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https://www.readbyqxmd.com/read/28432093/diversity-of-integrative-and-conjugative-elements-of-streptococcus-salivarius-and-their-intra-and-interspecies-transfer
#1
Narimane Dahmane, Virginie Libante, Florence Charron-Bourgoin, Eric Guédon, Gérard Guédon, Nathalie Leblond-Bourget, Sophie Payot
Integrative and Conjugative Elements (ICEs) are widespread chromosomal mobile genetic elements, which can transfer autonomously by conjugation in bacteria. Thirteen ICEs with a conjugation module closely related to that of ICESt3 of Streptococcus thermophilus were characterized in Streptococcus salivarius by whole genome sequencing. Sequence comparison highlighted ICE evolution by shuffling of 3 different integration/excision modules (for integration in the 3' end of fda, rpsI or rpmG genes) with the conjugation module of the ICESt3 subfamily...
April 21, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28422156/anticancer-properties-of-a-defensin-like-class-iid-bacteriocin-laterosporulin10
#2
Piyush Baindara, Ankur Gautam, G P S Raghava, Suresh Korpole
Laterosporulin10 (LS10) is a defensin like peptide from Brevibacillus sp. strain SKDU10 that inhibited microbial pathogens. However, in this study, anticancer activity of LS10 was examined against different cancer cell lines and compared with normal cells. LS10 displayed cytotoxicity against cancer cells like MCF-7, HEK293T, HT1080, HeLa and H1299 at below 10 μM concentration, but not against prostate epithelium cells RWPE-1. Additionally, no hemolysis was observed at significantly higher concentration compared to IC50 values observed for different cancer cell lines...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28401466/antibacterial-effects-of-lactobacillus-isolates-of-curd-and-human-milk-origin-against-food-borne-and-human-pathogens
#3
Chetan Sharma, Brij Pal Singh, Nishchal Thakur, Sachin Gulati, Sanjolly Gupta, Santosh Kumar Mishra, Harsh Panwar
This study was undertaken to assess the antibacterial efficacy of lactobacilli isolated from curd and human milk samples. Identities of thirty-one different lactobacilli (20 from curd and 11 from human milk) were confirmed by genus-specific PCR and 16S rRNA-based sequencing. These strains belonged to five species, Lactobacillus casei, L. delbrueckii, L. fermentum, L. plantarum, and L. pentosus. Antibacterial activities of cell-free supernatants (CFSs) of all the Lactobacillus isolates were estimated through standard agar-well diffusion assay, against commonly occurring food-borne and clinically important human pathogens...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28399941/antimicrobial-potential-of-bacteriocins-in-poultry-and-swine-production
#4
REVIEW
Amel Ben Lagha, Bruno Haas, Marcelo Gottschalk, Daniel Grenier
The routine use of antibiotics in agriculture has contributed to an increase in drug-resistant bacterial pathogens in animals that can potentially be transmitted to humans. In 2000, the World Health Organization identified resistance to antibiotics as one of the most significant global threats to public health and recommended that the use of antibiotics as additives in animal feed be phased out or terminated, particularly those used to treat human infections. Research is currently being carried out to identify alternative antimicrobial compounds for use in animal production...
April 11, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28396417/enterococcus-faecalis-bacteriocin-entv-inhibits-hyphal-morphogenesis-biofilm-formation-and-virulence-of-candida-albicans
#5
Carrie E Graham, Melissa R Cruz, Danielle A Garsin, Michael C Lorenz
Enterococcus faecalis, a Gram-positive bacterium, and Candida albicans, a fungus, occupy overlapping niches as ubiquitous constituents of the gastrointestinal and oral microbiome. Both species also are among the most important and problematic, opportunistic nosocomial pathogens. Surprisingly, these two species antagonize each other's virulence in both nematode infection and in vitro biofilm models. We report here the identification of the E. faecalis bacteriocin, EntV, produced from the entV (ef1097) locus, as both necessary and sufficient for the reduction of C...
April 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28394691/nanostructures-for-delivery-of-natural-antimicrobials-in-food
#6
Nathalie Almeida Lopes, Adriano Brandelli
Natural antimicrobial compounds are a topic of utmost interest in food science due to the increased demand for safe and high-quality foods with minimal processing. The use of nanostructures is an interesting alternative to protect and delivery antimicrobials in food, also providing controlled release of natural compounds such as bacteriocins and antimicrobial proteins, and also for delivery of plant derived antimicrobials. A diversity of nanostructures are capable of trapping natural antimicrobials maintaining the stability of substances that are frequently sensitive to food processing and storage conditions...
April 10, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28386253/current-and-potential-treatments-for-reducing-campylobacter-colonization-in-animal-hosts-and-disease-in-humans
#7
REVIEW
Tylor J Johnson, Janette M Shank, Jeremiah G Johnson
Campylobacter jejuni is the leading cause of bacteria-derived gastroenteritis worldwide. In the developed world, Campylobacter is usually acquired by consuming under-cooked poultry, while in the developing world it is often obtained through drinking contaminated water. Once consumed, the bacteria adhere to the intestinal epithelium or mucus layer, causing toxin-mediated inhibition of fluid reabsorption from the intestine and invasion-induced inflammation and diarrhea. Traditionally, severe or prolonged cases of campylobacteriosis have been treated with antibiotics; however, overuse of these antibiotics has led to the emergence of antibiotic-resistant strains...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28384209/analyses-of-the-probiotic-property-and-stress-resistance-related-genes-of-lactococcus-lactis-subsp-lactis-ncdo-2118-through-comparative-genomics-and-in-vitro-assays
#8
Letícia C Oliveira, Tessália D L Saraiva, Wanderson M Silva, Ulisses P Pereira, Bruno C Campos, Leandro J Benevides, Flávia S Rocha, Henrique C P Figueiredo, Vasco Azevedo, Siomar C Soares
Lactococcus lactis subsp. lactis NCDO 2118 was recently reported to alleviate colitis symptoms via its anti-inflammatory and immunomodulatory activities, which are exerted by exported proteins that are not produced by L. lactis subsp. lactis IL1403. Here, we used in vitro and in silico approaches to characterize the genomic structure, the safety aspects, and the immunomodulatory activity of this strain. Through comparative genomics, we identified genomic islands, phage regions, bile salt and acid stress resistance genes, bacteriocins, adhesion-related and antibiotic resistance genes, and genes encoding proteins that are putatively secreted, expressed in vitro and absent from IL1403...
2017: PloS One
https://www.readbyqxmd.com/read/28377528/listeriolysin-s-is-a-streptolysin-s-like-virulence-factor-that-targets-exclusively-prokaryotic-cells-in-vivo
#9
Juan J Quereda, Marie A Nahori, Jazmín Meza-Torres, Martin Sachse, Patricia Titos-Jiménez, Jaime Gomez-Laguna, Olivier Dussurget, Pascale Cossart, Javier Pizarro-Cerdá
Streptolysin S (SLS)-like virulence factors from clinically relevant Gram-positive pathogens have been proposed to behave as potent cytotoxins, playing key roles in tissue infection. Listeriolysin S (LLS) is an SLS-like hemolysin/bacteriocin present among Listeria monocytogenes strains responsible for human listeriosis outbreaks. As LLS cytotoxic activity has been associated with virulence, we investigated the LLS-specific contribution to host tissue infection. Surprisingly, we first show that LLS causes only weak red blood cell (RBC) hemolysis in vitro and neither confers resistance to phagocytic killing nor favors survival of L...
April 4, 2017: MBio
https://www.readbyqxmd.com/read/28361445/roles-of-probiotic-lactobacilli-inclusion-in-helping-piglets-establish-healthy-intestinal-inter-environment-for-pathogen-defense
#10
REVIEW
Jiajun Yang, Kun Qian, Chonglong Wang, Yijing Wu
The gastrointestinal tract of pigs is densely populated with microorganisms that closely interact with the host and with ingested feed. Gut microbiota benefits the host by providing nutrients from dietary substrates and modulating the development and function of the digestive and immune systems. An optimized gastrointestinal microbiome is crucial for pigs' health, and establishment of the microbiome in piglets is especially important for growth and disease resistance. However, the microbiome in the gastrointestinal tract of piglets is immature and easily influenced by the environment...
March 30, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28352561/synergistic-effect-of-haloduracin-and-chloramphenicol-against-clinically-important-gram-positive-bacteria
#11
Abolghasem Danesh, Åsa Ljungh, Bo Mattiasson, Gashaw Mamo
The emergence of drug-resistant pathogens has triggered the search for more efficient antimicrobial agents and formulations for treatment of infections. In recent years, combination therapy has become one of the effective clinical practices in treating infections. The present study deals with the effect of haloduracin, a lantibiotic bateriocin and chloramphenicol against clinically important bacteria. The combined use of haloduracin and chloramphenicol resulted in remarkable synergy against a spectrum of microorganisms including strains of Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis and different groups of Streptococcus...
March 2017: Biotechnology Reports
https://www.readbyqxmd.com/read/28348880/modification-of-the-streptococcus-mutans-transcriptome-by-lrgab-and-environmental-stressors
#12
Kelly C Rice, Matthew E Turner, O'neshia V Carney, Tongjun Gu, Sang-Joon Ahn
The Streptococcus mutans Cid/Lrg system is central to the physiology of this cariogenic organism, affecting oxidative stress resistance, biofilm formation and competence. Previous transcriptome analyses of lytS (responsible for the regulation of lrgAB expression) and cidB mutants have revealed pleiotropic effects on carbohydrate metabolism and stress resistance genes. In this study, it was found that an lrgAB mutant, previously shown to have diminished aerobic and oxidative stress growth, was also much more growth impaired in the presence of heat and vancomycin stresses, relative to wild-type, lrgA and lrgB mutants...
February 2017: Microbial Genomics
https://www.readbyqxmd.com/read/28344574/health-associated-niche-inhabitants-as-oral-probiotics-the-case-of-streptococcus-dentisani
#13
Arantxa López-López, Anny Camelo-Castillo, María D Ferrer, Áurea Simon-Soro, Alex Mira
Oral diseases, including dental caries and periodontitis, are among the most prevalent diseases worldwide and develop as a consequence of a microbial dysbiosis. Several bacterial strains are being tested as potential oral health-promoting organisms, but usually they are species isolated from niches other than the site where they must exert its probiotic action, typically from fecal samples. We hypothesize that oral inhabitants associated to health conditions will be more effective than traditional, gut-associated probiotic species in key aspects such as colonization of the oral site where disease takes place or the possession of oral health promoting functions, as well as more practical issues like safety and toxicity, and establishing proper doses for administration...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28335414/inhibition-of-listeria-monocytogenes-on-ready-to-eat-meats-using-bacteriocin-mixtures-based-on-mode-of-action
#14
Paul Priyesh Vijayakumar, Peter M Muriana
Bacteriocin-producing (Bac⁺) lactic acid bacteria (LAB) comprising selected strains of Lactobacillus curvatus, Lactococcus lactis, Pediococcus acidilactici, and Enterococcus faecium and thailandicus were examined for inhibition of Listeria monocytogenes during hotdog challenge studies. The Bac⁺ strains, or their cell-free supernatants (CFS), were grouped according to mode-of-action (MOA) as determined from prior studies. Making a mixture of as many MOAs as possible is a practical way to obtain a potent natural antimicrobial mixture to address L...
March 14, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28328596/antibacterial-effect-of-bacteriocin-isolated-from-lactobacillus-plantarum-atcc-8014-on-postoperative-infection-of-mandibular-fracture-in-vivo
#15
Tao Fu, Yan-Ming Liu
OBJECTIVE: The primary objective of this study was to verify the effects of bacteriocin in treatment of postoperative infection of mandibular fracture in vivo. METHODS: Eighty-two mice were inoculated intravenously with staphylococcal suspensions. Bacterial cultures were obtained from implants. Blood samples were collected at 1, 2, 4, 6, and 8 hours after the injection of bacteriocins. RESULTS: Bacteriocins have significant inhibitory effects on Staphylococcus aureus (P < 0...
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28323618/contact-dependent-killing-by-caulobacter-crescentus-via-cell-surface-associated-glycine-zipper-proteins
#16
Leonor García-Bayona, Monica S Guo, Michael T Laub
Most bacteria are in fierce competition with other species for limited nutrients. Some bacteria can kill nearby cells by secreting bacteriocins, a diverse group of proteinaceous antimicrobials. However, bacteriocins are typically freely diffusible, and so of little value to planktonic cells in aqueous environments. Here, we identify an atypical two-protein bacteriocin in the α-proteobacterium Caulobacter crescentus that is retained on the surface of producer cells where it mediates cell contact-dependent killing...
March 21, 2017: ELife
https://www.readbyqxmd.com/read/28323072/impairment-of-the-class-iia-bacteriocin-receptor-function-and-membrane-structural-changes-are-associated-to-enterocin-crl35-high-resistance-in-listeria-monocytogenes
#17
Emilse Masias, Fernando G Dupuy, Paulo Ricardo da Silva Sanches, Juan Vicente Farizano, Eduardo Cilli, Augusto Bellomio, Lucila Saavedra, Carlos Minahk
BACKGROUND: Enterocin CRL35 is a class IIa bacteriocin with anti-Listeria activity. Resistance to these peptides has been associated with either the downregulation of the receptor expression or changes in the membrane and cell walls. The scope of the present work was to characterize enterocin CRL35 resistant Listeria strains with MICs more than 10,000 times higher than the MIC of the WT sensitive strain. METHODS: Listeria monocytogenes INS7 resistant isolates R2 and R3 were characterized by 16S RNA gene sequencing and rep-PCR...
March 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28323017/whole-genome-sequencing-of-bacillus-velezensis-ls69-a-strain-with-a-broad-inhibitory-spectrum-against-pathogenic-bacteria
#18
Guoqiang Liu, Yingying Kong, Yajing Fan, Ce Geng, Donghai Peng, Ming Sun
Bacillus velezensis LS69 was found to exhibit antagonistic activity against a diverse spectrum of pathogenic bacteria. It has one circular chromosome of 3,917,761bp with 3,643 open reading frames. Genome analysis identified ten gene clusters involved in nonribosomal synthesis of polyketides (macrolactin, bacillaene and difficidin), lipopeptides (surfactin, fengycin, bacilysin and iturin A) and bacteriocins (amylolysin and amylocyclicin). In addition, B. velezensis LS69 was found to contain a series of genes involved in enhancing plant growth and triggering plant immunity...
March 18, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28314902/potential-factors-enabling-human-body-colonization-by-animal-streptococcus-dysgalactiae-subsp-equisimilis-strains
#19
Marcin Ciszewski, Eligia M Szewczyk
Streptococcus dysgalactiae subsp. equisimilis (SDSE) is a pyogenic, Lancefield C or G streptococcal pathogen. Until recently, it has been considered as an exclusive animal pathogen. Nowadays, it is responsible for both animal infections in wild animals, pets, and livestock and human infections often clinically similar to the ones caused by group A streptococcus (Streptococcus pyogenes). The risk of zoonotic infection is the most significant in people having regular contact with animals, such as veterinarians, cattlemen, and farmers...
May 2017: Current Microbiology
https://www.readbyqxmd.com/read/28299945/in-vitro-and-in-vivo-cholesterol-lowering-ability-of-lactobacillus-pentosus-kf923750
#20
F Bendali, K Kerdouche, S Hamma-Faradji, D Drider
Lactobacillus pentosus KF923750 was characterised for probiotic related properties and then characterised for cholesterol uptake in vitro as well as in vivo using rabbits fed a high-cholesterol diet. The survival percentage of L. pentosus KF923750 was 100% at pH 3, 52.18% at pH 2 and 36.21% at pH 2 plus pepsin. Similarly, this strain appeared resistant to bile (0.1% [98.42%], 0.3% [88.52%], 0.5% [75.60%] and 1% [71.15%]), after 4 h exposure. Moreover, L. pentosus KF923750 controlled growth of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 through the production of a bacteriocin-like inhibitory substance and anti-adhesive capabilities...
March 16, 2017: Beneficial Microbes
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