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Sudden infant death syndrome

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https://www.readbyqxmd.com/read/29331839/functional-characterization-of-a-novel-herg-variant-in-a-family-with-recurrent-sudden-infant-death-syndrome-retracting-a-genetic-diagnosis
#1
Valentine Sergeev, Frances Perry, Thomas M Roston, Shubhayan Sanatani, Glen F Tibbits, Thomas W Claydon
Long QT syndrome (LQTS) is the most common cardiac ion channelopathy and has been found to be responsible for approximately 10% of sudden infant death syndrome (SIDS) cases. Despite increasing use of broad panels and now whole exome sequencing (WES) in the investigation of SIDS, the probability of identifying a pathogenic mutation in a SIDS victim is low. We report a family-based study who are afflicted by recurrent SIDS in which several members harbor a variant, p.Pro963Thr, in the C-terminal region of the human-ether-a-go-go (hERG) gene, published to be responsible for cases of LQTS type 2...
December 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29329929/detoxification-genes-polymorphisms-in-sids-exposed-to-tobacco-smoke
#2
Laura Filonzi, Cinzia Magnani, Anna Maria Lavezzi, Marina Vaghi, Luana Nosetti, Francesco Nonnis Marzano
The best hypothesis to explain Sudden Infant Death Syndrome (SIDS) pathogenesis is offered by the "triple risk model", which suggests that an interaction of different variables related to exogenous stressors and infant vulnerability may lead to the syndrome. Environmental factors are triggers that act during a particular sensible period, modulated by intrinsic genetic characteristics. Although literature data show that one of the major SIDS risk factors is smoking exposure, a specific involvement of molecular components has never been highlighted...
January 9, 2018: Gene
https://www.readbyqxmd.com/read/29324729/vital-signs-trends-and-disparities-in-infant-safe-sleep-practices-united-states-2009-2015
#3
Jennifer M Bombard, Katherine Kortsmit, Lee Warner, Carrie K Shapiro-Mendoza, Shanna Cox, Charlan D Kroelinger, Sharyn E Parks, Deborah L Dee, Denise V D'Angelo, Ruben A Smith, Kim Burley, Brian Morrow, Christine K Olson, Holly B Shulman, Leslie Harrison, Carri Cottengim, Wanda D Barfield
There have been dramatic improvements in reducing infant sleep-related deaths since the 1990s, when recommendations were introduced to place infants on their backs for sleep. However, there are still approximately 3,500 sleep-related deaths among infants each year in the United States, including those from sudden infant death syndrome, accidental suffocation and strangulation in bed, and unknown causes. Unsafe sleep practices, including placing infants in a nonsupine (on side or on stomach) sleep position, bed sharing, and using soft bedding in the sleep environment (e...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29299712/cardiovascular-autonomic-dysfunction-in-sudden-infant-death-syndrome
#4
REVIEW
Rosemary S C Horne
A failure of cardiorespiratory control mechanisms, together with an impaired arousal response from sleep, are believed to play an important role in the final event of sudden infant death syndrome (SIDS). The 'triple risk model' describes SIDS as an event that results from the intersection of three overlapping factors: (1) a vulnerable infant, (2) a critical developmental period in homeostatic control and (3) an exogenous stressor. In an attempt to understand how the triple risk hypothesis is related to infant cardiorespiratory physiology, many researchers have examined how the known risk and protective factors for SIDS alter infant cardiovascular control during sleep...
January 3, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29289380/sudden-infant-death-syndrome-attention-deficit-hyperactivity-disorder-and-vaccines-longitudinal-population-analyses
#5
Y Tony Yang, Jana Shaw
Concerns about a potential link between sudden infant death syndrome (SIDS), attention deficit and hyperactivity disorder (ADHD) and vaccination are unsupported by longitudinal evidence. The analyses employed a multivariate mixed-effects model analyzing data from the National Immunization Survey, School Vaccination Assessment Reports, National Vital Statistics and National Children's Health Survey. We found that state-level childhood vaccine uptake for age appropriate vaccines was neither associated with the decline in the incidence of SIDS nor rise in the prevalence of ADHD...
December 27, 2017: Vaccine
https://www.readbyqxmd.com/read/29249897/is-it-time-for-a-sudden-infant-death-syndrome-sids-awareness-campaign-community-stakeholders-perceptions-of-sids
#6
Audra Gollenberg, Kim Fendley
Background: Sudden infant death syndrome (SIDS) remains a leading cause of infant death in the United States and in Virginia, the SIDS rate is higher than the national average. We sought to gauge the perceptions among community-identified stakeholders as to community resource needs to reduce SIDS. Methods: We used snowball sampling to identify important community stakeholders to be interviewed as key informants. A semi-structured interview lasting 45 min-2 hours was delivered to determine resource needs to reduce SIDS, and whether high-risk community members were aware of SIDS risk factors among stakeholders representing a variety of disciplines...
2018: Child care in practice: Northern Ireland journal of multi-disciplinary child care practice
https://www.readbyqxmd.com/read/29243157/why-is-a-prone-sleeping-position-dangerous-for-certain-infants
#7
Roger W Byard, Fiona Bright, Robert Vink
The prone (face down) sleeping position is known to be associated with a significantly increased risk of sudden and unexpected death in infancy (sudden infant death syndrome or SIDS), however, the reasons for this are unclear. Suggested mechanisms have involved suffocation from occlusion of the external airways by soft bedding/pillows or from flattening of the nose with backward displacement of the tongue, rebreathing of carbon dioxide, blunting of arousal responses with decreased cardiac responses to auditory stimulation, diaphragmatic splinting or fatigue, lowering of vasomotor tone with tachycardia, nasopharyngeal bacterial overgrowth, overheating, alteration of sleep patterns, compromise of cerebral blood flow and upper airway obstruction from distortion of nasal cartilages...
December 14, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29241647/safety-of-currently-licensed-hepatitis-b-surface-antigen-vaccines-in-the-united-states-vaccine-adverse-event-reporting-system-vaers-2005-2015
#8
Penina Haber, Pedro L Moro, Carmen Ng, Paige W Lewis, Beth Hibbs, Sarah F Schillie, Noele P Nelson, Rongxia Li, Brock Stewart, Maria V Cano
INTRODUCTION: Currently four recombinant hepatitis B (HepB) vaccines are in use in the United States. HepB vaccines are recommended for infants, children and adults. We assessed adverse events (AEs) following HepB vaccines reported to the Vaccine Adverse Event Reporting System (VAERS), a national spontaneous reporting system. METHODS: We searched VAERS for reports of AEs following single antigen HepB vaccine and HepB-containing vaccines (either given alone or with other vaccines), from January 2005 - December 2015...
December 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29235984/deaths-leading-causes-for-2015
#9
Melonie Heron
Objectives-This report presents final 2015 data on the 10 leading causes of death in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal death are also presented. This report supplements "Deaths: Final Data for 2015," the National Center for Health Statistics' annual report of final mortality statistics. Methods-Data in this report are based on information from all death certificates filed in the 50 states and the District of Columbia in 2015. Causes of death classified by the International Classification of Diseases, Tenth Revision (ICD-10) are ranked according to the number of deaths assigned to rankable causes...
November 2017: National Vital Statistics Reports
https://www.readbyqxmd.com/read/29221913/facial-asymmetry-correction-with-moulded-helmet-therapy-in-infants-with-deformational-skull-base-plagiocephaly
#10
Matthias Kreutz, Brigitte Fitze, Christoph Blecher, Augello Marcello, Ruben Simon, Rebecca Cremer, Hans-Florian Zeilhofer, Christoph Kunz, Johannes Mayr
PURPOSE: The recommendation issued by the American Academy of Pediatrics in the early 1990s to position infants on their back during sleep to prevent sudden infant death syndrome (SIDS) has dramatically reduced the number of deaths due to SIDS but has also markedly increased the prevalence of positional skull deformation in infants. Deformation of the base of the skull occurs predominantly in very severe deformational plagiocephaly and is accompanied by facial asymmetry, as well as an altered ear position, called ear shift...
October 16, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29208338/risky-behaviors-of-mothers-with-infants-on-sudden-infant-death-syndrome-in-turkey
#11
Çiğdem Erdoğan, Türkan Turan
PURPOSE: Sudden infant death syndrome is the most common cause of death during the post-neonatal period. Factors such as sleeping position, bed sharing, pillow use, smoking during pregnancy and the breastfeeding period constitute risk factors for sudden infant death syndrome. This study aims to identify the risky behaviors of mothers with infants that may put their children at risk for sudden infant death syndrome. DESIGN AND METHODS: This is a cross-sectional, descriptive study...
December 2, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29206359/parent-infant-co-sleeping-and-the-implications-for-sudden-infant-death-syndrome
#12
Joanne Straw, Pat Jones
In 2015 the National Institute for Health and Care Excellence (NICE) updated its 2006 guideline to clarify the association between parent infant co-sleeping and sudden infant death syndrome (SIDS). The practice of co-sleeping is a topic of continuing controversy and debate. Rather than highlighting the risks, the emphasis of the NICE guideline is to provide parents with balanced information so that they can make informed decisions about where their babies sleep. This contradicts previous public health messages on co-sleeping that discourages parents from the practice...
December 5, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/29189142/interpretation-of-cannabis-findings-in-the-hair-of-very-young-children-mission-impossible
#13
Pascal Kintz, Alice Ameline, Aude Eibel, Annie Geraut, Audrey Farrugia, Laurent Berthelon, Jean-Sebastien Raul
BACKGROUND: Hair has been suggested since the middle of the 90's to be a suitable matrix to document repetitive exposure to cannabis. Because it is possible to detect ∆9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) in cannabis smoke, the identification of the metabolite, 11-nor-∆9-tetrahydrocannabinol carboxylic acid (THC-COOH) has been considered to allow the discrimination of active use. OBJECTIVE: Whereas the detection of drugs in a child's hair unambiguously shows drug handling in the environment of the child, it is difficult to distinguish between systemic incorporation into hair after ingestion or inhalation and external deposition into hair from smoke, dust, or contaminated surfaces...
November 29, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29184885/sudden-infant-death-syndrome-infection-prone-sleep-position-and-vagal-neuroimmunology
#14
Paul Nathan Goldwater
Recent findings suggest that infection (and sepsis) stand alone as the only plausible mechanism of causation of sudden infant death syndrome (SIDS) and accordingly achieves congruence with all clinicopathological and epidemiological findings. This review examines the role of infection in the pathogenesis of SIDS in the context of the major risk factor of prone sleep position. The study explores how sleep position could interact with the immune system and inflammatory response via vagal neural connections, which could play key roles in gut and immune homeostasis...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29181379/molecular-autopsy-for-sudden-death-in-the-young-is-data-aggregation-the-key
#15
Manuel Rueda, Jennifer L Wagner, Tierney C Phillips, Sarah E Topol, Evan D Muse, Jonathan R Lucas, Glenn N Wagner, Eric J Topol, Ali Torkamani
The Scripps molecular autopsy study seeks to incorporate genetic testing into the postmortem examination of cases of sudden death in the young (<45 years old). Here, we describe the results from the first 2 years of the study, which consisted of whole exome sequencing (WES) of a cohort of 50 cases predominantly from San Diego County. Apart from the individual description of cases, we analyzed the data at the cohort-level, which brought new perspectives on the genetic causes of sudden death. We investigated the advantages and disadvantages of using WES compared to a gene panel for cardiac disease (usually the first genetic test used by medical examiners)...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29173325/intestinal-microbiota-composition-in-sudden-infant-death-syndrome-and-age-matched-controls
#16
Lex E X Leong, Steven L Taylor, Aravind Shivasami, Paul N Goldwater, Geraint B Rogers
OBJECTIVE: To assess whether features of the infant intestinal microbiome, including the carriage of toxigenic bacteria, are associated with sudden infant death syndrome (SIDS). STUDY DESIGN: We undertook a case-controlled analysis of fecal microbiology in SIDS. Fecal material was obtained from 44 cases and 44 aged-matched controls. Microbiota composition was determined by 16S ribosomal RNA gene amplicon sequencing and comparisons between cases and controls made based on both bacterial alpha diversity measures and unconstrained ordination...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29166377/the-effect-of-body-position-on-esophageal-reflexes-in-cats-a-possible-mechanism-of-sids
#17
Ivan M Lang, Bidyut K Medda, Reza Shaker, Sudarshan Jadcherla
BACKGROUND: It has been hypothesized that life threatening events are caused by supra-esophageal reflux (SER) of gastric contents which activates laryngeal chemoreflex-stimulated apnea. Placing infants supine decreases the risk of sudden infant death syndrome (SIDS). The aim of this study was to determine whether body position affects esophageal reflexes that control SER. METHODS: We instrumented the pharyngeal and esophageal muscles of decerebrate cats (N=14) to record EMG or manometry, and investigated the effects of body position on the esophago-upper esophageal sphincter (UES) contractile reflex (EUCR), esophago-UES relaxation reflex (EURR), esophagus-stimulated pharyngeal swallow response (EPSR), secondary peristalsis (SP), and pharyngeal swallow (PS)...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166367/smoke-free-policies-in-the-world-s-50-busiest-airports-august-2017
#18
Michael A Tynan, Elizabeth Reimels, Jennifer Tucker, Brian A King
Exposure to secondhand smoke from burning tobacco products causes premature death and disease, including coronary heart disease, stroke, and lung cancer among nonsmoking adults and sudden infant death syndrome, acute respiratory infections, middle ear disease, exacerbated asthma, respiratory symptoms, and decreased lung function in children (1,2). The U.S. Surgeon General has concluded that there is no risk-free level of exposure to secondhand smoke (1). Previous CDC reports on airport smoke-free policies found that most large-hub airports in the United States prohibit smoking (3); however, the extent of smoke-free policies at airports globally has not been assessed...
November 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29147916/integrative-analysis-of-proteomics-data-to-obtain-clinically-relevant-markers
#19
Nathan Salomonis
The analysis of proteomics data can be significantly challenging. Beyond the technical challenges of accurately identifying and quantifying peptides, identifying the most biologically coherent set of biomarkers can be a particularly daunting step. In this chapter, we will review a series of methods implemented in the software AltAnalyze that can be used to normalize proteomics peptide counts, identify a minimal set of the most distinguishing morbidity-associated biomarkers, and connect up these results to known pathways and interacting protein and regulatory networks...
November 18, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29140536/birth-outcomes-among-first-nations-inuit-and-m%C3%A3-tis-populations
#20
Amanda J Sheppard, Gabriel D Shapiro, Tracey Bushnik, Russell Wilkins, Serenity Perry, Jay S Kaufman, Michael S Kramer, Seungmi Yang
BACKGROUND: First Nations, Inuit, and Métis are at higher risk of adverse birth outcomes than are non-Indigenous people. However, relatively little perinatal information is available at the national level for Indigenous people overall or for specific identity groups. DATA AND METHODS: This analysis describes and compares rates of preterm birth, small-for-gestational-age birth, large-for-gestational-age birth, stillbirth, and infant mortality (neonatal, postneonatal, and cause-specific) in a nationally representative sample of First Nations, Inuit, Métis, and non-Indigenous births...
November 15, 2017: Health Reports
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