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Intratympanic steroids

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https://www.readbyqxmd.com/read/28214024/long-term-outcomes-of-endolymphatic-sac-shunting-with-local-steroids-for-meniere-s-disease
#1
Cameron C Wick, Nauman F Manzoor, Caileigh McKenna, Maroun T Semaan, Cliff A Megerian
OBJECTIVES: To evaluate the long-term efficacy of endolymphatic sac shunt techniques with and without local steroid administration. STUDY DESIGN: Retrospective case series and patient survey. SETTING: Tertiary university hospital. PATIENTS: Meniere's disease (MD) patients that failed medical therapy and subsequently underwent an endolymphatic sac shunt procedure. All patients had definitive or probable MD and at least 18-months of follow-up...
January 20, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28207624/combined-intratympanic-and-systemic-use-of-steroids-as-a-first-line-treatment-for-sudden-sensorineural-hearing-loss-a-meta-analysis-of-randomized-controlled-trials
#2
Xue Han, Xiao Yin, Xiaodong Du, Changling Sun
OBJECTIVE: To compare the efficacy of combination therapy (combined intratympanic and systemic use of steroids, CT) with systemic steroid therapy (SST) as a primary treatment for sudden sensorineural hearing loss (SSNHL). METHODS: An electronic database search (PubMed, Embase, Cochrane Library, and CNKI databases) was performed. Review Manger 5.3 was used for data synthesis. Data were collected on the following outcomes of interest: the proportion of patients with hearing improvement, changes in pure tone averages (PTA), and speech discrimination score (SDS)...
February 15, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28125313/effects-of-early-intratympanic-steroid-injection-in-patients-with-acoustic-trauma-caused-by-gunshot-noise
#3
Young-Soo Chang, Kang Hyun Bang, Byoungseo Jeong, Gang-Gyu Lee
CONCLUSION: This study evaluated the efficacy of concurrent administration of ITSI and systemic steroids in delayed treatment of NIHL after gunshot noise exposure. The results showed additional hearing benefits with administration of ITSI. Further evaluation is warranted to confirm this efficacy. OBJECTIVE: This investigation evaluated the effects of early administration of an intratympanic steroid injection (ITSI) in combination with systemic steroids treatment in patients with acoustic trauma caused by gunshot noise...
January 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28033296/intratympanic-steroids-injection-is-effective-for-the-treatment-of-drop-attacks-with-m%C3%A3-ni%C3%A3-re-s-disease-and-delayed-endolymphatic-hydrops-a-retrospective-study
#4
Bo Liu, Yangming Leng, Renhong Zhou, Jingjing Liu, Dongdong Liu, Su-Lin Zhang, Wei-Jia Kong
Drop attack (DA) associated with Ménière's disease (MD) and delayed endolymphatic hydrops (DEH) is not common and may cause life-threatening clinical problems. The intratympanic dexamethasone (ITD) is one of primary treatments for MD or DEH. Our study investigated the effect of ITD on the DA associated with endolymphatic hydrops (EH).We retrospectively reviewed 10 patients with MD- and DEH-associated DA between January 2009 and December 2013 in Outpatient Department of Otolaryngology, Union Hospital, Wuhan, China...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27964845/intratympanic-steroid-injection-and-hyperbaric-oxygen-therapy-for-the-treatment-of-refractory-sudden-hearing-loss
#5
Filiz Gülüstan, Zahide Mine Yazıcı, Wesam M E Alakhras, Omer Erdur, Harun Acipayam, Levent Kufeciler, Fatma Tulin Kayhan
INTRODUCTION: Controversy surrounds the use of salvage therapies to treat sudden sensorineural hearing loss (SSNHL), with no consensus on recommendations. While several studies have demonstrated the effectiveness of intratympanic administration of steroids (ITS) and hyperbaric oxygen (HBO) treatment, few have compared the efficacy of ITS and HBO therapy in patients with refractory SSNHL. OBJECTIVE: We evaluated the efficiency of ITS and HBO therapy in patients with refractory SSNHL...
November 22, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27921520/a-comparison-between-systemic-and-intratympanic-steroid-therapies-as-initial-therapy-for-idiopathic-sudden-sensorineural-hearing-loss-a-meta-analysis
#6
Qingfen Qiang, Xuewen Wu, Tao Yang, Chunguang Yang, Hong Sun
CONCLUSIONS: Intratympanic steroid (ITS) treatment groups exhibited better outcomes in PTA improvement and recovery rate than systemic steroid therapy (SST) groups. Whether initial hearing loss severity would influence the PTA improvement and recovery rate still requires further research. OBJECTIVE: This article was aimed at evaluating whether intratympanic steroid (ITS) treatment would provide benefits over systemic steroid therapy (SST) as initial therapy in patients with idiopathic sudden sensorineural hearing loss (ISSHL)...
December 6, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27898607/effects-of-intratympanic-dexamethasone-on-high-dose-radiation-ototoxicity-in-vivo
#7
Christine T Dinh, Si Chen, John Dinh, Stefania Goncalves, Esperanza Bas, Kyle Padgett, Perry Johnson, Nagy Elsayyad, Fred Telischi, Thomas Van De Water
BACKGROUND: Stereotactic radiosurgery for lateral skull base tumors can cause hearing loss when the cochleae are exposed to high doses of single-fraction radiation. Currently, there are no known nondosimetric preventative treatments for radiation-induced ototoxicity. HYPOTHESIS: Intratympanic (IT) dexamethasone (DXM), a synthetic steroid, protects against radiation-induced auditory hair cell (HC) and hearing losses in rats in vivo. METHODS: Seven rats received radiation (12 Gy) to both cochleae...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27894374/autologous-intratympanic-blood-patch-for-presumed-perilymphatic-fistulas
#8
P K Foster
OBJECTIVE: To assess an alternative to bed rest and surgery for suspected perilymphatic fistulas using intratympanic blood injections. METHOD: A review was conducted of patients' history, physical and audiometric data, before and after treatment by intratympanic blood injections performed from 2009 to 2015. RESULTS: Twelve ears were identified, with trauma associated with air travel, water sports or nose blowing. Ten of these cases had hearing loss, six had vestibular symptoms...
December 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27861924/intratympanic-dexamethasone-in-sudden-sensorineural-hearing-loss-a-systematic-review-and-meta-analysis
#9
REVIEW
Nagi G El Sabbagh, Maida J Sewitch, Aren Bezdjian, Sam J Daniel
OBJECTIVE: Systemic dexamethasone has demonstrated conclusive benefits in reversing sudden sensorineural hearing loss (SSNHL) despite considerable number of potential side effects. In contrast, the intratympanic route of steroid administration averts several possible complications. This study aims to examine the literature to delineate the efficacy and side effect of intratympanic dexamethasone (ITD) injection for the treatment of SSNHL. DATA SOURCE: Cochrane, Embase, and MEDLINE electronic databases from January 1950 to August 2014, with an update performed on November 10, 2014...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27821219/effects-of-two-different-local-anaesthetic-methods-vs-no-anaesthesia-on-pain-scores-for-intratympanic-injections
#10
COMPARATIVE STUDY
N Ata, O Erdur, M H Görgülü, E Yilmaz
OBJECTIVE: This study compared the pain associated with the intratympanic injection combined with various local anaesthetics vs without anaesthesia. METHODS: The study included 40 patients (aged 18-78 years) who received intratympanic steroid injections for sudden idiopathic hearing loss or tinnitus. Each patient underwent all three injection methods at one-week intervals. Patients received one of two local anaesthetics (lidocaine injection or lidocaine spray) or no anaesthesia before intratympanic injection, and used a visual analogue scale to indicate the pain level after 5 and 45 minutes...
December 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27779563/hearing-changes-after-intratympanically-applied-steroids-for-primary-therapy-of-sudden-hearing-loss-a-meta-analysis-using-mathematical-simulations-of-drug-delivery-protocols
#11
Arne Liebau, Olivia Pogorzelski, Alec N Salt, Stefan K Plontke
OBJECTIVE: Controlled and uncontrolled studies with primary intratympanic or combined intratympanic and systemic application of glucocorticosteroids for idiopathic sudden hearing loss were analyzed by means of a meta-analysis in an attempt to establish optimal local drug delivery protocols. STUDY DESIGN: A total of 25 studies with 28 treatment groups between January 2000 and June 2014 were selected that adequately described drug delivery protocols. Cochlear drug levels were calculated by a validated computer model of drug dispersion in the inner ear fluids based on the concentration and volume of glucocorticoids applied, the time the drug remained in the middle ear, and the specific timing of injections...
January 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/27751619/rate-of-tympanic-membrane-perforation-after-intratympanic-steroid-injection
#12
Michael C Topf, David W Hsu, Douglas R Adams, Tingting Zhan, Stanley Pelosi, Thomas O Willcox, Brian McGettigan, Kyle W Fisher
PURPOSE: To determine the rate of persistent tympanic membrane perforation after intratympanic steroid injection. To determine which comorbid conditions and risk factors are associated with prolonged time to perforation closure following intratympanic steroid injection. MATERIALS AND METHODS: Clinical data were gathered for patients who had undergone intratympanic steroid injection to treat sudden sensorineural hearing loss or Ménière's disease. Primary outcomes analysis included rate of persistent tympanic membrane perforation, defined as perforation at least 90days following last injection, and time to perforation healing...
January 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27638077/meni%C3%A3-re-s-disease
#13
REVIEW
J M Espinosa-Sanchez, J A Lopez-Escamez
Menière's disease (MD) is a chronic multifactorial disorder of the inner ear characterized by episodic vestibular symptoms associated with sensorineural hearing loss, tinnitus, and aural pressure. Epidemiologic and genomic evidence supports a genetic susceptibility with multiple biochemical pathways involved, including the endocrine system, innate immune response, and autonomic nervous system. Allergens, infectious agents, vascular events, or genetic factors could modify inner-ear homeostasis and trigger MD...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27552828/successful-continual-intratympanic-steroid-injection-therapy-in-a-patient-with-refractory-sensorineural-hearing-loss-accompanied-by-relapsing-polychondritis
#14
Koichiro Wasano, Shuta Tomisato, Sayuri Yamamoto, Noriomi Suzuki, Taiji Kawasaki, Kaoru Ogawa
OBJECTIVE: To report the treatment efficacy of continual intratympanic steroid injection (ITSI) therapy in a patient with refractory sensorineural hearing loss accompanied by relapsing polychondritis. PATIENT: A 49-year-old female diagnosed with relapsing polychondritis at the age of 45 years and who had been treated with corticosteroids and immunosuppressants developed sensorineural hearing loss in the left ear. INTERVENTION: Her unilateral hearing loss did not recover despite receiving one cyclophosphamide pulse treatment, one methylprednisolone pulse treatment, and weekly leukapheresis...
August 20, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27497416/pediatric-sudden-sensorineural-hearing-loss-etiology-diagnosis-and-treatment-in-20-children
#15
Kavita Dedhia, David H Chi
OBJECTIVES: 1. To report our experience in children with sudden-onset sensorineural hearing loss (SSNHL). 2. To describe the etiology and management of children with SSNHL. METHODS: Retrospective review of 20 children with SSNHL, from 2000 to 2013 at a tertiary pediatric facility. Patients had the following inclusion criteria: history of normal hearing, hearing loss occurring in less than 3 days, and audiogram documentation. RESULTS: The average age of patients presenting with SSNHL is 11 years 3 months (22months-18years)...
September 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27413407/the-efficacy-of-adjuvant-intratympanic-steroid-treatment-for-otitis-media-with-effusion-in-children
#16
Hazem Saeed Amer, Mohammad Waheed El-Anwar, Alaa Eldin Elfeky
INTRODUCTION: Otitis media with effusion (OME) is a leading cause of hearing impairment in children. Therefore, early and proper management is essential. OBJECTIVES: The objective of this research is to assess the efficacy of intratympanic (IT) steroids injection for management of otitis media with effusion (OME). METHODS: This study involved 42 children (84 ears) with bilateral OME. We used tympanometry to confirm the childreńs middle ear effusion and pure tone audiometry to determine hearing threshold...
July 2016: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/27403406/intratympanic-dexamethasone-injection-vs-methylprednisolone-for-the-treatment-of-refractory-sudden-sensorineural-hearing-loss
#17
Nezamoddin Berjis, Saeed Soheilipour, Alireza Musavi, Seyed Mostafa Hashemi
BACKGROUND: During the past years various drugs have been used for sudden sensorineural hearing loss (SSNHL) treatment including steroids that are shown to be beneficial. Directed delivery of high doses of steroids into the inner ear is suggested for its potential and known as intratympanic steroids therapy (IST). Despite the use of dexamethasone and methylprednisolone as the traditional treatments, there are still debates about the optimal dosage, preferred drug, and the route of administration...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27392835/about-the-pathophysiology-of-acute-unilateral-vestibular-deficit-vestibular-neuritis-vn-or-peripheral-vestibulopathy-pvp
#18
Denis S Uffer, Stefan C A Hegemann
OBJECTIVE: To determine whether patients with acute unilateral peripheral vestibulopathy (PVP), often called "vestibular neuritis/neuronitis or neuropathy" (VN) have a vestibular lesion pattern consistent with the distribution of the neurological afferents. BACKGROUND: Much is known about the clinical nature of PVP, however less so about its etiology and pathogenesis. Due to the frequency with which VN is used to describe the syndrome, an inflammation of the vestibular nerve or of one of its branches is often assumed to be the cause of PVP, though there is insufficient data so far to support this assumption...
July 2, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27379548/management-of-sudden-sensorineural-hearing-loss
#19
Aaron M Metrailer, Seilesh C Babu
PURPOSE OF REVIEW: Sudden sensorineural hearing loss (SNHL) is an otologic emergency and should be managed quickly and effectively. This review focuses on the management of sudden SNHL, primarily idiopathic sudden SNHL as it is the most common cause. RECENT FINDINGS: Management options include observation, oral steroids, intratympanic steroids, or combined oral/intratympanic steroids. One-third to two-thirds of patients will achieve spontaneous recovery, most likely within the first 2 weeks...
October 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27379547/primary-treatment-of-idiopathic-sudden-sensorineural-hearing-loss-with-intratympanic-dexamethasone
#20
Candace E Hobson, Thomas H Alexander, Jeffrey P Harris
PURPOSE OF REVIEW: Systemic corticosteroids have been the mainstay of treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) for over 30 years. Recently, intratympanic steroids have risen in popularity; however, there is no consensus regarding the details of their application. The purpose of this article is to review the current literature and share our opinion that intratympanic dexamethasone (alone or with systemic steroids) should be offered as primary treatment of ISSNHL...
October 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
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