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https://www.readbyqxmd.com/read/29234600/prediction-of-cognitive-and-motor-development-in-preterm-children-using-exhaustive-feature-selection-and-cross-validation-of-near-term-white-matter-microstructure
#1
Kornél Schadl, Rachel Vassar, Katelyn Cahill-Rowley, Kristin W Yeom, David K Stevenson, Jessica Rose
Background: Advanced neuroimaging and computational methods offer opportunities for more accurate prognosis. We hypothesized that near-term regional white matter (WM) microstructure, assessed on diffusion tensor imaging (DTI), using exhaustive feature selection with cross-validation would predict neurodevelopment in preterm children. Methods: Near-term MRI and DTI obtained at 36.6 ± 1.8 weeks postmenstrual age in 66 very-low-birth-weight preterm neonates were assessed...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29230526/peripheral-nerve-diffusion-tensor-imaging-dti-normal-values-and-demographic-determinants-in-a-cohort-of-60-healthy-individuals
#2
Moritz Kronlage, Véronique Schwehr, Daniel Schwarz, Tim Godel, Lorenz Uhlmann, Sabine Heiland, Martin Bendszus, Philipp Bäumer
OBJECTIVE: To identify demographic determinants of peripheral nerve diffusion tensor imaging (DTI) and to establish normal values for fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD). METHODS: Sixty subjects were examined at 3 Tesla by single-shot DTI. FA, AD, RD, and MD were collected for the sciatic, tibial, median, ulnar, and radial nerve and were correlated with demographic variables. RESULTS: Mean FA of all nerves declined with increasing age (r = -0...
December 11, 2017: European Radiology
https://www.readbyqxmd.com/read/29229299/diffusion-mri-of-white-matter-microstructure-development-in-childhood-and-adolescence-methods-challenges-and-progress
#3
REVIEW
Christian K Tamnes, David R Roalf, Anne-Lise Goddings, Catherine Lebel
Diffusion magnetic resonance imaging (dMRI) continues to grow in popularity as a useful neuroimaging method to study brain development, and longitudinal studies that track the same individuals over time are emerging. Over the last decade, seminal work using dMRI has provided new insights into the development of brain white matter (WM) microstructure, connections and networks throughout childhood and adolescence. This review provides an introduction to dMRI, both diffusion tensor imaging (DTI) and other dMRI models, as well as common acquisition and analysis approaches...
December 7, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29228858/common-patterns-of-regional-brain-injury-detectable-by-dti-in-otherwise-normal-appearing-white-matter-in-patients-with-early-moderate-to-severe-traumatic-brain-injury
#4
Kristine O'Phelan, Chad Kuniyuki Otoshi, Thomas M Ernst, Linda Chang
Traumatic brain injury (TBI) alters the lives of millions of people every year. Although mortality rates have improved, due to better prehospital care and reduction of secondary injury in the critical care setting, improvements in functional outcomes after TBI have been difficult to achieve. Diffusion-tensor imaging (DTI) allows detailed measurement of microstructural damage in regional brain tissue after TBI, thus improving our understanding of the extent and severity of TBI. METHODS: Twenty subjects were recruited from a Neurological Intensive Care Unit, and compared to 18 healthy control subjects...
December 11, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29227798/histological-and-mri-markers-of-white-matter-damage-in-focal-epilepsy
#5
REVIEW
Francesco Deleo, Maria Thom, Luis Concha, Andrea Bernasconi, Boris C Bernhardt, Neda Bernasconi
Growing evidence highlights the importance of white matter in the pathogenesis of focal epilepsy. Ex vivo and post-mortem studies show pathological changes in epileptic patients in white matter myelination, axonal integrity, and cellular composition. Diffusion-weighted MRI and its analytical extensions, particularly diffusion tensor imaging (DTI), have been the most widely used technique to image the white matter in vivo for the last two decades, and have shown microstructural alterations in multiple tracts both in the vicinity and at distance from the epileptogenic focus...
November 23, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29227148/structural-abnormalities-and-altered-regional-brain-activity-in-multiple-sclerosis-with-simple-spinal-cord-involvement
#6
Ping Yin, Yi Liu, Hua Xiong, Yongliang Han, Shambhu Kumar Sah, Chun Zeng, Jingjie Wang, Yongmei Li
OBJECTIVE: To assess the changes of the structural and functional abnormalities in multiple sclerosis with simple spinal cord involvement (MS-SSCI) by using resting-state functional magnetic resonance imaging (RS-fMRI), voxel based morphology (VBM) and diffusion tensor tractography. METHODS: The amplitude of low-frequency fluctuation (ALFF) of 22 patients with MS-SSCI and 22 healthy controls (HCs) matched for age, gender and education were compared by using RS-fMRI...
December 11, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29226864/cardiorespiratory-fitness-and-white-matter-neuronal-fiber-integrity-in-mild-cognitive-impairment
#7
Kan Ding, Takashi Tarumi, David C Zhu, Benjamin Tseng, Binu P Thomas, Marcel Turner, Justin Repshas, Diana R Kerwin, Kyle B Womack, Hanzhang Lu, C Munro Cullum, Rong Zhang
BACKGROUND: Mounting evidence showed the self-reported levels of physical activity are positively associated with white matter (WM) integrity and cognitive performance in normal adults and patients with mild cognitive impairment (MCI). However, the objective measure of cardiorespiratory fitness (CRF) was not used in these studies. OBJECTIVE: To determine the associations of CRF measured by maximal oxygen uptake (VO2max) with WM fiber integrity and neurocognitive performance in older adults with MCI...
December 6, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29220866/neural-correlates-of-fatigue-in-multiple-sclerosis-a-combined-neurophysiological-and-neuroimaging-approach-r1
#8
M Russo, A Calamuneri, A Cacciola, L Bonanno, A Naro, V Dattola, E Sessa, M Buccafusca, D Milardi, P Bramanti, R S Calabrò, A Quartarone
The present study is aimed at further exploring structural and functional correlates of fatigue in Relapsing- Remitting Multiple Sclerosis (RRMS) patients by using a combined approach by means of transcranial magnetic stimulation (TMS) and a Diffusion Tensor Imaging (DTI). The physiopathology of fatigue in MS is still poorly understood, although a variety of pathogenic mechanisms has been proposed. Our working hypothesis is that diffuse microstructural white matter damage may subtend the cortico-subcortical functional disconnection described in patients with MS and fatigue...
September 30, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29218370/differentiation-of-residual-recurrent-gliomas-from-postradiation-necrosis-with-arterial-spin-labeling-and-diffusion-tensor-magnetic-resonance-imaging-derived-metrics
#9
Ahmed Abdel Khalek Abdel Razek, Lamiaa El-Serougy, Mohamed Abdelsalam, Gada Gaballa, Mona Talaat
PURPOSE: The aim of this study is to differentiate recurrent/residual gliomas from postradiation changes using arterial spin labeling (ASL) perfusion and diffusion tensor imaging (DTI)-derived metrics. METHODS: Prospective study was conducted upon 42 patients with high-grade gliomas after radiotherapy only or prior to other therapies that underwent routine MR imaging, ASL, and DTI. The tumor blood flow (TBF), fractional anisotropy (FA), and mean diffusivity (MD) of the enhanced lesion and related edema were calculated...
December 7, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29217256/lateral-medullary-syndrome-following-injury-of-the-vestibular-pathway-to-the-core-vestibular-cortex-diffusion-tensor-imaging-study
#10
Sang Seok Yeo, Sung Ho Jang, Jung Won Kwon
OBJECTIVE: The parieto-insular vestibular cortex (PIVC) is a core region of vestibular input into regions of the cortex. The vestibular nuclei have reciprocal connections with the PIVC. However, little is known about injury of the core vestibular pathway to the PIVC in patients with dorsolateral medullary infarctions. In this study, using diffusion tensor tractography (DTT), we investigated injury of the neural connections between the vestibular nuclei and the PIVC in patients with typical central vestibular disorder...
December 4, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29216635/deficits-in-docosahexaenoic-acid-accrual-during-adolescence-reduce-rat-forebrain-white-matter-microstructural-integrity-an-in-vivo-diffusion-tensor-imaging-study
#11
Robert K McNamara, Jennifer D Schurdak, Ruth H Asch, Bart D Peters, Diana M Lindquist
Neuropsychiatric disorders that frequently initially emerge during adolescence are associated with deficits in the omega-3 (n-3) fatty acid docosahexaenoic acid (DHA), elevated proinflammatory signaling, and regional reductions in white matter integrity (WMI). This study determined the effects of altering brain DHA accrual during adolescence on WMI in the rat brain by diffusion tensor imaging (DTI), and investigated the potential mediating role of proinflammatory signaling. During periadolescent development, male rats were fed a diet deficient in n-3 fatty acids (DEF, n = 20), a fish oil-fortified diet containing preformed DHA (FO, n = 20), or a control diet (CON, n = 20)...
December 8, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/29213008/the-relationship-between-neurite-density-measured-with-confocal-microscopy-in-a-cleared-mouse-brain-and-metrics-obtained-from-diffusion-tensor-and-diffusion-kurtosis-imaging
#12
Ryusuke Irie, Koji Kamagata, Aurelien Kerever, Ryo Ueda, Suguru Yokosawa, Yosuke Otake, Hisaaki Ochi, Hidekazu Yoshizawa, Ayato Hayashi, Kazuhiko Tagawa, Hitoshi Okazawa, Kohske Takahashi, Kanako Sato, Masaaki Hori, Eri Arikawa-Hirasawa, Shigeki Aoki
PURPOSE: Diffusional kurtosis imaging (DKI) enables sensitive measurement of tissue microstructure by quantifying the non-Gaussian diffusion of water. Although DKI is widely applied in many situations, histological correlation with DKI analysis is lacking. The purpose of this study was to determine the relationship between DKI metrics and neurite density measured using confocal microscopy of a cleared mouse brain. METHODS: One thy-1 yellow fluorescent protein 16 mouse was deeply anesthetized and perfusion fixation was performed...
December 7, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29212957/comparison-of-glass-capillary-plates-and-polyethylene-fiber-bundles-as-phantoms-to-assess-the-quality-of-diffusion-tensor-imaging
#13
Atsushi Tachibana, Yasuhiko Tachibana, Jeff Kershaw, Hiromi Sano, Masahiro Fukushi, Takayuki Obata
PURPOSE: The purpose of this study was to evaluate the suitability of two phantoms, one made of capillary plates and the other polyethylene fibers, for assessing the quality of diffusion tensor imaging (DTI). METHODS: The first phantom was a stack of glass capillary plates with many parallel micropores (CP). The second phantom was a bundle of polyethylene fiber Dyneema held together with a thermal shrinkage tube (Dy). High resolution multi-shot echo planar imaging (EPI) DTI acquisitions were performed at b-values of 0 and 1000 s/mm2 and diffusion-times (Tdiff) of 37...
December 5, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29212855/t-cell-densities-in-brain-metastases-are-associated-with-patient-survival-times-and-diffusion-tensor-mri-changes
#14
Rasheed Zakaria, Angela Platt-Higgins, Nitika Rathi, Mark Radon, Sumit Das, Kumar Das, Maneesh Bhojak, Andrew Brodbelt, Emmanuel Chavredakis, Michael D Jenkinson, Philip S Rudland
Brain metastases are common and are usually detected by magnetic resonance imaging (MRI). Diffusion tensor imaging (DTI) is a derivative MRI technique which can detect disruption of white matter tracts in the brain. We have matched preoperative DTI with image-guided sampling of the brain-tumor interface in 26 patients during resection of a brain metastasis and assessed mean diffusivity (MD) and fractional anisotropy (FA). The tissue samples were analysed for vascularity, inflammatory cell infiltration, growth pattern, and tumor expression of proteins associated with growth or local invasion such as Ki67, S100A4, and MMP2, 9, and 13...
December 6, 2017: Cancer Research
https://www.readbyqxmd.com/read/29211865/the-impact-of-diffusion-tensor-imaging-fiber-tracking-of-the-corticospinal-tract-based-on-navigated-transcranial-magnetic-stimulation-on-surgery-of-motor-eloquent-brain-lesions
#15
Giovanni Raffa, Alfredo Conti, Antonino Scibilia, Salvatore Massimiliano Cardali, Felice Esposito, Filippo Flavio Angileri, Domenico La Torre, Carmela Sindorio, Rosaria Viola Abbritti, Antonino Germanò, Francesco Tomasello
BACKGROUND: Navigated transcranial magnetic stimulation (nTMS) enables preoperative mapping of the motor cortex (M1). The combination of nTMS with diffusion tensor imaging fiber tracking (DTI-FT) of the corticospinal tract (CST) has been described; however, its impact on surgery of motor-eloquent lesions has not been addressed. OBJECTIVE: To analyze the impact of nTMS-based mapping on surgery of motor-eloquent lesions. METHODS: In this retrospective case-control study, we reviewed the data of patients operated for suspected motor-eloquent lesions between 2012 and 2015...
November 29, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29211751/diffusion-tensor-imaging-detects-ventilation-induced-brain-injury-in-preterm-lambs
#16
Dhafer M Alahmari, Kyra Y Y Chan, Vanesa Stojanovska, Domenic LaRosa, Samantha K Barton, Ilias Nitsos, Valerie Zahra, Jade Barbuto, Michael Farrell, Shigeo Yamaoka, James T Pearson, Graeme R Polglase
PURPOSE: Injurious mechanical ventilation causes white matter (WM) injury in preterm infants through inflammatory and haemodynamic pathways. The relative contribution of each of these pathways is not known. We hypothesised that in vivo magnetic resonance imaging (MRI) can detect WM brain injury resulting from mechanical ventilation 24 h after preterm delivery. Further we hypothesised that the combination of inflammatory and haemodynamic pathways, induced by umbilical cord occlusion (UCO) increases brain injury at 24 h...
2017: PloS One
https://www.readbyqxmd.com/read/29209586/diffusion-tensor-imaging-and-tractography-application-in-pre-operative-planning-of-intra-axial-brain-lesions
#17
Neetu Soni, Anant Mehrotra, Sanjay Behari, Sunil Kumar, Nishant Gupta
Gliomas are the most common brain tumors that diffusely infiltrate the surrounding white matter (WM) tracts. Conventional MRI is commonly used for tumor localization and characterization. However, this does not give precise information about the WM infiltration surrounding the tumor. Diffusion-tensor imaging (DTI) is a non-invasive magnetic resonance (MR) technique that measures WM tissue integrity and tractography (fiber tracking) used to investigate the preferential directionality of diffusion. DTI allows visualization of WM tracts in the immediate vicinity of brain tumors that permit maximum tumor resection while also preserving the eloquent brain areas...
October 3, 2017: Curēus
https://www.readbyqxmd.com/read/29205635/cerebral-white-matter-maturation-patterns-in-preterm-infants-an-mri-t2-relaxation-anisotropy-and-diffusion-tensor-imaging-study
#18
Michael J Knight, Adam Smith-Collins, Sarah Newell, Mark Denbow, Risto A Kauppinen
BACKGROUND AND PURPOSE: Preterm birth is associated with worse neurodevelopmental outcome, but brain maturation in preterm infants is poorly characterized with standard methods. We evaluated white matter (WM) of infant brains at term-equivalent age, as a function of gestational age at birth, using multimodal magnetic resonance imaging (MRI). METHODS: Infants born very preterm (<32 weeks gestation) and late preterm (33-36 weeks gestation) were scanned at 3 T at term-equivalent age using diffusion tensor imaging (DTI) and T2 relaxometry...
December 5, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29204431/efficacy-of-ventilator-waveform-observation-for-detection-of-patient-ventilator-asynchrony-during-niv-a-multicentre-study
#19
Federico Longhini, Davide Colombo, Lara Pisani, Francesco Idone, Pan Chun, Jonne Doorduin, Liu Ling, Moreno Alemani, Andrea Bruni, Jin Zhaochen, Yu Tao, Weihua Lu, Eugenio Garofalo, Luca Carenzo, Salvatore Maurizio Maggiore, Haibo Qiu, Leo Heunks, Massimo Antonelli, Stefano Nava, Paolo Navalesi
The objective of this study was to assess ability to identify asynchronies during noninvasive ventilation (NIV) through ventilator waveforms according to experience and interface, and to ascertain the influence of breathing pattern and respiratory drive on sensitivity and prevalence of asynchronies. 35 expert and 35 nonexpert physicians evaluated 40 5-min NIV reports displaying flow-time and airway pressure-time tracings; identified asynchronies were compared with those ascertained by three examiners who evaluated the same reports displaying, additionally, tracings of diaphragm electrical activity...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29201580/multimodality-3d-superposition-and-automated-whole-brain-tractography-comprehensive-printing-of-the-functional-brain
#20
Sanjay Konakondla, Cameron J Brimley, Jesna Mathew Sublett, Edward Stefanowicz, Sarah Flora, Gino Mongelluzzo, Clemens M Schirmer
Whole brain tractography using diffusion tensor imaging (DTI) sequences can be used to map cerebral connectivity; however, this can be time-consuming due to the manual component of image manipulation required, calling for the need for a standardized, automated, and accurate fiber tracking protocol with automatic whole brain tractography (AWBT). Interpreting conventional two-dimensional (2D) images, such as computed tomography (CT) and magnetic resonance imaging (MRI), as an intraoperative three-dimensional (3D) environment is a difficult task with recognized inter-operator variability...
September 29, 2017: Curēus
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