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Gustavo Deza, Begoña García-Bravo, Juan F Silvestre, Maria A Pastor-Nieto, Ricardo González-Pérez, Felipe Heras-Mendaza, Pedro Mercader, Virginia Fernández-Redondo, Bo Niklasson, Ana M Giménez-Arnau
BACKGROUND: Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens. OBJECTIVES: To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients...
November 29, 2016: Contact Dermatitis
Maartje C M Schouten, Henk F van Stel, Theo J M Verheij, Edward E S Nieuwenhuis, Elise M van de Putte
BACKGROUND: Child abuse is often unrecognized at out-of-hours primary care (OOH-PC) services. The aim of our study was to evaluate the clinical outcome of the screening instrument SPUTOVAMO-R2 for child abuse (checklist), followed by a structured approach (reporting code), at OOH-PC services. The reporting code with five steps should ensure consistent action in case of a suspicion. METHODS: All children attending one of the five participating OOH-PC services in the region of Utrecht, the Netherlands, in a year time, were included...
November 8, 2016: BMC Family Practice
Gail N Hayward, Charles Vincent, Daniel S Lasserson
BACKGROUND: Accurate assessment of the need for admission is challenging in out-of-hours (OOH) primary care. Understanding more about patient contacts where the decision to continue care in the community may have been incorrect could assist clinicians in assessing clinical risk. AIM: To define the population contacting OOH primary care who are at higher risk of re-presenting to this service and requiring urgent transfer to secondary care within 3 days of their initial contact...
November 7, 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Josep M Anglada, Ramon Crehuet, Joseph S Francisco
High-level ab initio and Born-Oppenheimer molecular dynamic calculations have been carried out on a series of hydroperoxyalkyl (α-QOOH) radicals with the aim of investigating the stability and unimolecular decomposition mechanism into QO+OH of these species. Dissociation was shown to take place through rotation of the C-O(OH) bond rather than through elongation of the CO-OH bond. Through the C-O(OH) rotation, the unpaired electron of the radical overlaps with the electron density on the O-OH bond, and from this overlap the C=O π bond forms and the O-OH bond breaks spontaneously...
November 3, 2016: Chemistry: a European Journal
Morten Bondo Christensen, Karen Busk Nørøxe, Grete Moth, Peter Vedsted, Linda Huibers
OBJECTIVE: General practitioners are the first point of contact in Danish out-of-hours (OOH) primary care. The large number of contacts implies that prescribing behaviour may have considerable impact on health-care expenditures and quality of care. The aim of this study was to examine the prevailing practices for medication prescription in Danish OOH with a particular focus on patient characteristics and contact type. DESIGN AND SETTING: A one-year population-based retrospective observational study was performed of all contacts to OOH primary care in the Central Denmark Region using registry data...
November 2, 2016: Scandinavian Journal of Primary Health Care
Edward I Solomon, Serra Goudarzi, Kyle D Sutherlin
The non-heme Fe enzymes are ubiquitous in nature and perform a wide range of functions involving O2 activation. These had been difficult to study relative to heme enzymes; however, spectroscopic methods have now been developed that provide significant insight into the correlation of structure with function. This Current Topics article summarizes both the molecular mechanism these enzymes use to control O2 activation in the presence of cosubstrates and the oxygen intermediates these reactions generate. Three types of O2 activation are observed...
October 28, 2016: Biochemistry
B B Xiao, X B Jiang, X L Yang, Q Jiang, F Zheng
Pt1ML/Pd3Al, which comprises a Pd3Al core protected by a Pt monolayer, may experience Al dealloying because of the strong affinity of Al toward O. To circumvent this issue, the Pt2ML/Os/Pd3Al catalyst has been designed to suppress the migration of Al by inserting an Os monolayer at the interface between the Pd3Al core and two Pt monolayers. On the basis of segregation energies, Al leaching from the core to the 1st layer is determined to be endothermic even under O coverage, indicating an energetic preference for Al to reside in the core structure...
October 25, 2016: Physical Chemistry Chemical Physics: PCCP
Chenggang Ci, Hongsheng Liu, Likai Yan, Zhongmin Su
Aqua-coordinated sandwich-type polyoxometalates (POMs), {[WZnTM2(H2O)2](ZnW9O34)2} (n-) (TM=Rh(III), Pd(II), and Pt(II)), catalyze olefin epoxidation with hydrogen peroxide and have been well established, and they present an advance toward the utilization of olefins. To elucidate the epoxidation mechanism, we systematically performed density functional calculations. The reaction proceeds through a two-step mechanism: activation of H2O2 and oxygen transfer. The aqua-coordinated complexes show two distinct H2O2 activation pathways: "two-step" and "concerted"...
October 2016: ChemistryOpen
Annelies Colliers, Roy Remmen, Marie-Luise Streffer, Barbara Michiels, Stefaan Bartholomeeusen, Koenraad G Monsieurs, Jef Goris, Samuel Coenen, Veronique Verhoeven, Hilde Philips
BACKGROUND: The implementation of general practitioner cooperatives (GPC) for out-of-hours (OOH) primary care, raises the question if the location of a GPC adjacent to a hospital reduces the OOH caseload of the emergency department (ED). METHODS: Two natural experiments were used in this before-after study, the effect of the implementation of two GPCs in two different regions on the out-of-hours caseload of the local EDs was compared. One GPC was located adjacent to the ED of a general hospital, the other was not...
October 17, 2016: Acta Clinica Belgica
Chun-Chieh Wang, Hao-Ching Chang, Yei-Chen Lai, Huayi Fang, Chieh-Chin Li, Hung-Kai Hsu, Zong-Yan Li, Tien-Sung Lin, Ting-Shen Kuo, Frank Neese, Shengfa Ye, Yun-Wei Chiang, Ming-Li Tsai, Wen-Feng Liaw, Way-Zen Lee
Bubbling O2 into a THF solution of Co(II)(BDPP) (1) at -90 °C generates an O2 adduct, Co(BDPP)(O2) (3). The resonance Raman and EPR investigations reveal that 3 contains a low spin cobalt(III) ion bound to a superoxo ligand. Significantly, at -90 °C, 3 can react with 2,2,6,6-tetramethyl-1-hydroxypiperidine (TEMPOH) to form a structurally characterized cobalt(III)-hydroperoxo complex, Co(BDPP)(OOH) (4) and TEMPO(•). Our findings show that cobalt(III)-superoxo species are capable of performing hydrogen atom abstraction processes...
October 11, 2016: Journal of the American Chemical Society
Sloan Ayers, Tamas Benkovics, Jonathan Marshall, Yichen Tan, Neil A Strotman, Susanne Kiau
Three major degradation products resulted from the exposure of betulonaldehyde (1) to air in solution at room temperature. From HRMS and NMR data, the products, which were isolated by preparative supercritical fluid chromatography (SFC), were identified as betulonic acid (2) and C-17 hydroperoxide epimers 3 (β-OOH) and 4 (α-OOH). For 3 and 4, the H-18 multiplet pattern of the isolated products established the configuration at C-17.
September 29, 2016: Journal of Natural Products
Dan Todkill, Helen E Hughes, Alex J Elliot, Roger A Morbey, Obaghe Edeghere, Sally Harcourt, Tom Hughes, Tina Endericks, Brian McCloskey, Mike Catchpole, Sue Ibbotson, Gillian Smith
: Introduction In preparation for the London 2012 Olympic Games, existing syndromic surveillance systems operating in England were expanded to include daily general practitioner (GP) out-of-hours (OOH) contacts and emergency department (ED) attendances at sentinel sites (the GP OOH and ED syndromic surveillance systems: GPOOHS and EDSSS). Hypothesis/Problem The further development of syndromic surveillance systems in time for the London 2012 Olympic Games provided a unique opportunity to investigate the impact of a large mass-gathering event on public health and health services as monitored in near real-time by syndromic surveillance of GP OOH contacts and ED attendances...
December 2016: Prehospital and Disaster Medicine
Hamde Nazar, Zachariah Nazar, Jill Simpson, Andre Yeung, Cate Whittlesea
OBJECTIVES: To demonstrate the contribution of community pharmacy from NHS 111 referrals out of hours (OOH) for emergency supply repeat medication requests via presentation of service activity, community pharmacist feedback and lean thinking transformation. DESIGN: Descriptive service evaluation using routine service activity data over the pilot period; survey of community pharmacists, and service redesign through lean thinking transformation. SETTING: North East of England NHS 111 provider and accredited community pharmacies across the North East of England...
2016: BMJ Open
Xiaomei Gao, Shujiao Wang, Sen Lin
Defective hexagonal boron nitride nanosheets (h-BNNSs) supported by Ni(111) and Cu(111) surfaces have been systematically studied in this work by first-principles methods. The calculation results show that various defects play an important role in enhancing the stability of h-BNNS/metal heterostructure. Importantly, significant electron transfer through the interface between metal substrate and h-BNNS to the defect sites can make h-BNNS more catalytically active. Using the oxygen reduction reaction (ORR) as a probe, it is shown that the binding energies of O2*, OH*, OOH*, and O* on h-BNNS/Cu(111) with a boron vacancy (VB) are quite similar to those observed on the Pt(111) surface, suggesting inert h-BNNS materials with defects can be functionalized by metal surfaces to become catalytically active for the ORR process...
September 14, 2016: ACS Applied Materials & Interfaces
Richmond Lee, Michelle L Coote
Accurate quantum chemical calculations were employed to investigate the mechanism of ozone-initiated oxidation of C-H bonds of saturated hydrocarbons and polymers. Step wise hydrogen atom abstraction generates the first resting state the trihydroxide -COOOH, which undergoes decomposition to produce the free radical species alkoxyl -CO˙ and peroxyl ˙OOH thereby setting off a complex chain of radical processes. The H transfer from peroxyl radical to alkoxyl allows formation of inactive alcohol and the singlet excited dioxygen...
September 21, 2016: Physical Chemistry Chemical Physics: PCCP
Maria Moss, Celine Bilbul, Jo Crook
INTRODUCTION: National guidance from National Institute for Health and Clinical Excellence (NICE), National Patient Safety Agency (NPSA), World Health Organization and the Royal Pharmaceutical Society has long highlighted the importance of accurate and timely medicines reconciliation (MR) in reducing medication errors for patients upon transfer of care setting.1 (-) 4 Current guidance for MR excludes children <16 years of age, where widespread use of off-label and unlicensed formulations puts this group of patients at a higher risk...
September 2016: Archives of Disease in Childhood
Jean Teare, Maria Horne, Gill Clements, Mohammed A Mohammed
AIMS AND OBJECTIVES: To compare and contrast job descriptions for nursing roles in out-of-hours services to obtain a general understanding of what is required for a nurse working in this job. BACKGROUND: Out-of-hours services provide nursing services to patients either through telephone or face-to-face contact in care centres. Many of these services are newly created giving job opportunities to nurses working in this area. It is vital that nurses know what their role entails but also that patients and other professionals know how out-of-hours nurses function in terms of competence and clinical role...
August 17, 2016: Journal of Clinical Nursing
Maria Paola Scapinello, Andrea Posocco, Irene De Ronch, Francesco Castrogiovanni, Gianluca Lollo, Guglielmo Sergi, Iginio Tomaselli, Loris Tonon, Marco Solmi, Stefano Traversa, Vincenzo Zambianco, Nicola Veronese
BACKGROUND: Out of hours (OOH) doctors could manage many cases limiting the inappropriate accesses to ED. However the possible determinants of referral to ED by OOH doctors are poorly studied. We aimed to characterize patients referred from the OOH to ED service in order to explore the gate-keeping role of OOH service for hospital emergency care and to facilitate future research in improving its cost-effectiveness. METHODS: A retrospective study was made through data collection of 5217 contacts in a local OOH service in the North-East of Italy (from 10/01/2012 to 03/31/2013)...
September 2016: Health Policy
K H Chua, Y Y Ooh, H C Chai
Tumour necrosis factor superfamily 4 (TNFSF4) gene has been reported to be associated with systemic lupus erythematosus (SLE) susceptibility due to its encoding for OX40L protein that can increase autoantibody production and cause imbalance of T-cell proliferation. The purpose of this study was to investigate the association of TNFSF4 rs2205960, rs1234315, rs8446748 and rs704840 with SLE in the Malaysian population. A total of 476 patients with SLE and 509 healthy controls were recruited. Real-time polymerase chain reaction (PCR) was applied to genotype the selected single nucleotide polymorphisms (SNPs)...
October 2016: International Journal of Immunogenetics
Alessandra Buja, Roberto Toffanin, S Rigon, P Sandonà, T Carrara, G Damiani, V Baldo
BACKGROUND: A growing presence of inappropriate patients has been recognised as one of the main factors influencing emergency department (ED) overcrowding, which is a very widespread problem all over the world. On the other hand, out-of-hours (OOH) physicians must avoid delaying the diagnostic and therapeutic course of patients with urgent medical conditions. The aim of this study was to analyse the appropriateness of patient management by OOH services, in terms of their potentially inappropriate referral or non-referral of non-emergency cases to the ED...
2016: BMJ Open
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