Ingrid G Bustos, Rosana Wiscovitch-Russo, Harinder Singh, Benjamín L Sievers, Michele Matsuoka, Marcelo Freire, Gene S Tan, Mónica P Cala, Jose L Guerrero, Ignacio Martin-Loeches, Norberto Gonzalez-Juarbe, Luis Felipe Reyes
Background Patients with COVID-19 under invasive mechanical ventilation are at higher risk of developing ventilator-associated pneumonia (VAP), associated with increased healthcare costs, and unfavorable prognosis. The underlying mechanisms of this phenomenon have not been thoroughly dissected. Therefore, this study attempted to bridge this gap by performing a lung microbiota analysis and evaluating the host immune responses that could drive the development of VAP. Materials and methods In this prospective cohort study, mechanically ventilated patients with confirmed SARS-CoV-2 infection were enrolled...
March 8, 2024: Research Square