Fabio Caputo, Francesco Penitenti, Barbara Bergonzoni, Lisa Lungaro, Anna Costanzini, Giacomo Caio, Roberto DE Giorgio, Maria R Ambrosio, Giorgio Zoli, Gianni Testino
Alcoholic liver disease (ALD) is currently, worldwide, the second most common cause of human fatalities every year. Alcohol use disorders (AUDs) lead to 80% of hepatotoxic deaths, and about 40% of cases of cirrhosis are alcohol-related. An acceptable daily intake (ADI) of ethanol is hard to establish and studies somewhat controversially recommend a variety of dosages of ADI, whilst others regard any intake as dangerous. Steatohepatitis should be viewed as "the rate limiting step": generally, it can be overcome by abstinence, although in some patients, abstinence has little effect, with the risk of fibrosis, leading in some cases to hepatocellular carcinoma (HCC)...
May 9, 2024: Minerva Medica