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https://www.readbyqxmd.com/read/29656270/reduced-integrity-of-the-uncinate-fasciculus-and-cingulum-in-depression-a-stem-by-stem-analysis
#1
Kartik D Bhatia, Luke A Henderson, Eugene Hsu, Mark Yim
INTRODUCTION: The subgenual cingulate gyrus (Brodmann's Area 25: BA25) is hypermetabolic in depression and has been targeted successfully with deep brain stimulation. Two of the white matter tracts that play a role in treatment response are the uncinate fasciculus (UF) and the cingulum bundle. The UF has three prefrontal stems, the most medial of which extends from BA25 (which deals with mood regulation) and the most lateral of which extends from the dorso-lateral prefrontal cortex (concerned with executive function)...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29653337/investigation-of-microstructural-abnormalities-in-white-and-gray-matter-around-hippocampus-with-diffusion-tensor-imaging-dti-in-temporal-lobe-epilepsy-tle
#2
Yixin Bao, Ruqian He, Qingyi Zeng, Pan Zhu, Rongyuan Zheng, Huiqin Xu
OBJECTIVE: The objective of this study was to apply diffusion tensor imaging (DTI) to investigate microstructural abnormalities in temporal lobe epilepsy (TLE) with and without hippocampal sclerosis (HS). MATERIALS: Totally, 19 patients with TLE with HS and 23 patients with TLE without HS were included. Fiber tracking fibers focused on the parahippocampal cingulum (PHC), cingulate gyrus (CG), and fornix (FORX). Fractional anisotropy (FA) and mean diffusivity (MD) values were obtained, and hippocampal volumes were measured...
April 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29652228/prediction-of-clinical-outcome-in-subacute-subarachnoid-hemorrhage-using-diffusion-tensor-imaging
#3
Isabel Fragata, Marta Alves, Ana Luísa Papoila, Patrícia Ferreira, Ana Paiva Nunes, Nuno Canto Moreira, Patrícia Canhão
OBJECTIVE Clinical outcome in nontraumatic subarachnoid hemorrhage (SAH) is multifactorial and difficult to predict. Diffusion tensor imaging (DTI) findings are a prognostic marker in some diseases such as traumatic brain injury. The authors hypothesized that DTI parameters measured in the subacute phase of SAH can be associated with a poor clinical outcome. METHODS Diffusion tensor imaging was prospectively performed in 54 patients at 8-10 days after nontraumatic SAH. Logistic regression analysis was performed to evaluate the association of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values with a poor clinical outcome (modified Rankin Scale score ≥ 3) at 3 months...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29651768/minimisation-of-signal-intensity-differences-in-distortion-correction-approaches-of-brain-magnetic-resonance-diffusion-tensor-imaging
#4
Dong-Hoon Lee, Do-Wan Lee, David Henry, Hae-Jin Park, Bong-Soo Han, Dong-Cheol Woo
OBJECTIVES: To evaluate the effects of signal intensity differences between the b0 image and diffusion tensor imaging (DTI) in the image registration process. METHODS: To correct signal intensity differences between the b0 image and DTI data, a simple image intensity compensation (SIMIC) method, which is a b0 image re-calculation process from DTI data, was applied before the image registration. The re-calculated b0 image (b0ext ) from each diffusion direction was registered to the b0 image acquired through the MR scanning (b0nd ) with two types of cost functions and their transformation matrices were acquired...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29649574/detection-of-high-gs-risk-group-prostate-tumors-by-diffusion-tensor-imaging-and-logistic-regression-modelling
#5
Gokhan Ertas
PURPOSE: To assess the value of joint evaluation of diffusion tensor imaging (DTI) measures by using logistic regression modelling to detect high GS risk group prostate tumors. MATERIALS AND METHODS: Fifty tumors imaged using DTI on a 3 T MRI device were analyzed. Regions of interests focusing on the center of tumor foci and noncancerous tissue on the maps of mean diffusivity (MD) and fractional anisotropy (FA) were used to extract the minimum, the maximum and the mean measures...
April 9, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29649488/proteomics-based-identification-of-differential-plasma-proteins-and-changes-in-white-matter-integrity-as-markers-in-early-detection-of-mild-cognitive-impaired-subjects-at-high-risk-of-alzheimer-s-disease
#6
Abhai Kumar, Smita Singh, Ashish Verma, Vijay Nath Mishra
Mild cognitive impairment (MCI) is an intermediate stage of cognitive decline and dementia. The absence of specific diagnostic test for identification of MCI and AD. The current study aims to find proteomics based change in plasma proteins and diffusion tensor imaging (DTI) based white matter changes in MCI for early detection of prodromal Alzheimer's disease. Fifty cases of mild cognitive impairment and age matched control between (55-75 yrs) were screened on basis of Mini Mental State Examination (MMSE). Two dimensional gel electrophoresis and DTI imaging was performed in MCI and age matched control...
April 9, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29648462/a-systematic-review-of-neuroimaging-findings-in-children-and-adolescents-with-sports-related-concussion
#7
Emilie Chamard, Jonathan D Lichtenstein
BACKGROUND: Sport-related concussion (SRC) generally does not result in structural anomalies revealed through clinical imaging techniques such as MRI and CT. While advanced neuroimaging techniques offer another avenue to investigate the subtle alterations following SRC, the current pediatric literature in this area has yet to be reviewed. The aim of this review is to systematically explore the literature on magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), functional magnetic resonance imaging (fMRI), and cortical thickness following SRC in children and adolescents...
April 12, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29643448/shorter-sleep-duration-and-better-sleep-quality-are-associated-with-greater-tissue-density-in-the-brain
#8
Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima
Poor sleep quality is associated with unfavorable psychological measurements, whereas sleep duration has complex relationships with such measurements. The aim of this study was to identify the associations between microstructural properties of the brain and sleep duration/sleep quality in a young adult. The associations between mean diffusivity (MD), a measure of diffusion tensor imaging (DTI), and sleep duration/sleep quality were investigated in a study cohort of 1201 normal young adults. Positive correlations between sleep duration and MD of widespread areas of the brain, including the prefrontal cortex (PFC) and the dopaminergic systems, were identified...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29629942/paediatric-multiple-sclerosis-and-other-acute-demyelinating-diseases
#9
Kevin Rostásy, Barbara Bajer-Kornek
PURPOSE OF REVIEW: Neuroimmunological diseases encompass a wide spectrum of diseases in children. Apart from the discovery of autoantibodies affecting primarily grey matter structures and the improved clinical characterization of rare entities such as N-methyl D-aspartate receptor-R- encephalitis, important strides have also been made in autoimmune-mediated white matter diseases, including paediatric multiple sclerosis (pedMS) and other acute demyelinating syndromes (ADS) often associated with antibodies (abs) against myelin-oligodendrocyte-glycoprotein (MOG)...
April 7, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29629498/multifocal-alterations-of-white-matter-accompany-the-transition-from-normal-cognition-to-dementia-in-parkinson-s-disease-patients
#10
Maria Chondrogiorgi, Loukas G Astrakas, Anastasia K Zikou, Luca Weis, Vassilios G Xydis, Angelo Antonini, Maria I Argyropoulou, Spiridon Konitsiotis
The purpose of the present study was to investigate the pattern of white matter (WM) changes associated with Parkinson's disease (PD)-related cognitive impairment by using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) measures. Diffusion Tensor Imaging (DTI) was performed in 21 PD-patients with dementia (PDD) and in an age-matched control group including 40 PD-patients without dementia (PD-CTRL). The Parkinson's disease-Cognitive Rating Scale (PD-CRS) was used for patients' neuropsychological assessment...
April 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29627940/effects-of-motor-rehabilitation-on-mobility-and-brain-plasticity-in-multiple-sclerosis-a-structural-and-functional-mri-study
#11
Eleonora Tavazzi, Niels Bergsland, Davide Cattaneo, Elisa Gervasoni, Maria Marcella Laganà, Ottavia Dipasquale, Cristina Grosso, Francesca Lea Saibene, Francesca Baglio, Marco Rovaris
BACKGROUND: Rehabilitation seems to promote brain plasticity, but objective measures of efficacy are lacking and there is a limited understanding of the mechanisms underlying functional recovery. OBJECTIVE: To study functional and structural brain changes induced by gait rehabilitation. METHODS: We enrolled MS inpatients (EDSS 4.5-6.5) undergoing a 4-week neurorehabilitation. Several clinical measures were obtained, including: 2-min walk test (2MWT), dynamic gait index (DGI), Berg balance scale (BBS)...
April 7, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29627590/exploring-experimental-autoimmune-optic-neuritis-using-multimodal-imaging
#12
Praveena Manogaran, Christine Walker-Egger, Marijana Samardzija, Conny Waschkies, Christian Grimm, Markus Rudin, Sven Schippling
BACKGROUND: Neuro-axonal injury is a key contributor to non-reversible long-term disability in multiple sclerosis (MS). However, the underlying mechanisms are not yet fully understood. Visual impairment is common among MS patients, in which episodes of optic neuritis (ON) are often followed by structural retinal damage and sustained functional impairment. Alterations in the optic nerve and retina have also been described in rodent experimental autoimmune encephalomyelitis (EAE), a model of MS...
April 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29627017/effect-of-teriflunomide-on-gray-and-white-matter-brain-pathology-in-multiple-sclerosis-using-volumetric-and-diffusion-tensor-imaging-mri-measures
#13
Robert Zivadinov, Niels Bergsland, Jesper Hagemeier, Ellen Carl, Hanna Kolb, David Hojnacki, Bianca Weinstock-Guttman
OBJECTIVES: To investigate the effect of teriflunomide on microstructural pathology in the gray matter (GM) and white matter (WM), as measured by changes in brain volume and diffusion-tensor imaging (DTI) in patients with multiple sclerosis (MS). METHODS: 30 relapsing MS patients and 20 healthy controls (HCs) were enrolled in the study and followed prospectively for 12 months with clinical and 3T MRI examinations. Of those, 26 MS patients and 18 HCs completed the 6-month and 22 MS and 16 HCs patients the 12-month follow-up...
May 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29625454/white-matter-abnormalities-and-correlation-with-severity-in-normal-tension-glaucoma-a-whole-brain-atlas-based-diffusion-tensor-study
#14
Rong Wang, Zuohua Tang, Xinghuai Sun, Lingjie Wu, Jie Wang, Yufeng Zhong, Zebin Xiao
Purpose: To detect injury of whole brain white matter (WM) in normal tension glaucoma (NTG) patients by using diffusion tensor imaging (DTI) and to analyze the correlations between DTI parameters and glaucoma indices. Methods: Twenty mild, 17 moderate, and 18 severe NTG patients as well as 25 normal subjects were enrolled in this study. Atlas-based diffusion tensor analysis was performed to measure the fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD)...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29623945/optic-radiation-injury-in-patients-with-aneurismal-subarachnoid-hemorrhage-a-preliminary-diffusion-tensor-imaging-report
#15
Sung Ho Jang, Chul Hoon Chang, Young Jin Jung, Seong Ho Kim, Jeong Pyo Seo
Visual field defect is one of the various clinical manifestations in patients with subarachnoid hemorrhage (SAH). Little is known about the pathogenic mechanism of visual field defect in SAH. In the current study, we investigated the diffusion tensor imaging (DTI) finding of the optic radiation in patients with SAH following rupture of a cerebral artery aneurysm. We recruited 21 patients with aneurismal SAH (12 males, 9 females, mean age, 52.67 years; range, 41-68 years) who showed no definite lesion along the visual pathway...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29623940/dti-and-pathological-changes-in-a-rabbit-model-of-radiation-injury-to-the-spinal-cord-after-125-i-radioactive-seed-implantation
#16
Xia Cao, Le Fang, Chuan-Yu Cui, Shi Gao, Tian-Wei Wang
Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Radioactive125 I seeds to irradiate 90% of the spinal cord tissue at doses of 40-100 Gy (D90) were implanted in rabbits at T10 to induce radiation injury, and we evaluated their safety for use in the spinal cord...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29622488/cerebral-autoregulation-and-conventional-and-diffusion-tensor-imaging-magnetic-resonance-imaging-in-neonatal-hypoxic-ischemic-encephalopathy
#17
Melisa Carrasco, Jamie Perin, Jacky M Jennings, Charlamaine Parkinson, Maureen M Gilmore, Raul Chavez-Valdez, An N Massaro, Raymond C Koehler, Frances J Northington, Aylin Tekes, Jennifer K Lee
BACKGROUND: Deviation of mean arterial blood pressure (MAP) from the range that optimizes cerebral autoregulatory vasoreactivity (optimal MAP) could increase neurological injury from hypoxic-ischemic encephalopathy (HIE). We tested whether a global magnetic resonance imaging (MRI) brain injury score and regional diffusion tensor imaging (DTI) are associated with optimal MAP in neonates with HIE. METHODS: Twenty-five neonates cooled for HIE were monitored with the hemoglobin volume index...
April 2, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29620625/decreased-functional-connectivity-and-structural-deficit-in-alertness-network-with-right-sided-temporal-lobe-epilepsy
#18
Yujun Gao, Jinou Zheng, Yaping Li, Danni Guo, Mingli Wang, Xiangxiang Cui, Wei Ye
Patients with temporal lobe epilepsy (TLE) often suffer from alertness alterations. However, specific regions connected with alertness remain controversial, and whether these regions have structural impairment is also elusive. This study aimed to investigate the characteristics and neural mechanisms underlying the functions and structures of alertness network in patients with right-sided temporal lobe epilepsy (rTLE) by performing the attentional network test (ANT), resting-state functional magnetic resonance imaging (R-SfMRI), and diffusion tensor imaging (DTI)...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29619562/a-preliminary-study-of-3-0-t-magnetic-resonance-diffusion-tensor-imaging-in-cervical-spondylotic-myelopathy
#19
Fulong Dong, Yuanyuan Wu, Peiwen Song, Yinfeng Qian, Ying Wang, Liyan Xu, Minmin Yin, Renjie Zhang, Hui Tao, Peng Ge, Chang Liu, Huaqing Zhang, Jinwen Zhu, Cailiang Shen, Yongqiang Yu
PURPOSE: To compare diffusion tensor imaging (DTI) parameters of the spinal cord between patients with cervical spondylotic myelopathy (CSM) and normal subjects, and investigate their significance in the clinical diagnosis, surgical planning and post-operative evaluation of CSM. METHODS: Routine sequence magnetic resonance imaging (MRI) and DTI scans were performed in 50 normal subjects and 60 cases of CSM with 3.0-T MR. DTI images, apparent diffusion coefficient (ADC) and fractional anisotropy (FA) colormaps corresponding to spinal cord cross-sections were obtained...
April 4, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29615873/alterations-of-white-matter-integrity-and-hippocampal-functional-connectivity-in-type-2-diabetes-without-mild-cognitive-impairment
#20
Qian Sun, Guan-Qun Chen, Xi-Bin Wang, Ying Yu, Yu-Chuan Hu, Lin-Feng Yan, Xin Zhang, Yang Yang, Jin Zhang, Bin Liu, Cong-Cong Wang, Yi Ma, Wen Wang, Ying Han, Guang-Bin Cui
Aims : To investigate the white matter (WM) integrity and hippocampal functional connectivity (FC) in type 2 diabetes mellitus (T2DM) patients without mild cognitive impairment (MCI) by using diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI), respectively. Methods : Twelve T2DM patients without MCI and 24 age, sex and education matched healthy controls (HC) were recruited. DTI and rs-fMRI data were subsequently acquired on a 3.0T MR scanner. Tract-based spatial statistics (TBSS) combining region of interests (ROIs) analysis was used to investigate the alterations of DTI metrics (fractional anisotropy (FA), mean diffusivity (MD), λ1 and λ23 ) and FC measurement was performed to calculate hippocampal FC with other brain regions...
2018: Frontiers in Neuroanatomy
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