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https://www.readbyqxmd.com/read/28829938/fluoride-ion-release-of-self-adhesive-resin-cements-and-their-potential-to-inhibit-in-situ-enamel-and-dentin-demineralization
#1
V A Pellizzari, A C Michels, S T Luiz, E M de Souza, Cpm Tabchoury, R N Rached
OBJECTIVE: This study evaluated in situ the potential of a glass ionomer and self-adhesive resin cements to inhibit enamel and dentin demineralization around indirect restorations exposed to cariogenic challenge. The cumulative fluoride release (CFR) of materials was measured in water and acid. METHODS: Seventy blocks cut from human molars received two indirect composite restorations (one in enamel and another in dentin) luted with Ketac Cem EasyMix (GIC, positive control), SeT (SeT), Maxcem Elite (Max), Smart Cem2 (Smart), and RelyX Unicem 2 (Unicem2)...
September 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28829898/internal-amplification-control-of-pcr-for-the-glu1-dx5-allele-in-wheat
#2
H N Heim, E S N Vieira, L R T Polo, N K Lima, G J Silva, G A Linde, N B Colauto, I Schuster
One of the limiting factors in using dominant markers is the unique amplification of the target fragment. Therefore, failures in polymerase chain reaction (PCR) or non-amplifications can be interpreted as an absence of the allele. The possibility of false negatives implies in reduced efficiency in the selection process in genetic breeding programs besides the loss of valuable genetic material. Thus, this study aimed to evaluate the viability of a microsatellite marker as an internal amplification control with a dominant marker for the wheat Glu1-Dx5 gene...
August 17, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28829896/analysis-of-mendelian-inheritance-and-genetic-linkage-in-microsatellite-loci-of-eucalyptus-urophylla-s-t-blake
#3
S Pupin, L N Rosse, I C G Souza, J Cambuim, C L Marino, M L T Moraes, A M Sebbenn
Eucalyptus urophylla is an important species in the Brazilian forest sector due to its rapid growth rates and resistance to disease. The aim of this study was to verify Mendelian inheritance, genetic linkage, and genotypic disequilibrium for 15 microsatellite loci, with the goal of producing a robust set of genetic markers. Mendelian inheritance and genetic linkage analyses were carried out using genotypes from maternal trees, and their open-pollinated seeds and genotypic disequilibrium were assessed using adult trees...
August 17, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28829889/stability-of-annual-biomass-energy-production-of-elephant-grass-pennisetum-purpureum-schum-genotypes-in-the-northern-region-of-the-rio-de-janeiro-state-brazil
#4
M S B Araújo, R F Daher, B R S Menezes, G A Gravina, V B Silva, A T Amaral Júnior, E V Rodrigues, B O Almeida, N J Ponciano
The objectives of this study were to estimate the stability of dry biomass production of elephant grass genotypes under an annual harvest regime, in soil-climatic conditions of the Northern region of the Rio de Janeiro State, Brazil, and to compare methodologies for stability analyses of Yates and Cochran (YC), Plaisted and Peterson (PP), Annicchiarico (ANN), Lin and Binns (LB), Huenh (HU), and Kang and Phan (KP). A randomized block design with 83 treatments and two replicates was adopted. Four annual harvests were performed (2012-2015) and dry matter yield (DMY, t...
August 17, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28829884/effect-of-oral-prednisolone-on-symptom-duration-and-severity-in-nonasthmatic-adults-with-acute-lower-respiratory-tract-infection-a-randomized-clinical-trial
#5
Alastair D Hay, Paul Little, Anthony Harnden, Matthew Thompson, Kay Wang, Denise Kendrick, Elizabeth Orton, Sara T Brookes, Grace J Young, Margaret May, Sandra Hollinghurst, Fran E Carroll, Harriet Downing, David Timmins, Natasher Lafond, Magdy El-Gohary, Michael Moore
Importance: Acute lower respiratory tract infection is common and often treated inappropriately in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient evidence. Objective: To assess the effects of oral corticosteroids for acute lower respiratory tract infection in adults without asthma. Design, Setting, and Participants: Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2014) conducted in 54 family practices in England among 401 adults with acute cough and at least 1 lower respiratory tract symptom not requiring immediate antibiotic treatment and with no history of chronic pulmonary disease or use of asthma medication in the past 5 years...
August 22, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28829492/metformin-increases-norepinephrine-transporter-expression-in-placenta-of-patients-with-polycystic-ovary-syndrome
#6
G Medina, M Maliqueo, N Crisosto, B Echiburú, T Sir-Petermann, H E Lara
OBJECTIVE: To evaluate the norepinephrine (NE) and placental NE transporter (NET) in women with polycystic ovary syndrome (PCOS) non-treated and treated with metformin during pregnancy. PATIENTS AND METHODS: We studied sixteen pregnant women with PCOS: 8 without metformin treatment during pregnancy (PCOS-M) and 8 treated with metformin during pregnancy (PCOS+M). Sixteen pregnant women of similar age without PCOS were included as controls (Control). At 24th and 35th weeks of pregnancy, blood samples were obtained...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28829391/a-rare-form-of-retinal-dystrophy-caused-by-hypomorphic-nonsense-mutations-in-cep290
#7
Susanne Roosing, Frans P M Cremers, Frans C C Riemslag, Marijke N Zonneveld-Vrieling, Herman E Talsma, Francoise J M Klessens-Godfroy, Anneke I den Hollander, L Ingeborgh van den Born
PURPOSE: To identify the gene defect and to study the clinical characteristics and natural course of disease in a family originally diagnosed with oligocone trichromacy (OT), a rare congenital cone dysfunction syndrome. METHODS: Extensive clinical and ophthalmologic assessment was performed on two siblings with OT and long-term follow up data were analyzed. Subsequently, whole exome sequencing (WES) and Sanger sequence analysis of CEP290 was performed in the two siblings...
August 22, 2017: Genes
https://www.readbyqxmd.com/read/28829000/diversity-and-host-specificity-of-monogenean-gill-parasites-platyhelminthes-of-cichlid-fishes-in-the-bangweulu-mweru-ecoregion
#8
M W P Jorissen, A Pariselle, T Huyse, E J Vreven, J Snoeks, F A M Volckaert, A Chocha Manda, G Kapepula Kasembele, T Artois, M P M Vanhove
This study represents the first exploration of the parasite fauna of cichlid fishes in the Mweru-Luapula subregion (Central Africa). Twelve species of cichlids and 14 species of Monogenea from three genera (Cichlidogyrus, Gyrodactylus and Scutogyrus) were collected. We present a first record of the gill parasite fauna of eight host species, Oreochromis mweruensis, Orthochromis sp. 'Mambilima', Sargochromis mellandi, Serranochromis angusticeps, S. stappersi, S. thumbergi and Tylochromis mylodon. The host range of ten parasite species was expanded...
August 22, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28828698/prediction-of-new-brain-metastases-after-radiosurgery-validation-and-analysis-of-performance-of-a-multi-institutional-nomogram
#9
Diandra N Ayala-Peacock, Albert Attia, Steve E Braunstein, Manmeet S Ahluwalia, Jaroslaw Hepel, Caroline Chung, Joseph Contessa, Emory McTyre, Ann M Peiffer, John T Lucas, Scott Isom, Nicholas M Pajewski, Rupesh Kotecha, Mark J Stavas, Brandi R Page, Lawrence Kleinberg, Colette Shen, Robert B Taylor, Nasarachi E Onyeuku, Andrew T Hyde, Daniel Gorovets, Samuel T Chao, Christopher Corso, Jimmy Ruiz, Kounosuke Watabe, Stephen B Tatter, Gelareh Zadeh, Veronica L S Chiang, John B Fiveash, Michael D Chan
Stereotactic radiosurgery (SRS) without whole brain radiotherapy (WBRT) for brain metastases can avoid WBRT toxicities, but with risk of subsequent distant brain failure (DBF). Sole use of number of metastases to triage patients may be an unrefined method. Data on 1354 patients treated with SRS monotherapy from 2000 to 2013 for new brain metastases was collected across eight academic centers. The cohort was divided into training and validation datasets and a prognostic model was developed for time to DBF. We then evaluated the discrimination and calibration of the model within the validation dataset, and confirmed its performance with an independent contemporary cohort...
August 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28827983/genotypic-and-phenotypic-evaluation-of-off-type-grasses-in-hybrid-bermudagrass-cynodon-dactylon-l-pers-x-c-transvaalensis-burtt-davy-putting-greens-using-genotyping-by-sequencing-and-morphological-characterization
#10
Eric H Reasor, James T Brosnan, Margaret E Staton, Thomas Lane, Robert N Trigiano, Phillip A Wadl, Joann A Conner, Brian M Schwartz
BACKGROUND: Interspecific hybrid bermudagrass [Cynodon dactylon (L.) Pers. x C. transvaalensis Burtt-Davy] is one of the most widely used grasses on golf courses, with cultivars derived from 'Tifgreen' or 'Tifdwarf' particularly used for putting greens. Many bermudagrass cultivars established for putting greens can be genetically unstable and lead to the occurrence of undesirable off-type grasses that vary in phenotype. The objective of this research was to genetically and phenotypically differentiate off-type grasses and hybrid cultivars...
2018: Hereditas
https://www.readbyqxmd.com/read/28827975/architecture-and-transport-properties-of-multifilamentary-mgb2-strands-for-mri-and-low-ac-loss-applications
#11
F Wan, M D Sumption, M A Rindfleisch, M J Tomsic, E W Collings
Standard in-situ type MgB2 strands manufactured by Hyper Tech Inc have 19 - 36 subelements, a monel outer sheath, and a Cu interfilamentary matrix. Typical transport Jc s of the strands are 2×10(5) A/cm(2) with n-values of 20 - 30 at 4.2 K and 5 T. This work introduces two new MgB2 conductor designs. First, a new class of MgB2 strand is designed for magnetic resonance imaging applications. This type has a higher Cu content designed to enhance protection of a magnet wound with it, and a larger diameter to increase the critical current...
June 2017: IEEE Transactions on Applied Superconductivity: a Publication of the IEEE Superconductivity Committee
https://www.readbyqxmd.com/read/28827827/transient-expression-of-zbtb32-in-anti-viral-cd8-t-cells-limits-the-magnitude-of-the-effector-response-and-the-generation-of-memory
#12
Hyun Mu Shin, Varun N Kapoor, Gwanghun Kim, Peng Li, Hang-Rae Kim, M Suresh, Susan M Kaech, E John Wherry, Liisa K Selin, Warren J Leonard, Raymond M Welsh, Leslie J Berg
Virus infections induce CD8+ T cell responses comprised of a large population of terminal effector cells and a smaller subset of long-lived memory cells. The transcription factors regulating the relative expansion versus the long-term survival potential of anti-viral CD8+ T cells are not completely understood. We identified ZBTB32 as a transcription factor that is transiently expressed in effector CD8+ T cells. After acute virus infection, CD8+ T cells deficient in ZBTB32 showed enhanced virus-specific CD8+ T cell responses, and generated increased numbers of virus-specific memory cells; in contrast, persistent expression of ZBTB32 suppressed memory cell formation...
August 21, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28827754/t-follicular-helper-cells-and-antibody-response-to-hepatitis-b-virus-vaccine-in-hiv-1-infected-children-receiving-art
#13
Yonas Bekele, Desalegn Yibeltal, Kidist Bobosha, Temesgen E Andargie, Mahlet Lemma, Meseret Gebre, Eyasu Mekonnen, Abiy Habtewold, Anna Nilsson, Abraham Aseffa, Rawleigh Howe, Francesca Chiodi
HBV vaccine has 95% efficacy in children to prevent HBV infection and related cancer. We conducted a prospective study in HIV-1 infected children receiving ART (n = 49) and controls (n = 63) to assess humoral and cellular responses to HBV vaccine provided with three doses under an accelerated schedule of 4 weeks apart. At 1 month post-vaccination all children, except 4 HIV-1 infected, displayed protective antibody (ab) titers to HBV vaccine; ab titers were lower in infected children (P < 0.0001)...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28826982/changes-in-the-availability-of-bedside-ultrasound-practice-in-emergency-rooms-and-pre-hospital-settings-in-france
#14
X Bobbia, M Abou-Badra, N Hansel, P Pes, T Petrovic, P G Claret, J Y Lefrant, J E de la Coussaye
OBJECTIVE: Ensuring the availability of ultrasound devices is the initial step in implementing clinical ultrasound (CUS) in emergency services. In France in 2011, 52% of emergency departments (EDs) and only 9% of mobile intensive care stations (MICS) were equipped with ultrasound devices. The main goal of this study was to determine the movement of these rates since 2011. METHODS: We conducted a cross-sectional, descriptive, multi-centre study in the form of a questionnaire...
August 4, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28826845/association-between-dietary-energy-density-and-obesity-associated-cancer-results-from-the-women-s-health-initiative
#15
Cynthia A Thomson, Tracy E Crane, David O Garcia, Betsy C Wertheim, Melanie Hingle, Linda Snetselaar, Mridul Datta, Thomas Rohan, Erin LeBlanc, Rowan T Chlebowski, Lihong Qi
BACKGROUND: Dietary energy density (DED) is the ratio of energy (kilocalories or kilojoules) intake to food weight (grams) and is a measure of diet quality. Consumption of foods high in DED has been associated with weight gain in adults. OBJECTIVE: To investigate the association between baseline DED and incident obesity-associated cancers in the Women's Health Initiative. DESIGN: Prospective cohort study of clinical trial and observational study participants...
August 8, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28826616/updated-analysis-of-calgb-alliance-100104-assessing-lenalidomide-versus-placebo-maintenance-after-single-autologous-stem-cell-transplantation-for-multiple-myeloma-a-randomised-double-blind-phase-3-trial
#16
Sarah A Holstein, Sin-Ho Jung, Paul G Richardson, Craig C Hofmeister, David D Hurd, Hani Hassoun, Sergio Giralt, Edward A Stadtmauer, Daniel J Weisdorf, Ravi Vij, Jan S Moreb, Natalie S Callander, Koen van Besien, Teresa G Gentile, Luis Isola, Richard T Maziarz, Asad Bashey, Heather Landau, Thomas Martin, Muzaffar H Qazilbash, Cesar Rodriguez, Brian McClune, Robert L Schlossman, Scott E Smith, Vera Hars, Kouros Owzar, Chen Jiang, Molly Boyd, Chelsea Schultz, Marcia Wilson, Parameswaran Hari, Marcelo C Pasquini, Mary M Horowitz, Thomas C Shea, Steven M Devine, Charles Linker, Kenneth C Anderson, Philip L McCarthy
BACKGROUND: In the CALGB (Alliance) 100104 study, lenalidomide versus placebo after autologous stem-cell transplantation (ASCT) was investigated for patients with newly diagnosed myeloma. That study showed improved time to progression and overall survival and an increase in second primary malignancies for lenalidomide at a median follow-up of 34 months. Here we report an updated intention-to-treat analysis of CALGB (Alliance) 100104 at a median follow-up of 91 months. METHODS: Patients were eligible for this randomised, double-blind, placebo-controlled, phase 3 trial if they had symptomatic disease requiring treatment; had received, at most, two induction regimens; and had achieved stable disease or better in the first 100 days after ASCT...
August 17, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28826410/altered-functional-connectivity-of-the-subthalamus-and-the-bed-nucleus-of-the-stria-terminalis-in-obsessive-compulsive-disorder
#17
M Cano, P Alonso, I Martínez-Zalacaín, M Subirà, E Real, C Segalàs, J Pujol, N Cardoner, J M Menchón, C Soriano-Mas
BACKGROUND: The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of other clinically-effective DBS targets have not been explored. Here we evaluated the FC patterns of the subthalamic nucleus (STN) and the bed nucleus of the stria terminalis (BNST) in patients with OCD, as well as their association with symptom severity...
August 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28823033/the-combination-of-mitomycin-induced-blood-cells-with-a-temporary-treatment-of-ciclosporin-a-prolongs-allograft-survival-in-vascularized-composite-allotransplantation
#18
Christian Andreas Radu, Sebastian Fischer, Yannick Diehm, Otto Hetzel, Florian Neubrech, Laura Dittmar, Christian Kleist, Martha Maria Gebhard, Peter Terness, Ulrich Kneser, Jurij Kiefer
BACKGROUND: Vascularized composite allotransplantation (VCA) is a rapidly expanding field of transplantation and provides a potential treatment for complex tissue defects. Peripheral blood mononuclear cells (PBMCs) shortly incubated with the antibiotic and chemotherapeutic agent mitomycin C (MMC) can suppress allogeneic T cell response and control allograft rejection in various organ transplantation models. MMC-incubated PBMCs (MICs) are currently being tested in a phase I clinical trial in kidney transplant patients...
August 19, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28822909/variation-in-basal-body-localisation-and-targeting-of-trypanosome-rp2-and-for20-proteins
#19
Jane Harmer, Xin Qi, Gabriella Toniolo, Aysha Patel, Hannah Shaw, Fiona E Benson, Michael L Ginger, Paul G McKean
TOF-LisH-PLL motifs define FOP family proteins; some members are involved in flagellum assembly. The critical role of FOP family protein FOR20 is poorly understood. Here, we report relative localisations of the four FOP family proteins in parasitic Trypanosoma brucei: TbRP2, TbOFD1 and TbFOP/FOP1-like are mature basal body proteins whereas TbFOR20 is present on pro- and mature basal bodies - on the latter it localises distal to TbRP2. We discuss how the data, together with published work for another protist Giardia intestinalis, informs on likely FOR20 function...
July 13, 2017: Protist
https://www.readbyqxmd.com/read/28822870/maternal-obesity-and-attention-related-symptoms-in-the-preterm-offspring
#20
Jelske W van der Burg, Elizabeth T Jensen, Margot van de Bor, Robert M Joseph, T Michael O'Shea, Karl Kuban, Elizabeth N Allred, Megan Scott, Scott Hunter, Stephen R Hooper, Olaf Dammann, Alan Leviton
BACKGROUND: Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm. AIM: To estimate the risk of attention problems at age 10years in children born very preterm to overweight (i.e., body mass index (BMI) 25-29kg/m(2)) and obese (i.e., BMI≥30kg/m(2)) women relative to the risk among children born to women who were neither overweight nor obese (i...
August 17, 2017: Early Human Development
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