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JOURNAL ARTICLE
Miguel Angel Molina Gutiérrez, María Fernández Camuñas, Jose Antonio Ruíz Domínguez, Marta Bueno Barriocanal, Begoña De Miguel Lavisier, Rosario López López, María de Ceano-Vivas La Calle
OBJECTIVE: Ketamine is a safe and widely used sedative and analgesic in children. The purpose of this study is to evaluate the response to sedoanalgesia for painful procedures in the pediatric emergency department. METHODS: A retrospective study was conducted in children younger than 16 years who underwent painful procedures with intravenous/intranasal ketamine between January 2016 and December 2022. We collected demographic variables, effectiveness, route of administration, indication, dose, sedation strategy, duration of procedure, and associated adverse effects...
May 9, 2024: Pediatric Emergency Care
#2
JOURNAL ARTICLE
Shaoluan Zheng, Jia Feng, Zhiwei Chen, Chuanyuan Wei, Yuyan Pan, Jiaqi Liu
BACKGROUND: The role of high socioeconomic status (SES) as an established risk factor for melanoma has been well documented in Western countries and regions. However, research on the association between melanoma and SES in China remains limited. This study aimed to investigate the association between SES and melanoma incidence and stage in China. METHODS: Five measures of SES were accessed, including education level, ethnic background, per capita household income, occupation, and medical insurance coverage...
May 7, 2024: Annals of Plastic Surgery
#3
JOURNAL ARTICLE
Melissa A Elafros, Alexanndra Brown, Huda Marcus, Thair Dawood, Ghassan I Bachuwa, Mousumi Banerjee, Peter J Winch, Michelle Kvalsund, Eva L Feldman, Lesli E Skolarus, Brian C Callaghan
BACKGROUND AND OBJECTIVES: Distal symmetric polyneuropathy (DSP) is a disabling, often painful condition associated with falls and reduced quality of life. Non-Hispanic Black people and people with low income are underrepresented in existing DSP studies; therefore, it is unknown whether data accurately reflect the prevalence, risk factors, and burden of disease in these populations. METHODS: Patients older than 40 years presenting to an outpatient internal medicine clinic predominantly serving Medicaid patients in Flint, Michigan, were enrolled in a cross-sectional study...
June 2024: Neurology
#4
JOURNAL ARTICLE
Kishor Khanal, Juan A Pastor-Cervantes, Sunay Shah, Jianli Niu, Jonathan Roberts
OBJECTIVES: In the trans-radial era, arm venous access for right heart catheterization (RHC) is rising. Procedural success is affected by many factors, including subclavian/innominate vein stenosis (SVS) and pre-existing wires or catheters. In a study published previously by the same authors, 2% of cases had unsuccessful RHC through the arm, predominantly due to SVS. Since that study, techniques to improve RHC success rates have been developed, including crossing the stenosis with a coronary guidewire, followed by balloon dilatation...
May 7, 2024: Journal of Invasive Cardiology
#5
JOURNAL ARTICLE
Samira Samant, James McCarthy
INTRODUCTION: In presenting this case of tick-borne illness in a patient with known disseminated blastomycosis, we aim to discuss the clinical reasoning and decision-making process when treating a septic presentation in a complex patient with multiple exposures and risk factors, from identifying and addressing the most devastating differentials to selecting appropriate empiric anti-infective regimens. CASE PRESENTATION: We present the case of a 60-year-old male with a medical history of diastolic heart failure, cirrhosis, sarcoidosis, hypertension, splenectomy, and recently diagnosed disseminated blastomycosis, who developed sepsis following a recent tick exposure...
May 2024: WMJ: Official Publication of the State Medical Society of Wisconsin
#6
JOURNAL ARTICLE
Nina Punyamurthy, Kimberly Katz, Alan Vu, Nathan Duncan, Kimberly A Wanat
INTRODUCTION: Blastomycosis is a fungal infection caused by Blastomyces dermatitidis that is hyperendemic in Wisconsin. It commonly presents as a pulmonary infection and frequently disseminates to the skin. Studies evaluating the presentation and diagnosis of blastomycosis with skin as a presenting sign have not been thoroughly evaluated, and understanding the most accurate way to diagnose this infection is important for earlier therapeutic intervention. METHODS: This is a retrospective chart review study of a single institution...
May 2024: WMJ: Official Publication of the State Medical Society of Wisconsin
#7
JOURNAL ARTICLE
Mikaela Camacho, María Isabel Viteri, Paola Yepez, Jorge Estrella Porter, Drifa Belhadi, Caroline Barnes, Jonathan Guillemot
BACKGROUND: Acne is a common disease that is associated with scarring and substantial psychosocial burden. The Global Burden of Skin Disease reported that the burden from acne as measured by disability-adjusted life years (DALYs) from 188 countries and specifically that it is greatest in Western Europe, high-income North America and Southern Latin America. This paper aimed to identify risk factors for acne scarring specific to the Ecuadorian population in order to adapt the 4-ASRAT tool accordingly...
2024: PloS One
#8
JOURNAL ARTICLE
Hashir Aazh, Brian C J Moore, Mercede Erfanian
A confirmatory factor analysis (CFA) of the Tinnitus Impact Questionnaire (TIQ) was performed. In contrast to commonly used tinnitus questionnaires, the TIQ is intended solely to assess the impact of tinnitus by not including items related to hearing loss or tinnitus loudness. This was a psychometric study based on a retrospective cross-sectional analysis of clinical data. Data were available for 155 new patients who had attended a tinnitus and hyperacusis clinic in the UK within a five-month period and had completed the TIQ...
2024: PloS One
#9
JOURNAL ARTICLE
Cécile Rallière, Sabrina Jagot, Nathalie Sabin, Jean-Charles Gabillard
Essential for muscle fiber formation and hypertrophy, muscle stem cells, also called satellite cells, reside beneath the basal lamina of the muscle fiber. Satellite cells have been commonly identified by the expression of the Paired box 7 (Pax7) due to its specificity and the availability of antibodies in tetrapods. In fish, the identification of satellite cells remains difficult due to the lack of specific antibodies in most species. Based on the development of a highly sensitive in situ hybridization (RNAScope®) for pax7, we showed that pax7+ cells were detected in the undifferentiated myogenic epithelium corresponding to the dermomyotome at day 14 post-fertilization in rainbow trout...
2024: PloS One
#10
JOURNAL ARTICLE
Most Shornale Akter, Md Helal Uddin, Sheikh Atikur Rahman, Md Arju Hossain, Md Ashiqur Rahman Ashik, Nurun Nesa Zaman, Omar Faruk, Md Sanwar Hossain, Anzana Parvin, Md Habibur Rahman
Breast cancer (BC) is the most widespread cancer worldwide. Over 2 million new cases of BC were identified in 2020 alone. Despite previous studies, the lack of specific biomarkers and signaling pathways implicated in BC impedes the development of potential therapeutic strategies. We employed several RNAseq datasets to extract differentially expressed genes (DEGs) based on the intersection of all datasets, followed by protein-protein interaction network construction. Using the shared DEGs, we also identified significant gene ontology (GO) and KEGG pathways to understand the signaling pathways involved in BC development...
May 2024: Cancer reports
#11
JOURNAL ARTICLE
Julian Martinez-Mayer, Sebastian Vishnopolska, Catalina Perticarari, Lucia Iglesias Garcia, Martina Hackbartt, Marcela Martinez, Jonathan Zaiat, Andrea Jacome-Alvarado, Debora Braslavsky, Ana Keselman, Ignacio Bergadá, Roxana Marino, Pablo Ramírez, Natalia Pérez Garrido, Marta Ciaccio, Maria Isabel Di Palma, Alicia Belgorosky, Maria Veronica Forclaz, Gabriela Benzrihen, Silvia D'Amato, Maria Lujan Cirigliano, Mirta Miras, Alejandra Paez Nuñez, Laura Castro, Maria Susana Mallea-Gil, Carolina Ballarino, Laura Latorre-Villacorta, Ana Clara Casiello, Claudia Hernandez, Veronica Figueroa, Guillermo Alonso, Analia Morin, Zelmira Guntsche, Hane Lee, Eugene Lee, Yongjun Song, Marcelo Adrian Marti, Maria Ines Perez-Millan
CONTEXT: The pituitary gland is key for childhood growth, puberty, and metabolism. Pituitary dysfunction is associated with a spectrum of phenotypes, from mild to severe. Congenital Hypopituitarism (CH) is the most commonly reported pediatric endocrine dysfunction with an incidence of 1:4000, yet low rates of genetic diagnosis have been reported. OBJECTIVE: We aimed to unveil the genetic etiology of CH in a large cohort of patients from Argentina. METHODS: We performed whole exome sequencing of 137 unrelated cases of CH, the largest cohort examined with this method to date...
May 8, 2024: Journal of Clinical Endocrinology and Metabolism
#12
JOURNAL ARTICLE
Yoon Young Choi, Myeongjee Lee, Eun Hwa Kim, Jae Eun Lee, Inkyung Jung, Jae-Ho Cheong
BACKGROUND: The number of cancer survivors who develop subsequent primary cancers (SPCs) is expected to increase. OBJECTIVE: We evaluated the overall and cancer type-specific risks of SPCs among adult-onset cancer survivors by first primary cancer (FPC) types considering sex and age. METHODS: We conducted a retrospective cohort study using the Health Insurance Review and Assessment database of South Korea including 5-year cancer survivors diagnosed with an FPC in 2009 to 2010 and followed them until December 31, 2019...
May 8, 2024: JMIR Public Health and Surveillance
#13
JOURNAL ARTICLE
Roseclea Chagas Dos Santos, Alessandra Estrela-Lima, Washington Luís Conrado-Dos-Santos, Arianne Oriá, Rafaela de Sousa Gonçalves, Danielle Nascimento Silva, Daniela Farias Larangeira, Maria do Socorro Pires E Cruz, Flaviane Alves de Pinho, Stella Maria Barrouin-Melo
Canine leishmaniasis (CanL) caused by Leishmania infantum commonly progresses with renal and ophthalmic lesions associated with active systemic disease. As chronic inflammation related to immune complex deposits is a pathophysiological factor in the development of both glomerulonephritis and uveitis, we aimed to evaluate renal and ocular histopathological lesions and analyze whether they were related to each other and the clinical degree of the disease. For that, we evaluated 15 dogs from CanL-endemic areas...
May 8, 2024: Veterinary Research Communications
#14
JOURNAL ARTICLE
Yangyang Li, Jiandong Guo, Wendao Liu, Huajin Pang, Yipei Song, Siyi Wu, Fengtao Zhang, Dong Yan, Junwei Chen, Chao An, Chengzhi Li
BACKGROUND: Portal vein tumor thrombosis (PVTT) signifies late-stage hepatocellular carcinoma (HCC) with high-risk progression and poor prognosis. As a standard treatment, sorafenib monotherapy has limited the efficacy in managing HCC with PVTT. Currently, both hepatic arterial infusion chemotherapy (HAIC) and the combination of camrelizumab and rivoceranib have shown favorable survival benefits for advanced HCC, surpassing the standard sorafenib treatment. In this study, we investigate the safety and efficacy of HAIC combined with camrelizumab and rivoceranib in treating HCC patients with PVTT...
May 8, 2024: Hepatology International
#15
JOURNAL ARTICLE
Yongsheng Liu, Man Jiang, Meitian Zhang, Yawen Xie, Lixin Wang, Pilong Shi, Qianlong Zhang, Qianhui Zhang, Kai Liu, Jiajun Zhou, Chao Song, Hongli Sun
BACKGROUND: Cardiac hypertrophy is the common pathological process of multiple cardiovascular diseases. However, the molecular mechanisms of cardiac hypertrophy are unclear. Long non-coding RNA (lncRNA), a newly discovered type of transcript that has been demonstrated to function as crucial regulators in the development of cardiovascular diseases. This study revealed a novel regulatory pathway of lncRNA in cardiac hypertrophy. METHODS: The cardiac hypertrophy models were established by transverse aortic constriction (TAC) in mice and angiotensin II (Ang II) in HL-1 cardiomyocytes...
May 8, 2024: Cardiovascular Drugs and Therapy
#16
JOURNAL ARTICLE
Qiao Zeng, Xueqian Xia, Li Jiang, Jin Chen, Yuhang Liu, Yue Hu
OBJECTIVE: To determine the efficacy and safety of perampanel (PER) as an adjunctive therapy in children aged 4-12 years with epilepsy. METHODS: We performed a non-randomized, open-label, placebo-uncontrolled, real-world self-controlled study that included 216 young children (aged 4-12 years) with epilepsy who received PER as adjunctive therapy at the children's hospital affiliated with Chongqing Medical University from July 4, 2020, to September 20, 2023...
May 8, 2024: Journal of Neurology
#17
REVIEW
P Marcolin, B Oliveira Trindade, S Bueno Motter, G R Brandão, N Messer, S Mazzola Poli de Figueiredo
PURPOSE: While the detrimental effects of smoking on postoperative outcomes are recognized, the extent of its risk for inguinal hernia repair remains unclear. Our study aims to assess the influence of smoking on patients who undergo inguinal hernia repair. METHODS: We systematically reviewed PubMed, Embase, and Cochrane databases. Our goal was to identify studies that compared postoperative outcomes in smoking and non-smoking patients after inguinal hernia repair, and which employed a multivariate analysis to reduce possible confounding factors...
May 8, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
#18
JOURNAL ARTICLE
Naoki Fujita, Masaki Momota, Osamu Soma, Daisuke Noro, Jotaro Mikami, Yuki Miura, Hiroyuki Ito, Takahiro Yoneyama, Yasuhiro Hashimoto, Kazuaki Yoshikawa, Chikara Ohyama, Shingo Hatakeyama
PURPOSE: To evaluate the impact of severe acute kidney injury (AKI) on short-term mortality in patients with urosepsis. METHODS: This prospective cohort study evaluated 207 patients with urosepsis. AKI was diagnosed in accordance with the Kidney Disease Improving Global Outcomes criteria, and severe AKI was defined as stage 2 or 3 AKI. Patients were divided into two groups: patients who developed severe AKI (severe AKI group) and patients who did not (control group)...
May 8, 2024: World Journal of Urology
#19
JOURNAL ARTICLE
Nicole Anais Milanko, Michael Eamon Kelly, Greg Turner, Joeseph Kong, Cori Behrenbruch, Helen Mohan, Glen Guerra, Satish Warrier, Jacob McCormick, Alexander Heriot
UNLABELLED: Pelvic exenteration (PE) is a technically challenging surgical procedure. More recently, quality of life and survivorship following PEs are being increasingly acknowledged as important patient outcomes. This includes evaluating major long-term complications such as hernias, defined as the protrusion of internal organs through a facial defect (The PelvEx Collaborative in Br J Surg 109:1251-1263, 2022), for which there is currently limited literature. The aim of this paper is to ascertain the incidence and risk factors for postoperative hernia formation among our PE cohort managed at a quaternary centre...
May 8, 2024: International Journal of Colorectal Disease
#20
JOURNAL ARTICLE
Mao Mao, Yien-Ming Kuo, Alfred K Yu, Cassandre Labelle-Dumais, Yvonne Ou, Douglas B Gould
PURPOSE: Mutations in the genes encoding type IV collagen alpha 1 (COL4A1) and alpha 2 (COL4A2) cause a multisystem disorder that includes ocular anterior segment dysgenesis (ASD) and glaucoma. We previously showed that transforming growth factor beta (TGFβ) signaling was elevated in developing anterior segments from Col4a1 mutant mice and that reducing TGFβ signaling ameliorated ASD, supporting a role for the TGFβ pathway in disease pathogenesis. Here, we tested whether altered TGFβ signaling also contributes to glaucoma-related phenotypes in Col4a1 mutant mice...
May 1, 2024: Investigative Ophthalmology & Visual Science
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