keyword
https://read.qxmd.com/read/38530413/risk-factors-associated-with-in-hospital-complications-for-pediatric-sickle-cell-disease-associated-moyamoya-syndrome-a-nationwide-cross-sectional-study
#1
JOURNAL ARTICLE
Robert C Osorio, Kunal P Raygor, Lorenzo Rinaldo, Christine K Fox, Neha Bhasin, Adib A Abla, Nalin Gupta
PURPOSE: Sickle-cell disease-associated moyamoya syndrome (SCD-MMS) carries a high risk for recurrent strokes and cerebrovascular morbidity in children. However, few data are available about complications that occur in children hospitalized with SCD-MMS. The purpose of this analysis was to determine the risk factors for in-hospital complications in pediatric SCD-MMS admissions, and thus aid physicians in optimizing future treatment plans. METHODS: A national database of pediatric hospital admissions was examined across the years 2003-2019...
March 26, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38522868/how-i-do-it-aortic-annular-enlargement-are-the-nicks-and-manouguian-obsolete
#2
REVIEW
Kenneth R Hassler, Katelyn Monaghan, China Green, Bo Yang
The Y-incision aortic annular enlargement (AAE), first performed in August 2020, offers a safe and more effective alternative for management of a small aortic annulus/root without need for violation of the left ventricular outflow tract, mitral valve geometry, or left/right atria in both first-time aortic valve replacement (AVR) and reoperative AVR. In the first consecutive 119 patients with Y-incision AAE, the median age was 65 (59, 71), 67% female, 28% had previous cardiac surgery, and 2 cases had endocarditis...
2024: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://read.qxmd.com/read/38507752/intrathecal-gene-therapy-for-giant-axonal-neuropathy
#3
JOURNAL ARTICLE
Diana X Bharucha-Goebel, Joshua J Todd, Dimah Saade, Gina Norato, Minal Jain, Tanya Lehky, Rachel M Bailey, Jessica A Chichester, Roberto Calcedo, Diane Armao, A Reghan Foley, Payam Mohassel, Eshetu Tesfaye, Bradley P Carlin, Beth Seremula, Melissa Waite, Wadih M Zein, Laryssa A Huryn, Thomas O Crawford, Charlotte J Sumner, Ahmet Hoke, John D Heiss, Lawrence Charnas, Jody E Hooper, Thomas W Bouldin, Elizabeth M Kang, Denis Rybin, Steven J Gray, Carsten G Bönnemann
BACKGROUND: Giant axonal neuropathy is a rare, autosomal recessive, pediatric, polysymptomatic, neurodegenerative disorder caused by biallelic loss-of-function variants in GAN , the gene encoding gigaxonin. METHODS: We conducted an intrathecal dose-escalation study of scAAV9/JeT-GAN (a self-complementary adeno-associated virus-based gene therapy containing the GAN transgene) in children with giant axonal neuropathy. Safety was the primary end point. The key secondary clinical end point was at least a 95% posterior probability of slowing the rate of change (i...
March 21, 2024: New England Journal of Medicine
https://read.qxmd.com/read/38497171/stroke-without-cerebral-arteriopathy-in-sickle-cell-disease-children-causes-and-treatment
#4
JOURNAL ARTICLE
Sarah Liane Linguet, Suzanne Verlhac, Florence Missud, Laurent Holvoet-Vermaut, Valentine Brousse, Ghislaine Ithier, Alexandra Ntorkou, Emmanuelle Lesprit, Malika Benkerrou, Manoëlle Kossorotoff, Berengere Koehl
Cerebral arteriopathy (CA) in children with sickle cell disease (SCD) is classically described as chronic stenosis of arteries in the anterior brain circulation, leading to ischemic stroke. Some studies have however reported strokes in children with SCD but without CA. In order to better understand the etiology and risk factors of these strokes, we retrospectively analyzed ischemic strokes occurring in a large cohort of children over a 13 year-period. Between 2007 and 2020, 25/1500 children with SCD had an ischemic stroke in our center...
March 14, 2024: Haematologica
https://read.qxmd.com/read/38496778/are-tactile-function-and-body-awareness-of-the-foot-related-to-motor-outcomes-in-children-with-upper-motor-neuron-lesions
#5
JOURNAL ARTICLE
Petra Marsico, Lea Meier, Marietta L van der Linden, Thomas H Mercer, Hubertus J A van Hedel
INTRODUCTION: Somatosensory function can be reduced in children with Upper Motor Neuron (UMN) lesions. Therefore, we investigated relationships between somatosensory functions of the foot and motor outcomes in children with UMN lesions. METHOD: In this cross-sectional study, we assessed the Tactile Threshold (TT) with monofilaments and body awareness with Tactile Localisation Tasks for spatial-related action (TLTaction ) and structural-related perception (TLTperception ) body representation at the foot sole...
2024: Front Rehabil Sci
https://read.qxmd.com/read/38496124/when-hearts-and-minds-collide-a-case-report-of-left-ventricle-noncompaction-syndrome-as-a-precursor-to-acute-ischemic-stroke-in-a-15-year-old-along-with-a-literature-review
#6
Yousif Alkhafaji, Omar Farooq Al-Nahhas, Khaled Alaboud Alkheder, Jamal A Alkoteesh
Pediatric stroke, though uncommon, is often underdiagnosed due to subtle symptoms and delayed recognition. Cardiac diseases, accounting for up to 33% of pediatric ischemic strokes, play a significant role. This case report explores the rare occurrence of ischemic stroke in a 15-year-old boy with left ventricular non-compaction syndrome (LVNC). It underscores the complexity of managing pediatric ischemic stroke, particularly in the context of LVNC, emphasizing the challenges in timely diagnosis and management...
February 2024: Curēus
https://read.qxmd.com/read/38495962/cerebral-infarction-due-to-post-traumatic-cerebral-vasospasm-in-a-12-year-old-female
#7
Daisuke Tanikawa, Yushiro Take, Nobuaki Naito, Akio Teranishi, Hiroki Kurita
Cerebral infarction due to post-traumatic cerebral vasospasm is rare. Although some modalities are recommended to detect post-traumatic cerebral vasospasm, its diagnosis remains controversial and challenging. Therefore, in this report, we will use a case report to highlight challenges and to delineate the characteristics of post-traumatic cerebral vasospasm in pediatric patients, including the diagnostic and treatment options. A 12-year-old female was admitted to our hospital following a motor vehicle collision...
March 2024: Curēus
https://read.qxmd.com/read/38494306/epidemiology-of-thromboembolic-events-in-children-and-adolescents-with-antiphospholipid-syndrome-a-systematic-review-with-meta-analysis
#8
REVIEW
Mickael Essouma, Jan Rene Nkeck, Jean Jacques Noubiap
BACKGROUND AND AIM: This was a systematic review and meta-analysis of the prevalence of thromboembolic events in children and adolescents with antiphospholipid syndrome (APS). METHODS: We searched PubMed, EMBASE and Web of Science to select relevant articles published between 1 January 2000 and 27 February 2022. We used the random-effects meta-analysis to estimate pooled point prevalence rates of thromboembolic events in studies with a minimum sample size of 30...
March 2024: Reumatología clinica
https://read.qxmd.com/read/38492257/hereditary-hemorrhagic-telangiectasia-diagnosis-a-case-report
#9
JOURNAL ARTICLE
Lynne Sekarski, Andrew J White, Katheryne Tifuh Amba
This case report presents a 13-year-old patient with a lung nodule identified on a chest radiograph in the emergency department during an evaluation of knee and side pain after a fall. The patient had nosebleeds, family history of hereditary hemorrhagic telangiectasia (HHT) and after chest computed tomography with angiography, the nodule was defined as a single pulmonary arteriovenous malformation (PAVM). Neither parent nor patient had been evaluated for HHT, an autosomal dominant disease, despite the family history...
March 15, 2024: Journal of Pediatric Nursing
https://read.qxmd.com/read/38488858/exploring-the-types-of-social-support-exchanged-by-survivors-of-pediatric-stroke-and-their-families-in-an-online-peer-support-community-qualitative-thematic-analysis
#10
JOURNAL ARTICLE
William J A Wright, Charlotte Howdle, Neil S Coulson, Anna De Simoni
BACKGROUND: Pediatric stroke is relatively rare and underresearched, and there is little awareness of its occurrence in wider society. There is a paucity of literature on the effectiveness of interventions to improve rehabilitation and the services available to survivors. Access to online health communities through the internet may be a means of support for patients with pediatric stroke and their families during recovery; however, little research has been done in this area. OBJECTIVE: This study aims to identify the types of social support provided by an online peer support group to survivors of pediatric stroke and their families...
March 15, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38488379/health-inequity-and-time-from-pediatric-stroke-onset-to-arrival
#11
JOURNAL ARTICLE
Akshat M Pai, Teresa To, Gabrielle A deVeber, Daniel Nichol, Andrea Kassner, Birgit Ertl-Wagner, Mubeen F Rafay, Nomazulu Dlamini
BACKGROUND: Time from stroke onset to hospital arrival determines treatment and impacts outcome. Structural, socioeconomic, and environmental factors are associated with health inequity and onset-to-arrival in adult stroke. We aimed to assess the association between health inequity and onset-to-arrival in a pediatric comprehensive stroke center. METHODS: A retrospective observational study was conducted on a consecutive cohort of children (>28 days-18 years) diagnosed with acute arterial ischemic stroke (AIS) between 2004 and 2019...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38465648/cardiovascular-management-of-patients-undergoing-hematopoietic-stem-cell-transplantation-from-pretransplantation-to-survivorship-a-scientific-statement-from-the-american-heart-association
#12
REVIEW
Salim S Hayek, Vlad G Zaha, Carmel Bogle, Anita Deswal, Amelia Langston, Seth Rotz, Alexi Vasbinder, Eric Yang, Tochukwu Okwuosa
Hematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with cardiovascular diseases. Cardiovascular evaluations are crucial in pretransplantation assessments, but guidelines are lacking. This American Heart Association scientific statement summarizes the data on transplantation-related complications and provides guidance for the cardiovascular management throughout transplantation. Hematopoietic stem cell transplantation consists of 4 phases: pretransplantation workup, conditioning therapy and infusion, immediate posttransplantation period, and long-term survivorship...
March 11, 2024: Circulation
https://read.qxmd.com/read/38452996/achieving-consensus-severity-graded-definitions-of-fontan-associated-complications-to-characterize-fontan-circulatory-failure
#13
JOURNAL ARTICLE
Kurt R Schumacher, Ari Cedars, Kiona Allen, David Goldberg, Adrianna Batazzi, Garrett Reichle, Frank DiPaola, David Selewski, Melissa Cousino, David N Rosenthal
BACKGROUND: Fontan physiology leads to chronic changes in other organ systems that may affect long-term survival and the success of heart transplantation. Inadequate assessment and treatment of the extra-cardiac effects of Fontan may contribute to poor outcomes. Severity graded/ordinal consensus definitions of Fontan complications are lacking which limits understanding of how Fontan-specific morbidity affects patient outcomes. METHODS AND RESULTS: A panel of Fontan patient and physiology experts, including pediatric, adult congenital, heart failure, and critical care cardiology, and pediatric nephrology, hepatology and psychology, convened to develop definitions of Fontan complications...
March 5, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38445467/inflammatory-type-focal-cerebral-arteriopathy-of-the-posterior-circulation-in-children-a-comparative-cohort-study
#14
JOURNAL ARTICLE
Nedelina Slavova, Robin Muenger, Iciar Sanchez-Albisua, Maria Regényi, Gabriela Oesch, Joël Fluss, Annette Hackenberg, Sébastien Lebon, Oliver Maier, Alexandre N Datta, Sandra Bigi, Sebastian Grunt, Maja Steinlin
BACKGROUND: Inflammatory type focal cerebral arteriopathy (FCA-i) in the anterior circulation (AC) is well characterized, and the focal cerebral arteriopathy severity score (FCASS) reflects the severity of the disease. We identified cases of FCA-i in the posterior circulation (PC) and adapted the FCASS to describe these cases. METHODS: In this comparative cohort study, patients from the Swiss NeuroPaediatric Stroke Registry with ischemic stroke due to FCA-i between January 2000 and December 2018 were analyzed...
March 6, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38444343/national-quality-indicators-in-pediatric-sickle-cell-anemia
#15
JOURNAL ARTICLE
Ashaunta T Anderson, Wendy J Mack, Sophia S Horiuchi, Susan Paulukonis, Mei Zhou, Angela B Snyder, Jason N Doctor, Michele Kipke, Thomas Coates, Gary Freed
OBJECTIVE: To assess nationally endorsed claims-based quality measures in pediatric sickle cell anemia (SCA). METHODS: Using data from the Sickle Cell Data Collection programs in California and Georgia from 2010 to 2019, we evaluated 2 quality measures in individuals with hemoglobin S/S or S/β-zero thalassemia: (1) the proportion of patients aged 3 months to 5 years who were dispensed antibiotic prophylaxis for at least 300 days within each measurement year and (2) the proportion of patients aged 2 to 15 years who received at least 1 transcranial Doppler ultrasound (TCD) within each measurement year...
March 6, 2024: Pediatrics
https://read.qxmd.com/read/38433517/management-of-pediatric-intracranial-arteriovenous-malformations
#16
JOURNAL ARTICLE
Alfred Pokmeng See, Edward R Smith
Pediatric intracranial arteriovenous malformations (AVMs) are challenging lesions managed by pediatric neurosurgeons. The high risk of hemorrhage and neurologic injury is compounded by the unique anatomy of each malformation that requires individualizing treatment options. This article reviews the current status of pediatric AVM epidemiology, pathophysiology and clinical care, with a specific focus on the rationale and methodology of surgical resection.
March 4, 2024: Journal of Korean Neurosurgical Society
https://read.qxmd.com/read/38420558/brain-injury-and-neurodevelopmental-outcomes-in-children-undergoing-surgery-for-congenital-heart-disease
#17
JOURNAL ARTICLE
Justus G Reitz, David Zurakowski, Viktoria A Kuhn, Johnathan Murnick, Mary T Donofrio, Yves d'Udekem, Daniel Licht, Agnieszka Kosiorek, Catherine Limperopoulos, Roland Axt-Fliedner, Can Yerebakan, Jessica L Carpenter
OBJECTIVES: Brain injury is commonly seen on magnetic resonance imaging in infants with complex congenital heart disease. The impact of perioperative brain injury on neurodevelopmental outcomes is not well understood. We evaluate the association of brain injury and other markers on neurodevelopmental outcomes in patients undergoing surgery for congenital heart surgery during infancy. METHODS: Term newborns with infant cardiac surgery performed between 2008 and 2019 at a single tertiary center, and both preoperative and postoperative brain magnetic resonance imaging were included...
February 2024: JTCVS open
https://read.qxmd.com/read/38410021/vascular-health-after-assisted-reproduction-a-stroke-of-bad-luck
#18
JOURNAL ARTICLE
Natalie Dayan, Jacob A Udell
No abstract text is available yet for this article.
February 26, 2024: Paediatric and Perinatal Epidemiology
https://read.qxmd.com/read/38408700/pediatric-donut-shaped-basilar-artery-aneurysm
#19
JOURNAL ARTICLE
Zeferino Demartini, Renato Fedatto Beraldo, Bernardo C A Teixeira
Intracranial aneurysms are uncommon in the pediatric population. We present a case of a 11-year-old boy presenting with subarachnoid hemorrhage caused by a "donut-shaped" basilar tip aneurysm. It occurs when the flow geometry produces a circumferential laminar flow into the aneurysmal sac, resulting in a central thrombosis. Optimal management of this type of aneurysm is not already clear, and further studies are needed to clarify the best treatment approach, especially in the pediatric population.
February 24, 2024: World Neurosurgery
https://read.qxmd.com/read/38408160/recurrent-nontraumatic-subgaleal-hematomas-in-a-pediatric-patient-with-sickle-cell-disease
#20
JOURNAL ARTICLE
Irtiza N Sheikh, Olayinka Okeleji, Rabya Afzal, Eliana Bonfante, Monica Kodakandla, Neethu M Menon
Spontaneous subgaleal hematoma in pediatric patients with sickle cell disease (SCD) is a rare occurrence that can present with symptoms mimicking ischemic stroke, a known complication of SCD. However, unlike ischemic stroke, subgaleal hematoma is nonlethal and can be managed conservatively without major sequelae. Here, we present the case of an adolescent with SCD who presented with 2 episodes of subgaleal and epidural hematomas, 2 years apart. The latter episode occurred while on crizanlizumab, an anti-P-selectin antibody, approved for use in SCD in 2019 to reduce the number of acute pain crises...
February 19, 2024: Journal of Pediatric Hematology/oncology
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