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https://www.readbyqxmd.com/read/28448903/violence-trauma-and-living-with-hiv-longitudinal-predictors-of-initiating-crystal-methamphetamine-injection-among-sex-workers
#1
Elena Argento, Steffanie A Strathdee, Shira Goldenberg, Melissa Braschel, Julio Montaner, Kate Shannon
BACKGROUND: Despite rapid increases in crystal methamphetamine (CM) use worldwide and established gendered patterns of use, empirical research on CM injection initiation among sex workers is limited. Given the wide range of harms associated with CM, alongside stimulant effects including sexual dis-inhibition and prolonged awake-ness, this study aimed to longitudinally investigate socio-structural predictors of initiating CM injection among sex workers in Vancouver, Canada. METHODS: Data (2010-2014) were drawn from a community-based cohort of women sex workers: AESHA (An Evaluation of Sex Workers Health Access)...
April 19, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28447836/the-goldilocks-contract-the-synergistic-benefits-of-combining-structure-and-autonomy-for-persistence-creativity-and-cooperation
#2
Eileen Y Chou, Nir Halevy, Adam D Galinsky, J Keith Murnighan
Contracts are commonly used to regulate a wide range of interactions and relationships. Yet relying on contracts as a mechanism of control often comes at a cost to motivation. Integrating theoretical perspectives from psychology, economics, and organizational theory, we explore this control-motivation dilemma inherent in contracts and present the Contract-Autonomy-Motivation-Performance-Structure (CAMPS) model, which highlights the synergistic benefits of combining structure and autonomy. The model proposes that subtle reductions in the specificity of a contract's language can boost autonomy, which increases intrinsic motivation and improves a range of desirable behaviors...
April 27, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28447245/neuroanatomical-variations-as-a-function-of-experience-in-a-complex-daily-task-a-vbm-and-dti-study-on-driving-experience
#3
Alberto Megías, D Petrova, J F Navas, A Cándido, A Maldonado, A Catena
Complex tasks require the learning and integration of multiple cognitive, sensory, and psychomotor skills for correct execution. Driving-related skills are developed step by step through the increase of mileage driven and the accumulation of practice in different traffic situations. The acquisition of these skills should be reflected in the brain structure. However, no previous studies have explored brain structural variations associated with driving experience. The aim of the present study was to investigate whether driving frequency, defined as average annual driving mileage, is related to neuroanatomical variations in gray matter (GM) volume and white matter (WM) integrity using voxel-based morphometry (VBM) and DTI-based fractional anisotropy (FA), respectively...
April 26, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28445826/exposure-to-fine-particulate-matter-causes-oxidative-and-methylated-dna-damage-in-young-adults-a-longitudinal-study
#4
Ching-Huang Lai, Han-Bin Huang, Yue-Cune Chang, Ting-Yao Su, Ying-Chuan Wang, Gia-Chi Wang, Jia-En Chen, Chin-Sheng Tang, Trong-Neng Wu, Saou-Hsing Liou
An increased understanding is needed of the physiological effects and plausible biological mechanisms that link PM2.5 (particulate matter with an aerodynamic diameter below 2.5μm) exposure to mortality and morbidities such as atherosclerosis and respiratory disease. PM2.5 causes carcinogenic health effects. Biomonitoring in humans has suggested that 8-oxo-7, 8-dihydro-2-deoxyguanosine (8-oxodG) and N7-methylguanine (N7-MeG) are correlated with oxidative and methylated DNA damage. Thus, it is meaningful to explore the mechanisms of mutagenesis and carcinogenesis associated with oxidative and methylated DNA damage by simultaneously measuring these two markers...
April 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28444781/constructing-longitudinal-disease-progression-curves-using-sparse-short-term-individual-data-with-an-application-to-alzheimer-s-disease
#5
C A Budgeon, K Murray, B A Turlach, S Baker, V L Villemagne, S C Burnham
In epidemiology, cohort studies utilised to monitor and assess disease status and progression often result in short-term and sparse follow-up data. Thus, gaining an understanding of the full-term disease pathogenesis can be difficult, requiring shorter-term data from many individuals to be collated. We investigate and evaluate methods to construct and quantify the underlying long-term longitudinal trajectories for disease markers using short-term follow-up data, specifically applied to Alzheimer's disease. We generate individuals' follow-up data to investigate approaches to this problem adopting a four-step modelling approach that (i) determines individual slopes and anchor points for their short-term trajectory, (ii) fits polynomials to these slopes and anchor points, (iii) integrates the reciprocated polynomials and (iv) inverts the resulting curve providing an estimate of the underlying longitudinal trajectory...
April 25, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28444239/the-influence-of-social-conditions-across-the-life-course-on-the-human-gut-microbiota-a-pilot-project-with-the-wisconsin-longitudinal-study
#6
Pamela Herd, Nora Cate Schaeffer, Kerryann DiLoreto, Karen Jacques, John Stevenson, Federico Rey, Carol Roan
Objective: To test the feasibility of collecting and integrating data on the gut microbiome into one of the most comprehensive longitudinal studies of aging and health, the Wisconsin Longitudinal Study (WLS). The long-term goal of this integration is to clarify the contribution of social conditions in shaping the composition of the gut microbiota late in life. Research on the microbiome, which is considered to be of parallel importance to human health as the human genome, has been hindered by human studies with nonrandomly selected samples and with limited data on social conditions over the life course...
April 25, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28441230/cochlear-implantation-in-adults-with-asymmetric-hearing-loss-benefits-of-bimodal-stimulation
#7
Maarten Caspar van Loon, Cas Smits, Conrad F Smit, Erik F Hensen, Paul Merkus
OBJECTIVE: This study addresses the outcome of cochlear implantation in addition to hearing aid use in patients with asymmetric sensorineural hearing loss. STUDY DESIGN: Prospective longitudinal study. SETTING: Tertiary referral center. PATIENTS: Seven adults with asymmetric sensorineural hearing loss, i.e., less than 30% aided speech recognition in their worst hearing ear and 60 to 85% speech recognition in their best hearing ear...
April 24, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28438836/a-wnt-notch-pax7-signaling-network-supports-tissue-integrity-in-tongue-development
#8
Xiao-Jing Zhu, Xueyan Yuan, Min Wang, Yukun Fang, Yudong Liu, Xiaoyun Zhang, Xueqin Yang, Yan Li, Jianying Li, Feixue Li, Zhong-Min Dai, Mengsheng Qiu, Ze Zhang, Zunyi Zhang
The tongue is one of the major structures involved in human food intake and speech. Tongue malformations such as aglossia, microglossia, and ankyloglossia are congenital birth defects, greatly affecting individuals' quality of life. However, the molecular basis of the tissue-tissue interactions that ensure tissue morphogenesis to form a functional tongue remains largely unknown. Here we show that ShhCre-mediated epithelial deletion of Wntless (Wls), the key regulator for intracellular Wnt trafficking, leads to lingual hypoplasia in mice...
April 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28437721/optimizing-follow-up-and-study-retention-in-the-21st-century-advances-from-the-front-line-in-alcohol-and-tobacco-research
#9
Lia J Smith, Patrick J McNamara, Andrea C King
AIMS: Longitudinal studies are integral in addiction research but retention of participants over time can be challenging. While statistical algorithms for missing data have advanced, they remain less desirable than collecting actual data with high retention rates. An update to methodological primers with consideration of evolving technology and privacy concerns is needed for 21st century researchers. METHODS: Comprehensive follow-up methodological strategies were conducted in four concurrent laboratory- and intervention-based studies across N=697 drinker and smokers enrolled in studies at the Clinical Addictions Research Laboratory at the University of Chicago...
April 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28437358/integrated-multidimensional-maturity-assessments-predicting-the-high-risk-occurrence-of-peak-angle-velocity-during-puberty-in-progressive-female-idiopathic-scoliosis
#10
Benlong Shi, Saihu Mao, Leilei Xu, Xu Sun, Zezhang Zhu, Bangping Qian, Zhen Liu, Jack Chun Yiu Cheng, Yong Qiu
STUDY DESIGN: A consecutive and prospective longitudinal study. OBJECTIVE: To propose an integrated multidimensional maturity assessment that was designated as forming a reliable system precisely predicting the high-risk occurrence of peak angle velocity (PAV) in a group of progressive braced female idiopathic scoliosis (IS). SUMMARY OF BACKGROUND DATA: Scoliosis deterioration is believed to keep pace with the evolution of skeletal maturity during puberty...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28434744/a-prospective-cohort-study-of-digital-cushion-and-corium-thickness-part-1-associations-with-body-condition-lesion-incidence-and-proximity-to-calving
#11
R F Newsome, M J Green, N J Bell, N J Bollard, C S Mason, H R Whay, J N Huxley
Claw horn disruption lesions (CHDL) are a major cause of lameness in dairy cattle and are likely a result of excessive forces being applied to the germinal epithelium that produces the claw horn. The digital cushion is a connective tissue structure, containing depots of adipose tissue, that sits beneath the distal phalanx and has been shown to be thicker in fatter cows. Body condition score (BCS) loss is a risk factor for CHDL, and one possible explanation is that fat is mobilized from the digital cushion during negative energy balance, causing the digital cushion to thin and lose force-dissipating capacity, leading to disruption of claw horn growth...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28434731/a-prospective-cohort-study-of-digital-cushion-and-corium-thickness-part-2-does-thinning-of-the-digital-cushion-and-corium-lead-to-lameness-and-claw-horn-disruption-lesions
#12
R F Newsome, M J Green, N J Bell, N J Bollard, C S Mason, H R Whay, J N Huxley
The aim of this study was to determine whether a decrease in thickness of the sole soft tissues (SST) beneath the flexor tuberosity of the distal phalanx (i.e., the digital cushion and corium) predisposed a claw to develop claw horn disruption lesions (CHDL) or a leg to lameness. Data were analyzed from a longitudinal study of 179 cows, which had been examined at 5 assessment points -8, +1, +9, +17, and +29 wk relative to their first, second, third, or fourth calving. At each assessment point, SST were measured using ultrasonography...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28434055/addressing-methodologic-challenges-and-minimizing-threats-to-validity-in-synthesizing-findings-from-individual-level-data-across-longitudinal-randomized-trials
#13
Ahnalee Brincks, Samantha Montag, George W Howe, Shi Huang, Juned Siddique, Soyeon Ahn, Irwin N Sandler, Hilda Pantin, C Hendricks Brown
Integrative Data Analysis (IDA) encompasses a collection of methods for data synthesis that pools participant-level data across multiple studies. Compared with single-study analyses, IDA provides larger sample sizes, better representation of participant characteristics, and often increased statistical power. Many of the methods currently available for IDA have focused on examining developmental changes using longitudinal observational studies employing different measures across time and study. However, IDA can also be useful in synthesizing across multiple randomized clinical trials to improve our understanding of the comprehensive effectiveness of interventions, as well as mediators and moderators of those effects...
April 22, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28432057/imaging-and-modeling-of-acute-pressure-induced-changes-of-collagen-and-elastin-microarchitectures-in-pig-and-human-resistance-arteries
#14
Maria Bloksgaard, Thomas M Leurgans, Bart Spronck, Maarten Hg Heusinkveld, Bjarne Thorsted, Kristoffer Rosenstand, Inger Nissen, Ulla Melchior Hansen, Jonathan R Brewer, Luis A Bagatolli, Lars M Rasmussen, Akhmadjon Irmukhamedov, Koen D Reesink, Jo G R De Mey
The impact of disease related changes in the extracellular matrix (ECM) on the mechanical properties of human resistance arteries largely remains to be established. Resistance arteries from both pig and human parietal pericardium (PRA) display a different ECM microarchitecture compared to frequently used rodent mesenteric arteries. We hypothesized that the biaxial mechanics of PRA mirror pressure induced changes in the ECM microarchitecture. This was tested using isolated pig PRA as model system, integrating vital imaging, pressure myography and mathematical modeling...
April 21, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28429371/design-of-a-short-non-uniform-acquisition-protocol-for-quantitative-analysis-in-dynamic-cardiac-spect-imaging-a-retrospective-123-i-mibg-animal-study
#15
Yunlong Zan, Yong Long, Kewei Chen, Biao Li, Qiu Huang, Grant T Gullberg
PURPOSE: Our previous works have found that quantitative analysis of (123) I-MIBG kinetics in the heart with dynamic single-photon emission computed tomography (SPECT) offers the potential to quantify the innervation integrity at an early stage of left ventricular hypertrophy. However, conventional protocols involving a long acquisition time for dynamic imaging reduce the animal survival rate and thus make longitudinal analysis difficult. The goal of this work was to develop a procedure to reduce the total acquisition time by selecting non-uniform acquisition times for projection views while maintaining the accuracy and precision of estimated physiologic parameters...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28427051/subjective-time-perceptions-and-aging-well-a-review-of-concepts-and-empirical-research-a-mini-review
#16
Martina Gabrian, Anne J Dutt, Hans-Werner Wahl
Human beings impose subjective, time-related interpretations on their existence, and the experience of time is a major aspect of lifespan development. In this mini-review, we understand subjective time as the way individuals subjectively perceive and evaluate the passing of their personal "objective" lifetime. A broad range of constructs and operationalizations has been developed in (gero-) psychology to capture subjective time, including future time perspective, personal goals, or autobiographical memories...
April 21, 2017: Gerontology
https://www.readbyqxmd.com/read/28426945/testosterone-levels-in-healthy-men-correlate-negatively-with-serotonin-4-receptor-binding
#17
Erik Perfalk, Sofi da Cunha-Bang, Klaus K Holst, Sune Keller, Claus Svarer, Gitte M Knudsen, Vibe G Frokjaer
The serotonergic system integrates sex steroid information and plays a central role in mood and stress regulation, cognition, appetite and sleep. This interplay may be critical for likelihood of developing depressive episodes, at least in a subgroup of sensitive individuals. The serotonin 4 receptor (5-HT4R) indexes central serotonergic tonus, which may be related to endogenous sex-steroid levels in the mentally healthy state even though this remains elusive. Here we evaluate if peripheral levels of estradiol and testosterone are associated with 5-HT4R binding as imaged by [(11)C]SB207145 positron emission tomography in a group of 41 healthy men...
March 22, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28426759/health-related-quality-of-life-in-south-african-patients-with-pulmonary-tuberculosis
#18
Tanja Kastien-Hilka, Bernd Rosenkranz, Edina Sinanovic, Bryan Bennett, Matthias Schwenkglenks
BACKGROUND: The evaluation of patient-reported health-related quality of life (HRQOL) in pulmonary tuberculosis (TB) contributes to a comprehensive understanding of the burden associated with this disease. The aim of this study was to assess the overall impact of TB on the health status and on single health domains identified in the WHO definition of health, including physical, mental and social health aspects. METHODS: Four instruments for HRQOL evaluation were applied in a longitudinal multicentre study during six-month standard TB treatment in South Africa...
2017: PloS One
https://www.readbyqxmd.com/read/28426755/correction-limbic-thalamo-cortical-projections-and-reward-related-circuitry-integrity-affects-eating-behavior-a-longitudinal-dti-study-in-adolescents-with-restrictive-eating-disorders
#19
Gaia Olivo, Lyle Wiemerslage, Ingemar Swenne, Christina Zhukovsky, Helena Salonen-Ros, Elna-Marie Larsson, Santino Gaudio, Samantha J Brooks, Helgi B Schiöth
[This corrects the article DOI: 10.1371/journal.pone.0172129.].
2017: PloS One
https://www.readbyqxmd.com/read/28425561/creating-homogenous-strain-distribution-within-3d-cell-encapsulated-constructs-using-a-simple-and-cost-effective-uniaxial-tensile-bioreactor-design-and-validation-study
#20
Gayathri Subramanian, Mostafa Elsaadany, Callan Bialorucki, Eda Yildirim-Ayan
Mechanical loading bioreactors capable of applying uniaxial tensile strains are emerging to be a valuable tool to investigate physiologically-relevant cellular signaling pathways and biochemical expression. In this study, we have introduced a simple and cost-effective uniaxial tensile strain bioreactor for the application of precise and homogenous uniaxial strains to 3D cell-encapsulated collagen constructs at physiological loading strains (0-12%) and frequencies (0.01-1 Hz). The bioreactor employs silicone-based loading chambers specifically designed to stretch constructs without direct gripping to minimize stress concentration at the ends of the construct and preserve its integrity...
April 20, 2017: Biotechnology and Bioengineering
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