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https://www.readbyqxmd.com/read/29050399/diagnostic-criteria-for-chronic-lymphocytic-inflammation-with-pontine-perivascular-enhancement-responsive-to-steroids-clippers
#1
W Oliver Tobin, Yong Guo, Karl N Krecke, Joseph E Parisi, Claudia F Lucchinetti, Sean J Pittock, Jay Mandrekar, Divyanshu Dubey, Jan Debruyne, B Mark Keegan
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a central nervous system inflammatory syndrome predominantly affecting the brainstem, cerebellum, and spinal cord. Following its initial description, the salient features of CLIPPERS have been confirmed and expanded upon, but the lack of formalized diagnostic criteria has led to reports of patients with dissimilar features purported to have CLIPPERS. We evaluated clinical, radiological and pathological features of patients referred for suspected CLIPPERS and propose diagnostic criteria to discriminate CLIPPERS from non-CLIPPERS aetiologies...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050383/early-detection-of-consciousness-in-patients-with-acute-severe-traumatic-brain-injury
#2
Brian L Edlow, Camille Chatelle, Camille A Spencer, Catherine J Chu, Yelena G Bodien, Kathryn L O'Connor, Ronald E Hirschberg, Leigh R Hochberg, Joseph T Giacino, Eric S Rosenthal, Ona Wu
See Schiff (doi:10.1093/awx209) for a scientific commentary on this article. Patients with acute severe traumatic brain injury may recover consciousness before self-expression. Without behavioural evidence of consciousness at the bedside, clinicians may render an inaccurate prognosis, increasing the likelihood of withholding life-sustaining therapies or denying rehabilitative services. Task-based functional magnetic resonance imaging and electroencephalography techniques have revealed covert consciousness in the chronic setting, but these techniques have not been tested in the intensive care unit...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050367/expression-and-clinical-association-of-programmed-cell-death-1-programmed-death-ligand-1-and-cd8-lymphocytes-in-primary-sarcomas-is-subtype-dependent
#3
Anke E M van Erp, Yvonne M H Versleijen-Jonkers, Melissa H S Hillebrandt-Roeffen, Laurens van Houdt, Mark A J Gorris, Laura S van Dam, Thomas Mentzel, Marije E Weidema, C Dilara Savci-Heijink, Ingrid M E Desar, Hans H M Merks, Max M van Noesel, Janet Shipley, Winette T A van der Graaf, Uta E Flucke, Friederike A G Meyer-Wentrup
In order to explore the potential of immune checkpoint blockade in sarcoma, we investigated expression and clinical relevance of programmed cell death-1 (PD-1), programmed death ligand-1 (PD-L1) and CD8 in tumors of 208 sarcoma patients. Primary untreated osteosarcoma (n = 46), Ewing sarcoma (n = 32), alveolar rhabdomyosarcoma (n = 20), embryonal rhabdomyosarcoma (n = 77), synovial sarcoma (n = 22) and desmoplastic small round cell tumors (DSRCT) (n = 11) were examined immunohistochemically. PD-L1 expression was predominantly detected in alveolar and embryonal rhabdomyosarcomas (15% and 16%, respectively)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049525/impact-of-the-haga-braincare-strategy-on-the-burden-of-haemodynamic-and-embolic-strokes-related-to-cardiac-surgery
#4
Friso Duynstee, Ruud W M Keunen, Agnes van Sonderen, Ali M Keyhan-Falsafi, Gerard J F Hoohenkerk, Gayleen Stephens, Erik Teeuws, Jan W K van Alphen, Dénes L J Tavy, Arne Mosch, Sebastiaan F T M de Bruijn, Hans van Overhagen, Frank E E Treurniet, Lucas C van Dijk, Paulien M van Kampen
OBJECTIVES: This study prospectively evaluates the impact of the Haga Braincare Strategy (HBS) on the occurrence of haemodynamic and embolic stroke in a cohort of patients who underwent coronay artery bypass grafting (CABG), valve replacement of a combination of both types of surgery between 2012 and 2015 at the Haga Teaching Hospitals. METHODS: The HBS is a dual strategy based on a preoperative vascular work-up of the cerebral circulation by transcranial Doppler and a perioperative monitoring of the cerebral circulation by cerebral oximetry...
June 15, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049457/association-of-patient-frailty-with-increased-morbidity-after-common-ambulatory-general-surgery-operations
#5
Carolyn D Seib, Holly Rochefort, Kathryn Chomsky-Higgins, Jessica E Gosnell, Insoo Suh, Wen T Shen, Quan-Yang Duh, Emily Finlayson
Importance: Frailty is a measure of decreased physiological reserve that is associated with morbidity and mortality in major elective and emergency general surgery operations, independent of chronological age. To date, the association of frailty with outcomes in ambulatory general surgery has not been established. Objective: To determine the association between frailty and perioperative morbidity in patients undergoing ambulatory general surgery operations. Design, Setting, and Participants: A retrospective cohort study was conducted of 140 828 patients older than 40 years of age from the 2007-2010 American College of Surgeons National Surgical Quality Improvement Program Participant Use File who underwent ambulatory and 23-hour-stay hernia, breast, thyroid, or parathyroid surgery...
October 11, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29049345/processing-of-the-major-autolysin-of-e-faecalis-atla-by-the-zinc-metalloprotease-gele-impacts-atla-septal-localization-and-cell-separation
#6
Emily K Stinemetz, Peng Gao, Kenneth L Pinkston, Maria Camila Montealegre, Barbara E Murray, Barrett R Harvey
AtlA is the major peptidoglycan hydrolase of Enterococcus faecalis involved in cell division and cellular autolysis. The secreted zinc metalloprotease, gelatinase (GelE), has been identified as an important regulator of cellular function through post-translational modification of protein substrates. AtlA is a known target of GelE, and their interplay has been proposed to regulate AtlA function. To study the protease-mediated post-translational modification of AtlA, monoclonal antibodies were developed as research tools...
2017: PloS One
https://www.readbyqxmd.com/read/29049267/variation-among-pediatric-orthopaedic-surgeons-when-treating-medial-epicondyle-fractures
#7
Meghan Hughes, Karan Dua, Nathan N O'Hara, Brian K Brighton, Theodore J Ganley, William L Hennrikus, Martin J Herman, Joshua E Hyman, J Todd Lawrence, Charles T Mehlman, Kenneth J Noonan, Norman Y Otsuka, Richard M Schwend, M Wade Shrader, Brian G Smith, Paul D Sponseller, Joshua M Abzug
BACKGROUND: Medial epicondyle fractures are a common pediatric and adolescent injury accounting for 11% to 20% of elbow fractures in this population. This purpose of this study was to determine the variability among pediatric orthopaedic surgeons when treating pediatric medial epicondyle fractures. METHODS: A discrete choice experiment was conducted to determine which patient and injury attributes influence the management of medial epicondyle fractures by pediatric orthopaedic surgeons...
October 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29048753/medication-errors-at-hospital-admission-and-discharge-in-type-1-and-2-diabetes
#8
C Breuker, V Macioce, T Mura, Y Audurier, C Boegner, A Jalabert, M Villiet, A Castet-Nicolas, A Avignon, A Sultan
AIMS: To assess the prevalence and characteristics of medication errors at hospital admission and discharge in people with Type 1 and Type 2 diabetes, and identify potential risk factors for these errors. METHODS: This prospective observational study included all people with Type 1 (n = 163) and Type 2 diabetes (n = 508) admitted to the Diabetology-Department of the University Hospital of Montpellier, France, between 2013 and 2015. Pharmacists conducted medication reconciliation within 24 h of admission and at hospital discharge...
October 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29048751/severity-strata-for-five-patient-reported-outcomes-in-adults-with-atopic-dermatitis
#9
P P Vakharia, R Chopra, R Sacotte, N Patel, S Immaneni, T White, R Kantor, D Y Hsu, E L Simpson, J I Silverberg
BACKGROUND: Multiple patient-reported outcomes have been used to assess the burden of atopic dermatitis (AD). Some are disease specific, e.g. the Patient Oriented Eczema Measure (POEM). While others pertain to itch, e.g. Numerical Rating Scale (NRS)-itch, ItchyQoL and 5-D itch, or dermatologic disease in general, e.g. Dermatology Life Quality Index (DLQI). Development of severity strata is essential for proper interpretability of these assessments. We sought to confirm previously developed strata for POEM, DLQI and raw ItchyQoL, and develop strata for the NRS-itch, mean ItchyQOL and 5-D itch scale for use in adults with AD...
October 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29048482/n-acetylglucosamine-more-than-a-silent-partner-in-insulin-resistance
#10
Geoffrey G Hesketh, James W Dennis
Pedersen et al. (Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, et al. 2016. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature. 535: 376-381.) report that human serum levels of branched-chain amino acids (BCAA) and N-acetylglucosamine (GlcNAc) increase in proportion to insulin resistance. They focus on the microbiome and the contributing subset of microbe species, thereby demonstrating disease causality in mice...
July 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/29048177/the-role-of-a-palliative-care-intervention-in-moderating-the-relationship-between-depression-and-survival-among-individuals-with-advanced-cancer
#11
Anna T Prescott, Jay G Hull, J Nicholas Dionne-Odom, Tor D Tosteson, Kathleen Doyle Lyons, Zhigang Li, Zhongze Li, Konstantin H Dragnev, Mark T Hegel, Karen E Steinhauser, Tim A Ahles, Marie A Bakitas
OBJECTIVE: Randomized controlled trials (RCTs) of early palliative care interventions in advanced cancer have positively impacted patient survival, yet the mechanisms remain unknown. This secondary analysis of 2 RCTs assessed whether an early palliative care intervention moderates the relationship between depressive symptoms and survival. METHOD: The relationships among mood, survival, and early palliative care intervention were studied among 529 advanced cancer patients who participated in 2 RCTs...
October 19, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29048046/absolute-calibration-of-optical-streak-cameras-on-picosecond-time-scales-using-supercontinuum-generation
#12
S Patankar, E T Gumbrell, T S Robinson, E Floyd, N H Stuart, A S Moore, J W Skidmore, R A Smith
We report a new method using high-stability, laser-driven supercontinuum generation in a liquid cell to calibrate the absolute photon response of fast optical streak cameras as a function of wavelength when operating at fastest sweep speeds. A stable, pulsed white light source based around the use of self-phase modulation in a salt solution was developed to provide the required brightness on picosecond time scales, enabling streak camera calibration in fully dynamic operation. The measured spectral brightness allowed for absolute photon response calibration over a broad spectral range (425-650 nm)...
August 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047943/feasibility-study-of-a-space-based-high-pulse-energy-2%C3%A2-%C3%A2-%C3%AE-m-co2-ipda-lidar
#13
Upendra N Singh, Tamer F Refaat, Syed Ismail, Kenneth J Davis, Stephan R Kawa, Robert T Menzies, Mulugeta Petros
Sustained high-quality column carbon dioxide (CO2) atmospheric measurements from space are required to improve estimates of regional and continental-scale sources and sinks of CO2. Modeling of a space-based 2 μm, high pulse energy, triple-pulse, direct detection integrated path differential absorption (IPDA) lidar was conducted to demonstrate CO2 measurement capability and to evaluate random and systematic errors. Parameters based on recent technology developments in the 2 μm laser and state-of-the-art HgCdTe (MCT) electron-initiated avalanche photodiode (e-APD) detection system were incorporated in this model...
August 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047908/composite-infrared-spectrometer-cirs-on-cassini-publisher-s-note
#14
D E Jennings, F M Flasar, V G Kunde, C A Nixon, M E Segura, P N Romani, N Gorius, S Albright, J C Brasunas, R C Carlson, A A Mamoutkine, E Guandique, M S Kaelberer, S Aslam, R K Achterberg, G L Bjoraker, C M Anderson, V Cottini, J C Pearl, M D Smith, B E Hesman, R D Barney, S Calcutt, T J Vellacott, L J Spilker, S G Edgington, S M Brooks, P Ade, P J Schinder, A Coustenis, R Courtin, G Michel, R Fettig, S Pilorz, C Ferrari
This publisher's note renumbers the reference list in Appl. Opt.56, 5274 (2017)APOPAI0003-693510.1364/AO.56.005274.
July 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047582/composite-infrared-spectrometer-cirs-on-cassini
#15
D E Jennings, F M Flasar, V G Kunde, C A Nixon, M E Segura, P N Romani, N Gorius, S Albright, J C Brasunas, R C Carlson, A A Mamoutkine, E Guandique, M S Kaelberer, S Aslam, R K Achterberg, G L Bjoraker, C M Anderson, V Cottini, J C Pearl, M D Smith, B E Hesman, R D Barney, S Calcutt, T J Vellacott, L J Spilker, S G Edgington, S M Brooks, P Ade, P J Schinder, A Coustenis, R Courtin, G Michel, R Fettig, S Pilorz, C Ferrari
The Cassini spacecraft orbiting Saturn carries the composite infrared spectrometer (CIRS) designed to study thermal emission from Saturn and its rings and moons. CIRS, a Fourier transform spectrometer, is an indispensable part of the payload providing unique measurements and important synergies with the other instruments. It takes full advantage of Cassini's 13-year-long mission and surpasses the capabilities of previous spectrometers on Voyager 1 and 2. The instrument, consisting of two interferometers sharing a telescope and a scan mechanism, covers over a factor of 100 in wavelength in the mid and far infrared...
June 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047365/the-weight-of-work-the-association-between-maternal-employment-and-overweight-in-low-and-middle-income-countries
#16
Vanessa M Oddo, Sara N Bleich, Keshia M Pollack, Pamela J Surkan, Noel T Mueller, Jessica C Jones-Smith
BACKGROUND: Maternal employment has increased in low-and middle-income countries (LMIC) and is a hypothesized risk factor for maternal overweight due to increased income and behavioral changes related to time allocation. However, few studies have investigated this relationship in LMIC. METHODS: Using cross-sectional samples from Demographic and Health Surveys, we investigated the association between maternal employment and overweight (body mass index [BMI] ≥ 25 kg/m(2)) among women in 38 LMIC (N = 162,768)...
October 18, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29047296/in%C3%A2-vivo-13-c-mrs-in-the-mouse-brain-at-14-1-tesla-and-metabolic-flux-quantification-under-infusion-of-1-6-13-c2-glucose
#17
Marta Lai, Bernard Lanz, Carole Poitry-Yamate, Jackeline F Romero, Corina M Berset, Cristina Cudalbu, Rolf Gruetter
In vivo (13)C magnetic resonance spectroscopy (MRS) enables the investigation of cerebral metabolic compartmentation while, e.g. infusing (13)C-labeled glucose. Metabolic flux analysis of (13)C turnover previously yielded quantitative information of glutamate and glutamine metabolism in humans and rats, while the application to in vivo mouse brain remains exceedingly challenging. In the present study, (13)C direct detection at 14.1 T provided highly resolved in vivo spectra of the mouse brain while infusing [1,6-(13)C2]glucose for up to 5 h...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29046986/predictability-and-practicality-of-image-based-scoring-systems-for-patient-assessment-and-outcome-stratification-during-percutaneous-nephrolithotomy-a-contemporary-update
#18
REVIEW
Linda My Huynh, Erica Huang, Roshan M Patel, Zhamshid Okhunov
Preoperative nomograms offer systematic and quantitative methods to assess patient- and stone-related characteristics and their impact on successful treatment and potential risk of complication. Discrepancies in the correlation of perioperative variables to patient outcomes have led to the individual development, validation, and application of four independent scoring systems for the percutaneous nephrolithotomy: Guy's stone score, S.T.O.N.E. nephrolithometry, Clinical Research Office of the Endourology Society nomogram, and Seoul National University Renal Stone Complexity...
October 18, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29046735/identification-of-a-key-role-of-widespread-epigenetic-drift-in-barrett-s-esophagus-and-esophageal-adenocarcinoma
#19
E Georg Luebeck, Kit Curtius, William D Hazelton, Sean Maden, Ming Yu, Prashanthi N Thota, Deepa T Patil, Amitabh Chak, Joseph E Willis, William M Grady
BACKGROUND: Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift. However, the evolving patterns, functional consequences, and dynamics of epigenetic drift during carcinogenesis remain largely unexplored. Here we analyze the evolution of epigenetic drift patterns during progression from normal squamous esophagus tissue to Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) using 173 tissue samples from 100 (nonfamilial) BE patients, along with publically available datasets including The Cancer Genome Atlas (TCGA)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29046542/decadal-ecosystem-response-to-an-anomalous-melt-season-in-a-polar-desert-in-antarctica
#20
Michael N Gooseff, John E Barrett, Byron J Adams, Peter T Doran, Andrew G Fountain, W Berry Lyons, Diane M McKnight, John C Priscu, Eric R Sokol, Cristina Takacs-Vesbach, Martijn L Vandegehuchte, Ross A Virginia, Diana H Wall
Amplified climate change in polar regions is significantly altering regional ecosystems, yet there are few long-term records documenting these responses. The McMurdo Dry Valleys (MDV) cold desert ecosystem is the largest ice-free area of Antarctica, comprising soils, glaciers, meltwater streams and permanently ice-covered lakes. Multi-decadal records indicate that the MDV exhibited a distinct ecosystem response to an uncharacteristic austral summer and ensuing climatic shift. A decadal summer cooling phase ended in 2002 with intense glacial melt ('flood year')-a step-change in water availability triggering distinct changes in the ecosystem...
September 2017: Nature ecology & evolution
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