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https://www.readbyqxmd.com/read/29031237/novel-methodology-for-determining-the-effect-of-adsorbates-on-human-enamel-acid-dissolution
#1
N Pechlivani, D A Devine, P D Marsh, A Mighell, S J Brookes
OBJECTIVE: The effect of various interventions on enamel demineralisation can be determined by chemically measuring mineral ions dissolved by the attacking acid. Results are usually expressed as mineral loss per surface area of enamel exposed. Acid resistant varnish or adhesive tape are typically used to delineate an area of enamel. However, enamel surface curvature, rugosity and porosity reduce the reliability of simple area measurements made at the macro scale. Our aim was to develop a simple method for investigating the effect of adsorbates on enamel demineralisation that does not rely on knowing the area of enamel exposed...
October 3, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29031224/direct-one-pot-synthesis-of-cinnamaldehyde-immobilized-on-gold-nanoparticles-and-their-antibiofilm-properties
#2
Mohankandhasamy Ramasamy, Jin-Hyung Lee, Jintae Lee
The objective of the present study was to develop a one-pot strategy to synthesis gold nanoparticle complexes using cinnamaldehyde, a potent antibiofilm agent which in its free form, exhibits high volatility and unstable nature. Hence, we developed cinnamaldehyde gold nanoparticles (CGNPs) in a single step to overcome the limitations of free cinnamaldehyde. Furthermore, reduction abilities of cinnamaldehyde under different experimental conditions, that is, varying precursor concentrations of cinnamaldehyde and gold, metal salts, pH, temperature, and light sources, were investigated...
October 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29031213/impairment-of-heart-rhythm-complexity-in-patients-with-drug-resistant-epilepsy-an-assessment-with-multiscale-entropy-analysis
#3
Hongyun Liu, Zhao Yang, Fangang Meng, Yuguang Guan, Yanshan Ma, Shuli Liang, Jiuluan Lin, Longsheng Pan, Mingming Zhao, Wei Qu, Hongwei Hao, Guoming Luan, Jianguo Zhang, Luming Li
OBJECTIVE: Epilepsy and seizures can have dramatic effects on the cardiac function. The aim of this study was to investigate the heart rhythm complexity in patients with drug-resistant epilepsy (DRE). METHODS: Ambulatory 24-h electrocardiograms (ECG) from 70 DRE patients and 50 healthy control subjects were analyzed using conventional heart rate variability (HRV) and multiscale entropy (MSE) methods The variation of complexity indices (CI), which was calculated from MSE profile, was determined...
October 5, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29031210/effect-of-photoactivated-riboflavin-on-the-biodegradation-resistance-of-root-dentin-collagen
#4
Balasankar Meera Priyadarshini, Thong Beng Lu, Amr S Fawzy
This study was conducted to evaluate the effect of UVA-activated 1% riboflavin solution on structural integrity; mechanical properties and stability; and collagenase-mediated collagen solubilisation resistance of demineralized root dentin collagen matrix. Root dentin specimens demineralized with 17% EDTA for 7days were treated with 1% RF for 1min followed by UVA photo-activation at intensity 7mW/cm(2) for 1min. Control specimens were completely devoid of riboflavin and/or UVA treatments. Specimens were challenged with bacterial collagenase type-I solution for different time-periods at 37°C...
October 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29031202/targeting-of-cell-cycle-and-let-7a-stat3-pathway-by-niclosamide-inhibits-proliferation-migration-and-invasion-in-oral-squamous-cell-carcinoma-cells
#5
Xiaoxu Li, Ruiyu Ding, Zewen Han, Zeyun Ma, Yixiang Wang
The low median survival rate of oral squamous cell carcinoma (OSCC) is associated with chemotherapeutic resistance. Niclosamide is an oral anti-helminthic drug, its anti-cancer effect has been reported in recent years. However, the effect of niclosamide on OSCC remains largely unknown. In this study, we, for the first time, investigated the underlying mechanisms from cell cycle arrest and let-7a/STAT3 axis through CCK-8, cell cycle, apoptosis, wound healing, Transwell invasion, generation of stable cell line, real-time PCR, and western blot assays using two OSCC cell lines WSU-HN6 and Tca83...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031200/oleanolic-acid-methyl-ester-a-novel-cytotoxic-mitocan-induces-cell-cycle-arrest-and-ros-mediated-cell-death-in-castration-resistant-prostate-cancer-pc-3-cells
#6
Noha Abdelmageed, Samy A F Morad, Ashraf A Elghoneimy, Tatiana Syrovets, Thomas Simmet, Hesham El-Zorba, Hossney A El-Banna, Myles Cabot, Magdy I Abdel-Aziz
Oleanolic acid derivatives exhibit potent anticancer activities against numerous types of cancer. However, the antitumor activity of oleanolic acid methylester (OAME), an oleanolic acid derivative, against prostate cancer has not been studied. Hence, the present work was conducted to study the anticancer activities of OAME. Viability assay showed that treatment of cancer cells with OAME induced a significant cell death in concentration- and time-dependent manner. Of note, OAME displayed a selective cytotoxicity against cancer cells compared to normal epithelial cells...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031198/tretinoin-loaded-lipid-core-nanocapsules-overcome-the-triple-negative-breast-cancer-cell-resistance-to-tretinoin-and-show-synergistic-effect-on-cytotoxicity-induced-by-doxorubicin-and-5-fluororacil
#7
Eduarda Schultze, Julieti Buss, Karine Coradini, Karine Rech Begnini, Silvia S Guterres, Tiago Collares, Ruy Carlos Ruver Beck, Adriana R Pohlmann, Fabiana Kömmling Seixas
Nanostructured drug delivery systems have been extensively studied, mainly for applications in cancer therapy. The advantages of these materials include protection against drug degradation and improvement in both the relative solubility of poorly water soluble drugs as in targeting of therapy, due to the enhanced permeability and retention effect on tumor sites. In this work, we evaluate the antitumor activity of tretinoin-loaded lipid core nanocapsules (TT-LNC) in a tretinoin-resistant breast cancer cell-line, MDA-MB- 231, as well as the synergistic effect of combination of this treatment with 5-FU or DOXO...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031197/mitochondrial-dysfunction-is-responsible-for-fatty-acid-synthase-inhibition-induced-apoptosis-in-breast-cancer-cells-by-pdpamn
#8
Qiang Wang, Xia Du, Bingjie Zhou, Jing Li, Wenlong Lu, Qiuyun Chen, Jing Gao
Targeting cellular metabolism is becoming a hallmark to overcome drug resistance in breast cancer treatment. Activation of fatty acid synthase (FASN) has been shown to promote breast cancer cell growth. However, there is no concrete report underlying the mechanism associated with mitochondrial dysfunction in relation to fatty acid synthase inhibition-induced apoptosis in breast cancer cells. The current study is aimed at exploring the effect of the novel manganese (Mn) complex, labeled as PdpaMn, on lipid metabolism and mitochondrial function in breast cancer cells...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031195/ginsenoside-rg3-attenuates-cisplatin-resistance-in-lung-cancer-by-downregulating-pd-l1-and-resuming-immune
#9
Zhansheng Jiang, Yanfang Yang, Yinli Yang, Yu Zhang, Zhensong Yue, Zhanyu Pan, Xiubao Ren
Programmed death ligand 1 (PD-L1) as one the most important immune checkpoint was verified to involve in chemotherapy resistance in non-small cell lung cancer (NSCLC). Ginsenoside Rg3 is isolated from Chinese herb-Panax ginseng which is recognized to boost immune and has anti-cancer activity against a majority of carcinomas including NSCLC. In this study, we aim to identify whether Rg3 could attenuate the PD-L1 expression induced by resistance to cisplatin and draw out the underlying mechanisms of PD-L1 in this process...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031193/the-retention-of-lacosamide-in-patients-with-epilepsy-and-intellectual-disability-in-three-specialised-institutions
#10
J Brenner, H J M Majoie, S van Beek, J A Carpay
PURPOSE: We describe the effectiveness of lacosamide as adjunctive therapy in patients with epilepsy and an intellectual disability. This information is relevant, as few data exist pertaining to this population with a high prevalence of (intractable) epilepsy. METHODS: We performed a retrospective study in three specialised institutions. Inclusion criteria were (1) focal onset or symptomatic generalized (2) therapy-resistant epilepsy, (3) intellectual disability and (4) residence in a care-facility for people with intellectual disabilities (PWID)...
October 3, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29031157/a-european-multi-centre-external-quality-assessment-eqa-study-on-phenotypic-and-genotypic-methods-used-for-herpes-simplex-virus-hsv-drug-resistance-testing
#11
Baharak Afshar, David F Bibby, Renata Piorkowska, Natasha Ohemeng-Kumi, Robert Snoeck, Graciela Andrei, Sarah Gillemot, Florence Morfin, Emilie Frobert, Sonia Burrel, David Boutolleau, Brendan Crowley, Jean L Mbisa
BACKGROUND: Herpes Simplex Virus (HSV) drug resistance is a significant public health concern among immunocompromised individuals. Phenotypic assays are considered the gold standard method for detecting HSV drug resistance. However, plaque reduction assays (PRAs) are technically demanding, often with long turnaround times of up to four weeks. In contrast, genotypic tests can be performed within a few days. OBJECTIVES: The development and coordination of the first European External Quality Assessment (EQA) study to evaluate phenotypic and genotypic methods used for HSV drug resistance testing in specialised reference laboratories...
October 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29031106/new-insights-into-resistance-to-colistin-and-third-generation-cephalosporins-of-escherichia-coli-in-poultry-portugal-novel-blactx-m-166-and-blaesac-genes
#12
Vera Manageiro, Lurdes Clemente, Rafael Graça, Ivone Correia, Teresa Albuquerque, Eugénia Ferreira, Manuela Caniça
The increasing incidence of intestinal colonization with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and Gram negative organisms that has been observed in food animals such as poultry, cattle and pigs, are suggestive that animals, food and environment are potential sources of ESBL-producing bacteria. Hence, the aim of this study was to characterized commensal E. coli obtained from healthy broiler and turkey flocks at slaughter for the presence of penicillinases-, ESBL-, extended-spectrum AmpC (ESAC)-, plasmid-mediated quinolone resistance- and MCR-encoding genes...
October 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29031077/4-quinolone-hybrids-and-their-antibacterial-activities
#13
Yuan-Qiang Hu, Shu Zhang, Zhi Xu, Zao-Sheng Lv, Ming-Liang Liu, Lian-Shun Feng
The emergence and wide-spread of drug-resistant bacteria including multi-drug resistant and pan-drug resistant pathogens which are associated with considerable mortality, represent a significant global health threat. 4-Quinolones which are exemplified by fluoroquinolones are the second largest chemotherapy agents used in clinical practice for the treatment of various bacterial infections. However, the resistance of bacteria to 4-quinolones develops rapidly and spreads widely throughout the world due to the long-term, inappropriate use and even abuse...
September 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031068/platinum-iv-prodrugs-multiply-targeting-genomic-dna-histone-deacetylases-and-parp-1
#14
Zichen Xu, Weiwei Hu, Zhimei Wang, Shaohua Gou
Several Pt(IV) prodrugs containing SAA, a histone deacetylases inhibitor, were designed and prepared for multiply targeting genomic DNA, histone deacetylases and PARP-1. The resulting Pt(IV) prodrug had significantly strong antiproliferative activity against the tested cancer cell lines, especially SAA1, derived from the conjugation of cisplatin and SAA, had potent ability to overcome cisplatin resistance. Under the combined action of DNA platination and inhibition of HDACs and PARP-1 activity, the cytotoxic activity of SAA1 was 174-fold higher than cisplatin against cisplatin-resistant SGC7901/CDDP cancer cells...
October 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29029346/botanical-compound-p-anisaldehyde-repels-larval-lone-star-tick-acari-ixodidae-and-halts-reproduction-by-gravid-adults
#15
Allan T Showler, Jessica L Harlien
The lone star tick, Amblyomma americanum (L.), widely distributed across eastern, southeastern, and midwestern regions of the United States and south into Mexico, is an obligate blood feeder that attaches to three hosts during the larval, nymphal, and adult stages. White-tailed deer and wild turkey are common hosts, as well as a wide variety of other avian and mammalian hosts. Amblyomma americanum is the most frequently reported species of tick to bite humans in the southeastern and southcentral United States, and it can transmit diseases that include erhlichiosis, rickettsiosis, tularemia, and protozoan infections...
October 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029317/the-critical-role-of-supply-chains-in-preventing-human-immunodeficiency-virus-drug-resistance-in-low-and-middle-income-settings
#16
Thomas Minior, Meaghan Douglas, Dianna Edgil, Meena Srivastava, John Crowley, Jacqueline Firth, Ilana Lapidos-Salaiz, Jason Williams, Lana Lee
The functioning of the supply chain may be a driving factor behind the development of human immunodeficiency virus (HIV) drug resistance (HIVDR) in many low- and middle-income countries (LMICs). Additionally, the effectiveness of supply chains will likely impact the scale-up of both viral-load monitoring and HIVDR testing. This article describes the complexities of global supply chains relevant for LMICs and presents early data on stock-outs and drug substitutions in several countries supported by the US President's Emergency Plan for AIDS Relief...
October 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029285/selection-of-reference-genes-for-expression-studies-in-diaphorina-citri-hemiptera-liviidae
#17
Meire Menezes Bassan, Je Ssika Angelotti-Mendonc A, Gustavo Rodrigues Alves, Pedro Takao Yamamoto, Francisco de Assis Alves Moura O Filho
The Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae), is considered the main vector of the bacteria associated with huanglongbing, a very serious disease that has threatened the world citrus industry. The absence of efficient control management protocols, including a lack of resistant cultivars, has led to the development of different approaches to study this pathosystem. The production of resistant genotypes relies on D. citri gene expression analyses by RT-qPCR to assess control of the vector population...
September 27, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29029259/first-experimental-assessment-of-protein-intrinsic-disorder-involvement-in-an-rna-virus-natural-adaptive-process
#18
Justine Charon, Amandine Barra, Jocelyne Walter, Pauline Millot, Eugénie Hébrard, Benoît Moury, Thierry Michon
Intrinsic disorder (ID) in proteins is defined as a lack of stable structure in physiological conditions. Intrinsically disordered regions (IDRs) are highly abundant in some RNA virus proteomes. Low topological constraints exerted on IDRs are expected to buffer the effect of numerous deleterious mutations and could be related to the remarkable adaptive potential of RNA viruses to overcome resistance of their host. To experimentally test this hypothesis in a natural pathosystem, a set of four variants of Potato virus Y (PVY; Potyvirus genus) containing various ID degrees in the Viral genome-linked (VPg) protein, a key determinant of potyvirus adaptation, was designed...
September 18, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29029256/multicentre-validation-of-4-well-azole-agar-plates-as-a-screening-method-for-detection-of-clinically-relevant-azole-resistant-aspergillus-fumigatus
#19
Maiken Cavling Arendrup, Paul E Verweij, Johan W Mouton, Katrien Lagrou, Joseph Meletiadis
Objectives: Azole-resistant Aspergillus fumigatus is emerging worldwide. Reference susceptibility testing methods are technically demanding and no validated commercial susceptibility tests for moulds currently exist. In this multicentre study a 4-well azole-containing screening agar method was evaluated using clinically relevant isolates. Methods: Forty WT and 39 cyp51A mutant A. fumigatus [G54 (n = 10), M220 (n = 10), TR34/L98H (n = 9) and TR46/Y121F/T289A (n = 10)] were tested individually and as simulated mixed samples (sampling 4 WT and 1 mutant colonies)...
October 4, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29029255/plasmids-can-transfer-to-clostridium-difficile-cd37-and-630%C3%AE-erm-both-by-a-dnase-resistant-conjugation-like-mechanism-and-a-dnase-sensitive-mechanism
#20
Ladan Khodadoost, Haitham Hussain, Peter Mullany
Broad host range conjugative plasmids that replicate in Escherichia coli have been widely used to mobilise smaller replicons, bearing their cognate origin of transfer (oriT) into a variety of organisms that are less tractable genetically, such as Clostridium (Clostridioides) difficile. In this work we demonstrated that the oriT region of pMTL9301 (derived from RK2) is not required for transfer between E. coli and C. difficile strains 630Δerm and CD37 and that this oriT-independent transfer is abolished in the presence of DNase when CD37 is the recipient...
October 4, 2017: FEMS Microbiology Letters
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