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Influenza ah1n1

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https://www.readbyqxmd.com/read/27816639/diminished-effector-and-memory-cd8-circulating-t-lymphocytes-in-patients-with-severe-influenza-caused-by-the-ah1n1-pdm09-virus
#1
Yolanda Gonzalez, Esmeralda Juárez, Claudia Carranza, Eduardo Sada, Sigifredo Pedraza-Sánchez, Martha Torres
The T cell immune response to viral infection includes the expansion of naïve T cells, effector cell differentiation and the induction of long-lived memory cells. We compared the differentiation of CD8(+) T cells in patients with severe or mild pneumonia induced by influenza infection occurring during the 2009 influenza outbreak and compared their T cell subsets with those in blood samples obtained from healthy volunteers before the AH1N1 influenza outbreak in Mexico. Patients with severe influenza exhibited significantly lower numbers of effector memory CD8(+)CD26 (high) CD45RO(+)CCR7(+) phenotype and lower numbers of central memory CD8(+)CD(26)(high) CD62L(+)CCR7(+), CD26 (high) CD62L(+)CD127(+) or CD26 (high) CD45RO(+)CD57 (low) phenotypes than patients with mild influenza or unexposed healthy subjects...
November 2, 2016: Virology
https://www.readbyqxmd.com/read/27561020/-clinical-features-of-patients-with-influenza-like-illness-who-went-to-a-third-level-center-in-the-winter-of-2013-2014
#2
Alejandra Albarrán-Sánchez, Claudia Ramírez-Rentería, Fernando Huerta-Montiel, Angélica Martínez-Jerónimo, Alejandro Herrera-Landero, José Luis García-Álvarez, Elia Ortiz-Rodríguez, Lorena Palmas-Pineda
BACKGROUND: Between October 2013 and April 2014, the Centers for Disease Control and Prevention reported a high incidence of AH1N1 influenza cases. Not all suspicious cases of influenza are confirmed; however, all patients need treatment and generate additional costs to the institutions. Our objective was to describe the characteristics of the patients treated for influenza suspicion at Hospital de Especialidades in Centro Médico Nacional Siglo XXI during a new epidemic. METHODS: Cross-sectional study of all cases admitted at the Emergency Service (of the aforementioned hospital) for influenza-like illness, defined according to current guidelines...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27160278/immunogenicity-and-impact-on-disease-activity-of-influenza-and-pneumococcal-vaccines-in-systemic-lupus-erythematosus-a-systematic-literature-review-and-meta-analysis
#3
Mathilde Pugès, Pascal Biscay, Thomas Barnetche, Marie-Élise Truchetet, Christophe Richez, Julien Seneschal, Noémie Gensous, Estibaliz Lazaro, Pierre Duffau
OBJECTIVES: The aim was to assess the immunogenicity and the impact on disease activity of pneumococcal and influenza vaccines in SLE patients. METHODS: We conducted a systematic literature review and meta-analysis of studies comparing the humoral response of either pneumococcal (serotype 23F) or influenza (AH1N1, AH3N2 and B strains) vaccines between SLE patients and healthy controls, assessed by a seroconversion or a seroprotection rate 3-6 weeks after vaccination...
September 2016: Rheumatology
https://www.readbyqxmd.com/read/27136236/is-sunspot-activity-a-factor-in-influenza-pandemics
#4
Jiangwen Qu
INTRODUCTION: The 2009 AH1N1 pandemic became a global health concern, although fortunately, its worst anticipated effects were not realised. While the origins of such outbreaks remain poorly understood, it is very important to identify the precipitating factors in their emergence so that future pandemics can be detected as quickly as possible. Methords: Descriptive epidemiology was used to analyse the association between influenza pandemics and possible pandemics and relative number of sunspots...
September 2016: Reviews in Medical Virology
https://www.readbyqxmd.com/read/26951014/-analysis-of-ha-and-na-genes-of-influenza-a-h1n1-virus-in-yunnan-province-during-2009-2014
#5
Juan Li, Xiaonan Zhao, Yihui Cao, Deming Ning, Xiaoqing Fu, Wen Xu
To analyze influenza pathogen spectrum in Yunnan province during 2009-2014 years, and analyze HA and NA genes of influenza A H1N1. Analysis was made on the monitoring date of influenza cases in Yunnan province in recent 6 years, 23 strains of influenza virus of HA and NA gene was sequenced and analyzed by MEGA 5 software to construct phylogenetic tree. 4 times of influenza AH1N1 epidemic peak were monitored from 2009-2014 years in Yunnan Province, as the nucleic acid detection results of influenza A H1N1 accounted for 28...
November 2015: Bing du Xue Bao, Chinese Journal of Virology
https://www.readbyqxmd.com/read/26338390/-how-did-the-media-report-on-the-ah1n1-influenza-in-peru
#6
Ada Palpan-Guerra, César V Munayco
We analyzed the characteristics of news issued by communication media (CM) in Peru on H1N1 influenza in 2013, for which written, radio, television and internet CM were reviewed daily. The news were classified according to framing, estimation (educational, informative and with high perception of risk of contagion and death) and scope. A descriptive analysis of the main variables of the study was made. The framing of the news was focused on influenza cases (47.5%) and actions of the Ministry of Health and other institutions (29...
April 2015: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/25788327/a-continuous-peptide-epitope-reacting-with-pandemic-influenza-ah1n1-predicted-by-bioinformatic-approaches
#7
Jonathan P Carrillo-Vazquez, José Correa-Basurto, Jazmin García-Machorro, Rafael Campos-Rodríguez, Violaine Moreau, Jorge L Rosas-Trigueros, Cesar A Reyes-López, Marlon Rojas-López, Absalom Zamorano-Carrillo
Computational identification of potential epitopes with an immunogenic capacity challenges immunological research. Several methods show considerable success, and together with experimental studies, the efficiency of the algorithms to identify potential peptides with biological activity has improved. Herein, an epitope was designed by combining bioinformatics, docking, and molecular dynamics simulations. The hemagglutinin protein of the H1N1 influenza pandemic strain served as a template, owing to the interest of obtaining a scheme of immunization...
September 2015: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/25559047/modelling-influenza-a-h1n1-2009-epidemics-using-a-random-network-in-a-distributed-computing-environment
#8
Gilberto González-Parra, Rafael-J Villanueva, Javier Ruiz-Baragaño, Jose-A Moraño
In this paper we propose the use of a random network model for simulating and understanding the epidemics of influenza A(H1N1). The proposed model is used to simulate the transmission process of influenza A(H1N1) in a community region of Venezuela using distributed computing in order to accomplish many realizations of the underlying random process. These large scale epidemic simulations have recently become an important application of high-performance computing. The network model proposed performs better than the traditional epidemic model based on ordinary differential equations since it adjusts better to the irregularity of the real world data...
March 2015: Acta Tropica
https://www.readbyqxmd.com/read/24779221/-influenza-infection-in-intensive-cardiac-care-unit-patients
#9
REVIEW
Katrzyna Ciuraszkiewicz, Janusz Sielski, Agnieszka Janion-Sadowska, Agnieszka Stern, Joanna Zychowicz, Karol Kaziród-Wolski, Marian Paluchowski
Infection with influenza type A virus may cause serious cardiovascular complications, such as myocarditis, heart failure, acute myocardial infarction. Also infection with influenza type AH1N1 may contribute to aggravation of cardiac disorders, i.e. acute coronary syndrome, heart failure, cardiogenic shock, severe ventricular arrythmias. One of the most fatal complication of influenza is pneumonia leading to acute respiratory insufficiency requiring artifitial ventilation. Symptoms of respiratory tract infections durnig influenza epidemy should always be treated with a high index of suspicion...
March 2014: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/24643021/pregnancy-related-h1n1-influenza-and-severe-acute-respiratory-distress-syndrome-successfully-treated-with-extracorporeal-membrane-oxygenation-despite-difficult-vascular-access
#10
Bożena Seczyńska, Miłosz Jankowski, Ilona Nowak, Wojciech Szczeklik, Konstanty Szułdrzyński, Wiesław Królikowski
No abstract text is available yet for this article.
2014: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/24304728/-flu-symptoms-and-preventive-measures-practiced-by-the-inhabitants-of-mexico-city-during-the-ah1n1-influenza-epidemic
#11
Verónica Cruz-Licea, Fernando González-Domínguez, Guillermina Avila, Ana Flisser
OBJECTIVE: To know the frequency of flu symptoms and describe preventive measures practiced by the inhabitants of Mexico City during the AH1N1 epidemic. MATERIAL AND METHODS: A cross-sectional design was used and a survey containing demographic and health information was conducted in August and September 2009 in a sample of 4003 randomly selected people living in Mexico City. RESULTS: Referred flu symptoms were: 29% running nose, 25% cough, 25% throat infection, 17% muscle and joint pain, 10% respiratory problems, and 7% fever...
July 2013: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/24146347/chronic-inflammatory-demyelinating-polyradiculoneuropathy-cidp-associated-to-hereditary-neuropathy-with-liability-to-pressure-palsies-hnpp-and-revealed-after-influenza-ah1n1-vaccination
#12
Gauthier Remiche, Marc Abramowicz, Nicolas Mavroudakis
Neurological complications of AH1N1 vaccination such as Guillain-Barré syndrome were described in the previous years. Several reports suggest that hereditary neuropathies may be a predisposing factor for immune-mediated neuropathies. We report the case of a 54-year-old female who developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) 5 weeks after AH1N1 vaccination. She had no previous neurological history, but neurophysiological features led us to suspect an underlying hereditary neuropathy...
December 2013: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/23930018/molecular-distribution-of-amino-acid-substitutions-on-neuraminidase-from-the-2009-h1n1-human-influenza-pandemic-virus
#13
Miguelmiguel Quiliano, Hugo Valdivia-Olarte, Carlos Olivares, David Requena, Andrés H Gutiérrez, Paola Reyes-Loyola, Luis E Tolentino-Lopez, Patricia Sheen, Verónica Briz, Maria A Muñoz-Fernández, José Correa-Basurto, Mirko Zimic
The pandemic influenza AH1N1 (2009) caused an outbreak of human infection that spread to the world. Neuraminidase (NA) is an antigenic surface glycoprotein, which is essential to the influenza infection process, and is the target of anti-flu drugs oseltamivir and zanamivir. Currently, NA inhibitors are the pillar pharmacological strategy against seasonal and global influenza. Although mutations observed after NA-inhibitor treatment are characterized by changes in conserved amino acids of the enzyme catalytic site, it is possible that specific amino acid substitutions (AASs) distant from the active site such as H274Y, could confer oseltamivir or zanamivir resistance...
2013: Bioinformation
https://www.readbyqxmd.com/read/23844285/mortality-associated-with-influenza-in-tropics-state-of-s%C3%A3-o-paulo-brazil-from-2002-to-2011-the-pre-pandemic-pandemic-and-post-pandemic-periods
#14
André Ricardo Ribas Freitas, Priscila M S Bergamo Francisco, Maria Rita Donalisio
The impact of the seasonal influenza and 2009 AH1N1 pandemic influenza on mortality is not yet completely understood, particularly in tropical and subtropical countries. The trends of influenza related mortality rate in different age groups and different outcomes on a area in tropical and subtropical climate with more than 41 million people (State of São Paulo, Brazil), were studied from 2002 to 2011 were studied. Serfling-type regression analysis was performed using weekly mortality registries and virological data obtained from sentinel surveillance...
2013: Influenza Research and Treatment
https://www.readbyqxmd.com/read/23763223/an-unexpected-cause-of-diarrhea-in-a-pregnant-patient-a-case-report
#15
Michelle Villar-Díaz, Miguel Vázquez-Guzmán, Edgardo Rivera Rosa, Josefina Romaguera, Pérez Iehsus Flores
In 2009 AH1N1, a novel influenza virus was identified. Majority of complications arise in specific group of patient including pregnant women. This report is a description of the first patient encountered in our institution. Such case was a yo woman on the 23rd week of gestation that presented with several episodes of diarrhea. Shortly after admission what appeared to be a common case of gastroenteritis evolved in respiratory distress and hemodynamic instability progressing to respiratory distress syndrome. The diagnosis was delayed by the absence of respiratory symptoms at presentation as well as by the lack of rapid specific laboratories...
September 2012: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/23695369/vaccination-herd-behavior-and-herd-immunity
#16
Matan J Cohen, Mayer Brezis, Colin Block, Adele Diederich, David Chinitz
BACKGROUND: During the 2009 outbreak of novel influenza AH1N1, insufficient data were available to adequately inform decision makers about benefits and risks of vaccination and disease. We hypothesized that individuals would opt to mimic their peers, having no better decision anchor. We used Game Theory, decision analysis, and transmission models to simulate the impact of subjective risks and preference estimates on vaccination behavior. METHODS: We asked 95 students to provide estimates of risk and health state valuations with regard to AH1N1 infection, complications, and expectations of vaccine benefits and risks...
November 2013: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/23422930/potentially-toxic-and-essential-elements-profile-of-ah1n1-patients-in-mexico-city
#17
Mireya Moya, Edgar G Bautista, Antonio Velázquez-González, Felipe Vázquez-Gutiérrez, Guadalupe Tzintzun, María Elena García-Arreola, Manuel Castillejos, Andrés Hernández
During spring of 2009, a new influenza virus AH1N1 spread in the world causing acute respiratory illness and death, resulting in the first influenza pandemic since 1968. Blood levels of potentially-toxic and essential elements of 40 pneumonia and confirmed AH1N1 were evaluated against two different groups of controls, both not infected with the pandemic strain. Significant concentrations of potentially-toxic elements (lead, mercury, cadmium, chromium, arsenic) along with deficiency of selenium or increased Zn/Cu ratios characterized AH1N1 cases under study when evaluated versus controlled cases...
2013: Scientific Reports
https://www.readbyqxmd.com/read/23371837/theoretical-analysis-of-the-neuraminidase-epitope-of-the-mexican-a-h1n1-influenza-strain-and-experimental-studies-on-its-interaction-with-rabbit-and-human-hosts
#18
Paola Kinara Reyes Loyola, R Campos-Rodríguez, Martiniano Bello, S Rojas-Hernández, Mirko Zimic, Miguel Quiliano, Verónica Briz, M Angeles Muñoz-Fernández, Luis Tolentino-López, Jose Correa-Basurto
The neuraminidase (NA) epitope from the Mexican AH1N1 influenza virus was identified by using sequences registered at the GenBank during the peak of a pandemic (from April 2009 to October 2010). First, NA protein sequences were submitted for multiple alignment analysis, and their three-dimensional models (3-D) were then built by using homology modeling. The most common sequence (denominated wild-type) and its mutants were submitted to linear and nonlinear epitope predictors, which included the major histocompatibility complex type II (MHC II) and B-cell peptides...
May 2013: Immunologic Research
https://www.readbyqxmd.com/read/23256776/occurrence-of-ah1n1-viral-infection-and-clinical-features-in-symptomatic-patients-who-received-medical-care-during-the-2009-influenza-pandemic-in-central-mexico
#19
Juan Pablo Castillo-Palencia, Lucie Laflamme, Joel Monárrez-Espino
BACKGROUND: In 2009 a new influenza serotype (AH1N1) was identified in Mexico that spread rapidly generating worldwide alarm. San Luis Potosi (SLP) was the third state with more cases reported in that year. The clinical identification of this flu posed a challenge to medical staff. This study aimed at estimating the AH1N1 infection, hospitalization and mortality rates, and at identifying related clinical features in persons who received medical care during the influenza pandemic. METHODS: Retrospective study with persons with flu-like illness who received public or private medical care in SLP from 15...
2012: BMC Infectious Diseases
https://www.readbyqxmd.com/read/23122940/-criteria-of-the-patient-s-decision-concerning-vaccination-against-influenza-ah1n1-in-belgium-and-france
#20
Frédéric Ketterer, Yves Goffin, Pierre Boyer, Anne Freyens, Adeline Sourbes, Jean-Luc Belche, Didier Giet
INTRODUCTION: We have analyzed the reasons evoked by the patients to decide or not to be vaccinated against AH1N1 influenza, in France and Belgium. METHODS: Semi-structured interviews were performed, recorded and transcribed for analysis. Fifty-eight interviews were performed with patient living in the region of Midi-Pyrénées, France (21 interviews) and in the province of Liège, Belgium (37 interviews). The patients were recruited by general practitioners. Within the sample, some patients were vaccinated against AH1N1 influenza and others were not...
March 2013: La Presse Médicale
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