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Intratympanic steroids

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https://www.readbyqxmd.com/read/29764271/effect-of-intratympanic-steroid-injection-in-light-cupula
#1
Jin Su Park, So Yean Kim, Min-Beom Kim
OBJECTIVE: To evaluate the effects of intratympanic steroid injection (ITS) in light cupula. METHODS: A total of 47 patients showing persistent geotropic direction-changing positional nystagmus with null point (light cupula) were randomly classified into three groups: ITS (n = 15), vestibular suppressant (VS, n = 16) and canalith repositioning procedure (CRP, n = 16). Positional nystagmus and dizziness severity by dizziness handicap inventory (DHI) and visual analogue scale (VAS) were conducted before and 3 d and 1 week after first treatment to compare the effect of each treatment...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29721537/oral-and-intratympanic-steroid-therapy-for-idiopathic-sudden-sensorineural-hearing-loss
#2
Jared H Hara, Julia A Zhang, Krupa R Gandhi, Anna Flaherty, Wayne Barber, Marcia A Leung, Lawrence P Burgess
Objective: To investigate the role of intratympanic (IT) therapy in the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: This study was a retrospective review. Patients were treated for ISSNHL from January 1, 2011 to April 12, 2015 with the following: pre/posttreatment audios, treatment initiated ≤90 days and idiopathic etiology. Fifty-three ISSNHL patients were analyzed in the following subgroups: oral steroids (n = 8), combination oral+IT (n = 39), and IT (n = 6)...
April 2018: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29649042/factors-associated-with-the-benefits-of-concurrent-administration-of-intratympanic-steroid-injection-with-oral-steroids-in-patients-with-acute-acoustic-trauma
#3
Young-Soo Chang, Kanghyun Bang, Nayeon Choi, Jong Sei Kim, Gang-Gyu Lee
OBJECTIVE: To analyze the factors associated with the benefits of concurrent administration of intratympanic steroid injection (ITSI) and oral steroids in patients with acute acoustic trauma (AAT) incurred during military training. STUDY DESIGN: Retrospective analysis. PATIENTS: Nineteen patients eligible under the criteria established concerning treatment for AAT were retrospectively reviewed in this study. INTERVENTIONS: ITSI treatments were administered simultaneously alongside oral prednisolone...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29619108/the-effects-of-experimental-intratympanic-steroid-administration-on-organ-of-corti-type-1-spiral-ganglion
#4
Turgay Topcuoglu, Murat Kocyıgıt, Erdogan Bulut, Safiye G Ortekın, Mehmet Kanter, Recep Yagız
Introduction  It is unclear how effective is the intratympanic (IT) steroid treatment on organ of Corti type 1 spiral ganglion, its optimal dosage and frequency of administration. The effect of dexamethasone on cochlear functions in individuals with a normal hearing ability is also unknown. Objective  The aim of this study was to evaluate, at the electrophysiological and ultrastructural levels, the effect of IT dexamethasone administration in guinea pigs with normal hearing on organ of Corti type 1 spiral ganglion...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29605865/intratympanic-steroid-use-for-idiopathic-sudden-sensorineural-hearing-loss-current-otolaryngology-practice-in-germany-and-austria
#5
L Sutton, V Schartinger, C Url, J Schmutzhard, D Lechner, C Kavasogullari, J S Sandhu, A Shaida, R Laszig, J Loehler, S Plontke, H Riechelmann, M Lechner
AIMS: The frequency of the use of intratympanic steroids (ITS) as a treatment for idiopathic sudden sensorineural hearing loss (ISSNHL) in Europe is still unknown and remains a contentious issue amongst otolaryngologists. We undertook a survey of otolaryngologists in Germany and Austria to establish if there is any professional consensus with which to form a protocol for its use. METHODS: A survey of 21 questions was distributed electronically to otolaryngologists in Germany and Austria and data on demographics, indications for intratympanic treatment, procedure, follow-up, and outcomes were analysed...
May 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29601595/effects-of-dexamethasone-on-intracochlear-inflammation-and-residual-hearing-after-cochleostomy-a-comparison-of-administration-routes
#6
Ah-Ra Lyu, Dong Hyun Kim, Seung Hun Lee, Dong-Sik Shin, Sun-Ae Shin, Yong-Ho Park
Preservation of residual hearing after cochlear implant is an important issue with regards to hearing performance. Various methods of steroid administration have been widely used in clinical practice to reduce inflammation and preserve residual hearing. Here we compare the effect of different routes of dexamethasone administration on intracochlear inflammation and residual hearing in guinea pig ears. Dexamethasone was delivered into the guinea pigs either through intracochlear, intratympanic or systemic route...
2018: PloS One
https://www.readbyqxmd.com/read/29551306/pharmacokinetic-principles-in-the-inner-ear-influence-of-drug-properties-on-intratympanic-applications
#7
REVIEW
Alec N Salt, Stefan K Plontke
Local drug delivery to the ear has gained wide clinical acceptance, with the choice of drug and application protocol in humans largely empirically-derived. Here, we review the pharmacokinetics underlying local therapy of the ear using the drugs commonly used in clinical practice as examples. Based on molecular properties and perilymph measurements interpreted through computer simulations we now better understand the principles underlying entry and distribution of these and other drugs in the ear. From our analysis, we have determined that dexamethasone-phosphate, a pro-drug widely-used clinically, has molecular and pharmacokinetic properties that make it ill-suited for use as a local therapy for hearing disorders...
March 11, 2018: Hearing Research
https://www.readbyqxmd.com/read/29513064/contribution-of-intratympanic-steroids-in-the-primary-treatment-of-sudden-hearing-loss
#8
Hasan Demirhan, Ali Rıza Gökduman, Bahtiyar Hamit, Müge Fethiye Yürekli Altındağ, Özgür Yiğit
OBJECTIVE: The primary objective is to investigate the contribution of intratympanic steroids in the primary treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). The secondary objective is to compare methylprednisolone (MP) and dexamethasone in terms of their effectiveness and injection-site pain. METHODS: Two hundred and four patients with ISSNHL, 144 patients underwent systemic steroid therapy (SST) alone and 60 patients underwent combined therapy (CT)...
March 7, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29504828/assessment-of-the-efficacy-of-a-local-steroid-rescue-treatment-administered-2-days-after-a-moderate-noise-induced-trauma-in-guinea-pig
#9
Elisabeth Mamelle, Naila El Kechai, Victor Adenis, Yann Nguyen, Olivier Sterkers, Florence Agnely, Amélie Bochot, Jean Marc Edeline, Evelyne Ferrary
OBJECTIVES: Intratympanic injection of corticosteroids membrane after noise-induced hearing loss is an accepted alternative to general administration. We investigated the effect on hearing of a hyaluronic acid gel with liposomes loaded with dexamethasone (DexP) administered into the middle ear. METHODS: An acute acoustic trauma was performed to 13 guinea pigs for a period of 1 h on Day -2. Two 2 days after the noise trauma, the animals were then assigned randomly to four experimental groups: control without gel, gel injection, gel-containing free DexP, gel-containing DexP loaded into liposomes...
March 5, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29468101/idiopathic-sudden-sensorineural-hearing-loss-average-time-elapsed-before-presentation-to-the-otolaryngologist-and-effectiveness-of-oral-and-or-intratympanic-steroids-in-late-presentations
#10
Anwuli Anyah, Devin Mistry, Erin Kevern, Kenneth Markiewicz
Objectives To determine how long after symptom onset that the average patient with an idiopathic sudden sensorineural hearing loss (ISSNHL) presents to the otolaryngology clinic.  In late presentations, to determine the time to presentation cutoff after which intervention may not be effective.  To evaluate the effectiveness of oral steroids versus a combination of oral and intratympanic steroid therapy in late presentations of ISSNHL.  Methods and procedures Sixty-four patients met inclusion criteria after chart review of 2,037 patients seen at Metro Health Hospital from 2006 to 2016 for sensorineural hearing loss...
December 14, 2017: Curēus
https://www.readbyqxmd.com/read/29436794/the-follow-up-role-of-the-vestibular-evoked-myogenic-potential-test-in-meniere-s-disease
#11
Nasrin Yazdani, Farzaneh Nejadian, Nima Rezazadeh, Reza Hoseinabadi, Ebrahim Karimi, Reza Gharibi, Sasan Dabiri
Despite some proposed roles for the diagnostic impact of the cervical vestibular evoked myogenic potential test in the patients with Meniere's disease, the role of this test as an objective instrument in following up the patients with Meniere's disease who underwent. Intratympanic steroid injection is not cleared. In a prospective study, thirty-one adult patients with definite one-sided Meniere's disease with vertigo as main complaint refractory to medical treatments for three months, were selected. Patients underwent three times of intratympanic dexamethasone injection with one-week intervals...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29411622/comparison-of-2-and-4-intratympanic-steroid-injections-in-the-treatment-of-idiopathic-sudden-sensorineural-hearing-loss
#12
Hideaki Suzuki, Tetsuro Wakasugi, Takuro Kitamura, Hiroki Koizumi, Ba Hung Do, Toyoaki Ohbuchi
OBJECTIVE: We studied the effect of intratympanic steroid administration with different total injection times on hearing outcomes in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). METHODS: The subjects were 191 consecutive patients (192 ears) with ISSNHL (hearing level ≥40 dB, interval between onset and treatment ≤30 days). They received systemic prednisolone (100 mg followed by tapered doses) combined with intratympanic injection of dexamethasone (4 mg/ml)...
April 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29390288/intratympanic-glucocorticosteroid-therapy-for-idiopathic-sudden-hearing-loss-meta-analysis-of-randomized-controlled-trials
#13
Dan Lai, Fei Zhao, Nasim Jalal, Yun Zheng
BACKGROUND AND OBJECTIVE: Glucocorticoids are the standard treatment for idiopathic sudden sensorineural hearing loss (ISSNHL), but whether intratympanic or systemic therapy is superior remains controversial. Previous meta-analyses of this question have omitted key clinical trials or included observational studies. METHODS: English-language randomized controlled trials in OvidSP, PubMed, Embase, CINAHL, and the Cochrane Library comparing intratympanic versus systemic glucocorticoid therapy for ISSNHL were meta-analyzed using RevMan 5...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29338942/international-consensus-icon-on-treatment-of-m%C3%A3-ni%C3%A3-re-s-disease
#14
J Nevoux, M Barbara, J Dornhoffer, W Gibson, T Kitahara, V Darrouzet
OBJECTIVE: To present the international consensus for recommendations for Ménière's disease (MD) treatment. METHODS: Based on a literature review and report of 4 experts from 4 continents, the recommendations have been presented during the 21st IFOS congress in Paris, in June 2017 and are presented in this work. RESULTS: The recommendation is to change the lifestyle, to use the vestibular rehabilitation in the intercritic period and to propose psychotherapy...
February 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29227445/mobile-hearing-testing-applications-and-the-diagnosis-of-sudden-sensorineural-hearing-loss-a-cautionary-tale
#15
Rosh K V Sethi, Iman Ghanad, Vivek Kanumuri, Barbara Herrmann, Elliott D Kozin, Aaron K Remenschneider
OBJECTIVE: Mobile hearing applications (apps) are available for hearing testing, personal sound amplification, as well as hearing aid modulation. Hearing testing apps are gaining popularity, especially in resource-limited settings. The reliability of mobile hearing testing apps, however, is not well characterized. PATIENTS/INTERVENTIONS: A case study of a single patient with a complaint of sudden hearing loss presenting to a tertiary-care hospital. MAIN OUTCOME MEASURE: Comparison of a mobile hearing testing app results with standard audiogram...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29168028/systemic-intratympanic-and-combined-administration-of-steroids-for-sudden-hearing-loss-a-prospective-randomized-multicenter-trial
#16
Michael Tsounis, George Psillas, Miltiadis Tsalighopoulos, Victor Vital, Nicolas Maroudias, Konstantinos Markou
PURPOSE: The purpose of this prospective, randomized, multicenter clinical trial was to compare the therapeutic efficacy of systemic versus intratympanic versus combined administration of steroids in the treatment of idiopathic sudden sensorineural hearing loss. METHODS: 102 patients with an up to 14 days history of idiopathic sudden sensorineural hearing loss were randomized to 1 of 3 arms and followed prospectively. Group A (35 patients) received prednisolone intravenously followed by methylprednisolone orally, whereas Group B (34 patients) were administered intratympanic methylprednisolone...
January 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29110919/effects-of-intratympanic-dexamethasone-on-noise-induced-hearing-loss-an-experimental-study
#17
Sait Serdar Gumrukcu, İlhan Topaloglu, Ziya Salturk, Belgin Tutar, Yavuz Atar, Güler Berkiten, Ayşe Enise Göker
AIM: Aim of the study was to evaluate the effect of intratympanic steroid treatment on hearing based on oto-acoustic emission. METHODS: A total of 16 healthy female Wistar albino rats weighing were used in this study. They were divided in to 2 groups and each group was exposed to noise at 110dB for 25min to induce acoustic trauma. Intratympanic dexamethasone was administered to the middle ears of animals in the experimental group on the same day as exposure to noise...
January 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28888426/sudden-sensorineural-hearing-loss-in-children-and-adolescents-clinical-characteristics-and-age-related-prognosis
#18
Jin Youp Kim, Jae Joon Han, Woong Sang Sunwoo, Ja-Won Koo, Seung-Ha Oh, Min-Hyun Park, Young Ho Kim
OBJECTIVE: Although many studies have investigated sudden sensorineural hearing loss (SSNHL) in adults, there were few studies on SSNHL in the pediatric population; especially research on treatment and prognosis of pediatric SSNHL was limited. The aim of this study was to evaluate clinical characteristics, treatment outcomes and prognostic factors in children and adolescents with SSNHL. METHODS: A retrospective review of medical records of 67 pediatric patients (67 ears) who had diagnosed with SSNHL at our hospitals was performed to analyze patients' clinical manifestations and audiograms...
September 6, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28802357/evaluation-of-ototoxicity-of-intratympanic-administration-of-methotrexate-in-rats
#19
Sabri Baki Eren, Remzi Dogan, Alper Yenigun, Bayram Veyseller, Selahattin Tugrul, Orhan Ozturan, Mehmet Serif Aydin
OBJECTIVE: Methotrexate is a dihydrofolate reductase enzyme inhibitor with very high selectivity, and it is an antiproliferative folic acid antagonist used for the treatment of autoimmune diseases. In this study, our objective was to evaluate the effect of intratympanic Methotrexate application in the inner ear. METHODS: This study was planned as an animal study. This study performed in a tertiary referral center. 24 healthy female rats were used in our study. They were separated into three groups...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28756569/sudden-hearing-loss-an-effectivity-comparison-of-intratympanic-and-systemic-steroid-treatments
#20
Gülce Ermutlu, Nilda Süslü, Taner Yılmaz, Sarp Saraç
Corticosteroid treatment has been considered the most effective treatment modality for sudden sensorineural hearing loss so far. Application route of corticosteroids may vary. We have designed a prospective randomized case-controlled clinical trial to evaluate the effectivenesses of the different application routes of steroids in the treatment of SSHL. Thirty-five patients were distributed randomly to two groups which were treated with either 'oral' or 'intratympanic' corticosteroids. Intratympanic steroid administration was performed three times every other day transtympanically...
October 2017: European Archives of Oto-rhino-laryngology
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