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https://www.readbyqxmd.com/read/28653159/could-a-feeding-jejunostomy-be-integrated-into-a-standardized-preoperative-management-of-oeso-gastric-junction-adenocarcinoma
#1
Simone Manfredelli, Jean-Baptiste Delhorme, Aïna Venkatasamy, Christian Gaiddon, Cécile Brigand, Serge Rohr, Benoît Romain
PURPOSE: To evaluate the impact of a feeding jejunostomy (FJ) on the preoperative management of patients with an oesogastric adenocarcinoma (OGA). METHODS: From January 2007 to December 2014, patients with potentially resectable OGA were enrolled in a perioperative chemotherapy protocol. FJ was performed before starting perioperative treatments in patients presenting with dysphagia or with a nutritional risk index (NRI) <97.5. The patients who did not require a FJ served as a control group...
June 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28639555/ginkgo-biloba-and-lycopene-are-effective-on-cisplatin-induced-ototoxicity
#2
Erkan Esen, Fatih Özdoğan, Seren Gülşen Gürgen, Halil Erdem Özel, Serdar Başer, Selahattin Genç, Adin Selçuk
OBJECTIVE: The purpose of this study was to examine the anti-ototoxic impact of Ginkgo biloba extract and lycopene on the model of cisplatin-induced ototoxicity in rats. MATERIALS AND METHODS: Thirty-two Wistar albino rats were examined with the distortion product otoacoustic emission (DPOAE) test (MADSEN Capella2 ; GN Otometrics, ICS Medical, Chicago USA), and they were randomly divided into four groups. Group 1 (n=8) was defined as the healthy control group. Cisplatin was given intraperitoneally as single dose of 12 mg/kg to group 2 (n=8), group 3 (n=8), and group 4 (n=8)...
June 21, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28630127/deciphering-function-of-new-gonococcal-vaccine-antigens-using-phenotypic-microarrays
#3
Benjamin I Baarda, Sarah Emerson, Philip J Proteau, Aleksandra E Sikora
The function and extracellular location of cell envelope proteins make them attractive candidates for developing vaccines against bacterial diseases, including challenging, drug-resistant pathogens such as Neisseria gonorrhoeae Proteomics-driven reverse vaccinology delivered multiple gonorrhea vaccine candidates; however, the biological functions of many of them remain to be elucidated. Herein, the functions of six gonorrhea vaccine candidates - NGO2121, NGO1985, NGO2054, NGO2111, NGO1205, and NGO1344 - in cell envelope homeostasis were probed using phenotype microarrays with 1,056 conditions and a ΔbamE mutant (Δngo1780) as a reference of perturbed outer membrane integrity...
June 19, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28630084/maternal-lifestyle-and-nutritional-status-in-relation-to-pregnancy-and-infant-health-outcomes-in-western-china-protocol-for-a-prospective-cohort-study
#4
Li Tang, Xiong-Fei Pan, Andy H Lee, Colin W Binns, Chun-Xia Yang, Xin Sun
INTRODUCTION: Improving the health and nutrition of women and children is a priority for Western China, where the economy is less developed. Due to the dynamic nature of lifestyle, modern food habits and nutrition, there is a need to update our limited knowledge and understanding of maternal lifestyle and nutritional status and their impact on pregnancy and infant health outcomes. While breast milk is the preferred feeding option, infant formula use is widespread in China. It is thus necessary to examine the effects of formula consumption on growth and morbidity...
June 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/28627060/clinical-nutrition-counselling-service-in-the-veterinary-hospital-retrospective-analysis-of-equine-patients-and-nutritional-considerations
#5
D Vergnano, D Bergero, E Valle
Nutrition plays a very important role in the healthy and in the ill horse. Although research in this field clearly shows that incorrect nutritional practices may lead to severe pathologies, inappropriate feeding plans often continue to be used. A clinical nutrition counselling (CNC) service could thus be of great use to both horse owners and veterinarians. The aim of this study was to provide information on equine patients referred to the CNC service of the University of Turin and to provide standard dietary protocols as used in our Veterinary Teaching Hospital for the most common nutrition-related pathologies...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28609327/fluoxetine-induces-paradoxical-effects-in-c57bl6-j-mice-comparison-with-balb-c-mice
#6
Thomas Gosselin, Anne-Marie Le Guisquet, Bruno Brizard, Caroline Hommet, Frédéric Minier, Catherine Belzung
The C57BL6/J mouse is the most commonly used strain in genetic investigations and behavioural tests. However, only a few studies have used C57BL6/J mice to assess the effects of antidepressant compounds. We carried out a study to compare the behavioural effects of fluoxetine (FLX) in a model of depression in two mice strains: C57BL6/J and BALB/c. We used an 8-week unpredictable chronic mild stress (UCMS) protocol during which FLX was administered (15 mg/kg, oral) from the third week to the end of the protocol...
June 12, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28609213/aspergillus-spp-prevalence-in-different-portuguese-occupational-environments-what-is-the-real-scenario-in-high-load-settings
#7
Carla Viegas, Tiago Faria, Liliana Aranha Caetano, Elisabete Carolino, Anita Quintal Gomes, Susana Viegas
The genus Aspergillus is one of the most prevalent regarding fungi in several highly contaminated occupational environments. The goal of the current study was to assess the prevalence of Aspergillus spp. in different settings, focusing on those where a higher load of fungal contamination is expected according to the European Agency for Safety and Health at Work. A specific protocol to ensure a more accurate assessment of the exposure to Aspergillus spp. is proposed aimed at allowing a detailed risk characterization and management...
June 13, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28601157/protein-based-flushing-related-blood-urea-nitrogen-effects-on-ovarian-response-embryo-recovery-and-embryo-quality-in-superovulated-ewes
#8
İrfan Tur, Dursun Ali Dínç, Ahmet Semacan
The present study is the first report that evaluates effects of nutritional effects of flushing with differing diet crude protein ratios on blood urea nitrogen (BUN) levels, related some reproductive parameters and embryo quality in ewe. During mating season, before synchronization protocol ewes were fed on alfalfa hay and additive concentrate feeding as flushing. Intra vaginal FGA containing sponges applied for 12 days for the purpose of synchronization and pFSH was administered by 8 declining doses for the purpose of superovulation...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28597390/effects-of-nanoparticles-in-species-of-aquaculture-interest
#9
Kheyrollah Khosravi-Katuli, Ermelinda Prato, Giusy Lofrano, Marco Guida, Gonçalo Vale, Giovanni Libralato
Recently, it was observed that there is an increasing application of nanoparticles (NPs) in aquaculture. Manufacturers are trying to use nano-based tools to remove the barriers about waterborne food, growth, reproduction, and culturing of species, their health, and water treatment in order to increase aquaculture production rates, being the safe-by-design approach still unapplied. We reviewed the applications of NPs in aquaculture evidencing that the way NPs are applied can be very different: some are direclty added to feed, other to water media or in aquaculture facilities...
June 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28586401/3d-printing-and-milling-a-real-time-pcr-device-for-infectious-disease-diagnostics
#10
Geoffrey Mulberry, Kevin A White, Manjusha Vaidya, Kiminobu Sugaya, Brian N Kim
Diagnosing infectious diseases using quantitative polymerase chain reaction (qPCR) offers a conclusive result in determining the infection, the strain or type of pathogen, and the level of infection. However, due to the high-cost instrumentation involved and the complexity in maintenance, it is rarely used in the field to make a quick turnaround diagnosis. In order to provide a higher level of accessibility than current qPCR devices, a set of 3D manufacturing methods is explored as a possible option to fabricate a low-cost and portable qPCR device...
2017: PloS One
https://www.readbyqxmd.com/read/28585544/serotonin-modulates-a-depression-like-state-in-drosophila-responsive-to-lithium-treatment
#11
Ariane-Saskia Ries, Tim Hermanns, Burkhard Poeck, Roland Strauss
Major depressive disorder (MDD) affects millions of patients; however, the pathophysiology is poorly understood. Rodent models have been developed using chronic mild stress or unavoidable punishment (learned helplessness) to induce features of depression, like general inactivity and anhedonia. Here we report a three-day vibration-stress protocol for Drosophila that reduces voluntary behavioural activity. As in many MDD patients, lithium-chloride treatment can suppress this depression-like state in flies. The behavioural changes correlate with reduced serotonin (5-HT) release at the mushroom body (MB) and can be relieved by feeding the antidepressant 5-hydroxy-L-tryptophan or sucrose, which results in elevated 5-HT levels in the brain...
June 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28580621/functional-outcomes-of-fasciocutaneous-free-flap-and-pectoralis-major-flap-for-salvage-total-laryngectomy
#12
Sally Nguyen, François Thuot
BACKGROUND: Pectoralis major muscle flaps (PMMFs) and fasciocutaneous free flaps (FFFs) are commonly used for reconstruction of the surgical defect after salvage total laryngectomy. This study compared swallowing function in patients who underwent reconstruction with either PMMF or FFF. METHODS: This study was based on a retrospective cohort of patients treated at the CHU de Québec between January 2000 and March 2015. Demographics, chemoradiation data, surgical protocol, pathologic results, complications, evolution, esophageal dilation, diet intake, and feeding tube dependence were documented...
June 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28578930/meal-timing-regulates-the-human-circadian-system
#13
Sophie M T Wehrens, Skevoulla Christou, Cheryl Isherwood, Benita Middleton, Michelle A Gibbs, Simon N Archer, Debra J Skene, Jonathan D Johnston
Circadian rhythms, metabolism, and nutrition are intimately linked [1, 2], although effects of meal timing on the human circadian system are poorly understood. We investigated the effect of a 5-hr delay in meals on markers of the human master clock and multiple peripheral circadian rhythms. Ten healthy young men undertook a 13-day laboratory protocol. Three meals (breakfast, lunch, dinner) were given at 5-hr intervals, beginning either 0.5 (early) or 5.5 (late) hr after wake. Participants were acclimated to early meals and then switched to late meals for 6 days...
June 19, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28573134/high-fat-and-fat-enriched-diets-impair-the-benefits-of-moderate-physical-training-in-the-aorta-and-the-heart-in-rats
#14
Cleverson Rodrigues Fernandes, Vinicius Kannen, Karina Magalhães Mata, Fernando Tadeu Frajacomo, Alceu Afonso Jordão Junior, Bianca Gasparotto, Juliana Yumi Sakita, Jorge Elias Junior, Daphne Santoro Leonardi, Fernando Marum Mauad, Simone Gusmão Ramos, Sergio Akira Uyemura, Sergio Britto Garcia
AIM: Millions of people die each year due to cardiovascular disease (CVD). A Western lifestyle not only fuses a significant intake of fat with physical inactivity and obesity but also promotes CVD. Recent evidence suggests that dietary fat intake impairs the benefits of physical training. We investigated whether aerobic training could reverse the adverse effects of a high-fat diet (HFD) on the aorta. Then, we explored whether this type of exercise could reverse the damage to the heart that is imposed by fat-enriched diet (FED)...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28567525/forensic-entomotoxicology-revisited-towards-professional-standardisation-of-study-designs
#15
REVIEW
Erica I T da Silva, Brendan Wilhelmi, Martin H Villet
Forensic entomotoxicology is the use of insects as evidence of whether a toxicant is present in an environment such as a corpse, river or landscape. The earliest overtly forensic study was published in 1977, and since then, at least 63 papers have been published, most of them focused on the detection of toxicants in insects or on effects of toxicants on diverse insect indicator taxa. A comprehensive review of the published literature revealed various inconsistencies between studies that could be addressed by introducing standard protocols for such studies...
May 31, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28566305/tissue-specific-seasonal-changes-in-mitochondrial-function-of-a-mammalian-hibernator
#16
Ashley B Heim, Dillon J Chung, Gregory L Florant, Adam J Chicco
Mammalian hibernators, such as golden-mantled ground squirrels (Callospermophilus lateralis; GMGS), cease to feed while reducing metabolic rate and body temperature during winter months, surviving exclusively on endogenous fuels stored prior to hibernation. We hypothesized that mitochondria, the cellular sites of oxidative metabolism, undergo tissue-specific seasonal adjustments in carbohydrate and fatty acid utilization to facilitate or compliment this remarkable phenotype. To address this, we performed high-resolution respirometry of mitochondria isolated from GMGS liver, heart, skeletal muscle, and brown adipose tissue (BAT) sampled during summer (active), fall (prehibernation), and winter (hibernation) seasons using multi-substrate titration protocols...
May 31, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28566122/necrotizing-enterocolitis-classification-and-two-initial-steps-towards-prevention
#17
Sandra Meinich Juhl
The premature infant suffers from immaturity of all organ systems, one of them being the gastrointestinal tract. When the infant is born, the immature gastrointestinal tract is exposed to milk and simultaneously colonized by high densities of bacteria. The combination of milk, microbiota and an immature gut, leaves the infant vulnerable to developing the dreaded intestinal emergency necrotizing enterocolitis (NEC). NEC is often very aggressive and no cure exists, which means that prevention is an utmost important topic to researchers, physicians, parents - and infants...
June 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28551190/clinical-trial-of-local-anesthetic-protocols-for-acute-pain-associated-with-caustic-paste-disbudding-in-dairy-calves
#18
Charlotte B Winder, Stephen J LeBlanc, Derek B Haley, Kerry D Lissemore, M Ann Godkin, Todd F Duffield
Caustic paste disbudding is becoming more commonplace in North America. A large body of work has examined pain control for cautery disbudding and surgical dehorning, but fewer studies have evaluated pain control for caustic paste disbudding, and results conflict regarding benefits of local anesthesia. In humans, the pain associated with a caustic, chemical burn can differ in nature, duration, and intensity compared with a thermal burn. The objective of this clinical trial was to evaluate the effects of either a lidocaine cornual nerve block or a topical anesthetic incorporated into caustic paste on the acute pain of caustic paste disbudding...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28550982/early-provision-of-oropharyngeal-colostrum-leads-to-sustained-breast-milk-feedings-in-preterm-infants
#19
Ruth Snyder, Aimee Herdt, Nancy Mejias-Cepeda, John Ladino, Kathryn Crowley, Philip Levy
BACKGROUND: Oropharyngeal colostrum (OC) application strategies have been shown to be feasible and safe for very low birth weight (VLBW) infants. Evidence to support the nutritional and clinical advantages of OC care remains somewhat theoretical. The objectives of this study were to a) confirm the feasibility and safety of OC application in preterm infants and b) determine if OC application is associated with improved nutritional and clinical outcomes from birth to discharge. We hypothesized that OC application in the first few days would promote sustained breast milk feedings through discharge...
May 10, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28550007/associations-between-maternal-depressive-symptoms-and-nonresponsive-feeding-styles-and-practices-in-mothers-of-young-children-a-systematic-review
#20
Ana Cristina Lindsay, Tatiana Mesa, Mary L Greaney, Sherrie F Wallington, Julie A Wright
BACKGROUND: Childhood obesity is a significant global public health problem due to increasing rates worldwide. Growing evidence suggests that nonresponsive parental feeding styles and practices are important influences on children's eating behaviors and weight status, especially during early childhood. Therefore, understanding parental factors that may influence nonresponsive parental feeding styles and practices is significant for the development of interventions to prevent childhood obesity...
May 26, 2017: JMIR Public Health and Surveillance
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