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https://www.readbyqxmd.com/read/28728164/disseminated-tumour-cells-with-highly-aberrant-genomes-are-linked-to-poor-prognosis-in-operable-oesophageal-adenocarcinoma
#1
Sarah Schumacher, Christoph Bartenhagen, Martin Hoffmann, Daniel Will, Johannes C Fischer, Stephan E Baldus, Christian Vay, Georg Fluegen, Levent Dizdar, Daniel Vallböhmer, Christoph A Klein, Wolfram T Knoefel, Nikolas H Stoecklein, Birte Möhlendick
BACKGROUND: Chromosomal instability (CIN) has repeatedly been identified as a prognostic marker. Here we evaluated the percentage of aberrant genome per cell (PAG) as a measure of CIN in single disseminated tumour cells (DTC) isolated from patients with operable oesophageal adenocarcinoma (EAC), to assess the impact of CIN(high) DTCs on prognosis. METHODS: We isolated CK18(positive) DTCs from bone marrow (BM) or lymph node (LN) preparations of operable EAC patients...
July 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28728133/zebrafish-have-an-ethanol-inducible-hepatic-4-nitrophenol-hydroxylase-that-is-not-cyp2e1-like
#2
Jessica H Hartman, Jordan S Kozal, Richard T Di Giulio, Joel N Meyer
Zebrafish are an attractive model organism for toxicology; however, an important consideration in translating between species is xenobiotic metabolism/bioactivation. CYP2E1 metabolizes small hydrophobic molecules, e.g. ethanol, cigarette smoke, and diesel exhaust components. CYP2E1 is thought to only be conserved in mammals, but recent reports identified homologous zebrafish cytochrome P450s. Herein, ex vivo biochemical measurements show that unlike mammals, zebrafish possess a low-affinity 4-nitrophenol hydroxylase (Km ∼0...
July 10, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28728127/is-bacterial-luminescence-response-to-low-dose-radiation-associated-with-mutagenicity
#3
T V Rozhko, O A Guseynov, V E Guseynova, A A Bondar, A N Devyatlovskaya, N S Kudryasheva
Luminous marine bacteria are widely used in bioassays with luminescence intensity being a physiological parameter tested. The purpose of the study was to determine whether bacterial genetic alteration is responsible for bioluminescence kinetics change under low-dose radiation exposure. The alpha-emitting radionuclide (241)Am and beta-emitting radionuclide (3)H were used as the sources of low-dose ionizing radiation. Changes of bioluminescence kinetics of Photobacterium phosphoreum in solutions of (241)Am(NO3)3, 7 kBq/L, and tritiated water, 100 MBq/L, were studied; bioluminescence kinetics stages (absence of effect, activation, and inhibition) were determined...
July 17, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28728093/obsessive-compulsive-disorder-in-the-elderly-a-report-from-the-international-college-of-obsessive-compulsive-disorders-icocs
#4
B Dell'Osso, B Benatti, C I Rodriguez, C Arici, C Palazzo, A C Altamura, E Hollander, N Fineberg, D J Stein, H Nicolini, N Lanzagorta, D Marazziti, S Pallanti, M Van Ameringen, C Lochner, O Karamustafalioglu, L Hranov, M Figee, L Drummond, J Grant, D Denys, D Cath, J M Menchon, J Zohar
INTRODUCTION: Obsessive-compulsive disorder (OCD) is a highly disabling condition, with frequent early onset. Adult/adolescent OCD has been extensively investigated, but little is known about prevalence and clinical characterization of geriatric patients with OCD (G-OCD≥65years). The present study aimed to assess prevalence of G-OCD and associated socio-demographic and clinical correlates in a large international sample. METHODS: Data from 416 outpatients, participating in the ICOCS network, were assessed and categorized into 2 groups, age<vs≥65years, and then divided on the basis of the median age of the sample (age<vs≥42years)...
July 4, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28727994/retrospective-evaluation-of-the-procedural-sedation-practices-of-expert-nurses-during-abortion-care
#5
Monica R McLemore, E Angel Aztlan
OBJECTIVE: To evaluate the provision of procedural sedation during abortion by expert nurses and to describe the factors that are associated with time to discharge for women who receive this sedation. DESIGN: Retrospective chart review. METHODS: Descriptive statistics were generated to describe a retrospective cohort of women presenting for abortion under procedural sedation. Analysis of variance was used to determine significant characteristics that influenced time to discharge...
July 17, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28727837/differing-roles-for-short-chain-fatty-acids-and-gpr43-agonism-in-the-regulation-of-intestinal-barrier-function-and-immune-responses
#6
Warren N D'Souza, Jason Douangpanya, Sharon Mu, Peter Jaeckel, Ming Zhang, Joseph R Maxwell, James B Rottman, Katja Labitzke, Angela Willee, Holger Beckmann, Yingcai Wang, Yang Li, Ralf Schwandner, James A Johnston, Jennifer E Towne, Hailing Hsu
Inflammatory bowel disease (IBD) is associated with a loss of intestinal barrier function and dysregulated immune responses. It has been shown that short chain fatty acids (SCFAs) are protective in IBD and that GPR43 mediates the protective effects of SCFAs. In this study, we investigated the effects of SCFAs in comparison to highly specific GPR43 agonists on human intestinal epithelial and immune cells. Our results confirm that SCFAs are enhancers of barrier function in intestinal epithelial cells. Additionally, SCFAs also displayed potent immunoregulatory properties based upon the ability to inhibit LPS-induced cytokine production in PBMC, and human T cell proliferation and cytokine production...
2017: PloS One
https://www.readbyqxmd.com/read/28727827/diversity-and-phylogenetic-relationships-among-bartonella-strains-from-thai-bats
#7
Clifton D McKee, Michael Y Kosoy, Ying Bai, Lynn M Osikowicz, Richard Franka, Amy T Gilbert, Sumalee Boonmar, Charles E Rupprecht, Leonard F Peruski
Bartonellae are phylogenetically diverse, intracellular bacteria commonly found in mammals. Previous studies have demonstrated that bats have a high prevalence and diversity of Bartonella infections globally. Isolates (n = 42) were obtained from five bat species in four provinces of Thailand and analyzed using sequences of the citrate synthase gene (gltA). Sequences clustered into seven distinct genogroups; four of these genogroups displayed similarity with Bartonella spp. sequences from other bats in Southeast Asia, Africa, and Eastern Europe...
2017: PloS One
https://www.readbyqxmd.com/read/28727322/hfe-gene-polymorphism-defined-by-sequence-based-typing-of-the-brazilian-population-and-a-standardized-nomenclature-for-hfe-allele-sequences
#8
W N Campos, J D Massaro, A L C Martinelli, J A Halliwell, S G E Marsh, C T Mendes-Junior, E A Donadi
The HFE molecule controls iron uptake from gut, and defects in the molecule have been associated with iron overload, particularly in hereditary hemochromatosis. The HFE gene including both coding and boundary intronic regions were sequenced in 304 Brazilian individuals, encompassing healthy individuals and patients exhibiting hereditary or acquired iron overload. Six sites of variation were detected: i) H63D C > G in exon 2, ii) IVS2 (+4) T > C in intron 2, iii) a C > G transversion in intron 3, iv) C282Y G > A in exon 4, v) IVS4 (-44) T > C in intron 4, and vi) a new Guanine deletion (G > del) in intron 5, which were used for haplotype inference...
July 20, 2017: HLA
https://www.readbyqxmd.com/read/28727147/the-role-of-medical-nursing-skills-training-in-caregiver-confidence-and-burden-a-cancors-study
#9
Michelle A Mollica, Kristin Litzelman, Julia H Rowland, Erin E Kent
BACKGROUND: Informal cancer caregivers provide essential support to cancer patients, including performing direct medical/nursing tasks, assisting with activities of daily living, and offering social support. This study examined associations between the receipt of medical/nursing skills training and the caregiver burden as well as the mediation of caregiving confidence on this relationship in a sample of caregivers of lung and colorectal cancer patients. METHODS: Caregivers who had been identified by cancer patients in the Cancer Care Outcomes Research and Surveillance consortium completed a questionnaire assessing the care provided, the type of medical/nursing skills training received, the burden (measured with the modified short-form Zarit Burden Interview), and the confidence in caring for their patient's physical needs...
July 20, 2017: Cancer
https://www.readbyqxmd.com/read/28727109/national-beef-quality-audit-2016-in-plant-survey-of-carcass-characteristics-related-to-quality-quantity-and-value-of-fed-steers-and-heifers
#10
C A Boykin, L C Eastwood, M K Harris, D S Hale, C R Kerth, D B Griffin, A N Arnold, J D Hasty, K E Belk, D R Woerner, R J Delmore, J N Martin, D L VanOverbeke, G G Mafi, M M Pfeiffer, T E Lawrence, T J McEvers, T B Schmidt, R J Maddock, D D Johnson, C C Carr, J M Scheffler, T D Pringle, A M Stelzleni, J Gottlieb, J W Savell
The National Beef Quality Audit (NBQA)-2016 used in-plant cooler assessments to benchmark the current status of the fed steer and heifer beef industry in the United States. In-plant cooler assessments ( = 9,106 carcasses) were conducted at 30 facilities, where approximately 10% of a single day's production were evaluated for USDA quality grade (QG) and yield grade (YG) factors. Frequencies of evaluated traits were 66.5% steer and 33.4% heifer sex classes and 82.9% native, 15.9% dairy-type, and 1.2% estimated breed types...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727107/national-beef-quality-audit-2016-survey-of-carcass-characteristics-through-instrument-grading-assessments
#11
C A Boykin, L C Eastwood, M K Harris, D S Hale, C R Kerth, D B Griffin, A N Arnold, J D Hasty, K E Belk, D R Woerner, R J Delmore, J N Martin, D L VanOverbeke, G G Mafi, M M Pfeiffer, T E Lawrence, T J McEvers, T B Schmidt, R J Maddock, D D Johnson, C C Carr, J M Scheffler, T D Pringle, A M Stelzleni, J Gottlieb, J W Savell
The instrument grading assessment portion of the National Beef Quality Audit (NBQA) - 2016 allows the unique opportunity to evaluate beef carcass traits over the course of a year. One week of instrument grading data was collected each month from 5 beef processing corporations encompassing 18 facilities from January 2016 through December 2016 ( = 4,544,635 carcasses). Mean USDA yield grade (YG) was 3.1 with 1.37 cm fat thickness (FT), 88.9 cm LM area, 393.6 kg HCW, and 2.1% KPH. Frequency distribution of USDA YG was 9...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727089/the-use-of-oxidative-stress-biomarkers-in-live-animals-in-vivo-to-predict-meat-quality-deterioration-postmortem-in-vitro-caused-by-changes-in-muscle-biochemical-components
#12
E N Ponnampalam, D L Hopkins, K Giri, J L Jacobs, T Plozza, P Lewandowski, A Bekhit
This study was conducted to determine whether circulating concentrations of blood isoprostanes can be used as an effective biomarker in lambs to predict degradation of color and/or lipid stability in meat. Lambs ( = 84) were fed diets of either lucerne pasture, annual ryegrass pasture, a commercial feedlot pellet, or a combination of annual ryegrass and feedlot pellet for 8 wk, including a 2-wk adaptation period. Blood isoprostane concentration at wk 0, 4, 6 or 8 of feeding was determined. Blood isoprostane concentration for each animal was then correlated with muscle biochemical components that impact color and/or lipid oxidative status during retail display...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727087/effects-of-zilpaterol-hydrochloride-on-methane-production-total-body-oxygen-consumption-and-blood-metabolites-in-finishing-beef-steers
#13
K E Hales, A P Foote, D W Brake, T M Brown-Brandl, V M Artegoitia, H C Freetly
An indirect calorimetry experiment was conducted to determine the effects of feeding zilpaterol hydrochloride (ZH) for 20 d on total body oxygen consumption, respiratory quotient, methane production, and blood metabolites in finishing beef steers. Sixteen Angus steers (initial BW = 555 ± 12.7 kg) were individually fed at ad libitum intake and used in a completely randomized design. The model included the fixed effects of dietary treatment, day, and treatment × day. Dry matter intake did not differ between the treatments ( = 0...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727060/effect-of-monensin-inclusion-on-intake-digestion-and-ruminal-fermentation-parameters-by-bos-taurus-indicus-and-bos-taurus-taurus-steers-consuming-bermudagrass-hay
#14
N L Bell, R C Anderson, T R Callaway, M O Franco, J E Sawyer, T A Wickersham
Effects of monensin inclusion and cattle subspecies on utilization of bermudagrass hay (13.7% CP, 77.3% NDF, and 38.8% ADF) were evaluated using ruminally cannulated steers (5 [BI] and 5 [BT]; 398 kg BW). Subspecies were concurrently subjected to a 2-period, 2-treatment crossover design. Treatments were 0 (CON) or 200 mg·steer·d monensin (MON) in 0.91 kg dried distillers' grains with solubles. Periods were 70 d in length: 20 d of adaptation, 22 d of sample collection, and 28 d for withdrawal of treatment...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727052/rapid-communication-subclinical-bovine-respiratory-disease-loci-and-pathogens-associated-with-lung-lesions-in-feedlot-cattle
#15
J N Kiser, T E Lawrence, M Neupane, C M Seabury, J F Taylor, J E Womack, H L Neibergs
Bovine respiratory disease (BRD) is an economically important disease of feedlot cattle that is caused by viral and bacterial pathogen members of the BRD complex. Many cases of subclinical BRD go untreated and are not detected until slaughter, when lung lesions are identified. The objectives of this study were to identify which BRD pathogens were associated with the presence of lung lesions at harvest and to identify genomic loci that were associated with susceptibility to lung lesions as defined by consolidation of the lung and/or the presence of fibrin tissue...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727043/effect-of-monensin-withdrawal-on-intake-digestion-and-ruminal-fermentation-parameters-by-bos-taurus-indicus-and-bos-taurus-taurus-steers-consuming-bermudagrass-hay
#16
N L Bell, T R Callaway, R C Anderson, M O Franco, J E Sawyer, T A Wickersham
Effects of monensin withdrawal and cattle subspecies on the utilization of bermudagrass hay (14.3% CP, 72.3% NDF, and 36.9% ADF) were evaluated using ruminally cannulated steers (5 [BI] and 5 [BT]). Subspecies were concurrently subjected to a 2-period, 2-treatment crossover design. Treatments consisted of either 0 mg·steer·d-1 monensin with no previous monensin feeding (CON) or withdrawal from 200 mg·steer·d-1 monensin (MON) fed individually in 0.91 kg dried distillers' grains with solubles for 42 d. Withdrawal was evaluated for a 28-d period...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727030/apparent-and-true-ileal-and-total-tract-digestibility-of-fat-in-canola-press-cake-or-canola-oil-and-effects-of-increasing-dietary-fat-on-amino-acid-and-energy-digestibility-in-growing-pigs
#17
X Zhou, E Beltranena, R T Zijlstra
Digestibility of remaining oil in canola press-cake (CPC) may be lower than that of extracted, liquid canola oil (CO) because oil may be partly entrapped in the CPC matrix. To determine true digestibility of fat in ingredients, endogenous fat losses should be estimated. Dietary fat may interact with digestion of other dietary components. To test these hypotheses, 10 ileal-cannulated pigs (initial BW, 25.4 kg) were fed 10 diets for 8 periods in a 10 × 8 Youden square. A basal diet was formulated based on wheat, barley, and canola meal...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727026/impact-of-alternative-definitions-of-contemporary-groups-on-genetic-evaluations-of-traits-recorded-at-lambing
#18
N McHugh, T Pabiou, E Wall, K McDermott, D P Berry
The objective of this study was to quantify the impact of alternative contemporary group definitions for lambing traits on genetic evaluations in the Irish multibreed sheep population. Three lambing traits were considered for analysis: lambing difficulty, birth weight, and survival. Eight alternative contemporary group definitions were investigated for each lambing trait; all contemporary groups were formed within flock of lambing and included (flock by) week of lambing, week of lambing by litter size (i.e...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726646/the-prognostic-significance-of-combaind-expression-of-zap-70-and-cd38-in-chronic-lymphocytic-leukemia
#19
T Kirtava, T Vatsadze, E Azrmaiparashili, D Ghirdaladze
Our aim was to assess the inter links of the markers CD38 and ZAP-70 based on our materials, the attitude according to the disease stage, and to document which of them had leading meaning for prognosis and treatmend of the disease. In our study we have used flow cytometry for detection CD38 and ZAP-70+ markers expression. (58 patients to assessments their prognostic value in сhronic lymphocytic leukemia (CLL), Correlation to Rai stages and relationships between this markers and outcome of therapy). We divided all patients in two groups based on level of ZAP-70+ cell and CD38+cells,(I group-patients) ZAP-70+ cells <20% CD38+<30% and ZAP-70+ cells >20% and CD38>30%,(II group) becaus our in investigation shows, that ZAP -70+ is very importance independent prognoctic marker as why in ZAP-70+ cases when its number was <20%, patients had favorable prognosis - the big part of them (13(40...
June 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28726580/high-intensity-and-simultaneous-alcohol-and-marijuana-use-among-high-school-seniors-in-the-u-s
#20
Megan E Patrick, Philip T Veliz, Yvonne M Terry-McElrath
BACKGROUND: Simultaneous alcohol and marijuana (SAM) use poses threats to health, particularly among adolescents. These risks would be exacerbated to the extent that high-intensity drinking (e.g., 10+ drinks in a row) and marijuana use (e.g., 1+ joints per day) are associated with a higher likelihood of SAM use. The current study examines the extent to which the intensity of alcohol use and of marijuana use are associated with adolescent SAM use prevalence, and whether associations remain after controlling for key covariates known to associate with both alcohol and marijuana use; it identifies alcohol and marijuana use intensity levels associated with the highest risk of adolescent SAM use...
July 20, 2017: Substance Abuse
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