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https://www.readbyqxmd.com/read/29351260/fatty-acid-based-microemulsions-to-combat-ophthalmia-neonatorum-caused-by-neisseria-gonorrhoeae-and-staphylococcus-aureus
#1
Ummara Butt, Amr ElShaer, Lori A S Snyder, Ali A Al-Kinani, Adam Le Gresley, Raid G Alany
The bacterial species Neisseria gonorrhoeae (N. gonorrhoeae) and Staphylococcus aureus (S. aureus) are amongst the main microorganisms that cause ophthalmia neonatorum. The current treatment involves the use of various antibiotics such as ciprofloxacin, cephalosporin, ceftriaxone and cefotaxime. However, this treatment strategy is becoming more ineffective due to the antibiotic resistance in N. gonorrhoeae. The current study explores the potential use of fatty acid based microemulsions (ME) to prevent N. gonorrhoeae and S...
January 19, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29351089/aggressive-variants-of-papillary-thyroid-carcinoma-hobnail-tall-cell-columnar-and-solid
#2
Meryl C Nath, Lori A Erickson
Papillary thyroid carcinomas are the most common endocrine cancer and are usually associated with good survival. However, some variants of papillary thyroid carcinomas may behave more aggressively than classic papillary thyroid carcinomas. The tall cell variant of papillary thyroid carcinoma is the most common aggressive variant of papillary thyroid carcinoma. The aggressive behavior has been ascribed to the histologic subtype and/or to the clinicopathologic features, an issue that remains controversial. The columnar variant of papillary thyroid carcinoma can be aggressive, particularly in older patients, with larger tumors showing a diffusely infiltrative growth pattern and extrathyroidal extension...
January 18, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29350494/sleep-disruption-in-caregivers-of-pediatric-stem-cell-recipients
#3
Kristen Coleman, Laura Flesch, Lisa Petiniot, Abigail Pate, Li Lin, Lori Crosby, Dean W Beebe, Adam Nelson, Priscila Badia Alonso, Stella M Davies, Rachel B Baker, Christopher E Dandoy
Parents/caregivers of hospitalized patients are at risk of sleep disruption. We performed a cross-sectional quantitative and qualitative evaluation of sleep in parents/caregivers of children undergoing hematopoietic stem cell transplant (HSCT; n = 17). Additionally, we explored the frequency of room entries for hospitalized patients undergoing HSCT (n = 189 nights). Twelve caregivers (71%) demonstrated significant sleep disturbance, 12 (71%) described sleep quality as poor, 15 (88%) averaged < 6 hours of sleep per night, 14 (82%) awakened at least four times per night...
January 19, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29350400/feasibility-of-enteral-protein-supplementation-in-critically-ill-children
#4
Yara M F Moreno, Daniela B Hauschild, Mayara D Martins, Lori J Bechard, Nilesh M Mehta
BACKGROUND: We describe the protein type and concentration in standard enteral nutrition (EN) formulas and the effect of protein supplementation on the osmolality of standard formulas. We also aimed to examine factors associated with optimal protein delivery in critically ill children. METHODS: Protein content and other characteristics of pediatric EN formulas used worldwide were recorded. Factors associated with achievement of recommended protein delivery and tolerance of protein-supplemented formulas were recorded prospectively in a cohort of critically ill children...
January 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29349695/efficacy-of-atopy-patch-testing-in-directed-dietary-therapy-of-eosinophilic-esophagitis-a-pilot-study
#5
Jason D Eckmann, Karthik Ravi, David A Katzka, Dawn R Davis, Jacalyn A See, Debra R Geno, Lori A Kryzer, Jeffrey A Alexander
BACKGROUND: Atopy patch testing (APT) has shown potential for predicting dietary food triggers in studies of children and adolescents with eosinophilic esophagitis (EoE). AIMS: To assess the efficacy of APT in adults with EoE. METHODS: We conducted a prospective open-label pilot study of patients ≥ 18 years old with diagnosis of EoE at Mayo Clinic in Rochester, Minnesota, from November 2014 to January 2016. All patients underwent patch testing using intact food products, followed by a six food elimination diet and stepwise food reintroduction...
January 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29346744/2017-national-standards-for-diabetes-self-management-education-and-support
#6
Joni Beck, Deborah A Greenwood, Lori Blanton, Sandra T Bollinger, Marcene K Butcher, Jo Ellen Condon, Marjorie Cypress, Priscilla Faulkner, Amy Hess Fischl, Theresa Francis, Leslie E Kolb, Jodi M Lavin-Tompkins, Janice MacLeod, Melinda Maryniuk, Carolé Mensing, Eric A Orzeck, David D Pope, Jodi L Pulizzi, Ardis A Reed, Andrew S Rhinehart, Linda Siminerio, Jing Wang
Purpose The purpose of this study is to review the literature for Diabetes Self-Management Education and Support (DSMES) to ensure the National Standards for DSMES (Standards) align with current evidence-based practices and utilization trends. Methods The 10 Standards were divided among 20 interdisciplinary workgroup members. Members searched the current research for diabetes education and support, behavioral health, clinical, health care environment, technical, reimbursement, and business practice for the strongest evidence that guided the Standards revision...
February 2018: Diabetes Educator
https://www.readbyqxmd.com/read/29344582/factor-xiii-in-plasma-but-not-in-platelets-mediates-red-blood-cell-retention-in-clots-and-venous-thrombus-size-in-mice
#7
Sravya Kattula, James R Byrnes, Sara M Martin, Lori A Holle, Brian C Cooley, Matthew J Flick, Alisa S Wolberg
The transglutaminase factor XIII (FXIII) stabilizes clots against mechanical and biochemical disruption and is essential for hemostasis. In vitro and in vivo models of venous thrombosis demonstrate that FXIII mediates clot size by promoting red blood cell (RBC) retention. However, the key source of FXIII and whether FXIII activity can be reduced to suppress thrombosis without imposing deleterious hemostatic consequences are 2 critical unresolved questions. FXIII is present in multiple compartments, including plasma (FXIIIplasma) as a heterotetramer of A2 and B2 subunits and platelets (FXIIIplt) as an A2 homodimer...
January 9, 2018: Blood Advances
https://www.readbyqxmd.com/read/29344578/a-practical-approach-to-using-trend-arrows-on-the-dexcom-g5-cgm-system-to-manage-children-and-adolescents-with-diabetes
#8
Lori M Laffel, Grazia Aleppo, Bruce A Buckingham, Gregory P Forlenza, Lisa E Rasbach, Eva Tsalikian, Stuart A Weinzimer, Dennis R Harris
After assessing previously published methods, we developed a practical approach to adjusting insulin doses using rtCGM trend arrows in pediatric patients with diabetes.
December 1, 2017: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29344577/a-practical-approach-to-using-trend-arrows-on-the-dexcom-g5-cgm-system-for-the-management-of-adults-with-diabetes
#9
Grazia Aleppo, Lori M Laffel, Andrew J Ahmann, Irl B Hirsch, Davida F Kruger, Anne Peters, Ruth S Weinstock, Dennis R Harris
After reviewing previously published methods, we developed a practical approach to adjusting insulin doses based on insulin sensitivity for adult patients with diabetes using rtCGM trend arrow data.
December 1, 2017: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29342354/a-highly-dynamic-loop-of-the-pseudomonas-aeruginosa-pa14-type-iv-pilin-is-essential-for-pilus-assembly
#10
Ylan Nguyen, Stephen Boulton, E Tyler McNicholl, Madoka Akimoto, Hanjeong Harvey, Francisca Aidoo, Giuseppe Melacini, Lori L Burrows
Type IVa pili (T4aP) are long, thin surface filaments involved in attachment, motility, biofilm formation, and DNA uptake. They are important virulence factors for many bacteria, including Pseudomonas aeruginosa, an opportunistic pathogen and common cause of hospital-acquired infections. Each helical filament contains thousands of monomers of the major pilin subunit, PilA. Each P. aeruginosa strain expresses one of five phylogenetically distinct major pilins, which vary in sequence and the nature of their associated accessory protein(s)...
January 17, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29339539/the-hippo-pathway-component-taz-promotes-immune-evasion-in-human-cancer-through-pd-l1
#11
Helena J Janse van Rensburg, Taha Azad, Min Ling, Yawei Hao, Brooke Snetsinger, Prem Khanal, Lori M Minassian, Charles H Graham, Michael J Rauh, Xiaolong Yang
The Hippo pathway component WW domain-containing transcription regulator 1 (TAZ) is a transcriptional co-activator and an oncogene in breast and lung cancer. Transcriptional targets of TAZ that modulate immune cell function in the tumour microenvironment are poorly understood. Here, we perform a comprehensive screen for immune-related genes regulated by TAZ and its paralog YAP using NanoString gene expression profiling. We identify the immune checkpoint molecule PD-L1 as a target of Hippo signaling. The upstream kinases of the Hippo pathway, mammalian STE20-like kinase 1 and 2 (MST1/2) and large tumour suppressor 1 and 2 (LATS1/2), suppress PD-L1 expression while TAZ and YAP enhance PD-L1 levels in breast and lung cancer cell lines...
January 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29338846/comparison-of-two-trunk-electromagnetic-sensor-placement-methods-during-shoulder-motion-analysis
#12
Hillary A Plummer, Federico Pozzi, Lori A Michener
For kinematic studies of the shoulder, electromagnetic sensors are commonly placed on the humerus, scapula, and trunk. The trunk sensor is used to describe humeral and scapular kinematics with respect to the trunk. There are two common trunk sensor placements, the sternum or third thoracic vertebrae (T3). It is currently unclear if placement of the trunk sensor affects kinematics, making it difficult to compare data across studies. The purpose of this study was to compare two trunk sensor placements (T3 and sternum) on trunk and scapular kinematics during arm elevation...
December 24, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29336999/faculty-relative-value-unit-incentives-and-resident-education
#13
Lori A Deitte, Carolyn C Meltzer, Alexander Norbash, Mary C Mahoney, Jorge A Soto, Priscilla J Slanetz
No abstract text is available yet for this article.
January 11, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29336970/a-nasal-ventilation-mask-for-a-morbidly-obese-patient-with-osa-and-atrial-fibrillation-undergoing-cardioversion
#14
Rachel Kozinn, James Kim, Lori Kwan, Jessica Feinleib
No abstract text is available yet for this article.
May 25, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29336024/facility-and-state-variation-in-hip-fracture-in-u-s-nursing-home-residents
#15
Andrew R Zullo, Tingting Zhang, Geetanjoli Banerjee, Yoojin Lee, Kevin W McConeghy, Douglas P Kiel, Lori A Daiello, Vincent Mor, Sarah D Berry
OBJECTIVES: To quantify the variation in hip fracture incidence across U.S. nursing home (NH) facilities and states and examine how hip fracture incidence varies according to facility- and state-level characteristics. DESIGN: Retrospective cohort using linked national Minimum Data Set assessments; Online Survey, Certification and Reporting records; and Medicare claims. SETTING: U.S. NHs with 100 or more beds. PARTICIPANTS: Long-stay NH residents between May 1, 2007, and April 30, 2008, from 1,481 facilities and 46 U...
January 16, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29335183/microwave-assisted-synthesis-of-palladium-nanoparticles-intercalated-nitrogen-doped-reduced-graphene-oxide-and-their-electrocatalytic-activity-for-direct-ethanol-fuel-cells
#16
Rajesh Kumar, Everson T S G da Silva, Rajesh K Singh, Raluca Savu, Andrei V Alaferdov, Leandro C Fonseca, Lory C Carossi, Arvind Singh, Sarita Khandka, Kamal K Kar, Oswaldo L Alves, Lauro T Kubota, Stanislav A Moshkalev
Palladium nanoparticles decorated reduced graphene oxide (Pd-rGO) and palladium nanoparticles intercalated inside nitrogen doped reduced graphene oxide (Pd-NrGO) hybrids have been synthesized by applying a very simple, fast and economic route using microwave-assisted in-situ reduction and exfoliation method. The Pd-NrGO hybrids materials show good activity as catalyst for ethanol electro oxidation for direct ethanol fuel cells (DEFCs) as compared to Pd-rGO hybrids. The enhanced direct ethanol fuel cell can serve as alternative to fossil fuels because it is renewable and environmentally-friendly with a high energy conversion efficiency and low pollutant emission...
January 8, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29334881/a-proactive-behavioral-health-service-model-to-address-use-of-constant-observation-in-a-general-hospital
#17
Aaron Pinkhasov, Deepan Singh, Sridivya Chavali, Lori Legrand, Rose Calixte
In hospitals, use of constant observation (CO) causes significant economic burden without demonstrated reduction in adverse events. A novel quality improvement (QI) project was developed to reduce use of CO by integrating proactive behavioral health management of all patients requiring CO in a general hospital. Specific nonpharmacologic and pharmacologic interventions used in this project, which included 491 patients, are discussed. Data collected were compared with data from a baseline period before project implementation...
January 16, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29334760/polymorphisms-in-estrogen-synthesis-genes-and-symptom-clusters-during-the-menopausal-transition-and-early-postmenopause-observations-from-the-seattle-midlife-women-s-health-study
#18
Nancy Fugate Woods, Lori A Cray, Ellen Sullivan Mitchell, Fred Farrin, Jerald Herting
During the menopausal transition and early postmenopause, participants in the Seattle Midlife Women's Health Study (SMWHS) experienced one of the three symptom severity clusters identified through latent class analysis: severe hot flashes with moderate sleep, mood, cognitive, and pain symptoms (high-severity hot flash); low-severity hot flashes with moderate levels of all other symptom groups (moderate severity); and low levels of all symptom groups (low severity). In an effort to determine whether gene polymorphisms were associated with these symptom severity classes, we tested associations between gene polymorphisms in the estrogen synthesis pathways (cytochrome P450 19 [CYP 19] and 17 beta hydroxysteroid dehydrogenase [ 17HSDB1]) and the three symptom severity clusters...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29334567/pediatric-vascular-trauma-practice-patterns-and-resource-availability-a-survey-of-acs-designated-pediatric-trauma-centers
#19
Patrick C Bonasso, Lori A Gurien, Samuel D Smith, Marie E Saylors, M Sidney Dassinger
BACKGROUND: Variation exists in pediatric vascular trauma management. We aim to determine practice patterns for vascular trauma management at American College of Surgeons (ACS) verified pediatric trauma centers and evaluate the resources available for management of vascular trauma at both freestanding children's hospitals (FSCH) and pediatric hospitals within general adult hospitals (PHGAH). METHODS: Pediatric surgeons and trauma medical directors at ACS designated pediatric surgery trauma centers completed a survey designed to evaluate anticipated management of traumatic arterial injuries and resource availability...
January 12, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29334260/crude-extract-of-origanum-vulgare-l-induced-cell-death-and-suppressed-mapk-and-pi3-akt-signaling-pathways-in-sw13-and-h295r-cell-lines
#20
Beatrice Rubin, Jacopo Mansi, Halenya Monticelli, Loris Bertazza, Marco Redaelli, Francesca Sensi, Maira Zorzan, Carla Scaroni, Caterina Mian, Maurizio Iacobone, Decio Armanini, Cristina Bertolini, Susi Barollo, Marco Boscaro, Raffaele Pezzani
Oregano (Origanum vulgare L.) is a common aromatic plant used in Mediterranean and Asian Regions for treating respiratory diseases, painful menstruation, rheumatoid arthritis, etc. Recently its role as an anticancer plant has been suggested, although oregano has been never evaluated into adrenocortical tumour cell models. This study analysed for the first time the anticancer effects of a crude extract of wild mountain oregano (Origanum vulgare L.) in SW13 and H295R cell lines. The crude extract was characterised by GC/MS and the toxic effects of oregano were first analysed by brine shrimp lethality assay...
January 15, 2018: Natural Product Research
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