keyword
https://read.qxmd.com/read/38537134/nk-cell-elicited-gasdermin-d-dependent-hepatocyte-pyroptosis-induces-neutrophil-extracellular-traps-that-facilitates-hbv-related-acute-on-chronic-liver-failure
#1
JOURNAL ARTICLE
Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhi-Yong Guo
BACKGROUND AIMS: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537007/independent-predictors-for-non-alcoholic-fatty-liver-disease-in-patients-with-treatment-na%C3%A3-ve-chronic-hepatitis-b
#2
JOURNAL ARTICLE
Gulsah Tuncer, Ceyda Geyiktepe-Guclu, Osman Faruk Bayramlar, Burcu Atasoy Bozan, Cigdem Yucel, Betul Copur, Kadir Gorkem Guclu, Mustafa Yıldırım, Gonul Sengöz, Filiz Pehlivanoglu
OBJECTIVE: There are limited data on non-alcoholic fatty liver disease in chronic hepatitis B virus infection. We aimed to determine the predictors for non-alcoholic fatty liver disease in patients with treatment-naïve chronic hepatitis B virus infection. METHODS: All consecutive treatment-naïve patients with chronic hepatitis B virus infection at the Haseki Training and Research Hospital between October 1, 2021, and September 31, 2022, were retrospectively enrolled...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38536633/the-significance-of-m6a-rna-methylation-regulators-in-diagnosis-and-subtype-classification-of-hbv-related-hepatocellular-carcinoma
#3
JOURNAL ARTICLE
Qijuan Zang, Yalin Ju, Siyi Liu, Shaobo Wu, Chengbin Zhu, Liangru Liu, Weicheng Xu, Yingli He
In recent years, abnormal m6A alteration in hepatocellular carcinoma (HCC) has been a focus on investigating the biological implications. In this study, our objective is to determine whether m6A modification contributes to the progression of HBV-related HCC. To achieve this, we employed a random forest model to screen top 8 characteristic m6A regulators from 19 candidate genes. Subsequently, we developed a nomogram model that utilizes these 8 characteristic m6A regulators to predict the prevalence of HBV-related HCC...
March 27, 2024: Human Cell
https://read.qxmd.com/read/38536619/acceptability-and-feasibility-of-the-plasma-separation-card-for-an-integrated-model-of-care-for-hbv-and-hcv-screening-among-people-attending-hiv-clinics-in-cameroon-and-uganda
#4
JOURNAL ARTICLE
Camila A Picchio, Aina Nicolàs, Ironne Valdèse Ayemfouo Fofou, Viola Kasone, Magellan Guewo-Fokeng, Claude T Tagny, Teddy Nanyonjo, Hellen Nansumba, Yves Nacel Kouongni, Rita Gaëlle Epse Sezawo Kamdjeu, Emmanuel Seremba, Charles Kouanfack, Isaac Ssewanyana, Richard Njouom, Ariadna Rando Segura, Francisco Rodríguez-Frías, Jean Claude Mbanya, Ponsiano Ocama, Jeffrey V Lazarus
BACKGROUND: Sub-Saharan African countries have a high burden of viral hepatitis and poor access to screening and care. The aim of this study was to evaluate the feasibility and acceptability of using the plasma separation card (PSC) for viral hepatitis B and C screening among people living with HIV (PLHIV) in Cameroon and Uganda. METHODS: This is a cross-sectional study carried out between 05/2021 and 03/2023 including 192 PLHIV in Cameroon (n = 104) and Uganda (n = 88)...
March 27, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38535037/hepatic-artery-delineation-on-ultrasound-volumes-comparing-b-flow-and-color-doppler-for-postoperative-monitoring-of-pediatric-liver-transplants
#5
JOURNAL ARTICLE
Elena Dammann, Leonhard Steinmeister, Michael Groth, Uta Herden, Lutz Fischer, Florian Brinkert, Jan Beime, Magdalini Tozakidou, Peter Bannas, Jochen Herrmann
(1) Background: Accurate hepatic artery (HA) depiction following pediatric liver transplantation (LT) is essential for graft surveillance but challenging on ultrasound (US). This study assesses if improved HA delineation can be achieved by recording two-dimensional US volumes in Color Doppler (CD) and B-flow technique. (2) Methods: Of 42 consecutive LT, 37 cases were included, and HA delineation was retrospectively rated using a four-point score (0 = HA not detectable, 3 = HA fully detectable, separable from portal vein) within 48 h post-LT (U1) and before discharge (U2)...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38535025/comparison-of-transient-elastography-and-point-shear-wave-elastography-for-analysis-of-liver-stiffness-a-prospective-study
#6
JOURNAL ARTICLE
Giuseppe Losurdo, Ilaria Ditonno, Domenico Novielli, Francesca Celiberto, Andrea Iannone, Antonino Castellaneta, Paola Dell'Aquila, Nunzio Ranaldo, Maria Rendina, Michele Barone, Enzo Ierardi, Alfredo Di Leo
Liver stiffness measurement (LSM) by Fibroscan is the most used non-invasive method to assess liver fibrosis. Recently, point-shear wave elastography (pSWE) has been introduced as a simple alternative non-invasive test. Therefore, we aimed to compare the results of these two techniques. One hundred and eighty-four consecutive patients attending our outpatient ultrasound clinic were recruited. LSM was performed by both Fibroscan and pSWE. Statistical analysis was conducted by Spearman's test for correlation and linear regression...
March 12, 2024: Diagnostics
https://read.qxmd.com/read/38534974/protective-effects-of-propolis-and-chitosan-nanoparticles-against-ibuprofen-induced-hepatotoxicity-in-albino-rats
#7
JOURNAL ARTICLE
Fajer M AlKandari, Hussein S Mohamed, Sayed A Ahmed, Basant Mahmoud, Asmaa M Mahmoud
Post-marketing hepatotoxicity findings are more common or occur much later. NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen are consumed in large quantities around the world. NSAIDs have a low incidence of hepatotoxicity but their wide use makes them a major contributor to drug-induced liver injury. Hepatitis is linked to systemic oxidative stress which results in cellular necrosis and fibrosis, as well as tissue lipoprotein peroxidation and glutathione depletion. Given the lack of safe and effective anti-hepatitis drugs in medicine today, natural substances appear to be a promising and safe alternative...
February 29, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534881/primary-bone-lymphoma-of-the-scapula
#8
Josip Lovaković, Inga Mandac Smoljanović, Andro Matković, Tomislav Smoljanović
Primary bone lymphoma of the scapula is a rare tumor that usually causes local pain. The presented patient suffered for two years from paresthesia, tingling, numbness, and edema of the little and ring fingers. The 45-year-old man underwent several radiological and neurological assessments of the palm, elbow, and neck before radiographs revealed a tumor of the left shoulder. Once diffuse large B-cell lymphoma was confirmed, immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and methylprednisolone (R-CHOP) started...
February 28, 2024: Hematology Reports
https://read.qxmd.com/read/38534501/improving-generalizability-of-pet-dl-algorithms-list-mode-reconstructions-improve-dotatate-pet-hepatic-lesion-detection-performance
#9
JOURNAL ARTICLE
Xinyi Yang, Michael Silosky, Jonathan Wehrend, Daniel V Litwiller, Muthiah Nachiappan, Scott D Metzler, Debashis Ghosh, Fuyong Xing, Bennett B Chin
Deep learning (DL) algorithms used for DOTATATE PET lesion detection typically require large, well-annotated training datasets. These are difficult to obtain due to low incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and the high cost of manual annotation. Furthermore, networks trained and tested with data acquired from site specific PET/CT instrumentation, acquisition and processing protocols have reduced performance when tested with offsite data. This lack of generalizability requires even larger, more diverse training datasets...
February 27, 2024: Bioengineering
https://read.qxmd.com/read/38533812/copper-cu-metabolism-in-domestic-herbivores-as-guide-to-criteria-for-predicting-the-cu-nutritional-status-of-wild-ruminants-in-southern-africa
#10
JOURNAL ARTICLE
J B J van Ryssen, G F Bath
In southern Africa game farming has become an effective way of using underutilised resources and a valuable method of preserving and increasing wildlife numbers. However, little is known about the mineral requirements of wild animal species or the assessment of the mineral nutritional status of these species. To establish criteria for estimating the copper (Cu) nutritional status of wildlife, current knowledge about Cu metabolism and criteria for domestic animals has been used. Since the Cu metabolism of ruminants differs substantially from that of non-ruminants, Cu metabolism in domestic species such as cattle and sheep representing wild ruminants, and pigs and horses as non-ruminant species, has been scrutinised to propose criteria for wild bovids in southern Africa...
March 26, 2024: Journal of the South African Veterinary Association
https://read.qxmd.com/read/38533651/toward-a-functional-cure-for-hepatitis-b
#11
REVIEW
Anna S F Lok
Current treatment of chronic hepatitis B virus (HBV) infection, pegylated interferon-α (pegIFN-α) and nucleos(t)ide analogue (NA), can suppress HBV replication, reverse liver inflammation and fibrosis, and decrease risks of cirrhosis and hepatocellular carcinoma, but hepatitis B surface antigen (HBsAg) loss is rare. Functional HBV cure is defined as undetectable HBsAg and unquantifiable serum HBV DNA for at least 24 weeks after a finite course of therapy. This requires suppression of HBV replication and viral protein production as well as restoration of immune response to HBV...
March 27, 2024: Gut and Liver
https://read.qxmd.com/read/38533303/advances-and-challenges-in-managing-hepatitis-d-virus-evolving-strategies
#12
JOURNAL ARTICLE
Harish Gopalakrishna, Maria Mironova, Harel Dahari, Christopher Koh, Theo Heller
PURPOSE OF REVIEW: Hepatitis D Virus (HDV), although a small defective virus, poses a substantial public health challenge due to lack of awareness, underrecognized prevalence, and limited treatment options. Universal HDV screening within hepatitis B virus (HBV) cohorts is essential to address this issue. Despite its aggressive nature, effective HDV therapies have remained elusive for over four decades. RECENT FINDINGS: Advances in understanding HDV's biology and clinical behavior offer potential therapeutic breakthroughs, fostering optimism...
2024: Current Hepatology Reports
https://read.qxmd.com/read/38532918/analysis-of-risk-factor-for-pneumonia-in-children-less-than-five-years-in-makassar
#13
JOURNAL ARTICLE
Evalina Sidabutar, Ansariadi, Wahiduddin, Nadjib Bustan, Stang, Agus Bintara Birawida
BACKGROUND: Pneumonia is one of the main causes of mortality in children less than five years worldwide and in Makassar City. The aim of this study was to investigate the risk factors for pneumonia in children less than five years in Makassar City. MATERIALS AND METHODS: A case-control study design was used in this research. A total of 210 children with consent from the parents were included in this study, which consisted of 70 children's cases, and the data of the control group were taken by the random sampling method...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38532310/patients-with-chronic-hepatitis-b-who-have-persistently-normal-alanine-aminotransferase-or-aged%C3%A2-%C3%A2-30%C3%A2-years-may-exhibit-significant-histologic-damage
#14
JOURNAL ARTICLE
Sufang Wei, Qiuli Xie, Guichan Liao, Hongjie Chen, Meixin Hu, Xiaoli Lin, Hong Li, Jie Peng
BACKGROUND: The timing of antiviral therapy for chronic hepatitis B (CHB) patients with normal alanine transaminase (ALT) or aged < 30 years is still undetermined. We aimed to elucidate the correlation between liver histology, age, and ALT level in CHB patients and analyze the histological characteristics of the liver among patients with persistently normal ALT or aged < 30 years. METHODS: A retrospective analysis was conducted on 697 treatment-naive CHB patients...
March 27, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38531803/analysis-and-investigation-of-bioinformatics-and-epigenetics-reveal-the-underlying-mechanisms-by-which-flot2-modulates-the-progression-of-diffuse-large-b-cell-lymphoma
#15
JOURNAL ARTICLE
Yujing Zhang, Yao Chen, Qiang Guo, Ying Zhang, Aichun Liu
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) poses a significant threat to the quality of life for people worldwide. Regrettably, effective treatment strategies for this disease remain elusive in clinical practice due to the unclear understanding of its molecular mechanisms. Therefore, this study was devised to address these issues and identify novel diagnostic, therapeutic, and prognostic biomarkers for DLBCL. METHODS: Gene expression and clinical data for DLBCL patients were retrieved from The Cancer Genome Atlas (TCGA) database, and relevant clinical data, tumor mutational burden (TMB), and gene expression levels were extracted...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531668/epidemiology-and-treatment-outcomes-of-tuberculosis-with-chronic-hepatitis-b-infection-california-2016-2020
#16
JOURNAL ARTICLE
J Bradford Bertumen, Lisa Pascopella, Emily Han, Rosie Glenn-Finer, Robert J Wong, Amit Chitnis, Devan Jaganath, Mirna Jewell, Prabhu Gounder, Sara McElroy, Lauren Stockman, Pennan Barry
BACKGROUND: Improved epidemiologic and treatment data for active tuberculosis (TB) with chronic hepatitis B virus (cHBV) infection might inform and encourage screening and vaccination programs focused on persons at risk of having both conditions. METHODS: We matched the California Department of Public Health TB registry during 2016-2020 to the cHBV registry using probabilistic matching algorithms. We used chi-square analysis to compare the characteristics of persons with TB and cHBV with those with TB only...
March 26, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38530799/regional-european-genetic-ancestry-predicts-type-i-interferon-level-and-risk-of-severe-viral-infection
#17
JOURNAL ARTICLE
Ilona Nln, Justine Shum, Yogita Ghodke-Puranik, Regine Tipon, Danielle Triese, Shreyasee Amin, Ashima Makol, Thomas Osborn, Vaidehi Chowdhary, Uma Thanarajasingam, Theresa L Wampler Muskardin, Vilija Oke, Iva Gunnarsson, Agneta Zickert, Maria I Zervou, Dimitrios T Boumpas, Elisabet Svenungsson, George N Goulielmos, Timothy B Niewold
BACKGROUND: Viral infection outcomes vary widely between individuals, ranging from mild symptoms to severe organ failure and death, and it is clear that host genetic factors play a role in this variability. Type I interferon (IFN) is a critical anti-viral cytokine, and we have previously noted differences in type I IFN levels between world populations. METHODS: In this study, we investigate the interrelationship between regional European genetic ancestry, type I IFN levels, and severe viral infection outcomes...
March 26, 2024: QJM: Monthly Journal of the Association of Physicians
https://read.qxmd.com/read/38530710/hiv-hbv-coinfection-understanding-the-complex-interactions-and-their-impact-on-spontaneous-hbv-clearance-chronic-liver-damage-cirrhosis-and-hepatocellular-carcinoma
#18
JOURNAL ARTICLE
Jingwen Xiao, Yongzheng Zhang, Jia Wu, Xinping -Chen, Wei Zou
Compared to either HIV or hepatitis B virus (HBV) monoinfected individuals, HIV/HBV-coinfected individuals have a decreased probability of spontaneous HBV clearance and a greater risk of developing chronic liver damage and a faster progression to cirrhosis and hepatocellular carcinoma. This manuscript attempts to provide a comprehensive review of the landscape of current HIV/HBV coinfection research with a focus on the intricate interactions between these two viruses. Our review will help understand the disease dynamics of HIV/HBV coinfection and has important implications for designing public health strategies...
2024: AIDS Reviews
https://read.qxmd.com/read/38530620/sodium-glucose-cotransporter-2-inhibitors-and-cancer-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
B Xu, B Kang, S Li, S Fan, J Zhou
BACKGROUND: The effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on cancer has yet to be fully elucidated. OBJECTIVE: This systematic review and meta-analysis investigated the effects of SGLT2 inhibitors on cancer. METHODS: We searched the PubMed and ClinicalTrials.gov databases up to July 15, 2023, to identify eligible randomized, double-blind, placebo-controlled trials that lasted at least ≥24 weeks. The primary outcome was the overall cancer incidence, and the secondary outcomes were the incidences of various types of cancer...
March 26, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38530519/therapeutic-effect-of-levetiracetam-against-thioacetamide-induced-hepatic-encephalopathy-through-inhibition-of-oxidative-stress-and-downregulation-of-nf-%C3%AE%C2%BAb-nlrp3-inos-no-pro-inflammatory-cytokines-and-apoptosis
#20
JOURNAL ARTICLE
Keyvan Amirshahrokhi, Mahsa Imani
Hepatic encephalopathy (HE) is a serious brain disorder which associated with neurological and psychiatric manifestations. Oxidative stress and neuroinflammation and apoptosis play main roles in the development of brain damage in HE. Levetiracetam is an antiseizure drug with established antioxidant and anti-inflammatory activities. In the present study we investigated the therapeutic effects of levetiracetam against brain injury in HE and its underlying mechanisms of action. Male C57BL/6 mice were subjected to the induction of HE by the injection of thioacetamide (200 mg/kg) for 2 days...
March 26, 2024: Inflammation
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