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Annelies Colliers, Roy Remmen, Marie-Luise Streffer, Barbara Michiels, Stefaan Bartholomeeusen, Koenraad G Monsieurs, Jef Goris, Samuel Coenen, Veronique Verhoeven, Hilde Philips
BACKGROUND: The implementation of general practitioner cooperatives (GPC) for out-of-hours (OOH) primary care, raises the question if the location of a GPC adjacent to a hospital reduces the OOH caseload of the emergency department (ED). METHODS: Two natural experiments were used in this before-after study, the effect of the implementation of two GPCs in two different regions on the out-of-hours caseload of the local EDs was compared. One GPC was located adjacent to the ED of a general hospital, the other was not...
October 17, 2016: Acta Clinica Belgica
Chun-Chieh Wang, Hao-Ching Chang, Yei-Chen Lai, Huayi Fang, Chieh-Chin Li, Hung-Kai Hsu, Zong-Yan Li, Tien-Sung Lin, Ting-Shen Kuo, Frank Neese, Shengfa Ye, Yun-Wei Chiang, Ming-Li Tsai, Wen-Feng Liaw, Way-Zen Lee
Bubbling O2 into a THF solution of Co(II)(BDPP) (1) at -90 °C generates an O2 adduct, Co(BDPP)(O2) (3). The resonance Raman and EPR investigations reveal that 3 contains a low spin cobalt(III) ion bound to a superoxo ligand. Significantly, at -90 °C, 3 can react with 2,2,6,6-tetramethyl-1-hydroxypiperidine (TEMPOH) to form a structurally characterized cobalt(III)-hydroperoxo complex, Co(BDPP)(OOH) (4) and TEMPO(•). Our findings show that cobalt(III)-superoxo species are capable of performing hydrogen atom abstraction processes...
October 11, 2016: Journal of the American Chemical Society
Sloan Ayers, Tamas Benkovics, Jonathan Marshall, Yichen Tan, Neil A Strotman, Susanne Kiau
Three major degradation products resulted from the exposure of betulonaldehyde (1) to air in solution at room temperature. From HRMS and NMR data, the products, which were isolated by preparative supercritical fluid chromatography (SFC), were identified as betulonic acid (2) and C-17 hydroperoxide epimers 3 (β-OOH) and 4 (α-OOH). For 3 and 4, the H-18 multiplet pattern of the isolated products established the configuration at C-17.
September 29, 2016: Journal of Natural Products
Dan Todkill, Helen E Hughes, Alex J Elliot, Roger A Morbey, Obaghe Edeghere, Sally Harcourt, Tom Hughes, Tina Endericks, Brian McCloskey, Mike Catchpole, Sue Ibbotson, Gillian Smith
: Introduction In preparation for the London 2012 Olympic Games, existing syndromic surveillance systems operating in England were expanded to include daily general practitioner (GP) out-of-hours (OOH) contacts and emergency department (ED) attendances at sentinel sites (the GP OOH and ED syndromic surveillance systems: GPOOHS and EDSSS). Hypothesis/Problem The further development of syndromic surveillance systems in time for the London 2012 Olympic Games provided a unique opportunity to investigate the impact of a large mass-gathering event on public health and health services as monitored in near real-time by syndromic surveillance of GP OOH contacts and ED attendances...
September 19, 2016: Prehospital and Disaster Medicine
Hamde Nazar, Zachariah Nazar, Jill Simpson, Andre Yeung, Cate Whittlesea
OBJECTIVES: To demonstrate the contribution of community pharmacy from NHS 111 referrals out of hours (OOH) for emergency supply repeat medication requests via presentation of service activity, community pharmacist feedback and lean thinking transformation. DESIGN: Descriptive service evaluation using routine service activity data over the pilot period; survey of community pharmacists, and service redesign through lean thinking transformation. SETTING: North East of England NHS 111 provider and accredited community pharmacies across the North East of England...
2016: BMJ Open
Xiaomei Gao, Shujiao Wang, Sen Lin
Defective hexagonal boron nitride nanosheets (h-BNNSs) supported by Ni(111) and Cu(111) surfaces have been systematically studied in this work by first-principles methods. The calculation results show that various defects play an important role in enhancing the stability of h-BNNS/metal heterostructure. Importantly, significant electron transfer through the interface between metal substrate and h-BNNS to the defect sites can make h-BNNS more catalytically active. Using the oxygen reduction reaction (ORR) as a probe, it is shown that the binding energies of O2*, OH*, OOH*, and O* on h-BNNS/Cu(111) with a boron vacancy (VB) are quite similar to those observed on the Pt(111) surface, suggesting inert h-BNNS materials with defects can be functionalized by metal surfaces to become catalytically active for the ORR process...
September 14, 2016: ACS Applied Materials & Interfaces
Richmond Lee, Michelle L Coote
Accurate quantum chemical calculations were employed to investigate the mechanism of ozone-initiated oxidation of C-H bonds of saturated hydrocarbons and polymers. Step wise hydrogen atom abstraction generates the first resting state the trihydroxide -COOOH, which undergoes decomposition to produce the free radical species alkoxyl -CO˙ and peroxyl ˙OOH thereby setting off a complex chain of radical processes. The H transfer from peroxyl radical to alkoxyl allows formation of inactive alcohol and the singlet excited dioxygen...
September 21, 2016: Physical Chemistry Chemical Physics: PCCP
Maria Moss, Celine Bilbul, Jo Crook
INTRODUCTION: National guidance from National Institute for Health and Clinical Excellence (NICE), National Patient Safety Agency (NPSA), World Health Organization and the Royal Pharmaceutical Society has long highlighted the importance of accurate and timely medicines reconciliation (MR) in reducing medication errors for patients upon transfer of care setting.1 (-) 4 Current guidance for MR excludes children <16 years of age, where widespread use of off-label and unlicensed formulations puts this group of patients at a higher risk...
September 2016: Archives of Disease in Childhood
J Teare, M Horne, Gill Clements, M A Mohammed
AIM: To compare and contrast job descriptions for nursing roles in out-of-hours (OOH) services to obtain a general understanding of what is required for a nurse working in this job. BACKGROUND: OOH services provide nursing services to patients either through telephone or face to face contact in care centres. Many of these services are newly created giving job opportunities to nurses working in this area. It is vital that nurses know what their role entails but also that patients and other professionals know how OOH nurses function in terms of competence and clinical role...
August 17, 2016: Journal of Clinical Nursing
Maria Paola Scapinello, Andrea Posocco, Irene De Ronch, Francesco Castrogiovanni, Gianluca Lollo, Guglielmo Sergi, Iginio Tomaselli, Loris Tonon, Marco Solmi, Stefano Traversa, Vincenzo Zambianco, Nicola Veronese
BACKGROUND: Out of hours (OOH) doctors could manage many cases limiting the inappropriate accesses to ED. However the possible determinants of referral to ED by OOH doctors are poorly studied. We aimed to characterize patients referred from the OOH to ED service in order to explore the gate-keeping role of OOH service for hospital emergency care and to facilitate future research in improving its cost-effectiveness. METHODS: A retrospective study was made through data collection of 5217 contacts in a local OOH service in the North-East of Italy (from 10/01/2012 to 03/31/2013)...
September 2016: Health Policy
K H Chua, Y Y Ooh, H C Chai
Tumour necrosis factor superfamily 4 (TNFSF4) gene has been reported to be associated with systemic lupus erythematosus (SLE) susceptibility due to its encoding for OX40L protein that can increase autoantibody production and cause imbalance of T-cell proliferation. The purpose of this study was to investigate the association of TNFSF4 rs2205960, rs1234315, rs8446748 and rs704840 with SLE in the Malaysian population. A total of 476 patients with SLE and 509 healthy controls were recruited. Real-time polymerase chain reaction (PCR) was applied to genotype the selected single nucleotide polymorphisms (SNPs)...
October 2016: International Journal of Immunogenetics
Alessandra Buja, Roberto Toffanin, S Rigon, P Sandonà, T Carrara, G Damiani, V Baldo
BACKGROUND: A growing presence of inappropriate patients has been recognised as one of the main factors influencing emergency department (ED) overcrowding, which is a very widespread problem all over the world. On the other hand, out-of-hours (OOH) physicians must avoid delaying the diagnostic and therapeutic course of patients with urgent medical conditions. The aim of this study was to analyse the appropriateness of patient management by OOH services, in terms of their potentially inappropriate referral or non-referral of non-emergency cases to the ED...
2016: BMJ Open
Hui Li, Chun-Lei Song, Xiu-Yun Cao, Yi-Yong Zhou
To reveal phosphorus (P) release pathways from sediment and their mechanisms induced by organic matter enrichment, 116 sampling sites (including surface water and sediment) in 29 shallow lakes with different eutrophic degrees in Wuhan city, China, were investigated from July 2011 to November 2011. Empirical relationship and structural equation model indicated that the decomposition of total organic matter (TOM), including proteins (PRT), carbo-hydrates (CHO) and lipids (especially PRT) mediated by extracellular enzymes, accelerated the formation of anaerobic status...
August 5, 2016: Science of the Total Environment
Xiuli Hou, Peng Zhang, Shuang Li, Wei Liu
Developing inexpensive and non-precious metal electrocatalysts for the oxygen reduction reaction (ORR) is among the major goals in fuel cells. Herein, by using density-functional theory calculations, we show that N-doped olympicene/graphene hybrids exhibit unexpectedly high ORR catalytic activity-even comparable to that of the Pt(111) surface. Both graphitic-type and pyridine-type N-doped olympicene/graphene hybrids are highly active for the ORR and have good CO tolerance. The formation of the second H2O molecule is the rate-determining step for the ORR with the graphitic-type hybrid, whereas on the pyridine-type hybrid, it is the formation of OOH...
August 17, 2016: Physical Chemistry Chemical Physics: PCCP
F Sanfilippo, C Corredor, C Santonocito, G Panarello, A Arcadipane, G Ristagno, T Pellis
BACKGROUND: Guidelines for treatment of out-of-hospital cardiac arrest (OOH-CA) with shockable rhythm recommend amiodarone, while lidocaine may be used if amiodarone is not available. Recent underpowered evidence suggests that amiodarone, lidocaine or placebo are equivalent with respect to survival at hospital discharge, but amiodarone and lidocaine showed higher hospital admission rates. We undertook a systematic review and meta-analysis to assess efficacy of amiodarone vs lidocaine vs placebo...
October 2016: Resuscitation
Heng Wang, Joseph W Bozzelli
Oxygenated fluorocarbons are routinely found in sampling of environmental soils and waters as a result of the widespread use of fluoro and chlorofluoro carbons as heat transfer fluids, inert materials, polymers, fire retardants and solvents; the influence of these chemicals on the environment is a growing concern. The thermochemical properties of these species are needed for understanding their stability and reactions in the environment and in thermal process. Structures and thermochemical properties on the mono- to trifluoromethanol, CH3-xFxOH, and fluoromethyl hydroperoxide, CH3-xFxOOH (1 ≤ x ≤ 3), are determined by CBS-QB3, CBS-APNO, and G4 calculations...
September 8, 2016: Journal of Physical Chemistry. A
Chetna Tyagi, Archana Singh, Indrakant Kumar Singh
Various types of oxygenated fatty acids termed 'oxylipins' are involved in plant response to herbivory. Oxylipins like jasmonic acid (JA) and green leafy volatiles (GLVs) are formed by the action of enzymes like allene oxide synthase (AOS) and hydroxyperoxide lyase (HPL) respectively. In this study, we focus on AOS of Oryza sativa sb. Japonica, that interact with 9- and 13- hydroxyperoxides to produce intermediates of jasmonate pathway and compare it with rice HPL that yields GLVs. We attempt to elucidate the interaction pattern by computational docking protocols keeping the Arabidopsis AOS system as the reference model system...
July 2, 2016: Computational Biology and Chemistry
Chao Zang, Yungen Liu, Zhen-Jiang Xu, Chun-Wai Tse, Xiangguo Guan, Jinhu Wei, Jie-Sheng Huang, Chi-Ming Che
The development of environmentally benign catalysts for highly enantioselective asymmetric cis-dihydroxylation (AD) of alkenes with broad substrate scope remains a challenge. By employing [Fe(II) (L)(OTf)2 ] (L=N,N'-dimethyl-N,N'-bis(2-methyl-8-quinolyl)-cyclohexane-1,2-diamine) as a catalyst, cis-diols in up to 99.8 % ee with 85 % isolated yield have been achieved in AD of alkenes with H2 O2 as an oxidant and alkenes in a limiting amount. This "[Fe(II) (L)(OTf)2 ]+H2 O2 " method is applicable to both (E)-alkenes and terminal alkenes (24 examples >80 % ee, up to 1 g scale)...
August 22, 2016: Angewandte Chemie
Camilla Kjellstadli Thoresen, Hogne Sandvik, Steinar Hunskaar
OBJECTIVE: To investigate how cancer patients in Norway use primary care out-of-hours (OOH) services and describe different contact types and procedures. DESIGN: A retrospective cross-sectional registry study using a billing registry data source. SETTING: Norwegian primary care OOH services in 2014. SUBJECTS: All patients' contacts in OOH services in 2014. Cancer patients were identified by ICPC-2 diagnosis. MAIN OUTCOME MEASURES: Frequency of cancer patients' contacts with OOH services, contact types, diagnoses, procedures, and socio-demographic characteristics...
September 2016: Scandinavian Journal of Primary Health Care
Yongcai Qiu, Wei Liu, Wei Chen, Wei Chen, Guangmin Zhou, Po-Chun Hsu, Rufan Zhang, Zheng Liang, Shoushan Fan, Yuegang Zhang, Yi Cui
Bismuth vanadate (BiVO4) has been widely regarded as a promising photoanode material for photoelectrochemical (PEC) water splitting because of its low cost, its high stability against photocorrosion, and its relatively narrow band gap of 2.4 eV. However, the achieved performance of the BiVO4 photoanode remains unsatisfactory to date because its short carrier diffusion length restricts the total thickness of the BiVO4 film required for sufficient light absorption. We addressed the issue by deposition of nanoporous Mo-doped BiVO4 (Mo:BiVO4) on an engineered cone-shaped nanostructure, in which the Mo:BiVO4 layer with a larger effective thickness maintains highly efficient charge separation and high light absorption capability, which can be further enhanced by multiple light scattering in the nanocone structure...
June 2016: Science Advances
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