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Crohn disease

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https://www.readbyqxmd.com/read/29244192/daily-hassles-score-associates-with-the-somatic-and-psychological-health-of-patients-with-crohn-s-disease
#1
Orly Sarid, Vered Slonim-Nevo, Ruslan Sergienko, Avihu Pereg, Elena Chernin, Terri Singer, Dan Greenberg, Doron Schwartz, Hillel Vardi, Michael Friger, Shmuel Odes
OBJECTIVE: To examine the associations of daily hassles with the somatic and psychological health of Crohn's disease (CD) patients. METHOD: A cross-sectional study of 400 self-selected adult CD patients was performed with completion of demographic, medical, and psychosocial questionnaires: economic status; Patient Harvey-Bradshaw Index of disease activity; Daily Hassles Scale (DHS); Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and Short-Form Health Survey (SF-36 Physical and Mental Health) quality of life measures; Brief Symptom Inventory of psychological stress with summary Global Severity Index (GSI); Family Assessment Device; and List of Threatening Life Experiences...
December 15, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29243105/comparative-effectiveness-of-infliximab-versus-adalimumab-in-patients-with-biologic-na%C3%A3-ve-crohn-s-disease
#2
Amine Benmassaoud, Talal Al-Taweel, Mark Solomon Sasson, Dasha Moza, Matthew Strohl, Uri Kopylov, Laurence Paradis-Surprenant, Mohanad Almaimani, Alain Bitton, Waqqas Afif, Peter L Lakatos, Talat Bessissow
BACKGROUND: Direct head-to-head studies comparing the long-term outcomes of infliximab (IFX) to adalimumab (ADA) in Crohn's disease (CD) are sparse. AIMS: We compared the short-term and long-term efficacy and safety of IFX and ADA in CD. METHODS: We performed a single-center retrospective study including biologic-naïve adult patients with CD who were started on IFX or ADA at the McGill University Health Center. The primary end points were clinical response and remission at 12 months...
December 14, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29241167/nutritional-screening-and-clinical-outcome-in-hospitalized-patients-with-crohn-s-disease
#3
Azusa Takaoka, Masaya Sasaki, Naoko Nakanishi, Mika Kurihara, Akiko Ohi, Shigeki Bamba, Akira Andoh
BACKGROUND/AIMS: Hospitalized patients with Crohn's disease (CD) can develop severe nutritional deficits. However, the nutritional screening tools with the most utility for such patients are still unknown. METHODS: Nutritional status of 40 CD patients was assessed on admission using several screening tools and laboratory tests. Their validity was evaluated in relation to length of hospital stay (LOS) and intestinal resection. Receiver operating characteristic analysis was performed to predict prolonged LOS (≥28 days)...
December 14, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29241039/route-connection-mouth-to-intestine-in-colitis
#4
Naohiro Inohara
In a recent study published in Science, Atarashi et al. (2017) showed that Klebsiella strains isolated from the saliva of Crohn's disease patients can induce Th1 cell responses to promote colitis. Their findings highlight the importance of the oral cavity as a potential reservoir for bacteria that can promote intestinal disease.
December 13, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29240877/prepouch-ileitis-after-ileal-pouch-anal-anastomosis-patterns-of-presentation-and-risk-factors-for-failure-of-treatment
#5
Matteo Rottoli, Carlo Vallicelli, Eleonora Bigonzi, Paolo Gionchetti, Fernando Rizzello, Massimo P Di Simone, Gilberto Poggioli
Background and Aims: There is a lack in the literature about prepouch ileitis [PI], in particular regarding risk factors associated with failure of the medical treatment. Aim of the study is to analyse the characteristics of PI patients and to compare those who required surgery with those who were successfully treated with conservative therapy. Methods: All cases presenting a diagnosis of PI were included and analysed. Patients eventually requiring surgery were compared with those who were managed conservatively, for symptoms of presentation, endoscopic characteristics, and rate of response to medical treatment...
October 9, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29240002/practices-attitudes-and-knowledge-about-crohn-s-disease-and-smoking-cessation-among-gastroenterologists
#6
Benjamin Nulsen, Bruce E Sands, Brijen J Shah, Ryan C Ungaro
OBJECTIVE: Cigarette smoking is one of the most important, modifiable environmental factors in Crohn's disease (CD) and screening for tobacco use is an official recommendation and quality measure in the care of CD patients. The objective of this study was to learn more about gastroenterologists' practices, opinions, and knowledge in this area. PATIENTS AND METHODS: A 15 question survey was sent through email to two national gastroenterology distribution lists. Questions were written in multiple choice formats and were designed to collect information about gastroenterologists' practices, attitudes, and knowledge regarding smoking cessation in CD patients...
December 12, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29239001/comparison-of-infliximab-with-adalimumab-in-827-biologic-na%C3%A3-ve-patients-with-crohn-s-disease-a-population-based-danish-cohort-study
#7
S Singh, N N Andersen, M Andersson, E V Loftus, T Jess
BACKGROUND: There are conflicting data on comparative effectiveness of adalimumab and infliximab in patients with Crohn's disease (CD). AIMS: To compare the effectiveness and safety of adalimumab and infliximab in biologic-naïve patients with CD, in a nationwide register-based propensity score-matched cohort study in Denmark. METHODS: A total of 2908 Danish adults with CD had been treated with adalimumab or infliximab as their first biologic agent between 2005-2014...
December 14, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29236792/specificities-of-presentation-of-crohn-s-disease-in-childhood
#8
Bruna Karoline Pinheiro França Protásio, Camila Maria Pinheiro Machado Martins Barbosa, Clarice Blaj Neufeld, Leandro Dimasi Buck, Lygia de Souza Lima Laund, Mauro Sergio Toporovski, Thais Cristina Visoni
The incidence of inflammatory bowel disease in the pediatric population has increased in the last years. The most common form of inflammatory bowel disease is Crohn's disease and, according to its form and age of presentation, it is possible to predict the evolution of the disease.
December 7, 2017: Einstein
https://www.readbyqxmd.com/read/29235392/re-evaluating-osteoporosis-and-fracture-risk-in-crohn-s-disease-patients-in-the-era-of-tnf-alpha-inhibitors
#9
Shahrad Hakimian, Joan Kheder, Seth Arum, David R Cave, Benjamin Hyatt
INTRODUCTION: Patients with Crohn's disease (CD) are at increased risk for osteoporosis and fractures as compared to the general population. Recently, various cytokines including tumor necrosis factor (TNF)-alpha are found to play a major role in bone health. In this study, we aimed to gain a better understanding of the risk factors for osteoporosis and vitamin D deficiency in the era of TNF-alpha inhibitors. METHODS: We conducted a retrospective review of 464 consecutive patients with CD in our GI clinic between 2008 and 2015...
December 13, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29232213/postoperative-mortality-after-nonelective-surgery-for-inflammatory-bowel-disease-patients-in-the-era-of-biologics
#10
Carla F Justiniano, Christopher T Aquina, Adan Z Becerra, Zhaomin Xu, Courtney I Boodry, Alex A Swanger, John R T Monson, Fergal J Fleming
OBJECTIVE: The aim of the study was to analyze recent trends in the rate of nonelective surgery and corresponding mortality for inflammatory bowel disease (IBD) patients since the rise of biologic use. BACKGROUND: Modern biologic therapy has improved outcomes for IBD, but little is known about the impact on mortality rates after nonelective surgery. METHODS: New York's Statewide Planning & Research Cooperative System was queried for hospital admissions for ulcerative colitis (UC) with concurrent colectomy and Crohn disease (CD) with concurrent small bowel resection or colectomy from 2000 to 2013...
December 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29230300/preoperative-hypoalbuminemia-is-associated-with-an-increased-risk-for-intra-abdominal-septic-complications-after-primary-anastomosis-for-crohn-s-disease
#11
Xuanhui Liu, Xianrui Wu, Chi Zhou, Tuo Hu, Jia Ke, Yufeng Chen, Xiaosheng He, Xiaobin Zheng, Xiaowen He, Jiancong Hu, Min Zhi, Xiang Gao, Pinjin Hu, Xiaojian Wu, Ping Lan
Objective: The aim of this study was to evaluate the impact of preoperative hypoalbuminemia on the development of intra-abdominal septic complications (IASCs) after primary anastomosis for patients with Crohn's disease (CD). Methods: All CD patients undergoing bowel resection with a primary anastomosis during the study period from 2007 to 2015 were enrolled. The association of preoperative hypoalbuminemia (<30 g/L) with the risk for IASCs were assessed using both univariate and multivariate analyses...
November 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/29230144/risk-stratification-for-prevention-of-recurrence-of-postoperative-crohn-s-disease
#12
Shirley Cohen-Mekelburg, Yecheskel Schneider, Stephanie Gold, Ellen Scherl, Adam Steinlauf
Although there have been significant advances in medical therapies to treat Crohn's disease, an estimated 50% of patients will require surgery within the first decade of disease duration. Of these patients, a substantial number will develop recurrent symptoms within the first postoperative year. To prevent disease recurrence, many physicians use postoperative prophylactic therapy. Randomized, controlled trials, although limited in number, have demonstrated that a prophylactic postoperative strategy is effective at reducing recurrence (both clinical and endoscopic) in high-risk patients...
November 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29230143/postoperative-recurrence-of-crohn-s-disease
#13
Gary R Lichtenstein
No abstract text is available yet for this article.
November 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29228844/the-adherence-to-the-therapy-in-inflammatory-bowel-disease-beyond-the-number-of-the-tablets
#14
Davide Giuseppe Ribaldone, Marta Vernero, Giorgio Maria Saracco, Rinaldo Pellicano, Fabio Finocchiaro, Gian Paolo Caviglia, Marco Astegiano
OBJECTIVES: The therapy of the inflammatory bowel diseases is quite complex. A partial compliance increases the relapse probability and the health expenditure. The aim of the study is to correctly study the adherence to the therapy in a single centre eliminating the bias of a different relationship of trust with different doctors. MATERIALS AND METHODS: We conducted a blind prospective study on the adherence evaluated for mesalazine. RESULTS: Three hundred and seventy-six patients were included in the final analysis...
December 11, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29228739/regulatory-role-of-nkg2d-nk-cells-in-intestinal-lamina-propria-by-secreting-double-edged-th1-cytokines-in-ulcerative-colitis
#15
Fan Wang, Pai-Lan Peng, Xue Lin, Ying Chang, Jing Liu, Rui Zhou, Jia-Yan Nie, Wei-Guo Dong, Qiu Zhao, Jin Li
The role of intestinal lamina propria (LP) NKG2D+ NK cells is unclear in regulating Th1/Th2 balance in ulcerative colitis (UC). In this study, we investigated the frequency of LP NKG2D+ NK cells in DSS-induced colitis model and intestinal mucosal samples of UC patients, as well as the secretion of Th1/Th2/Th17 cytokines in NK cell lines after MICA stimulation. The role of Th1 cytokines in UC was validated by bioinformatics analysis. We found that DSS-induced colitis in mice was characterized by a Th2-mediated process...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228712/the-cargo-protein-map17-pdzk1ip1-regulates-the-immune-microenvironment
#16
José M García-Heredia, Amancio Carnero
Inflammation is a complex defensive response activated after various harmful stimuli allowing the clearance of damaged cells and initiating healing and regenerative processes. Chronic, or pathological, inflammation is also one of the causes of neoplastic transformation and cancer development. MAP17 is a cargo protein that transports membrane proteins from the endoplasmic reticulum. Therefore, its overexpression may be linked to an excess of membrane proteins that may be recognized as an unwanted signal, triggering local inflammation...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226412/editorial-anti-tnf-therapy-and-myopenia-in-crohn-s-disease-another-step-towards-personalised-medicine
#17
EDITORIAL
C D Murray
No abstract text is available yet for this article.
January 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29226405/editorial-anti-tnf-therapy-and-myopenia-in-crohn-s-disease-another-step-towards-personalised-medicine-authors-reply
#18
EDITORIAL
N S Ding, G Malietzis, A L Hart
No abstract text is available yet for this article.
January 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29226370/anti-infliximab-antibody-concentrations-can-guide-on-treatment-intensification-in-patients-with-crohn-s-disease-who-lose-clinical-response
#19
E Dreesen, T Van Stappen, V Ballet, M Peeters, G Compernolle, S Tops, K Van Steen, G Van Assche, M Ferrante, S Vermeire, A Gils
BACKGROUND: The presence of antibodies towards infliximab (ATI) is associated with lower infliximab (IFX) trough concentrations and loss of response. IFX treatment intensification is effective for restoring response in most, but not all patients with Crohn's disease (CD). AIM: To compare outcome, pharmacokinetics and immunogenicity of treatment intensification strategies in patients with CD who lost clinical response to IFX. METHODS: A retrospective cohort study was conducted, including 103 patients with CD who lost clinical response during IFX maintenance therapy and therefore received a double dose IFX (10 mg/kg) and/or a next infusion after a shortened interval...
December 11, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29226154/reduced-transferrin-levels-in-active-inflammatory-bowel-disease
#20
Malgorzata Matusiewicz, Katarzyna Neubauer, Paulina Lewandowska, Andrzej Gamian, Malgorzata Krzystek-Korpacka
Inflammatory bowel disease (IBD) is an inflammatory disease of unclear etiopathogenesis and challenging diagnosis, frequently complicated by anemia and malnutrition. C-reactive protein (CRP) remains the only biochemical marker of clinical relevance. The aim of this study was to test hypothesis that transferrin, coinfluenced by inflammation, malnutrition, anemia, and oxidative stress, may better reflect global IBD patient's condition than any other more specific index. Transferrin and other indices of inflammation, anemia, malnutrition, and oxidative stress were measured in 137 IBD patients (Crohn's disease (CD): n = 63 and ulcerative colitis (UC): n = 74) and 97 controls...
2017: BioMed Research International
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