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https://www.readbyqxmd.com/read/28538360/consort-may-stereotactic-intracavity-administration-of-antibiotics-shorten-the-course-of-systemic-antibiotic-therapy-for-brain-abscesses
#1
Xin Yu, Rui Liu, Yaming Wang, Hulin Zhao, Jinhui Chen, Jianning Zhang, Chenhao Hu
BACKGROUND: Despite advances in surgical techniques in the management of the brain abscess, continuous systemic long-term antibiotics are necessary and crucial. This study was designed to evaluate the effect of intracavity administration of high-dose antibiotics on the course of antibiotic therapy. METHODS: Between 2003 and 2013, 55 patients with bacterial brain abscesses (83 abscesses) were treated with stereotactic aspiration and intracavity injection of high-dose antibiotics combined with a short course systemic antibiotic therapy...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538157/cell-and-tissue-scale-forces-coregulate-fgfr2-dependent-tetrads-and-rosettes-in-the-mouse-embryo
#2
Jun Wen, Hirotaka Tao, Kimberly Lau, Haijiao Liu, Craig A Simmons, Yu Sun, Sevan Hopyan
What motivates animal cells to intercalate is a longstanding question that is fundamental to morphogenesis. A basic mode of cell rearrangement involves dynamic multicellular structures called tetrads and rosettes. The contribution of cell-intrinsic and tissue-scale forces to the formation and resolution of these structures remains unclear, especially in vertebrates. Here, we show that Fgfr2 regulates both the formation and resolution of tetrads and rosettes in the mouse embryo, possibly in part by spatially restricting atypical protein kinase C, a negative regulator of non-muscle myosin IIB...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28537891/multiplex-pcr-approach-to-simultaneously-identify-several-mutations-in-fine-needle-cytology-thyroid-samples
#3
Emilia Vuttariello, Marco Borra, Elvira Mauriello, Celeste Calise, Barbara D'Andrea, Anna Capiluongo, Franco Fulciniti, Anna Cipolletta, Mario Monaco, Luciano Pezzullo, Gennaro Chiappetta
The most frequent initial manifestation of thyroid cancer is the appearance of a nodule. More than 20% of the general population has a palpable thyroid nodule and the percentage rises to 70% based on ultrasound identification. In 95% of cases the nodule is simply a hyperplastic or benign lesion. The most reliable diagnostic test for thyroid nodules is fine needle aspiration (FNA), but cytological discrimination between malignant and benign follicular neoplasms remains difficult. Cytological analysis is now, almost routinely, being combined with molecular genetics to enable the pathologist to make a more objective diagnosis...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28537807/next-generation-sequencing-identifies-gene-mutations-that-are-predictive-of-malignancy-in-residual-needle-rinses-collected-from-fine-needle-aspirations-of-thyroid-nodules
#4
Maren Y Fuller, Dina Mody, April Hull, Kristi Pepper, Heather Hendrickson, Randall Olsen
CONTEXT: - Thyroid nodules have a prevalence of approximately 70% in adults. Fine-needle aspiration (FNA) is a minimally invasive, cost-effective, standard method to collect tissue from thyroid nodules for cytologic examination. However, approximately 15% of thyroid FNA specimens cannot be unambiguously diagnosed as benign or malignant. OBJECTIVE: - To investigate whether clinically actionable data can be obtained using next-generation sequencing of residual needle rinse material...
May 24, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28535578/coasting-withholding-gonadotrophins-for-preventing-ovarian-hyperstimulation-syndrome
#5
REVIEW
Arianna D'Angelo, Nazar N Amso, Rudaina Hassan
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic and potentially life threatening condition resulting from excessive ovarian stimulation. Reported incidence of moderate to severe OHSS ranges from 0.6% to 5% of in vitro fertilization (IVF) cycles. The factors contributing to OHSS have not been completely explained. The release of vasoactive substances secreted by the ovaries under human chorionic gonadotrophin (hCG) stimulation may play a key role in triggering this syndrome...
May 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28534723/evaluation-of-a-jugular-venipuncture-alpaca-model-to-teach-the-technique-of-blood-sampling-in-adult-alpacas
#6
Marjolaine Rousseau, Guy Beauchamp, Sylvain Nichols
The effectiveness of teaching aids in veterinary medical education is not often assessed rigorously. The objective in the present study was to evaluate the effectiveness of a commercially available jugular venipuncture alpaca model as a complementary tool to teach veterinary students how to perform venipuncture in adult alpacas. We hypothesized that practicing on the model would allow veterinary students to draw blood in alpacas more rapidly with fewer attempts than students without previous practice on the model...
May 23, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28534708/granulomatous-epididymo-orchitis-diagnosis-by-fine-needle-aspiration
#7
Uma Handa, Reetu Kundu, Gunjan Raghubanshi, Vidur Bhalla
Tuberculosis is the leading cause of chronic granulomatous epididymo-orchitis in the Asian population. A retrospective analysis of 40 patients diagnosed with granulomatous or tubercular epididymo-orchitis on fine-needle aspiration (FNA) was carried out. May Grünwald giemsa, haematoxylin and eosin and Ziehl Neelsen stained smears were evaluated. Of 40 patients studied, aspiration smears showed epithelioid cell granulomas with caseation in 17, granulomas alone in 19 and caseation only in four. Acid fast bacilli were seen in 15...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28534687/role-of-molecular-markers-in-thyroid-nodule-management-then-and-now
#8
Yuri E Nikiforov
OBJECTIVE: To describe the evolution and clinical utility of molecular testing for thyroid nodules and cancer achieved over the last two decades. METHODS: Scientific reports on thyroid cancer genetics and molecular diagnostics in thyroid nodules. RESULTS: Over the last two decades, our understanding of the genetic mechanisms of thyroid cancer has dramatically expanded, such that most thyroid cancers now have known gene driver events. This knowledge provides the basis for establishing and further improving molecular tests for thyroid nodules and cancer and for the introduction of new entities such as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)...
May 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28534671/silver-nitrate-aspiration-a-potentially-life-threatening-complication
#9
Stijn Bekkers, Johannes A Rijken, Johannes M A Daniels, Rico N P M Rinkel, Jan-Jaap Hendrickx, Simone E J Eerenstein
No abstract text is available yet for this article.
May 23, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28534378/secondary-malignant-tumors-of-the-parotid-gland-not-a-secondary-problem
#10
Antonio Pastore, Andrea Ciorba, Marco Soliani, Andrea Di Laora, Giorgia Valpiani, Chiara Bianchini, Francesco Stomeo, Roberto Merlo, Stefano Pelucchi
PURPOSE: To present the clinical features of patients with parotid gland metastasis, and compare the results with previously published series. Most of the relevant literature arises from case reports, while there are only few series reported, as secondary neoplastic lesions of the parotid gland are uncommon. METHODS: The medical records of patients with parotid gland metastasis, treated at the ENT Department of the University Hospital of Ferrara, between January 1st 1965 and December 31th 2014, were retrospectively reviewed...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28534344/orbital-lymphangioma-characteristics-and-treatment-outcomes-of-12-cases
#11
Young Jun Woo, Chang Yeom Kim, Bradford Sgrignoli, Jin Sook Yoon
PURPOSE: To report the patient characteristics and treatment outcomes in 12 cases of orbital lymphangioma. METHODS: In this study, orbital lymphangioma was diagnosed based on clinical, radiologic (computed tomography, magnetic resonance imaging), and histologic findings when possible. Patients whose vision was not compromised by orbital lymphangioma, or that did not have increased intraocular pressure (IOP), received oral corticosteroids. Orbital lymphangioma that affected vision or increased IOP was treated by surgery, which included aspiration of blood or partial resection with or without injection of a sclerosant...
May 12, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28534218/flexible-bronchoscopy-in-non-resolving-pneumonia
#12
Javeed Iqbal Bhat, Wasim Ahmad Wani, Qazi Iqbal Ahmad, Bashir Ahmad Charoo, Syed Wajid Ali, Ambreen Ali Ahangar, Muzafar Ahmad
OBJECTIVE: To study the utility of diagnostic flexible bronchoscopy and bronchoalveolar lavage (BAL) in children with non-resolving pneumonia. METHODS: This was a cross-sectional study conducted in a tertiary care hospital from July 2015 through June 2016. Fifty-two consecutive children of both genders from 1 mo to 14 y of age with a diagnosis of non-resolving pneumonia were included. Flexible bronchoscopy was done in all patients with or without bronchoalveolar lavage (BAL)...
May 23, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28534064/reflections-on-clinical-and-statistical-use-of-the-penetration-aspiration-scale
#13
REVIEW
Catriona M Steele, Karen Grace-Martin
The 8-point Penetration-Aspiration Scale (PAS) was introduced to the field of dysphagia in 1996 and has become the standard method used by both clinicians and researchers to describe and measure the severity of airway invasion during swallowing. In this article, we review the properties of the scale and explore what has been learned over 20 years of use regarding the construct validity, ordinality, intervality, score distribution, and sensitivity of the PAS to change. We propose that a categorical revision of the PAS into four levels of increasing physiological severity would be appropriate...
May 22, 2017: Dysphagia
https://www.readbyqxmd.com/read/28533594/effects-of-expiratory-muscle-strength-training-on-swallowing-function-in-acute-stroke-patients-with-dysphagia
#14
Jong Hoon Moon, Jin-Hwa Jung, Young Sik Won, Hwi-Young Cho, KiHun Cho
[Purpose] This study was conducted to identify the effects of expiratory muscle strength training on swallowing function in acute stroke patients with dysphagia. [Subjects and Methods] A total of 18 stroke patients with dysphagia were enrolled in the study. All participants were randomly assigned to either an experimental group (n=9) or a control group (n=9). All participants performed traditional-swallowing rehabilitation therapy in 30-minute sessions five times a week for four weeks; however, only the experimental group received expiratory muscle strength training...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533448/correction-to-predictors-of-the-aspiration-component-success-of-a-direct-aspiration-first-pass-technique-adapt-for-the-endovascular-treatment-of-stroke-reperfusion-strategy-in-anterior-circulation-acute-stroke
#15
https://www.readbyqxmd.com/read/28533360/female-peer-mentors-early-in-college-increase-women-s-positive-academic-experiences-and-retention-in-engineering
#16
Tara C Dennehy, Nilanjana Dasgupta
Scientific and engineering innovation is vital for American competitiveness, quality of life, and national security. However, too few American students, especially women, pursue these fields. Although this problem has attracted enormous attention, rigorously tested interventions outside artificial laboratory settings are quite rare. To address this gap, we conducted a longitudinal field experiment investigating the effect of peer mentoring on women's experiences and retention in engineering during college transition, assessing its impact for 1 y while mentoring was active, and an additional 1 y after mentoring had ended...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28532942/robot-assisted-simulated-cataract-surgery
#17
Tristan Bourcier, Jimmy Chammas, Pierre-Henri Becmeur, Arnaud Sauer, David Gaucher, Philippe Liverneaux, Jacques Marescaux, Didier Mutter
PURPOSE: To evaluate the feasibility of robot-assisted simulated cataract surgery. SETTING: Institut de Recherche Contre les Cancers de l'Appareil Digestif, European Institute of Telesurgery, and Strasbourg University Hospital, Strasbourg, France. DESIGN: Experimental study. METHODS: Cataract surgeries were performed on a Kitaro cataract wet-lab training system simultaneously using the Da Vinci Xi robotic surgical system and the Whitestar Signature phacoemulsification system...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28532823/effects-of-rumen-protected-methionine-and-choline-supplementation-on-steroidogenic-potential-of-the-first-postpartum-dominant-follicle-and-expression-of-immune-mediators-in-holstein-cows
#18
D A V Acosta, M I Rivelli, C Skenandore, Z Zhou, D H Keisler, D Luchini, M N Corrêa, F C Cardoso
Multiparous Holstein cows were assigned in a randomized complete block design into four treatments from 21 d before calving to 30 d in milk (DIM). Treatments were: MET [n = 19, fed the basal diet + rumen-protected methionine at a rate of 0.08% (w/w) of the dry matter, Smartamine(®) M], CHO (n = 17, fed the basal diet + choline 60 g/d, Reashure(®)), MIX (n = 21, fed the basal diet + Smartamine(®) M at a rate of 0.08% (w/w) of the dry matter and 60 g/d Reashure(®)), and CON (n = 20, no supplementation, fed the close-up and fresh cow diets)...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28532209/master-s-degrees-meeting-the-standards-for-medical-and-health-professions-education
#19
Ara S Tekian, David C M Taylor
Increasing numbers of educators are finding it necessary to obtain advanced training in medical and health professions education. This demand has been met by a wide variety of postgraduate courses. In this Guide, we present an international consensus statement of the standards to which Master's courses in medical and health professions education should aspire.
May 22, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28531883/conventional-versus-ultrasound-guided-transbronchial-needle-aspiration-for-the-diagnosis-of-hilar-mediastinal-lymph-adenopathies-a-randomized-controlled-trial
#20
Martina Bonifazi, Irene Tramacere, Lina Zuccatosta, Federico Mei, Michele Sediari, Maria Cristina Paonessa, Stefano Gasparini
BACKGROUND: Conventional transbronchial needle aspiration (c-TBNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are both valuable diagnostic techniques for the diagnosis of hilar/mediastinal lesions. Although a superiority of EBUS-TBNA over c-TBNA may be expected, evidence-based data on a direct comparison between these 2 procedures are still lacking. OBJECTIVES: We aimed to test the superiority of EBUS-TBNA over c-TBNA in a randomized trial and to evaluate the cost-effectiveness profile of a staged strategy, including c-TBNA as initial test followed by EBUS-TBNA, in case of inconclusive results at rapid on-site evaluation...
May 23, 2017: Respiration; International Review of Thoracic Diseases
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