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https://www.readbyqxmd.com/read/29223098/trisubstituted-barbiturates-and-thiobarbiturates-synthesis-and-biological-evaluation-as-xanthine-oxidase-inhibitors-antioxidants-antibacterial-and-anti-proliferative-agents
#1
Joana Figueiredo, João L Serrano, Eunice Cavalheiro, Leena Keurulainen, Jari Yli-Kauhaluoma, Vânia M Moreira, Susana Ferreira, Fernanda C Domingues, Samuel Silvestre, Paulo Almeida
Barbituric and thiobarbituric acid derivatives have become progressively attractive to medicinal chemists due to their wide range of biological activities. Herein, different series of 1,3,5-trisubstituted barbiturates and thiobarbiturates were prepared in moderate to excellent yields and their activity as xanthine oxidase inhibitors, antioxidants, antibacterial agents and as anti-proliferative compounds was evaluated in vitro. Interesting bioactive barbiturates were found namely, 1,3-dimethyl-5-[1-(2-phenylhydrazinyl)ethylidene]pyrimidine-2,4,6(1H,3H,5H)-trione (6c) and 1,3-dimethyl-5-[1-[2-(4-nitrophenyl)hydrazinyl]ethylidene]pyrimidine-2,4,6(1H,3H,5H)-trione (6e), which showed concomitant xanthine oxidase inhibitory effect (IC50 values of 24...
November 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29223067/dissection-of-resistance-to-microdochium-nivale-in-lolium-multiflorum-festuca-arundinacea-introgression-forms
#2
Agnieszka Płażek, Ewa Pociecha, Adam Augustyniak, Katarzyna Masajada, Michał Dziurka, Joanna Majka, Dawid Perlikowski, Izabela Pawłowicz, Arkadiusz Kosmala
The potential of resistance to Microdochium nivale is still not recognized for numerous plant species. The forage grasses of Lolium-Festuca complex are important for grass-biomass production in the temperate regions. Lolium multiflorum is a grass with a high forage quality and productivity but also a relatively low resistance to M. nivale. On the contrary, F. arundinacea has a higher potential of resistance but simultaneously a significantly lower forage quality. These two species cross with each other and the intergeneric hybrids possess complementary characters of both genera...
December 5, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29223035/use-of-hop-extract-as-antifungal-ingredient-for-bread-making-and-selection-of-autochthonous-resistant-starters-for-sourdough-fermentation
#3
Luana Nionelli, Erica Pontonio, Marco Gobbetti, Carlo Giuseppe Rizzello
No abstract text is available yet for this article.
December 5, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29223024/genomic-integration-and-expression-of-the-aggregatibacter-actinomycetemcomitans-catalase-gene-in-aggregatibacter-aphrophilus
#4
Yuting Alice Yang, Ya-An Cheng, Casey Chen
OBJECTIVE: To test the hypothesis that virulence genes of Aggregatibacter actinomycetemcomitans can be expressed and confer fitness advantages in the closely related Aggregatibacter aphrophilus. DESIGN: Clinical isolates of A. aphrophilus were screened for natural competence with marked genomic DNA from A. actinomycetemcomitans and A. aphrophilus. The gene katA of A. actinomycetemcomitans D7S-1 and its flanking regions were constructed and inserted into a comparable locus in the genome of a naturally competent A...
December 5, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29223022/next-generation-industrial-biotechnology-based-on-extremophilic-bacteria
#5
REVIEW
Guo-Qiang Chen, Xiao-Ran Jiang
Industrial biotechnology aims to produce bulk chemicals including polymeric materials and biofuels based on bioprocessing sustainable agriculture products such as starch, fatty acids and/or cellulose. However, traditional bioprocesses require bioreactors made of stainless steel, complicated sterilization, difficult and expensive separation procedures as well as well-trained engineers that are able to conduct bioprocessing under sterile conditions, reducing the competitiveness of the bio-products. Amid the continuous low petroleum price, next generation industrial biotechnology (NGIB) allows bioprocessing to be conducted under unsterile (open) conditions using ceramic, cement or plastic bioreactors in a continuous way, it should be an energy, water and substrate saving technology with convenient operation procedure...
December 6, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29223009/influence-of-spermatozoal-lipidomic-profile-on-the-cryoresistance-of-frozen-spermatozoa-from-stallions
#6
T Cabrera, C Ramires-Neto, K R A Belaz, C P Freitas-Dell'aqua, D Zampieri, A Tata, M N Eberlin, M A Alvarenga, F F Souza
The membrane of spermatozoa, which contributes to cellular cryoresistance, contains numerous lipids with a composition that directly affects membrane fluidity and the fertilization process. In light of variations in the degree of sensitivity in equine seminal freezing, this study aimed to correlate equine semen lipids with post-thawing characteristics of spermatozoa. We used ejaculates from 34 stallions, which were evaluated (total motility ≥ 60%), frozen and thawed and reevaluated for motility of spermatozoa, membrane integrity and lipid peroxidation...
November 26, 2017: Theriogenology
https://www.readbyqxmd.com/read/29222975/hydrothermal-synthesis-of-hierarchical-coo-sno2-nanostructures-for-ethanol-gas-sensor
#7
Qingji Wang, Xueying Kou, Chang Liu, Lianjing Zhao, Tingting Lin, Fangmeng Liu, Xueli Yang, Jun Lin, Geyu Lu
In this work, ethanol gas sensor with high performance was fabricated successfully with hierarchical CoO/SnO2 heterojunction by two-steps hydrothermal method. The response value of CoO/SnO2 sensor is up to 145 at 250 °C when exposed to 100 ppm ethanol gas, which is much higher than that (13.5) of SnO2 sensor. These good sensing performances mainly attribute to the formation of the CoO/SnO2 heterojunction, which makes great variation of resistance in air and ethanol gas. Thus, the combination of n-type SnO2 and p-type CoO provides an effective strategy to design new ethanol gas sensors...
December 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29222969/copper-ii-complexes-of-n3o-tripodal-ligands-appended-with-pyrene-and-polyamine-groups-anti-proliferative-and-nuclease-activities
#8
Doti Serre, Sule Erbek, Nathalie Berthet, Xavier Ronot, Véronique Martel-Frachet, Fabrice Thomas
A series of tripodal ligands based on the 2-tert-butyl-4-R-6-phenol was synthesized, where R=aldehyde (HL1), R=putrescine-pyrene (HL2) and R=putrescine (HL3). A dinucleating ligand wherein a putrescine group connects two tripodal moieties was also prepared (H2L4). The corresponding copper complexes (1, 2, 3, and 4, respectively) were prepared and characterized. We determined the phenol's pKas in the range 2.47-3.93. The DNA binding constants were determined at 6×106, 5.5×105 and 2.7×106 for 2, 3 and 4, respectively...
November 11, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29222967/stimulation-of-the-endogenous-incretin-glucose-dependent-insulinotropic-peptide-by-enteral-dextrose-improves-glucose-homeostasis-and-inflammation-in-murine-endotoxemia
#9
Faraaz Ali Shah, Srikanth Singamsetty, Lanping Guo, Byron W Chuan, Sherie McDonald, Bryce A Cooper, Brett J O'Donnell, Darko Stefanovski, Burton Wice, Yingze Zhang, Christopher P O'Donnell, Bryan J McVerry
Loss of glucose homeostasis during sepsis is associated with increased organ dysfunction and higher mortality. Novel therapeutic strategies to promote euglycemia in sepsis are needed. We have previously shown that early low-level intravenous (IV) dextrose suppresses pancreatic insulin secretion and induces insulin resistance in septic mice, resulting in profound hyperglycemia and worsened systemic inflammation. In this study, we hypothesized that administration of low-level dextrose via the enteral route would stimulate intestinal incretin hormone production, potentiate insulin secretion in a glucose-dependent manner, and thereby improve glycemic control in the acute phase of sepsis...
November 21, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29222957/association-between-%C3%AE-cell-function-estimated-by-homa-%C3%AE-and-prognosis-of-nondiabetic-patients-with-ischaemic-stroke
#10
Mengyuan Zhou, Yuesong Pan, Jing Jing, Yongjun Wang, Xingquan Zhao, Liping Liu, Hao Li, Yilong Wang
BACKGROUND AND PURPOSE: Studies showed β-cell dysfunction was associated with increased risk of cardiovascular disease and subclinical carotid atherosclerosis. This study aimed to investigate the association between β-cell function and prognosis of nondiabetic patients with ischaemic stroke. METHODS: Ischaemic stroke patients without diabetes in the Abnormal Glucose Regulation in Patients with Acute Stroke across China registry were included in this analysis. Homeostasis assessment of β-cell function (HOMA-β), was performed and classified it into four groups according to quartiles...
December 9, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29222931/the-challenge-of-herbicide-resistance-around-the-world-a-current-summary
#11
REVIEW
Mark A Peterson, Alberto Collavo, Ramiro Ovejero, Vinod Shivrain, Michael J Walsh
Herbicide resistant weeds have been observed since the early years of synthetic herbicide development in the 1950's and 1960's. Since that time there has been a consistent increase in the number of herbicide resistance cases and the impact of herbicide resistant (HR) weeds. While the nature of crop production varies widely around the world, herbicides have become a primary tool for weed control in most areas. Dependence on herbicides continues to increase as global populations migrate away from rural areas into cities and the agricultural labor force declines...
December 9, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29222921/optimizing-rna-seq-studies-to-investigate-herbicide-resistance
#12
REVIEW
Darci A Giacomini, Todd Gaines, Roland Beffa, Patrick J Tranel
Transcriptomic profiling, specifically via RNA-seq, is becoming one of the more commonly used methods for investigating non-target site resistance (NTSR) to herbicides due to its high throughput capabilities and utility in organisms with little to no previous sequence information. A review of the weed science RNA-seq literature has revealed some basic principles behind generating quality data from these types of studies. First, studies that included more replicates per biotype and took steps to control for genetic background had significantly better control of false positives and, consequently, shorter lists of potential resistance genes to sift through...
December 9, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29222891/effects-of-preoperative-oral-carbohydrate-therapy-on-perioperative-glucose-metabolism-during-oral-maxillofacial-surgery-randomised-clinical-trial
#13
Kanako Esaki, Masanori Tsukamoto, Eiji Sakamoto, Takeshi Yokoyama
BACKGROUND AND OBJECTIVES: Preoperative oral carbohydrate therapy has been suggested to attenuate postoperative insulin resistance. The purpose of this study was to investigate the effect of a carbohydrate-rich beverage given preoperatively on intraoperative glucose metabolism. METHODS AND STUDY DESIGN: This study was a randomised, open-label, placebo-controlled trial. Patients undergoing oral-maxillofacial surgery were divided into two groups. In the glucose group, patients took glucose (50 g/278 mL, p...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222858/obesity-lipid-profiles-and-oxidative-stress-in-children-after-liver-transplantation
#14
Piotr Czubkowski, Aldona Wierzbicka, Joanna Pawłowska, Irena Jankowska, Piotr Socha
PURPOSE: In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after pediatric liver transplantation (LTx)...
December 10, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29222766/electrical-velocimetry-for-non-invasive-monitoring-of-the-closure-of-the-ductus-arteriosus-in-preterm-infants
#15
Ana Rodríguez Sánchez de la Blanca, M Sánchez Luna, N González Pacheco, M Arriaga Redondo, N Navarro Patiño
Closure of a patent ductus arteriosus (PDA) in preterm infants modifies cardiac output and induces adaptive changes in the hemodynamic situation. The present study aims to analyze those changes, through a non-invasive cardiac output monitor based on blood electrical velocimetry, in preterm babies. A prospective observational study of preterm infants with a gestational age of less than 28 weeks, and a hemodynamic significant PDA, requires intravenous ibuprofen or surgical closure. All patients were monitored with electrical velocimetry before treatment and through the following 72 h...
December 8, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29222698/efficacy-evaluation-of-iclaprim-in-a-neutropenic-rat-lung-infection-model-with-methicillin-resistant-staphylococcus-aureus-entrapped-in-alginate-microspheres
#16
David B Huang, Ian Morrissey, Timothy Murphy, Stephen Hawser, Mark H Wilcox
The objective of this study was to demonstrate the efficacy of iclaprim in a neutropenic rat lung infection model with methicillin-resistant Staphylococcus aureus (MRSA) entrapped in alginate beads. An inoculum of 5.25 × 105 colony-forming units (CFU)/mL of S. aureus strain AH1252 was administered intratracheally to rats with prepared alginate bacteria suspensions. Beginning 2 h post-infection, rats received: (1) iclaprim 80 mg/kg (n = 16); (2) iclaprim 60 mg/kg (n = 16), or (3) vancomycin 50 mg/kg (n = 24), for 3 days via subcutaneous (SC) injection every 12 h...
December 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29222694/preparation-and-evaluation-of-decellularized-porcine-carotid-arteries-cross-linked-by-genipin-the-preliminary-results
#17
Yongquan Gu, Fei Wang, Rong Wang, Jianxin Li, Cong Wang, Liqiang Li, Zeqin Xu, Jian Zhang
Decellularized arteries have been considered as promising scaffolds for small-diameter vascular substitutes. However, weakened mechanical properties, immunological rejection and rapid degradation after transplantation still exist after decellularization. Previous studies indicated that genipin cross-linking can solve these problems. Therefore, genipin was selected as the cross-linking agent for the pre-treatment of decellularized arteries in our study. Histological analysis, scanning electron microscopy, mechanical properties analysis and subcutaneous embedding experiment were adopted to investigate the efficiency of decellularization and the effect of genipin cross-linking on improving mechanical, structural and biological properties of decellularized arteries...
December 8, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29222693/neuroblastoma-pathogenesis-deregulation-of-embryonic-neural-crest-development
#18
REVIEW
Julie A Tomolonis, Saurabh Agarwal, Jason M Shohet
Neuroblastoma (NB) is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system. NB is highly heterogeneous both from a clinical and a molecular perspective. Clinically, this cancer represents a wide range of phenotypes ranging from spontaneous regression of 4S disease to unremitting treatment-refractory progression and death of high-risk metastatic disease. At a cellular level, the heterogeneous behavior of NB likely arises from an arrest and deregulation of normal neural crest development...
December 8, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29222656/changes-to-tetracyclines-and-tetracycline-resistance-genes-in-arable-soils-after-single-and-multiple-applications-of-manure-containing-tetracyclines
#19
Huicong Yan, Kun Zhang, Jiali Shentu, Dongsheng Shen, Na Li, Meizhen Wang
The influence of manure containing tetracyclines (TCs) on the prevalence of antibiotic resistance genes in soils remains poorly understood. Here, three different TCs (oxytetracycline (OTC), tetracycline (TC), and chlortetracycline (CTC)) were mixed respectively with unpolluted manure to fertilize arable soil. The soil received either a single application of 0 μg kg-1, 300 μg kg-1 (TC and CTC), or 700 μg kg-1 (OTC) or multiple applications every 14 days for 140 days. Four tetracycline resistance genes (TRGs), including tet(A), tet(L), tet(M), and tet(Q), were monitored...
December 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29222636/identification-introgression-and-molecular-marker-genetic-analysis-and-selection-of-a-highly-effective-novel-oat-crown-rust-resistance-from-diploid-oat-avena-strigosa
#20
Howard W Rines, Marisa E Miller, Martin Carson, Shiaoman Chao, Tyler Tiede, Jochum Wiersma, Shahryar F Kianian
Oat crown rust is one of the most damaging diseases of oat. We identified a new source of resistance and developed KASP and TaqMan markers for selection in breeding programs. A new highly effective resistance to oat crown rust (Puccinia coronata f. sp. avenae) was identified in the diploid oat Avena strigosa PI 258731 and introgressed into hexaploid cultivated oat. Young plants with this resistance show moderate susceptibility, whereas older plant tissues and adult plants are resistant with no virulent isolates encountered in over 8 years of testing...
December 6, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
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