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https://www.readbyqxmd.com/read/29792280/resource-utilization-and-indications-for-helicopter-transport-of-head-injured-children
#1
Clay M Elswick, Deidre Wyrick, Lori A Gurien, Malik Rettiganti, Marie Gowen, Ambre' Pownall, Diaa Bahgat, R Todd Maxson, Eylem Öcal, Gregory W Albert
INTRODUCTION: Helicopter emergency medical services (HEMS) have provided benefit for severely injured patients. However, HEMS are likely overused for the transportation of both adult and pediatric trauma patients. In this study, we aim to evaluate the degree of overuse of helicopter as a mode of transport for head-injured children. In addition, we propose criteria that can be used to determine if a particular patient is suitable for air versus ground transport. MATERIALS AND METHODS: We identified patients who were transported to our facility for head injuries...
May 1, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29790589/genotype-phenotype-correlation-of-hereditary-erythrocytosis-mutations-a-single-center-experience
#2
Jennifer L Oliveira, Lea M Coon, Lori A Frederick, Molly Hein, Kenneth C Swanson, Michelle E Savedra, Tavanna R Porter, Mrinal M Patnaik, Ayalew Tefferi, Animesh Pardanani, Stefan K Grebe, David S Viswanatha, James D Hoyer
Hereditary erythrocytosis is associated with high oxygen affinity hemoglobin variants (HOAs), 2,3-bisphosphoglycerate deficiency and abnormalities in EPOR and the oxygen-sensing pathway proteins PHD, HIF2α, and VHL. Our laboratory has 40 years of experience with hemoglobin disorder testing and we have characterized HOAs using varied protein and molecular techniques including functional assessment by p50 analysis. In addition, we have more recently commenced adding the assessment of clinically relevant regions of the VHL, BPGM, EPOR, EGLN1 (PHD2), and EPAS1 (HIF2A) genes in a more comprehensive hereditary erythrocytosis panel of tests...
May 23, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29790058/the-synergistic-effect-of-organic-acids-phytochemicals-and-a-permeabilizing-complex-reduces-salmonella-typhimurium-1-4-5-12-i-shedding-in-pigs
#3
Ruggeri Jessica, Foresti Fabio, Pavesi Roberta, Terrini Alessia, Giudici Francesca, Padoan Diego, Corradi Attilio, Ossiprandi Maria Cristina, Pasquali Paolo, Alborali Giovanni Loris
Salmonella Typhimurium (including S.Typhimurium 1,4,[5],12:i-) and other enteric pathogens cause acute infection in pigs during the weaning stage, often evolving into chronic infections responsible for the introduction of zoonotic bacteria into the slaughterhouse and thus determining carcass contamination. In addition to being zoonotic hazards, these pathogens are responsible for economic losses in affected farms. Traditionally, antibiotic treatments have been largely administered in order to reduce the infection burden but it favored, as a direct consequence, an increase in the number of multi-drug resistance strains...
May 22, 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29789573/high-throughput-screening-of-prostate-cancer-risk-loci-by-single-nucleotide-polymorphisms-sequencing
#4
Peng Zhang, Ji-Han Xia, Jing Zhu, Ping Gao, Yi-Jun Tian, Meijun Du, Yong-Chen Guo, Sufyan Suleman, Qin Zhang, Manish Kohli, Lori S Tillmans, Stephen N Thibodeau, Amy J French, James R Cerhan, Li-Dong Wang, Gong-Hong Wei, Liang Wang
Functional characterization of disease-causing variants at risk loci has been a significant challenge. Here we report a high-throughput single-nucleotide polymorphisms sequencing (SNPs-seq) technology to simultaneously screen hundreds to thousands of SNPs for their allele-dependent protein-binding differences. This technology takes advantage of higher retention rate of protein-bound DNA oligos in protein purification column to quantitatively sequence these SNP-containing oligos. We apply this technology to test prostate cancer-risk loci and observe differential allelic protein binding in a significant number of selected SNPs...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29789370/a-single-domain-response-regulator-functions-as-an-integrating-hub-to-coordinate-general-stress-response-and-development-in-alphaproteobacteria
#5
C Lori, A Kaczmarczyk, I de Jong, U Jenal
The alphaproteobacterial general stress response is governed by a conserved partner-switching mechanism that is triggered by phosphorylation of the response regulator PhyR. In the model organism Caulobacter crescentus , PhyR was proposed to be phosphorylated by the histidine kinase PhyK, but biochemical evidence in support of such a role of PhyK is missing. Here, we identify a single-domain response regulator, MrrA, that is essential for general stress response activation in C. crescentus We demonstrate that PhyK does not function as a kinase but accepts phosphoryl groups from MrrA and passes them on to PhyR, adopting the role of a histidine phosphotransferase...
May 22, 2018: MBio
https://www.readbyqxmd.com/read/29788418/efficacy-of-bezlotoxumab-based-on-timing-of-administration-relative-to-start-of-antibacterial-therapy-for-clostridium-difficile-infection
#6
Thomas Birch, Yoav Golan, Giuliano Rizzardini, Erin Jensen, Lori Gabryelski, Dalya Guris, Mary Beth Dorr
Background: The fully human monoclonal antibody bezlotoxumab binds Clostridioides (Clostridium) difficile toxin B and reduces recurrence rates in patients with C. difficile infection (CDI) receiving antibacterial treatment for a primary or recurrent episode. Objectives: To investigate whether the timing of bezlotoxumab administration relative to the onset of antibacterial treatment affected clinical outcome in the Phase 3 trials MODIFY I (NCT01241552) and MODIFY II (NCT01513239)...
May 16, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29788327/tree-ring-proxies-of-larch-bud-moth-defoliation-latewood-width-and-blue-intensity-are-more-precise-than-tree-ring-width
#7
Estelle Arbellay, Ingrid Jarvis, Raphaël D Chavardès, Lori D Daniels, Markus Stoffel
Reconstructions of defoliation by larch bud moth (LBM, Zeiraphera diniana Gn.) based on European larch (Larix decidua Mill.) tree rings have unraveled outbreak patterns over exceptional temporal and spatial scales. In this study, we conducted tree-ring analyses on 105 increment cores of European larch from the Valais Alps, Switzerland. The well-documented history of LBM outbreaks in Valais provided a solid baseline for evaluating the LBM defoliation signal in multiple tree-ring parameters. First, we used tree-ring width measurements along with regional records of LBM outbreaks to reconstruct the occurrence of these events at two sites within the Swiss Alps...
May 19, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29788266/dietary-magnesium-alleviates-experimental-murine-colitis-through-upregulation-of-the-transient-receptor-potential-melastatin-6-channel
#8
Valentina Trapani, Valentina Petito, Angelica Di Agostini, Daniela Arduini, Willem Hamersma, Giuseppe Pietropaolo, Francesca Luongo, Vincenzo Arena, Egidio Stigliano, Loris R Lopetuso, Antonio Gasbarrini, Federica I Wolf, Franco Scaldaferri
Background: Magnesium (Mg) is essential for human health and is absorbed mainly in the intestine. In view of the likely occurrence of an Mg deficit in inflammatory bowel disease (IBD) and the documented role of Mg in modulating inflammation, the present study addresses whether Mg availability can affect the onset and progression of intestinal inflammation. Methods: To study the correlation between Mg status and disease activity, we measured magnesemia by atomic absorption spectroscopy in a cohort of IBD patients...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29781454/nurse-navigator-core-competencies-an-update-to-reflect-the-evolution-of-the-role
#9
Kristen Baileys, Lori McMullen, Barbara Lubejko, Deborah Christensen, Pamela J Haylock, Traudi Rose, Jean Sellers, Dominique Srdanovic
BACKGROUND: The Oncology Nursing Society published Oncology Nurse Navigator (ONN) Core Competencies in 2013. However, a 2016 role delineation study (RDS) indicated that the role had evolved since their release. The RDS also indicated that a growing number of nurse navigators have extensive oncology and navigation experience. OBJECTIVES: The update to the competencies was undertaken to identify current responsibilities of ONNs and differentiate novice from expert practice...
June 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29781350/on-line-ethics-education-for-occupational-therapy-clinician-educators-a-single-group-pre-post-test-study
#10
Sandra VanderKaay, Lori Letts, Bonny Jung, Sandra E Moll
PURPOSE: Ethics education is a critical component of training rehabilitation practitioners. There is a need for capacity-building among ethics educators regarding facilitating ethical decision-making among students. The purpose of this study was to evaluate the utility of an on-line ethics education module for occupational therapy clinician-educators (problem-based learning tutors/clinical placement preceptors/evidence-based practice facilitators). METHOD: The Knowledge-to-Action Process informed development and evaluation of the module...
May 20, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29778950/efficacy-of-educational-intervention-to-improve-awareness-of-the-importance-of-iodine-use-of-iodized-salt-and-dietary-iodine-intake-in-northeastern-italian-schoolchildren
#11
Sara Watutantrige-Fernando, Susi Barollo, Loris Bertazza, Elisabetta Cavedon, Simona Censi, Jacopo Manso, Federica Vianello, Caterina Mian
OBJECTIVE: An educational program was conducted among school-aged children to improve their knowledge about iodine prophylaxis, their iodine status, and their dietary habits. METHODS: At the baseline (T0) and after 6 mo (T1), participants (970 at T0 and 949 at T1) answered questionnaires testing their knowledge about iodine prophylaxis and their eating habits. Urine samples were collected from a randomly selected subgroup of participants (313 at T0 and 312 at T1)...
March 23, 2018: Nutrition
https://www.readbyqxmd.com/read/29778516/facilitators-of-and-barriers-to-hpv-vaccination-among-sexual-and-gender-minority-patients-at-a-boston-community-health-center
#12
Kaan Z Apaydin, Holly B Fontenot, Derri Shtasel, Sannisha K Dale, Christina P C Borba, Christopher S Lathan, Lori Panther, Kenneth H Mayer, Alex S Keuroghlian
BACKGROUND: Young sexual minority individuals have lower human papillomavirus (HPV) vaccine completion rates than the general population, and little is known about how gender minority people perceive HPV vaccination. The aim of this study was to qualitatively identify patient-, provider-, and systems-level barriers and facilitators for HPV vaccination among sexual and gender minority (SGM) people. METHODS: Fifteen SGM-identified individuals, ages 23-26, were recruited at an urban community health center in Boston, MA, that specializes in care for SGM...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29778510/assessment-of-intestinal-failure-associated-liver-disease-according-to-different-diagnostic-criteria
#13
Anna Simona Sasdelli, Federica Agostini, Caterina Pazzeschi, Mariacristina Guidetti, Simon Lal, Loris Pironi
BACKGROUND & AIMS: Intestinal failure associated liver disease (IFALD) has been defined using numerous criteria; however the clinical relevance of these criteria has never been compared. We therefore aimed to evaluate the prevalence, incidence, evolution of IFALD diagnosed by different criteria and to assess any clinical features that may be associated with its occurrence. METHODS: A cross sectional (CS) and retrospective study were carried out on adults on home parenteral nutrition (HPN) for chronic intestinal failure (CIF) managed at a single center...
May 8, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29776610/comparative-evaluation-of-immune-responses-of-swine-in-prrs-stable-and-unstable-herds
#14
Michele Drigo, Enrico Giacomini, Massimiliano Lazzaro, Daniela Pasotto, Dania Bilato, Jessica Ruggeri, Maria Beatrice Boniotti, Giovani Loris Alborali, Massimo Amadori
Porcine Reproductive and Respiratory Syndrome (PRRS) is an elusive model of host/virus relationship in which disease is determined by virus pathogenicity, pig breed susceptibility and phenotype, microbial infectious pressure and environmental conditions. Successful disease control in PRRS-endemic Countries corresponds to "stability", i.e. a condition with no clinical signs of PRRS in the breeding-herd population and no viremia in weaning-age pigs. The aim of this work was to compare the profile and time-course of humoral and cell-mediated immunity in stable and unstable herds, respectively...
June 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29775639/surgical-management-of-lower-urinary-tract-symptoms-attributed-to-benign-prostatic-hyperplasia-aua-guideline
#15
Harris E Foster, Michael J Barry, Philipp Dahm, Manhar C Gandhi, Steven A Kaplan, Tobias S Kohler, Lori B Lerner, Deborah J Lightner, J Kellogg Parsons, Claus G Roehrborn, Charles Welliver, Timothy J Wilt, Kevin T McVary
Purpose; Male lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) is common in men and can have negative effects on quality of life (QOL). It is the hope that this Guideline becomes a reference on the effective evidence-based surgical management of LUTS/BPH. MATERIALS/METHODS: The evidence team searched Ovid MEDLINE, the Cochrane Library, and the Agency for Healthcare Research and Quality (AHRQ) database to identify studies indexed between January 2007 and September 2017...
May 15, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29775484/pseudomonas-aeruginosa-type-iv-minor-pilins-and-pily1-regulate-virulence-by-modulating-fims-algr-activity
#16
Victoria A Marko, Sara L N Kilmury, Lesley T MacNeil, Lori L Burrows
Type IV pili are expressed by a wide range of prokaryotes, including the opportunistic pathogen Pseudomonas aeruginosa. These flexible fibres mediate twitching motility, biofilm maturation, surface adhesion, and virulence. The pilus is composed mainly of major pilin subunits while the low abundance minor pilins FimU-PilVWXE and the putative adhesin PilY1 prime pilus assembly and are proposed to form the pilus tip. The minor pilins and PilY1 are encoded in an operon that is positively regulated by the FimS-AlgR two-component system...
May 18, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29772522/bariatric-surgery-drives-major-rearrangements-of-the-intestinal-microbiota-including-the-biofilm-composition
#17
Giuseppina Campisciano, Carolina Cason, Silvia Palmisano, Michela Giuricin, Alessia Rizzardi, Lory Saveria Croce, Nicolo De Manzini, Manola Comar
The intestinal microbiota disequilibrium has been associated with obesity, while the role of the gut mucosal biofilms in this pathology is still unknown. We analysed the changes in the intestinal microbiota of obese patients after bariatric surgery with the aim of disclosing the rearrangement of the biofilm configuration. Although the bariatric surgery drives major rearrangements of the gut microbiota, obese patients maintain the Prevotella enterotype before and after surgery, as shown by normal weight patients, with an increase of Bacteroides vulgatus and Bacteroides uniformis ...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/29772025/shape-shifting-trypanosomes-flagellar-shortening-followed-by-asymmetric-division-in-trypanosoma-congolense-from-the-tsetse-proventriculus
#18
Lori Peacock, Christopher Kay, Mick Bailey, Wendy Gibson
Trypanosomatids such as Leishmania and Trypanosoma are digenetic, single-celled, parasitic flagellates that undergo complex life cycles involving morphological and metabolic changes to fit them for survival in different environments within their mammalian and insect hosts. According to current consensus, asymmetric division enables trypanosomatids to achieve the major morphological rearrangements associated with transition between developmental stages. Contrary to this view, here we show that the African trypanosome Trypanosoma congolense, an important livestock pathogen, undergoes extensive cell remodelling, involving shortening of the cell body and flagellum, during its transition from free-swimming proventricular forms to attached epimastigotes in vitro...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29771774/bronchoscopic-laser-interstitial-thermal-therapy-an-experimental-study-in-normal-porcine-lung-parenchyma
#19
Roberto F Casal, Garrett Walsh, Mark McArthur, Lori R Hill, Maria F Landaeta, Aristides J Armas Villalba, Philip Ong, Labib Debiane, Erik Vakil, Horiana B Grosu, Carlos A Jimenez, David Ost, Roberto Adachi, George A Eapen
BACKGROUND: Population aging and lung cancer screening strategies may lead to an increase in detection of early-stage lung cancer in medical inoperable patients. Recent advances in peripheral bronchoscopy have made it a suitable platform for ablation of small peripheral tumors. METHODS: We investigated the tissue-ablative effect of a diode laser bronchoscopically applied by a laser delivery fiber (LDF) with wide aperture on porcine lung parenchyma. Laser was tested ex vivo and in vivo to identify the most effective power settings and LDF...
May 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29771539/psi4numpy-an-interactive-quantum-chemistry-programming-environment-for-reference-implementations-and-rapid-development
#20
Daniel G A Smith, Lori A Burns, Dominic A Sirianni, Daniel R Nascimento, Ashutosh Kumar, Andrew M James, Jeffrey B Schriber, Tianyuan Zhang, Boyi Zhang, Adam S Abbott, Eric J Berquist, Marvin H Lechner, Leonardo A Cunha, Alexander G Heide, Jonathan M Waldrop, Tyler Y Takeshita, Asem Alenaizan, Daniel Neuhauser, Rollin A King, Andrew C Simmonett, Justin M Turney, Henry F Schaefer, Francesco A Evangelista, A Eugene DePrince, T Daniel Crawford, Konrad Patkowski, C David Sherrill
Psi4NumPy demonstrates the use of efficient computational kernels from the open-source Psi4 program through the popular NumPy library for linear algebra in Python to facilitate the rapid development of clear, understandable Python computer code for new quantum chemical methods, while maintaining a relatively low execution time. Using these tools, reference implementations have been created for a number of methods, including self-consistent field (SCF), SCF response, many-body perturbation theory, coupled-cluster theory, configuration interaction, and symmetry-adapted perturbation theory...
May 17, 2018: Journal of Chemical Theory and Computation
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