Yi Li, Jose L Mondaza-Hernandez, David S Moura, Alexey S Revenko, Angelica Tolentino, John T Nguyen, Nam Tran, Clark A Meyer, Jose Merino-Garcia, Rafael Ramos, Davide Di Lernia, Javier Martin-Broto, Heather N Hayenga, Leonidas Bleris
Solitary fibrous tumor (SFT) is a rare, non-hereditary soft tissue sarcoma thought to originate from fibroblastic mesenchymal stem cells. The etiology of SFT is thought to be due to an environmental intrachromosomal gene fusion between NGFI-A-binding protein 2 (NAB2) and signal transducer and activator protein 6 (STAT6) genes on chromosome 12, wherein the activation domain of STAT6 is fused with the DNA-binding domain of NAB2 resulting in the oncogenesis of SFT. All NAB2-STAT6 fusion variations discovered in SFTs contain the C-terminal of STAT6 transcript, and thus can serve as target site for antisense oligonucleotides (ASOs)-based therapies...
June 11, 2024: Molecular Therapy. Nucleic Acids