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Blood stream infections

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https://www.readbyqxmd.com/read/29649341/how-does-your-piccompare-a-pilot-randomized-controlled-trial-comparing-various-picc-materials-in-pediatrics
#1
Tricia Kleidon, Amanda J Ullman, Li Zhang, Gabor Mihala, Brett Chaseling, Jason Schoutrop, Claire M Rickard
BACKGROUND: Despite the popularity of peripherally inserted central catheters (PICCs), recent literature highlights their potential injurious complications. Innovative PICC materials have been developed to prevent thrombosis and infection formation (Endexo®) and antireflux valves to prevent occlusion (pressure-activated safety valve®). No large randomized controlled trial has assessed these technologies. Our primary aim was to evaluate the feasibility of a large randomized controlled efficacy trial of PICC materials and design to reduce PICC complication in pediatrics...
February 8, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29627326/one-percent-chlorhexidine-alcohol-for-preventing-central-venous-catheter-related-infection-during-intensive-chemotherapy-for-patients-with-haematologic-malignancies
#2
Shimon Ohtake, Hiromichi Takahashi, Masaru Nakagawa, Yoshihito Uchino, Katsuhiro Miura, Noriyoshi Iriyama, Tomohiro Nakayama, Yoshihiro Hatta, Masami Takei
A central venous catheter (CVC) is a catheter placed into a large vein, and is used for chemotherapy administration. However, there is little confirmatory data on which antiseptic-such as chlorhexidine or povidone-iodine (PI) -is more protective against CVC-related infectious complications in patients receiving intensive chemotherapy. We aimed to compare the effectiveness of 1% chlorhexidine gluconate in 70% alcohol (CH) vs. PI for skin disinfection before CVC insertion in patients receiving intensive chemotherapy...
April 4, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29621565/p-aeruginosa-blood-stream-infection-isolates-a-full-house-of-virulence-genes-in-isolates-associated-with-rapid-patient-death-and-patient-survival
#3
K L McCarthy, A M Wailan, A V Jennison, T J Kidd, D L Paterson
We have recently characterised the epidemiology of P. aeruginosa blood stream infection (BSI) in a large retrospective multicentre cohort study [1]. Utilising corresponding patient BSI isolates we aimed to characterise the genotypic virulence profile of the P. aeruginosa isolates that were associated with rapid death in the non-neutropenic host. Five P. aeruginosa BSI episodes were identified from a larger cohort of P. aeruginosa BSI episodes previously described by McCarthy et al. [1]. The genotypic profile of another 5 isolates from this cohort in whom the non-neutropenic host had survived one year post the BSI was also analysed for comparison...
April 2, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29615168/reasons-for-removal-of-non-tunneled-double-lumen-catheters-in-incident-dialysis-patients
#4
Ruqaya Qureshi, Beena Salman, Salman Imtiaz, Murtaza F Drohlia, Aasim Ahmad
OBJECTIVE: To evaluate the reasons of removal of non-tunneled double lumen catheters (NTDLC) in incident hemodialysis (HD) patients in a tertiary renal care hospital. STUDY DESIGN: Observational retrospective study. PLACE AND DURATION OF STUDY: Department of Nephrology, The Kidney Centre Postgraduate Training Institute (TKC PGTI), Karachi, from June 2015 to May 2016. METHODOLOGY: All patients were selected who had naive NTDLC placement at TKC PGTI either in Emergency Room (ER) or Intensive Care Unit (ICU) during the study period...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29607230/use-of-next-generation-sequencing-and-synergy-susceptibility-testing-in-diagnosis-and-treatment-of-carbapenem-resistant-klebsiella-pneumoniae-blood-stream-infection
#5
Yuetian Yu, Fupin Hu, Cheng Zhu, Erzhen Chen, Liangjing Lu, Yuan Gao
Early diagnosis and appropriate treatment for carbapenem-resistant Klebsiella pneumoniae (CR- Kp ) infection is a big challenge for clinicians due to its high mortality. Every effort has been made to improve its clinical outcomes. However, treatment according to synergy susceptibility testing has never been reported in the literature. We reported a 29-year-old systemic lupus erythematosus female with CR- Kp blood stream infection. We highlighted the identification by next generation sequencing and treatment according to synergy susceptibility testing in the case...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29593746/-plasmodium-falciparum-liver-stage-infection-and-transition-to-stable-blood-stage-infection-in-liver-humanized-and-blood-humanized-frgn-ko-mice-enables-testing-of-blood-stage-inhibitory-antibodies-reticulocyte-binding-protein-homolog-5-in-vivo
#6
Lander Foquet, Carola Schafer, Nana K Minkah, Daniel G W Alanine, Erika L Flannery, Ryan W J Steel, Brandon K Sack, Nelly Camargo, Matthew Fishbaugher, Will Betz, Thao Nguyen, Zachary P Billman, Elizabeth M Wilson, John Bial, Sean C Murphy, Simon J Draper, Sebastian A Mikolajczak, Stefan H I Kappe
The invention of liver-humanized mouse models has made it possible to directly study the preerythrocytic stages of Plasmodium falciparum . In contrast, the current models to directly study blood stage infection in vivo are extremely limited. Humanization of the mouse blood stream is achievable by frequent injections of human red blood cells (hRBCs) and is currently the only system with which to study human malaria blood stage infections in a small animal model. Infections have been primarily achieved by direct injection of P...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29569379/risk-factors-for-blood-stream-infections-in-multiple-myeloma-a-population-based-study-of-1154-patients-in-denmark
#7
Rasmus Sørrig, Tobias W Klausen, Morten Salomo, Annette Vangsted, Peter Gimsing
OBJECTIVES: Multiple Myeloma (MM) patients are at high risk of developing infections. The risk factors for blood stream infections (BSI) in MM patients are however less described. The aim of this study was to analyze the epidemiology of and risk factors for BSI in an unselected MM population. METHODS: Nationwide Danish MM data of 1154 patients diagnosed from 2010-2013 was linked with nationwide data on blood cultures (BCs) (from 2010-2016) to assess the peak period of having a BC taken and BC positive for pathogenic microorganisms...
March 22, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29551362/evaluation-of-sepsis-flow-chip-for-identification-of-gram-negative-bacilli-and-detection-of-antimicrobial-resistance-genes-directly-from-positive-blood-cultures
#8
Carlos Rodríguez-Lucas, M Rosario Rodicio, Isabel Costales, José Antonio Boga, Fernando Vazquez, Javier Fernández
Blood stream infections are serious conditions associated with high morbi-mortality. In this study, the new Sepsis Flow Chip (SFC) assay for identification of Gram-negative bacteria and their antimicrobial resistance genes was evaluated in positive blood cultures (BCs). SFC is a microarray with a broad panel comprising the most frequent causative agents of sepsis and antimicrobial resistance genes associated with them. A total of 100 prospective BCs, positive for Gram-negative bacilli, were assessed in the routine of the clinical microbiology laboratory and also applying the SFC assay...
February 14, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29548778/detection-of-the-meca-gene-and-identification-of-staphylococcus-directly-from-blood-culture-bottles-by-multiplex-polymerase-chain-reaction
#9
Taisa Trevizani Rocchetti, Katheryne Benine Martins, Patricia Yoshida Faccioli Martins, Rogério Antonio de Oliveira, Alessandro Lia Mondelli, Carlos Magno Castelo Branco Fortaleza, Maria de Lourdes Ribeiro de Souza da Cunha
INTRODUCTION: Staphylococcus spp. - both S. aureus, including methicillin-resistant strains (MRSA) and coagulase negative staphylococci (CoNS) - are relevant agents of healthcare-associated infections. Therefore, the rapid recognition of MRSA and methicillin-resistant CoNS from blood stream infections is critically important for patient management. It is worth noting that inappropriate empiric therapy has been associated with higher in-hospital mortality. MATERIAL AND METHODS: In this study we evaluated a multiplex PCR standardized to detect Staphylococcus spp...
March 13, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29546772/peripherally-inserted-central-catheters-in-the-treatment-of-children-with-cancer-results-of-a-multicenter-study
#10
Maxim Yu Rykov, Sergei V Zaborovskij, Alexander N Shvecov, Vladimir V Shukin
PURPOSE: To review our experience with peripherally inserted central catheters in pediatric cancer patients. METHODS: The analysis included 353 patients (3 months up to 17 years, mean age 11.2 years) with a variety of cancers diseases, which in 2011-2016, 354 peripherally inserted central catheters were placed. All settings are carried out using ultrasound guidance. In 138 (39%) patients, external anatomical landmarks were used and in 216 (61%) intraoperative fluoroscopy...
March 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29546615/blood-stream-infection-is-associated-with-cerebrovascular-accident-in-patients-with-left-ventricular-assist-device-a-systematic-review-and-meta-analysis
#11
Napatt Kanjanahattakij, Benjamin Horn, Basma Abdulhadi, Nicha Wongjarupong, Kenechukwu Mezue, Pattara Rattanawong
Cerebrovascular accident (CVA) is one of the major complications and a leading cause of death in patients with a left ventricular assist device (LVAD). Multiple studies of have shown that patients with blood stream infection (BSI) are more likely to develop CVA compared to patients without BSI. However, there is no meta-analysis to confirm this association. Studies were systematically acquired from MEDLINE and EMBASE electronic databases. Included studies assessed patients with heart failure requiring LVAD and reported the number of patients who had BSI post LVAD, incidence of ischemic CVA, hemorrhagic CVA, or any CVA...
March 16, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29543306/nurses-compliance-with-central-line-associated-blood-stream-infection-prevention-guidelines
#12
Sami M Aloush, Faris A Alsaraireh
OBJECTIVE:  To assess nurses' compliance with central line associated bloodstream infection (CLABSI) prevention guidelines related to maintenance of the central line and the predictors of compliance. Method: This was an observational study that used a descriptive cross-sectional design. A sample of 171 intensive care unit (ICU) nurses were observed and their compliance was recorded on a structured observational sheet. The study was conducted in the ICUs of 15 hospitals located in 5 cities in Jordan...
March 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29521021/nkg2d-ligands-putting-everything-under-the-same-umbrella-can-be-misleading
#13
REVIEW
C Campos-Silva, M K Kramer, M Valés-Gómez
NKG2D is a key receptor for the activation of immune effector cells, mainly Natural Killer cells and T lymphocytes, in infection, cancer and autoimmune diseases. Since the detection of ligands for NKG2D in sera of cancer patients is, in many human models, indicative of prognosis, a large number of studies have been undertaken to improve understanding of the biology regulating this receptor and its ligands, with the aim of translating this knowledge into clinical practice. Although it is becoming clear that the NKG2D system can be used as a tool for diagnosis and manipulated for therapy, some questions remain open due to the complexity associated with the existence of a large number of ligands, each one of them displaying distinct biological properties...
March 9, 2018: HLA
https://www.readbyqxmd.com/read/29518552/early-blood-stream-infection-after-bmt-is-associated-with-cytokine-dysregulation-and-poor-overall-survival
#14
Elizabeth M Catchpoole, Caitlin E Thirunavukarasu, Antiopi Varelias, Sanmarié Schlebusch, Stuart Olver, Nienke Zomerdijk, Emma Osland, Glen A Kennedy, Siok-Keen Tey, Geoffrey R Hill, Kate A Markey
The key complications of allogeneic bone marrow transplant (BMT) remain graft-versus-host disease (GVHD) and opportunistic infection. We have analyzed the blood stream infections (BSI) occurring between day -7 and day 100 in a cohort of 184 adult patients undergoing allogeneic BMT in our center. 167 of the 184 patients (91%) had blood cultures collected, and 69 (38%) patients had a confirmed BSI. Enterobacteriaceae, Pseudomonas aeruginosa, Enterococcus spp. and viridans Streptococcus spp. were the most commonly isolated organisms...
March 5, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29518133/icu-mortality-following-icu-acquired-primary-bloodstream-infections-according-to-the-type-of-pathogen-a-prospective-cohort-study-in-937-germany-icus-2006-2015
#15
Frank Schwab, Christine Geffers, Michael Behnke, Petra Gastmeier
OBJECTIVE: Mortality due to intensive care unit (ICU) acquired primary blood stream infections (PBSI) is related primarily to patient co-morbidities, types of pathogens and quality of care. The objective of this study is to determine the impact of various types of pathogen on ICU mortality. METHODS: Data from the German National Nosocomial Infection Surveillance System of patients with PBSI from 2006 to 2015 was used for this analysis. A BSI is primary when the pathogen recognized is not related to an infection on another site...
2018: PloS One
https://www.readbyqxmd.com/read/29514546/efficacy-and-safety-of-peripherally-inserted-central-venous-catheters-in-acute-cardiac-care-management
#16
Fabrizio Poletti, Claudio Coccino, Davide Monolo, Paolo Crespi, Giorgio Ciccioli, Giuseppe Cordio, Giovanni Seveso, Stefano De Servi
PURPOSE: Patients admitted to cardiac intensive care unit need administration of drugs intravenously often in concomitance of therapeutic techniques such as non-invasive ventilation, continuous renal replacement therapy and intra-aortic balloon counterpulsation. Therefore, the insertion of central venous catheters provides a reliable access for delivering medications, laboratory testing and hemodynamic monitoring, but it is associated with the risk of important complications. In our study, we tested the efficacy and safety of peripherally inserted central catheters to manage cardiac intensive care...
March 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29512818/antibiotics-at-the-time-of-removal-of-central-venous-catheter-to-reduce-morbidity-and-mortality-in-newborn-infants
#17
REVIEW
Rowena L McMullan, Adrienne Gordon
BACKGROUND: Late-onset sepsis is associated with increased rates of mortality and morbidity in newborn infants, in addition to poorer long-term developmental outcomes and increased length of stay and hospital costs. Central line-associated blood stream infection (CLABSI) is the most common cause of late-onset sepsis in hospitalised infants, and prevention of CLABSI is a key objective in neonatal care. Increased frequency of CLABSI around the time of removal of central venous catheters (CVCs) has been reported, and use of antibiotics at the time of removal may reduce the incidence and impact of late-onset sepsis in vulnerable newborn infants...
March 7, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29499845/anticoagulation-results-in-increased-line-salvage-for-children-with-intestinal-failure-and-central-venous-thrombosis
#18
Cory M McLaughlin, Monica Bennett, Nandini Channabasappa, Janna Journeycake, Hannah G Piper
PURPOSE: The purpose of this study was to investigate whether anticoagulation (AC) results in thrombus resolution and increased line longevity in children with intestinal failure (IF) and catheter-associated central venous thrombosis (CVT). METHODS: A retrospective, single institution review was performed of children with IF who were dependent on parenteral nutrition with known CVT between 2006 and 2017. Frequency of catheter-related complications including infection, occlusion, and breakage were compared 18months prior to and after starting AC...
February 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29492929/aeromonas-spp-human-infection-retrospective-study-in-the-region-of-sousse-2011-2015
#19
Hichem Bargui, Manel Marzouk, Ahmed Benhadj, Moufida Hadj Ali, Youssef Ben Salem, Jalel Boukadida
OBJECTIVE: To present the clinical and bacteriological characteristics of human Aeromonas infections in the central region of Tunisia from January 2011 to September 2015. METHODS: Retrospective study concerning all Aeromonas spp strains isolated at our laboratory during a period of 5 years (2011-2015). Following data were collected: gender, age, hospital department, co-morbidities, site of infection, date, the Aeromonas species and susceptibility phenotype. Identification was based on conventional criteria and antibiotic susceptibility was performed according to the recommendations of "the Committee of the French Society of Microbiology...
April 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29469352/-survey-of-epidemic-status-of-paragonimiasis-in-western-mountainous-areas-in-hubei-province
#20
Dong Xiao-Rong, Zhang Hua-Xun, Cao Mu-Min, Wu Dong-Ni, Xia Jing
OBJECTIVE: To understand the current status of paragonimiasis epidemic in western mountain areas in Hubei Province. METHODS: Four counties (cities) of Western Hubei Province (Xingshan, Enshi, Yunxi, Baokang) were selected as the investigation sites for active surveillance. Crabs were captured and the metacercariae of Paragonimus were detected. Meanwhile, the blood samples were collected from the residents in the surveillance sites and the unique IgG and IgM antibodies against Paragonimus in the sera were detected by ELISA...
July 5, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
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