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https://www.readbyqxmd.com/read/29156868/a-nationwide-evaluation-of-off-label-drug-utilization-in-turkey
#1
Emine Nur Özdamar, Ahmet Akıcı, Ali Alkan, Banu Bayar, Hakkı Gürsöz
Background/aim: Off-label drug use (OLDU) is under the control of the Turkish Medicines and Medical Devices Agency (TMMDA) in Turkey. It was aimed to investigate demographic and medical features of patients with OLDU applications in Turkey. Materials and methods: A total of 4426 electronic OLDU application records of the TMMDA were evaluated retrospectively. Information regarding patients? demographic characteristics, diagnoses, requested drugs, institutions, and specialties of the physicians were evaluated...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156269/autotrophic-denitrification-supported-by-biotite-dissolution-in-crystalline-aquifers-2-transient-mixing-and-denitrification-dynamic-during-long-term-pumping
#2
Clément Roques, Luc Aquilina, Alexandre Boisson, Virginie Vergnaud-Ayraud, Thierry Labasque, Laurent Longuevergne, Marc Laurencelle, Alexis Dufresne, Jean-Raynald de Dreuzy, Hélène Pauwels, Olivier Bour
We investigated the mixing and dynamic of denitrification processes induced by long-term pumping in the crystalline aquifer of Ploemeur (Brittany, France). Hydrological and geochemical parameters have been continuously recorded over 15 boreholes in 5km(2) on a 25-year period. This extensive spatial and temporal monitoring of conservative as well as reactive compounds is a key opportunity to identify aquifer-scale transport and reactive processes in crystalline aquifers. Time series analysis of the conservative elements recorded at the pumped well were used to determine mixing fractions from different compartments of the aquifer on the basis of a Principal Component Analysis approach coupled with an end-member mixing analysis...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156147/electromagnetic-navigational-bronchoscopy-versus-ct-guided-percutaneous-sampling-of-peripheral-indeterminate-pulmonary-nodules-a-cohort-study
#3
Kavita M Bhatt, Yasmeen K Tandon, Ruffin Graham, Charles T Lau, Jason K Lempel, Joseph T Azok, Peter J Mazzone, Erika Schneider, Nancy A Obuchowski, Michael A Bolen
Purpose To compare the diagnostic yield and complication rates of electromagnetic navigational bronchoscopic (ENB)-guided and computed tomography (CT)-guided percutaneous tissue sampling of lung nodules. Materials and Methods Retrospectively identified were 149 patients sampled percutaneously with CT guidance and 146 patients who underwent ENB with transbronchial biopsy of a lung lesion between 2013 and 2015. Clinical data, incidence of complications, and nodule pathologic analyses were assessed through electronic medical record review...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29156146/effectiveness-of-a-staged-us-and-unenhanced-mr-imaging-algorithm-in-the-diagnosis-of-pediatric-appendicitis
#4
Elizabeth H Dibble, David W Swenson, Claudia Cartagena, Grayson L Baird, Thaddeus W Herliczek
Purpose To establish, in a large cohort, the diagnostic performance of a staged algorithm involving ultrasonography (US) followed by conditional unenhanced magnetic resonance (MR) imaging for the imaging work-up of pediatric appendicitis. Materials and Methods A staged imaging algorithm in which US and unenhanced MR imaging were performed in pediatric patients suspected of having appendicitis was implemented at the authors' institution on January 1, 2011, with US as the initial modality followed by unenhanced MR imaging when US findings were equivocal...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29155848/an-electronic-health-record-based-model-predicts-statin-adherence-ldl-cholesterol-and-cardiovascular-disease-in-the-united-states-military-health-system
#5
Joseph E Lucas, Taylor C Bazemore, Celan Alo, Patrick B Monahan, Deepak Voora
HMG-CoA reductase inhibitors (or "statins") are important and commonly used medications to lower cholesterol and prevent cardiovascular disease. Nearly half of patients stop taking statin medications one year after they are prescribed leading to higher cholesterol, increased cardiovascular risk, and costs due to excess hospitalizations. Identifying which patients are at highest risk for not adhering to long-term statin therapy is an important step towards individualizing interventions to improve adherence. Electronic health records (EHR) are an increasingly common source of data that are challenging to analyze but have potential for generating more accurate predictions of disease risk...
2017: PloS One
https://www.readbyqxmd.com/read/29155701/an-ultrasonic-tool-for-nerve-conduction-block-in-diabetic-rat-models
#6
Yee Fun Lee, Chou-Ching Lin, Jung-Sung Cheng, Gin-Shin Chen
Nerve conduction block with a high intensity-focused ultrasound (HIFU) transducer has been performed in normal and diabetic animal models recently. HIFU can reversibly block the conduction of peripheral nerves without damaging the nerves while using an appropriate ultrasonic parameter. Temporary and partial block of the action potentials of nerves shows that HIFU has the potential to be a useful clinical treatment for pain relief. This work demonstrates the procedures for suppressing the action potentials of neuropathic nerves in diabetic rats in vivo using an HIFU transducer...
October 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155639/when-machines-think-radiology-s-next-frontier
#7
Keith J Dreyer, J Raymond Geis
Artificial intelligence (AI), machine learning, and deep learning are terms now seen frequently, all of which refer to computer algorithms that change as they are exposed to more data. Many of these algorithms are surprisingly good at recognizing objects in images. The combination of large amounts of machine-consumable digital data, increased and cheaper computing power, and increasingly sophisticated statistical models combine to enable machines to find patterns in data in ways that are not only cost-effective but also potentially beyond humans' abilities...
December 2017: Radiology
https://www.readbyqxmd.com/read/29155555/medication-exposure-in-highly-adherent-psychiatry-patients
#8
Jeffrey J Sutherland, Thomas M Daly, Karen Jacobs, Elias A Khawam, Leo Pozuelo, Ryan D Morrison, Stephen B Milne, J Scott Daniels, Timothy Patrick Ryan
Medication exposure is dependent upon many factors, the single most important being if the patient took the prescribed medication as indicated. To assess medication exposure for psychotropic and other medication classes, we enrolled 115 highly adherent psychiatry patients prescribed five or more medications. In these patients, we measured 21 psychotropic and 38 non-psychotropic medications comprising a 59-medication multiplex assay panel. Strict enrollment criteria and reconciliation of the electronic health record medication list prior to study initiation produced a patient cohort that was compliant with 91% of their prescribed medications as determined by comparing medications detected empirically in blood to the electronic health record medication list...
November 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29155251/the-rothman-index-as-a-predictor-of-post-discharge-adverse-events-after-elective-spine-surgery
#9
Ryan P McLynn, Nathaniel T Ondeck, Jonathan J Cui, David R Swanson, Blake N Shultz, Patawut Bovonratwet, Jonathan N Grauer
BACKGROUND CONTEXT: The Rothman Index (RI) is a comprehensive rating of overall patient condition in the hospital setting. It is used at many medical centers and calculated based on vital signs, lab values, and nursing assessments in the electronic medical record. Past research has demonstrated an association with adverse events, readmission, and mortality in other fields, but it has not been investigated in spine surgery. PURPOSE: To determine the potential utility of the RI as a predictor of adverse events after discharge following elective spine surgery...
November 15, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29154919/patient-reported-outcomes-and-opioid-use-by-outpatient-cancer-patients
#10
N Moryl, V Dave, P Glare, A Bokhari, V T Malhotra, A Gulati, J Hung, V Puttanniah, Y Griffo, R Tickoo, A Wiesenthal, S D Horn, C E Inturrisi
The Memorial Sloan-Kettering Pain Registry contains patient characteristics, treatments, and outcomes for a prospective cohort of 1534 chronic pain cancer patients who were seen at outpatient pain service clinics. Average pain intensity (Brief Pain Inventory) was reported as mild by 24.6% of patients, moderate by 41.5%, and severe by 33.9%. The patient's report of average percent pain relief and health state (EQ-5D) was inversely related to average pain intensity category, while measures of pain interference, number of worst pain locations, and physical and psychological distress were directly related to pain intensity category...
November 14, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29154849/spinal-anesthesia-is-associated-with-lower-recurrence-rates-after-resection-of-non-muscle-invasive-bladder-cancer
#11
Yuri Koumpan, Melanie Jaeger, Glenio Bitencourt Mizubuti, Rob Tanzola, Kunal Jain, Gregory Hosier, Wilma Hopman, D Robert Siemens
PURPOSE: To determine if anesthetic type (general vs. spinal) would influence cancer recurrence following transurethral resections of bladder tumors. MATERIALS & METHODS: With institutional ethics board approval, electronic medical records of all patients who underwent a transurethral bladder tumor resection for non-muscle invasive urothelial bladder cancer between 2011-2013 at a single tertiary care centre were examined. Follow-up information was gathered for all patients in December 2016...
November 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29154602/how-do-tobacco-power-walls-influence-adolescents-a-study-of-mediating-mechanisms
#12
Claude M Setodji, Steven C Martino, Min Gong, Michael S Dunbar, Daniela Kusuke, Angela Sicker, William G Shadel
OBJECTIVES: Tobacco power walls display hundreds of tobacco products and are known to be a key part of the impact of point-of-sale tobacco advertising on risk for smoking in adolescents. The current study examined factors that are hypothesized to mediate the effect of tobacco power wall exposure on adolescents' susceptibility for smoking in the future. METHOD: Participants (N = 148) aged 11-17 years were invited to shop in the RAND StoreLab, a life-sized replica of a convenience store...
November 20, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29154566/the-temporal-interplay-of-self-esteem-instability-and-affective-instability-in-borderline-personality-disorder-patients-everyday-lives
#13
Philip S Santangelo, Iris Reinhard, Susanne Koudela-Hamila, Martin Bohus, Jana Holtmann, Michael Eid, Ulrich W Ebner-Priemer
Borderline personality disorder (BPD) is defined by a pervasive pattern of instability. Although there is ample empirical evidence that unstable self-esteem is associated with a myriad of BPD-like symptoms, self-esteem instability and its temporal dynamics have received little empirical attention in patients with BPD. Even worse, the temporal interplay of affective instability and self-esteem instability has been neglected completely, although it has been hypothesized recently that the lack of specificity of affective instability in association with BPD might be explained by the highly intertwined temporal relationship between affective and self-esteem instability...
November 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29153922/e-health-in-switzerland-the-laborious-adoption-of-the-federal-law-on-electronic-health-records-ehr-and-health-information-exchange-hie-networks
#14
Carlo De Pietro, Igor Francetic
Within the framework of a broader e-health strategy launched a decade ago, in 2015 Switzerland passed a new federal law on patients' electronic health records (EHR). The reform requires hospitals to adopt interoperable EHRs to facilitate data sharing and cooperation among healthcare providers, ultimately contributing to improvements in quality of care and efficiency in the health system. Adoption is voluntary for ambulatories and private practices, that may however be pushed towards EHRs by patients. The latter have complete discretion in the choice of the health information to share...
November 10, 2017: Health Policy
https://www.readbyqxmd.com/read/29153691/hypertension-and-patterns-of-induced-labor-at-term
#15
Julia M Bregand-White, Michelle A Kominiarek, Judith U Hibbard
OBJECTIVE: To study patterns of induced labor at term in hypertensive women. STUDY DESIGN: We performed a retrospective cohort study using the Consortium on Safe Labor database; a multicenter study of labor and delivery practices from electronic medical records in 19 hospitals. 55,572 women were studied: 28,254 nulliparas and 27,318 multiparas, undergoing induction of labor at term without a prior cesarean with a singleton vertex live born fetus. Four hypertensive groups were defined: chronic hypertension (n=1164), gestational hypertension (n=1861), preeclampsia (n=1513) and superimposed preeclampsia (n=655), compared to controls (no hypertension, n=50,379)...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153098/high-amplification-levels-of-mdm2-and-cdk4-correlate-with-poor-outcome-in-patients-with-dedifferentiated-liposarcoma-a-cytogenomic-microarray-analysis-of-47-cases
#16
Robert W Ricciotti, Aaron J Baraff, George Jour, McKenna Kyriss, Yu Wu, Yuhua Liu, Shao-Chun Li, Benjamin Hoch, Yajuan J Liu
Dedifferentiated liposarcoma (DDLS) is characterized at the molecular level by amplification of genes within 12q13-15 including MDM2 and CDK4. However, other than FNCLCC grade, prognostic markers are limited. We aim to identify molecular prognostic markers for DDLS to help risk stratify patients. To this end, we studied 49 cases of DDLS in our institutional archives and performed cytogenomic microarray analysis on 47 cases. Gene copy numbers for 12 loci were evaluated and correlated with outcome data retrieved from our institutional electronic medical records...
December 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29153041/association-of-procalcitonin-values-and-bacterial-infections-in-pediatric-patients-receiving-extracorporeal-membrane-oxygenation
#17
Vi Ean Tan, Wayne S Moore, Arun Chopra, Jeffrey J Cies
OBJECTIVE: There is increasing data in pediatrics demonstrating procalcitonin (PCT) is more sensitive and specific than other biomarkers in the setting of bacterial infections. However, the use of PCT in neonatal and pediatric extracorporeal membrane oxygenation (ECMO) is not well described. Therefore, the purpose of this study was to describe the clinical utility of PCT in determining the absence or presence of bacterial infections in neonatal and pediatric patients on ECMO. METHODS: This was a retrospective electronic medical record (EMR) review of data between January 1, 2010 to June 30, 2016 at a single, free-standing, children 's hospital...
November 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29152808/observational-safety-study-of-specific-outcomes-after-trivalent-cell-culture-seasonal-influenza-vaccination-optaflu-%C3%A2-among-adults-in-thin-database-of-electronic-uk-primary-healthcare-records
#18
Gillian C Hall, Paul T G Davies, M Yousuf Karim, Mendel D M Haag, Caroline O'Leary
PURPOSE: To investigate the safety of trivalent seasonal influenza vaccine (TIVc) (Optaflu(®) ), the first cell culture seasonal trivalent influenza vaccine available in Europe. METHODS: Codes and unstructured text in adult electronic healthcare records (The Health Improvement Network) were searched for a TIVc brand name or batch number and possible outcomes within a 3 month pre- to 6 month post-TIVc exposure study period (2012-2015). The outcomes were severe allergic reactions, Bell's palsy, convulsions, demyelination, paresthesia, noninfectious encephalitis, neuritis (optic and brachial), vasculitis, inflammatory bowel disease, and thrombocytopenia...
November 20, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29152535/time-zero-determination-for-fel-pump-probe-studies-based-on-ultrafast-melting-of-bismuth
#19
S W Epp, M Hada, Y Zhong, Y Kumagai, K Motomura, S Mizote, T Ono, S Owada, D Axford, S Bakhtiarzadeh, H Fukuzawa, Y Hayashi, T Katayama, A Marx, H M Müller-Werkmeister, R L Owen, D A Sherrell, K Tono, K Ueda, F Westermeier, R J D Miller
A common challenge for pump-probe studies of structural dynamics at X-ray free-electron lasers (XFELs) is the determination of time zero (T0)-the time an optical pulse (e.g., an optical laser) arrives coincidently with the probe pulse (e.g., a XFEL pulse) at the sample position. In some cases, T0 might be extracted from the structural dynamics of the sample's observed response itself, but generally, an independent robust method is required or would be superior to the inferred determination of T0. In this paper, we present how the structural dynamics in ultrafast melting of bismuth can be exploited for a quickly performed, reliable and accurate determination of T0 with a precision below 20 fs and an overall experimental accuracy of 50 fs to 150 fs (estimated)...
September 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/29151840/adherence-with-epinephrine-autoinjector-prescriptions-in-primary-care
#20
Elissa M Abrams, Alexander G Singer, Lisa Lix, Alan Katz, Marina Yogendran, F Estelle R Simons
Background: The aim of this study was to estimate primary adherence for epinephrine autoinjector (EA) prescriptions in primary care practices in Manitoba, Canada. Methods: A retrospective analysis of electronic medical record and administrative data was performed to determine primary adherence, defined as dispensation of a new EA prescription within 90 days of the date the prescription was written. Multivariable logistic regression models were used to test predictors of filling an EA prescription...
2017: Allergy, Asthma, and Clinical Immunology
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