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https://www.readbyqxmd.com/read/29221986/streptococcus-pneumoniae-two-component-regulatory-systems-the-interplay-of-the-pneumococcus-with-its-environment
#1
REVIEW
Alejandro Gómez-Mejia, Gustavo Gámez, Sven Hammerschmidt
Streptococcus pneumoniae is a human pathobiont possessing a diverse array of multifunctional proteins essential for bacterial fitness and virulence. Gene expression is tightly controlled by regulatory components and among the pneumococcal sensorial tools, two‑component regulatory systems (TCS) are the most widespread and conserved. This review aims to provide a comprehensive analysis of original studies on pneumococcal TCS on a functional level. Despite a rather chaotic nomenclature, the current available information on pneumococcal regulation by these systems can be conveniently addressed, according to the regulation of pathophysiological cell processes and the responses to detectable environmental signals...
November 26, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29216827/comparative-genomic-analysis-of-brevibacterium-strains-insights-into-key-genetic-determinants-involved-in-adaptation-to-the-cheese-habitat
#2
Nguyen-Phuong Pham, Séverine Layec, Eric Dugat-Bony, Marie Vidal, Françoise Irlinger, Christophe Monnet
BACKGROUND: Brevibacterium strains are widely used for the manufacturing of surface-ripened cheeses, contributing to the breakdown of lipids and proteins and producing volatile sulfur compounds and red-orange pigments. The objective of the present study was to perform comparative genomic analyses in order to better understand the mechanisms involved in their ability to grow on the cheese surface and the differences between the strains. RESULTS: The genomes of 23 Brevibacterium strains, including twelve strains isolated from cheeses, were compared for their gene repertoire involved in salt tolerance, iron acquisition, bacteriocin production and the ability to use the energy compounds present in cheeses...
December 7, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29204423/dual-coating-of-liposomes-as-encapsulating-matrix-of-antimicrobial-peptides-development-and-characterization
#3
Ahmed I Gomaa, Cynthia Martinent, Riadh Hammami, Ismail Fliss, Muriel Subirade
Antimicrobial peptides have been proposed as a potential biopreservatives in pharmaceutical research and agribusiness. However, many limitations hinder their utilization, such as their vulnerability to proteolytic digestion and their potential interaction with other food ingredients in complex food systems. One approach to overcome such problems is developing formulations entrapping and thereby protecting the antimicrobial peptides. Liposome encapsulation is a strategy that could be implemented to combine protection of the antimicrobial activity of the peptides from proteolytic enzymes and the controlled release of the encapsulated active ingredients...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29201559/genomic-characterization-of-a-new-endophytic-streptomyces-kebangsaanensis-identifies-biosynthetic-pathway-gene-clusters-for-novel-phenazine-antibiotic-production
#4
Juwairiah Remali, Nurul 'Izzah Mohd Sarmin, Chyan Leong Ng, John J L Tiong, Wan M Aizat, Loke Kok Keong, Noraziah Mohamad Zin
Background: Streptomyces are well known for their capability to produce many bioactive secondary metabolites with medical and industrial importance. Here we report a novel bioactive phenazine compound, 6-((2-hydroxy-4-methoxyphenoxy) carbonyl) phenazine-1-carboxylic acid (HCPCA) extracted from Streptomyces kebangsaanensis, an endophyte isolated from the ethnomedicinal Portulaca oleracea. Methods: The HCPCA chemical structure was determined using nuclear magnetic resonance spectroscopy...
2017: PeerJ
https://www.readbyqxmd.com/read/29192090/complete-genome-sequence-of-lactobacillus-plantarum-10ch-a-potential-probiotic-lactic-acid-bacterium-with-potent-antimicrobial-activity
#5
Nancy M El Halfawy, Moustafa Y El-Naggar, Simon C Andrews
Lactobacillus plantarum 10CH is a bacteriocin-producing potential probiotic lactic acid bacterium (LAB) strain isolated from cheese. Its complete nucleotide sequence shows a single circular chromosome of 3.3 Mb, with a G+C content of 44.51%, a 25-gene plantaricin bacteriocin gene cluster, and the absence of recognized virulence factors.
November 30, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29180375/formation-and-characterization-of-early-bacterial-biofilms-on-different-wood-typologies-applied-in-dairy-production
#6
Margherita Cruciata, Raimondo Gaglio, Maria Luisa Scatassa, Giovanna Sala, Cinzia Cardamone, Marisa Palmeri, Giancarlo Moschetti, Tommaso La Mantia, Luca Settanni
Main hypothesis: Sicilian forestry resources are suitable for the production of equipment to be used in cheese making and indigenous milk lactic acid bacteria (LAB) are able to develop stable biofilms providing starter and non starter cultures necessary for curd fermentation and cheese ripening, respectively. Hence, the present work was carried out to evaluate LAB biofilm formation on different woods derived from trees species grown in Sicily with deproteinized whey. Microbiological and scanning electron microscopy analyses showed minimal differences in microbial levels and composition for the neoformed biofilms...
November 27, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29179097/preservation-of-large-yellow-croaker-pseudosciaena-crocea-by-coagulin-l1208-a-novel-bacteriocin-produced-by-bacillus-coagulans-l1208
#7
Linglin Fu, Chong Wang, Xinming Ruan, Gang Li, Yu Zhao, Yanbo Wang
Large yellow croaker (Pseudosciaena crocea) is a cultivated fish of great economic importance and abundant nutritional value. However, due to its high protein and water contents, it is susceptible to decomposition, leading to considerable economic loss and adverse effects on consumer health. Here, we assessed the function of the bacterial strain Bacillus coagulans L1208 (Bcoa) in preserving large yellow croaker during storage at 4°C and found that Bcoa elongates the shelf-life significantly. Further investigations showed that Bcoa prolongs the storage time mainly by suppressing the growth of spoilage bacteria...
November 21, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29177756/leucocin-c-607-a-novel-bacteriocin-from-the-multiple-bacteriocin-producing-leuconostoc-pseudomesenteroides-607-isolated-from-persimmon
#8
Yi-Sheng Chen, Hui-Chung Wu, Cheng-Yu Kuo, Yu-Wei Chen, Sin Ho, Fujitoshi Yanagida
Leuconostoc pseudomesenteroides 607, isolated from persimmon fruit, was found to have high inhibitory activity against Listeria monocytogenes and several other Gram-positive bacteria. Inhibitory substances were purified from culture supernatant by ion-exchange chromatography, Sep-Pak C18 cartridge, and reverse-phase high-performance liquid chromatography (RP-HPLC). Two antibacterial peptides were observed during the purification procedures. One of these peptides had a molecular size of 4623.05 Da and a partial N-terminal amino acid sequence of NH2-KNYGNGVHxTKKGxS, in which the YGNGV motif is specific for class IIa bacteriocins...
November 25, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29167919/propionibacterium-spp-source-of-propionic-acid-vitamin-b12-and-other-metabolites-important-for-the-industry
#9
REVIEW
Kamil Piwowarek, Edyta Lipińska, Elżbieta Hać-Szymańczuk, Marek Kieliszek, Iwona Ścibisz
Bacteria from the Propionibacterium genus consists of two principal groups: cutaneous and classical. Cutaneous Propionibacterium are considered primary pathogens to humans, whereas classical Propionibacterium are widely used in the food and pharmaceutical industries. Bacteria from the Propionibacterium genus are capable of synthesizing numerous valuable compounds with a wide industrial usage. Biomass of the bacteria from the Propionibacterium genus constitutes sources of vitamins from the B group, including B12, trehalose, and numerous bacteriocins...
November 22, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29164486/adaptation-and-probiotic-potential-of-lactobacilli-isolated-from-the-oral-cavity-and-intestines-of-healthy-people
#10
Yulia Chervinets, Vyacheslav Chervinets, Boris Shenderov, Ekaterina Belyaeva, Andrey Troshin, Sergey Lebedev, Valery Danilenko
The present study shows that, from 300 Lactobacillus strains isolated from the oral cavity and large intestine of 600 healthy people, only 9 had high antagonistic activity against pathogens and opportunistic pathogens. All antagonistic strains of lactobacilli have been identified by 16S rRNA sequencing and assigned to four species: Lactobacillus fermentum, Lactobacillus rhamnosus, Lactobacillus plantarum, and Lactobacillus casei. In addition, these lactobacilli appeared to be nonpathogenic and had some probiotic potential: the strains produced lactic acid and bacteriocins, showed high sensitivity to broad-spectrum antibiotics, and were capable of forming biofilms in vitro...
November 21, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29162929/genomic-assessment-in-lactobacillus-plantarum-links-the-butyrogenic-pathway-with-glutamine-metabolism
#11
Cristian Botta, Alberto Acquadro, Anna Greppi, Lorenzo Barchi, Marta Bertolino, Luca Cocolin, Kalliopi Rantsiou
The butyrogenic capability of Lactobacillus (L.) plantarum is highly dependent on the substrate type and so far not assigned to any specific metabolic pathway. Accordingly, we compared three genomes of L. plantarum that showed a strain-specific capability to produce butyric acid in human cells growth media. Based on the genomic analysis, butyric acid production was attributed to the complementary activities of a medium-chain thioesterase and the fatty acid synthase of type two (FASII). However, the genomic islands of discrepancy observed between butyrogenic L...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162546/evaluation-of-probiotic-bacillus-aerius-b81e-isolated-from-healthy-hybrid-catfish-on-growth-disease-resistance-and-innate-immunity-of-pla-mong-pangasius-bocourti
#12
Ratchanu Meidong, Kulwadee Khotchanalekha, Sompong Doolgindachbaporn, Takahiro Nagasawa, Miki Nakao, Kenji Sakai, Saowanit Tongpim
Infectious diseases have been found to be a major cause of mortality in fish hatcheries. Probiotics have been introduced to replace antibiotics commonly used for treatment of bacterial infection in aquaculture. This study was conducted to isolate, screen, and evaluate the probiotic Bacillus spp. for potential use as a feed supplement to enhance fish growth, disease resistance and innate immunity of Pla-mong Pangasius bocourti. Bacillus aerius strain B81e was selectively isolated from the intestine of healthy catfish and chosen based on its probiotic properties both in vitro and in vivo...
November 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29150081/turning-over-a-new-leaf-bacteriocins-going-green
#13
Maarten G K Ghequire, René De Mot
Bacteriocins are potent antibacterial proteins that selectively kill phylogenetic relatives of the producer. Their polymorphic nature, most prominent in γ-Proteobacteria, offers potential for the design of customized bacteriocin cocktails targeting Gram-negative pathogens. As an alternative to recombinant production in bacteria, they are eligible for large-scale production in plants.
November 14, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/29141957/adherent-invasive-escherichia-coli-in-inflammatory-bowel-disease
#14
REVIEW
Carolina Palmela, Caroline Chevarin, Zhilu Xu, Joana Torres, Gwladys Sevrin, Robert Hirten, Nicolas Barnich, Siew C Ng, Jean-Frederic Colombel
Intestinal microbiome dysbiosis has been consistently described in patients with IBD. In the last decades, Escherichia coli, and the adherent-invasive E coli (AIEC) pathotype in particular, has been implicated in the pathogenesis of IBD. Since the discovery of AIEC, two decades ago, progress has been made in unravelling these bacteria characteristics and its interaction with the gut immune system. The mechanisms of adhesion of AIEC to intestinal epithelial cells (via FimH and cell adhesion molecule 6) and its ability to escape autophagy when inside macrophages are reviewed here...
November 15, 2017: Gut
https://www.readbyqxmd.com/read/29136796/a-multi-purpose-tool-for-food-inspection-simultaneous-determination-of-various-classes-of-preservatives-and-biogenic-amines-in-meat-and-fish-products-by-lc-ms
#15
Luciano Molognoni, Heitor Daguer, Leandro Antunes de Sá Ploêncio, Juliano De Dea Lindner
This paper describes an innovative fast and multipurpose method for the chemical inspection of meat and fish products by liquid chromatography-tandem mass spectrometry. Solid-liquid extraction and low temperature partitioning were applied to 17 analytes, which included large bacteriocins (3.5kDa) and small molecules (organic acids, heterocyclic compounds, polyene macrolides, alkyl esters of the p-hydroxybenzoic acid, aromatic, and aliphatic biogenic amines and polyamines). Chromatographic separation was achieved in 10min, using stationary phase of di-isopropyl-3-aminopropyl silane bound to hydroxylated silica...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29122869/complete-genome-sequence-of-streptococcus-thermophilus-strain-b59671-which-naturally-produces-the-broad-spectrum-bacteriocin-thermophilin-110
#16
John A Renye, David S Needleman, George A Somkuti, Dennis H Steinberg
Streptococcus thermophilus strain B59671 is a Gram-positive lactic acid bacterium that naturally produces a broad-spectrum bacteriocin, thermophilin 110, and is capable of producing gamma-aminobutyric acid (GABA). The complete genome sequence for this strain contains 1,821,173 nucleotides, 1,936 predicted genes, and an average G+C content of 39.1%.
November 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29107139/spatial-attributes-of-the-four-helix-bundle-group-of-bacteriocins-the-high-resolution-structure-of-bacsp222-in-solution
#17
Michał Nowakowski, Łukasz Jaremko, Benedykt Wladyka, Grzegorz Dubin, Andrzej Ejchart, Paweł Mak
BacSp222 is a multifunctional bacteriocin produced by Staphylococcus pseudintermedius strain 222, an opportunistic pathogen of domestic animals. At micromolar concentrations, BacSp222 kills Gram-positive bacteria and is cytotoxic toward mammalian cells, while at nanomolar doses, it acts as an immunomodulatory factor, enhancing nitric oxide release in macrophage-like cell lines. The bacteriocin is a cationic, N-terminally formylated, 50-amino-acid-long linear peptide that is rich in tryptophan residues. In this study, the solution structure of BacSp222 was determined and compared to the currently known structures of similar bacteriocins...
October 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29097478/draft-genome-sequence-of-staphylococcus-aureus-4185-a-strain-that-produces-aureocyclicin-4185
#18
Márcia Silva Francisco, Felipe Miceli Farias, Ilana Nascimento Sousa Santos, Selda Loase Salustiano Marques-Bastos, Rodolpho Mattos Albano, Maria do Carmo Freire Bastos
The draft genome sequence of the aureocyclicin 4185-producing strain Staphylococcus aureus 4185 is presented. The assembly contains 2,789,721 bp and a G+C content of 32.8%. Genome analysis allowed us to determine the complete sequence of the bacteriocinogenic plasmid pRJ101 and to find another bacteriocin gene cluster encoded on the bacterial chromosome.
November 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29091578/dual-label-flow-cytometry-based-host-cell-adhesion-assay-to-ascertain-the-prospect-of-probiotic-lactobacillus-plantarum-in-niche-specific-antibacterial-therapy
#19
Sandipan Mukherjee, Aiyagari Ramesh
Host cell adhesion assays that provide quantitative insight on the potential of lactic acid bacteria (LAB) to inhibit adhesion of intestinal pathogens can be leveraged for the development of niche-specific anti-adhesion therapy. Herein, we report a dual-colour flow cytometry (FCM) analysis to assess the ability of probiotic Lactobacillus plantarum strains to impede adhesion of Enterococcus faecalis, Listeria monocytogenes and Staphylococcus aureus onto HT-29 cells. FCM in conjunction with a hierarchical cluster analysis could discern the anti-adhesion potential of L...
November 1, 2017: Microbiology
https://www.readbyqxmd.com/read/29078392/exploitation-of-an-iron-transporter-for-bacterial-protein-antibiotic-import
#20
Paul White, Amar Joshi, Patrice Rassam, Nicholas G Housden, Renata Kaminska, Jonathan D Goult, Christina Redfield, Laura C McCaughey, Daniel Walker, Shabaz Mohammed, Colin Kleanthous
Unlike their descendants, mitochondria and plastids, bacteria do not have dedicated protein import systems. However, paradoxically, import of protein bacteriocins, the mechanisms of which are poorly understood, underpins competition among pathogenic and commensal bacteria alike. Here, using X-ray crystallography, isothermal titration calorimetry, confocal fluorescence microscopy, and in vivo photoactivatable cross-linking of stalled translocation intermediates, we demonstrate how the iron transporter FpvAI in the opportunistic pathogen Pseudomonas aeruginosa is hijacked to translocate the bacteriocin pyocin S2 (pyoS2) across the outer membrane (OM)...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
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