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https://www.readbyqxmd.com/read/29471535/the-media-model-an-innovative-method-for-digitizing-and-training-community-members-to-facilitate-an-hiv-prevention-intervention
#1
Tiffaney Renfro, Erin Johnson, Danielle N Lambert, Gina Wingood, Ralph J DiClemente
As human immunodeficiency virus (HIV) continues to disproportionately affect African American women, practitioners remain committed to developing innovative strategies to reduce HIV prevalence. These strategies include training community organizations, such as churches, and utilizing digital media to make intervention dissemination more sustainable. This article describes one such effort to train lay community members within predominantly Black churches in Atlanta, GA, to implement an HIV prevention intervention...
February 17, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29471519/higher-risk-of-abdominal-obesity-elevated-ldl-cholesterol-and-hypertriglyceridemia-but-not-of-hypertension-in-people-living-with-hiv-results-from-the-copenhagen-comorbidity-in-hiv-infection-cocomo-study
#2
Marco Gelpi, Shoaib Afzal, Jens Lundgren, Andreas Ronit, Ashley Roen, Amanda Mocroft, Jan Gerstoft, Anne-Mette Lebech, Birgitte Lindegaard, Klaus Fuglsang Kofoed, Børge G Nordestgaard, Susanne Dam Nielsen
Background: People living with HIV (PLWH) have lower life expectancy than uninfected individuals, partly explained by excess risk of cardiovascular diseases (CVD) and CVD risk factors. We investigated the association between HIV infection and abdominal obesity, elevated LDL cholesterol (LDL-C), hypertriglyceridemia and hypertension, in a large cohort of predominantly well-treated PLWH and matched controls. Methods: 1,099 PLWH from the Copenhagen Co-morbidity in HIV infection (COCOMO) study and 12,161 age and sex-matched uninfected controls from the Copenhagen General Population Study were included and underwent blood pressure, waist-, hip-, weight-, and height-measurements...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471387/heavy-cannabis-use-associated-with-reduction-in-activated-and-inflammatory-immune-cell-frequencies-in-antiretroviral-therapy-treated-human-immunodeficiency-virus-infected-individuals
#3
Jennifer A Manuzak, Toni M Gott, Jay S Kirkwood, Ernesto Coronado, Tiffany Hensley-McBain, Charlene Miller, Ryan K Cheu, Ann C Collier, Nicholas T Funderburg, Jeffery N Martin, Michael C Wu, Nina Isoherranen, Peter W Hunt, Nichole R Klatt
Background: Cannabis is a widely used drug in the United States, and the frequency of cannabis use in the human immunodeficiency virus (HIV)-infected population is disproportionately high. Previous human and macaque studies suggest that cannabis may have an impact on plasma viral load; however, the relationship between cannabis use and HIV-associated systemic inflammation and immune activation has not been well defined. Methods: The impact of cannabis use on peripheral immune cell frequency, activation, and function was assessed in 198 HIV-infected, antiretroviral-treated individuals by flow cytometry...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471285/effects-of-docosahexanoic-acid-supplementation-on-inflammatory-and-subcutaneous-adipose-tissue-gene-expression-in-hiv-infected-patients-on-combination-antiretroviral-therapy-cart-a-sub-study-of-a-randomized-double-blind-placebo-controlled-study
#4
Pere Domingo, José Miguel Gallego-Escuredo, Irene Fernández, Joan Villarroya, Ferran Torres, María Del Mar Gutierrez, María Gracia Mateo, Francesc Villarroya, Francesc Vidal, Marta Giralt, Joan Carles Domingo
BACKGROUND: Omega-3 fatty acids have the potential to decrease inflammation and modify gene transcription. Whether docosahexanoic acid (DHA) supplementation can modify systemic inflammatory and subcutaneous adipose tissue (SAT) gene expression in HIV-infected patients is unknown. METHODS: A randomized, double-blind, placebo-controlled trial that enrolled 84 antiretroviral-treated patients who had fasting TG levels from 2.26 to 5.65 mmol/l and received DHA or placebo for 48 weeks was performed (ClinicalTrials...
February 19, 2018: Cytokine
https://www.readbyqxmd.com/read/29471092/purification-and-functional-characterization-of-recombinant-balsamin-a-ribosome-inactivating-protein-from-momordica-balsamina
#5
Parminder K Ajji, Shailendra P Sonkar, Ken Walder, Munish Puri
Balsamin, a type I ribosome-inactivating protein (RIP), has been shown to inhibit HIV-1 replication at the translation step. Our recent studies have shown that balsamin also possess anti-tumor, antibacterial and DNase-like activity, however, the amount of natural balsamin in Momordica balsamina seeds is limited and preclinical studies require large quantities of pure, bioactive balsamin. Therefore, in this study, we cloned the balsamin gene, expressed it in E. coli BL21(DE3) strain and purified it by nickel affinity chromatography...
February 19, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29470989/redox-exchange-of-the-disulfides-of-human-two-domain-cd4-regulates-the-conformational-dynamics-of-each-domain-providing-insight-into-its-mechanisms-of-control
#6
Gavin R Owen, Doris Le, Stoyan Stoychev, Nichole M Cerutti, Maria Papathanasopoulos
CD4, a membrane glycoprotein expressed by specific leukocytes, plays a vital role in the human immune response and acts as a primary receptor for HIV entry. Of its four ecto-domains (D1-D4), D1, D2, and D4 each contain a distinctive disulfide bond. Whereas the disulfides of D1 and D4 are more traditional in nature, providing structural functions, that of D2 is referred to as an "allosteric" disulfide due to its high dihedral strain energy and relative ease of reduction that is thought to regulate CD4 structure and function by shuffling its redox state...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29470985/cytoplasmic-p53-contributes-to-the-removal-of-uracils-misincorporated-by-hiv-1-reverse-transcriptase
#7
Yossi Saragani, Amnon Hizi, Galia Rahav, Sara Zauch, Mary Bakhanashvili
HIV-1 reverse transcriptase (RT) in the cytoplasm of HIV-infected cells efficiently inserts the non-canonical dUTP into the proviral DNA, and extends the dU-terminated DNA. The misincorporation of dUTP leads to mutagenesis, and uracils can down-regulate viral gene expression. However, uracilation might also protect HIV DNA from auto-integration in the cytoplasm. Tumor suppressor p53 protein, exhibiting inherent 3'→5' exonuclease activity, provides a potential host-derived repair mechanism during HIV reverse transcription for the misincorporation of various wrong nucleotides, leading to both base-base mismatches and incorporated non-canonical ribonucleotides...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29470809/receiving-hiv-serostatus-disclosure-from-partners-before-sex-results-from-an-online-survey-of-chinese-men-who-have-sex-with-men
#8
Weiming Tang, Chuncheng Liu, Bolin Cao, Stephen W Pan, Ye Zhang, Jason Ong, Hongyun Fu, Baoli Ma, Rong Fu, Bin Yang, Wei Ma, Chongyi Wei, Joseph D Tucker
HIV serostatus disclosure before sex can facilitate serosorting, condom use and potentially decrease the risk of HIV acquisition. However, few studies have evaluated HIV serostatus disclosure from partners before sex. We examined the rate and correlates of receiving HIV serostatus disclosure from regular and casual male partners before sex among an online sample of men who have sex with men (MSM) in China. An online cross-sectional study was conducted among MSM in eight Chinese cities in July 2016. Participants completed questions covering sociodemographic information, sexual behaviors, HIV testing (including HIV self-testing) history, self-reported HIV status, and post-test violence...
February 22, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29470808/comparative-analysis-of-recruitment-strategies-in-a-study-of-men-who-have-sex-with-men-msm-in-metropolitan-detroit
#9
Bradley E Iott, Tiffany C Veinot, Jimena Loveluck, Erin Kahle, Leon Golson, Akilah Benton
HIV/AIDS-related research requires recruitment of representative samples of MSM; yet, we know little about the comparative yield, diversity and cost-benefit tradeoffs between different recruitment venues. We compared 11 recruitment venues used for nine HIV prevention-related focus groups with MSM in Metropolitan Detroit. Of the 64 participants, 24 were clients recruited via an HIV/AIDS-focused nonprofit, 20 from Grindr advertisements, 6 from university-student email lists, and 5 from flyers/palmcards. Significantly more African-American, low-income and HIV-positive participants were recruited via the nonprofit...
February 22, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29470782/treatment-of-hepatitis-c-during-pregnancy-weighing-the-risks-and-benefits-in-contrast-to-hiv
#10
REVIEW
A Sidney Barritt, Ravi Jhaveri
PURPOSE OF REVIEW: Increasing hepatitis C virus (HCV) cases over the past decade have raised concerns about subsequent increased cases in infants due to mother to child transmission (MTCT). Many are reminded of the early days of HIV and the rationale for using antiretroviral agents during pregnancy. RECENT FINDINGS: Direct-acting antivirals (DAAs) that are highly potent, all-oral, short-duration regimens that cure HCV have led many to consider what it would entail to use DAAs for pregnant women...
February 22, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29470552/increased-hiv-1-transcriptional-activity-and-infectious-burden-in-peripheral-blood-and-gut-associated-cd4-t-cells-expressing-cd30
#11
Louise E Hogan, Joshua Vasquez, Kristen S Hobbs, Emily Hanhauser, Brandon Aguilar-Rodriguez, Rajaa Hussien, Cassandra Thanh, Erica A Gibson, Alexander B Carvidi, Louis C B Smith, Shahzada Khan, Martin Trapecar, Shomyseh Sanjabi, Ma Somsouk, Cheryl A Stoddart, Daniel R Kuritzkes, Steven G Deeks, Timothy J Henrich
HIV-1-infected cells persist indefinitely despite the use of combination antiretroviral therapy (ART), and novel therapeutic strategies to target and purge residual infected cells in individuals on ART are urgently needed. Here, we demonstrate that CD4+ T cell-associated HIV-1 RNA is often highly enriched in cells expressing CD30, and that cells expressing this marker considerably contribute to the total pool of transcriptionally active CD4+ lymphocytes in individuals on suppressive ART. Using in situ RNA hybridization studies, we show co-localization of CD30 with HIV-1 transcriptional activity in gut-associated lymphoid tissues...
February 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29470532/psychosocial-health-and-suicidal-ideation-among-people-living-with-hiv-aids-a-cross-sectional-study-in-nanjing-china
#12
Wei Wang, Chenchang Xiao, Xing Yao, Yinmei Yang, Hong Yan, Shiyue Li
BACKGROUND: Suicide is a serious cause of mortality worldwide and is considered as a psychiatric emergency. People living with HIV/AIDS (PLWHA) have higher rates of suicidal behavior than the general population. This study assessed the prevalence and verified the syndemic effect of psychosocial health conditions on suicidal ideation among PLWHA in China. METHODS: An institutional-based cross-sectional study was conducted from July to August 2016 in Nanjing, China, using a self-report questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29470530/effectiveness-of-health-education-intervention-in-improving-knowledge-attitude-and-practices-regarding-tuberculosis-among-hiv-patients-in-general-hospital-minna-nigeria-a-randomized-control-trial
#13
Chindo Ibrahim Bisallah, Lekhraj Rampal, Munn-Sann Lye, Sherina Mohd Sidik, Normala Ibrahim, Zubairu Iliyasu, Michael Ochigbo Onyilo
INTRODUCTION: The risk of development of active TB in HIV-infected individuals is 20-37 times higher than those that are HIV negative. Poor knowledge of TB amongst people living with HIV has been associated with high transmission. OBJECTIVES: To determine the effectiveness of a new health education intervention module in improving knowledge, attitude, and practice (KAP) regarding tuberculosis among HIV patients in General Hospital Minna, Nigeria. METHODS: A randomized control trial was carried out from July 2015 to June 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29470512/association-between-hiv-status-and-depressive-symptoms-among-children-and-adolescents-in-the-southern-highlands-zone-tanzania-a-case-control-study
#14
Abraham Lwidiko, Stephen Matthew Kibusi, Azan Nyundo, Bonaventura C T Mpondo
BACKGROUND: Children and adolescents continue to have HIV/AIDS in southern Saharan Africa. Scaling up of HIV services has significantly improved access to ARV and consequently improved on morbidity and mortality related to HIV/AIDS including opportunistic infection. Despite the above efforts, non-communicable conditions including mental disorders such as depression have been observed to contribute to the burden of disabilities about which little is documented. This study, therefore, aimed to determine the magnitude of depressive symptoms and the associated factors among HIV-infected children and adolescents...
2018: PloS One
https://www.readbyqxmd.com/read/29470508/preterm-delivery-and-small-for-gestation-outcomes-in-hiv-infected-pregnant-women-on-antiretroviral-therapy-in-rural-south-africa-results-from-a-cohort-study-2010-2015
#15
Terusha Chetty, Claire Thorne, Anna Coutsoudis
OBJECTIVES: Increasingly more women conceive on antiretroviral therapy (ART) with non-nucleoside reverse transcriptase-based regimens. This study assessed the effect of preconception tenofovir disoproxil fumarate (TDF)-lamivudine (3TC)/emtricitabine (FTC)-efavirenz (EFV) and post-conception TDF-(3TC/FTC)-EFV (versus other regimens) on preterm delivery (PTD) and small-for-gestational age (SGA) births. METHODS: We analysed data of 2549 HIV-infected women attending antenatal clinics in KwaZulu-Natal from 2010 through 2015 in this retrospective cohort study...
2018: PloS One
https://www.readbyqxmd.com/read/29470485/an-innovative-hiv-testing-service-using-the-internet-anonymous-urine-delivery-testing-service-at-drugstores-in-beijing-china
#16
Xiaoxia He, Guowu Liu, Dongyan Xia, Xia Feng, Yi Lv, Huanyi Cheng, Yuehua Wang, Hongyan Lu, Yan Jiang
Innovative human immunodeficiency virus (HIV) testing services will be needed to achieve the first 90 (90% of HIV-positive persons aware of their infection status) of the 90-90-90 target in China. Here, we describe an internet-based urine delivery testing service delivered through three pilot drugstores in Beijing that send specimens to a designated laboratory for HIV. From May 2016 to January 2017, we provided 500 HIV urine-testing service packs for display at the drugstores, and a total of 430 (86.0%) urine specimens were mailed back...
2018: PloS One
https://www.readbyqxmd.com/read/29470457/hiv-diagnoses-among-persons-aged-13-29-years-united-states-2010-2014
#17
M Cheryl Bañez Ocfemia, Richard Dunville, Tianchi Zhang, Lisa C Barrios, Alexandra M Oster
In 2014, persons aged 13-29 years represented 23% of the U.S. population, yet accounted for 40% of diagnoses of human immunodeficiency virus (HIV) infection during the same year (1). During 2010-2014, the rates of diagnosis of HIV infection decreased among persons aged 15-19 years, were stable among persons aged 20-24 years, and increased among persons aged 25-29 years (1). However, these 5-year age groups encompass multiple developmental stages and potentially mask trends associated with the rapid psychosocial changes during adolescence through young adulthood...
February 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29470200/addressing-hiv-stigma-in-health-care
#18
Mariam Davtyan, Ellen F Olshansky, Cynthia Lakon
Strategies to address this potent barrier to treatment and prevention.
March 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29469724/oral-lesions-as-an-important-marker-for-hiv-progression
#19
Paulo Henrique Braz-Silva, Juliana Lucena Schussel, Karen López Ortega, Marina Gallottini
BACKGROUND: Oral hairy leukoplakia (OHL) is a benign lesion caused by Epstein-Barr virus (EBV) replication in the oral epithelium affecting the borders of the tongue. It is strongly associated with immunosuppression, especially in HIV+ adults but is uncommon in pediatric population. The aim of the study is to show the importance of the correct diagnosis of OHL and its influence on HIV treatment.We report two cases of HIV+ adolescent patients that presented with leukoplakic lesions on the border of the tongue, suggestive of OHL...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469716/associated-conditions-in-patients-with-multiple-dermatofibromas-case-reports-and-literature-review
#20
Surget V Beatrous, Ryan R Riahi, Stratton B Grisoli, Philip R Cohen
Dermatofibromas are benign, fibrohistiocytic, dermal tumors. Solitary dermatofibromas may be incidental findings, whereas multiple dermatofibromas may be associated with systemic conditions or previous therapies. Two women and one man with multiple dermatofibromas and an associated systemic condition, immunosuppression, or both, are described. Nine dermatofibromas developed in a woman with hypothyroidism, optic neuritis, and Arnold Chiari I malformation. Five dermatofibromas developed in a woman with breast cancer who had received several systemic antineoplastic therapies...
September 22, 2017: Dermatology Online Journal
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