Kevin J Cummings, James C Leiter, Felicia L Trachtenberg, Benjamin W Okaty, Robert A Darnall, Elisabeth A Haas, Ronald M Harper, Eugene E Nattie, Henry F Krous, Othon J Mena, George B Richerson, Susan M Dymecki, Hannah C Kinney, Robin L Haynes
The failure of chemoreflexes, arousal, and/or autoresuscitation to asphyxia may underlie some sudden infant death syndrome (SIDS) cases. In Part I, we showed that some SIDS infants had altered 5-hydroxytryptamine (5-HT)2A/C receptor binding in medullary nuclei supporting chemoreflexes, arousal, and autoresuscitation. Here, using the same dataset, we tested the hypotheses that the prevalence of low 5-HT1A and/or 5-HT2A/C receptor binding (defined as levels below the 95% confidence interval of controls-a new approach), and the percentages of nuclei affected are greater in SIDS versus controls, and that the distribution of low binding varied with age of death...
February 21, 2024: Journal of Neuropathology and Experimental Neurology