Ilona Nln, Justine Shum, Yogita Ghodke-Puranik, Regine Tipon, Danielle Triese, Shreyasee Amin, Ashima Makol, Thomas Osborn, Vaidehi Chowdhary, Uma Thanarajasingam, Theresa L Wampler Muskardin, Vilija Oke, Iva Gunnarsson, Agneta Zickert, Maria I Zervou, Dimitrios T Boumpas, Elisabet Svenungsson, George N Goulielmos, Timothy B Niewold
BACKGROUND: Viral infection outcomes vary widely between individuals, ranging from mild symptoms to severe organ failure and death, and it is clear that host genetic factors play a role in this variability. Type I interferon (IFN) is a critical anti-viral cytokine, and we have previously noted differences in type I IFN levels between world populations. METHODS: In this study, we investigate the interrelationship between regional European genetic ancestry, type I IFN levels, and severe viral infection outcomes...
March 26, 2024: QJM: Monthly Journal of the Association of Physicians