the-roles-of-multiple-transporters-and-their-impact-on-drug-resistance
#1
JOURNAL ARTICLE
Manfredi di San Germano, J Krishnan
Efflux transporters are a fundamental component of both prokaryotic and eukaryotic cells, play a crucial role in maintaining cellular homeostasis, and represent a key bridge between single cell and population levels. From a biomedical perspective, they play a crucial role in drug resistance (and especially multi-drug resistance, MDR) in a range of systems spanning bacteria and human cancer cells. Typically, multiple efflux transporters are present in these cells, and the efflux transporters transport a range of substrates (with partially overlapping substrates between transporters)...
January 23, 2024: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://read.qxmd.com/read/38537212/complete-resolution-of-locally-advanced-prostate-cancer-after-molecular-endoradiotherapy-with-177lu-psma
#2
JOURNAL ARTICLE
Mohsen Beheshti, Reza Vali, Soroush Zarehparvar Moghadam, HamidReza Amini, Masoumeh Hakiminejad, GhasemAli Divband
A 76-year-old man with castration-resistant prostate cancer underwent 68Ga-prostate-specific membrane antigen (PSMA) PET/CT for restaging. A large PSMA-avid tumor with invasion to adjacent organs was noted causing gross hematuria and symptomatic anemia. Two cycles of 177Lu-PSMA were administered, and the patient showed significant reduction of hematuria as well as declining in PSA levels. 177Lu-PSMA therapy can be a good treatment option in patients with locally invasive tumors.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537162/advancing-bone-targeted-drug-delivery-leveraging-biological-factors-and-nanoparticle-designs-to-improve-therapeutic-efficacy
#3
JOURNAL ARTICLE
Baixue Xiao, Marian A Ackun-Farmmer, Emmanuela Adjei-Sowah, Yuxuan Liu, Indika Chandrasiri, Danielle S W Benoit
Designing targeted drug delivery systems to effectively treat bone diseases ranging from osteoporosis to nonunion bone defects remains a significant challenge. Previously, nanoparticles (NPs) self-assembled from diblock copolymers of poly(styrene- alt -maleic anhydride)- b -poly(styrene) (PSMA- b -PS) delivering a Wnt agonist were shown to effectively target bone and improve healing via the introduction of a peptide with high affinity to tartrate-resistant acid phosphatase (TRAP), an enzyme deposited by the osteoclasts during bone remodeling...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38537145/identification-of-two-novel-qtl-for-fusarium-head-blight-resistance-in-german-wheat-cultivar-centrum
#4
JOURNAL ARTICLE
Hui Ren, Xin Zhang, Yibo Zhang, Ziyang Zhang, Muzi Cheng, Lu Zhang, Xiangxue Zhang, Chunchun Li, Jiangli Duan, Chuanliang Zhang, Mingjie Xiang, Shengjie Liu, Chengzhi Jiang, Qingdong Zeng, Jianhui Wu, Zhensheng Kang, Zujun Yang, Chunlian Li, Shuo Huang, Dejun Han
Fusarium head blight (FHB) is a devastating disease that occurs in warm and humid environments. The German wheat Centrum has displayed moderate to high levels of FHB resistance in the field for many years. In this study, an F6:8 recombinant inbred line (RIL) population derived from cross Centrum × Xinong 979 was evaluated for FHB response following point inoculation in five environments. The population and parents were genotyped using the GenoBaits Wheat 16 K Panel. Stable quantitative trait loci (QTL) associated with FHB resistance in Centrum were mapped on chromosome arms 2DS and 5BS...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537136/effective-consistent-and-rapid-non-contact-application-methods-for-seedling-basal-stem-infection-by-sclerotinia-sclerotiorum
#5
JOURNAL ARTICLE
Viet-Cuong Han, Pippa J Michael, Rachael Crockett, Bec Swift, Sarita J Bennett
Sclerotinia sclerotiorum (Lib.) de Bary, an economically devastating soil-borne fungal pathogen known to cause disease across a wide range of plants, produces long-term inoculum called sclerotia that can either germinate carpogenically by ascospores infecting above-ground plant parts or myceliogenically to infect stem base and roots. Typically for research purposes S. sclerotiorum diseases are initiated by direct contact methods, using S. sclerotiorum mycelium agar plugs wrapped around the stem or sclerotia placed directly beneath root mass...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537130/comprehensive-molecular-classification-predicted-microenvironment-profiles-and-therapy-response-for-hepatocellular-carcinoma
#6
JOURNAL ARTICLE
Yihong Chen, Xiangying Deng, Yin Li, Ying Han, Yinghui Peng, Wantao Wu, Xinwen Wang, Jiayao Ma, Erya Hu, Xin Zhou, Edward Shen, Shan Zeng, Changjing Cai, Yiming Qin, Hong Shen
BACKGROUND AND AIMS: Tumor microenvironment (TME) heterogeneity leads to a discrepancy in survival prognosis and clinical treatment response for hepatocellular carcinoma (HCC) patients. The clinical applications of documented molecular subtypes are constrained by several issues. APPROACH AND RESULTS: We integrated three single-cell datasets to describe the TME landscape and identified six prognosis-related cell subclusters. Unsupervised clustering of subcluster-specific markers was performed to generate transcriptomic subtypes...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537125/efficacy-of-a-novel-antibiotic-drug-combination-toward-multidrug-resistant-ocular-pathogens
#7
JOURNAL ARTICLE
Lakshminarayanan Gowtham, Rachel A F Wozniak, Paul M Dunman, Esther Sheba, Prashant Garg, Joveeta Joseph
PURPOSE: Antimicrobial resistance is a global health threat, compounded by the reduction in the discovery of new antibiotics. A repurposed drugs-based approach could provide a viable alternative for the treatment of multidrug-resistant (MDR) bacterial infections. In this study, we sought to evaluate the in vitro efficacy of a novel drug combination, polymyxin B/trimethoprim (PT) + rifampin on MDR isolates from patients with bacterial keratitis in India. METHODS: Forty-three isolates, which included 20 Staphylococcus aureus, 19 Pseudomonas aeruginosa, 3 Pseudomonas stutzeri, and 1 Acinetobacter baumannii, were evaluated for their antibiotic resistance by minimum inhibitory concentration (MIC)...
March 26, 2024: Cornea
https://read.qxmd.com/read/38537104/biosynthesis-of-scopoletin-in-sweet-potato-confers-resistance-against-fusarium-oxysporum
#8
JOURNAL ARTICLE
Jing Wang, Peitao Chen, Tengfei Zhao, Xianhui Huang, Jikai Zong, Qingqing Luo, Chao Peng, Xiaoyan Wu, Fei Qiu, Dongchao Zhao, Lien Xiang, Yan Zhang, Chunxian Yang, Fangyuan Zhang, Zhihua Liao, Yufan Fu, Junlan Zeng
Fusarium wilt is a severe fungal disease caused by Fusarium oxysporum in sweet potato. We conducted transcriptome analysis to explore the resistance mechanism of sweet potato against F. oxysporum . Our findings highlighted the role of scopoletin, a hydroxycoumarin, in enhancing resistance. In vitro experiments confirmed that scopoletin and umbelliferone had inhibitory effects on the F. oxysporum growth. We identified hydroxycoumarin synthase genes IbF6'H2 and IbCOSY that are responsible for scopoletin production in sweet potatoes...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38537086/effect-of-dexmedetomidine-on-the-incidence-of-postoperative-acute-kidney-injury-in-living-donor-liver-transplantation-recipients-a-randomized-controlled-trial
#9
JOURNAL ARTICLE
Hye-Mee Kwon, Sa-Jin Kang, Sang-Bin Han, Jae Hwan Kim, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Acute kidney injury (AKI) is one of the most common complications after living-donor liver transplantation (LDLT) that has great impact on recipient and graft outcomes. Dexmedetomidine is reported to decrease the incidence of AKI. In the current study, we investigated whether intraoperative dexmedetomidine infusion would reduce the AKI following LDLT. MATERIAL AND METHODS: In total, 205 adult patients undergoing elective LDLT were randomly assigned to the dexmedetomidine group (n=103) or the control group (n=102)...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537027/home-vs-gym-based-exercise-delivery-modes-of-two-multicomponent-intensity-training-regimes-on-cardiorespiratory-fitness-and-arterial-stiffness-in-adults-with-intellectual-and-developmental-disability-during-the-covid-19-pandemic-a-randomized-controlled-trial
#10
JOURNAL ARTICLE
Xavier Melo, Bruno Simão, Catarina Catela, Isabel Oliveira, Sara Planche, Ana Louseiro, João Luís Marôco, Guillermo R Oviedo, Bo Fernhall, Helena Santa-Clara
Background: We compared the effects of home- vs gym-based delivery modes of two 8-week supervised multicomponent intensity training regimes on cardiorespiratory fitness and arterial stiffness in 17 adults with intellectual and developmental disability during the COVID-19 pandemic. Methods : Participants were assigned to sprint interval training or continuous aerobic training, both incorporating resistance training. The intervention started with 8-weeks of online training (M1-M2), 1-month of detraining, plus 8-weeks of gym-based training (M3-M4)...
March 27, 2024: Journal of Intellectual Disabilities: JOID
https://read.qxmd.com/read/38537024/evaluation-the-stress-distribution-in-root-canals-by-3d-finite-element-analysis-after-the-materials-used-in-reattaching-the-vertically-root-fractured-fragments
#11
JOURNAL ARTICLE
Senem Yiğit Özer, Salih Danişman, Törem Özer
The aim was to evaluate the effect of stress distribution on vertical, horizontal, and oblique forces on the tooth model after reattaching the fragments of the maxillary incisor with vertical root fracture (VRF) using different materials, by 3D finite element analysis (FEA). Tooth with a root canal, spongious, and cortical bone models were designed. VRF was modeled on a tooth with 4 different re-attachment models: Group 1: dual-cure cement (DC)+fiber reinforced composite (FRC), Group 2: DC+polyethylene fiber, Group 3: DC+glass fiber, and Group 4:DC...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38537021/impact-of-access-cavity-design-on-fracture-resistance-of-endodontically-treated-maxillary-first-premolar-in-vitro
#12
JOURNAL ARTICLE
Anju Daniel, Abdul Rahman Saleh, Anas Al-Jadaa, Waad Kheder
This study was designed to investigate the impact of access cavity designs on fracture resistance of endodontically treated maxillary first premolars. The study sample consisted of 72 intact maxillary first premolars, randomly divided into six groups (n = 12). A standardized proximal cavity preparation was prepared for all samples using standard bur. Groups I: control group with only standard proximal cavity and no endodontic access, group II: Truss access cavity, group III: Separated access to buccal and palatal canals without removal of dentine in between, group IV: Access to buccal and palatal canals with removal of dentine in between, group V: Traditional access cavity, group VI: Mesio-occlusal-distal cavity (MOD)...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38536968/manganese-nanoparticles-synthesis-mechanisms-of-influence-on-plant-resistance-to-stress-and-prospects-for-application-in-agricultural-chemistry
#13
REVIEW
Alla I Perfileva, Konstantin V Krutovsky
Manganese (Mn) is an important microelement for the mineral nutrition of plants, but it is not effectively absorbed from the soil and mineral salts added thereto and can also be toxic in high concentrations. Mn nanoparticles (NPs) are less toxic, more effective, and economical than Mn salts due to their nanosize. This article critically reviews the current publications on Mn NPs, focusing on their effects on plant health, growth, and stress tolerance, and explaining possible mechanisms of their effects. This review also provides basic information and examples of chemical, physical, and ecological ("green") methods for the synthesis of Mn NPs...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38536967/uncovering-the-power-of-hsccc-separation-of-diastereomeric-and-regioisomeric-styrylpyrones-from-the-stem-bark-of-goniothalamus-leiocarpus
#14
JOURNAL ARTICLE
Xiao Liu, Ling-Yun Li, Zhi-Qin Zhang, Xiu-Chuan Fu, Rong-Sheng Li, Jia-Li Yao, Simon Gibbons, Qing Mu
The plant Goniothalamus leiocarpus of the Annonaceae family is used as an alternative medicine in tropical regions. Applying high-speed counter current chromatography (HSCCC), eight new bioactive styrylpyrone isomers, including 6 R ,7 S ,8 R ,2' S -goniolactone B ( 1 ), 6 S ,7 S ,8 S ,2' S -goniolactone B ( 2 ), 6 R ,7 R ,8 R ,2' S -goniolactone B ( 3 ), 6 R ,7 S ,8 S ,2' S -goniolactone C ( 4 ), 6 R ,7 S ,8 R ,2' S -goniolactone C ( 5 ), 6 S ,7 R ,8 S ,2' S -goniolactone C ( 6 ), and two positional isomers, 6 R ,7 R ,8 R ,2' S -goniolactone G ( 7 ) and 6 S ,7 R ,8 R ,2' S -goniolactone G ( 8 ), were isolated from a chloroform fraction (2...
March 27, 2024: Journal of Natural Products
https://read.qxmd.com/read/38536950/trends-in-the-potential-of-stilbenes-to-improve-plant-stress-tolerance-insights-of-plant-defense-mechanisms-in-response-to-biotic-and-abiotic-stressors
#15
REVIEW
Qingchao Gao, Renyu Zheng, Jun Lu, Xue Li, Di Wang, Xinyu Cai, Xueyan Ren, Qingjun Kong
Stilbenes belong to the naturally synthesized plant phytoalexins, produced de novo in response to various biotic and abiotic stressors. The importance of stilbenes in plant resistance to stress and disease is of increasing interest. However, the defense mechanisms and potential of stilbenes to improve plant stress tolerance have not been thoroughly reviewed. This work overviewed the pentose phosphate pathway, glycolysis pathway, shikimate pathway, and phenylalanine pathway occurred in the synthesis of stilbenes when plants are subjected to biotic and abiotic stresses...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38536948/control-etched-ti-3-c-2-t-x-mxene-nanosheets-for-a-low-voltage-operating-flexible-memristor-for-efficient-neuromorphic-computation
#16
JOURNAL ARTICLE
Jeny Gosai, Mansi Patel, Lingli Liu, Aziz Lokhandwala, Parth Thakkar, Mun Yin Chee, Muskan Jain, Wen Siang Lew, Nitin Chaudhari, Ankur Solanki
Hardware neural networks with mechanical flexibility are promising next-generation computing systems for smart wearable electronics. Overcoming the challenge of developing a fully synaptic plastic network, we demonstrate a low-operating-voltage PET/ITO/p-MXene/Ag flexible memristor device by controlling the etching of aluminum metal ions in Ti3 C2 T x MXene. The presence of a small fraction of Al ions in partially etched MXene (p-Ti3 C2 T x ) significantly suppresses the operating voltage to 1 V compared to 7 V from fully Al etched MXene (f-Ti3 C2 T x )-based devices...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38536947/layer-number-dependent-magnetism-in-the-co-doped-van-der-waals-ferromagnet-fe-3-gate-2
#17
JOURNAL ARTICLE
Mingjie Wang, Kejia Zhu, Bin Lei, Yazhou Deng, Tao Hu, Dongsheng Song, Haifeng Du, Mingliang Tian, Ziji Xiang, Tao Wu, Xianhui Chen
Recently, van der Waals (vdW) antiferromagnets have been proposed to be crucial for spintronics due to their favorable properties compared to ferromagnets, including robustness against magnetic perturbation and high frequencies of spin dynamics. High-performance and energy-efficient spin functionalities often depend on the current-driven manipulation and detection of spin states, highlighting the significance of two-dimensional metallic antiferromagnets, which have not been much explored due to the lack of suitable materials...
March 27, 2024: Nano Letters
https://read.qxmd.com/read/38536921/glutamine-antagonist-drp-104-suppresses-tumor-growth-and-enhances-response-to-checkpoint-blockade-in-keap1-mutant-lung-cancer
#18
JOURNAL ARTICLE
Ray Pillai, Sarah E LeBoeuf, Yuan Hao, Connie New, Jenna L E Blum, Ali Rashidfarrokhi, Shih Ming Huang, Christian Bahamon, Warren L Wu, Burcu Karadal-Ferrena, Alberto Herrera, Ellie Ivanova, Michael Cross, Jozef P Bossowski, Hongyu Ding, Makiko Hayashi, Sahith Rajalingam, Triantafyllia Karakousi, Volkan I Sayin, Kamal M Khanna, Kwok-Kin Wong, Robert Wild, Aristotelis Tsirigos, John T Poirier, Charles M Rudin, Shawn M Davidson, Sergei B Koralov, Thales Papagiannakopoulos
Loss-of-function mutations in KEAP1 frequently occur in lung cancer and are associated with poor prognosis and resistance to standard of care treatment, highlighting the need for the development of targeted therapies. We previously showed that KEAP1 mutant tumors consume glutamine to support the metabolic rewiring associated with NRF2-dependent antioxidant production. Here, using preclinical patient-derived xenograft models and antigenic orthotopic lung cancer models, we show that the glutamine antagonist prodrug DRP-104 impairs the growth of KEAP1 mutant tumors...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536889/multilocus-sequence-typing-and-antibiotic-resistance-of-aeromonas-isolated-from-freshwater-fish-in-hebei-province
#19
JOURNAL ARTICLE
Zixiao Yu, Yunseok Oh, Songmi Kim, Kyudong Han, Kornsorn Srikulnath, Qingyang Li, Ji-Seok Jang, Ho-Seong Lee
Aeromonas spp. are the opportunistic pathogens that infect both aquatic and terrestrial homeotherms. They were commonly present in aquatic environments, including effluent, tap water, marine, river, and lake, where they are often isolated from aquatic animals, including fish, molluscs, and crustaceans. The Aeromonas infections can cause sepsis, ulcer, and other symptoms, resulting in the death of massive aquatic animals. Therefore, the prevention and control of Aeromonas is of great significance for the healthy development of aquaculture...
2024: PloS One
https://read.qxmd.com/read/38536862/ultrastable-iodinated-oil-based-pickering-emulsion-enables-locoregional-sustained-codelivery-of-hypoxia-inducible-factor-1-inhibitor-and-anticancer-drugs-for-tumor-combination-chemotherapy
#20
JOURNAL ARTICLE
Zhihua Li, Xiaoya Liu, Jingyu Xiao, Hang Jiang, Le Ma, Yucheng Luo, Meijuan Wang, Yuwei Zhu, Hongliang Jiang, Hanyang Yao, To Ngai, Qiongyu Guo
Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i...
March 27, 2024: ACS Biomaterials Science & Engineering
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