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Triterpenoids

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https://www.readbyqxmd.com/read/28525367/liposomal-co-delivered-oleanolic-acid-attenuates-doxorubicin-induced-multi-organ-toxicity-in-hepatocellular-carcinoma
#1
Muhammad Sarfraz, Attia Afzal, Shahid Masood Raza, Sajid Bashir, Asadullah Madni, Muhammad Waseem Khan, Xiang Ma, Guangya Xiang
Doxorubicin in combination with other cytotoxic drugs has clinical advantages. However, doxorubicin-induced cardiotoxicity negatively impacts clinical utility and outcomes. Cardiotoxicity can result from increased oxidative stress or from a local cytochrome P450 mediated increase in 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE). Oleanolic acid (OA) is a natural pentacyclic triterpenoid with free radical scavenging, cardioprotective, and P450-mediated cyclooxygenase-upregulating properties. We investigated co-delivery of liposomal OA and doxorubicin in a HepG2 model of hepatocellular carcinoma (HCC)...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512854/mogroside-iiie-attenuates-lps-induced-acute-lung-injury-in-mice-partly-through-regulation-of-the-tlr4-mapk-nf-%C3%AE%C2%BAb-axis-via-ampk-activation
#2
Lijun Tao, Fengyan Cao, Gonghao Xu, Haifeng Xie, Mian Zhang, Chaofeng Zhang
Acute lung injury (ALI) often leads to high mortality, and there is as yet no effective drug treatment. The present study aimed to investigate protective effects of mogroside IIIE (MGIIIE, a cucurbitane-type triterpenoid from Siraitia grosvenorii Fruits) in experimental ALI and its underlying mechanism. MGIIIE (1, 10 0r 20 mg/kg) was orally administered for 1 h before a single intratracheal administration of lipopolysaccharide (LPS, 5 mg/kg). MGIIIE treatment dose-dependently suppressed pulmonary oedema, pro-inflammatory mediators (IL-1β, IL-6, TNF-α and HMGB1) release and higher MPO activity in lung tissues induced by LPS challenge...
May 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28511908/potential-anti-gout-constituents-as-xanthine-oxidase-inhibitor-from-the-fruits-of-stauntonia-brachyanthera
#3
Dan Liu, Dandan Wang, Wei Yang, Dali Meng
With the aim of finding a better xanthine oxidase inhibitor with potential anti-gout properties, the studies on the fruit of Stauntonia brachyanthera were carried out, which led to the isolation of 12 glycosides, including 4 new nor-oleanane triterpenoids. Their structures were determined by comprehensive spectroscopic (NMR and HR MS) analysis. Two compounds (4 and 11) exhibited significant inhibitory activities on xanthine oxidase with IC50 values of 5.22 and 1.60µM, respectively. Another five compounds (1, 2, 3, 8 and 10) showed qualified activities...
May 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28509379/microbial-eukaryotes-that-lack-sterols
#4
Kiyotaka Takishita, Yoshito Chikaraishi, Goro Tanifuji, Naohiko Ohkouchi, Tetsuo Hashimoto, Katsunori Fujikura, Andrew J Roger
It is widely held that sterols are key cyclic triterpenoid lipids in eukaryotic cell membranes and are synthesized through oxygen-dependent multi-enzyme pathways. However, there are known exceptions-ciliated protozoans, such as Tetrahymena, along with diverse low-oxygen adapted eukaryotes produce, instead of sterols, the cyclic triterpenoid lipid tetrahymanol that does not require molecular oxygen for its biosynthesis. Here, we report that a number of anaerobic microbial eukaryotes (protists) utilize neither sterols nor tetrahymanol in their membranes...
May 16, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28507119/regulation-of-the-sperm-calcium-channel-catsper-by-endogenous-steroids-and-plant-triterpenoids
#5
Nadja Mannowetz, Melissa R Miller, Polina V Lishko
The calcium channel of sperm (CatSper) is essential for sperm hyperactivated motility and fertility. The steroid hormone progesterone activates CatSper of human sperm via binding to the serine hydrolase ABHD2. However, steroid specificity of ABHD2 has not been evaluated. Here, we explored whether steroid hormones to which human spermatozoa are exposed in the male and female genital tract influence CatSper activation via modulation of ABHD2. The results show that testosterone, estrogen, and hydrocortisone did not alter basal CatSper currents, whereas the neurosteroid pregnenolone sulfate exerted similar effects as progesterone, likely binding to the same site...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28506899/hepatoprotective-activities-of-antrodia-camphorata-and-its-triterpenoid-compounds-against-ccl4-induced-liver-injury-in-mice
#6
Zi-Wei Li, Yi Kuang, Shu-Nan Tang, Kai Li, Yun Huang, Xue Qiao, Si-Wang Yu, Yew-Min Tzeng, Jen-Yu Lo, Min Ye
ETHNOPHARMACOLOGY RELEVANCE: Antrodia camphorata (AC) is a rare and precious fungus indigenous to Taiwan used as a traditional medicine for the treatment of liver injury. Triterpenoids are the major bioactive constituents of A. camphorata and have been reported to possess hepatoprotective activities. To meet the increasing demand, artificial cultivation techniques have been developed. AIM OF THE STUDY: This study aims to evaluate the hepatoprotective activities of AC samples derived from different cultivation techniques and to dissect the main active triterpenoid compounds...
May 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28506699/cra-crosolic-acid-isolated-from-actinidia-valvata-dunn-radix-induces-apoptosis-of-human-gastric-cancer-cell-line-bgc823-in%C3%A2-vitro-via-down-regulation-of-the-nf-%C3%AE%C2%BAb-pathway
#7
Qi-Lai Cheng, Hong-Liang Li, Ying-Chen Li, Zhao-Wen Liu, Xiao-Hua Guo, Yi-Jian Cheng
A natural ursolic compound, 2α,3β-dihydroxy-urs-12-en-28-oic acid (corosolic acid, CRA) was isolated from the root of Actinidia valvata Dunn. (A. valvata Radix). Since a large number of triterpenoid compound has marked anticancer effects toward various types of cancer cell lines in vitro, this study was carried out to investigate the anticancer effect of CRA in human gastric cancer cell line BGC823 cells and the underlying apoptotic mechanism of CRA was examined in BGC823 cell lines. The results showed that CRA significantly suppressed the viability of BGC823 cells in a concentration- and time-dependent manner...
May 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28504879/antitubercular-activity-of-mycelium-associated-ganoderma-lanostanoids
#8
Masahiko Isaka, Panida Chinthanom, Malipan Sappan, Sumalee Supothina, Vanicha Vichai, Kannawat Danwisetkanjana, Thitiya Boonpratuang, Kevin D Hyde, Rattaket Choeyklin
In a continuation of our research into antitubercular lanostane triterpenoids from submerged cultures of Ganoderma species, three strains, Ganoderma orbiforme BCC 22325, Ganoderma sp. BCC 60695, and Ganoderma australe BCC 22314, have been investigated. Fourteen new lanostane triterpenoids, together with 35 known compounds, were isolated. Antitubercular activities of these mycelium-associated Ganoderma lanostanoids against Mycobacterium tuberculosis H37Ra were evaluated. Taken together with the assay data of previously isolated compounds, structure-activity relationships of the antitubercular activity are proposed...
May 15, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28503180/transcriptomic-comparison-reveals-candidate-genes-for-triterpenoid-biosynthesis-in-two-closely-related-ilex-species
#9
Lingling Wen, Xiaoyun Yun, Xiasheng Zheng, Hui Xu, Ruoting Zhan, Weiwen Chen, Yaping Xu, Ye Chen, Jie Zhang
Native to Southern China, Ilex pubescens and Ilex asprella are frequently used in traditional Chinese medicine. Both of them produce a large variety of ursane-type triterpenoid saponins, which have been demonstrated to have different pharmacological effects. However, little is known about their biosynthesis. In this study, transcriptomic analysis of I. pubescens and comparison with its closely related specie I. asprella were carried out to identify potential genes involved in triterpenoid saponin biosynthesis...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28497306/triterpenoid-saponins-from-polaskia-chichipe-backbg-and-their-inhibitory-or-promotional-effects-on-the-melanogenesis-of-b16-melanoma-cells
#10
Koji Fujihara, Kunio Takahashi, Kiyotaka Koyama, Kaoru Kinoshita
Five new oleanane-type saponins 1-5 together with a known saponin 6 and a steroidal glycoside 7 were isolated from Polaskia chichipe Backbg., and their structures were determined from their 1D and 2D NMR and HRFABMS spectral data. The six isolated saponins 1-6 were tested for their effects on the melanogenesis of B16 melanoma 4A5 cells. Compound 1 exerted an inhibitory effect at 100 μM whereas compound 3 promoted melanogenesis at the same concentration, even though these two compounds contain the same aglycon structure...
May 11, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28492484/the-potential-of-triterpenoids-from-loquat-leaves-eriobotrya-japonica-for-prevention-and-treatment-of-skin-disorder
#11
Hui Tan, Tamrakar Sonam, Kuniyoshi Shimizu
The leaves of loquat (Eriobotrya japonica) possess high medicinal value and have been used as traditional medicines. However, there are no evidence-based studies on the skin-care effects of E. japonica leaves. To explore new biological activities of E. japonica leaves against skin disorder and to gain a better understanding of the chemical components associated with bioactivities, we evaluated 18 triterpenoids from E. japonica leaves on anti-melanogenesis, anti-acne, anti-allergy and anti-aging activities. Our results revealed that eight compounds showed anti-melanogenesis activity, of which ursolic acid (1) and maslinic acid (7) were the most potent with the similar selective index to that of arbutin...
May 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28490750/dv21-decreases-excitability-of-cortical-pyramidal-neurons-and-acts-in-epilepsy
#12
Min Xu, Peng Sun, Ying Zhang, Ci-Hang Yang, Xin Wei, Xiao-Xia Ma, Chong-Ren Yang, Kun-Ming Ni, Ying-Jun Zhang, Xiao-Ming Li
Epilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment. Although there are more than 15 AEDs available, a third of epilepsy patients remain refractory to available drugs, so novel effective drugs are needed. Here, we found that DV21, which is a natural triterpenoid compound extracted from plants of the Asclepiadaceae family, significantly decreased the incidence and stages of seizures in three classical drug-induced acute seizure models in C57BL/6 mice...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490237/phytochemistry-and-pharmacological-activities-of-the-genus-swertia-gentianaceae-a-review
#13
Jie Li, Yan-Li Zhao, Heng-Yu Huang, Yuan-Zhong Wang
Swertia plants have been considered to be medicinal plants useful for the treatment of various ailments for thousands of years, especially in Asian countries. This is due to the broad variety of chemical compounds that provide multiple ligands for bonding to different endogenous biomacromolecules for patients. Chemical constituents and pharmacological activities of Swertia plants are summarized in this paper. Approximately 419 metabolites and 40 bioactive compounds have been reported from 30 Swertia species, including xanthones, flavonoids, seco-iridiods, iridiods, triterpenoids, alkaloids, volatiles, and other secondary metabolites...
May 11, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28488578/triterpenoids-from-aglaia-abbreviata-exert-cytotoxicity-and-multidrug-resistant-reversal-effect-in-mcf-7-adm-cells-via-reactive-oxygen-species-induction-and-p-glycoprotein-inhibition
#14
Juan Cen, Beibei Zheng, Rubing Bai, Li Zhang, Feng Zhang, Xia Zhang
Triterpenoids from the Aglaia have been shown cytotoxicity on a broad spectrum of human tumor cells. In the present study, we extracted triterpenoids AA-5 (1) and AA-6 (2) from stems of Aglaia abbreviata, and studied their cytotoxicity in multidrug resistant (MDR) MCF-7/ADM cells. After 48 h treatment, AA-5 (1) and AA-6 (2) significantly increased mitochondrial-mediated apoptosis by enhancing reactive oxygen species (ROS) with depressed mitochondrial membrane potential and caspase-9 activities. The drug efflux transporter P-glycoprotein (P-gp) and the intracellular antioxidant systems, involving Glutathione S-Transferase π, Glutathione and heme oxygenase-1, were also inhibited via the ROS-depressed Akt/NF-E2-related factor 2 pathway...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28487997/the-effectiveness-of-anti-biofilm-and-anti-virulence-properties-of-dihydrocelastrol-and-dihydrocelastryl-diacetate-in-fighting-against-methicillin-resistant-staphylococcus-aureus
#15
Seung-Gyun Woo, So-Min Lee, So-Yeon Lee, Kyoung-Hee Lim, Eun-Ju Ha, Sa-Hyun Kim, Yong-Bin Eom
Human pathogens have readily been converted into multidrug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), because of the long-term use of conventional antibiotics. In addition, the biofilms formed by S. aureus cells are especially problematic and are related to the persistence of chronic infections because they constitute a major mechanism of promoting tolerance to diverse antimicrobial agents. Hence, the inhibitions of biofilm formation and/or toxin production are accepted as alternative means of controlling S...
May 9, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28487074/protective-effect-of-lanostane-triterpenoids-from-the-sclerotia-of-poria-cocos-wolf-against-cisplatin-induced-apoptosis-in-llc-pk1-cells
#16
Dahae Lee, Seulah Lee, Sang Hee Shim, Hae-Jeung Lee, Youkyung Choi, Tae Su Jang, Ki Hyun Kim, Ki Sung Kang
Cisplatin-induced nephrotoxicity is a serious adverse effect that limits the use of cisplatin in cancer patients. In the present study, we investigated the protective effect of lanostane triterpenoids (1-10) isolated from the ethanolic extract of Poria cocos Wolf against cisplatin-induced cell death in LLC-PK1 kidney tubular epithelial cells. Treatment of cisplatin induced significant cell death, which was suppressed by treatment with dehydroeburicoic acid monoacetate (1) and 3β-acetoxylanosta-7,9(11),24-trien-21-oic acid (9)...
April 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28482219/new-cycloartane-type-triterpenoids-from-the-areal-parts-of-caragana-sukiensis-and-their-biological-activities
#17
S Divya Reddy, Bandi Siva, V S Phani Babu, M Vijaya, V Lakshma Nayak, Reeta Mandal, Ashok K Tiwari, P Shashikala, K Suresh Babu
A comprehensive re-investigation of aerial parts of Caragana sukiensis resulted in the isolation of twelve compounds (1-12) including three new cycloartane type triterpenoids (3-5) respectively. Chemical structures of the isolated compounds were established by analysis of their IR, HRMSESI, 1D and 2D NMR spectroscopic data. In addition, these compounds were evaluated for their cytotoxic activity against cancer lines (HeLa, A549, MCF-7, DU-145) and Human embryonic kidney cell line (HEK-293). The results indicated that compound 8 showed potent cytotoxic activity against A549 with IC50 value of 1...
April 24, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28479735/cucurbitane-type-triterpenoids-from-the-blood-glucose-lowering-extracts-of-coccinia-indica-and-momordica-balsamina-fruits
#18
Ujjwal Kaushik, Vidhu Aeri, R Mir Showkat, Mohammad Ali
CONTEXT: Few vegetables that are commonly consumed in India as part of diet have been claimed for their antidiabetic potential. OBJECTIVE: The present study was aimed at evaluating preventive effects of cucurbit vegetables namely, Coccinia indica and Momordica balsamina belonging to family Cucurbitaceae in diabetic hyperglycemia. MATERIALS AND METHODS: The fruits of M. balsamina and C. indica were extracted with chloroform and fractionated with hexane to prepare an extract rich in moderately polar components...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28478866/inhibition-of-amyloid-%C3%AE-aggregation-and-protective-effect-on-sh-sy5y-cells-by-triterpenoid-saponins-from-the-cactus-polaskia-chichipe
#19
Koji Fujihara, Shin Koike, Yuki Ogasawara, Kunio Takahashi, Kiyotaka Koyama, Kaoru Kinoshita
Alzheimer's disease (AD) destroys brain function, especially in the hippocampus, and is a social problem worldwide. A major pathogenesis of AD is related to the accumulation of amyloid beta (Aβ) peptides, resulting in neuronal cell death in the brain. Here, we isolated four saponins (1-4) and elucidated their structures from 1D and 2D NMR and HRFABMS spectral data. The structures of 1 and 2 were determined as new saponins which have cochalic acid as the aglycon, and 3 was determined as a new saponin with oleanolic acid as the aglycon...
April 22, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28475371/phytochemical-constituents-and-antioxidant-activity-of-echinops-albicaulis
#20
Lashyn Kiyekbayeva, Nesma M Mohamed, Orazbekov Yerkebulan, Enas I Mohamed, Datkhayev Ubaidilla, Akhtayeva Nursulu, Mamurova Assem, Radhakrishnan Srivedavyasasri, Samir A Ross
Two thiophenes; 5-(3-buten-1-ynyl)-2,2'-bithiophene (2) and α-tertthienyl (9), two alkaloids; echinopsine (10) and echinorine (11), three flavonoids; genkwanin (5), apigenin (6), and rutin (7), two triterpenoids; lupeol acetate (1) and lupeol linoleate (4), together with 2,6,10-trimethyldodeca-2,6,10-triene (4) and β-sitosterol glucoside (8) were isolated from the aerial parts of Echinops albicaulis. Antioxidant, antimicrobial and antiprotozoal activities were evaluated. E. albicaulis aqueous methanolic extract (50, 10, and 1 mg/mL) showed significant antioxidant activity comparable to the potent antioxidant, N-acetyl cysteine, moreover, the aqueous methanolic extract (1 mg/mL) significantly reduced intracellular reactive oxygen species in active cell cultures of human peripheral blood mononuclear cells under oxidative stress more than the reference antioxidant N-acetyl cysteine...
May 5, 2017: Natural Product Research
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