Jiayi Li, Saige Yin, Ziqi Wei, Zhaoxun Xiao, Zijian Kang, Yutong Wu, Yubing Huang, Qiuye Jia, Ying Peng, Zeqiong Ru, Xiaohan Sun, Yuliu Yang, Qian Yang, Junyuan Wang, Chengxing Liu, Meifeng Yang, Ying Wang, Xinwang Yang
Melasma is a common skin disease induced by an increase in the content of melanin in the skin, which also causes serious physical and mental harm to patients. In this research, a novel peptide (Nigrocin-OA27) from Odorrana andersonii is shown to exert a whitening effect on C57 mice pigmentation model. The peptide also demonstrated non-toxic and antioxidant capacity, and can significantly reduce melanin content in B16 cells. Topical application effectively delivered Nigrocin-OA27 to skin's epidermal and dermal layers and exhibited significant preventive and whitening effects on the UVB-induced ear pigmentation model in C57 mice...
April 10, 2024: Peptides