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https://www.readbyqxmd.com/read/29652114/associations-between-vitamin-d-levels-and-polycystic-ovary-syndrome-pcos-phenotypes
#1
Erin M Davis, Jennifer D Peck, Karl R Hansen, Barbara R Neas, LaTasha B Craig
BACKGROUND: Studies comparing serum 25-hydroxyvitamin D concentrations in women with and without PCOS have produced inconsistent results. Additionally, no previous studies have evaluated associations between vitamin D and specific PCOS phenotypes. METHODS: This case-control study was conducted among women undergoing intrauterine insemination. Cases (n=137) were diagnosed with PCOS and then further classified into 3 diagnostic phenotypes based on combinations of the Rotterdam criteria [ovulatory dysfunction +polycystic ovaries (n=55); ovulatory dysfunction +androgen excess (n=15); and ovulatory dysfunction, +polycystic ovaries, +androgen excess (n=67)]...
April 12, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29649996/the-effects-of-synbiotic-supplementation-on-hormonal-status-biomarkers-of-inflammation-and-oxidative-stress-in-subjects-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#2
Khadijeh Nasri, Mehri Jamilian, Elham Rahmani, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Zatollah Asemi
BACKGROUND: To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PCOS). This research was done to assess the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with PCOS. METHODS: This randomized double-blind, placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria...
April 12, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29648599/polycystic-ovary-syndrome-is-associated-with-adverse-mental-health-and-neurodevelopmental-outcomes
#3
Thomas R Berni, Christopher L Morgan, Ellen R Berni, D Aled Rees
Context: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and subfertility but the effects on mental health and child neurodevelopment are unclear. Objectives: To determine if (i) there is an association between PCOS and psychiatric outcomes, and (ii) whether rates of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are higher in children of mothers with PCOS. Design: Data were extracted from the Clinical Practice Research Datalink...
April 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29648472/downregulation-of-serum-long-noncoding-rna-gas5-may-contribute-to-insulin-resistance-in-pcos-patients
#4
Haiyan Lin, Weijie Xing, Yu Li, Yanxin Xie, Xiaoshi Tang, Qingxue Zhang
Polycystic ovary syndrome (PCOS) is a common endocrine disease that affects reproductive-aged women and mostly characterized by insulin resistance (IR). The underlying mechanism remains unknown. Long noncoding RNAs (lncRNAs) have been demonstrated to be involved in various levels of biological regulation process of cell development, metabolism, and differentiation. This study aims to investigate the relationship between IR and differential expression of lncRNA Growth-arrest specific transcript 5 (GAS5) in patients' serum with and without PCOS...
April 12, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29644330/pregnancy-complications-in-infertile-patients-with-polycystic-ovary-syndrome-updated-evidences
#5
Stefano Palomba, Angela Falbo, Jessica Daolio, Francesco A Battaglia, Giovanni B LA Sala
Polycystic ovary syndrome (PCOS) is a common female disorder with a pathogenesis still today not completely known. To the present, PCOS is considered more than just a reproductive disorder since several metabolic consequences that could affect women's health during different stages of reproductive and post-reproductive life were reported. The aim of the current review was to evaluate present evidence-based data regarding the pregnancy complications in infertile patients with PCOS. An extensive literature search until February 2018 was performed in PubMed, Medline, the Cochrane Library and Web of Science...
April 11, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29642911/gnrh-dysregulation-in-polycystic-ovarian-syndrome-pcos-is-a-manifestation-of-an-altered-neurotransmitter-profile
#6
Nirja Chaudhari, Mitali Dawalbhakta, Laxmipriya Nampoothiri
BACKGROUND: GnRH is the master molecule of reproduction that is influenced by several intrinsic and extrinsic factors such as neurotransmitters and neuropeptides. Any alteration in these regulatory loops may result in reproductive-endocrine dysfunction such as the polycystic ovarian syndrome (PCOS). Although low dopaminergic tone has been associated with PCOS, the role of neurotransmitters in PCOS remains unknown. The present study was therefore aimed at understanding the status of GnRH regulatory neurotransmitters to decipher the neuroendocrine pathology in PCOS...
April 11, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29630096/effects-of-testosterone-on-ppar%C3%AE-and-p450arom-expression-in-polycystic-ovary-syndrome-patients-and-related-mechanisms
#7
Y He, C-L Wang
OBJECTIVE: Polycystic ovary syndrome (PCOS) causes ovulation disorder and infertility in female patients. This study recruited PCOS patients and adopted testosterone therapy to analyze its effect on expression of nuclear peroxisome proliferation activated receptor γ (PPARγ), and cytochrome P450 aromatase (P450arom) in ovary granular cells of patients. PATIENTS AND METHODS: PCOS and non-PCOS patients were treated with testosterone at 1.0 nmol/L, 10 nmol/L. qRT-PCR was used to detect the expressions of PPARγ and P450arom while Western blot was performed for the evaluation of protein expression...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29629043/lower-levels-of-serum-adiponectin-and-the-t-allele-of-rs1501299-of-the-adipoq-gene-are-protective-against-polycystic-ovarian-syndrome-in-jordan
#8
Mahmoud A Alfaqih, Yousef S Khader, Ahmed N Al-Dwairi, Abdallah Alzoubi, Othman Al-Shboul, Amanie Hatim
Background: Polycystic ovary syndrome (PCOS) is a common reproductive disorder. Obesity, which is linked with lower adiponectin levels, increases a woman's risk of developing PCOS; however, the association between adiponectin and PCOS is controversial. Adiponectin levels could be affected by single nucleotide polymorphisms (SNPs) in the ADIPOQ gene. This study aimed to test the relationship between serum adiponectin and PCOS in Jordan and the association between the rs2241766, rs1501299, and rs266729 SNPs in the ADIPOQ gene and PCOS...
March 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29627845/eicosapentaenoic-acid-improves-polycystic-ovary-syndrome-in-rats-via-sterol-regulatory-element-binding-protein-1-srebp-1-toll-like-receptor-4-tlr4-pathway
#9
Yanting Wang, Jinying He, Jing Yang
BACKGROUND This study aimed to investigate the protective effect of eicosapentaenoic acid (EPA) on rats with polycystic ovary syndrome (PCOS). MATERIAL AND METHODS Rats with PCOS were intraperitoneally injected with different doses of EPA. Levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) were measured using corresponding kits. HE staining was used to observe lesions in ovarian tissue. Levels of inflammatory factors in ovarian tissue of rats were detected by ELISA...
April 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29624102/exogenous-testosterone-does-not-induce-or-exacerbate-the-metabolic-features-associated-with-pcos-among-transgender-men
#10
Kelly J Chan, Jennifer J Liang, Divya Jolly, Jamie D Weinand, Joshua D Safer
OBJECTIVES: Polycystic ovarian syndrome (PCOS) is a complex condition which can include menstrual irregularity, metabolic derangement, and increased androgen levels. The mechanism of PCOS is unknown. Some suggest that excess production of androgens by the ovaries may cause or exacerbate the metabolic findings. The purpose of this study was to assess the role of increased testosterone on metabolic parameters on individuals presumed to be chromosomally female by examination of these parameters in hormone-treated transgender men...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29622662/potential-genetic-polymorphisms-predicting-polycystic-ovary-syndrome
#11
Yao Chen, Shu-Ying Fang
Polycystic ovary syndrome (PCOS) is a heterogenous endocrine disorder with typical symptoms of oligomenorrhoea, hyperandrogenism, hirsutism, obesity, insulin resistance and increased risk of type 2 diabetes mellitus. Extensive evidence indicates that PCOS is a genetic disease and numerous biochemical pathways have been linked with its pathogenesis. A number of genes from these pathways have been investigated, which include those involved with steroid hormone biosynthesis and metabolism, action of gonadotropin and gonadal hormones, folliculogenesis, obesity and energy regulation, insulin secretion and action and many others...
April 5, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29621865/polycystic-ovary-syndrome
#12
Emma Ellis, Melanie Gibson-Helm, Jacqueline A Boyle
<p>Some components of recommended PCOS care were provided at high levels, including correct application of diagnostic criteria. However, PCOS management and screening for complications are being applied inconsistently in a population with high levels of cardiometabolic and emotional wellbeing risk.</p> <div class="hor-line">&nbsp;</div>.
April 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29620956/clinical-hormonal-and-metabolic-parameters-in-women-with-subclinical-hypothyroidism-and-polycystic-ovary-syndrome-a-cross-sectional-study
#13
Mohamed A Bedaiwy, Mohamed Y Abdel-Rahman, Justin Tan, Faten F AbdelHafez, Amr O Abdelkareem, Drisana Henry, Sarka Lisonkova, William W Hurd, James H Liu
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive age women, yet its clinical presentation shares similarities with several other endocrine disorders such as thyroid disease. Hence, the objective of this study was to further evaluate this association by investigating the clinical, hormonal, and metabolic parameters between subclinical hypothyroidism (SCH) and PCOS. METHODS: This is a cross-sectional study conducted in a tertiary care clinic at Cleveland, Ohio, USA...
April 5, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29620584/endometrial-carcinoma-with-an-unusual-morphology-in-a-patient-with-cornelia-de-lange-syndrome-a-case-study
#14
Keisei Tate, Hiroshi Yoshida, Mitsuya Ishikawa, Hanako Shimizu, Takashi Uehara, Tomoyasu Kato
Cornelia de Lange syndrome (CdLS) is a cohesinopathy, which is characterized by multiple structural anomalies as well as mental and growth retardation. A 36-yr-old nulliparous woman with oligomenorrhea was referred to us due to a mass in the uterine corpus. She had been clinically diagnosed with CdLS during infancy based on her specific facial features as well as growth and intellectual retardation. Imaging examinations and an endometrial biopsy revealed endometrial endometrioid carcinoma and polycystic ovary syndrome (PCOS)...
April 3, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29619209/contemporary-approaches-to-the-management-of-polycystic-ovary-syndrome
#15
REVIEW
Renato Pasquali
Polycystic ovary syndrome (PCOS) is a common disorder in women in their reproductive years and is characterized by androgen excess, ovulatory dysfunction, and polycystic ovarian morphology. It is also associated with several metabolic abnormalities, particularly insulin resistance and obesity, which play an important role in the pathophysiology of PCOS and, in particular, negatively influence ovarian function and fertility. This review article summarizes the available treatment for women with PCOS. Specifically, current and potentially new therapies are discussed...
April 2018: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29618656/ontogeny-and-reversal-of-brain-circuit-abnormalities-in-a-preclinical-model-of-pcos
#16
Mauro Sb Silva, Melanie Prescott, Rebecca E Campbell
Androgen excess is a hallmark of polycystic ovary syndrome (PCOS), a prevalent yet poorly understood endocrine disorder. Evidence from women and preclinical animal models suggests that elevated perinatal androgens can elicit PCOS onset in adulthood, implying androgen actions in both PCOS ontogeny and adult pathophysiology. Prenatally androgenized (PNA) mice exhibit a robust increase of progesterone-sensitive GABAergic inputs to gonadotropin-releasing hormone (GnRH) neurons implicated in the pathogenesis of PCOS...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29618067/local-cortisol-elevation-contributes-to-endometrial-insulin-resistance-in-polycystic-ovary-syndrome
#17
Jia Qi, Wangsheng Wang, Qinling Zhu, Yaqiong He, Yao Lu, Yuan Wang, Xiaoxue Li, Zi-Jiang Chen, Yun Sun
Context: Endometrial insulin resistance may account for the endometrial dysfunction in polycystic ovary syndrome (PCOS). The underlying mechanism remains to be elucidated. Objective: To investigate whether the abundance of 11β-hydroxysteroid dehydrogenases (11β-HSD1 and -2) and cortisol as well as the insulin signaling pathway are altered in PCOS endometrium and to clarify the relationship between endometrial insulin resistance (IR) and local cortisol. Design: We measured cortisol and cortisone concentrations, 11β-HSD1 and -2, and core insulin signaling molecules in endometrial biopsies collected from non-PCOS and PCOS with or without IR patients on day hCG+7...
March 30, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29615083/therapeutic-potentials-of-quercetin-in-management-of-polycystic-ovarian-syndrome-using-letrozole-induced-rat-model-a-histological-and-a-biochemical-study
#18
Sarwat Jahan, Abira Abid, Sidra Khalid, Tayyaba Afsar, Qurat-Ul-Ain, Ghazala Shaheen, Ali Almajwal, Suhail Razak
BACKGROUND: PCOS is a leading endocrinopathy of young women instigating androgens elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The study investigated the effects of quercetin in a letrozole induced rat model of polycystic ovarian syndrome, which displayed both clinical and metabolic features as in PCOS women. METHODS: Female Sprague Dawley (SD) rats were divided into four groups; control group received aqueous solution of carboxymethyl (CMC 0...
April 3, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29605710/serum-amh-levels-and-insulin-resistance-in-women-with-pcos
#19
Sezai Sahmay, Begum Aydogan Mathyk, Nigar Sofiyeva, Nil Atakul, Aslı Azemi, Tamer Erel
OBJECTIVE: To compare the serum AMH levels between women with and without insulin resistance (IR) in polycystic ovary syndrome (PCOS). STUDY DESIGN: 293 women with PCOS according to the Rotterdam criteria were enrolled into our study. Insulin resistance was diagnosed according to the Homeostatic model assessment insulin resistant (HOMA-IR) formula and the cut-off point was set to more than 2.5. Women were grouped according to the presence of insulin resistance (IR) (HOMA-IR ≥ 2...
March 22, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29604466/pon1-promoter-polymorphisms-contribute-to-pcos-susceptibility-and-phenotypic-outcomes-in-indian-women
#20
Roshan Dadachanji, Nuzhat Shaikh, Anushree Patil, Nalini Shah, Srabani Mukherjee
Polycystic ovary syndrome is a common endocrinopathy characterized by anovulatory infertility, hyperandrogenism, insulin resistance and oxidative stress, which predisposes affected women to reproductive and cardiometabolic complications in later life. We have investigated the association of PON1 promoter polymorphisms with PCOS susceptibility, PON1 activity and its related traits in Indian women. The genotypic and allelic frequency distribution of only -907G/C polymorphism in PON1 promoter showed significant difference between non-hyperandrogenic control and PCOS women, and was significantly associated with reduced susceptibility to PCOS, considering the recessive model...
March 28, 2018: Gene
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