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https://www.readbyqxmd.com/read/28651252/combined-diffusion-tensor-and-magnetic-resonance-spectroscopic-imaging-methodology-for-automated-regional-brain-analysis-application-in-a-normal-pediatric-population
#1
Nirmalya Ghosh, Barbara Holshouser, Udo Oyoyo, Stanley Barnes, Karen Tong, Stephen Ashwal
During human brain development, anatomic regions mature at different rates. Quantitative anatomy-specific analysis of longitudinal diffusion tensor imaging (DTI) and magnetic resonance spectroscopic imaging (MRSI) data may improve our ability to quantify and categorize these maturational changes. Computational tools designed to quickly fuse and analyze imaging information from multiple, technically different datasets would facilitate research on changes during normal brain maturation and for comparison to disease states...
June 27, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28649677/outcome-prediction-for-patient-with-high-grade-gliomas-from-brain-functional-and-structural-networks
#2
Luyan Liu, Han Zhang, Islem Rekik, Xiaobo Chen, Qian Wang, Dinggang Shen
High-grade glioma (HGG) is a lethal cancer, which is characterized by very poor prognosis. To help optimize treatment strategy, accurate preoperative prediction of HGG patient's outcome (i.e., survival time) is of great clinical value. However, there are huge individual variability of HGG, which produces a large variation in survival time, thus making prognostic prediction more challenging. Previous brain imaging-based outcome prediction studies relied only on the imaging intensity inside or slightly around the tumor, while ignoring any information that is located far away from the lesion (i...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28648753/association-of-increased-genotypes-risk-for-bipolar-disorder-with-brain-white-matter-integrity-investigated-with-tract-based-spatial-statistics
#3
REVIEW
L Squarcina, J Houenou, A C Altamura, J Soares, P Brambilla
BACKGROUND: Diffusion tensor imaging (DTI) studies, which allow the in-vivo investigation of brain tissue integrity, have shown that bipolar disorder (BD) patients present signs of white matter dysconnectivity. In parallel, genome-wide association studies (GWAS) identified several risk genetic variants for BD. I METHODS: In this mini-review, we summarized DTI studies coupling tract-based spatial statistics (TBSS), a reliable technique exploring white matter axon bundles, and genetics in BD...
June 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28648470/drug-target-interaction-prediction-by-integrating-multiview-network-data
#4
Xin Zhang, Limin Li, Michael K Ng, Shuqin Zhang
Drug-target interaction (DTI) prediction is a challenging step in further drug repositioning, drug discovery and drug design. The advent of high-throughput technologies brings convenience to the development of DTI prediction methods. With the generation of a high number of data sets, many mathematical models and computational algorithms have been developed to identify the potential drug-target pairs. However, most existing methods are proposed based on the single view data. By integrating the drug and target data from different views, we aim to get more stable and accurate prediction results...
March 31, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28648111/reduction-of-white-matter-integrity-correlates-with-apathy-in-parkinson-s-disease
#5
Yang Zhang, Jiayong Wu, Wenbo Wu, Renyuan Liu, Lingen Pang, Dening Guan, Yun Xu
BACKGROUND: Apathy is a common non-movement symptom in Parkinson's disease (PD), but little is known about apathy and white matter (WM) change. In this study, we investigated whether fractional anisotropy (FA) of the WM can distinguish apathetic patients from non-apathetic PD patients, and whether FA value correlates with the severity of apathy in PD. METHODS: Thirty nine PD patients were participated in our study, of which 18 participants with apathy symptom, and 21 without apathy symptom...
June 26, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28647657/distribution-and-network-of-basal-temporal-language-areas-a-study-of-the-combination-of-electric-cortical-stimulation-and-diffusion-tensor-imaging
#6
Rei Enatsu, Aya Kanno, Satoshi Ookawa, Satoko Ochi, Sumio Ishiai, Takashi Nagamine, Nobuhiro Mikuni
OBJECTIVE: The basal temporal language area (BTLA) is considered to have several functions in language processing; however, its brain network is still unknown. This study investigated the distribution and networks of the BTLA using a combination of electric cortical stimulation and diffusion tensor imaging (DTI). METHOD: Ten patients with intractable focal epilepsy who underwent presurgical evaluation with subdural electrodes were enrolled in this study (language dominant side: six patients, language non-dominant side: four patients)...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28645590/endoscopic-supracerebellar-transtentorial-approach-to-the-atrium-of-the-lateral-ventricle-preliminary-surgical-and-optical-considerations
#7
Tao Xie, Linjun Zhou, Xiaobiao Zhang, Wei Sun, Hailin Ding, Tengfei Liu, Ye Gu, Chongjing Sun, Fan Hu, Wei Zhu
OBJECTIVE: To report the operative techniques of the endoscopic supracerebellar transtentorial approach (ESTA) to the atrium of the lateral ventricle, especially focusing on the role of the endoscope and analyzing optically related issues. METHODS: A retrospective data review was performed on five patients with lesions in the atrium of the lateral ventricle undergoing the ESTA. The patients were positioned in the three-quarters prone position, and a paramidline linear incision was used...
June 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28644999/diffusion-tensor-imaging-of-cingulum-bundle-and-corpus-callosum-in-schizophrenia-vs-bipolar-disorder
#8
Igor Nenadić, Anna Hoof, Maren Dietzek, Kerstin Langbein, Jürgen R Reichenbach, Heinrich Sauer, Daniel Güllmar
Both schizophrenia and bipolar disorder show abnormalities of white matter, as seen in diffusion tensor imaging (DTI) analyses of major brain fibre bundles. While studies in each of the two conditions have indicated possible overlap in anatomical location, there are few direct comparisons between the disorders. Also, it is unclear whether phenotypically similar subgroups (e.g. patients with bipolar disorder and psychotic features) might share white matter pathologies or be rather similar. Using region-of-interest (ROI) analysis of white matter with diffusion tensor imaging (DTI) at 3 T, we analysed fractional anisotropy (FA), radial diffusivity (RD), and apparent diffusion coefficient (ADC) of the corpus callosum and cingulum bundle in 33 schizophrenia patients, 17 euthymic (previously psychotic) bipolar disorder patients, and 36 healthy controls...
May 25, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28644998/olfactory-identification-deficit-predicts-white-matter-tract-impairment-in-alzheimer-s-disease
#9
Matthew R Woodward, Michael G Dwyer, Niels Bergsland, Jesper Hagemeier, Robert Zivadinov, Ralph Hb Benedict, Kinga Szigeti
Olfactory identification deficit (OID) has been associated with both aging and Alzheimer's disease (AD). In the context of an amnestic disorders, OID predicts conversion to AD. Neuroanatomical correlates could increase specificity and sensitivity and elucidate the mechanistic differences between OID in AD and aging. Cross-sectional analysis of white matter microstructural changes was performed using diffusion tensor imaging (DTI) and tract-based-spatial-statistics in amnestic mild cognitive impairment (aMCI), AD and normal controls (NC) in 66 subjects (26 AD, 15 aMCI, 25 NC)...
June 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28643955/diffusion-tensor-imaging-of-normal-appearing-white-matter-in-patients-with-neuromyelitis-optica-spectrum-disorder-and-multiple-sclerosis
#10
S-H Kim, K Kwak, J-W Hyun, A Joung, S H Lee, Y-H Choi, J-M Lee, H J Kim
BACKGROUND AND PURPOSE: The occult changes in normal-appearing white matter (NAWM) were investigated and compared amongst patients with neuromyelitis optica spectrum disorder (NMOSD), patients with multiple sclerosis (MS) and healthy controls (HCs) by applying tract-based spatial statistics to diffusion tensor imaging (DTI) data. METHODS: Diffusion tensor imaging was performed with a 3-T scanner in 93 patients with NMOSD, 53 patients with MS and 43 HCs. Voxel-wise statistical analyses of the DTI data were performed using tract-based spatial statistics...
July 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28642175/subventricular-zone-involvement-characterised-by-dti-in-glioblastoma
#11
Bart Rj van Dijken, Jiun-Lin Yan, Natalie R Boonzaier, Chao Li, Peter Jan van Laar, Anouk van der Hoorn, Stephen J Price
BACKGROUND: Glioblastomas have a poor prognosis, possibly due to a subpopulation of therapy resistant stem cells within the heterogeneous glioblastoma. As the subventricular zone is the main source of neural stem cells, we aimed at characterising the subventricular zone using DTI to demonstrate subventricular zone involvement in glioblastoma. METHODS: We prospectively included 93 patients with primary glioblastomas who underwent preoperative DTI. The non-enhancing high FLAIR signal was used to describe the infiltrative tumour margin...
June 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28634624/population-averaged-macaque-brain-atlas-with-high-resolution-ex-vivo-dti-integrated-into-in-vivo-space
#12
Lei Feng, Tina Jeon, Qiaowen Yu, Minhui Ouyang, Qinmu Peng, Virendra Mishra, Mihovil Pletikos, Nenad Sestan, Michael I Miller, Susumu Mori, Steven Hsiao, Shuwei Liu, Hao Huang
Animal models of the rhesus macaque (Macaca mulatta), the most widely used nonhuman primate, have been irreplaceable in neurobiological studies. However, a population-averaged macaque brain diffusion tensor imaging (DTI) atlas, including comprehensive gray and white matter labeling as well as bony and facial landmarks guiding invasive experimental procedures, is not available. The macaque white matter tract pathways and microstructures have been rarely recorded. Here, we established a population-averaged macaque brain atlas with high-resolution ex vivo DTI integrated into in vivo space incorporating bony and facial landmarks, and delineated microstructures and three-dimensional pathways of major white matter tracts in vivo MRI/DTI and ex vivo (postmortem) DTI of ten rhesus macaque brains were acquired...
June 20, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28633499/lateralized-basal-ganglia-vulnerability-to-pesticide-exposure-in-asymptomatic-agricultural-workers
#13
Mechelle M Lewis, Nicholas W Sterling, Guangwei Du, Eun-Young Lee, Grace Shyu, Michael Goldenberg, Thomas Allen, Christy Stetter, Lan Kong, Shedra Amy Snipes, Byron C Jones, Honglei Chen, Richard B Mailman, Xuemei Huang
Background: Pesticide exposure is linked to Parkinson's disease (PD), a neurodegenerative disorder marked by dopamine cell loss in the substantia nigra of the basal ganglia (BG) that often presents asymmetrically. We previously reported that pesticide-exposed agricultural workers (AW) have nigral diffusion tensor (DTI) changes. The current study sought to confirm this finding, and explore its hemisphere and regional specificity within BG structures using an independent sample population...
June 19, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28631276/comparison-of-two-different-analysis-approaches-for-dti-free-water-corrected-and-uncorrected-maps-in-the-study-of-white-matter-microstructural-integrity-in-individuals-with-depression
#14
Maurizio Bergamino, Rayus Kuplicki, Teresa V Victor, Yoon-Hee Cha, Martin P Paulus
Diffusion tensor imaging (DTI) has often been used to examine white matter (WM) tract abnormalities in depressed subjects, but these studies have yielded inconsistent results, probably, due to gender composition or small sample size. In this study, we applied different analysis pipelines to a relatively large sample of individuals with depression to determine whether previous findings in depression can be replicated with these pipelines. We used a "standard" DTI algorithm and maps computed through a free-water (FW) corrected DTI...
June 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28630442/ir-sensitivity-enhancement-of-cmos-image-sensor-with-diffractive-light-trapping-pixels
#15
Sozo Yokogawa, Itaru Oshiyama, Harumi Ikeda, Yoshiki Ebiko, Tomoyuki Hirano, Suguru Saito, Takashi Oinoue, Yoshiya Hagimoto, Hayato Iwamoto
We report on the IR sensitivity enhancement of back-illuminated CMOS Image Sensor (BI-CIS) with 2-dimensional diffractive inverted pyramid array structure (IPA) on crystalline silicon (c-Si) and deep trench isolation (DTI). FDTD simulations of semi-infinite thick c-Si having 2D IPAs on its surface whose pitches over 400 nm shows more than 30% improvement of light absorption at λ = 850 nm and the maximum enhancement of 43% with the 540 nm pitch at the wavelength is confirmed. A prototype BI-CIS sample with pixel size of 1...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629742/statistical-differences-in-the-white-matter-tracts-in-subjects-with-depression-by-using-different-skeletonized-voxel-wise-analysis-approaches-and-dti-fitting-procedures
#16
Maurizio Bergamino, Madison Farmer, Hung-Wen Yeh, Elisabeth Paul, J Paul Hamilton
Major depressive disorder (MDD) is one of the most significant contributors to the global burden of illness. Diffusion tensor imaging (DTI) is a procedure that has been used in several studies to characterize abnormalities in white matter (WM) microstructural integrity in MDD. These studies, however, have provided divergent findings, potentially due to the large variety of methodological alternatives available in conducting DTI research. In order to determine the importance of different approaches to coregistration of DTI-derived metrics to a standard space, we compared results from two different skeletonized voxel-wise analysis approaches: the standard TBBS pipeline and the Advanced Normalization Tools (ANTs) approach incorporating a symmetric image normalization (SyN) algorithm and a group-wise template (ANTs TBSS)...
June 16, 2017: Brain Research
https://www.readbyqxmd.com/read/28628762/white-matter-microstructure-in-boys-with-persistent-depressive-disorder
#17
Veronika Vilgis, Alasdair Vance, Ross Cunnington, Timothy J Silk
BACKGROUND: Persistent depressive symptoms in children and adolescents are considered a risk factor for the development of major depressive disorder (MDD) later in life. Previous research has shown alterations in white matter microstructure in pediatric MDD but discrepancies exist as to the specific tracts affected. The current study aimed to improve upon previous methodology and address the question whether previous findings of lower fractional anisotropy (FA) replicate in a sample of children with persistent depressive disorder characterized by mild but more chronic symptoms of depression...
June 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28627942/diffusion-imaging-of-mild-traumatic-brain-injury-in-the-impact-accelerated-rodent-model-a-pilot-study
#18
Zora Kikinis, Marc Muehlmann, Ofer Pasternak, Sharon Peled, Praveen Kulkarni, Craig Ferris, Sylvain Bouix, Yogesh Rathi, Inga K Koerte, Steve Pieper, Alexander Yarmarkovich, Caryn L Porter, Bruce S Kristal, Martha E Shenton
PRIMARY OBJECTIVE: There is a need to understand pathologic processes of the brain following mild traumatic brain injury (mTBI). Previous studies report axonal injury and oedema in the first week after injury in a rodent model. This study aims to investigate the processes occurring 1 week after injury at the time of regeneration and degeneration using diffusion tensor imaging (DTI) in the impact acceleration rat mTBI model. RESEARCH DESIGN: Eighteen rats were subjected to impact acceleration injury, and three rats served as sham controls...
June 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28624562/impact-of-gradient-number-and-voxel-size-on-dti-tractography-for-resective-brain-surgery
#19
Friso W A Hoefnagels, Philip C de Witt Hamer, Petra J W Pouwels, Frederik Barkhof, W Peter Vandertop
OBJECTIVE: To explore quantitatively and qualitatively how the number of gradient directions (NGD) and spatial resolution (SR) affect DTI-tractography in patients planned for brain tumor surgery, using routine clinical MR-imaging protocols. METHODS: Of 67 patients with intracerebral lesions who had two different DTI-scans, three DTI-series were reconstructed to compare the effects of NGD and SR. Tractographies for four clinically relevant tracts (corticospinal tract, superior longitudinal fasciculus, optic radiation and inferior fronto-occipital fasciculus) were constructed with a probabilistic tracking algorithm and automated ROI-placement and compared for three quantitative measurements: tract volume, median fiber density and mean FA, using linear mixed-effects models...
June 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28623837/abnormal-asymmetry-in-benign-epilepsy-with-unilateral-and-bilateral-centrotemporal-spikes-a-combined-fmri-and-dti-study
#20
Weifang Cao, Yaodan Zhang, Changyue Hou, Fei Yang, Jinnan Gong, Sisi Jiang, Yue Huang, Ruhui Xiao, Cheng Luo, Xiaoming Wang, Dezhong Yao
Benign epilepsy with centrotemporal spikes (BECTS) is the most common idiopathic focal childhood epilepsy associated with either unilateral or bilateral epileptic discharge. Asymmetry as an important characteristic of the human brain is beneficial for brain functions. However, little is known about on asymmetry of BECTS patients with different epileptic spikes pattern. In the present study, we investigated functional and structural asymmetries in unilateral spikes BECTS (U_BECTS) patients and bilateral spikes BECTS (B_BECTS) patients using resting state functional magnetic resonance images and diffusion tensor imaging...
June 8, 2017: Epilepsy Research
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